July 25-29, 2021University of PennsylvaniaSchool of Dental MedicinePhiladelphia, Pennsylvania

www.dental.upenn.edu/pennperio2021

Penn PeriodontalC O N F E R E N C E 2 0 2 1

THE 5TH

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Oral session for junior investigators selected from submitted abstracts

Sunday, July 25, 2021

LOCATION ARTHUR E. CORBY AUDITORIUM (B-13)

MODERATOR: Daniel P. Miller

7:00 PM P. gingivalis Exacerbates OSCC Through Controlling PD-L1 And CD8+ T Cells Junling Ren

7:15 PM Stromal cell-derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis Hui Wang

7:30 PM Mechanical Regulation of Epithelial Barrier Function Stella Alimperti

7:45 PM SGK1 Promotes Alternative Macrophage Polarization and Restrains Periodontal Inflammation Xiao Han

8:00 PM Porphyromonas gingivalis Pangeomics Identify Clade Structures Consistent with Clinical Phenotypes Katherine A. Innamorati

8:15 PM Loss of Microbiome Homeostasis is Prevented by Inflammation Resolution Ning Yu

MODERATOR: Ranhui Xi

8:30 PM Foxp3+ Cell Depletion Aggravates Periodontal Disease Carla Alvarez

8:45 PM Periodontitis is Modulated by Sex-Specific Expression and Maturation of IL1β Kevin M. Byrd

9:00 PM The Role of γδT cells in Periodontitis Associated with LAD-I Kajikawa Tetsuhiro

9:15 PM Adjourn

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Monday, July 26, 2021

LOCATION ARTHUR E. CORBY AUDITORIUM (B-13)

8:30 AM WELCOME REMARKS Welcome to Philadelphia and the Penn Periodontal Conference

AM SESSION 1: MICROBIOLOGY MODERATOR: Tom Van Dyke

8:40 AM Acquisition of the periodontal microbiota Ann Griffen

9:05 AM A Roadmap to the Biomarkers of Periodontics Progression: Are We There Yet? Flavia Teles

9:30 AM Oral microbiome geography: the site-specialist hypothesis Gary Borisy

9:55 AM Temporal dynamics of the oral microbiome during periodontal disease Jorge Frias-Lopez

10:20 AM Coffee Break and Informal Discussions

AM SESSION 2: MICROBIOLOGY MODERATOR: Tom Van Dyke

11:05 AM Oral microbial communities and the art of situational ethics Richard J. Lamont

11:30 AM Filifactor alocis – the friendly foe Hansel Fletcher

11:55 AM Quantifying the accuracy of models used to study P. gingivalis Marvin Whiteley

12:20 PM NADPH oxidase activation regulates clearance of apoptotic neutrophils Juhi Bagaitkar

12:45 PM The 5th Penn Periodontal Conference Group Photo (Fonseca Garden)

1:00 PM Lunch (on your own) and Informal Discussions

PM SESSION 1: INNATE IMMUNITY MODERATOR: Tom Van Dyke

2:00 PM Harnessing Nature’s Elements for Periodontal Health Esra Sahingur

2:25 PM Role of monocytes/macrophages in periodontal disease and type 2 diabetes Fatemeh (Flora) Momen-Heravi

2:50 PM Trained innate Immunity and inflammatory comorbidities George Hajishengallis

3:15 PM Coffee Break

PM SESSION 2: INNATE IMMUNITY MODERATOR: Tom Van Dyke

4:00 PM Local immune cell tailoring to the gingiva Joanne Konkel

4:25 PM Myeloid-derived suppressor cells in obesity-associated Periodontal Disease Keith Kirkwood

4:50 PM Oral Inflammation Mediated Priming of the Innate Immune System Michael Glogauer

5:15 PM Local delivery approaches to modulate the innate host response for the treatment of periodontitis Charles Sfeir

5:40 PM Adjourn

6:00 PM Evening Reception

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Tuesday, July 27, 2021

LOCATION ARTHUR E. CORBY AUDITORIUM (B-13)

8:30 AM KEYNOTE LECTURE Stem Cells

Ken Zaret

AM SESSION 1: IMMUNITY AND DISEASE SUSCEPTIBILITY MODERATOR: Jeff Ebersole

9:30 AM Understanding periodontitis susceptibility through the study of Mendelian DiseaseNiki Moutsopoulos

9:55 AM NF-kB plays a key role in maintaining homeostasisDana Graves

10:20 AM Immunosenescence (T cells), inflammation and autoimmunityInsoo Kang

10:45 AM DEL-1 Promotes Treg Responses During Inflammation Resolution of PeriodontitisXiaofei Li

11:10 AM Coffee Break and Informal Discussions

AM SESSION 2: PATHOGENIC MECHANISMS MODERATOR: Jeff Ebersole

11:55 AM

12:20 PM

12:45 PM

Effect of e-cigarettes on oral microbial-mucosal interactionsPurnima Kumar

Epigenetic Dysregulation of Mucosal EpitheliumBo Yang

Adjourn

AFTERNOON FREE TIME AND INFORMAL DISCUSSIONS

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Wednesday, July 28, 2021

LOCATION ARTHUR E. CORBY AUDITORIUM (B-13)

8:30 AM KEYNOTE LECTURE New Developments in Covid-19

Ronald Collman

AM SESSION 1: CLINICAL PERIODONTICS AND SYSTEMIC DISEASE MODERATOR: Martha Somerman

9:30 AM

9:55 AM

10:20 AM

10:45 AM

11:10 AM

Pro blems (and solutions) in clinical trials in the association between periodontitis and other non-communicable diseasesPraveen Sharma

Epigenetics in Periodontal Development and DiseaseTom Diekwisch

Heparan Sulfate Modulation of Inflammation and Bone Homeostasis Patricia Miguez

The Role of Scaffolds in Periodontal and Alveolar Ridge Regeneration Rodrigo Neiva

Coffee Break and Informal Discussions

AM SESSION 2: CLINICAL PERIODONTICS AND SYSTEMIC DISEASE MODERATOR: Martha Somerman

11:55 AM Impact of periodontitis on gastrointestinal diseasesNobuhiko “Nobu” Kamada

12:20 PM Oral P. gingivalis infection and the development of Alzheimer’s diseasePing Zhang

12:45 PM Is there a causative relation between periodontitis and systemic diseases?Jan Potempa

1:10 PM Lunch (on your own) and Informal Discussions

PM SESSION 1: NEW TECHNOLOGIES MODERATOR: Martha Somerman

2:15 PM Discovering mesenchymal cell hierarchy in bone: the power of single cell RNA-sequencing.Ling Qin

2:40 PM PET-CT Imaging in pre-clinical models of diseaseSean Carlin

3:05 PM Application of single cell ATAC-seqRenata Pellegrino Da Silva

3:30 PM Coffee Break and Informal Discussions

PM SESSION 2: REGENERATION MODERATOR: Martha Somerman

4:15 PM Regulators of Periodontal Mineralization: Human Disorders and Animal ModelsBrian Foster

4:40 PM Activation of Endogenous Stem Cells Promotes Autotherapy for Tissue RegenerationChider Chen

5:05 PM Oral fibroblast heterogeneity and its role in expedited wound healingKang Ko

5:30 PM Adjourn

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Wednesday, July 28, 2021

LOCATION ARTHUR E. CORBY AUDITORIUM

EVENING SESSION: VIRTUAL INTERNATIONAL SESSION I MODERATOR: TBD

7:00 PM P gingivalis and L rhamnosus regulate Th17/Treg balance by TLR4 and TLR2 respectively Yi Liu

7:25 PM New insight for genetic susceptibility of periodontitisQing Xian Luan

7:50 PM In Situ Periodontal Tissue EngineeringShaohua Ge

8:15 PM Adjourn

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Thursday, July 29, 2021

LOCATION ARTHUR E. CORBY AUDITORIUM (B-13)

AM SESSION 1: REGENERATION (MSC/BONE) MODERATOR: Jeff Ebersole

8:30 AM Junctional epithelial stem cells and their link to periodontitisXue Yuan

8:55 AM IFT20 governs skeletal stem cell fate by regulating glucose metabolismShuying (Sheri) Yang

9:20 AM Impact of chronic inflammation and endotoxin tolerance on osteoclastogenesisMegan Weivoda

9:45 AM Tendon-formed bone during growth and bone regenerationJerry Feng

10:10 AM Coffee Break and Informal Discussions

AM SESSION 2: VIRTUAL INTERNATIONAL SESSION II MODERATOR: Jeff Ebersole

10:55 AM The use of Hyaluronic Acid in Reconstructive Periodontal Surgery: From the Lab to the ClinicAnton Sculean

11:20 AM Tooth associated fibroblasts as cell model to understand basic periodontitis pathogenesisTeun de Vries

11:45 AM Postnatal epithelium-microbiota interactions shape oral mucosal homeostasisAvi-Hai Hovav

12:10 PM Citrullination may link autoimmunity and periodontitisShauna Culshaw

12:35 PM Lunch (on your own) and Informal Discussions

PM SESSION: POSTERS & BEVERAGES

1:30 PM Poster Session

EVENING

4:00 PM Tours of Penn Dental Medicine

5:00 PM Closing Remarks, Dean Mark S. Wolff

5:15 PM Gala Reception and Dinner

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