the enhancement of aluminum surface area by polymers template assistance
TRANSCRIPT
THE ENHANCEMENT OF ALUMINUM SURFACE AREA BY POLYMERS TEMPLATE ASSISTANCE
Prof. OtañoRISE Spring 2015Sara DiazPatricia RodriguezCamille RuizJustin Cotto
SIGNIFICANCE
Cancer therapy and bio imaging enhancement:Theranostic probesAuNP’s are biocompatibleHave vivid optical properties, and the flexibility to have different molecules and materials attached to their shellScattering: AuNP’s become visible to imaging processesAbsorption: Phototermal ablation Minimal damage to body cellsGold nanoshells are shuttled into tumors by phagocytosisA macrophage is formed
Alternative: Placing drugs inside nanoparticle and using it as a
vehicle Accomplished by coating outside of a nanoparticle
with iron oxideOnce the tumor area is coated with drug filled nanoparticles, they are activated
(Loo 2005)
NANOSHELLS UTILITY THERAPY
TECHNIQUES UTILIZED
Electrospinning Cellulose Acetate Poly(vinyl alcohol) –
Poly(acrylic acid) Regenerated Cellulose
Sputtering Deposition
ELECTROSPINNING
(Ning et. al. 2013)
SPUTTERING UTILITIES AND ADVANTAGES
Utility: Semiconductor industries Optical applications: glasses and telescopes Thin film transistors Low emissivity coatings on glass Fabrication of CD’s and DVD’s Efficient Photovoltaic solar cells
Advantages: Materials with very high melting points are easily
sputtered. Sputtered films typically have stronger adhesion on the
substrate Target contains large amount of material and is
maintenance free Sputtering sources contain no hot parts and are compatible
with reactive gases Size and relative thickness of the nanoshell can be
controlled by changing reaction time and plating concentration
PROBLEM
Which polymer is easier to detach from the deposited Aluminum, in order to acquire an Aluminum nano-shell?
HypothesisCellulose acetate detaches easily. Poly(vinyl alcohol) –Poly(acrylic acid) will only detach when soaked in water.Regenerated cellulose will not detach.
METHODOLOGY
SPUTTERING DEPOSITION
METHODOLOGY
DETAILED METHODOLOGY
METHODOLOGY
METHODOLOGY
METHODOLOGY
Deionized water
Deionized water + Ethanol
RESULTS
✓Obtained:✓Deposition of Al on fibers’ surface
✓Technical Issues
CONCLUSION
✓Hypothesis was unable to be proven
✓Future projects:✓Evaluation of fibers through electron
microscope✓Characterization of fiber morphology✓Comparison of optimal templates
CITED LITERATURE
Loo C, Lowery A, Halas N, West J, Dezek R. 2005. Immunotargeted Nanoshells for Integrated Cancer Imaging and Therapy. Nano Lett. [Internet; cited May 14]. Doi: 10.1021/nl050127s. Recovered at: http://faculty.washington.edu/markeh/MSE599/Loo_Nanolett_2005.pdf
Ning Z, Xiongbiao C. 2013. Biofabrication of Tissue Scaffolds in book entitled. Advances in Biomaterials Science and Biomedical Applications. Recovered at: http://ppl.ippt.gov.pl/18-few-words-about/17-electrospinning
ACKNOWLEDGMENTS
RISE PROGRAM Dr. Eneida Diaz Dr. Elena Gonzalez Mr. Giovanni Cruz
Professor Ota-o and his students: Xavier Ortiz Normarieli Passalacqua Alejandra De Jesus
THE ENHANCEMENT OF ALUMINUM SURFACE AREA BY POLYMERS TEMPLATE ASSISTANCE
Prof. OtañoRISE Spring 2015Sara DiazPatricia RodriguezCamille RuizJustin Cotto