TO FEEL & STAY MORE TO FEEL & STAY MORE YOUTHFULYOUTHFUL

Our Skin

Understanding Our Skin Structure -

Hypodermis• The skin is made up of 3 layers.

• The bottom or deepest layer of the skin is the hypodermis. It is made up of fatty tissue that cushions & supports the two layers of skin above it.

• The middle layer of skin

• It contains collagen & elastin which give the

skin its form, shape & elasticity.

Understanding Our Skin Structure - Dermis

• The collagen & elastin in young, healthy skin are constantly renewed.

• Older skin tends to sag & wrinkle because the collagen & elastin are damaged & not renewed as often.

• The dermis is also where the blood capillaries, hair follicles, sweat & oil glands are found.

• As we age, oil glands become less active, causing skin to become drier & more prone to the formation of fine lines.

Understanding Our Skin Structure - Dermis

• The top layer of the skin

• This is where the critical function of cell renewal takes place.

Understanding Our Skin Structure - Epidermis

Skin Renew Process• New skin cells are born at the base & slowly move upward,

losing moisture & flattening out as they rise until they form a paper thin barrier at the top of the epidermis.

• The cells in younger skin are replaced about every 15-30 days. But as we age, this process takes twice as

long.

Skin Renew ProcessThis indispensable new barrier

protects skin from

moisture loss and

environmental dam

age.

RESULTING IN

Major Factors affecting our skin to age

(1) Sun

- 80% of visible skin ageing is due to UV light exposure.

- the UV light damages moisture barrier in the epidermis & elastin and

collagen in the dermis.

- resulting in skin loses its elasticity, forming of fine lines and wrinkles

formation of dark spots on the skin as skin produces excess melanin.

Damage to the moisture barrier

Skin produces excess melanin

Elastin & Collagen damaged

(2) Hormonal Ageing

- The first five years following menopause, the skin loses up to 30% of its

supportive collagen fibres.

- As a result, the skin becomes thinner, skin becomes less capable of

storing moisture, becomes drier and wrinkles deepen.

- Now, the skin is more prone to damages caused by free radicals as the

cell renewal process slows down.

(3) Pollution

- Airborne pollutants such as dirt and

dust, present in most modern environments,

especially in densely populated or

industrialized areas – are harmful to the skin.

Major Factors affecting our skin to age

(4) Air-Conditioning

- Dry, dehydrate the skin, leaving epidermis dry.

- Dehydration damages the skin’s barrier function and increases evaporation of dermal

moisture.

(5) Sleep

- Sleep deprivation leads to dull complexion & dark, puffy under-eye circles.

- Skin tend to premature lines and wrinkles.

Major Factors affecting our skin to age

(6) Stress

- Anxiety and anger will increase sebum production in the skin.

(7) Alcohol

- Drinking in excess leads to skin dehydration and robs the body’s nutrients

(Vitamin A,B,C and the minerals magnesium & zinc.)

(8) Smoking

- Smoking reduces the supply of blood to the skin’s surface, restricting the flow of

essential nutrients.

- Skin dull and greyish in colour

- Smokers tend to have thinner skin & premature appearance of

lines and wrinkles.

Major Factors affecting our skin to age

(A) Wrinkle

- UVR causes wrinkle and melanin to form.

- UVA penetrate into the dermis to damage the collagen.

- UV induce production of free radical (O2) species (ROS) & matrix metalloproteinases

(MMP)

- (O2) present in our cell can form harmful radical (ROS).

The Ageing Process

UVA penetrate into dermis –

damage collagen

ROS

ROS

ROS

MMP

MMP

MMP

The Ageing Process

ROS

ROS

MMP

MMP

MMP

Antioxidant attenuates the ROS & MMP & allow skin to regenerate properly

Antioxidants

Anti-oxidants

Anti-oxidants

Anti-oxidants

SUPERFOODS ! FOR BEAUTY ON THE INSIDE OUT

3-in-1 formula

(Radiant Skin + Breast Firming + Antioxidant)

Perfect Combination Of

PRESENTING…

BEUCOGEN COLLAGEN(Product Benefits)

1. Repair body cell

2. Improve skin fairness

3. Restore skin cell elasticity

4. Reduce fine lines & pigmentation

5. Retain skin moisture content

6. Smoothen skin

7. Eliminate free radicals

8. Prevent cell oxidation

9. Firm up breasts

10. Antioxidant

Active Ingredients

(For Skin)

Hydrolysed Marine Collagen• Collagen is main protein surrounding every cell. 6% of body weight.

• Collagen is one the long, fibrous structural protein.

• Main component of cartilage, ligaments, tendons, bone & skin.

• Made up of three polypeptide strands, twisted together & stabilized by hydrogen bonds

• More than 28 types of collagen. Over 90% of collagen are of type 1,2,3,&4

• Collagen 1- skin, tendon, vascular, ligature, organ , bone

• Collagen 2- cartilage

• Collagen 3- reticular fiber found in artery walls, skin, intestines & uterus

• Collagen 4 – form bases of cell basement membrane

• After age 25, collagen synthesis reduce at a rate of 1.5% and reduce into half after age of 60, skin become thinner & less firm

• Characteristics of marine collagen in Ladies Collagen:-

* Marine Low Molecular Collagen

* Average Molecular Weight 3,000Da – the lighter the molecular weight (< 5,000Da) increases absorption.

* High solubility

* High digestion by human enzyme

* Low moisture absorption

* Less fish smell & taste white fine powder.

* Easy handling

(3,000mg)

L-Arginine• Key building block to repair damaged tissue & bone

• Improve blood circulation

• Help in wound healing

• Positive immune modulating – anticancer effects

• Generate muscle mass

• Reduce body fat

(200mg)

L-Lysine

• Amino acid for growth & tissue repair

(one of the nine essential amino acid which the body can’t produce ourselves, have to take from food)

• Produce antibodies, hormones, enzymes, collagen formation

• Assist calcium absorption

• Lowering cholesterol

(200mg)

Active Ingredients

(Firming)

Soy Extract (Isoflavonoid)

• Isoflavones = phytoestrogen(plant hormone) which resembles human estrogen in chemical structure.

• Functions to firm skin & breast and balancing the hormone.

• Contain 40% isoflavonoid which helps in :

- Prevention of breast cancer- Prevent osteoporosis- bone- Ease menopause symptoms – hot flushes- Reduce heart disease risk

(200mg)

Soy Protein

• High source of protein which subsequently increases our protein in the body

• Functions to provide protein to rebuild cell

(2,000mg)

Oligo (oligosaccharides )

• Decrease gastrointestinal transit time

• Helps to encourage the growth of friendly bacteria

• Improves constipation & diarrhea

(2,400mg)

Active Ingredients

(Antioxidant)

• An antioxidant as it protects the body against oxidative stress • Vitamin C in combination with collagen, allows the collagen

molecule to assume its triple helix structure and making vitamin C essential to the development and maintenance of scar tissue, blood vessels, and cartilage.

Vitamin C

Sources of Vitamin C :

Citrus Fruits eg. Oranges, grapefruitRose hips are particularly high in

vitamin C

(50mg)

Manufacturing Flow Chart

(Marine Collagen)

Marine Hydrolyzed collagenMarine Hydrolyzed collagen

Spray DryingSpray Drying

SterilizationSterilization

ConcentrationConcentration

FiltrationFiltration

Enzymatic HydrolysisEnzymatic Hydrolysis

PurificationPurification

Extraction (by hot water)Extraction (by hot water)

Acid treatmentAcid treatment

DegreasingDegreasing

100% fish skin (bone, skin, cartilage, scale)100% fish skin (bone, skin, cartilage, scale)

ENZYMATIC HYDROLYSIS:1) SHORT CHAIN PEPTIDES2) LOW MOLECULAR WEIGHT,3000D3) NO FISHY ODOUR 4) NEUTRAL TASTE5) GOOD SOLUBILITY IN WATER6) CLEAR SOLUTION7) HIGH AMINO ACID PROFILE

Double Blind Placebo (Clinical Evaluation)

Examining for :

1) Moisture content of skin surface

2) Skin elasticity

3) Flexibility of skin

4) Microscopic 3D skin surface analysis

5) Statistical analysis – the difference before and after (Non-parametric Mann-Whitney test with placebo)

(P-value of less than 0.05 was taken as significant difference)

Double Blind Clinical Evaluation

• 21 women

• Age 13.3 – 34.1 years old

• Dry & rough skin

• Drinks 5g of Collagen per day for 4 weeks

Test Result : Moisture content

0

5

10

15

20

25

30

35

40

45

mo

istu

re c

on

ten

t%

MM placebo

before after 2 weeks after 4 weeks

This shows the increase of moisture

content of skin surface by approx.

60%

Test Result : Flexibility of Skin

0

0.05

0.1

0.15

0.2

0.25

0.3

0.35

flexi

bilit

y %

MM placebo

before after 2 weeks after 4 weeks

This shows that the flexibility of skin had

increased by approx.

48%

Before treatment

After 4 weeks treatment

Test Result : Microscopic Skin Surface Analysis

BEFORE

AFTER

Conclusion – Test Analysis

• Increase of moisture content

• Increase of skin flexibility

• Improvement of skin conditions

• Certificate of safety - no side effect was observed

CERTIFICATION

2) HALAL CERTIFIED

3) HACCP CERTIFICATION 4) GOOD MANUFACTURING PRACTICE

5) ISO CERTIFIED

CONTACT DETAILSZENOTEC PHARMA (M) SDN. BHD.

+603- 5122 3050

No.34-2, Jalan Anggerik Vanilla R31/R,40460 Shah Alam,Selangor Darul Ehsan

zenotec@ymail.com

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