[ xevo TQ ms ]

The onLy ThIng IT doeSn’T do IS coMproMISe.

Xevo TQ MS delivers new levels of sensitivity for all the analytes in your sample. It combines MassLynx™ MS Informatics with innovative ScanWave™ and IntelliStart™ technologies to deliver versatility and superior quantitative capability to the widest range of scientists.

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Developing life-saving medicines. Safeguarding

drinking water and the environment. No matter

what your unique application is, your need is

universal. You require robust, accurate, high-quality

information quickly and easily. No compromises.

The solution? The Engineered Simplicity™ of

Xevo™ TQ MS. This innovative tandem quadrupole MS system is engineered to provide

superior performance and unparalleled usability.

You’ll have immediate access to maximum HPLC

and UPLC®/MS/MS performance – for unmatched

speed, exceptional quantitative analysis, and the

very best chromatographic resolution. You’ll also get

simplified set-up and intelligent informatics

allowing you to make better decisions faster.

Xevo TQ MS is ready for your most complex quantitative challenges. Which means you’ll be

ready to take your analytical research to the next level.

What’s more, you’ll see a return on investment

right away.

[ FoLIo INsIDe HeADeR ][ xevo TQ ms ]

TAkIng Lc/MS/MS perforMAnce To neW LeVeLS of eXceLLence

Xevo TQ MS System

Greater accuracy. Increased sensitivity. Maximum productivity.

Are your business or research objectives held back by your instru-

ment’s inability to reliably quantify the analytes of interest in your

complex sample matrices?

Xevo TQ MS is the answer. Its innovative technology provides

enhanced selectivity, sensitivity, and linearity through novel develop-

ments in ion source technology; a unique ScanWave collision cell and

new information-rich acquisition modes. With these improved capa-

bilities, you can easily quantify and confirm trace components, even

in highly complex matrices, with unparalleled speed and accuracy.

Next generation API Sources

Xevo TQ MS is equipped with a new family of atmospheric pressure

ionization sources for analysis of the widest range of compounds

possible. These new ion sources benefit from a number of innova-

tions, including optimized gas flow dynamics and enhanced thermal

desolvation, which vastly increases the efficiency of ionization.

n ESI/APCI/ESCi® n APPI/APCI n Nano-flow ESI

The next genera-tion ZSpray™ API source redefines the boundaries of LC/MS performance

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purpoSefuL InnoVATIon

R o B U S T , P R e C I S e I N F o R M A T I o N . F A S T . With the growing demand for viable drug candidates, increased

safety measures for our food supply, and better quality data for

forensic laboratories, you need an instrument with advanced speed,

sensitivity, and selectivity. You also need it to be accessible to all

levels of scientists.

That’s the very definition of Xevo TQ MS and its Engineered

Simplicity. Xevo TQ MS is engineered with the ultimate combination

of high performance and accessibility. It adds simplicity throughout

your workflow – from system set up to monitoring long-term

analytical performance – while helping you solve your specific chal-

lenges in a very specific way. With Engineered Simplicity working

for you, you can bring drugs to market faster, identify a broader

array of food contaminants, or report reliable forensic data with

total confidence.

Simplifying your system setup.

IntelliStart Technology is user-friendly technology that allows you

to reduce the burden of complicated operation and time-intensive

troubleshooting. Both novice and experienced scientists alike can

operate the instrument quickly and produce the highest quality

UPLC/MS/MS data consistently.

IntelliStart Technology automatically:

n Ensures your system is ready for use

n Performs mass calibration and sets MS resolution so you

don’t have to

n Achieves the very best detection limits by generating com-

pound-specific MS methods (SIR or MRM) and optimizing API

source conditions for your specific analytical conditions

Simplifying your method creation.

Xevo TQ MS includes Quanpedia,™ a new extensible and searchable

database for quantitative LC/MS method information. Each entry in

Quanpedia is populated with information that associates compound

name with details of optimal SIR/MRM acquisition methods, accept-

able confirmatory ion ratios, appropriate LC methods, and expected

peak retention times.

For fast-paced, multi-user environments, Quanpedia offers you a

simple and convenient way to rapidly create complete LC/MS data

acquisition and processing methods, so your scientists can concen-

trate on the real job at hand: creating real solutions to real problems.

Rapidly acquire data on a large number of compounds in a single run.

Xevo TQ MS is designed specifically to minimize your sample run

time and maximize the number of compounds you can reliably assay

in a single method. It delivers enhanced compatibility with UPLC

Technology by operating optimally at the highest data acquisition rates.

To accurately quantify the narrow peak widths of UPLC Technology

(around two to three per second), fast acquisition speeds of 15 to 20

data points per peak are required. Traveling Wave1 collision cell tech-

nology (T-Wave™) minimizes source-to-detector ion transit times for

high-speed data acquisition, ensuring optimal MS/MS performance no

matter how rapidly data needs to be acquired.

The Xevo TQ MS allows you to detect basic and acidic compounds in

a single analysis through its ability to switch between positive and

negative ionization in only 20 milliseconds. Why do two assays when

you can get the reliable data you require from just one?

Unrivaled versatility and performance.

Have you considered the real impact of high-quality spectral

information on your results?

Unlike conventional tandem quadrupole mass spectrometers,

Xevo TQ MS is designed to not only provide the very best quantita-

tive data, but also to provide you with superior spectral MS/MS

information. Xevo TQ MS offers you much more versatility in a

single instrument platform that is adaptable to a variety of different

UPLC/MS/MS applications – both quantitative and qualitative. With

the flexibility to broaden your experimental choices, you’ll quickly

maximize your return on investment.

Although conventional tandem quadrupole mass spectrometers are

very sensitive when used to monitor single masses (i.e., in MRM

mode) they are significantly less sensitive when used to acquire

multiple analytes and UPLC/MS/MS data in a spectral mode.

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A N y T H I N G e L S e J U S T I S N ’ T A N o P T I o N .

n Ready to run

n Resolve system alerts

n Auto tune and calibrate

n Auto develop methods

n LC/MS/MS system check

Automating your quality control.

QC Monitor™ is a new automated tool that provides “on time” quan-

titative data quality monitoring to determine whether a QC or blank

sample is within tolerances specified by the user. QC Monitor will

decide whether subsequent samples should be injected or whether

more detailed checks are required, ensuring the very best use of

your laboratory resources.

Real time monitoring of QC and blank sample data by the Xevo TQ

MS prevents unnecessary wastage of your samples, given that they

take time to extract and prepare.

With TargetLynx™ Software, the process of quantitation is simpler

than ever. The results browser and report generator clearly indicate

when samples contain residues or drugs of abuse that are above the

minimum reporting levels. TargetLynx Software reporting includes

a wide range of automated QC and confirmatory checking so poten-

tially thousands of calculations and comparisons are performed

automatically to significantly improve your laboratory workflow.

Through the unique design of its collision cell, Xevo TQ MS enables

you to better address your analytical needs with the option to

operate in T-Wave enabled mode or in a new ScanWave enabled

mode. ScanWave is an innovative technology that allows ions within

the collision cell to be accumulated and then separated according to

their mass-to-charge ratio (m/z). Synchronizing the release of these

ions with the scanning of the second quadrupole mass analyzer

greatly improves duty cycle, which significantly enhances the signal

intensity of full scan product ion spectra. Simply put, this enables

you to more easily confirm the identities and structures of the

analytes you’re interested in.

Unique T-Wave- and ScanWave-enabled collision cell technology for the very best MS/MS data.

MS/MS spectral enhancement provided by ScanWave technology (a product ion spectrum of Glu-Fibrinopeptide, acquired at a scan speed of 5000 amu per second).

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IntelliStart Technology controls sophisticated on-board fluidics, introducing reference

solutions for automated MS setup.

Monitoring long-term system health.

The new TrendPlot tool provides confirmation that LC/MS/MS results

generated by your laboratory are consistently of the highest quality by

charting short-term intra-batch, and long-term inter-batch trends in

your analytical performance.

Maximizing your system uptime with Waters Connections INSIGHT.

Connections INSIGHT® is an intelligent service delivery platform

that provides continuous monitoring and instant-alert notifications for

faster, proactive support that virtually eliminates downtime

due to hardware failure.

See the whole picture when performing targeted quantification.

Dual Scan-MRM acquisition mode: The ScanWave Collision Cell

design allows you to acquire full scan MS (and MS/MS) and multiple

reaction monitoring (MRM) data in parallel during a single analyti-

cal run without compromising performance. This information-rich

acquisition approach gives you an advantage particularly during

method development, where it can provide you with the ability to

visualize the full sample matrix. You’ll be able to screen your sample

for metabolites, degradants, and impurities at the same time as

performing targeted quantitation at trace levels.

And because you’ll always have an insight into potential matrix interfer-

ences, you can take earlier action to avoid or measure their effects.

Together, the new API sources, the T-Wave-enabled collision cell,

and the rapid multi-mode switching capability allow you to take full

advantage of UPLC/MS/MS benefits. The combination of ACQUITY

UPLC® Technology and Xevo TQ MS forms a technologically-advanced

UPLC/MS/MS system solution – providing unmatched speed, the low-

est limits of quantitative analysis, and the very best chromatographic

resolution. So your laboratory can deliver all of the quality data

requirements necessary to maximize business opportunities.

Parallel acquisition of MRM and full scan data in the same run.

Dual Scan-MRM Mode

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Waters Corporation 34 Maple StreetMilford, MA 01757 U.S.A.T: 508 478 2000F: 508 872 1990www.waters.com

www.waters.com/xevo

Waters, UPLC, Connections INSIGHT, ESCi, UPLC and ACQUITY UPLC are registered trademarks of Waters Corporation. The Science of What’s Possible, Xevo, Engineered Simplicity, MassLynx, ZSpray, ScanWave, IntelliStart, Quanpedia, QC Monitor, and TargetLynx are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.

©2009 Waters Corporation Printed in the U.S.A. January 2009 720002494EN PC-CP

References

1. The traveling wave device described here is similar to that described by Kirchner in US Patent 5,206,506 (1993).