Test 1 Test 2 Test 3 Test 4 Test 5 Test 6

Sensitivity 2.5 10.5 76.1 60 88 87.2

Specificity 100 100 91 70 98.2 96.3

PPV 100 100 90.5 74.5 98.3 97.3

NPV 47 53 76.5 62.5 87.5 86.5

Performance Characteristics of Six Commercial IgM Tests Relative to the CDC IgM Capture EIA*

*Assay comparison study was an ARRA-funded project done in conjunction with the APHL Santa Clara County Public Health Department and Iowa State Hygienic Laboratory performed the testing.

2006 2007 2008 2009 2010 20110

100

200

300

400

500

600

IgM Tests rRT-PCR

Measles Specimens Referred to CDC for Confirmatory or Reference Testing – 2006 to 2011

National Center for Immunization and Respiratory Diseases

Division of Viral Diseases

• Measles was laboratory-confirmed in 48 (87%) cases

• 20 (42%) by detection of measles-specific IgM antibodies only

• 24 (50%) by detection of measles-specific IgM antibodies and measles virus RNA

• 4 (8%) by detection of measles virus RNA only

Laboratory Confirmed Measles Cases in USA: 2012

National Center for Immunization and Respiratory Diseases

Division of Viral Diseases

Laboratory Confirmed Measles Cases in the USA, 2013 with Laboratory Results Shared with CDC

• IgM only 32 (45%)

• IgM and PCR 26 (37%)

• PCR only 12 (17%)

• Total 70