tablets evalution
TRANSCRIPT
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PRESENTED TO PRESENTED BY
Dr. INDU SINGH GOVIND YADAV
Babasaheb Bhimrao Ambedkar University
Lucknow (Department of pharmaceutical
science)
A PRESENTATION ON Evaluation of Tablets
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INTRODUCTION
EVALUATION OF TABLET Non-official Tests:
1) General appearance I) Organoleptic property II) Size & Shape 2) Hardness 3) Friability Official tests: 1) Weight Variation 2) Content uniformity 3) Dissolution 4) Disintegration
CONTENTS
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INTRODUCTION Tablets:- Tablets are the solid unit dosage forms containing a medicament or mixture of medicament & excipients compressed or moulded into solid .
TYPE OF TABLETS :- I) Compressed tablets Ex: Coated & Uncoated tablets. II) Molded tablets Ex: Dispensing & Hypodermic tablets.
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Evaluation of Tablets Non-official Tests: 1) General appearance I) Organoleptic property II) Size & Shape 2) Hardness 3) Friability Official tests: 1) Weight Variation 2) Content uniformity 3) Dissolution 4) Disintegration
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1)GENERAL APPEARANCE: The general appearance of a tablet, its visual identity and overall “elegance” is essential for consumer acceptance, for control of lot-to-lot uniformity
Appearance of a tablet involved the measurements of a tablet’s:-
Size Shape Colour Odour Taste Surface texture
Non- official tests:
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Many pharmaceutical tablets use color as a vital means of rapid identification and consumer acceptance
The color of a product must be uniform within a single tablets
I) ORGANOLEPTIC PROPERTIES
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II) SIZE & SHAPE
Caliper scale
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Tablets require a certain amount of strength, or hardness and resistance to friability, to withstand mechanical shocks of handling in manufacture, packing and shipping
Hardness thus sometimes termed the tablet crushing strength
Tablet hardness tester are:- Monsanto tester Pfizer tester Strong-cobb tester Erweka tester Scleuniger tester
2) HARDNESS
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3)FRIABILITY The friability test is official in USP but not in BP
and IP
Friability tester is known as the Roche friabilator
Tablet hardness is not an absolute indicator
of strength since some formulations,when
compressed into very hard tablets
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PROCEDURE:-
Roche friabilator
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The weight of the tablet being made is
routinely measured to help ensure that a tablet
contains the proper amount of drug
As per indian pharmacopoeia (IP)
weight 20 tablets selected at random and
determine the average weight
1) Weight Variation
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Not more than 2 of the individual weights
deviate from the average weight by more than
the percentage deviation shown in the table
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The potency of tablets is expressed in the
terms of grams, milligrams, or micrograms of
drug per tablet and is given as the label
strength of the product Determine the amount of active ingredient by the
method in the Assay;
The result lies within the range for the content of
active ingredient stated in the monograph
2) Content uniformity
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This test is applicable to tablets that contain
less than 10mg or less than 10% w/w of the
active ingredient
It is not applicable to tablets containing
multivitamin and trace element
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Ten tablets are taken at random, there
content of active ingredient is determine in
each of 10 tablets and the average value is
calculated
The sample passes the test is not more than one of
the individual value is the out side the limit of 85
to 115% of the average value
As per IP:-
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If two or three of the individual tablets are
outside limits 85 to 115% of the average value
and the none is the outside the limit 75 to 125%
The test is repeated using another 20 tablets
And none is outside the limit 75 to 125% of the
average value
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In the total sample of 30 tablets
Not more than three of the individual values
are outsides the limit 85 to 115% and none is
outside the limits 75 to 125% of the average
value
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3) DISSOLUTION
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Dissolution test apparatus
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4) DISINTEGRATION
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pharmacopoeia
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References Indian pharmacopoeia J. Swarbrick and J.C. Boylan, Eds , Encyclopedia of pharmaceutical technology vol 12 lachmanl, lieberman h.a. ‘the theory and practice of industrial pharmacy
Banker gs & Rhodes c.t., ‘Modern pharmaceutics’
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Thank You