the animal welfare body and implementation of the...
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The animal welfare body and implementation of the 3Rs
Norwegian Consensus Platform for replacement, reduction and refinement of animal experiments
www.norecopa.no
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3R-implementation is an important tool in preparing for ethical evaluation – in everyone’s interest.
Bateson’s decision cube: all about avoiding the solid blocks…
Bateson, P. (2005) Ethics and Behavioral Biology. Advances in the Study of Behavior, 35, 211-233.
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Don’t hide 3R information in scientific papers on something else
Title & abstract
important!
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The need for collaboration between regulators, scientists and technicians
• The scientists are the ones with the best insight into the literature in their research field = responsibility
• They are often not experts on LAS, 3R-resources and literature searching – use 3R information specialists
• We have no single Journal of Alternatives • They rarely use 3R-terms when writing up their research
• Scientists may not have sufficient insight into the daily challenges of running an animal facility and the indirect costs of their research (e.g. technician time/motivation, health monitoring)
• Involve everyone from the first meeting, before rumours begin to circulate • Get the technicians on your side • The value of a good non-technical summary • Invite key researchers to explain their projects • Comment upon ”the Emperor’s new clothes”, ask the ”so what?” question
and listen to the opponents • Use statisticians to check the study design
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Don’t forget the 3 S’s
• Good Science • Good Sense • Good Sensibility
Carol Newman
Use your heart as well as your head. Give the animals the benefit of the doubt. Happy, healthy animals cared for by ditto technicians give the best (correct) results in an experiment.
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Focus on Alternatives (FoA), UK
A consortium of UK animal
welfare organisations
http://www.frame.org.uk/dynamic_files/foaposter_plannning.pdf
and
http://www.frame.org.uk/dynamic_files/
foaposter_planningb.pdf
EARLY PLANNING FOR A PROJECT WHICH MIGHTINVOLVE THE USE OF ANIMALS
Scientists using animals in scientific procedures have an ethical and legal obligation to ensure that the Three Rs,namely Reduction, Refinement and Replacement, are implemented wherever possible. This strategy wasdesigned by the Focus on Alternatives1 group to help scientists meet this obligation. The strategy should beapplied at the beginning of a project, and at regular intervals throughout. Advice should be sought from theEthical Review Process and Home Office Inspectorate.
PROJECT WHICH MIGHT INVOLVE USE OF LIVING ANIMALS
DEFINE RESEARCH OBJECTIVES CAREFULLY
LITERATURE SEARCHES OF SUBJECT-SPECIFIC DATABASES (CONSULT INFORMATION PROFESSIONAL)
v TO AVOID DUPLICATION v TO IDENTIFY ALL POSSIBLE APPROACHES
IS THE PROJECT STILL RELEVANT AND NECESSARY?
CAN IT BE DONE ENTIRELY WITHOUT LIVING ANIMALS?
GO AHEAD. PUBLISH DATA HIGH-LIGHTING THREE Rs ASPECTS
(e.g. IN KEYWORDS, ABSTRACT &MATERIALS AND METHODS)
GATHER INFORMATION
YES
YES
YES
NO
NO
NO
RETHINK
IMPLEMENT REDUCTION AND REFINEMENTMETHODS (e.g. STRAIN, NUMBERS, SOURCE,
TECHNIQUE, HUSBANDRY)
CONTACT INDIVIDUALS WITH RELEVANT EXPERTISE
v IN THE THREE Rsv IN NEW TECHNIQUES
1Membership of the Focus on Alternatives committee includes the Dr Hadwen Trust, FRAME, The Humane Research Trust, TheLord Dowding Fund, RSPCA, St Andrew Animal Fund and UFAW. Copies of the poster are obtainable from FRAME, 96-98 NorthSherwood Street, Nottingham, NG1 4EE. Tel: 0115 958 4740. Fax: 0115 950 3570. E-mail [email protected].
SEARCHES OF SPECIALISED THREERs RESOURCES
(CONSULT INFORMATION PROFESSIONAL)
v WEBSITESv INTERNET DISCUSSION GROUPS AND
MAILING LISTSv DATABASES
Specialised resources are listed in the Guide toSearching for Alternatives to the Use ofLaboratory Animals (http://www.frame.org.uk).
CAN A PILOT STUDY OR OTHER PARTOF THE STUDY BE DONE WITHOUT
LIVING ANIMALS?
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3R-implementation cannot be properly addressed until the objectives of the project have been clearly stated! Example: the use of animals in teaching and training
• Teaching and practising: - laboratory skills - animal handling skills - preparation-specific animal skills
• Imparting good ethical thinking • Data handling skills • Experimental design skills • Communication skills (oral, written) • Groupwork • Staff-student interaction
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The NORINA database http://oslovet.norecopa.no/NORINA
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http://film.oslovet.norecopa.no
’We may need the animals, as it were, on the night; but the machines will do very well at rehearsals’(Russell & Burch)
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Quality assurance at all levels of the animal facility will increase 3R implementation • SOPs describing good techniques, carried out by
competent operators • Checklist (contract) between researcher and the facility • The AAALAC Program Description template as an overall
performance checklist • Institutional policies on animal care and use • Animal environment, housing and management • Veterinary care • Physical plant
• A Master Plan as a daily checklist for the whole facility + the necessary literature/resources/finances/support to implement these
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Canadian Council on Animal Care (CCAC) + Guidelines for lab, farm, fish and wildlife research
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THE ECVAM SEARCH GUIDE
DATA RETRIEVAL PROCEDURESBasic PrinciplesAnnett J. Roi, Barbara Grune
EDITED BYAnnett J. Roi, Jon Richmond
EUR 24391 EN - 2011JointResearchCentre
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3R centres
www.nc3rs.org.uk
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National Consensus Platforms (ecopa)
www.norecopa.no
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National Consensus Platforms (ecopa)
International Consensus Meetings representing all stakeholders, with all presentations, guidelines and consensus document on the internet: wildlife, fish and agricultural animals
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• General information on laboratory animal science and the 3Rs
• Guidelines for the 3Rs when planning and reporting animal research
• NORINA database of audiovisual alternatives • TextBase database of textbooks within LAS • Overview of 3R-databases
Institutional 3R-websites, e.g.
oslovet.norecopa.no
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• Email discussion groups e.g. CompMed, VOLE, LAREF, consensus meeting forum, all Norway’s lab animal facility managers
• Journals and their theme numbers e.g. Altex, Animal Welfare, ATLA, ILAR Journal, Laboratory Animals
• Review papers e.g. Guidelines for health and welfare monitoring of fish used in research. Laboratory Animals, 2006, 40: 323-340
• Proceedings e.g. ECVAM workshops; World Congresses on Animal Use and Alternatives; Harmonisation of the Care and Use of Fish/Wild Animals/Agricultural Animals in Research
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Information specialists: librarians with competence in searching and knowledge of LAS
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AJ Smith & T Allen, 2005 The use of Databases, Information Centres and
Guidelines when planning research that may involve animals
Animal Welfare, 14 (4): 347-359
www.nal.usda.gov/awic/newsletters/v13n3/AWICBulletinV13N3.pdf
Access to an overview of guidelines, e.g.