Falk Workshop

The Gut and the Liver

January 28 – 29, 2010CAESARCenter of Advanced European Studies and ResearchBonn, Germany

PreliminaryProgram

Application for CME credits submitted

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Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . 6

Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

List of Speakers . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

CME credits for the Falk Workshop have been applied for at the European Union of Medical Specialists (UEMS) – European Board of Gastroenterology (EBG). The number of credits awarded will be printed in the final program.

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Preface

The Gut and the Liver

Three large organ systems guarantee the direct exchange with our surroundings: the skin, the lungs and the intestine. This embeds us into the greater context of nature – below the level of consciousness.

Of these three, the gut is most important as an entry site for a multitude of different molecules of nutrition, as well as for microorganisms. They may pass the intestinal border and move to internal structures of our body where a new cross talk begins: be it benign or disease causing. One of the systems closely linked to the gut via the portal tract is the liver. The interlude between both with respect to immune response, induction of inflammation or change of metabolism is the topic of this workshop.

The gut is not only a window to our surroundings but also – via the epithelium and the attached immunological system – an active processor of molecules and organisms that contact or penetrate its luminal site. There are common mediators like bile acids or hormones that regulate both, the gut and the liver, and tune them to each other. These are further issues of the workshop.

Of course, the topic is vast and diverse and only flashlights can be covered by such a symposium. Nevertheless, we hope that it not only allows presenting some established and new concepts to the audience but also induces a fruitful discussion and some new ideas thanks to a group of well known lecturers and chairmen who have been kind enough to join us in Bonn.

I thank the scientific committee, Ulrich Beuers, Percy Knolle, Jacob Nattermann and Ulrich Spengler for their most valuable input in the planning of the program and we all are grateful to the Falk Foundation that allows us to continue the tradition of a premeeting to the German Association for the Study of the Liver (GASL).

Tilman Sauerbruch

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Falk Workshop

The Gut and the Liver

CAESARCenter of Advanced European Studies and ResearchBonn, Germany

The 26th Annual Meeting of the German Association for the Study of the Liver will follow the Falk Workshop:January 29, 12.30 toJanuary 30, 13.00 h

Scientifi c Organization:U. Beuers, Amsterdam (Netherlands)P. Knolle, Bonn (Germany)J. Nattermann, Bonn (Germany)T. Sauerbruch, Bonn (Germany)U. Spengler, Bonn (Germany)

Congress Venue:CAESARCenter of Advanced European Studies and ResearchLudwig-Erhard-Allee 253175 BonnGermany

Information:Prof. Dr. Tilman SauerbruchMedizinische Klinik IUniversitätsklinikum BonnSigmund-Freud-Str. 2553127 BonnGermanyTelephone: +49(0)228/28 71-12 49 +49(0)228/28 71-52 16Telefax: +49(0)228/28 71-46 98E-mail: tilman.sauerbruch@

ukb.uni-bonn.de

Offi cial Language:English

Call for Posters:For details see page 9

Publication date of fi nal program:January 2010

The fi nal program will be available on the homepage www.falkfoundation.org one week before.

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Thursday, January 28, 2010

11.00 Welcome lunch

12.00 Welcome T. Sauerbruch, Bonn

Session I Immune function Chair: P. Knolle, Bonn; J. Nattermann, Bonn

12.10 Immunology of gut and liver: A love/hate relationship D. H. Adams, Birmingham

12.40 Septic immune paralysis – Cross-talk between gut, A. Limmer, liver and spleen Bonn

13.10 Plasticity of dendritic cell function – Influence of gut A. W. Thomson, derived products Pittsburgh

13.40 Lunch break with poster session

Session II Biliary system Chair: G. A. Kullak-Ublick, Zurich; G. Paumgartner, Munich

14.30 Bile acids as mediators of the gut/liver interaction: A. Moschetta, The role of nuclear receptors Bari

15.00 Bile acids as mediators of the gut/liver interaction: P. L. M. Jansen, The role of hormones Amsterdam

15.30 The role of the intestine in the formation and F. Lammert, prevention of gallstones Homburg

16.00 The bile ducts in chronic inflammatory bowel disease U. Beuers, Amsterdam

16.30 Coffee break with poster session

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Thursday, January 28, 2010

Session III Metabolism (1) Chair: B. Siegmund, Berlin; M. V. Singer, Mannheim

17.00 Lipid metabolism: Cross-talk between the intestine and K. Schoonjans, the liver Lausanne

17.30 The intestine and fatty liver disease C. Hellerbrand, Regensburg

18.00 Gut barrier dysfunction and alcoholic liver disease R. K. Rao, Memphis

18.30 End of afternoon session

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Friday, January 29, 2010

Session IV Metabolism (2) Chair: U. Spengler, Bonn; W. Stremmel, Heidelberg

8.30 Drug metabolism: The gut and the liver M. Schwab, Stuttgart

9.00 Intestinal iron transport and liver disease M. Muckenthaler, Heidelberg

9.30 Gut-liver-brain axis: Consequences of liver dysfunction D. Häussinger, Düsseldorf

10.00 Coffee break with poster session

Session V The gut as entry site for microorganisms Chair: A. L. Gerbes, Munich; H. Tilg, Innsbruck

10.30 Bacterial translocation from the gut in liver cirrhosis A. Albillos, Madrid

10.50 Bacterial translocation and the response in the liver C. Trautwein, Aachen

11.10 Intestinal flora in liver cirrhosis: A therapeutic tool? R. Wiest, Regensburg

11.30 Tapeworm eggs: From gut to liver – Pathogenesis, P. Kern, prevention and treatment Ulm

12.00 Farewell U. Beuers, Amsterdam

12.10 Farewell lunch

12.30 Opening of the Annual Meeting of the GASL

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Poster SessionPosters will be exhibited on January 28–29, 2010, at the CAESAR Bonn.The authors will be in attendance during coffee and lunch breaks on both days.

Call for postersPlease submit your poster abstract before October 31, 2009. Only one-page abstracts not exceeding 250 words, written in English and saved in Microsoft Word format will be accepted.

Abstracts must be submitted via our Internet Abstract Submission System (http://www.falkfoundation.com/poster) where further information regarding the submission format and the submission process is available.

The abstracts will be selected by the scientific organizers, preference being given to those thematically related to one of the sessions of the program.

The accepted abstracts will be printed and distributed to the participants of the congress together with the documents of the meeting.

The authors will receive notification about acceptance and further instructions in November 2009.

Contact address for further information on the poster session:

Falk Foundation e.V.P.O. Box 652979041 Freiburg/GermanyTelephone: +49 (0) 761 / 15 14 - 0Telefax: +49 (0) 761 / 15 14 - 359Web address for submitting poster abstracts:http://www.falkfoundation.com/poster

The first author of an accepted poster will receive a travel grant of € 200.-

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List of Speakers, Moderators and Scientific Organizers

Prof. Dr. David H. AdamsQueen Elizabeth HospitalInstitute of Clinical SciencesLiver Research LaboratoriesBirmingham B15 2THGreat Britaind.h.adams@bham.ac.uk

Prof. Dr. A. AlbillosUniversidad de AlcaláHospital Universitario Ramón y CajalServicio de GastroenterologíaCarretera de Colmenar28034 MadridSpainaalbillosm@meditex.es

Prof. Dr. Ulrich BeuersUniversiteit van AmsterdamAcademisch Medisch CentrumDepartment of Gastroenterology& Hepatology, B1-244.2Meibergdreef 91105 AZ AmsterdamNetherlandsu.h.beuers@amc.uva.nl

Prof. Dr. Alexander L. GerbesInnere Medizin IIKlinikum der UniversitätMünchen - GroßhadernMarchioninistr. 1581377 MunichGermanygerbes@med.uni-muenchen.de

Prof. Dr. Dieter HäussingerGastroenterologie/HepatologieUniversitätsklinikum DüsseldorfMoorenstr. 540225 DüsseldorfGermanyhaeussin@uni-duesseldorf.de

PD Dr. Claus HellerbrandKlinik für Innere Medizin IKlinikum derUniversität Regensburg93042 RegensburgGermanyclaus.hellerbrand@klinik.uni-regensburg.de

Prof. Dr. Peter L.M. JansenUniversiteit van AmsterdamAcademisch Medisch CentrumDepartment of Gastroenterologyand HepatologyMeibergdreef 91105 AZ AmsterdamNetherlandsp.l.jansen@amc.uva.nl

Prof. Dr. Peter KernInfektiologieInnere Medizin IIIUniversitätsklinikum UlmRobert-Koch-Straße 889081 UlmGermanypeter.kern@uniklinik-ulm.de

Prof. Dr. Percy A. KnolleMolekulare Medizin undExperimentelle ImmunologieUniversitätsklinikum BonnSigmund-Freud-Str. 2553127 BonnGermanypercy.knolle@ukb.uni-bonn.de

Prof. Dr. Gerd A. Kullak-UblickUniversitätsspital ZürichDept. für Innere MedizinKlin. Pharmakologie/ToxikologieRämistrasse 1008091 ZurichSwitzerlandgerd.kullak@usz.ch

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Prof. Dr. Frank LammertKlinik für Innere Medizin IIUniversitätsklinikumdes SaarlandesKirrberger Str.66424 HomburgGermanyfrank.lammert@uks.eu

Andreas Limmer, Ph.D.Institut für Molekulare MedizinUniversitätsklinikum BonnSigmund-Freud-Str. 2553127 BonnGermanyandreas.limmer@ukb.uni-bonn.de

Dr. Antonio MoschettaUniversità di BariConsorzio Mario Negri SudVia Nazionale 8/A66030 Sta. Maria Imbaro (Chieti)Italymoschetta@negrisud.it

Prof. Martina Muckenthaler, Ph.D.Zentrum für Kinder- und JugendmedizinUniversität HeidelbergIm Neuenheimer Feld 15369120 HeidelbergGermanyMartina.muckenthaler@ med.uni-heidelberg.de

Prof. Dr. med. J. NattermannMedizinische Klinik IUniversitätsklinikum BonnSigmund-Freud-Str. 2553127 BonnGermanyjacob.nattermann@ukb.uni-bonn.de

Prof. Dr. Gustav PaumgartnerKlinikum der UniversitätMünchen - GroßhadernMarchioninistr. 1581377 MunichGermanygustav.paumgartner@med.uni-muenchen.de

Radhakrishna Rao, Ph.D.Professor of PhysiologyUniversity of TennesseeCollege of MedicineDepartment of Physiology894 Union AvenueMemphis, TN 38163USArrao2@utmem.edu

Prof. Dr. Tilman SauerbruchMedizinische Klinik IUniversitätsklinikum BonnSigmund-Freud-Str. 2553127 BonnGermanytilman.sauerbruch@ukb.uni-bonn.de

Prof. Kristina Schoonjans Ph.D.École polytechnique fédérale de LausanneForum EPFLCase Postale 103CH-1015 LausanneSchweizkristina.schoonjans@epfl.ch

Prof. Dr. Matthias SchwabDr. M.-Fischer-Bosch-Institutfür Klinische PharmakologieAuerbachstr. 11270376 StuttgartGermanymatthias.schwab@ikp-stuttgart.de

PD Dr. Britta SiegmundGastroenterologieCharité UniversitätsmedizinCampus Benjamin Franklin (CBF)Hindenburgdamm 3012203 BerlinGermanybritta.siegmund@charite.de

Prof.Dr.Dr.h.c.mult. Manfred V. SingerII. Medizin. KlinikUniversitätsmedizin MannheimTheodor-Kutzer-Ufer 1-368167 MannheimGermanymanfred.v.singer@med.ma.uni-heidelberg.de

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Prof. Dr. Ulrich SpenglerMedizinische Klinik IUniversitätsklinikum BonnSigmund-Freud-Str. 2553127 BonnGermanyulrich.spengler@ukb.uni-bonn.de

Prof. Dr. Wolfgang StremmelInnere Medizin IVUniversitätsklinikum HeidelbergIm Neuenheimer Feld 41069120 HeidelbergGermanywolfgang_stremmel@med.uni-heidelberg.de

A. W. Thomson, Ph.D.Professor of Surgery University of PittsburghSchool of Medicine200 Lothrop Street, W1540 BSTPittsburgh, PA 15261USAthomsonaw@upmc.edu

Prof. Dr. Herbert TilgBezirkskrankenhausHall i.T.Interne Abt.Milserstr. 106060 Hall / TirolAustriaherbert.tilg@i-med.ac.at

Prof. Dr. Christian TrautweinMedizinische Klinik IIIUniversitätsklinikum AachenPauwelsstr. 3052074 AachenGermanyctrautwein@ukaachen.de

PD Dr. Reiner WiestKlinik für Innere Medizin IKlinikum derUniversität Regensburg93042 RegensburgGermanyreiner.wiest@klinik.uni-regensburg.de

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General InformationPrior to the opening of the congress in Bonn

Falk Foundation e. V. Telephone: +49 (0) 761 / 15 14 - 0Congress Division Telefax: +49 (0) 761 / 15 14 - 359Leinenweberstr. 5 E-mail: symposia@falkfoundation.deP.O. Box 652979041 Freiburg/Br. (Germany)

Congress OfficeDuring the Falk Workshop

CAESARCenter of Advanced European Telephone: +49 (0) 228 / 965 68 639Studies and Research Telefax: +49 (0) 228 / 965 64 49Ludwig-Erhard-Allee 253175 BonnGermany

Opening Hours:Thursday, January 28, 2010 9.00 – 18.30 hFriday, January 29, 2010 8.00 – 12.00 h

Congress FeesThe participation at the Falk Workshop is free of charge, however registration is mandatory.

Refreshments during coffee breaks on January 28 and 29, lunches on January 28 and 29, 2010, the dinner on January 28, 2010 and a copy of the abstract volume of the Workshop are also free of charge.

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RegistrationCongress registrations must reach the Falk Foundation e.V. by December 31, 2009 at the latest.

After receipt of registration form, each participant will be provided with confirmation of his registration. On presentation of this confirmation at the Congress Office in Bonn participants will receive the congress folder containing name badges, admission tickets and the abstract volume.

All participants will receive a written confirmation of attendance and CME credits at the end of the meeting.

Admission to Scientific EventsFor admission to scientific events your name badge should be clearly visible.

Hotel AccommodationHotel reservations can be made throughTourismus & Congress GmbH BonnAdenauerallee 131 Telephone: +49 (0)228 / 91041-7855113 Bonn Telefax: +49 (0)228 / 91041-77Germany www.bonn-region.de

AirportInternational Airport Cologne/Bonn

The 26th Annual Meeting of the German AssociationFor the Study of the Liver will take place immediatelyFollowing the Falk Workshop (January 29 and 30, 2010).

Directions to caesarArrival by plane Taxi-transfer (30 minutes) which costs about EUR 30. Or bus line heading for Bonn, get off at Hauptbahnhof (central station), take bus line 610 or line 611, get off at the bus stop Kennedyallee. More information at www.airport-cgn.de .

Arrival by trainBy bus, you will get to caesar from the central station in about 20 minutes, taking the line 610 or line 611, get off at the bus stop Kennedyallee. More information at www.db.de .

Arrival by carMotorway 59 / 562 towards Bonn-Bad Godesberg, Exit Rheinaue, turn left into Ludwig-Erhard-Allee. Motorway 565 towards Koblenz, Exit Bonn-Poppelsdorf, via Reuterstrasse into Willy-Brandt-Allee/Friedrich-Ebert-Allee until crossing Hochkreuzallee where you turn left into Kennedyallee and carry straight on until crossing Ludwig-Erhard-Allee/Kennedyallee.

caesar

General Information:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DivisionTelephone: +49 (0) 761/15 14-0Telefax: +49 (0) 761/15 14-359E-mail: symposia@falkfoundation.dewww.falkfoundation.org

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