chemistry 12-citric-acid-cycle
TRANSCRIPT
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Chapter 12 (part 1)
Citric Acid Cycle
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Gylcolysis
TCA Cycle
Electron Transport andOxidative phosphorylation
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Entry into the TCA Cycle
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Pyruvate Dehydrogenase
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Citrate Synthase• Only step in TCA cycle that involves the
formation of a C-C bond
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Aconitase
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Isocitrate Dehydrogenase
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-Ketoglutarate Dehydrogenase
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Succinyl-CoA Synthetase
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Fumarase
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Malate Dehydrogenase
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Reduced Coenzymes Fuel ATP Production
• Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20 HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+
• Isocitrate Dehydrogenase 1 NADH=2.5 ATP• -ketoglutarate dehydrogenase 1 NADH=2.5
ATP• Succinyl-CoA synthetase 1 GTP=1 ATP• Sunccinate dehydrogenase 1 QH2=1.5 ATP• Malate Dehydrogenase 1 NADH=2.5 ATP
• Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA
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Regulation of TCA
Cycle
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Protein/amino acid
Catabolites feedInto the TCA
Cycle
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Fats breakdown and feed
into the TCA Cycle
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TCA Cycle provides intermediates for many biosynthetic processes
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The Anaplerotic ReactionsThe "filling up" reactions
• PEP carboxylase - converts PEP to oxaloacetate
• Pyruvate carboxylase - converts pyruvate to oxaloacetate
• Malic enzyme converts pyruvate into malate
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Following the carbons through
the TCA cycle
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