the decade 1989-1998in spanish psyehology: an analysis of ... · the decade 1989-1998in spanish...
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The Spanisñ .iournal of Psycñology2001, Vol. 4, No. 2,219-236
Copyriglfl 2001 by TI.e Spanish¡comal of Psychology1138-7416
The Decade1989-1998in SpanishPsyehology:An Analysisof Researehin Psychobiology
Pilar Herreros de TejadaandCarmenMuñoz TedóComplutenseUniversity of Madrid
In Ibis papen Wc presení aB analysisof ¡he researchpublished during Ihe 1989-1998decade by renured Spanish faculíy mnembers from the area of psychobiology.Databasesearch and direcícorrespondencewíth the 110 faculty members rendered a Iist of 904psychobiologicalpapers.Classificationandanalysisof ihesepaperslcd Lo 1 lic definitionof at least70 differentresearchírends.Topics aregroupedinto severalspecificresearcharcas:Learning audMemory; DevelopmentandNeural Plasticity;Emotion andStress;Ethology; Neuropsychology;SensoryProcessing;and Psycbopharmacology.Theinternationaldisseminaíionof Ihis research,publishedin joumalsof high impactindex,and¡he increasingnumberof papersaretwo noteworthyfeatures.
En esteestudiose analizala investigaciónpublicadaen la década1989-1998 por losprofesoresnumerariosespañolesdel áreade la psicobiologia.La búsquedaen lasbases
de datosy correspondencia directa con los 110 profesoresdio comoresultadounalistade 904 artículospublicadosde psicobiología.La clasificacióny análisisde estosartículosllevó a la definición deal menos70 lineasde investigacióndiferentes.Se agrupanlostemasenvariasáreasde investigación:aprendizajey memoria;desarrolloy plasticidadneuronal;emocióny estrés;etología; neuropsicologí&;procesamientosensorial:ypsicofarmacologia.La proyeccióninternacionalde estainvestigación,publicadaenrevistasde alto indice de impacto, y el número creciente de artículos son doscaracterísticasimportantes.
Correspondenceconcerningthis arúcleshouldbeaddressed¡o Dr. Pilar Herrerosde Tejada,Departamentode Psicobiología,Facultadde Psicología.Canipusde Somosaguas.28223- Madrid (Spain).E-mail: [email protected]
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220 HERREROSDF TEJADA AND MUÑOZ TEDÓ
In [bis paper, we at<empt <o offer an overview of <hereseareh carried out iii the area of psychobiologyby tenured
faculty mernbers (professors)from the Spanishuniversitiesiii whieh ihe Psychology licentiateis taught.Re methodernployed is described in detall elsewherein <his specialissue (seeFernández).Therefore,we shall only comrnentupon the specificaspecrsinvolved in [bis areaof knowledge.
On April 4, 1999, the “Listado del Consejo deUniversidades”(University Council List) of the tenuredPsychobiologypmfessorsreachedthe numberof 110 (distributedin 19 universities,seeFigure lA). This is considerablyIowerthan[he numberof professorsfrom orherareasincludedin thismonographicnumber,becauseexceptfor Methodology,almost
ah of thesearcashavetwice or threetimes this number.Onthe basisof this lisí, we carriedout a bibliographicsearchinthe international databases MEDLINE, PsycLlT,andERIC,aswell as in the nationaldatabasePSICODOC9S,in order[oobtain [he hist of publications by eachprofessor.
Almería
Castellón
Granada ¡
Jaén
La Coruna
La Laguna
Málaga
Oviedo 2
País Vasco
Salamanca
Sant. Campos.
Sevilla
UAG
<3AM
UCB
<3CM
UNEO
Valencia
A
El
7
a
6
5
a12
12
lo
¡ 9
16
Stage One — Making a List qfPublications
As describedby Fernández,iii this monographicissue,we wished Lo make a hisr of available pubhieationsfor
interestedreaders,taking into accountthat the goal is todescribe[he research[rendsof eaehauca.Therefore,popularworks, theoreticalreviewsof topics that cannotbe considered[he researchtrcnd proper, and publications for teaching,weíediscarded.The problemof Iocating Spanishsumarnesin nationaland internationaldatabasesis weIl known. In
addition,the databasesthat include mostof the works bypsychologistsaresocialsciences databases,from which <he
works by psychobiologistsareoften exciuded.For example,thedatabaseMEDLINE includedmostof the works byprofessorsustedas Psychobiologyprofessors,whereasFRIC
did not includepracticallyany.Sornearcas,suchas ethology,were not well representedin anyof thesedatabases.In orderto counteract[besepíoblems,we contactedaH the tenured
Almería
Castellón
Granada
Jaén
La Conjña
La Laguna
Málaga
Murcia
Oviedo
País Vasco
Salamanca
Sant. Campos.
Sevilla
UAS
UAM
UCA
UCM
UNrD
Valencia
Bfl
u
a
a
0 5 10No. of Professors
35 20 O 300 200 500 400 500No. of Professors 1 No. of Seats
Figure 1. Numberof Psychobiologyprofessorsin Spanishuniversitiesin April 1999.A.- Distributionof te numberof tenuredprofessorsby universitiesB.- In eachuniversity, [henurnberof professors(from Figure JA) is comparedwith <he numberof searsoifered<o students,whichcorresponds<o <he valuesof <he axis of abscissasaid is representedby black bars. For theComplutenseUniversity of Madrid aud<he AutonomausUniversi<yof Barcelona,<he valuesareover 600 seats.(Thedataaboutseatsin <he universitiesare<aken from <hearticle by 1. Fernández.)
600
RESEARCHIN PSYCHOBIOLOGY 221
university professors, and sent them our list of [heir
publica[ions. This was well received. Guided by rheirresponses,we were able to completea [o[al list of over900publications (74% in English). This number refersexc!usively to works that meetpublication requirementsandit is an indica[ion of the intense andfruitful researchactivityof Psychobiologyprofessors.Many of [hesearticlesaresignedby more [han one [eacherfrorn [he Psychobiologylist, so that if we add ttp thc publicationsincluded for eachprofessorindividually, the number is over 1,400 articles.
Wc identified 70 researchÉrends. Ihis number isapproxirnate,as ¡u somecases,it would have beenpossibleLo divide a researchtrend lino several rends, because, over[he decade,sorneresearchgroupshavediversified [heirpublications.Nevertheless,if [he objec of study wasin[ernally coherent,wedecidednot [o divide die research[rends,unless[hegroupcornponentssuggestedtheopposí[e.
Therefore,in this ftrst stage,we highlight [hefollowingfea[ures of the areaof Psychobiology:(a) a large numberof publica[ions by [he majorí[y of the professors;(b) amarkedinternationaldisseminationof the research[rends,because most of the works are publishedin Englishand, ingeneral, in journals of high irnpact mdcx; (c) a highconcordancebe[ween [he areasin which professorsteachand thosein which they canyoil their research.
StageTwo — Elaborating he ResearchTrendsandGrouping (bern into Spec~ficArcas
shown, aI[hough sorneprofessorsmay be counted twice,because the sarnepersonmay be working in more [hanonearea.Within eachof thesecategories,the information isorganizedas follows: (1) mi in[roductory paragraphwhichs[ates [he number of research[rendsincludedin [hesection,andsornerepresentativecharacteristiesof the specificarea;(2) a paragraphdescribing each researchtrend; (3) aparagraphwhich men[ions research[rendsdescribedinanotherspecifxcarea, but which could have beenincludedin [hecurrentarea.
A [wofoldcriterion wasemployed[o selectthe referencesfor eachresearchtrend. On [heone hand,we attemptedtopresent[he works of ihe greatestimpact aud, on [he other,in order [o aid readers,thoseworks that presenta morerelevantnotionof [he researchtrend. Given the large quan[i[yof publicationsby professorsin this area, a rnaximumnumber of two works perresearchtrendwerequoted. Thereare on!y [hree exceptions where moreworks were quo[edand [his is dueto the aforeirtentionedcases.Tha[ is, [hoseresearchtrends tha[ could have beensubdivided in[o more[rends, but werenot. On the otherhand,readersmay besurprisedto find referencespublishedaf[er 1998. Whenestablishing[he research<rends,only works publishedbe[ween 1989 and 1998 were considered, bu[ oncea trendwas established,subsequen[ works were consideredaspossiblereferencesproviding they met the goal of presentingand dissemina[ing [he work of <he treud.
The speciftc researchareasaredescribedbelow.
The secondstageof this s[udy consistedof elaboratingthe researchtrendsproper. For [bis purpose,we againcontacted[heprofessorswho workedin a researchtrend [oinvite them,if they so wished,to cooperatein [hedeseriptionof the rnost representativeaspectsof [heir work. In researchtrends with participationby several professors,we contac[edat least [wo of them. In a[ least80% of the research[rends,sorneof [heparticipan[s collaboratedin their descrip[ions.
A seriesof categories(see Table 1) corresponding<o[hoseusedin rnost of the joumalsof [his areawas usedas[he organiza[ion criteria for [he varjoesresearch[rends.Thesespecific researchareasand [he numberof research[rendsiden[ified in each areaare shown in Figure 2. Thenurnberof professorswho work in eachspeciftc areais also
Table 1Spec<ficResearchAran ¿¿sediii this Work
Learning and MemoryDevelopmentand Plasticityof <he Nervous SystemEmotion aud StressEthologyNeuropsychologySensoryProcessingPsychopharmacology
Psychopharmacolo9y 2
SensoryProcCEsSing
Neuropsychology
Ethology
Emodon and Stress
Developmenl of CNS
Learning andMemory
0 5 10No. of trende
15 20¡ No. of Professors
25
Figure 2. Numberof <rendsandprofessorsgroupedby specificresearch(1989-1998).flacA Herr: Number of researchtrends. Cray Bars: Numberofprofessorsin eachspecif¡c researcharea(Theprofessorsappear
in more [hanone specific area if they participa<e in <hecorrespondingresearchtrends.)
222 HERREROSDE TEJADA AND MUÑOZ TEDÓ
SpecifacResearchAteas
Learningand Mernory
In this area,we identified a [o[alof 8 researchtrends,2of which — [he ftrst and [he last— couldhavebeensubdivided.In this specific area, researchis being carried ou[ withanirnals.Most of [hetrendsuserats as experimental subjec[s,although sorneusebirds and ftsh. Various types of learningwere ernployed, such as avoidance, aversive and¡nteroceptiveleaming,spatial onentationoc intracranialselfstimula[ion. Within biology of learning and rnemoryprocesses,[he trends rangefrom molecularstudies to thegenerationof modeisof rnemoryretrieval.
Re firsí research[rendcorrespondslo a groupof studiesof [hevisceral-brainsystemvia varioushorneosta[ic behaviorprocessessuchas nutrition (Ramos,Castillo, & Puerto, 1989)andhydro-mineralregulation(Morales,Cubero, & Puerto,1989), or acquisiúonprocessessuch asinteroceptiveleaming(Amedo, Gallo,AgUero, Molina, & Puerto,1993; Mediavilla,Molina, & Puerto, 1998). Within this <rend, two learningmodalities have been anatomically and behaviorallydissociated:On <he one hand,concurren[ aversiveleaming(instrumental),which involvesthe vagal axis, Ihe medialparabrachialnucleus,and cerebeilumcircuits (Agúero,Galio,Arnedo, Molina, & Puer[o, 1996) and, on [he other,sequentialaversivelearning(which is relational),mediatedby [he areapostremaand <he lateral parabrachialnucleus(Agúcro, Arnedo, Gallo, & Puerto, 1993). Re final goalsof [his groupof researchersare [o characterize func[ionally[he behavioral dichotomy belween [hese two types ofaversive learning, and to establishte anatomical circuitsinvolved hoth in learning and in memorymodalities.
The interestin loca[ing <he basic associa[ive brain sitefor taste-aversionIearning has lcd to [he applicationofreversiblebrain inactivation by in[racerebral injections oftetrodotoxin(Gallo, Márquez,Balles[eros, & Maldonado,1999). The data showing tha[ he pos[rial func<ionalinactiva[ion of the parabrachialarea disrup[s mo[ion-sickness-induced [asteaversionreveals an associa[ive role for Ihearea, independen[ of the sensoryfunctions. A rela[edapproach,using [aste-aversionlearning as the learningprocedure,concernsthe s[udy of the neural basisof complexlearningphenomenathat may requirein[eractions arnongindependen[ brain sys[ems. It has been shown [batconditionedblocking, bu[ no[ latent inhibition of [aste-aversionJearning,requiresan mIad hippocampus,and íha<the blocking effect may be reestablishedin hippocampal-lesionedrats by [ransplan[sof fetal brain tissue(Gallo,Valouskova,& Cándido, 1997).
A third researchtrend hass[udied, in day-oldchicks,therole of various cerebralarcasin passiveavoidancelearning,for the firs[ ime implica[ing [he hippocarnpusarnong theregionstitar mediaretitis leaming.It ñasalso heenestablished[hat funetionalla[eraliza[ion, manifes[ed in the medial and
intermedíatehypers[riate, is rela[ed lo asymmetryin titevisualprojection pa[hways. The role of nitric oxide and[hegrow[h factor of fibroblas[s in explora[ory locomotorbehaviorand novel situations,which might interfere withlearningprocesses(Sandi,Patterson,& Rose, 1993), wasalso síudied, in rats.
Neural plasticity in learning is also addressedbycompara[xve studyof the neuralbasisof leamingandmemoiy,in vertebrates,usingbehavioral,lesion,electrophysiological,aud neuroanatomicaltechniques(Salas,Rodríguez,Vargas,Durán, & Torres, 1996). Titese autitors also study [heteetoreticularand telencephalicsystemsthaI participateinthegenera[ion and control of spatial orien[ation movementsin veríebrates(Salas,Herrero,Rodríguez,& Torres, 1997).
Anotherresearchtrendon spatial orien[a[ion behaviorexamines[he slruc[ures involved, suchas Ihe hippocampalforma[ion, anterior thalarnus,and mammillary bodies, inrats, analyzingIhenumberof neurons,glial celís (especiallyIhe astroglial celis), oxidative metabolismand proteinsynthesis. The au[hors havedescribedthe consolida[ion ofspa[ial orientation behavior earlier in male rals than infemales,and [he possibili[y of modifying it by hormonalmanipulation(Cimadevillael al., 1999). This behaviorhasbeenassociatedwith the maturity and neuralstabiliza[ionof severallimbie siruclures.Metabolismwithin Ibis Papezcircuil [hroughout poslna[al developmen[ and aging has alsobeendifferentia[ed (González-González,Díaz, Vallejo, &Arias, 1996).
The last Ibreeresearcbtrends presentediii titis sectionare focusedon [he study of memory consolidationandretrieval processes. Researchersare carryingout experimentaldesignsalmedfundamen[ally al Ihe role of the amygdalaand[hehippocampusin tite memoryof emotionalprocessesandin the processof memoryconsolidationof discreteeven[s,those[ha[ only occur once in time and space(Peinado-Manzado,1994; Peinado-Manzado& Pozo-García,1996).
The study of the role of stressand glucocorticoidsinthe cerebralmechanismsinvolved in leamingand memoryprocesseshas revealedthat the releaseof glucocorticoidsduring learning facilita[es Ihe processesof long-terminformation transferThefacili[ating effectsof glucocorticoidsin memory processeshavealso beenstudied, and [heinvolvemeníof [heneuralcellularadhesionmolecules(Sandi,Loscertales,& Guaza, 1997; Sandi & Rose, 1994) wasobserved.
A group of researchershas establishedexperimentalmodelsof amnesiain rats and deveiopedmnodeisof memoryretrieval and facilitation in complex learning (Guillazo-Blanch, Vale-Martínez,Martí-Nicolovius,Coll-Andreu, &Morgado-Bemal,1999;Torras-García,Portelí-Cortés,Costa-Miserachs,& Morgado~Bernal, 1997). The treatmentsdevelopedare capableof accelera[ing and po[enlia[ing Iheprocessof memory consolida[ion, causingthe subjec[s [hatlearnless to reacit <he samelevel as [hosetitar leam more.Memory facilitation by meansof intracranialelectricalself-
RESEARCHIN PSYCHOBIOLOGY 223
stimula[ion in oid rais was alsoobserved(Aldavert-Veraetal., 1997). Tite resul[s show that lesions or electricalstimulaíion of nuclei related <o cortical aud cognitiveactivationof <he brain (neuralarousalsystems),suchas [heparafascicular,tite thalamic reticular,Ihe tuberomammillary,[hepeduncle-pontineor <he basalmagnocellularnuclei, canfacilitate acquisitionor long-tennre<entionof leaming.Thissugges[s that te subcorticaland brain stem síructuresinvolved in [he differentareusalsystemsmight be eriticalfor <he formation and potentiationof memory(Tenas-Huerga,Coll-Andreu, Guillazo-Blanch, Martí-Nicolovius, &Morgado-Bernal,1998;Vale-Martínez,Guillazo-Blanch,Aldaver[-Vera, Segura-Torres,& Martí-Nicolovius, 1999).On the basisof [he hypothesisthat eachneuralarousalsystem contributes some specific quality (cogni[ive,physiolugical, ur molceular) tu cortical informatiunprucessing,[heauthors of titis research[rendattempt[odiscern<he specific role of [he different neuralarousalsystemsin memoryconsolidation.
In the aboye paragraphs,we have describedeightresearch[rendsin [itis specific areaof LearningandMemory.Although sume more trendscould also be includedhere,they were included in anotiter section. Thus, in IhePsychopharmacolugysec[ion, we includea trendthat s[udies[he effectsof psychoactivedrugson avoidancelearninginrata (Morales,Torres,Megías, Cándido,& Maldonado,1992). In [he sectionun Emotion, we also presen<a trendin which learning measurementsare conductedon hyper-and hypo-emu[ional rats (Fernández-Teruel,Escorihuela,Castellano,González,& Tubeña, 1997).
Developmentraid Plasticity of rite NervousSystem
In this ai-ea, uve researchtrendsstudy tite developmentof [he nervuussystemand of beitaviur in ra[s and hams[ers.Tite f¿rst threetrends,very interrelated,studyaspec[s ofsexualdifferentiationof [he vumeronasalsystem(VNS) inrats,by <he action of tite gonadalsteroidsand tite GABAneurotransmitter.The studiesemployeda morphologicalandendocrinological,as well as a behavioral,outlouk (sexuallydifferen[iated behaviurssuch as sexual and parentingbehavior).The utiter two trendsstudy, amongotheraspects,<he influence uf gestatingmotiteis’ malnutritionun [hedevelopmentof [henervoussystem.
The wurks of [hefirs[ researchtrend are focusedon [heeffectsof diitydrotestosteroneon <he processof sexualdifferentia[ion of <he nervoussystem(Collado et al., 1992;Valenciaet al., 1992).
The secoridresearchtrend is centeredon maternalbehaviur,examiningtite hypothesisof vumeronasalinhibitionon the neuralcontrol of this behaviur(Ceno, 1998).Titeeffeetsuf prenatalenvironmeuitalstressun <he differentiationof <he central nervoussys[ern (CNS) (in <he VNS) andon<he expressionof maternalbehaviorare alsostudied(Cerroet al., 1995).
Las[ly, [herole of tite VNS in sexualdimorphismin ratswas s[udied and [hemos[ signiftcan[ conclusionswere: (a)Sexualdifferentia[ion in [henervoussystemdoesno[ occurin isoJatedneurals[ructures; rather, it affectscornplexneuralcircui[s (suchas tite SVN); (b) masculinizationof females0V feminizatiunof malesat <he neurallevel is rela[ed causallytu [he inversion of maternalbehavior(ma[ernal care ofoffspring is inhibi[ed in [hefemalesand facilita<edin [hemales);and(e> in additiuntu sieruidhormones,otber faetursalso intervenein <he sexualdifferentiationprocessof thenervoussystemand of behavior; [his could be considereda multisignalingprocess(Segovia& Guillamón, 1993;Segoviae[ al., 1991, 1996, 1999).
Of tite remainingtwo researchtrends,oneexamines[heeffec[s of chronicprotein malnutrition and administra[ionuf curtisul in gestatingrata un tite developmen<of <henervoussys[em and behaviuruf <he pups(Vicen[e, RodríguezPérez,& Gómez-Jarabo,1991;RodríguezPérez,Vicente,& Gómez-Jarabo,1992).
Tite Jast researchtrend studies<he developmentof <hedupaminergic neurons and [heir influence in motorlateralizationin rats(Alfonso, Santana,& Rodríguez, 1993)as well as the asymmetricdisíribution of theseneuronsmn[henervoussystem.The influenceof ma[emal ingestion oftyrosine is assessed,with specialfocus un the role ofmelatonin,its syn[hesis in ral and hams[er pineal gland andlís function in titeir estrouscycle (Santanae[ al., 1994).
In [heLeamingand Memorysection,[wo researcittrendsalso related<o tite developmen[and plasticity of the nervoussystemare presentedin moredetail: une that focusesonneuralplastici[y in learning(Salas,Rodríguez,Vargas,Durán,& Torres,1996), audanu[her that s[udies [hedevelopmentof [he s[ructures involved in spa[ial orientationbehavior(Cimadeviliaet al., 1999).
EmotionandStress
Studiesof the emotionalprucessesare a goudexampleof [ite diversi[y of approachestha[ characterizeresearchinpsychobiology.Of [he 11 researchtrendspresentedin thissection,sornework with animais (rat or mouse),carryinguut neuruendocrine manipulations, pharmacologicaltreatments,or psychogeneticcharacterizaíions.Otiter worksfucus on emotionin humans,involving sensoryprocessingof emotional stimuli, emotional disorders such assehizopitreniaor obsessive-compulsivedisorders,or theinterrelationsuf biological aspectsandsocial context.
Star[ing with themust basic research[rends,in tite flrs[one, a behavioraland neurochemicalcharacterizationwascan-lcdout in Rumanhigh-avuidanee(RHA: hypuemotiunal)and Rornanlow-avoidance(RLA: ityperemotional)rat strains(Fernández-Teruel,Escorihuela,Castellano,González,&Tubeña,1997),which havebeenpsychogeneticallyselec[edbr speedor incapacity(respec[ively) [o acquire two-wayactiveavoidancein tite shuttlebox,since [he late 60s. As a
224 HERREROSDE TEJADA AND MUÑOZ TEDÓ
consequenceof titis selection, [heRLA rats (cumparedwith[he REJA) presen[ moreanxiety aud s[ress responsesinVarious experimentalsitutilions, as well as a lower centralGABAergic function, lower mesolymbicdopaminergicfunction and higherculinergichippucampalfunetion.Theshort- and Jong-tcmieffcctsof infantile/juvenilestimulationproceduresin both s[rains of ra[s was also studied,observingthat, out of <he many variables examined, postnatalstimulaíion at<enuates/elimina<esIhese psychogcneíicdifferences(Escorihuela,Tobeña,& Fernández-Teruel,1995).
Tite following titree researchtrendsare classifledwititinpsychoendocrinology:In two of [hem,<he authorsare workingun experimentalrodent modeis,and in [he third, they ares[udying highcompeti[ion sportspeople.Thefirst irend studies<he biological basesof individual differcnces,especiallyemotion-relaiedaspects,manipulatingIbe thyroidaxis activityin rat (Darbra et al., 1995; Martí-Carbonelí,Sanz,Darbra,Garan,& Halada,1993). Theprincipal resultsare: (a) validationof a nonaggressivemethodof dysthyroidism induction; (b)behaviuralcharacterizationof dys[hyroidism as a funcílon of[heaffectedperiod; and (c) eharacterizationof the effectsofdys[hyroidism, ongina[ing in puberty, un [hemorphologyof[hepyramidalneuronsof [hehippocampus(areaCA3).
A secondresearchtrcnd studies[heeffects of varioustestosteruneby-producísun agonisticbehaviurin mice,and[he modulating role of various s[imulus condi[ions(aggression-inductionmudel,oppunenttype, etc.) (Martínez-Sanchís,Brain,Salvador,& Simón, 1996;Martínez-Sanchís,Salvador,Moya-Albiol, González-Bono,& Simón, 1998).In addition<o testosteroneprupionate,[heseau[hors havealso used decanuateof nandrolone,Stanozolol, and [heircombinations. These hormonal by-produc<s have becorneabuse-subs[ances in variouspupulationgroups,and impor[antpsycitological and behaviural effects havebeendescribed,including increasedaggressiveand viulen[ behavior,bo[hin men and women. On [he basis of <his information, ahypo[hesis of addictiun [o <hese substances,dcc [o [hereinforcingpropertiesof tes[os[crone, hasbeenproposed.
The [hird research[rendwithin [hepsychoendociinologyareaexamines[heeffectsof agonisticencountersun men’sand women’s [estusteroneandcortisol levels. Competitionsportshavebeenusedas a standardizedsi[ua[ion presen[ingsigniticantadvantagestu achieve<his goal.meresultshaveshownthe relevanceof experienceand uf situationalfactorsin tite hormonalresponsetu competitive stress.The rolesof physical effurt during competitionandof spor[smen’sphysical condi[ion in <he hormonal responsehavebeenspecifxed.Theseaspectshad no[ beenanalyzedin depth inpreviuusresearchal[hough [beyhad beenpoin[cd out (Suayet al., 1996).With regarátu Ibis, Ihere itave beensornepublicationsun [he hormonaland psychologicaleffec[s ofphysicaleffort and otherlaboratorystressors(Sanchís,Suay,Valverde, & Salvador, 1997).
Three research trends ínvestíga[e [he field ofpsychoneuroimmunology,usingrudentmodeis,andexamine
tite effec[s of stressun vartousparametersuf immunulogicactivi[y. The first trcnd also s[udies <he neuroendocrinemediatorsinvolved in [his relationship,using two [ypes ufstress:social stressand chronic mild stress (Azpiroz,Arregui, Fano, Garmendia,& Sánchez-Mar[ín, 1994;Azpíroz, cl al., 1999).
A secondtreud examineswhe[her different behavioralcapacities[o copewith stressfulsituatiunsmay be relatedlo tite functionalcapacityof tite irnrnwic systemnin mIs (iiistrainsselectedfor [heirlearningcapacityin activeavoidance[ests)(Sandi,Castanon,Vitiello, Neveu,& Morméde,1991).The au[hors found[hatdifferent functionality indexesof [heT lymphocy[es (proliferation, cytotoxicity of tite naturalkiller [NK] celís) are remarkablydifferentbetweenstrains.This indicatestha[ possibly sorneof <he geneiicfacrorsresponsiblebr cuping behaviorsare eitlier relatedlo facíorsinvolved in <he func[ionality of <he T lymphocytesor thatbutit factorswere gene[ically co-selected.Tite effectof titevarious stresshormonesun [heproliferationcapaci[y of <hespleenlymphocytesis also examinedin vitro.
The third researcl,[rend that addressestite s[ress-immunity relationshipwith experimentalmodelsin labora[oryanimals(ratsand miceof differents[rains) hasused surgicalstressmodeis(laparo[omies), chemicalstressmodels(s[ress-like drugs such as ampitetaminesand cucaine>,andpsychosocialstressmodels(nuisestresspatterns).The worksevaluate [he influence of tite s[ress pat[erns un varxousmeasurementparame[ers uf <he immunologic s[ate, bo[hquantitativeparametersand indicatorsuf <he functionalstate,(quan[if¡cation of T and B lymphucytes,cellularity of spleenand thymusgland,proliferateresponsetu mytugens,in vivoand in vitre phagocyticactivity, cytoíuxic activity —NKactivity and genera[iun of cyto[oxic T lymphocytes[CTL]—,<he retardeditypersensitivyresponse(DTH), and others),aud [hepossibility of reversing<he effec[s of stressun <heimmunesystemby pharmaculogicalmeans.Within <his[rend, tite effects of [he various modelsof stressun <hedevelopmentof different pathulogicalprocesses,such astumors and infectious diseases,havealso beenstudied(Freire-Garabalet al., 1996, ¡998).
There arefour more research[rendswithin theEmulionsection.They ah examineemotiunin humaus.In two oftitem, aggressivenessis síudiedfrom a biopsyeitosocialperspectiveandin tite othertwo, sorneaspectsof expressingand prucessingemutionsare examined.
In <he Communi[y uf Valencia, female vic[ims ufdomes[ic viulence,the consequencesof titis stressfulsi[uationun [heir rnen[al and physical heal[h, aud un <he hormonesystem,are being studied(Martínez & Botella, 1996).
Ja ancíherresearchlitad, <he modulatingrole of coníexíin <he manifestatiunof aggressivebchaviorsis examined.Tite auíhorsstudy tite iníerreiaíjonbetwecnaggresson-related psychulogical variables such as impulsivity,asser[iveness,dominance,and fear, un the une hand,and,un the o[her, biolugical variables suchas hormonallevels,
RESEARCH IN PSYCHOBIOLOGY 225
sexual dimurphism,anddevelopmentalpsychubiologicalcharacteristics.The pussiblepredicting value of specificvariables is addrcssedin [heanalysisof <his mul[idirectiunalin[errelationship, as well as possiblemodulatingvariablesthat might explain [heobservedvariability (Ramírez,1993,1998).
Brain act¡vity associa[edwi[h processingof emotiunalvisual stimuli is s[udied using electrophysiulogicalmeasuremcnts(Carretié, Iglesias,& García, 1997).Theau[hurs describehow ac[ivity pruducedbetween200 and300 rus is mainly assuciatedwith [he valence(pusitive-negative)of stimulation (Carretié, Iglesias,& Bardo, 1998)and how subsequentbrain ac[ivi[y is relatedtu <he activatingor relaxingcunsequencesof thestimulation.They havealsoobservedtitat responsetu negativestimuli activatestite fasrerdorsalvisual pathway,and [hatpositivestímuli activa[e titeventral visual pathway,whicit processesmore slowly butmorepreciscly.Thesedatacoincidewith <he resulís ufbehavioral studiesin which shor[cr reactiuntimes [o negativestimuli havebeenobserved.
In addition tu processingof visual emo[ional s[imuli,facial expressiunand recugnitionof emo[iuns iii ínfan[s hasalso beenstudied.An excitangeuf smilesin the motiter-child rela[iunship, visual discrimina[ion, and recognitionofexpressiunsof fear, anger,and surpriseitave beenobserved(Carretié& Iglesias, 1995; Serrano,Iglesias, & Lueches,1992).
In <he Developmentaud Plasticity of tite nervuussys[emsection,we mentioneda research[rend titat examines[heeffects of prenatal s[ress on [he differentiation uf <hevomerunasalsys[em (Cerro et al., 1995) anéin [heLeamingand Memory section, [he influence of stressun [heseprocesseswas described(Sandi et al., 1997).
Erhology
Among [hepsychubiologistsuf [heSpanishuniversi[ics,[itere is a group of professorswho are specializedinethology. Tite researchconductedby [heseprofessorsitasproducedfive research[rends,four of witich havestudiedbasicallyprima[es, both in cap[ivity andin naturalcunditions,and a fifth researchtrendstudiesbeitavior pa[terns in socialfish.
One rcsearchtrend is studying [he capaci[y uf self-awarenessin nunhumanprimates,murespecifically, incaptivegorillas audorangutaus.Researchersare trying tuverify whether<heseprimatesare capableof recognizing<heir uwn mirror-image, evaluating <heir spontaneuusbehaviorsand administering[heGallup test([he marktest).Titis study is especiallyimportan[ because,[o da[c, self-recugni[ion itas beendemunstratedin chimpanzeesaudbunobus,but [hewurks carrieduu[ by other researchgroupswith gorillas revealcun[roversial resul[s and tite da[a withorangutansproceedfrom very small samples(Coleil, Segana,& SabaterPi, 1995a,1995b).
A secondline focuses un [he way (1mw and why
ques[ions) gruup-living individuals initiate, man[ain, andterminate Meir social relationships,which invulve anintcrplay uf cuoperatiun,competition, ané affiliation.Observatiunaland longitudinal studieswerecarriedoutfocusing un [he fine-grainedanalysisof interactiunandcummunicationpatternsin -well-establishedsocialand socio-demugrapitic cuntexts. The majur aim has been [heuncuveringof behavioral and psychologicalprincipIesunderlying<he organiza[iun uf social systems(Colmenares,1991, 1992).
A [hird gruup of researchershascarried ou[ observa[ionsof repruductiveandparentingbehaviorin Calitricides, bu[hin naturalsituationsand in cap[ive animals.Titey itaveessentiallyaddressed[hestudyof environmentalfacturs thataffect uvulatury suppression;in Saguinusnedipus,cos[s ofcuoper-atiun are analyzed; in free-ranging ¡‘apio Ii.haniadryas,wurk is beingcarriedoutun [heir demugraphicdistribution and sociulugyin Eritrea (Gil-Burmann,Pelaez,& Sánchez,1998;Zinner & Pelaez,1999).
A fuur[h research[rendstudiesbehaviors,suchas nes[-building ur foud-gathering,of citimpanzees(Panpaniscus)in naturalcunditions(SabaterPi, Vea, & Serrallunga,1997;Vea & SabaterPi, 1998).
In tite fif[h research[rend, [hesocial urganiza[ion and<he mechanismsuf duminanceand formarion of hierarchiesin angelfish is being studied.Changesin behaviorin <hesesubjec[s, uccurringas a cunsequenceof <he experimentalmanipulatiunrequired[u submitthem tu individual tcsting,are also being ubserved(Gómez-Laplaza& Murgan. 1993).
Neuropsychology
The field uf neurupsycitology,with 21 researcit[rends,ineludestite largestnumberuf researehersamong titePsychuhiologyprofessursconsideredin [his study. Must uf[he [rendsare fucusedun neurupsychologicalfunctionsinhumansand titeir develupmentaland involutiunal aspects.Titeseprucessesare studiedfrum [heviewpoin[s uf clinicalas well as basicresearch.Wc havemaintainedtite classicaldivision betwcenbasicandclinical neuropsychology,firs[presen[ing tite six trendsthat studynormal populations,and<hen, [hefolluwing 12 [rends,which addresspatholugiesor<heir evaluatiun.Lastly, we includedtitree trends[ha[ufferanimal modelsof neuropsycholugicalpa[hologies, and afinal trend in which a cy[ugenetic s[udy in subjectswithTurner’s syndromeis presen[ed,although,<heseworks couldbe included in [he areaof basic research,becauseof <heirmetitod ur <he subjectsthey study.
Wc shall star[ with the descriptiunof <he six research[rendsusing normal popula[ions. In [hefirst trend, within [hefleld of witat we could calI developmentalneuropsychology,researchcrsare wurking un <he evaluationof neuroma[uradunaldevelopmentin healthy preschuulchilóren, with specialat[ent¡un tu childrenwith cerebraldysfunction.Fruit of titis
226 HERREROSDE TEJADA AND MUÑOZ TEDÓ
trendwas <he developmentuf [he“Cuestionariode MadurezNeuropsicológica Infan[il” (CUMANIN [Children’sNeuropsychulogicalMa[urity Ques[iunnaire]; Purtellano,Mateus,& Mar[ínez Arias, 2000), standardizedwi[h anextensiveSpanishsampleuf buysandgirís between3 and 6years of age. In addition <o <he heal[hy pupulatiun,neuropsycholugicalaltera[ions are studiedin uther infantilepopula[ions, suchas childrenwith diabetes,childrenwititgrowthhormunedeficit, or pretermchildrenwith luw budyweigh[ a[ birth (Portellano,Mateos,Valle, & Aizcun, 1997).
A secondresearch[rend has focusedun changesinphysiolugicalvariablessuchas hear[ ra[e, bluod pressure,and elec[rodermal activi[y in anxiety-pruvokingsituations,a[tention tasks,or in associa[iun wi[h [he mens[rual cycle.Therapeu[ic approacheshavealso beenexaminedtu favormodificatiun of physiolugicalvariablesobservedduringanxiety- ur stress-pruvukingsituations(Gómez Amor,Martínez-Selva,Román,& Zamora,1990; GómezAmor,MartínezSelva,Rumán,Zamora,& Sastre,1990).
Using [he event-relatedputential technique,a [hirdresearch[rendhass[udied sensoryperceptiveprocessesanda[ten[iunal andmemuryprocessesin healthysubjec[s. Thesampleincluded personsagedbetween20 and86 years,maleand female,of comparablesocioeconomicand cul[urallevels.The aim of [besestudieswas tu charac[erize [heage-relatedchangesobservedin titese subjectsira titeseprocesses(Amenedo& Díaz, 1998, 1999).
Otiter electrophysiulugicalstudiesbroachbidimensiunalvisuo-spa[ial informa[ion processingand [he cortical arcasinvolved.Working mcmory and semanticprucessingmay bereflec[ed in [he“recogni[iun po[ential,” acomponentassumed[o be crucial [o evaluatereadingproblems(Martín-Loeches,Gómez-Jarabo,& Rubia, 1994; Martín-Loeches,Valdés,Gómez-Jarabo,& Rubia, 1998).
In [he5Ch and Gb researcit trends, <he study of
asymme[ries in cogni[ive functions is addresscd.The 5Lbtrendfocusesun changesin neuropsychologicalperformanceand neurophysiolugicalactiviry (computerizedEEG)inducedby au[ogenous relaxatiunin lef[- and righ[-handed adul[s.ThephysiolugicaJand cogni[ive effec[s uf stradiol un brainasymme[ry in healthy women were also studied(León &Portellano,1999; Pur[ellano & Robles,1998).
The 61h researchtrend addressesbrain asymmetryinJinguisticand visual processing,iii order <o expJore literelativedegreeof brain asymmetry.Specifically, [heau[horsfocusedun [heparame[ers[batmodulateparticipationof [heright hemispherein languageand [he lateralizatiunof objectvisual recognition(Nieto, Hernández,González-Feria,&Barroso, 1990;Nieto, Santacruz,Hernández,Camacho-Rosales,& Barroso, 1999).
Within <he ficíd uf clinical neurupsychology,we haveidentified 12 researclxtrends [bat study human popula[ionswi[h variuusdisorders.The last une also s[udies prima[es. Of[hese12 [rends,[he tirsr <bree examinevariousconsequencesof brain lesions; [he following threc trends compare
paitologicalagingin with normal aging.Trends7, 8, and 9provide clinical evaluationins[ruments. Las[ly, trends 10, 11,ané12 are within <he areaof cronobiolugyand are<herefurepresentedtogether,although sumeof them are not strictlyclinical neurupsychulugy.
Within <he [rcndsstudying subjectswith brain lesions,in the firs[ une, researchersare examining [he long-termconsequencesuf brain lesionsin infancy. Their interes[ is tudeterminetite cerebralplasticity of [he imma[ure brain,consideringintra- and interhemisphericcerebralreorganiza[iunaf[er a brain lesion. The relationshipwas analyzedbe[weenmaturing factors (ageat trauma),brain lesionsdetectedbymagne[ic resonance(MR), and chronieneuropyschologicaldeficit. The autitors’ conclusiunsclearly differentia[e betwcencortical and subcorticalmacru-lesiuns.Ibis researchitas legaland clinical repercussionsand raisesdoubts abuu[ <hewidespreadconceptof genuinerecoveryfrom lesionsininfancy (Junqué& Vendrelí, 1997; Mataró& Junqué,1998).
A sccondresearch[rendstudiesfunetionalreorganizatiunafrer focal brain injuries. After sucb an injury, variousneurophysiolugicalphenumenaoccur [ha[ explain whyfunctiunal damageis more pronounced[han struc[uraldamage and why, in [he following months, partialspontaneousrecoveryof [hecugnitivefunctions is ubserved.Thesephenumenaare ischemicpenumbra,diascitisis,andtrarasneuraldegeneratiun,and raeuroimagingtechmiquesarecurrently bcing used [o investigatethem. Longitudinalstudies,employing SPECT,MR, andneuropsychulogicalmeasurements,are usedtu investigatehuw [heinjured brainreurganizesitsclf, af[er a first episodeof focal ínjury due[u ischemicinfarct or hemorrhage,with specialfucus unintraitemisphericcurtical-subeorticalreorganizationand alsointerhemisphericreorganization(Jurado,Bartumeus,&Junqué,1993;Pringatanoet al., 1998).
Anu[her gruup of researchershas analyzed,quan[itativelyand qualitatively, fumetiunal altera[ions related[u focalneurologicalpa[hology (in general,cerebral infarcts and[umurs)and <o diffuse neurulogicalpathology(dementia).This trend uffers a mc[hod <o exploreapraxiastaking intoaccoun[ he differencesor similari[ies of various volun[arymovemcnts(with and wi[hou[ meaning;tite useuf objects,traditional symbols),and also [hemudali[y in which gesturesareniade (verbal cummand,irnitation, real useuf ubjects).It also offers a qualitativesíudyof tite diflerení Éypesofresponsesmadeby subjects,which facilira[es analyzing<hemechanismsunderlyingapraxias(Mozaz, Martí, Carrera,&De La Puente,1990; Muzaz, Peña,Barraquer,Martí, &Goldstein,1993).
Comparisonuf normal aging and demen[ia is anutiterfucus point amungour universi[y neuropsychologis[s.Junquéandcolleaguesare wurkirag un a modal <hat combinesgeneticfactorsand s<ructuraland func[ional degeneration.Theyhypothesizcthat [hereare[hreeways uf normal brain agingthat apparentlysharepart of <he cerebralarad furactiunaldegenerationof Parkinson’sdisease,subcor<icalvascular
RESEARCEIN PSYCHOBIOLOGY 227
demen[ia, andAlzheimer’s disease.An attemp[ is made[orela[e gene[ic fac[ors wi[h [he way people age. Titedeterminationof Apo E andACE alleles in a extensivesampleof normal elderly individuals rnay be an indicationuf geneticcontribution tu <he subtypesof “normal” aging.Titus, [hepresenceof Apo E alleles4 may be related [omarkeddegeneratiunuf [hehippocampus(a form of memoryloss similar [uAlzheimer’s disease)andACE may be relatedtu vascularfactors [batproducesilent infarc[s in [hewhitematter (similar tu vascularsubcur[ical demeratia)(Pujol,Junqué,Vendrelí,Grau,& Capdevila,1992;Vendrelí,Pujol,Junqué,& Martí-Vilalta, 1995).
A secondresearch[rendfucusesun neuropsychologicaland differential diagrausisof [hevarioussub[ypes of dementia(Perea& Ladera, 1997a,1997b),evalua[ing [hedeteriorationof cognitiveprocesses.Ibeseau[hors areespeciallyinterestedIn [heexecurive frncrion and severalof its aspects(attentionaldirection, hierarchyrecugnition,expressingin[entions, e[c.).
And a [hird trend examines[heneurupsychologicaleffectsof neurodegenerativeprocesses.Speciflcally, it exploreshuwcugnitive processesare affec[ed in demyelinationpathulogy(multiple sclerosis),degenerativecerebellarpathology(hereditarycerebellarataxias),arad in normal aging (Barroso,Nieto, Olivares, Wullmann, & Hernández,2000; Nieto,Barroso,Olivares,Wullman, & Hernández,1996).
In <he ficíd of ncurupsychulugicalevaluation, a gruupof authurs has designedgeneralevaluation scalesandspecific syndromcscales(aphasia.amnesia,pusttraumaticsyndrome, etc.) fur prognosis in everyday clinicalpsychologyand in cugnitive rehabilitation(Perea,Ladera,Blanco,& Morales, 1999).
The misnzarchnegativity(MMN) cumponenthasbeenproposedas a clinical instrumeratfur physiulogicalevaluatiunof the auditory cugnitive functions, becauseit is obtainedindependentlyuf [hesubject’sattention.This compunentmaybe an elec[rophysiological indicatorof functiunal integri[yof [he brain mechanismsof at[entiun and sensurymernoryin Alzheimer’s disease, coma, ur neurodevelopmen[aldisorders(Grau,Escera,Yago, & Polo, 1998;Polo, Escera,Gual, & Grau, 1999).
Another trend is inves[igating, using event-relatedpotentials,[heneurofunctiuraalal[erations associatedwithsensoryand cognitivedeficits observedin mentally retardedchildrenuf variuus urganicandcultural-familial etiologies(Díaz & Zurrón, 1995;Zurrón & Díaz, 1995).
The following titree research[rendsbelong tu [hef¡eldof cronubiulogy.The f¡rs[ rend studiessleepdisurdersthatpresentexeessivedaytimesomnulenee(EDS).The authorsattempt [o determine[he pa[tern of neuropsychologicalaltera[ions- cognitive deficits and psychopathulogicaldisorders— specif¿callyassucia[ed with each of [hemainUDS disurders:sleepapneasyndrome(SAS), narculepsy-cataplexysyndrome,and psychiatrichypersumraia.Evaluatiunof long-[erm effectsuf con[inuous pusitiveairway pressure(CPAP)treatmentun vanoustypesof cognitive def¿citsand
[he level uf psychosocialadaptatiunuf SAS patientsisaddressed.The relative con[rabutiun uf etiolugical factors(apneaíndex,degreeof nocturnalitypoxemia,and anomaliesin [he architectureof sleep)tu the patitogenesisof [besecognitive deticits in SAS patients is alsoexamined(RamosPlatón& EspinarSierra, 1992).
Otherbiological rhythmsin additiun tu sleephavealsobeens[udied. The secondresearchtrend describesultradianrhythms in spuntaneousactivity uf awakehuman adults,usingan interval similar tu [he intcrREM sleep intervals(1 t/
2 huurs) (Grau e[ al., 1995).
In a [bird trend, researchershaves[udied circadianorganization,[emperature,anésleepin primates,in anat[empt tu establishanimal modelsof neurupsycitulogicalpa[hologies. The rela[ionship be[ween body [emperatureandactivi[y, bo[h in normal and in pathologicalsitua[ions, hasbeenexamined.The relatiunsitipbe[ween circadianrhythmsand ultradianand seasonalrhy[hms hasalso beenstudied.The fulluwing results are noted: (a) descriptionof [heevolution uf ternpera[ure during sleep; (b) verification ofsex differencesin thermolytic mechanisms;(e) studyufcircadian organization in an experimental model ofParkinson’sdisease(Almiralí et al., 1993; Almiralí, Nicolau,Garnundi,Ruselló, & Rial, 1997).
Wc will now describe<breercsearchtrends,[he inclusionof which in [hespecific Neuropsychologysectionmight bearguable,but which havebeenincludedhere tu avoidmuredivisions.The fxrst [rendpresentsan experimentalmodel ofhepatieencephalupa[hycausedby portacavalshuntthatpruvokescirrhosisand gives risc [u encephalopathyin [heCNS.This mudel hasalluwed[herescarchgruup tu de[ectsimilaraltera<ionstu <hosefuund in humans,in circulatingmegacariocytes,ira Alzheimer [ype-IIcelís,and in behavioralchanges,mainly biorhythms(Arias,Alsasua,Aller, Lorente,& Arias, 1993;Lópeze[ al., 1997).
A secondtrend includedin [hepsychugeneticfleid focusesun the rcsearchof new waystu s[udy Dowra’s syndrumefroma neurubiologicalapproach.The ftrs[ completebehavioralassessrnentof Ts65Dnmice (with partialtrisomy of [he 16-chromosune)hasbeencarriedout. This is currently tite bestmudel of human Duwn’s syndrorne.Sensury,motorandexploratorybeitaviur, anxie[y, spatial learning,and o[hercognitive abilities (sitort- and long-[erm rnemory, ‘workingmemuiy ) havebeen[ested,aswell as [heirafluenceuf certainexperiencesun subsequentperformaraceof specific tasks(Escorihuela,Fernández-Teruel,et al., 1995; Escorihuela,Valluna et al., 1998). In additiuntu [hedataubtainedaboutneuromorpholugicalaud neurochemicalaspectsof Ts65Dnmice, this characterizationhasrevealednew perspectivesinneurubiologicalresearchun Down’s syndrurnc.
In [he<bird researchtrend, a cytogeneticand behavioralstudy of individuals witit Turner’ssyndrumewas undertaken.The characteristicsof [he X-citrumosomeassociatedwi[h<his syndrumewere studied(FernándezMéndez,& Pásaro,1996;Pásaro,Fernández,& Méndez,1993).
228 HERREROSDE TEJADA AND MUÑOZ TEDÓ
Ira additiun <o tite 21 researchtrcnds describedin titeNeuropsychulogysection,anotiter interesting[rend,whichhasestablishedexperimentalmudelsof amnesiaandmemuryretrieval and facilitation in rats,is describedin <he Lcarningand Memory section.
SensoryProcessing
A small numberuf Psychubiologyprofessursinvestigateserasoryprocessing,focusing un <he auditory andvisualmodalities.Of [hefive researcittrendsdescribeditere, threeuf them study attention-relatcdsensuryprucessingusingelectrophysiologicalrecordings,and <he remainingtwu trendsexaminethe evaluatiun of sensoryprocessingwititin aspecies,usingcomparisunuf electruphysiolugicalrecordingsarad otherphysiologicaland behaviuraltechniques.
The first trend addressesbrain mechanisrnsin auditorycognitiun.The researchgruup hassiudiedcurasciousaudituryperception,auditory sensurymemury, and involuntaryauditory attention usingevent-relatedpotential recordingsin combinationwith uther techniques.By mearasuf <hemismatch negativity (MMN) that is generatedin <hesupratempuralcortexwhen a repetitiousstimulationcitanges(Escera,Alhu, Winkler, & N~atiinen, 1998), tite authorshaveestablished[he existence uf two differentiated brainmechanismstu captureinvoluntary attentiun.Rey itave alsoestablishedthat <he HI-histamine-receptormaybe invulvedin mismatch racgativity (Serra, Escera,Sánchez-Turet,SánchezSastre,& Grau, 1996).
The prucessingof task-irrelevantstimulation cen[ers [heiraterestof a secoradrescarchtrcnd. More specifically,<heSimun effect (i.e., spatial cumpatibility effectswhenstimuluslucation is irrclevant) (Valle-Inclán,1996) and the accessuryeffect (i.e., faster reactiuns when visual stimuli areaccompaniedby ara irrelevan[ auditury stimulatiun)(Hackley& Valle-Inclán, 1998) itave beeninvestigated.The researchun tite Simun effect cuncludestitat interfereraceduringresponseselectionis critical fur <he Simon effect tu appear,but it is dubiouswitether titis processshuuld becunsideredautumatic.Tite resultswith tite accessuryeffec[ iradicatethatit is pruducedbeforeresponseselectiunis over, which endsa long cuntruversyabuut <he locus of <he accessuryeffect.
In a <bird researchtrend, event-relatedpotentialsincombinalion wiíh localizaíion techniquesand frequencyanalysishavebeenrecordedtu study spatial visual attention.It hasbeenpointeduut [bat tite CI cumponeratis lucalizedin [hestriatecor[ex, ané[bat a[<en[iunal modulationbeginsin extrastriateareas;alpharitythm attenuatiunandbetarhythm incremen[ havealso beenobservedduring <hesetasks(Gómez,Clark, Fan, Luck, & Hillyard, 1994).Applying[he gap paradigmtu study motor attention,[he followingresultsarereported:(a) thc gap effect is rubustand it appearsira visualand auditory mudalities,both in manual andocularresponses;(b) unfocusedatientiun and preparatiuraformovementmay cuntribute<o <he gapeffect; (c) event-related
potentialssuggestprocessesboth uf sensurygap recurdingand uf preparatiunfor muvement(Gómez,Atienza,López-Mendoza,& Vázquez, <995). Theseautitors havealsodeterminedsume components of electruphysiulogicalrecurdingsassuciatedwitit sensuiy memory in differcnt statesuf arousal,and witit faceprocessirag,ambiguousfigures,etc. (Atienza, Cantero,& Gómez,1997).
Tite next two research[rendsfocus un the visual func[iunof a specics.Tite citaracterizatiunof tite visual func[ion ufa speciesis irrapurtantbecause,un <he une hand,it providesknuwledgeabuut itow visual prucessingis achievedandhow tite visual systcmbecameestablishedat a certairapointuf [he pitylugenetic scale.On the utiter harad, it offers amudel <u evaluatetite cffec<s of experimentalmanipulatiunsun a species,and <he disorders<bat affec< titat species.Twugruupsuf Sparaishpsychobiologistswork in titis area.
Ira invertebrates,une gruup studiesguided visual behaviorin <he artitrupudLycosa larentula (Araneae,Lycosidae),auditave establishedtite continuity betwcenmorpitological,pitysiolugical, arad behavioralaspectsof tite orieratatiuracapacityof titis spiderusirag pularizedligití (Kuvuur, Muñoz-Cuevas,& Ortega-Escuhar1993; Ortega-Escobar& Muñoz-Cuevas,1999).
In <he fif<it and last researchtrendof <lis section,<heauthursdevelopeda model tu evaluate<he visual function inrats arad mice, tite two mus< frequently used speciesInresearch.Ira <he study un visualacui<y, measuremeratsof [heuptical quality uf tite re<iraal image were cumparedwitit [hethreshuldsestimatedfrom cortical EPs, arad with beitaviuralmeasurements.In tite study on luminance,electrophysiolugicalthresholds(with recurdiragsuf electrure[inogram,event-rcla<edcortical po<entials(EP) and EPs ira tite superiorculliculus)and behaviuralandpupillary threshuldswereobtaincd.Thismudel may be very useful for early detectioraarad diagnosisuf visual funetiura alterations,as has beenrevealedira tites[udy uf albiraosubjects(HerrerosdeTejada,Green,& MuñozTedó, 1992; 1-len-erosdeTejada,Muñoz Tedó, & Costi, 1997).
In titis section,five researchtreradswere described.In<he Emotiun sectiun,a muredetaileddescriptioncan befuund uf araothertrend titat also addressessorneaspectsufsensory prucessing, specifically emutional stimulusproccssing,implying tite dorsaland ventralvisual pathwayswitb tite negativeor pusitivevalenceof tite sensorystimulus(Can-crié,Iglesias, & Bardo, 1998).
Psychophannacology
Tite greatestamuuntuf researchappearsira [his ficíd,along with Neurupsychulugy.Wc haveidentified 15 rescarcittrends,uf which many (cigití) fucus un [hestudyof abuse-drugs and addictivebeitaviur, which are topicsuf greatsocialimpact.Of <beseeight trends,uve study alcoholism.Theremairaing severa trerads study [he effects uf certainpsychuactivedrugs,buth in <he clinical ficid arad in <hedcvelupmen[ of animal mudeis.
RESEARCHIN PSYCHOBIOLOGY 229
Abuse-drugsform part uf a small numberof substances[batare chemicallyquite distinct from eachotiter, but titatare capableof aJtcringan individuals emutional andmutivational statedrastically.In [hef¡rst trend,<he controlof the neurubiologicalsubstratesinvulved in [beseprucessesis studiedin experimentalrudcnt mudels. Ira addition,pussiblepsycitopitarmaceuticals[rategics capableuf reversing<he action of drugsare being developed(Navarro, Rubio,& Rodríguezde Fonseca,1995; Rodríguezde Fonseca,Carrera,Navarro,Kuub, & Weiss,1997).
Tite secondtrend addressesthe role uf the dopaminergicsystemin tite generadorauf the rcinforcingeffectsuf abusesubstancesand of excitatoryamino acidsthat are possiblymvolvedira tite addictivemechanismof opiates.Locadora-prefereraceconditioning is usedtu study tite reinforcingproperdes(dependence)uf titesesystems,whereastu studytite aversiveproperties(abstinencesyndrome),aversivelocadoraconditiorairagis used.Theauthorsalso analyzetherole of tite nucícusaccumbensand [he prefrontal cortex,buth iii tite developmentuf dependenceand in titecunditiunedeffectsuf <he abstinencesyradromeof morpitine(Aguilar, Mari-Sanmillán,Morarat-Deusa,& Miñarro, 2000;Rodríguez-Arias,Miñarro, Aguilar, Pinaxo, & Simón, 1998).
The third treudexamiraestite reinfurcementmechanisms(cellular mechanismsarad systemsmecharaisms)uf upiatesarad cucaine.Sclf-administratiunuf abuse-drugs(morpitinearad cucaine)and titeir relation witit spuntaneuusmotoractivity and cardiovasculareffectswere investigatedin rats.Tite interaction mcchanismsuf opiate receptors,[iteirreinforcingeffect, and <he modificatiurasdue <o tite actiorauf corticutrupinwcre examined(Ambrosio, Sharpe,&Pilotte, 1997;Persico,Scitindler,Davis, Ambrosio, & Uhí,1998).
Studiesare undcrtakenun tite possiblerole of upiatepeptidesasmediatursof tite reinforcing actionof alcohol andtite consequentdevelupmentof preferencefur alcoholcorasumptiun(Sandi, Burrelí, & Guaza, 1990). Por [itispurpose,in titis fourth trerad,an experimentalparadigmof“preference’ witit mts was used,following a mudel uf “doublccituice” betweenwater andetitanol.The sessiunof forcedingestionof etitanul (cundi[ioning sessiora)was revealedtube crucial for tite dcvelopmentof ethanulpreference.Bynieans uf psychopitarmaculogicalappruximatiuns,<heinvolvement of tite opioidergicsystemsin <he develupmentof preferencefor alcohol consumptionwasdemonstrated.
The next four researchtrends also studyalcuholism. Ontite basisuf titeir uwn theory uf tite processuf dmg addiction,a group of researchershas developed standardizedexperimentalmudeisof alcohulism(~hich alluxv verifacatioraof levels of consumplion,tolerance,abstinencesyndromc,etc.) using unselectedalbino rats, witit whicit [he>’itave studiedvariuusaddiction-relatedassuciativelearningparadigms.Thisgruup has reporteda speciflc relationbetweenconsumptionof toxic dosesuf alcohol and the simple learning of aninstrumentalresponse.Titis hasallowed<bern tu contrast
various itypothcscsabout [heneuroanatomicalsubs[rate ufaddictiunsarad tite cholinergichypothcsisuf physiulogicaland molecularchanges.The first dose/respunsestudieswerecarriedout abuut tite effectsof nicutine and mecamilaminein septal areaandhippucampusun learningandtite inhibitionuf appctitiveresponses,ira chronic alcoitul-drirakingsubjects(Nadal, Prat, Pallarés,Hernández-Torres,& Ferré 1996;Pallarés,Nadal,Hernández-Turres,& Ferré,1997).
The enzymaticneuralmechanismsinducedby etitanuland tite beitavioral importanceuf <hesemecitanismsarebeing examinedby manipulatingcatalasewith inhibitorsarad inductursuf titis enzyme(Rotzir¿ger,Aragón,Rugan,Amir, & Amit, 1995; Sanchís-Segura,Miquel, Currea,&Aragón, 1999).Ibis hasallowedresearcherstu show thatsume effects of etitanul seemtu require tite uxidation ofetitanol tu acetaldehyde:catataseInhibitors block titeseeffectsdeperadingun the dose,whercasinductors enhancethcm.The lucalizationof titis metabulismin theCNS is beingstudied,becausecatalasedoesnot seem<o be homugcneuuslydistributed in tite brain. Tite behavioralconsequcracesofmanipulating<he levelsuf acctaldehydein <he braira are alsounderstudy, with pitarmacologicaltuols,usingsulphuratcdaminoacidsthat havebeenubservedtu bind acetaldehyde¡u vivo, arad iraitibiturs of tite brainenzymethat metabolizesacetaldehyde(ALDH).
Thc delimitatiora uf a neurocognitiveprofile of familyvulraerabilityis anotiteraspectof alcoholismunderstudyiraa researchtrend. Basedun studiesof geneticepidemiologyaudmodelsuf risk fur dcvelupingalcuholism,an extensivepsychophysiological(EPrecurdings)arad neuropsycitologicalbatterywas usedto identify possiblevulnerability markersin citildren from families with a high densityof alcuholisro,but who hadraot yct comniencedalcohol ingestion. Titereis evidenceof putentially useful cues that could be testedby mearasof follow-up studies(RodríguezHolguín, Corral,& Cadaveira,1998a,1998b).
Ira chronicalcoholicabstineratpatients,ncurofunctiunal
deteriorationhasbeenevaluatedwith the EP tcchnique.InIbis research,shurt-, medium-,and lorag-latencyvisual andauditory EPswere used,as well as endugenouscumpuraentssuch as N2, P3, andnegativeconuingentvariaban (NCV).Exceptfur NCV, tite testshaveprovedtu be highly sensitivefor assessing[he neurotoxiceffects uf alcohol (Cadaveira,Grau, Roso, & Sánchez-Turet,1991). Large individualdiffereraces were revealed in <he effects of chronicconsumptiuraof alcohol,evenamoragpersunsof similaragesaraddrinking histur>’. Five-monthand 1-yearfollow-ups ofabstineraceshowed unly partial reversibility of theabnurmalities(Cadaveira,Curomiraas,RodríguezHolguín,Sárachez-Turet,& Grau, 1994).
Wewill nuw describetite sevenremainingresearchtrends,alí of them focusingun variuus psychoactivedrugs.Ira <hefirst trend, studiesof scitizopitremicand obsessive-cumpulsivepatients, and of patients affected with attention-deficithyperactivity disorder (ADEJO) are being conducted,
230 HERREROSDETEJADA AND MUÑOZ TEDÓ
addressing[heeffectsuf psychoactivedrugs ira regionalbrainmecabolismarad ira cognitiun. Ibesewurks shuw structuralarad functiunal deficits [bat indicate an alteration of [heanatomie-furactionalraeurodevelupmentuf tite fronto-s[riatumsys[em. Ira schizuphreraia,frontal basalneurodevelopmen[alhypofunctíonwas detected;in ADIAD, a decreasedvolumeof [hefruratal bbc was identified,in additiun tu a larger-than-normal sizeof [heright caudatenucleus.Psychuactivedrugsthat affect <he dopaminergeticsystemproducechangesira [hebasal gangliaarad in the medial prefrontalcor[ex that aredetectableby meansof magraeticresunance.Neuruchemicalaraalysisira vivo, along wi[h tite araalysisof [herapeuticresponsearad cugnitive changes,ma>’ impruve clinicalpsychiatricpractice (Mataixet al., 1997; Verger, Junqué,García, Pardo,& Martí-Vilalta, 1996).
Ira <he secondtrcnd, ira additiun tu ara epidemiolugicalstudy in a mental itealth center,researchun psychopatholugicaldisurdcrs, such as panic arad aggressiun,and possiblepsycho[herapeuticaradpsychupharmaculugicaltreatmeratswascarrieduu[ (LópezAlonso & Gómez-Jarabo,2000).
Ira tite <bird trerad,animai modeisare used tu study<hedoparniracrgicsystcm(Navarro,Miñarro & Simón, 1993),CABA, and utherneurutransrnitterssuchas upiuids, nitruusoxide, arad ademosine(Fspert,Navarro,Salvador,& Simón,1993) ira aggressivebehavior.The role of tite CABA systemira Che reguladoraof utiter itehaviorsis also examined.
The effec[s of variouspsychoactivedrugs ura agunisticbehaviorin mice were studied,usirag a behaviorassessmeratprogram [u examine<he variatioras in several beitaviorcategoriesaradpatterns.Ira this fourth [rerad,<his techraiqucwas appliedtu <he studyuf represeratativesubstancesof [hemain groups of psychuactivedrugs: antidepressants,psychustirnulants,anxiolytics, arad upioids.The effect unagonistiebehavioruf sumestimuluscunditioras,such as [hetype uf oppunera<,repeatedfighting experierace,arad <hemodel uf inducedaggressiunwerealso araalyzcd(Martíraez,Salvador,& Simón, 1994;Moro, Salvador,& Simón, 1997).
Arauther group of researchers is carrying uutpharmaeulugicalstudiesabuut tite effect uf diazepam,buspirone,and chlurpromazirae,and utherpsychoactivedrugsun active avoidancelearraing (Morales,Torres,Megías,Cándido, & Maldonado,1992; Torres,Morales, Cándido,& Malduraado,1996).
Ira [lic sixth <rerad, sex differences ira <he effects ofraeurulepticdrugs un escape-avoidancebehaviorin mice arestudied.Tite acuteadministradoraof italoperidol, raclopride,cluzapine,arad SCtA 23390, impaired escape-avoidancebehavior,more ira malestharaira females,and tite subchrunicadministratiunof haloperidul had a similar effcct. Titisappearedtu be a reliable pitenomenon,becauseit wasobservedin buth kirads of administratiora,ira two muuses[rains, andwith severaldrugs arad doses.The observedresul[s were dosedependent.The sex differenccsira escape-avuidancedid not seemrelated <o sex differencesira <hewell-knuwn detcriuratingcffeetsuf <besedrugs un motor
activi[y. In addition, an analysisuf [besestudiesshowedthat diere were no sex differcncesin tite variability ofresponses,reirafurcing [he ideatha[ femalesubjectssitouldbe included ira [hese types uf studies (Parra, Arenas,Muralcón, Vinader-Caeruls,& Simón, 1999).
The identificatiura uf the endocannabinoidsystemas anew systcmuf sinap[ic communicatioraarad neuralsignalingwas a ver>’ impurtantneurobiulogicalevent ira <he niraeties.This systemis invulved in <he control of motor behaviorarad in variuusneuropsychiatricdisorders.Oneof <he teamsof psychubiolugistshas cerateredits wurk ura identifying thefunctional natureof <he principal endugeraouslipid of <heendocannabinoidsystemarad i[s behaviuralrelationship(Giuffrida et al., 1999),arad <he ftrst internationalmonographun <his systemhasbeenpublished(Rodríguezde Fonseca,del Arco, Martín-Calderón,Gurriti, & Navarro, 1998).
In [he Emotiora section,we describedan iraterestingpsychopharmaculugy-relatedtrerad, in which researchersareusirag testusteroneby-pruducts,hyputhesiziragaddiction<o[besesubstancesbecauseuf <he reinforcing propertiesoftestosterune(Martínez-Sanchíscf aJ., 1998).
Conclusions
Titis wurk is tite result of tite studyof researcitpublisitedby Psychubiolugyprofessursfrom 1989 tu 1998. Oralyterauredprofessorswerecorasidered,totalirag 110 professorsfrom 19 uraiversities.Tite total list of publicatiorasiracludes904 differerat articles. 1429 Psychobiolugyprufessorsco-sign <bese904 articles. The resultsof <beseiravestigatiurasare describedira whatWc havecalledresearchtrenás,wbich,ira <ura are groupedirato specificresearchareastu facilitatefollow-up arad preseratationof a panoramaof <he curatentof<he Psychobiobogypublicatioras.
Scientijic Productio¡z
Fur eachprufessur,the rate of scientificpruductioratakenirato accountis ara averageuf 13 quutatiuns.Perhaps<hisaverageis not ver>’ represeratativedue tu <he large iradividualvariation in tite numberof publications—from J <o 92quo[ations—among[he researchers.Similarly, it could becuncluded<bat <he witole tateof qautadorasfrom <he decadeis contaminated,because,taking irato account[he list ofprufessors(tite liniversity Coraracil List of April 7, 1999)who achieved tenure betweera 1979 (when <he firstpsycitubiologyprufessorachievedtenure)and 1999, sumeresearchers’publicatiorasdo nut correspuradtu 10 ycars ufwork with tenure, but ratiter tu sitorter iratervais.Wc alsopuiratuut that, in <bis decade,only 15% uf <he professurshavepublishedless <han 5 articles,arad <he prufessurswhomwe could not cun<actafter <he first le<terbelungtu [his 15%.Titerefure,<beselatterprofessorsma>’ havepublicatiunsnutreflectedira <bis article.
RESEARCHIN PSYCI-IOBIOLOGY 231
Essentially,whcn a prufessorjuiras [he University,bisor her researchingtrajector>’ is evaluated.Professurswhohaveworkedbeforetheir accesstu tenurein researcitcentershavehad moreopportunitiestu publish [hanhaveuntenuredteachers(teachershiredby <he IJniversity), who must teacitarad investigatesimultaneously.In Figure IB can be seen<he mismatchbetweera[hequantityuf students,whoseclassesare oftera taught by untenuredteachers,arad [he numberuftenuredprufessors.Wc must [herefureemphasizethat [heproportion uf publicatiorasper researcheris ver>’ high,especiallytakirag into accuunt tha[, ira most Sparaishuniversities,researchcrscan unJy spendpart uf their timeinvestigatingbecausethey must dedicateup tu 240 hoursper year tu preseratialclasses,obviuusly ira addi[ion tu <hetimespent ira personalizedattentiontu students.This prevents<bern frum working ira [helaburatoriesdurirag the instructionperiod; [beyalso usualí>’ haveuní>’ orac sabbaticalperiod ira[heir lives.
Lastí>’, wc must take into accuurat[bat PsychulogyFaculties (PsycholugyCenters)are oftera quite recen[ arad,[berefore,in [hetenyearscunsidered,new Study Piarashavebeendeveloped,with <he correspundingurganizationof <hecurricularcontentuf Psychubiulugy(compulsor>’ ira alíUniversities) arad, especialí>’, mounting [he researehlaburaturiesin [he facultiesand obtainirag<he necessaryfunds. Psychubiulogy laburaturies require high-techinstrumentatiura,which, in general,mearaslargeinves[mentsfor PsychulogyFaculties.
As a generaloverview uf <hesecommerats,ira Figure3can be seen<he total numberuf quotationsira [he 89-98decade,corresponding<o tite professorsfrom <he Jistempluyed(<he University Cuuncil Lis[ uf April 7, 1999),
separatedinto 3 gruups accordingtu <he dateswhen <he>’achievedtenure.The ftrst bar represcn[s [he 110 prufessursfrom tite list, who achieved[enurebetwecn1979 arad 1999;<he blackcircie corresponds<o [he 1429 quotatiorasduringthe 10 years.The secoradbar currespondstu <he group uf85 professurswho had teraureira 1994 (mid-point of thedecadeunderstudy); arad [he circie represents<he totalraumberof quutations(1015) by this gruup during titedecade.Tite [bird barrepresen[s [heprofessorswho airead>’had tenure(42) at <he bcginninguf theperiodunderstudy(1989) arad tite circle represen[s <he total number ofcorrespundingquuta[ions (578).As can be seenin <he dataof <his chan,out of <he professorsfrum the list, 38% alreadyhad teraurein 1989, another39% were tenuredduring <hefirst 5-year periud, arad [he remairairag 23% durirag [hesecorad5-yearperiod.
Spec~ficResearchArcas
With regardtu grouping [heresearch[rcndsirato specificresearcharcas,no doubt [here could havebecra moresectioras,or [hesec[iuns includedcuuld have beendividedinto subsections.Forexample,<he researchtrerads includedira Emotiora could be divided into specific subareas,suchas Psychucndocrinology,Psychoimmunulogy,etc. On [heo[her hand,[he bruadrangeuf publicatiurasof the samercsearchtrend wuuld alluw classifying them into more[hanune specific area. Becauseof [bis,we decided[batgrouping<he works into large arcas would help readerstu get apanuramicuverview of <he works. Ira Figure 2 canbe seen<he speciticaieasdescribed,tite numberof researchtrendsincluded ira eachuf them, arad the raumberof UniversityCouncii List prufessurswho participatedira <he studiesiraeacharea.
No. of quotations
Figure 3. Numberof Psychobiulugyprufessors,frum ¡he list
siudiedin <his work, accordingtu <hedateuf titeir access<u <enurebetween<he years 1989-1999.Rars 1 Left YAxis: Number uf professursaccurdingtu ¡he dateof<heiraccess¡o tenure.BlocA circies /Right YAxis: Total numberuf quota<ionsduring (he 89-98 decadeof <he groupuf correspondingprufessurs. Y Axis: Deadlinefur acetaslo tenure(set1cM).
1500InternationalDissemination
The languagesusedprefereratiallyin [he904 publicatiorastakeninto accoun[ are Englisit (74.7%)and Spanish(24.8%);
1000 ira <he remainiragarticles,less <han 1%, uther laraguageswithless dissemina[iun in uur scientitic se[tirag (Japaraese,German,Catalan,etc.) were used.The percentageof almost75%iradicates a high rate uf commuraicatiuraof resul[s, sinceEnglisb is currently <he languageuf [hescicntifaccommunity.Regardirag[hejournals ira which tite articleswere published,ira tite bibliugraphyselectedas referencesof [he research<rends,une can find a high percentageof internationaljournals,sumewith maximumpublicatiorarequirements.Irasume cases,<besepublicatiorascorrespondtu cuoperatiunwitit foreigra researcitgroups,arad ira others,tu works cardedout by oraly-Spanishgruups.Readersarereminded[bat[heneedtu deferadarad publish worksira internationaljournalsis an additional <oíl for researcitin our uraiversities,and <heuní>’ way tu avuid sciera[ific isulatiun arad tu acitieveinternationaldisseminaíiunuf <he resalísobtained.
No. of professors
120
100
1999 1994 1989
232 HERREROSDE TEJADA AND MUÑOZ TEDÓ
Lastí>’, it is nuteworthy [bat in [itis decade, <he
achicvemcn[s uf rcsearchin Psychobiology ira Sparaisituniversitieshaveimprovedgreatí>’, partially becauseof theincreaseira thepropurtion uf researchersarad, especially,
tite itigh impact uf thejournals ira which [he articlesarepublished.Although <he irnpactof <hesejournals is anothcriradicatiun uf tite pussible quality of the conten[ of <he
publications, ira [he evaluatiorauf <he researchcontributedby Psychobioiugyprofessursira <bis decade,without a duubt,tite conten[ is more importantthan tite amount,arad we have
tried tu emphasize<his aspectira <bis s[udy.Luoking at [he futureof researchira Psychubiulogy,wc
wish tu poin[ uut titat [he numberuf publicatiorasarad [henumberof high-impactpublicatiorashavebuth increasedira[he last yearsuf [his decade.In addition, almost ah <he
professurshavementioraed[bat [heir 1999publicatiorasand<heir prujec[s for [he year 2000 wereuf betterquality <hanthoseuf 1998, and <his can be consideredan iradicatioraofgrowth andimprovementira tite worksof tite raendecade.
Retetences
AgUero, A., Arraedo,M., Gallo, M., & Puerto,A. (1993). Lesionsof tite lateral Parabrachialnuclei disrupt aversionIearninginducedby electrical stimulationuf <he areaPostrenia.DramResearchful/edn, 30. 585-592.
Aguero,A., Gallo, M., Arraedo,M., Molina, E, & Puerto,A. (19%).Effcctsuf lesionsof <he medial parabrachialraucleus(PBI3m):Tastediscrimination arad lithium-chioride-inducedaversiuralearningafterdela>’ed aradcoratiguousinterstimulus intervais.Psychobiology,24, 265-280.
Aguilar, M.A., Mari-Saramiilán,MI., Morant-Deusa,Ji,, &Miñarro, J. (2000). Differerat inhibitiun of CAR by clozapine
as well as DA, Dl, and D2 antagunistsin male mice.BehavioralNeuroscience,114, 389-400.
Aldaverí-Vera, L., Costa-Miserachs,D., Massanés-Rutger,E.,Soriano-Mas,C., Segura-Torres.E. & Morgado-Bernal,1.
(1997). Facilitation of a disíributedshu¡tle-boxcoraditioningwith pusttrairaingintracranialsclf-stimulatioraira oid rats.
Neurobiologyof Learninganó Memory,67, 254-258.Alfonso, D., Santana,C., Rodríguez,M. (1993). Neonatal
lateralizationuf behaviurandbrain dopaminergicasymmetry.Brain ResearchBu//din, 32. 11-16.
Airaiirall, EJ., Aguirre, A., Rial, R.V, Daurat,A., Foret,1., & Benoir,0. (1993).Temperaturedropandsleep:Testirag <he cuntributiuraof SWS ira keepiragcooi. NeuroReport,5, 177-180.
Almiralí, Fi., Niculau, M.C., Gamundi,A., Roselió,C., & Rial,R.V. (1997). Maira trends ira rectal temperatureduring sleep.Hypraugramand thermogram.Neuropsychobioíogy,35, 84-90.
Ambrosio. E., Sharpe, LO., & Pilo<te, NS. (1997). Regionalbinding to curtico¡ropinreleasiragfac¡or receptorsira braira ofrats exposedtu citronie cucaineand cocainewithdrawai.Synapse,25, 272-276.
Amenedo, E., & Díaz, E. (1998). Ageing-rela¡edcharages Inproccssiragof raura-targerand<argel stimuli duringaraauditory
uddball ¡ask. Biological Psychology,48, 235-267.Amenedo,E., & Diaz, E. (1999). Ageing-relatedchangesira ¡he
processiragof atieradedarad unaltendedstandardstimuli.NeuroReport,10, 1-6.
Arias J.L., Alsasua,A., Aher, M., Lorente, L., & Arias, J. (t993).Metabolismof biugenicaminesira experimentalpurtosystemicencephalopathy.Researchiii Surgery,5, 150-153.
Amedo,A., Gallo, M., AgUero, A., Molina, E.. & Puerto,A. (1993).Medulla¿yafferentvagal axotomydismptsNaCI-inducedsitud-termrasteaversioralearning. Behavioraland Neural Rio/cgt
59, 69-75.Atienza, M., Cantero,J.L., Gómez,C.M. (<997). Tite mismatch
raegativity compuraera¡revealsthesensurymemo¡yduriragREMsieepira humaras.NeuroscienceLetters, 237, 1-4.
Azpiruz, A., Arregui, A., Fano, E., Garmeradia,L., & Sánchez-Martín J.R. (1994). Figh¡ing experieracesarad natural killerccli activity ira male Iaboratory mice.AggressiveBehavior,
20, 67-72.Azpiroz.A., Fano, E., Garmendia,L., Arregi,A., Cacho,R., Goitia
O., & Brain, P.F. (1999). Effectsof chronic mild stress(CMS)arad imipramineadmiraistration,ura splen_mononuclearcelí
proliferative response.serumcorticosteronelevel arad brainnorepiraephrineconteratira male mice.Psychoneuroendocrinology,
24, 345-362.Barroso,J., Nieto, A., Olivares,T., Wollmarara, T., & Hernández,
MA. (2000). Evaluaciónraeuropsicoiógicaera la esclerosismúltiple. Revistade Neurología,30, 985-988.
Cadaveira,E., Corominas,M., RodríguezHolguín, 5., Sánchez-Turet, M., & Grau, C. (1994). Reversibility of braira-stemevokedputentialsabraurmalitiesira abstineratcitroniealcoholios:One yearfollow-up. Electroencephalographyanó Clinical
Neurophysiology,90, 450-455.Cadaveira,F., Grau, C., Roso.M., & Sárachez-Turet,M. (1991).
Multimudality exploratioraof evokedpotenílaisira chronic
alcoholies.Alcoholism: Clinical and ExperimentalResearch,
15. 607-611.Carretié,L., & Iglesias,J. (1995). An ERPstudy ora thespecificity
of facial expressionprocessing.International Journal ofPsychophysiology.19, 183-192.
Carretié,U.. Iglesias,i., & Bardo, C. (1998). ParietalNSOO elicitedby emotional visual stimula¡ion.icunial ofPsychophysiology,
12, 376-383.
Carretié, L., Iglesias,J., & García,T. (1997). A study uf titeemotional processiragof visual stimuli tbroughevent-related
putentials.Brain and Cognition, 34, 207-217.Cerro, M.C.R. del ( 1998). Role of <he vomeronasalirapul in
maternalbehavior.Psychoneuroendocrinologw23, 905-926.Cerro, M.C.R. del, Izquierdo.MAR, Ruserablatt,lS., Johnson,
B., Pacheco,P., & Komisaruk.BR. (1995). Brain activityrelated<o maternalbehavior-iraduciragstimuhi ira tite ral. Brain
Research,696, 213-220.Cimadevilla,SM., González-Pardo,H., López,L., Díaz, F., Cueto,
E.G., García-Moreno,L.M., & Arias. S.L. (t999). Sex-related
RESEARCH IN PSYCHOBIOLOGY 233
differeraces in spatial learraing durirag <he early pustnataldevelopmcrat of the rat. RehavioralProcesses,46, 159-171.
Colelí, M., Segarra, MD., & Sabater Pi, J. (1995a). Handpreferencesin chimpanzees(Pan troglodytes),bonobos (Panpaniscus)arad orangutaras (PongoPygmaeus)ira foud-reaching
arad other dail>’ activities. InternationalJourna/of Prirnatology,16, 413-434.
Colelí, M., Segarra, MD., & Sabater Pi, J. (1995b). Manuallaterality ira chimparazees(Pan troglodytes)in complextasks.Joarnal of ComparativePsychology,109, 298-307.
Collado, P., Segovia,5., Calés, SM., Pérez-Laso,C., Rodríguez-Zafra, M., Guiliamón, A., & Valencia, A. (1992). Female’sDHT coratrois sexdiffereraces in the rat bed nucleus of ¡heaccessoryuifactury tract. NeuroReporL, 3, 327-329.
Colmenares, F. (1991).Greeting behaviour betweera malebabuoras:Oes¡rous females, rivalry arad raegotiatiora. Animal Behaviour,41, 49-60.
Colmenares,E <>992). Claris arad harems ira a culony of itamadyasarad hybrid babuoras: Male kinship, familiarity arad <he formation
of broíber-íeams.Behavicur, 121, 61-94.Darbra, S., Balada, E, Garau, A., Gatelí, P., Sala, 5., & Martí
Carboneil, MA. (1995). Perinatal alteratioras of thyroidhormones arad behaviour ira adult rats. Behavioral Brain
Research,68,159-164.Díaz, F., & Zurróra, M. (1995). Auditory evoked potentials ¡n
Down‘s syndrome. Electroencephalography¿md ClinicalNeurophysio/ogyEvokedPotentíais,96, 526-537.
Escera, C., Albo, K., Winkler, 1., & N~atl1nera, R. 3998). Neuralmechanismsof iravoluntary attention tu acoustic novelty aradchange.Jaurnalof CognuziveNeuroscience,10, 590-604.
Escorihuela, R.M., Fernández-Teruel, A., Vallina, lE., Baamonde,C., Lumbreras, M., Dierssen,M., Tobeña,A., & Flórez, J.(1995). A behavioral assessmentof Ts6SDnmice: A putativeDowra syradrome model. NeuroscienceLetzers,199, 143-146.
Escorihuela, RM., Tubeña, A., & Fernáradez-Teruel, A. (1995).Environmental erarichmeraí arad postraatal handling preveratspatial learning deñcits ira aged hypoeniotioraal (Ruinan high-avoidarace) arad hyperemiutional (Rumian low-avoidance)rats.LearningandMemory,2, 40-48.
Escurihuela, R.M.. Vallina, lE, Martínez-Cue, C., Baamonde,C.,Dierssera,M., Tubeña, A., Flórez, J., & Fernández-Teruel. A.(1998). Impaired short-ter¡ra arad lorag-term memory ira Ts65Dramice: A mudel for Duwn syradrome. NeuroscienceLetrers,247,
17 1-174.Espert, R., Navarro, iR, Salvador, A., & Simón, VM. (1993).
Effec¡sof niorphine hydruchloride un social encounters betweeramale mice. AggressiveBehavior, 19, 377-383.
Fernández, J. (¡his issue).Researchtrenés ira Sparaish psychology
(1989-1998).Fernández, R., Méradez, J., & Pásaro,E. (1996). Tumer syndrome:
A study of chromosomal mosaicism. HumanCenetics,98, 29-35.
Fernández-Teruel,A.. Escorihuela,R.M., Castellano,E., González,B., & Tubefla,A. (1997). Neonatalhandiingaradenvirunmental
erarichmen¡effectsura emotioraality,raovelty/rewardseekirag,
arad age-relatedcognitive arad hippocampal impairmerats: Focusura the Romanrat liraes. BehaviorCenetics,27, 513-526.
Freire-Garabal, M., Núñez-Iglesias, M.J., Losada, C., Pereiro-Raposo,MD., Riveiro, P., Fernández-Rial, SC., García Vallejo,M., Mayan, SM., & Rey-Méndez,M. (1996). Inhibi¡ury effects
uf buspironeura the enhancementuf lurag metasíasesinducedby operativestressin rats. ResearchConimunicationsira
Biological Psychologyorad Psychiatry,21, 13-25.Freire-Garabal, M., Núñez-iglesias,M.J., Rey-Méndez,M,, Pereiro-
Raposo,MD., Riveiro, P., Fernández-Rial, SC., Losada,C.,Garadoy, M., & Mayan, J.M. (1998). Effects of ampbetamineun the developraicral of Moloney sarcomavirus-induced tumorsIra mice. Oncology Reporís 5, 381-383.
Gallo, M., Márquez, S.L., Ballesteros, MA., & Maldonado, A.(1999). Furactiunal blockade of dic parabrachial area it>’tetrudotoxira disrupís [he acquisition of conditioned tasteaversiun induced by rnotion-sicknessira rats. New-oscienceLeuers,265, 57-60.
Gallo, M., Valouskova,Y, & Cándido,A. (1997).Fetal hippocampaltrarasplaratsrestorecoraditionedblockirag ira rats with dorsalhippocampallesions:Effectof age.BehavioralBrain Research,
88, 67-74.Gil-Rurmaran,C., Pe>áez,E., & Sánchez,5. (>998). Variatiuras ira
cumpetitive mechanismsof captive male hamadryas-like
babouns ira two feedingsituatioras.Primates,39, 473-484.Giuffrida, A., Parsoras,L.H., Kerr, T.M., Rodríguezde Fonseca,
E, Navarro,14, & Piomelli, D. (1999). Dupaniineactivadoraof eradugenouscannabinoid sigraaling ira dorsal striatum. Nana-eNeuroscience,2, 358-363.
Gómez, C., Atieraza, M., López-Mendoza,D., & Vázquez, M.(1995). Cortical poteratials associated[o visual stimuii aradmanual responses durirag gap arad non gap paradigms.NeuroscienceLeuers, 186, 107-110.
Gómez, C., Clark, VP., Fan, 5., Luck, S.S.,& ízlillyard, 5-A. (1994).Sourcesof a¡tentiora-sensi¡ivevisual event related poteratials.Brain Topography,7, 41-51.
Gómez-Amor,1., Martínez-Selva, SM., Romára, E., & Zamora, 5.(1990). Electrodermal activity ira menstrualcycle phases:Acomparison of within- arad between-subjectsdesigras.InternationalJournal of Psychophysio/ogy,9, 39-47.
Gómez-Amor,J., Martínez-Selva, J.M., Runiára, E, Zamora, 5., &Sastre,lE. (1990). Electrodermalactivity, hormonalleveisaradsubjectiveexpericraceduring ¡he merastrualcycle. Bio/ogical
Psychology,30,125-139.Gómez-Laplaza,L.M., Morgara, E. (1993) Social isolatiora,
aggressiura,arad dominance ira aí¡acks ira juvenile angelfisb,Pterophy//umsca/are.AggressiveBehavio519. 213-222.
Gorazález-Gonzáiez,5., Diaz, E., Vallejo, G., Arias, J.L. (1996).Functional sexual dimurphism of <he nucleolar orgaraizer regiorasira ¡he tuberomamillary raucleus. Dram Research,736, 1-6.
Grau, C., Escera, C., Cilveti, R., García, M., Fernández, J.R.,Mojón, A,, & Hermida, R. (1995).Ultradiara rhythms ira grussmotor activity of adult humaras. Physiologyand Behavior, 57,411 -419.
234 HERREROSDE TEJADA AND MUÑOZ TEDÓ
Grau, C., Escera,C., Yago, E., & Polo, MD. (1998). Mismatchnegativity arad auditory sensorymemoryevaluatiora:A newfasterparadigin.NeuroReport, 9. 2451-2456.
Guillazo-Blancit,G.,Vale-Martínez,A, Marsí-Nicolovius,M., Cotí-
Andreu, M., & Morgado-Bernal,1. (1999). Ihe parafascicularraucleusarad ¡wo-way activeavoidarace:Effec¡s of electricalstimulatiora arad electrodeimplaratation. ExperimentalBrainResearch,129, 605-614.
Hackley,SA., & Valle-Inclán, F. (1998). Automaticalertiragdoes
not speedlatemutorieprucessesira areactiontime.task. Narure,391, 786-788.
Herrerosde Tejada,E, Creen D.C., & Muñoz Tedó,C. (1992).
Visual thresholdsira albino arad pigmentedrats. VisualNeuroscience,9, 409-414.
Herrerosde Tejada,P.. Muñoz Tedó, C. & Costi, C. ([997).Behaviuralestimatesuf absolutevisual thresholdin mice. VisionResearch,37, 2427-2432.
Junqué,C., & Vendrelí, 1’. (¡997). Consecuenciasraeurupsicológicasde la asfixia perinatal.Acta Luso-Españolade NeurologíayPsiquiatría,25, 182-188.
Jurado,MA., Bartomeus,F., & Suraqué,C. (1993). Secuelasneuropsiculógicasera los tmumatismoscrar¡eoeracefálicos.Relaciónentreel déficit objetivo y el subjetivo. Neurología,8, 91-98.
Kovoor, J., Muñoz-Cuevas,A., & Ortega-Escobar.J. (1993).Microanatoin>’of <he anteriormedian eyesarad its pussiblerelation ¡o polarized-light reception ira Lycosa tarentula(Araneae,Lycosidae). Bolletino di Zoologia, 613, 367-375.
León, Ml., & Purtellano,SA. (1999). Depresióninfantil: su relacióncon la lateralidady la asimetríade lasfuncionescognitivas.
ArchivosdeNeurobiología,62, 35-48.
López,L., Burgos, 1’., Saratíra,LS., Begega,A., Añas,J., Lorente,L., & Arias, S.L. (1997). Purtacavalshuntcontrol animals:Physiologicalconsequencesderived from the shamoperation.
Lib Animal, 31, 225-230.
López Alonso, J.C., & Gómez-Jarabo,G. (2000). A model of<herapeuticalaction ira panicdisorders.LuropeanJournal of
Psychiatry,14, 42-51.Martí Carbonelí,MA., Sanz,C., Darbra, 5., Garau,A., & Balada,
F. (1993). Is prolactinrelatedwith activity arad emotionalreactivity?PhysiologyandRehavior53, 827-829.
Martín-Loeches,M., Góniez-Jarabo,G., & Rubia,F.J. (1994).
Human braira potentialsof spatial locatiora encodirag ratomemory. Electroencephalographyarad Clinical Neurophysiology,91, 363-373.
Martín-Loeches,M., Valdés,B., Gómez-Sarabo,G., & Rubia,F.S.(1998). Working memory within <he ventral s¡ream:Brairapotentialsof spatial locationandmotiora directioneracodingintomemor>’. InternationalJaurnalof Neuroscience,96, 87-lOS.
Martínez, M., Salvador,A., & Simón,VM. (1994). Behavioralchangesoverseveralsuccessfulaguraisticencountersbetweeramale mice: Fffect of type of “standardopponent.’Ag,gressiveBehavior, 20, 441-451.
Martínez,MP., & Botella, C. (1996). Evaluacióny tratamientopsicológico de la hipocondría:revisión y análisiscritico.PsicologíaConductual,4, 29-62.
Martínez-Sanchís,5., Brain, EF., Salvador,A., & Simón,VM.(¡996). Lorag-¡ermchronic treatmentwith Stanuzolol lacks
significanteftectsun aggressionarad activi¡y ira young aradadull male laborator>’ mice. GeneralPhannacology, 27, 293-298.
Martíraez-Sanchís,5., Salvador,A., Moya-Alhiol. L., González-Bono,E.. & Simón,VM. (1998). Effcctsof chruraic treatment
of testosteronepropionateura aggressiunarad hormonalleveisun intact male mice. Psvchoneuroendocrinology,23, 275-293.
Mataix, U., .lunqué,C., Vallejo, 5.. Sáncl-¡ez-Turet,M., Verger, 1<.,
& Barrios, M. (1997). lvlemisphericfuractionalimbalanceira asub-clinical obsessive-cumpulsivesampleassessedby theContinuous PerformanceTest, <deratical Pairs Version.PsychiatrvResearch,72, 115-126.
Mataró, M., & Junqué,C. (1998). QuantitativeMRI murphumetricaraalysisof raeurodevelopmentaldisorders.Medical Imaging
International, 8, 6-8.Mediavilla, C., Molina, F., & Puerto,A. (1998). Bilateral lesiuras
ira <he cerebellarintemositus-dentateregiora impair tasteaversioralearrairag ira rats. Physiologya,ídBeliavior, 65, 25-33.
Morales, A., Cubero, 1., & Puerto, A. (1989). Mammillarypolydipsia araddiabetesinsipidus:A study of tite rhythmicity
of water intake. Physio/ogyandRehavio~45, 911-915.Morales,A., Torres,MD., Megias,S.L.. Cándido,A., & Maldonado,
A. (1992)Effectof Diazepamun successivenegativecoratrastIra one-way avoidance,PI¡armacology Biochemistryaud
Bchavior 43, 153-157.Moro, M., Salvador,A., & Simón,VM. (1997). Effects of the
repeated admiraistratioraof d-amphetamineun agonisticbehaviourof isolatedmale mice.Behavioura/Pharmaco/ogv,
8. 309-3<8.Mozaz,Mi., Martí, LE., Carrera,E., & DeLa Puente,E. (1990).
Apraxia ira a patientwith lesiora locatedira right sub-cortical
area.Cortex, 26, 651-655.Mozaz,Ml.. Peña,i., Barraquer,L.L., Martí, 5, & Goldstein, L.
(<993). Useof bod>’ partasobjectin brain-damagedpatients.The Clinical Neuropsychologist,7, 39-47.
Nadal,Fi., Prat,O., Pallarés,M., Hernández-Torres,M., & Ferré,N. (1996). Effects of brumocriptineun self-admiraistrationofsweetenedethanolsolutioras ira rats.Psvchopharmacologv, 128,
45-53.Navarro,SE., Miñarro, 5., & Simón,V.M. (1993). Aratiaggressive
arad motor effects of haloperidolshow differerat temporal
patternsira <he developmentof tolerance.Phys¿ologyanáBehavior, 53, tOSS-1059.
Navarro, M., Rubio, E., & Rodríguezde Fonseca,F. (1995).Behaviouralconsequeracesof maternalexposuretu natural
cannabiraoidsin rats. Psychophormaco/ogy,122, 1-14.Nieto, A., Barroso,1., Olivares,1., Wullm-an,T., & Hernández,M.
(1996).Alteracionesneuropsicológicasen la esclerosismúltiple.
PsicologíaConductual,4,401-416,Nieto, A., Hernández,5., González-Feria,L., & Barroso.5. (1990).
Semanticcapabilitiesof tite <cft aradright cerebralhemispiteresIra categorizatioratasks:Effecsuf verbal-piciorialpresentatiora.Neuropsychologia,28, 1175-1186.
RESEARCHIN PSYCHOBIOLOGY 235
Nieto, A., Saratacruz,Fi., Hernández,5., Camacho-Rosales,J., &
Barroso,J. (1999). Hemisphericasymmetiyira lexical decisioras:The effectsof grammaticalclassarad imageability.Brain and
Linguage, 70, 421-436.Ortega-Escobar,J., & Muñoz-Cuevas,A. </999). Anterior median
eyes of Lycosatare,ítula (Araneae,Lycosidae)detectpolarized
light: Behavioralexperimentsaradelectroretinographicanalysis.Journal of Arachno/ogy,27, 663-671.
Pallarés,MA., Nadal,RA., Hernández-Torres,M., & Ferré,N.A.
(1997). EtOH self-admiraistrationun shuttlebox avoidancelearniragaradextiractiun ira rats. Alcohol, 14, 503-509.
ParraA., Arenas,MC., Moralcón, 5., Vinader-Caerols,C., & Simón,
V. (1999). Sex differeracesira the effectsuf neurolepticsoraescape-avoidaracebehaviorira mice:A review. Pharmacology,BiocheníistryandBehavior, 64, 8 13-820.
Pásaro,E., Fernández,Fi., & Méndez, 5. (1993). Optical derasity
profile araalysis of trypsira-giemsabarads ira human X-chromosomes.Annals of HumanGenerics,57, 117-121.
Peinado-Manzano,MA. (1994)Amygdala, hippocaraipusaradassociativememor>’ ira rats. RehavioralBrain Research,61,175-190.
Peinado-Manzano,MA., & Pozo-García,Fi. (1996). Retrogradeamnesiaira rats with dorsomedialthalamicdamage.BehavioralDram Research,80, 177-184.
Perea,MV., & Ladera, V. (1997a).Interacciónentreel déficitneuropsicológicoen ejecución y la competenciaen lasactividadescotidianasen la demenciatipo Alzheimen Revista
deNeurología,25, 513-518.Perea,MV., & Ladera,V. (1997b).Rendimientospráxicosy grado
de perfusión cerebral por SPECT en la demenciatipo
Alzheimer. Psicothema,II, 339-408.Perea,MV., Ladera, V., Blanco,A., & Morales,E (1999). Árbol
de decisióndiagnósticapara la correctautilización de las
técnicasdeevaluaciónraeuropsicológicaen el traumatismocraraeuencefálico.Revistade Neurología,28, 999-1006.
Persico,AM., Sehindíer,C.W., Davis, SC.,Ambrosio, E., & Uhí,
GR. (1998). Medial prefrontalcortical injectiorasof c-fosantisenseoligoraucleutidestransientlylower c-Fusproteiraarad
mimic amphetaminewithdrawal behaviours.Neuroscience.82,1115-1129.
Eolo, MD., Escera,C., Gual, C., & Grau, C. (1999). Mismatchnegalivil>’ aradauditorysensor>’ memor>’ ira citroraic alcuholics.
A/coho/isni:Clinical and ExperimentalResearch,23, 1744-1750.Portellano, SA., Mateos, R., & Martínez Arias, R. (2000).
CUMANIN.Madrid: TEA.Portellano,SA., Mateos,Fi., Valle, M., & Aizcun, 5. (1997).
Trastornosneuropsicológicosen niños demuy bajo pesoalnacerera edadescolar.ActaPediátrica, 55, 375-379.
Portellano,JA., & Robles,5.1. (1998). Lateralidady funciones
cognitivas.Estudiodesu interacción.ClinicaySa/ud,9, 549-562,Pringatano,GE., Bruna, O.,Mataró, M., Muñoz,J.M., Fernández,
5.. & Junqué.C. (1998). Iraitial disturbancesfur conscíousraess
arad resultaratimpairedawarenessira Spanishpatientswithtraumaticbrain injury. Joí~rnalofHead TrauníaRehabilitation,
5, 29-38.
Pujol, J., Juraqué,C., Veradrelí,P., Grau, J.M., & Capdevila,A.(1992). Reductiorauf the substaratiaraigrawidth arad motor
declineira agirag aradParkinsora’sdisease.Archives of Neurology,49, 1119-1122.
Ramírez,3M. <>993). Acceptabilit>’of aggressiorain fuur Sparaishregiorasarad a comparisonwi¡h othcr Europearacuuntríes.AggressiveBehavior, 19, 185-197.
Ramírez,SM. (1998). Aggressiora.Ira G. Greenberg& MM.Haraway(Eds.), Comparativepsychology:A handbook(PP.
625-634).New York: Garlarad.Ramos, J.M., Castillo, MF., & Puerto,A. (1989). Peripheral
pathways mediatirag salivar>’ secretiun after raucleus
parvucellularisactivatioraira therat. Brain ResearchBulletin,22, 469-473.
Ramos Platón,MS., & EspinarSierra,J. (1992). Charagesirapsychopathologicalsymptomsira sleepapneapatientsaftertreatmeratwith nasal cuntinuouspositive airway pressure.InternationalJoarnal ofNeuroscience,62, 173-195.
Rodríguez-Arias,Nf., Miñano, 1., Aguilar, A., Pinaza,1., & Simón,VM. (1998). Effects of risperidonearad SCtA 23390 oraisulatiora-iraduced aggressiora ira male mice. EuropeanNeuropsychopharmacology,8, 95-103.
RodríguezdeFonseca,E, Carrera,M.R.A., Navarro, M., Koob,G. F., & Weiss,E. (1997).Activationuf corticutropira-releasirag
factor ira <he limbie systemdurirag cannabinoidwithdrawal.Science,276, 2050-2054.
RodríguezdeFonseca,E., del Arco, 1., Martin-Calderón,J.L.,Gorriti, MA., & Navarro,M. (1998). Role of <he endugeraouscannabinoidsystemira <he regulatioraof motor activity. Ira F.Rodríguezde Fonseca& M. Navarro(Eds.),Neurobio/ogyofDisease ISpecial issuc: Neurobiology of cannahinoid
transmission],5,483-501.RodríguezHolguín, 5., Corral, M., & Cadaveira,E. (1998a).Visual
arad auditoryevent-relatedpotentialsira youragchildreraofalcuholicsfrom high arad low density families. Alcoholistn:Clinical anóExperimentalResearch,22, 87-96.
RodríguezHolguín, 5., Corral, M., & Cadaveira,E (1998b). Event-relatedpo¡en¡ialselicited by infrequent nora-targe¡stimuli inyoung chiléreraof alcohulics. Famil>’ histur>’ arad geraderdiffereraces.Alcohol andAlcoholism,33, 281-290.
RodríguezPérez, C., Vicente, F. de, & Gómez-Jarabo,G. (1992).
Effectsof protein malrautritionaraddicadministradorauf cortisulura <he reflexologiedevelopments.BehaviouralandNeuralDio/ogy, 58, 165-170.
Rotzirager.5., Aragón, C.M.G., Rugan,E, Amir, 5., & Amit, Z.
(1995).Thenitric oxide syrathaseinhibitur Nw-raitro-L-argirairaemethylesteratterauatesbraira catalaseactivity ira vitro. Life
Sciences,56, 1321-1324.SabaterPi, 5., Vea, S.J., & Serrallunga,5. (1997). Did tite first
hominidsbuild nests?CurreníAnthropology,38. 914-916.Salas,C., Herrero,L., Rodríguez,E., & Torres, E. (1997). Tectal
codificatiura of eyemovemen¡sira goldfishstudied by electricalmícrustimulation.Neuroscience,78, 271-288.
Salas,C., Rodríguez,E, Vargas,SP., Durán,E.. & Torres, 8. (1996).Spatial leamingarad memorydeficits aftertelencephalicahíation
236 HERREROSDE TEJADA AND MUÑOZ TEDÓ
ira guldfish trained ira place arad turra mazeprocedures.BehavioralNeuroscience,110, 1-16.
Sarachis,C., Suay, E, Valverde, MS., & Salvador,A. (¡997).Non-metabulic VCO2 responsestu ara iracrementalexercisetest irajudoistsira [hecompetitiveseasun.Biologyof Sport, 14, 29-36.
Sarachís-Segura,C., Miquel, M., Conca,M., & Aragora,C.M.G.
(1999).Cyanamidereducesbrain catalaseandethanol-iraducedlocomotor activity: Ls ¡here a furactiunal link?Psychopharmacology,144,83-89.
Saradi,C., Borrelí, 5., & Guaza,C. (1990).Administratioraof leu-
enkephalinimpairs <he acquisitionof preferencefur etharaol.Psychopharmaco/ogy.100, 350-354.
Sandi,C., Castaraun,N.. Vitiello, 5., Neveu, P.J., & Morméde. P.(1991). Different resporasivenessof spleenlymphocytesfromtwo linesof psychogeraeticallyselectedrats (Rumarahigh- aradluw-avoidarace).Jaurnalof Neuroimmuno/ogy,31, 27-33.
Sandi,C., Luscertales,M., & Guaza,C. (1997). Experieracearadtime-deperaderateffectsof corticusteroneun spatialmemoryirarats. Europea»Journa/of Neuroscierace,9,637-642.
Sandi,C., Patterson,T.A., & Rose,S.P.R.(1993). Visual iraputaradlateralizationof brain furactiura ira learrairag ira ¡he chick.
Neuroscienee,52, 393-401.Sandi,C., & Rose,S.PR.(1994). Curticusteroidreceptorantagoraists
areamraesticfor passiveavuidanceleamirag ira day-uldchicks.BumpeanJoarnal ofNeuroscience,6, ¡292-1297.
Santana,C., Muujir, E, Fajardo,N., Castaneira,A., Hernández,EJ. & Abreu, P. (1994). Charagesira tyrosirae hydroxylaseactivity and melatorainsynthesisira rat pineal glandstbruughout72 hoursof iracubatiun.NeuroscienceLetters, 173, 119-123.
Segovia, 5.. Cerro, M.C.R. del, Ortega,E., Pérez-Laso,C.,Rodríguez-Zafra,M., Izquierdo,M.A.P., & Guillamóra, A.(1996). Rule of GABAA receptorsin ¡he organizatiuraof brairaarad behaviouralsexdiffereraces.NeuroReporr,7, 2553-2557.
Segovia,5., & Guillamón,A. (1993). Sexualdimorphisni ira <hevomeronasalpatbway arad sexdiflerencesira reproductivebehaviors.Brain ResearchReview, 18, 51-74.
Segovia,5., Guillamóra,A., Cerro,M.C.R. del, Ortega,E., Pérez-Laso, C., Rodríguez-Zafra,M., & Beyer, C. (<999). The
developmeratof brairasexdiffereraces:A multisignalingprocess.BehavioralDram Research,105, 69-80.
Segovia,5., Pérez-Laso,C., Rodríguez-Zafra,M.. Calés,J.M., Del-Abril, A., De-Blas,MR., Collado,P, Valencia,A.. & Guillamóra.A. (1991). Early postraatalDíazeparnexposurealtassexdiffereracesira ¡he rat braira. Dram ResearchBulletin, 26, 899-907.
Serra,SM., Escera,C., Sánchez-Turet,M., SánchezSastre,J., &Grau, C. (1996).Ihe Hl-receptoraratagoraistchlorpherairaminedecreases¡he endiragphaseof <he mismatch raegativityof thehumanauditoryevera¡-relatedpoteratials.NeuroscienceLetters,203, 77-80.
Serrano, J.M., Iglesias, J., & Loeches, A. (1992). Visualdiscriminatioraarad recognitionof facial expressiorasof arager,
fear, andsurpriseira 4- tu 6-morath-oldirafarats.Developmental
Psychobio/ogy,25, 411-425.Suay,F., Salvador,A., González-Bono,E., Sanchis,C., Simón,
VM., & Moratoro, SE. (¡996). Testosteronay evaluacióndelaconductaagresivaenjóvenesjudokas.RevistadePsicología
del Deporte,9-10, 79-91.Teraas-Huerga,M.. Cull-Aradreu, M., Guillazu-Blarach,G.,Martí-
Niculuvius,M., & Morgado-Bemal,1. (1998)Facilitatoryeffec¡sof thalamicreticular raucleuslesiorasupora two-way activeavoidanceira rats. ExperimentalDram Research,118, 5<1-516.
Torras-García,M.. Portelí-Cortés,1., Cos¡a-Miserachs,D., &Morgado-Bernal,1. (1997)Lorag-¡ermmemorymodulatiorabyposttrainiragepiraephriraeira rats: Differera¡ial effectsdeperadingora ¡he basic learning capacity.BehavioralNeuroscience,III,301-308.
Torres,C.. Morales, A., Cándido,A., & Maldonado,A. (1996).
Successiveraegativecora¡rastira urae-wayavoidance:Effect of¡hioperatalsodium arad chlorpromazirae.Europeati JaurnalofFharmacology,3/4, 269-275.
Vale-Martínez,A., Guillazu-Blanch,O.,Aldavert-Vera,L., Segura-Torres,P., & Martí-Nicolovius, M. (1999). Iratracranialself-
stimulatiura ira <he parafascicularnucleusuf the rat. DramResearchBu//edn,48, 401-406.
Valencia,A., Collado,E, Calés,J.M., Segovia,5., Pérez-Uso,C.,Rodríguez-Zafra,M., Guillamóra, A. (1992). Postnataladministratiuraof dihydrotestosteroneto ¡he malerat abulishessexualdimurphismira ¡he accessolyulfactur>’ bulb: A vulumetricstudy.Developmenta/Dram Research,68, 132-135.
Valle-Inclán, F. (1996). The locusuf interfereraceira ¡he Simóneffect:An ERPstudy.Biological Psychology.43.147-162.
Vea,J.J.,& SabaterPi, 1. (1998).SpontaneouspoiratingbehaviourIra ¡he wild pygmy chiparazee (Pan paniscus). FoliaPrimarologica,69, 289-290.
Vendrelí,P., Pujol, 5., Junqué,C.. & Martí-Vilalta, J.L. (1995).Memor>’ disfunctiurasira patientswith vascularsubcortical
patholugy.PoasandResearchira Gerontology.(supplemerat),75-82.
Verger. K.. Suraqué,C., García,C., Pardo,N.. Martí-Vilalta, S.L.(1996). Trastornosraeuropsicológicuspor lesiónen el sistema
froratoestriadoizquierdo. Estudiolongitudinalde ura adolescente.Neurología, 11, 44-47.
Vicente E.. de, RodríguezPérezMC., & Gómez-Sarabo,0. (1991).The effectsuf prutein malrautrition arad cortisul treatmenturamotoractivity uf rats.BehavioralProcesses,25, 1-14.
Ziraner, D.. & Peláez,F. (1999).Verreaux’scagles(Aquila verreauxi)aspotential predaturaof hamadryasbabuoras(Papiohamadtyas)ira Eritrea.AmericanJaurnalof Primatology,47, 61-66.
Zurrón, M., & Díaz, E. (1995). Auditor>’ arad visual evukedpoteratialsira subjectswith urgaraicandcultural-familialmentalretardatiora.AmericanJournalon MentalRetardation, 100, 3,271-282.