The polymerised fractionfrom bilberry with proven efficacy.

A CLINICALLY PROVEN ACTION AS VASCULAR PROTECTOR

Catocyanic Complex®belongs to the flavonoid family.Its vasoprotective properties have been demonstrated bypharmacology studies in various experimental models.The mechanism proposed to explain this activity is basedon the participation of collagen in the vessel wallin the control of vascular permeability.Catocyanic Complex ® interacts with collagen, increases itsreticulation and hence decreases vascular permeability.Catocyanic Complex ® proved to play a beneficial rolein venous and capillary disorders and theircomplications such as:

• Lymphedema*• Varicose and spider veins*• Heavy legs and leg edema of venous origin*• Bruises, petechiae, vasculitis *• Couperose*

* These statements have not been evaluated by the Food and Drug Administration.Catocyanic Complex is not intended to diagnose, treat, cure or prevent any disease.

Thanks to a natural friendly fermentation process (no added SO2) the nutritive andactive properties of the compound are preserved. Accurate chemicals, physical andmicrobiological tests are performed in house according to pharmacopeias and cGMP.

Our unique extraction process allows the genins to polymerise together, cuttingout the molecule of sugar. For this reason, the final compound is paticularly suitablefor diabetic needs.

EXTRACTION PROCESS

Catocyanic Complex® is an active polymerised fraction extracted from bilberrycomposed of aglycon cyanidins, delphinidine, malvidine and peonidine.

WHAT IS CATOCYANIC COMPLEX®

R1 = OHR2 = H, OH or OMe(Me = Methyl: -CH3)

HO

OH

O+

OH

R2

R1

R

n

Catocyanic Complex® inhibits the degradationof collagen.It protects the vascular wall from the actionof collagenase (1,2,3,4).

ACTION ON COLLAGEN

CATOCYANIC COMPLEX® MECHANISMS OF ACTION

Catocyanic Complex® inhibits the enzymatic activityof elastase (5).Elastase is a proteolytic enzyme which plays a rolein the deterioration of connective tissues and elastic fibersand is involved in certain vascular disease conditions.

ACTION ON ELASTASE

Catocyanic Complex ® limits the thickening of the vesselbasal membrane, decreases capillary permeabilityand strengthens the capillary wall (6,7,8)

ACTION ON CAPILLARY PERMEABILITY

Catocyanic Complex ® improves capillary resistancein subjects suffering from bruises and/or petechiaein venous and lymphatic disorders (9,10,11,12)

ACTION ON CAPILLARY RESISTANCE

50

0

100

ELAS

TASE

ACT

IVIT

Y

0,1 0,2 0,4 0,8

ba

0,2 0,4 0,8 1,6

c50

0

100

INHIBITORS (mg)

Destructionof collagen

Abnormalpermeability

Decreaseof resistance Resistance

is enforced

Permeabilitybecomes normal

CATOCYANICCOMPLEX®

FIBERS OF COLLAGEN

This figure shows a: vitis vinifera,b: ccomplex, c: pinus marittimus

and their inhibitning poweron the elastase

CATOCYANIC COMPLEX BENEFITS

Thanks to its special mode of action, and its ability in repairing changes in the venous wall, Catocyanic Complex is commonly used to:• Improve capillary and venular flow.• Maintain the integrity of the connective tissue surrounding the vessels by protecting collagen and elastic fibers.• Increase lymphatic flow.• Support general circulation.• Reduce edema and bruises by normalizing capillary permeability and facilitating the reabsorption of fluids.

1) Boniface R et al Pharmacological properties of Myrtillus anthocyanosides : correlation with results of treatment of diabetic microangiopathy. Flavonoïdsand bioflavonoids, ed. Farkas 1985 p 293301

2) Lagrue G., Robert A.M. et al Pathology of the microcirculation in diabetes and altérations of the biosynthesis of intercellular matrix macromolécules. Front.Matrix Biol 1979, Vol. 7, pp. 324335

3) Robert, Miskulin, Godeau, et al Action of anthocyanosides on the Permeabilityof the blood-brain barrier Front Matrix Biol 1979 vol 7

4) Boniface R, Robert AM Effect of antocyanes on human connective tissue metabolism Klin Monatsbl Augenheilkd Dec 96, 209 (6) 368-72

5) Jonadet, Meunier, Bastide Anthocyanoside extraits de Vitis Vinifera,de Vaccinium myrtillus et de Pinus Maritimus"J. Pharm Belg 1983

6) Cohen, Boulakia et al In Vivo Sequential study of skeletal muscle capillarypermability in diabetic rats: effect of anthocyanosides Metabolism July 2000 vol 49

7) Detre, Jellinek, Miskulin, Robert Studies on vascular permeability in hypertension : action of anthocyanosides Clin physiol biochem 1986

8) Miskulin, Detre, Jellinek Variation in vascular permeability in the initial phase of experimental hyperetension in the rat Paroi Arterielle 1980

9) Hiltgen, Guermonprez Modification de la résistance capillaire chez 40 diabétiques traités par les anthocyanoside de myrtille Extrait de la medecinepraticienne, sept 1972 P481

10) Salanova Action des anthocyanoside de myrtille sur la resistance capillairedes obeses et des diabetiques Medica sept 1972

11) Amouretti Interet therapeutique des anthocyanosides de Vaccinium Myrtillusdans un service de medecine interne Extrait de therapeutique 1972

12) SevinR., Guendet J.F. Effet d'une association d'anthocyanosides sur la résistance capillaire des diabétiques. Ophtalmologia 152, 1966 p 109117

Catocyanic Complex is already being used in a prescription drug for venous disorders (Difrarel 100) and in a cream formulationfor heavy leg (Antoven)

ALL THE STUDIES ARE

PERFORMED WITH

CATOCYANIC COMPLEX

7th Floor - Hume house - Ballsbridge - Dublin 4 IrelandTel. +353 1 2845434 - Fax +353 1 2764707E-mail: info@medpharma.ie

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