tmmy_cr and bcd_academy 2009-00b

8/13/2019 Tmmy_CR and BCD_Academy 2009-00b

1/18

Case Study II

Modular Bio Containment facility

BSL 3 Seed LabThomas [email protected]+49 172 610 11 81


2/18

The Case

BSL 3 Seed Lab Client is Confidential Location: Europe Reasons to choose modular approach:

Fast track realisation, start up before the next vaccination campaignstarts in autumn

Removable building: in case of an outbreak, the building could be

moved to e.g. Spain


3/18

Overview

BSL 3 Seed Laboratory within 6 months


4/18

Planning (artist view made by our visualisation department)

Realisation

. .


5/18

Layout, Cleanroom classes


6/18

Layout, pressure levels


7/18

Shell in shell system


8/18

Construction


9/18

Requirements

Several regulations have to be considered in the design:e.g. DIN/EN Norms, GenTSV, EN 1717, DIN 1946 part 7, ..

First objective: protection of the staff and environment

Method: Disinfections, HAVC, procedures, Controlled access Method: Locked doors and windows, interlocking, card reader, code

switches

Person protection by visible workplaces Method: doors with windows, walls with windows

Smooth surfaces, easy to clean Method:pool design, pvc welded on floors and wall, trespa ceiling

Personnel safety equipment

Safety procedures Method: SOPs, touch less taps, emergency shower, eye shower, towel

and disinfection dispenser


10/18

Requirements

Waste treatment Method: double door decontamination autoclave, kill tank, H13 filters

Disinfection of working table tops

Method: curb on table tops, water retention on the floor, no floor drains Fire protection

Method: F90 Building, F30 Windows, fire extinguisher, no sprinkler,floor curb at the entrance, problem to keep underpressure

Drinking water protection Method: water line separation valve

Hermetic closure of the building in case of an emergency fumigation

Emergency power supply for ventilation, illumination, emergency call andcommunication systems Two escape routes


11/18

Decontamination Autoclave

Media connectionsMinimised, centralised,In separate insulated panels

roomsPVC on walls and floor,Trespa on the ceiling

roomsFumigation with H2O2, triple

glas windows,Shell-System fumigation withformaldehyde


12/18

HVAC


13/18

Police filter H13Fumigation withformalin

Waste air incinerationFor kill tank

Pressureregulator

For small roomswith a water valve

Volume control valvesAll installed in the technicalarea

Shell-Filter H13

Fumigation with formalin


14/18

Fumigation with H2O2

Disinfection procedure 10 pages word document! VHP compatibility: Steris-Bioquell(see also: http://www.bioquell.com/)


15/18

Time schedule


16/18

Time Schedule


17/18

Cost benchmarks

Transport;

50.000,00;

4%

Engineering

/ Hours;

185.000,00;

13%

Equipment;

1.184.725,0

0; 83%

Modules;

620.000,00;

52%

HVAC;

350.000,00;

30%

Waste

Water

Treatment;

96.500,00;8%

Decontamin

ationAutoclave;

82.500,00;

7%

Monitoring;

30.925,00;

3%Lab

Furniture;4.800,00;

0%

1,4 Million Euro

5,400 /m


18/18

Questions ?

tmmy_cr and bcd_academy 2009-00b

Documents