Xevo TQ MS delivers new levels of sensitivity for all the analytes in your sample. It combines MassLynx™ MS Informatics with innovative ScanWave™ and IntelliStart™ technologies to deliver versatility and superior quantitative capability to the widest range of scientists.
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Developing life-saving medicines. Safeguarding
drinking water and the environment. No matter
what your unique application is, your need is
universal. You require robust, accurate, high-quality
information quickly and easily. No compromises.
The solution? The Engineered Simplicity™ of
Xevo™ TQ MS. This innovative tandem quadrupole MS system is engineered to provide
superior performance and unparalleled usability.
You’ll have immediate access to maximum HPLC
and UPLC®/MS/MS performance – for unmatched
speed, exceptional quantitative analysis, and the
very best chromatographic resolution. You’ll also get
simplified set-up and intelligent informatics
allowing you to make better decisions faster.
Xevo TQ MS is ready for your most complex quantitative challenges. Which means you’ll be
ready to take your analytical research to the next level.
What’s more, you’ll see a return on investment
right away.
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TAkIng Lc/MS/MS perforMAnce To neW LeVeLS of eXceLLence
Xevo TQ MS System
Greater accuracy. Increased sensitivity. Maximum productivity.
Are your business or research objectives held back by your instru-
ment’s inability to reliably quantify the analytes of interest in your
complex sample matrices?
Xevo TQ MS is the answer. Its innovative technology provides
enhanced selectivity, sensitivity, and linearity through novel develop-
ments in ion source technology; a unique ScanWave collision cell and
new information-rich acquisition modes. With these improved capa-
bilities, you can easily quantify and confirm trace components, even
in highly complex matrices, with unparalleled speed and accuracy.
Next generation API Sources
Xevo TQ MS is equipped with a new family of atmospheric pressure
ionization sources for analysis of the widest range of compounds
possible. These new ion sources benefit from a number of innova-
tions, including optimized gas flow dynamics and enhanced thermal
desolvation, which vastly increases the efficiency of ionization.
n ESI/APCI/ESCi® n APPI/APCI n Nano-flow ESI
The next genera-tion ZSpray™ API source redefines the boundaries of LC/MS performance
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purpoSefuL InnoVATIon
R o B U S T , P R e C I S e I N F o R M A T I o N . F A S T . With the growing demand for viable drug candidates, increased
safety measures for our food supply, and better quality data for
forensic laboratories, you need an instrument with advanced speed,
sensitivity, and selectivity. You also need it to be accessible to all
levels of scientists.
That’s the very definition of Xevo TQ MS and its Engineered
Simplicity. Xevo TQ MS is engineered with the ultimate combination
of high performance and accessibility. It adds simplicity throughout
your workflow – from system set up to monitoring long-term
analytical performance – while helping you solve your specific chal-
lenges in a very specific way. With Engineered Simplicity working
for you, you can bring drugs to market faster, identify a broader
array of food contaminants, or report reliable forensic data with
total confidence.
Simplifying your system setup.
IntelliStart Technology is user-friendly technology that allows you
to reduce the burden of complicated operation and time-intensive
troubleshooting. Both novice and experienced scientists alike can
operate the instrument quickly and produce the highest quality
UPLC/MS/MS data consistently.
IntelliStart Technology automatically:
n Ensures your system is ready for use
n Performs mass calibration and sets MS resolution so you
don’t have to
n Achieves the very best detection limits by generating com-
pound-specific MS methods (SIR or MRM) and optimizing API
source conditions for your specific analytical conditions
Simplifying your method creation.
Xevo TQ MS includes Quanpedia,™ a new extensible and searchable
database for quantitative LC/MS method information. Each entry in
Quanpedia is populated with information that associates compound
name with details of optimal SIR/MRM acquisition methods, accept-
able confirmatory ion ratios, appropriate LC methods, and expected
peak retention times.
For fast-paced, multi-user environments, Quanpedia offers you a
simple and convenient way to rapidly create complete LC/MS data
acquisition and processing methods, so your scientists can concen-
trate on the real job at hand: creating real solutions to real problems.
Rapidly acquire data on a large number of compounds in a single run.
Xevo TQ MS is designed specifically to minimize your sample run
time and maximize the number of compounds you can reliably assay
in a single method. It delivers enhanced compatibility with UPLC
Technology by operating optimally at the highest data acquisition rates.
To accurately quantify the narrow peak widths of UPLC Technology
(around two to three per second), fast acquisition speeds of 15 to 20
data points per peak are required. Traveling Wave1 collision cell tech-
nology (T-Wave™) minimizes source-to-detector ion transit times for
high-speed data acquisition, ensuring optimal MS/MS performance no
matter how rapidly data needs to be acquired.
The Xevo TQ MS allows you to detect basic and acidic compounds in
a single analysis through its ability to switch between positive and
negative ionization in only 20 milliseconds. Why do two assays when
you can get the reliable data you require from just one?
Unrivaled versatility and performance.
Have you considered the real impact of high-quality spectral
information on your results?
Unlike conventional tandem quadrupole mass spectrometers,
Xevo TQ MS is designed to not only provide the very best quantita-
tive data, but also to provide you with superior spectral MS/MS
information. Xevo TQ MS offers you much more versatility in a
single instrument platform that is adaptable to a variety of different
UPLC/MS/MS applications – both quantitative and qualitative. With
the flexibility to broaden your experimental choices, you’ll quickly
maximize your return on investment.
Although conventional tandem quadrupole mass spectrometers are
very sensitive when used to monitor single masses (i.e., in MRM
mode) they are significantly less sensitive when used to acquire
multiple analytes and UPLC/MS/MS data in a spectral mode.
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A N y T H I N G e L S e J U S T I S N ’ T A N o P T I o N .
n Ready to run
n Resolve system alerts
n Auto tune and calibrate
n Auto develop methods
n LC/MS/MS system check
Automating your quality control.
QC Monitor™ is a new automated tool that provides “on time” quan-
titative data quality monitoring to determine whether a QC or blank
sample is within tolerances specified by the user. QC Monitor will
decide whether subsequent samples should be injected or whether
more detailed checks are required, ensuring the very best use of
your laboratory resources.
Real time monitoring of QC and blank sample data by the Xevo TQ
MS prevents unnecessary wastage of your samples, given that they
take time to extract and prepare.
With TargetLynx™ Software, the process of quantitation is simpler
than ever. The results browser and report generator clearly indicate
when samples contain residues or drugs of abuse that are above the
minimum reporting levels. TargetLynx Software reporting includes
a wide range of automated QC and confirmatory checking so poten-
tially thousands of calculations and comparisons are performed
automatically to significantly improve your laboratory workflow.
Through the unique design of its collision cell, Xevo TQ MS enables
you to better address your analytical needs with the option to
operate in T-Wave enabled mode or in a new ScanWave enabled
mode. ScanWave is an innovative technology that allows ions within
the collision cell to be accumulated and then separated according to
their mass-to-charge ratio (m/z). Synchronizing the release of these
ions with the scanning of the second quadrupole mass analyzer
greatly improves duty cycle, which significantly enhances the signal
intensity of full scan product ion spectra. Simply put, this enables
you to more easily confirm the identities and structures of the
analytes you’re interested in.
Unique T-Wave- and ScanWave-enabled collision cell technology for the very best MS/MS data.
MS/MS spectral enhancement provided by ScanWave technology (a product ion spectrum of Glu-Fibrinopeptide, acquired at a scan speed of 5000 amu per second).
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IntelliStart Technology controls sophisticated on-board fluidics, introducing reference
solutions for automated MS setup.
Monitoring long-term system health.
The new TrendPlot tool provides confirmation that LC/MS/MS results
generated by your laboratory are consistently of the highest quality by
charting short-term intra-batch, and long-term inter-batch trends in
your analytical performance.
Maximizing your system uptime with Waters Connections INSIGHT.
Connections INSIGHT® is an intelligent service delivery platform
that provides continuous monitoring and instant-alert notifications for
faster, proactive support that virtually eliminates downtime
due to hardware failure.
See the whole picture when performing targeted quantification.
Dual Scan-MRM acquisition mode: The ScanWave Collision Cell
design allows you to acquire full scan MS (and MS/MS) and multiple
reaction monitoring (MRM) data in parallel during a single analyti-
cal run without compromising performance. This information-rich
acquisition approach gives you an advantage particularly during
method development, where it can provide you with the ability to
visualize the full sample matrix. You’ll be able to screen your sample
for metabolites, degradants, and impurities at the same time as
performing targeted quantitation at trace levels.
And because you’ll always have an insight into potential matrix interfer-
ences, you can take earlier action to avoid or measure their effects.
Together, the new API sources, the T-Wave-enabled collision cell,
and the rapid multi-mode switching capability allow you to take full
advantage of UPLC/MS/MS benefits. The combination of ACQUITY
UPLC® Technology and Xevo TQ MS forms a technologically-advanced
UPLC/MS/MS system solution – providing unmatched speed, the low-
est limits of quantitative analysis, and the very best chromatographic
resolution. So your laboratory can deliver all of the quality data
requirements necessary to maximize business opportunities.
Parallel acquisition of MRM and full scan data in the same run.
Dual Scan-MRM Mode
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Waters Corporation 34 Maple StreetMilford, MA 01757 U.S.A.T: 508 478 2000F: 508 872 1990www.waters.com
www.waters.com/xevo
Waters, UPLC, Connections INSIGHT, ESCi, UPLC and ACQUITY UPLC are registered trademarks of Waters Corporation. The Science of What’s Possible, Xevo, Engineered Simplicity, MassLynx, ZSpray, ScanWave, IntelliStart, Quanpedia, QC Monitor, and TargetLynx are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.
©2009 Waters Corporation Printed in the U.S.A. January 2009 720002494EN PC-CP
References
1. The traveling wave device described here is similar to that described by Kirchner in US Patent 5,206,506 (1993).