The Kidneyyour bodies blood filter

The Kidney Ultrafiltration: filter the blood plasma

through the glomerulus and fenestrated capillaries

Increase in blood pressure in the glomerulus drives the filtration process

The fenestrations (slits) open up as blood flows through at high pressure

The basement membrane is not permeable to larger molecules, preventing things like protein enter the filtrate

The Kidney Osmoregulation is the homeostatic

process of controlling water levels in all tissues in your body

Why is it necessary?

Regulating the water levels will allow blood cells to remain in tact

The KidneyThe kidney is almost too good at filtering your blood… Much of what initially gets filtered out has to be returned

Most noteworthy substances to be reabsorbed: water, salts, glucose If water wasn’t reabsorbed you’d be peeing a lot more!

Much of reabsorption occurs via osmosis and diffusion, some via active transport (needs ATP)

The Kidney

The Kidney With ADH NOT available, water

stays in the filtrate/urine

With ADH present, water leaves, urine production decreases/becomes more concentrated

The Kidney

Diabetics can often have glucose in their urine

Not normal…typically 100% of glucose reabsorbed

Cotransport (active) of glucose against gradient has a capacity—too much glucose ends up in urine