Technology Day

Innovations Applied in Omics & Translational Research

Date: 24 July 2017 Time: 08:30 - 17:30 Venue: Creation Theatrette, Matrix building, Level 4, 30 Biopolis Street, Singapore 138671

We would like to invite you to BTI - Waters Technology Day 2017. At this event, you will have the opportunity to discover the latest innovative technologies in Separations and Mass Spectrometry for applications in omics and translational research.

We are honoured to have onboard with us our keynote speaker, Professor Pauline M. Rudd BSc, LRIC, FISSR, MA (Oxon), PhD, head of GlycoScience Research Group at the National Institute for Bioprocessing Research and Training (NIBRT), Dublin, Ireland and visiting professor to the Bioprocessing Technology Institute at A*STAR, Singapore.

Alongside Professor Pauline M. Rudd, we also have with with us various industry experts to shed light on multi-omics approaches to translation research.

Agenda

Prof. Pauline M. Rudd BSc, LRIC, MA (Oxon), PhD is the Adjunct Professor of Glycobiology at University College, Dublin. She heads the GlycoSciences Research Group at the National Institute for BioProcessing Research and Training in Ireland (NIBRT). She has many links with academic groups, regulators and pharmaceutical companies across the world because GlycoScience is a major area of specialised expertise required to probe the pathways in many diseases and to ensure the safety and efficacy of biotherapeutic drugs, such as monoclonal antibodies for cancer and autoimmune disorders.

Professor Rudd obtained a BSc in Chemistry at the University of London and a PhD in Glycobiology at the Open University, UK. She was a Founding Scientist of Wessex Biochemicals (later Sigma London), Visiting Research Associate at The Scripps Research Institute, CA, Visiting Professor of Biochemistry at Shanghai Medical University PRC, Visiting Scientist at Ben Gurion University of the Negev, Israel and Erskine Visiting Fellow, Canterbury University, Christchurch, New Zealand. She is a Fellow of the Royal Society of Medicine, London and a Visiting Professor at St. George's Hospital, London and an Adjunct Professor at North Eastern University, Boston, NUI Galway and Trinity College Dublin. She is a Visiting Investigator at the Bioprocessing Technology Institute (BTI), in A-Star, Singapore.

She has more than 250 scientific publications and has given over 300 lectures and seminars at international meetings. Her research has focussed on developing novel technologies and bioinformatics programmes to probe disease related glycosylation changes and systems biology, particularly in cancer and immunology. She has held seven FP7 grants with colleagues from many EU countries. In 2010 she was awarded the James Gregory Medal and an Agilent Thought Leader award and in 2012 she received a Waters Global Innovation award. In 2014 she was awarded an Honorary Doctorate at Sahlgrenska Academy in Gothenburg University, Sweden. Before moving her group to Dublin in 2006, Professor Rudd was a member of the Glycobiology Institute for 25 years. When she left she was a Senior Research Fellow and a University Reader in Glycobiology at Oxford University.

Prof. Pauline M. Rudd BSc, LRIC, MA (Oxon), PhD, National Institute for BioProcessing Research and Training (NIBRT) Ireland, Bioprocessing Technology Institute, A*STAR

Based in Singapore, Mark Ritchie formed a new team, to support Asia-Pacific in high complexity applications, building connections between chemists in different countries and supporting the implementation of new MS products.

Prior to his current role, Mark leads Waters Solution Centre with the charter to address analytical science challenges within South East Asia. This includes ensuring customer success through advanced analytical application development capabilities and training support, new technology demonstrations and facilitation of strategic collaborations with industry leaders in the region.

Mark started with Waters in Manchester where he worked on development projects which provided label free quantitation and MSE, both of which are now common offerings in Waters solutions. He then moved on to become the Proteomics and Biotherapeutics Business Development Manager and Mass Spectrometry Product Manager for Asia Pacific. In his 12 years with Waters, Mark has spent 8 years in Asia where he has worked with customers from Australia, China, Indonesia, Japan, Korea, Malaysia, Philippines, Singapore, Thailand and Vietnam. Prior to Waters, Mark worked as a research biochemist with LC-MS.

Mark has worked on projects across multiple disciplines. These include the characterisation of the Prion protein to help understand the role of post translational modification and structure in the role pf pathogenicity, disease detection during the 2001 Foot and Mouth Disease emergency in the UK. Although he specializes in proteomics and biomolecules, Mark’s success in running a multidisciplinary applications research and development group has formed the foundation for the establishment of Waters Solution Centre in Singapore.

Originally trained as a biotechnologist, Mark specialised in analytical science after he graduated from his MSc in Instrumentation and Analytical Science from UMIST, Manchester.

Mark RitchieSenior Manager, Applications Specialists Team Waters APAC

Priya JayaramanPrincipal Product Manager for Chemistry / ConsumablesWaters Corporation

Priya is a Principal Product Manager for Bioseparations columns at Waters, Inc. where she is focused on driving the development and commercialization of market-leading reagents and chromatography-based technologies for the separation, purification and characterization of biological molecules.

Priya has over 10 years of experience in the bio-pharmaceutical industry supporting large molecule development across Research, Manufacturing, Process/Analytical Development and Program Management.

Dr. Terry Nguyen-Khuong currently leads the glyco-analytical group within the Bioprocessing Research Institute within ASTAR, Singapore. His expertise revolves around the development and application of analytical tool sets; both new laboratory techniques and bio-informatic tools to biological processes, diseases and infection to understand the importance of glyco-conjugates as biomarkers, therapeutics and in bioprocessing.

Terry obtained his B.Biotech (Adv) (Hons)at the University of Wollongong and PhD in proteomics at UNSW, Australia. After completing a post-doctoral fellowship in glyco-analytics lab of Professor Nicolle Packer, he spent a year at the ANZAC Research Institute before joining the Max Planck Institute for the Dynamics of Complex Technical Systems in Magdeburg as an experienced researcher as part of the EU funded HTP GlycoMet consortium. His work ranges from the first comprehensive characterization of human tear glycans and its role in diabetes to work complementing the analysis of glycosylation with bioprocessing engineering efforts to improve influenza vaccine production.

Terry Nguyen-KhuongAssociate Staff Scientist, Bioprocessing Technology Institute, A*STAR, Singapore

Lim Xin XiangPh. D Student, National University of Singapore, Department of Biological Sciences

Xin Xiang is a fourth year Ph. D student from the department of biological sciences, NUS. Under the supervisor of A/P Ganesh S. Anand, he monitored the dynamics of whole virus particles with hydrogen/deuterium exchange mass spectrometry. He is particularly interested in capturing the dynamics of the Dengue virus, the most prevalent arthopod-borne virus in Singapore, as understanding its structural dynamics in solution will potential offer important insights into its serotype-specific interactions with human host antibodies. HDXMS analysis of whole DENV particles importantly uncovered differential modes of serotype-specific expansion triggered by the increases in temperature accompanying mosquito to human transmission. Mapping the epitopes and paratopes of antibody-DENV complexes by HDXMS further identified the different modes of antibody interactions that is coupled to the structural dynamics of DENV2 and has allowed a delineation of the antibody heavy chain and light chain contributions that are associated with DENV neutralization.

Wang HanSenior Applications ConsultantWaters Pacific

Wang Han is the Senior Applications Consultant at Waters Pacific, providing application guidance and support to regional customers and distributors in South Asia. She has over 9 years of experience with mass spectrometry and proteomics, as well as diverse research experience in analytical biochemistry and molecular biology since her Ph.D. studies. Her current interests are in mass spectrometry-based Omics, including metabolomics and lipidomics, where these technologies are being adapted and applied to other system-wide studies in pharmaceutical research and food sciences. She holds a B.Sc. (Hons.) degree in life sciences from National University of Singapore, and a Ph.D. degree in biological sciences from Nanyang Technological University. Both degrees were sponsored by highly selective scholarship awards.

Lian Yee Yip is a Research Scientist in the Metabolomics group in the Bioprocessing Technology Institute (BTI) and a registered pharmacist under the Singapore Pharmacy Council. She received her B.Sc. (Pharmacy) (1st Class Hons) in 2009 and Ph.D. in 2015 from the National University of Singapore as a recipient of the President’s Graduate Fellowship.In collaboration with GlaxoSmithKline, Lian Yee explored the influence of the interaction between the host and gut microbiota in drug disposition and toxicity during her doctoral studies under the mentorship of A/Prof Eric Chun Yong Chan. Her work has been recognized internationally by the International Society for the Study of Xenobiotics (ISSX) (first prize, pre-doctoral poster competition category, San Francisco, 2014), and in Singapore as well (poster and presentation awards, 2013–2014).

Lian Yee is passionately involved in metabolomics research with specific focus on (1) host-gut microbiota interaction in disease, pharmacology and toxicology, (2) identification of metabolic bottlenecks in bioprocessing and cancer and (3) discovery of disease-related metabolic biomarkers.

Dr. Yip Lian Yee Research Scientist, Metabolomics, Bioprocessing Technology Institute Singapore

Alley started working in Waters in 2005 as UPLC specialist. Before joining Waters, she have worked for proteomics research lab in Samsung Biomedical Research Institute. She has B.S. and M.S. of Biotechnology (Plant cell culture and Purification) from A-Jou University. Application expertise in natural products, proteomics and biopharmaceutical, and solution expertise in UPLC, Quad and TOF.

During 11 years in Waters, she worked a MS specialist, MS marketing, Customer Success, Pharm Business Development and Sales manager.

Alley BanAsia Pacific Market Development Manager, Consumable Group Waters Korea Ltd

Vijay a drug discovery scientist working in DMPK since 2004, worked in neuroscience and anti-cancer programs. Previously worked for GSK-NPDPU, Biopolis Singapore, where he was in vivo lead and program rep. Currently working in Biological Resource Center as a DMPK head. He is a Pharmacy graduate having specialize in pharmacology and PhD in Drug-drug interactions.

Dr. Vijay SaradhiDMPK Head, Biological Resource Center, Singapore