Table of TCGA Cancer Codes  TCGA code

Cancer type Number*

ACC Adrenocortical carcinoma 90 BLCA Bladder urothelial carcinoma 396 BRCA Breast invasive carcinoma 988 CESC Cervical squamous cell carcinoma and endocervical

adenocarcinoma 194

CHOL Cholangiocarcinoma (bile duct) 35 COAD Colon adenocarcinoma 367 DLBC Lymphoid neoplasm diffuse large B−cell lymphoma 48 ESCA Esophageal carcinoma 185 GBM Glioblastoma multiforme 290 HNSC Head and neck squamous cell carcinoma 513 KICH Kidney chromophobe 66 KIRC Kidney renal clear cell carcinoma 451 KIRP Kidney renal papillary cell carcinoma 282 LAML Acute myeloid leukemia 197 LGG Brain lower grade glioma 533 LIHC Liver hepatocellular carcinoma 373 LUAD Lung adenocarcinoma 546 LUSC Lung squamous cell carcinoma 178 OV Ovarian serous cystadenocarcinoma 469 PAAD Pancreatic adenocarcinoma 185 PCPG Pheochromocytoma and paraganglioma (adrenal gland) 184 PRAD Prostate adenocarcinoma 499 READ Rectum adenocarcinoma 122 SARC Sarcoma 247 SKCM Skin cutaneous melanoma 371 STAD Stomach adenocarcinoma 395 TGCT Testicular germ cell tumors 155 THCA Thyroid carcinoma 504 THYM Thymoma 123 UCEC Uterine corpus endometrial carcinoma 248 UCS Uterine carcinosarcoma 57 UVM Uveal melanoma 8  *Number  of  samples  with  mutation  data  

HM

TEV

168f

s

R27

3C

T125

T

E56

*

Y23

4C

C27

5S

R33

5fs

E33

9fs

R33

7H

V17

3L

K13

2N

E33

9*

C13

5Y

ER

CS

D18

0del

P27

fs

R21

3*

V73

fs

TP53 mutant alleles in adrenocortical carcinoma (N=90)0.

00.

20.

40.

60.

81.

0

NbrSamples=90 Mutant Samples=18 Total Mutations=17

HM

TEV

168

R27

3

T125

E56

Y23

4

C27

5

R33

5

R33

7

V17

3

K13

2

C13

5

ER

CS

D18

0del

P27

R21

3

V73

E33

9

TP53 mutant positions in adrenocortical carcinoma (N=90) 0.

00.

51.

01.

52.

0

NbrSamples=90 Mutant Samples=18 Total Mutations=17

D25

9VA

161T

C12

4fs

G24

5VH

214R

E28

7*L2

57Q

R15

8HE

271Q

E29

4*R

175H

A15

9VR

282W

R28

0KK

132N

E33

6*R

248W

Q19

2*R

273C

S24

1FE

271K

Q33

1*R

280T

E28

5KR

248Q

TP53 mutant alleles in bladder urothelial carcinoma (N=396), top 25 0

510

15

NbrSamples=396 Mutant Samples=198 Total Mutations=226(115 not shown)

G24

4H

214

L257

R15

8E

294

E20

4R

175

D25

9P

151

P27

8R

282

K13

2E

336

A15

9Q

192

A16

1E

287

S24

1G

245

Q33

1R

273

E27

1E

285

R28

0R

248

TP53 mutant positions in bladder urothelial carcinoma (N=396), top 250

510

1520

NbrSamples=396 Mutant Samples=198 Total Mutations=226 (88 not shown)

C23

8FQ

331*

G26

6EH

179R

C14

1YG

245D

R30

6*R

110f

sE

285K

V21

6MR

273C

R20

9fs

L194

RG

108f

sY

220C

S24

1fs

I195

TC

176F

R24

8WR

342*

H19

3RR

213*

R19

6*R

273H

R17

5H

TP53 mutant alleles in breast invasive carcinoma (N=988), top 250

510

15

NbrSamples=988 Mutant Samples=305 Total Mutations=288(158 not shown)

E28

5V

216

C13

5R

280

C23

8R

209

C14

1D

281

V17

3E

286

G10

8K

132

I195

H17

9L1

94S

241

R24

8C

176

R21

3Y

220

R19

6R

342

H19

3R

273

R17

5

TP53 mutant positions in breast invasive carcinoma (N=988), top 250

510

15

NbrSamples=988 Mutant Samples=305 Total Mutations=288 (128 not shown)

S37

6C

S18

3*

R33

7H

K13

2N

E27

1K

L194

F

K31

9N

E28

7D

R28

0K

C23

8F

E28

5K

TP53 mutant alleles in cervical squamous cell carcinoma and endocervical adenocarcinoma (N=194)0.

00.

51.

01.

52.

0

NbrSamples=194 Mutant Samples=9 Total Mutations=12

S37

6

S18

3

R33

7

K13

2

E27

1

L194

K31

9

E28

7

R28

0

C23

8

E28

5

TP53 mutant positions in cervical squamous cell carcinoma and endocervical adenocarcinoma (N=194)0.

00.

51.

01.

52.

0

NbrSamples=194 Mutant Samples=9 Total Mutations=12

R24

8W

S24

1F

C14

1R

Y23

4fs

MC

NS

SC

M23

7fs

C12

4Y

TP53 mutant alleles in cholangiocarcinoma (N=35)0.

00.

20.

40.

60.

81.

0

NbrSamples=35 Mutant Samples=5 Total Mutations=6

R24

8

S24

1

C14

1

Y23

4

MC

NS

SC

M23

7

C12

4

TP53 mutant positions in cholangiocarcinoma (N=35)0.

00.

20.

40.

60.

81.

0

NbrSamples=35 Mutant Samples=5 Total Mutations=6

G18

7GG

266V

W91

*A

159P

S31

5PH

214R

D18

6GS

95P

Y22

0CC

135Y

R17

5CY

205C

S22

7PR

342*

R30

6*G

245S

T125

TR

196*

R27

3CR

273H

R21

3*R

248W

R24

8QR

282W

R17

5H

TP53 mutant alleles in colon adenocarcinoma (N=367), top 250

510

1520

25

NbrSamples=367 Mutant Samples=233 Total Mutations=328(193 not shown)

A15

9P

278

S22

7R

158

R33

7R

342

G26

6F1

13E

349

R26

7C

135

M23

7F1

09R

306

C17

6G

244

K13

2R

196

G24

5T1

25R

282

R21

3R

273

R24

8R

175

TP53 mutant positions in colon adenocarcinoma (N=367), top 250

510

1520

25

NbrSamples=367 Mutant Samples=233 Total Mutations=328 (162 not shown)

H19

3RF1

09S

V27

4LC

176F

P12

8fs

C27

5FE

198*

G24

5SI2

55de

lR

175G

E29

4*P

278A

V27

2MR

196*

R30

6*R

342*

C13

5FR

213*

R28

2WY

220C

R27

3CR

273H

R24

8WR

248Q

R17

5H

TP53 mutant alleles in esophageal carcinoma (N=185), top 250

24

68

NbrSamples=185 Mutant Samples=153 Total Mutations=164(82 not shown)

E19

8S

241

I255

del

V27

4R

110

H17

9R

158

E29

4C

229

I195

V27

2R

196

C17

6C

275

R30

6G

245

R34

2R

213

P27

8R

282

Y22

0C

135

R17

5R

273

R24

8

TP53 mutant positions in esophageal carcinoma (N=185), top 250

24

68

1012

14

NbrSamples=185 Mutant Samples=153 Total Mutations=164 (63 not shown)

M24

6RR

213Q

R24

9TP

152S

R34

2*R

156C

G24

4SQ

375K

A13

8TR

248L

V21

6MH

179R

T155

NC

238F

C23

8YY

234C

R15

8HG

245S

Y22

0CR

248W

R19

6*R

282W

R27

3HR

175H

R24

8Q

TP53 mutant alleles in glioblastoma multiforme (N=290), top 250

12

34

56

NbrSamples=290 Mutant Samples=84 Total Mutations=96(40 not shown)

R21

3P

152

R34

2R

156

G24

4Q

375

A13

8V

216

G26

6I1

95T1

55L1

30Y

234

R24

9R

158

G24

5D

281

Y22

0H

179

R19

6R

282

C23

8R

273

R17

5R

248

TP53 mutant positions in glioblastoma multiforme (N=290), top 250

24

68

10

NbrSamples=290 Mutant Samples=84 Total Mutations=96 (29 not shown)

R28

3PR

249S

G26

6EQ

192*

Y23

6CR

337C

R11

0LH

193L

T125

TV

157F

H17

9RP

278S

Y16

3CR

273C

E29

8*R

306*

R19

6*Y

220C

G24

5SR

248W

R27

3HR

213*

R28

2WR

175H

R24

8Q

TP53 mutant alleles in head and neck squamous cell carcinoma (N=513), top 250

24

68

1012

NbrSamples=513 Mutant Samples=367 Total Mutations=412(257 not shown)

Y23

6V

173

C17

6R

337

R28

3P

278

R11

0T1

25R

280

E29

8V

157

Q33

1R

306

G26

6Y

163

Y22

0H

193

R19

6R

282

R17

5R

213

H17

9G

245

R27

3R

248

TP53 mutant positions in head and neck squamous cell carcinoma (N=513), top 250

510

1520

NbrSamples=513 Mutant Samples=367 Total Mutations=412 (208 not shown)

Y22

0CP

190L

C22

9*Y

205C

T125

TA

159P

S24

1FC

275Y

R28

2WK

292*

H17

8QN

239D

R33

7HC

176F

R19

6*C

141W

F338

IR

267W

P25

0LP

27fs

M24

6IH

214L

R21

3*

TP53 mutant alleles in kidney chromophobe (N=66)0.

00.

51.

01.

52.

02.

53.

0

NbrSamples=66 Mutant Samples=22 Total Mutations=25

Y22

0P

190

C22

9Y

205

T125

A15

9S

241

C27

5R

282

K29

2H

178

N23

9R

337

C17

6R

196

C14

1F3

38R

267

P25

0P

27M

246

H21

4R

213

TP53 mutant positions in kidney chromophobe (N=66)0.

00.

51.

01.

52.

02.

53.

0

NbrSamples=66 Mutant Samples=22 Total Mutations=25

G24

5D

H17

8fs

R21

3Q

R21

3*

H19

3Y

K35

1N

D28

1Y

N23

9S

S24

1C

V27

2M

S36

2fs

V73

fs

TP53 mutant alleles in kidney renal clear cell carcinoma (N=451)0.

00.

51.

01.

52.

02.

53.

0

NbrSamples=451 Mutant Samples=15 Total Mutations=15

G24

5

H17

8

H19

3

K35

1

D28

1

N23

9

S24

1

V27

2

S36

2

R21

3

V73

TP53 mutant positions in kidney renal clear cell carcinoma (N=451)0.

00.

51.

01.

52.

02.

53.

0

NbrSamples=451 Mutant Samples=15 Total Mutations=15

L111

P

I255

del

S24

1C

H19

3P

W91

*

Y22

0S

R34

2L

TP53 mutant alleles in kidney renal papillary cell carcinoma (N=282)0.

00.

20.

40.

60.

81.

0

NbrSamples=282 Mutant Samples=7 Total Mutations=7

L111

I255

del

S24

1

H19

3

W91

Y22

0

R34

2

TP53 mutant positions in kidney renal papillary cell carcinoma (N=282)0.

00.

20.

40.

60.

81.

0

NbrSamples=282 Mutant Samples=7 Total Mutations=7

C17

6Y

P22

3fs

R28

0G

T125

T

M40

fs

S21

5G

V17

3fs

H19

3Y

R33

7C

Q31

7*

C14

1W

R24

8Q

H17

9R

R34

2fs

I195

S

R27

3C

E28

6G

TP53 mutant alleles in acute myeloid leukemia (N=197)0.

00.

20.

40.

60.

81.

0

NbrSamples=197 Mutant Samples=16 Total Mutations=17

C17

6

P22

3

R28

0

T125

M40

S21

5

V17

3

H19

3

R33

7

Q31

7

C14

1

R24

8

H17

9

R34

2

I195

R27

3

E28

6

TP53 mutant positions in acute myeloid leukemia (N=197)0.

00.

20.

40.

60.

81.

0

NbrSamples=197 Mutant Samples=16 Total Mutations=17

F212

fsR

158G

C17

6FV

173A

C17

6YV

173M

W14

6*M

237I

M24

6VY

236C

S21

5GR

306*

R21

3*R

273L

F109

VR

196*

G24

5SR

282W

R24

8WH

179R

R17

5HR

248Q

Y22

0CR

273H

R27

3C

TP53 mutant alleles in brain lower grade glioma (N=533), top 250

1020

3040

5060

NbrSamples=533 Mutant Samples=264 Total Mutations=326(158 not shown)

V21

6S

215

I195

Q13

6Y

163

C27

7R

306

P15

2C

275

H19

3M

237

R26

7C

176

R21

3F1

09R

158

R28

2V

173

R19

6G

245

H17

9Y

220

R17

5R

248

R27

3

TP53 mutant positions in brain lower grade glioma (N=533), top 250

1020

3040

5060

70

NbrSamples=533 Mutant Samples=264 Total Mutations=326 (119 not shown)

G26

2fs

C27

5RR

156P

A27

6fs

K29

2*E

258K

V19

7LR

174W

C27

5YS

215I

E20

4*I3

32F

Y20

5SR

280K

Q19

2*N

263f

sC

277*

A16

1SR

158H

Y22

0CY

205C

V15

7FR

248Q

H19

3RR

249S

TP53 mutant alleles in liver hepatocellular carcinoma (N=373), top 250

24

68

10

NbrSamples=373 Mutant Samples=115 Total Mutations=109(60 not shown)

E25

8V

197

R17

4I3

32R

280

R21

3M

237

A27

6G

266

Q19

2N

263

C27

7Y

126

A16

1R

158

Y22

0E

204

V14

3S

215

C27

5Y

205

R24

8V

157

H19

3R

249

TP53 mutant positions in liver hepatocellular carcinoma (N=373), top 250

24

68

10

NbrSamples=373 Mutant Samples=115 Total Mutations=109 (48 not shown)

P15

2LY

205C

R17

5HR

196*

G15

4VE

198*

C27

5FY

220C

M23

7IR

337L

E29

8*V

157F

Q31

7*E

343*

Q19

2*R

248L

C24

2FR

249M

R11

0LR

213*

A15

9PG

245V

R15

8LR

273L

T125

T

TP53 mutant alleles in lung adenocarcinoma (N=546), top 250

24

68

NbrSamples=546 Mutant Samples=296 Total Mutations=290(200 not shown)

Q31

7E

343

Y23

6Q

192

C24

2G

154

R11

0R

213

Q33

1Q

144

Y16

3Y

205

R28

0A

159

E28

6H

193

V15

7R

248

D28

1R

337

T125

G24

5R

158

R27

3R

249

TP53 mutant positions in lung adenocarcinoma (N=546), top 250

24

68

10

NbrSamples=546 Mutant Samples=296 Total Mutations=290 (161 not shown)

R15

8GR

158f

sP

278R

C13

5WR

283P

H17

9LY

234C

E27

1KY

220C

R30

6*H

214R

E22

4EH

193L

R33

7LR

267P

G24

5VC

242F

E29

8*R

273L

T125

TY

163C

V15

7FR

175G

R21

3*R

158L

TP53 mutant alleles in lung squamous cell carcinoma (N=178), top 250

12

34

5

NbrSamples=178 Mutant Samples=145 Total Mutations=140(84 not shown)

R30

6H

214

L111

R33

7G

154

G24

4R

267

C24

2E

298

Y16

3V

157

Y23

4E

271

E22

4R

249

R17

5R

213

T125

R24

8P

278

H19

3G

245

H17

9R

273

R15

8

TP53 mutant positions in lung squamous cell carcinoma (N=178), top 250

24

68

NbrSamples=178 Mutant Samples=145 Total Mutations=140 (55 not shown)

V27

2MR

342*

R21

3*H

193Y

C27

5YR

196*

V21

6MC

176F

L194

RG

245S

H17

9RS

241F

H19

3RY

163C

G24

5DC

176Y

R28

2WR

248W

V15

7FR

273C

R24

8QY

220C

I195

TR

273H

R17

5H

TP53 mutant alleles in ovarian serous cystadenocarcinoma (N=469), top 250

24

68

1012

14

NbrSamples=469 Mutant Samples=391 Total Mutations=355(208 not shown)

V21

6M

237

V27

2R

342

C27

5D

281

C23

8G

266

Y23

4P

278

G24

4K

132

V15

7H

179

S24

1R

282

H19

3Y

163

Y22

0C

176

I195

G24

5R

175

R24

8R

273

TP53 mutant positions in ovarian serous cystadenocarcinoma (N=469), top 250

510

1520

NbrSamples=469 Mutant Samples=391 Total Mutations=355 (150 not shown)

R33

7CC

124f

sQ

52fs

T123

fsV

274F

R30

6*L1

94H

E28

6*C

176G

D18

6fs

G15

4VV

157F

N23

9DY

220C

H17

9YH

179R

R27

3HG

245S

R27

3CR

213*

R19

6*R

282W

R24

8QR

248W

R17

5H

TP53 mutant alleles in pancreatic adenocarcinoma (N=185), top 250

12

34

56

NbrSamples=185 Mutant Samples=120 Total Mutations=117(64 not shown)

T123

V27

4R

306

L194

E28

6C

176

D18

6G

154

V15

7N

239

G26

6Y

220

Y20

5P

151

C13

5C

124

S24

1R

213

R19

6H

179

G24

5R

282

R17

5R

273

R24

8

TP53 mutant positions in pancreatic adenocarcinoma (N=185), top 250

24

68

10

NbrSamples=185 Mutant Samples=120 Total Mutations=117 (50 not shown)

E27

1VA

PAP

SW

PL8

6fs

V17

3MA

74T

P82

LT2

56I

C13

5YQ

165f

sM

237I

H19

3NP

177R

R34

2*R

248W

R27

3CE

298*

VQ

L143

fsR

175H

R28

2WR

209f

sC

141G

Y16

3HG

245D

N23

9DG

245S

R24

8Q

TP53 mutant alleles in prostate adenocarcinoma (N=499), top 250

12

34

NbrSamples=499 Mutant Samples=61 Total Mutations=59(18 not shown)

C12

4R

181

E27

1A

PAP

SW

PL8

6V

173

A74

P82

T256

Q16

5M

237

P17

7R

342

R27

3E

298

VQ

L143

R17

5R

282

H19

3R

209

C14

1C

135

Y16

3N

239

R24

8G

245

TP53 mutant positions in prostate adenocarcinoma (N=499), top 250

12

34

56

7

NbrSamples=499 Mutant Samples=61 Total Mutations=59 (13 not shown)

P15

1SY

220F

GFR

LG10

8fs

C23

8YE

287*

Q13

6*R

337S

S95

PK

120E

C27

5YR

196*

G26

6VP

278T

V27

2GM

246V

E51

*G

245S

R30

6*R

213*

R27

3CR

248Q

R24

8WR

273H

R28

2WR

175H

TP53 mutant alleles in rectum adenocarcinoma (N=122), top 250

24

68

10

NbrSamples=122 Mutant Samples=91 Total Mutations=105(46 not shown)

E28

7Q

136

R33

7S

95K

120

C27

5R

196

G26

6V

272

M24

6E

51I2

51I1

95L1

94E

258

E28

6P

278

R30

6P

151

R21

3G

245

R28

2R

248

R17

5R

273

TP53 mutant positions in rectum adenocarcinoma (N=122), top 250

24

68

10

NbrSamples=122 Mutant Samples=91 Total Mutations=105 (36 not shown)

Y22

0CC

242S

E28

6KE

298*

Y22

0HC

275f

sY

163N

S24

1FH

179Q

D25

9VK

132E

G33

4fs

R24

8QF1

13de

lN

268Y

N26

8fs

AK

SV

TCT1

19de

lW

91*

C27

5YG

244S

R21

3*M

237I

C23

8YR

248W

R17

5H

TP53 mutant alleles in sarcoma (N=247), top 250

12

34

NbrSamples=247 Mutant Samples=85 Total Mutations=78(42 not shown)

F212

D28

1V

272

A18

9C

242

E28

6E

298

Y16

3S

241

D25

9K

132

G33

4F1

13de

lA

KS

VTC

T119

del

W91

G24

4M

237

C23

8H

179

N26

8C

275

R21

3Y

220

R24

8R

175

TP53 mutant positions in sarcoma (N=247), top 250

12

34

5

NbrSamples=247 Mutant Samples=85 Total Mutations=78 (34 not shown)

P15

1SP

151L

R21

3QD

48N

Y22

0CS

96fs

A27

6fs

P19

1LP

152L

P27

8SS

127F

R29

0CA

159V

H17

9YE

286K

P17

7LR

280K

R24

8WR

342*

F134

LP

27S

R19

6*Q

317*

S24

1FR

213*

TP53 mutant alleles in skin cutaneous melanoma (N=371), top 250

12

34

NbrSamples=371 Mutant Samples=56 Total Mutations=57(16 not shown)

G26

6D

48Y

220

S96

A27

6P

191

P15

2S

127

R29

0A

159

H17

9E

286

P17

7R

280

R24

8R

342

V14

3F1

34P

278

P15

1P

27R

196

Q31

7S

241

R21

3

TP53 mutant positions in skin cutaneous melanoma (N=371), top 250

12

34

5

NbrSamples=371 Mutant Samples=56 Total Mutations=57 (12 not shown)

G24

5SR

342*

R33

7CR

158H

P15

1TH

179R

R24

9SS

241f

sF2

70L

P34

fsV

173M

R19

6*E

286K

C17

6FV

272M

P15

3fs

M23

7IR

248W

Y22

0CR

213*

R24

8QR

282W

R27

3HR

273C

R17

5H

TP53 mutant alleles in stomach adenocarcinoma (N=395), top 250

24

68

10

NbrSamples=395 Mutant Samples=190 Total Mutations=190(94 not shown)

Y20

5R

249

S24

1T1

25P

34G

245

R19

6L1

30F2

70R

342

I195

V27

2P

72P

153

M23

7V

173

E28

6Y

220

H17

9R

213

C17

6R

282

R24

8R

175

R27

3

TP53 mutant positions in stomach adenocarcinoma (N=395), top 250

510

1520

NbrSamples=395 Mutant Samples=190 Total Mutations=190 (75 not shown)

C14

1YN

239S

S24

1PR

213Q

Q16

7fs

H17

9RQ

144*

R24

9SM

237K

S24

1CP

278T

V17

3LD

61fs

W14

6*S

241F

R15

8CS

240G

R17

5HG

244S

R21

3*Y

220C

R27

3CR

248Q

R27

3HR

248W

TP53 mutant alleles in uterine corpus endometrial carcinoma (N=248), top 250

12

34

5

NbrSamples=248 Mutant Samples=69 Total Mutations=73(28 not shown)

R28

2L2

52de

lD

281

C14

1Q

167

H17

9Q

144

M23

7V

173

D61

W14

6H

193

R15

8S

240

R17

5P

278

R24

9G

244

C23

8N

239

Y22

0R

213

S24

1R

273

R24

8

TP53 mutant positions in uterine corpus endometrial carcinoma (N=248), top 250

24

68

NbrSamples=248 Mutant Samples=69 Total Mutations=73 (16 not shown)

S18

3*V

216L

S12

1fs

R24

8WQ

100*

R28

0TR

273C

K13

2NE

349*

Y20

5NC

176f

sG

266V

I195

TR

249S

G24

5DR

181C

R21

3*H

193Y

C24

2SR

175H

H17

9RH

193R

S24

1YR

273H

R24

8Q

TP53 mutant alleles in uterine carcinosarcoma (N=57), top 250

12

34

56

NbrSamples=57 Mutant Samples=52 Total Mutations=52(15 not shown)

N23

9S

183

V21

6S

121

Q10

0R

280

K13

2E

349

Y20

5C

176

G26

6I1

95R

249

G24

5R

181

R21

3C

242

R17

5P

151

C23

8S

241

H17

9H

193

R27

3R

248

TP53 mutant positions in uterine carcinosarcoma (N=57), top 250

12

34

56

7

NbrSamples=57 Mutant Samples=52 Total Mutations=52 (9 not shown)

C17

6F

C23

8Y

G26

6V

V27

2M

V73

fs

W91

*

G24

5D

H19

3R

K13

2N

R30

6*

G24

5S

M23

7I

R34

2*

Y20

5C

H17

9R

R19

6*

R27

3H

R28

2W

R17

5H

T125

T

Y22

0C

R24

8Q

R21

3*

R24

8W

R27

3C

Number of cancer types where each TP53 mutation occurs, top 250

510

1520

1925 not shown

V17

3

C13

5

C14

1

I195

L194

M23

7

P15

1

C17

6

C27

5

H19

3

R28

2

R34

2

C23

8

G24

5

G26

6

H17

9

R33

7

S24

1

Y20

5

R17

5

T125

Y22

0

R21

3

R24

8

R27

3

Number of cancer types where each TP53 mutation position occurs, top 250

510

1520

1308 not shown

M23

7I

V27

2M

Y16

3C

S24

1F

E28

5K

R24

9S

I195

T

G24

5D

C17

6F

V15

7F

R34

2*

H19

3R

R30

6*

H17

9R

T125

T

G24

5S

R19

6*

Y22

0C

R21

3*

R28

2W

R24

8W

R27

3H

R24

8Q

R27

3C

R17

5H

Number of times each TP53 mutation occurs across all cancer types, top 250

2040

6080

100

120

2385 not shown

K13

2

E28

5

Y16

3

V15

7

C23

8

G26

6

R34

2

P27

8

I195

R24

9

R28

0

R15

8

T125

S24

1

C17

6

R19

6

H19

3

H17

9

Y22

0

R28

2

R21

3

G24

5

R17

5

R24

8

R27

3

Number of times each TP53 mutation position occurs across all cancer types, top 250

5010

015

020

0

1919 not shown

ACC

ACC

DLB

CLA

ML

LIH

CP

RA

DS

AR

CTH

YM

UC

SG

BM

LUS

CPA

AD

BLC

ALU

AD

UC

EC

RE

AD

ES

CA

BR

CA

HN

SC

CO

AD

STA

DO

VLG

G

Total number of TP53 R273 mutations in different cancer types0

1020

3040

5060

70

ACC

ACC

DLB

CLA

ML

LIH

CP

RA

DS

AR

CTH

YM

UC

SG

BM

LUS

CPA

AD

BLC

ALU

AD

UC

EC

RE

AD

ES

CA

BR

CA

HN

SC

CO

AD

STA

DO

VLG

G

Mutated allele breakdown for TP53 R273 mutations0

1020

3040

5060

70

R273CR273LR273SR273HR273P

ACC

ACC

DLB

CLA

ML

LIH

CP

RA

DS

AR

CTH

YM

UC

SG

BM

LUS

CPA

AD

BLC

ALU

AD

UC

EC

RE

AD

ES

CA

BR

CA

HN

SC

CO

AD

STA

DO

VLG

G All

0.0

0.2

0.4

0.6

0.8

1.0

Proportional view of allele breakdown of TP53 R273 mutations 1 1 1 1 1 1 1 1 4 5 6 6 8 9 9 10 11 15 15 17 20 23 76 242

R273CR273LR273SR273HR273P

CH

OL

DLB

CLA

ML

THY

MS

KC

MLI

HC

LUS

CS

AR

CLU

AD

PR

AD

BR

CA

UC

SR

EA

DU

CE

CG

BM

PAA

DS

TAD

ES

CA

LGG OV

CO

AD

HN

SC

BLC

A

Total number of TP53 R248 mutations in different cancer types0

510

1520

CH

OL

DLB

CLA

ML

THY

MS

KC

MLI

HC

LUS

CS

AR

CLU

AD

PR

AD

BR

CA

UC

SR

EA

DU

CE

CG

BM

PAA

DS

TAD

ES

CA

LGG OV

CO

AD

HN

SC

BLC

A

Mutated allele breakdown for TP53 R248 mutations0

510

1520

R248QR248PR248WR248GR248LR248fs

CH

OL

DLB

CLA

ML

THY

MS

KC

MLI

HC

LUS

CS

AR

CLU

AD

PR

AD

BR

CA

UC

SR

EA

DU

CE

CG

BM

PAA

DS

TAD

ES

CA

LGG OV

CO

AD

HN

SC

BLC

A All

0.0

0.2

0.4

0.6

0.8

1.0

Proportional view of allele breakdown of TP53 R248 mutations1 1 1 1 2 4 4 4 5 5 6 7 9 9 10 10 10 15 15 19 20 20 23 201

R248QR248PR248WR248GR248LR248fs

SK

CM

PR

AD

UC

EC

UC

S

BLC

A

LUA

D

LUS

C

GB

M

SA

RC

PAA

D

RE

AD

ES

CA

LGG

HN

SC

STA

D

OV

BR

CA

CO

AD

Total number of TP53 R175 mutations in different cancer types0

510

1520

25

SK

CM

PR

AD

UC

EC

UC

S

BLC

A

LUA

D

LUS

C

GB

M

SA

RC

PAA

D

RE

AD

ES

CA

LGG

HN

SC

STA

D

OV

BR

CA

CO

AD

Mutated allele breakdown for TP53 R175 mutations0

510

1520

25

R175HR175fsR175CR175GR175L

SK

CM

PR

AD

UC

EC

UC

S

BLC

A

LUA

D

LUS

C

GB

M

SA

RC

PAA

D

RE

AD

ES

CA

LGG

HN

SC

STA

D

OV

BR

CA

CO

AD All

0.0

0.2

0.4

0.6

0.8

1.0

Proportional view of allele breakdown of TP53 R175 mutations1 2 2 2 3 3 3 5 5 6 10 11 11 12 13 16 19 28 152

R175HR175fsR175CR175GR175L

KIR

C

LIH

C

UC

S

BR

CA

ES

CA

GB

M

RE

AD

STA

D

LUS

C

PAA

D

BLC

A

CO

AD

PR

AD

LGG

LUA

D

HN

SC

OV

Total number of TP53 G245 mutations in different cancer types0

24

68

1012

KIR

C

LIH

C

UC

S

BR

CA

ES

CA

GB

M

RE

AD

STA

D

LUS

C

PAA

D

BLC

A

CO

AD

PR

AD

LGG

LUA

D

HN

SC

OV

Mutated allele breakdown for TP53 G245 mutations0

24

68

1012

G245DG245SG245VG245CG245fsG245R

KIR

C

LIH

C

UC

S

BR

CA

ES

CA

GB

M

RE

AD

STA

D

LUS

C

PAA

D

BLC

A

CO

AD

PR

AD

LGG

LUA

D

HN

SC

OV All

Proportional view of allele breakdown of TP53 G245 mutations0.

00.

20.

40.

60.

81.

0 1 1 1 3 3 3 3 3 5 5 6 7 7 8 8 13 13 90

G245DG245SG245VG245CG245fsG245R

ACC

ACC

BLC

AG

BM

UC

SK

IRC

LIH

CK

ICH

OV

PAA

DR

EA

DS

AR

CU

CE

CE

SC

ALG

GLU

AD

LUS

CS

KC

MS

TAD

BR

CA

CO

AD

HN

SC

Total number of TP53 R213 mutations in different cancer types0

24

68

1012

ACC

ACC

BLC

AG

BM

UC

SK

IRC

LIH

CK

ICH

OV

PAA

DR

EA

DS

AR

CU

CE

CE

SC

ALG

GLU

AD

LUS

CS

KC

MS

TAD

BR

CA

CO

AD

HN

SC

Mutated allele breakdown for TP53 R213 mutations0

24

68

1012

R213*R213QR213LR213PR213G

ACC

ACC

BLC

AG

BM

UC

SK

IRC

LIH

CK

ICH

OV

PAA

DR

EA

DS

AR

CU

CE

CE

SC

ALG

GLU

AD

LUS

CS

KC

MS

TAD

BR

CA

CO

AD

HN

SC All

0.0

0.2

0.4

0.6

0.8

1.0

Proportional view of allele breakdown of TP53 R213 mutations1 1 1 1 1 2 2 3 3 3 3 3 3 4 4 4 4 5 5 7 11 12 83

R213*R213QR213LR213PR213G

CH

OL

ACC

ACC

.1D

LBC

LAM

LTH

YM

KIC

HK

IRC

LIH

CS

KC

MS

AR

CP

RA

DU

CS

LUS

CU

CE

CG

BM

LUA

DPA

AD

RE

AD

BLC

AE

SC

AB

RC

AS

TAD

HN

SC

OV

CO

AD

LGG

Positional breakdown of TP53 mutations across cancer types0

2040

6080

100

R273R248R175G245R213

CH

OL

ACC

ACC

.1D

LBC

LAM

LTH

YM

KIC

HK

IRC

LIH

CS

KC

MS

AR

CP

RA

DU

CS

LUS

CU

CE

CG

BM

LUA

DPA

AD

RE

AD

BLC

AE

SC

AB

RC

AS

TAD

HN

SC

OV

CO

AD

LGG All

Proportional position breakdown of TP53 mutations0.

00.

20.

40.

60.

81.

0 1 2 2 2 2 2 3 3 8 8 13 15 15 22 23 24 29 30 35 41 44 50 51 72 74 83 114

768