telo-100--toplinesummary--11december2013

8/13/2019 TELO-100--ToplineSummary--11December2013

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LONGER TELOMERES FOR A LONGER HEALTHSPANTM

TELO-100: TOPLINE SUMMARY & OVERVIEW

I. FROM THE LEADING EXPERTS IN TELOMERE SCIENCE: BACKGROUND

The Nobel Prize in Physiology or Medicine 2009 is awarded jointly to Elizabeth H. Blackburn, CarolW. Greider, and Jack W. Szostak for the discovery of how chromosomes are protected by telomeresand the enzyme telomerase.If the telomeres are shortened, cells age. Conversely, if telomeraseactivity is high, telomere length is maintained, and cellular senescence is delayed.

--The Nobel Assembly, 5 October 2009

Telomere shortness links to common disease states: cancer, pulmonary fibrosis, cardiovasculardisease (including plaques, heart attacks), vascular dementia, degenerative conditions(osteoarthritis, osteoporosis), diabetes, general risk factors for chronic disease--obesity and insulinresistance.

Correct telomere maintenance is crucial.Elizabeth Blackburn, Nobel Lecture 2009 & J Imm. Meth., Jan. 31, 2010

Studies point to a causal relationship between telomere loss, cell aging, reduced tissueregeneration and loss of tissue structure and function. In support of this causal relationship,epidemiological studies show that short telomeres in humans are a risk factor for atherosclerosis,hypertension, cardiovascular disease,Alzheimers disease, infections, diabetes, fibrosis, metabolicsyndrome, cancer, and overall mortality,

--Calvin Harley, Bill Andrews, Maria Blasco, et. al., Rejuvenation Research, September 2010

The literature is, I would say, 95% certain or better that if we can find a way to lengthen telomeres,we can reverse aging. Bill Andrews, Interview on the [U.S.] Today Show, December 13, 2011

The most exciting possibility suggested by the study is that if we can lengthen peoples telomeres,they would live longer and healthier lives.

Richard Cawthon, The University of Utah School of Medicine, Institute of Human Genetics

Telomere Biosciences, LLC. David B. Cross, Founder & President

. www.TelomereBiosciences.com Cell: 917.370.7456; [email protected]
http://www.telomerebiosciences.com/mailto:[email protected]:[email protected]://www.telomerebiosciences.com/


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II. THE SCIENCE BEHIND TELO-100:

While some companies and products focus solely on telomerase activation, a wealth of research by

some of the worlds leading experts in Telomere Science and Aging, including Nobel laureates,

demonstrates conclusively that there are several key factors which lead to Telomere shortening, all

of which should be addressed to have the greatest positive impact on Telomere length, which is the

scientific and medical goal, including most importantly:

--Chronological Aging/Cell Division, in the Absence of the Telomere-Lengthening Enzyme,

Telomerase. With the important exceptions of Adult Stem Cells and Leukocytes (which express

Telomerase at high levels until they approach the point of replicative senescence), Telomeraseis

inactive in most human cells, but if 'activated,' can lengthen Telomeres. [RB Effros, 2011; C.

Weyand & J. Gorozny, 2010; C. Harley & B. Andrews, 2010]

--Oxidative Stress,which can Reduce Telomerase Activity by 50-70% and Double the Rate of

Telomere Shortening. [Harley/Andrews/Blasco 2010; EH Blackburn 2010; Kurz, 2004; T. von Zglinicki, 2002]

--Inflammation,which Increases the Rate of Telomere Shortening and Has a Major Impact on

Telomerase Activity. [EH Blackburn, 2011; S. Bekaert, 2007, A. Aviv, 2009]

--Inhibiting the InflammatoryCytokine TNF-alphacan actually Increase Telomerase Activity by

1.25 to 1.78-Fold [RB Effros, 2009 & 2011]

--Cortisol and Homocysteine, each ofwhichcan each Reduce Telomerase Activity by up to 50%,

and each increases the Rate of Telomere Shortening [EH Blackburn, 2011; RB Effros, 2008; J. Zhu,

2006; A. Aviv, 2008]

III. IDENTIFICATION OF MULTIPLE NATURAL PRODUCT TELOMERASE ACTIVATORS:

Shortened telomeres and consequent inability to maintain normal tissue function may underlie mostage-related disease. Telomerase has been repeatedly proposed as a uniquely effective intervention.Several effective telomerase activators have been identified.

--Michael Fossel, M.D., PhD, Telomerase & Human Disease,Rejuv. Research, Nov. 23, 2009

We decided to start screening [several] natural products for telomerase-inducing activity .TA-65, a transient telomerase inducer from Geron, was already on the market through TA Sciences,&we had tested it &proved that it worked. We ran the [product] screens and found a lot of hits.

--Bill Andrews, PhD., and CEO of Sierra Sciences, LLC., In terv iew wi th Bi l l Andrews, PhD.Rejuvenation Research, August 2011
http://telo.attentiondefinite.com/?product=telo-100http://telo.attentiondefinite.com/?product=telo-100


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5. Highly-Significant Reductions in Systolic and Diastolic Blood Pressure; in the

case of SBP, an apparent reversal of >30 years of increase in SBP. Using the

Framingham 10-year CVD event calculator, these reductions [in cholesterol and BP]

would cause a 25% reduction in 10 year risk for males.

-- This reversal of in f lammation along with in creased telomerase activat ion could

rescue presenescent endothelial cells and increase the productio n of nitr ic oxid e

which could reduce SBP.

6. Significant decreases in both Homocysteine and C-reactive protein (CRP), which

are signif icant markers of Inf lamm ationand are associated with arterial

dysfunction and cardiovascular disease risk.

--"It is likely that fo late and vitamin s B12 and B6 in thesupp lement packs played a

signif icant role in the decl ine in homo cysteine."

7. Significant decrease in Fasting Glucose [an apparent reversal of 11 years of mean

increase in fasting glucose] and also a significant decrease in Insulin, indicating also

an improvement in Insulin sensitivity.

-- "It is possible that the com bination of antioxidants and inc reased telomerase

activat ionimproved insulin sensitivity in our subjects."

-- Insulin resistance is a cardinal element of the metabolic syndrome & thought to be a

result of increased inf lamm ation which the PattonProtocol-1 might have reduced.

B. With an Excellent Safety Profile:

No new cases of cancer or cardiovascular disease were reported during the overall 260person-years of dosing, and this is statistically significant.[Calvin B. Harley, et.al., Sept.2010]

V. THE EXPERTS ON TELOMERE BIOSCIENCES AND TELO-100:

"There are 3 Telomerase inducers [activators] on the market; the first was TA-65, from TA Sciences;and the absolute newest is from Telomere Biosciences."

--World-renowned Telomere & Telomerase Expert Dr. Bill AndrewsPresentation, February 23, 2012

"Other companies are starting to form that target the science of lengthening telomeres. A company

that seems to hold particular promise is Telomere Biosciences. Their first nutritional supplementtargets all three major causes of telomere shortening: aging, oxidative stress, and inflammation."

--Jeffry S. Life, M.D., Ph.D., in his ground-breaking book &New York Times Bestseller, The Life Plan

"Telomere Biosciences is breaking exciting new ground in the application of the latest advances inTelomere Biology to Age Management medicine. In my professional opinion as an Age Managementresearcher and clinician, this is truly next generation Telomere Science and the next generation ofscientifically-supported Telomere products."

--Vincent C. Giampapa, M.D., FACS, Founding President of the American Board of Anti-AgingMedicine and Internationally-recognized Age Management Medicine Clinician and Researcher,

October 24, 2011


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VI. TELO-100: OVERVIEW:

The MISSION of Telomere Biosciences: Grounded in the latest research and knowledge in Telomere

Science, to develop the most advanced and efficacious Telomere-lengthening supplements available;

and to make them price-accessible not only to the wealthy, but to the millions of people who can benefit

from longer Telomeres for a longer Healthspan. [Consumer price: $149/month] .

TELO-100 is the First & Only Integrated Complex of 17 Pro-Telomere Nutritional Ingredients,

including Multiple Natural Telomerase-Activators, to Target All Major Causes of Telomere

Shortening:

Telomerase Oxidative# of Ingredients Targeting: Activators NO* TNF-alpha Homocysteine Cortisol Stress Inflammation

Competitive Telomerase

Activator: 1 -- -- -- -- -- --

TELO-100: 8 8 12 5 4 17 13

--All 17 ingredients in TELO-100 have multiple methods of action which positively impact Telomere length

*Nitric Oxide (NO) is a documented Telomerase activator [Geron Corp.]

The Beneficial Effects of TELO-100, based on the Latest Research in Telomere Science andthe Scientific Literature of its Ingredients:[See Research Section for All Supporting Scientific References]

A. Telomere-Lengthening Benefits:

By uniquely targeting all major causes of Telomere shortening, TELO-100 is formulated to:

1. Help Maintain Existing Telomere Lengthand Slow the Rate of Telomere Shortening, to HelpPreserve the Functional Lifespan of Cells

2. Help Maintain Existing Levels of Telomerase Activity, especially in Adult Stem Cells &

Leukocytes, to Help Preserve Telomere Length, Replicative Capacity, and Functionalityin these Critical Cell Types

3. Activate the Enzyme Telomerase, through Multiple Natural Telomerase-ActivatingCompounds, to Help Lengthen Telomeres and to Promote an Increase in Cellular Lifespan

B. Other Important Health Maintenance Benefits:

1. Help Maintain & Support Immune System Health2. Help Maintain & Support Cardiovascular Health3. Help Maintain & Support Bone Health4. Help Maintain & Support Metabolic Health and Biomarkers

5. Help Maintain & Support the Health and Appearance of the Skin6. Help Maintain & Support Mitochondrial Health7. Help Maintain & Support Adult Stem Cell Health

Who Can Benefit from TELO-100?: TELO-100 is recommended for those 40-90+ years of age,most of whose Telomeres have begun to significantly shorten. One of the great dynamics ofTelomere Science is that the enzyme "Telomerasepreferentially lengthens the shortest telomeres"*[first], which means: since those who are 70, 80, or 90 on average have shorter Telomeres thansomeone who is 40 or 50, they can stand to benefit from a Telomere-lengthening nutraceutical justas much, perhaps even more, than the 40 or 50 year old.

[*Source: C. Harley & B. Andrews, 2010; C. Greider 2001]

telo-100--toplinesummary--11december2013

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