TO DO Life Sciences stands for highly experienced consulting-and engineering competence in the sector of GMP–compliant designed plants.

Think result - oriented,

act precisely ... reach your goals

TO DO Group

TO DO Solutions areas of expertise:

→ building design

→ manufacturing construction

→ business development

→ utility engineering i.e.HVAC, steam generators,environmental accessories,chilled water systems,air pressure systems

TO DO Life Sciencesareas of expertise:→ process development → plant and pipe planning → clean room technologies → validation of plants and

processes for LS industries → creation of documentation as

PID’s, user requirements,isometries, IQ, OQ and PQdocumentation

→ project management and engineering for LS industries

Jelfa SA, Jelenia Gora, Poland / Jacobs Engineering, Milano, Italy2 production lines 1600L, 1000L (Class C / D) for non sterile dermatological products2 production lines 1000L, 500L (Class A / D) for sterile dermatological poductsengineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

References Pharmaceutical Industry Semi Solidal Products

Alza Ireland Ltd, Tipperary, Ireland 1 production vessel 1000L with glove box (Class A) for the production of high viscous active agent combinationengineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

A. Nattermann & Cie – sanofi aventis Gruppe, Köln, Germany 1 production line 2000L for the production of high viscous lecitin ethanol mixture (Eex)engineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

PharmaVision San. Ve Tic. A.S. former Hoechst, Istanbul – Topkapi, Turkey1 production line 2000L for the production of semi solidal creams and ointmentsengineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

Cross Vetpharm Group Ltd., Dublin, Ireland2 production lines 2000L each for the production of semi solidal veterinarien creams and ointmentsengineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

Chiesi farmaceutici S. P. A., Parma, Italy / Jacobs Engineering, Milano, Italy1 production line 2500L, (Class A / B / D) with glove box for pharmaceutical dispersions and solutions (athma bronchiale)engineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

References Pharmaceutical Industry Liquid Products

Polfa Warszawa S.A., Warschau, Poland / Jacobs Engineering, Milano, Italy4 production lines (Class C / D) 1000, 800, 500, 500L for dispersions and solutions (eye, nasal drops and suspensions) engineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

Bayer HealthCare A.S., Istanbul, Turkey1 production line 250L (Class D) for the production of tablet lacquersengineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

Chinoin® Pharmaceutical Products, S.A DE C.V , Aguascalientes, Mexico / Bayer Technology Services, Mexico 2 production lines 1000L (Class D / B / A) for the production of sterile injectables (solutions and dispersions)engineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

Lohmann & Rauscher GmbH & Co. KG, Neuwied, Germany1 production line 2000L (Class D) for the production of collagen suspensionsengineering, project management, pre qualification of suppliers for main components, commissioning, qualification, validation

Bayer MaterialScience AG, GermanyDesign concept for the Relocation of site production facilities (High Tech Chemicals, Toxic Agents, Additives for Research Institutes) - Material Flow and production logistics design - Conceptional design – cost estimation – basic engineering (area ~ 7.500m²)

References Site Assessment and Site development

Bayer AG – Administration - Production and Research Facility, UAE United Arabian Emirates Site concept – basic engineering – project management for a regional head quarter, production-, laboratory and research facility for Bayer MaterialScience and Bayer HealthCare (area ~ 21.000m²)

PetFood Manufacturer, EuropeDesign concept for the redevelopment and expansion of the site ( Material Flow -logistics design - Conceptional design –basic engineering – detail engineering – project management (area ~ 40.000m²)

References Site Development and Site Relocation

Bayer Material Science AG – Administration - Production and Research Facility, Dubai, UAE Site concept – basic engineering – project management for a production-, laboratory and research facility (area ~ 22.000m²)

Colgate Palmolive – Production facility for dental toothpaste, Europe Site concept – basic engineering – project management for a plant and warehouse extension (area ~ 2.000m²)

Linamar Coproration– Administration - Production and Laboratory Facility, Saxonia, Germany Site concept – basic engineering – project management for a new administration production and laboratory facility (area ~ 25.000m²)

Bayer Material Science AG – Administration - Production and Research Facility, Noginsk, Russia Site concept – basic engineering - for a production-, laboratory and research facility (area ~ 22.000m²)

Bayer Material Science AG – Administration - Production and Research Facility, Noida , India Site concept – basic engineering – project management for a production-, laboratory and research facility (area ~ 20.000m²)

Bayer Material Science AG – Administration - Production and Research Facility, Bangpoo, ThailandSite concept – basic engineering – project management for a production-, laboratory facility (area ~ 7.000m²)

Bayer Material Science AG – Administration - Production and Research Facility, Guangzhou, ChinaSite concept – basic engineering – for a production-, laboratory and research facility (area ~ 35.000m²)

References Site Development and Site Relocation - continued

Linamar Corporation – Administration - Production and Laboratory Facility, Wuxi, China Site concept – basic engineering – project management: administration, production- and laboratory facility (area ~ 31.000m²)

IFAM Fraunhofer Institut für Angewandte Materialforschung – Research facility, Bremen Germany Basic engineering – project management for relocation of technical services (area ~ 2.000m²)

Houghton Deutschland GmbH – Administration - Production and Research Facility, Wuppertal, Germany Site concept – basic engineering – detail engineering for a production-, laboratory and research facility (area ~ 14.000m²)

Houghton International Inc. – various production facilities in EuropeSite concept – relocation concept - basic engineering - for a varios production- and laboratory facilities

LEXIN International B.V.– Administration - Production and Research Facility, Buchen, Germany Site concept – basic + detail engineering – project management: administration, production- and laboratory facility(area ~ 7.500m²)

Bayer Material Science AG – HVAC Design for Office, QA/QC – Technical + Research LaboratoriesBasic engineering + Detail engineering +project supervision: HVAC + Chiller Systems, Laminar Flow systems, Fume Hoods, HEPA + ULPA Filtration:for projects in: India, Thailand, Russia, UAE, Greece, China

References GMP/HSE Utilities –HVAC - Process Ventilation

Heristo AG – Human Food Processing Plant – Hygienic and GMP design Conceptual design, basic engineering + detail engineering +project supervision and execution: process vacuum ventilation and vacuum system, filter and air srubber systems

Petfood Manufacturer – Process Ventilation systems for various process room systems Conceptual design, basic engineering + detail engineering +project supervision

Bayer Material Science – Process Ventilation + Air scrubber systems (Additive Rooms Storage of dangerous materials) Conceptual design, basic engineering + detail engineering +project supervision for projects in: Germany, India, Thailand, Russia, UAE, Greece, China .

Houghton International – Process Ventilation + Air Scrubber systems for chemical production facilities basic engineering + detail engineering +project supervision for projects in: Germany,

Thermal Oil Systems (Wärmeträgerölanlagen) Basic engineering + Detail engineering +project supervision for various projects up to 1.750 KW

References for Utilities – Heating – Cooling - Process Fluids

Steam Heated Autoclave Systems for product sterilisation for various projects

Cleaning in Place (CIP) systems for process equipment for various projects

Sterilisation in Place (SIP) periphery for process equipment for various projects

Cooling Towers for cold water system for various projects (up to 750 kW )

Chilled water systems for various projects (up to 1000 kW)

Compressed Air (oil free – dry air systems ) for various projects (up to 750 kW)

Technical Gases (nitrogen, oxygen etc.) for various projects

Active and Passive Fire Protection systems (sprinkler, foam, gas and other systems) for various projects

Medium Voltage Systems (switchgear and transformers) Basic engineering + Detail engineering for 6kV, 10 kV, 20 kV systems (up to 8000 kVA) for various projects

References for Utilities – Electrical and Automation Systems

Low Voltage Systems (switchgear, cable and routing systems, electrical installation technology) Basic engineering + Detail engineering up 4000 kVA per low voltage system for various projects

Lighting Installation (GMP compliant lighting systems) Lighting calculation, Basic engineering + Detail engineering for various projects

Totally Integrated Automation Systems (Field Technology, PCS Systems, HMI Systems) Bus Systems, PLC and PCS Systems, WIN CC, PCS 7, basic and detail engineering for various projects up to 10.000 I/O

Measuring and Control Technology (Field sensors, transmitters and Controllers) Volume Flow Meter, Mass Flow Meter, Pressure + Differential Pressure, Temperature, ph Value, Conductivity, Level Measurement, Online Corrosion Monitoring, Closed loop control systems (PID Regler, Non linear controllers)

Lightning Protection systems (Inner – and outer lightning protection, surge protection systems)

Grounding systems (Foundation earthing, equipotential bonding)

Fire alarm systems (VDS konform, NFPA, FM Global)

CAD-Tools:Autodesk Inventor 2010 & Routed Systems Suite (3D-CAD with functions for piping) Autodesk AutoCAD (2D-CAD)Autodesk Revit Architecture Suite (3D-CAD for parametric architectural shaping)McNeel Rhinoceros (3D- Design for freeforms)McNeel Flamingo Renderer for Rhino, (Raytracing and Radiosity)

Software Factory pressure loss for calculation of pressure lost in pipingsSiemens Simaris Design power distribution Software (flow sheets, Electrical Engineering)ePlan (CAE Software, Electrical Engineering) Microsoft Project (time schedules for project management)RIB Software AG ARRIBA (Software for bidding documents)

Engineering Tools:

Netviewer one2meet (Online Conference Software)Cowimas (Know-how- and Contentmanagementsystem on data bank basis)Adobe Photoshop (Image Processing)Adobe Illustrator Version (Drawing Program for Illustrations on vector basis)

Office Tools:

Our Team works with

Contact:

TO DO Life Sciences GmbH & Co. KG

BUSCHHÖHE 8D-28357 BREMEN

PHONE: +49 (0) 421 986 000 00FAX: +49 (0) 421 986 000 18

E-MAIL: info@todo-lifesciences.de INFO: www.todo-lifesciences.de

Thank you very much for your time!

We thank the VAKUMIX AG for the provision of the photographs of the processing plants and the specimen documents