the citric acid cycle kadek rachmawati. the citric acid cycle = kreb’s cycle = tricarboxy- lic...
TRANSCRIPT
![Page 1: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/1.jpg)
THE CITRIC ACID CYCLE
Kadek Rachmawati
![Page 2: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/2.jpg)
The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that
oxidized Asetyl-CoA Occur in Mitochondria To yield energy (ATP) TCA cycle the final common pathway for the
aerobic oxidation of carbohydrate, lipid and protein
![Page 3: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/3.jpg)
TCA cycle is common pathway for carbohydrate, lipid and protein
![Page 4: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/4.jpg)
TCA cycle pathway
![Page 5: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/5.jpg)
The function of TCA cycle :
1. Oxidized of Acetyl CoA ATP
( 1 mol Acetyl CoA 12 mol ATP ) 2. The citric acid cycle is AMPHIBOLIC :
- it can oxidized to yield ATP
- it is important in the provision of carbon skeletons for gluconeogenesis, fatty acid synthesis and interconversion of amino acid
![Page 6: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/6.jpg)
Vitamins play key roles of the Citric Acid Cycle
Four of the B vitamins are essential in the citric acid cycle :
1. Ribovlavin FAD
2. Niacin NAD
3. Thiamin TPP
4. Pantothenic acid CoA The B vitamins are essential in energy yielding
metabolism by dehydrogenase enzyme :
- FAD 2 mol ATP
- NAD 3 mol ATP
![Page 7: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/7.jpg)
INHIBITOR OF TCA CYCLEINHIBITOR OF TCA CYCLE
1. Fluoroacetate1. Fluoroacetate• Condensation with CoA Fluoroacetyl-CoACondensation with CoA Fluoroacetyl-CoA• Condensation FluoroacetylCoA with Oxaloace-Condensation FluoroacetylCoA with Oxaloace-
tate tate Fluorocitrate Fluorocitrate inhibit Akoni-inhibit Akoni-
tase enzyme accumulation of citratetase enzyme accumulation of citrate• Fluoroacetate pesticideFluoroacetate pesticide
2. Malonate suksinat dehydrogenase 2. Malonate suksinat dehydrogenase enzymeenzyme
3. Arsenite 3. Arsenite αα-ketoglutarate dehydrogena--ketoglutarate dehydrogena-
se enzymese enzyme
![Page 8: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/8.jpg)
Participation of TCA cycle in fatty Participation of TCA cycle in fatty acid synthesis from glucoseacid synthesis from glucose
![Page 9: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/9.jpg)
Involvement of TCA cycle in Involvement of TCA cycle in transamination and transamination and
gluconeogenesisgluconeogenesis
![Page 10: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/10.jpg)
REGULATION OF TCA CYCLE
![Page 11: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/11.jpg)
REGULATION OF TCA CYCLE
![Page 12: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/12.jpg)
REGULATION OF TCA CYCLE
![Page 13: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/13.jpg)
REGULATION OF TCA CYCLE
![Page 14: THE CITRIC ACID CYCLE Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA](https://reader036.vdocuments.us/reader036/viewer/2022062422/56649ee05503460f94bf0ad9/html5/thumbnails/14.jpg)