the integumentary system normal skin, genetic defects, and scar formation
TRANSCRIPT
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The Integumentary System
Normal skin, Genetic Defects, and Scar Formation
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Cross section throughhuman skinKeratin
Stratified squamous epithelium
Dense irregular connective tissue
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Cross section through human skin
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Pacinian corpuscle (note the onion-like appearance)
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Meissner corpuscles located in the dermis
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Melanin producing melanocytes
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Genetic Abnormalities Associated with Skin
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Epidermolysis Bullosa
Fragile Skin, Blistering do toa defect in the adhesionmolecules that keepthe simple squamous epithelium together
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Ichthyosis – Scaly fish disorder
Harlequin Type 1 ichthysos
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Neurofibromatosis – defect on Chromosome 1. Autoosmaldominant disorder
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Incontinentia Pigmenti
X-linked disorder, often fatal in boys, causeshyperpigmentation of theskin, blistering, loss ofmotor function, delayedgrowth, mental impairment
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Albinism – A autosomal recessive genetic disorder in which the individualproduces no melanin. Albinism occurs in all species and races
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Simplified cross section of a hair
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Scar Formation
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Normal healing, epithelial cells move to the areaLittle or no fibroblast activity
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Mild hypertrophic scarring
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Mild keloid formation
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Keloid formation
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Cesarean section scars then and now
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Ritual scarification of the skin for religious or cultural reasons
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Scarification as body art / modification
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Diabetic ulcerationof the foot, notethe extensortendons of the foot