table of common herbs and supplements

42
Table of Common Herbs and Supplements

Upload: others

Post on 12-Feb-2022

3 views

Category:

Documents


0 download

TRANSCRIPT

Table of Common Herbs and Supplements

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Aca

i (ah

-sig

h-EE

)◆

◆B

erry

from

Sou

th a

nd

Cen

tral

Am

eric

a

Ant

i-can

cer

Ant

i-oxi

dant

Ant

i-inf

lam

mat

ory

No

scie

ntifi

c st

udie

s do

ne o

n us

e fo

r m

edic

al c

ondi

tion

s

Alle

rgic

to

acai

or

plan

ts in

pal

m fa

mily

May

aff

ect

MR

I res

ults

AD

Rs:

Hyp

erte

nsio

nG

I ble

edin

gU

lcer

s

Juic

e, c

apsu

le, p

owde

r,

tabl

ets

Wid

ely

used

, no

spec

ific

dosi

ng

Alo

e V

era

“bur

n pl

ant”

“l

ily o

f the

des

ert”

◆◆

Leav

es c

onta

in a

cle

ar g

el t

hat

can

be u

sed

topi

cally

◆◆

Gre

en p

art

of le

af t

hat

surr

ound

s

gel p

rodu

ces

juic

e or

dri

ed

subs

tanc

e (l

atex

) th

at c

an b

e

take

n or

ally

◆◆

Use

d ba

ck 6

000

year

s to

Eg

ypti

an t

imes

Scie

ntifi

c st

udie

s sh

ow b

enef

it

for

topi

cal g

el h

ealin

g bu

rns

and

abra

sion

s; h

owev

er, m

ay n

ot

wor

k fo

r de

ep s

urgi

cal w

ound

s or

ra

diat

ion

wou

nds

Laxa

tive

aff

ect

take

n or

ally

Inac

tiva

tes

HSV

2 vi

rus

Bac

teri

osta

tic

prop

erti

es

Con

tain

s st

erol

s w

ith

an

ti-in

flam

mat

ory

prop

erti

es

* Tox

icol

ogy

stud

y of

ora

l who

le le

af e

xtra

ct f

ound

ris

k of

car

cino

geni

city

in la

b an

imal

s* T

opic

al a

loe

has

no k

now

n si

de e

ffec

tsA

DR

s w

ith

oral

alo

e:Lo

wer

s bl

ood

suga

r by

sti

mul

atin

g in

sulin

Dia

rrhe

a/ab

d.cr

amps

Arr

hyth

mia

from

hyp

okal

emia

Con

tac

derm

atit

is, s

ting

ing,

sor

enes

sA

cute

hep

atit

is, r

enal

failu

re, n

ephr

itis

Abo

rtifa

cent

, may

↑ut

erin

e bl

eedi

ngA

void

in p

regn

ancy

and

lact

atio

nA

void

per

iope

rati

vely

; has

cau

sed

blee

ding

Top

ical

alo

e on

ly

Use

of

oral

alo

e no

t re

c-om

men

ded

due

to s

afet

y co

ncer

ns

Use

of

IM a

nd IV

alo

e ha

ve b

een

asso

ciat

ed

wit

h de

ath

Avo

id if

hx

of a

llerg

ies

to

any

mem

ber

of L

iliac

eae

fam

ily (

tulip

s, li

lies,

hya

-ci

nths

, oni

ons,

asp

arag

us,

and

garl

ic)

Ash

wag

anda

“w

itha

nia

som

nife

ra”

Use

s: A

dapt

ogen

Ant

i-art

hrit

is

Ant

i-agi

ng

Type

2 D

iabe

tes

Mel

litus

Hyp

erlip

idem

ia

Park

inso

n’s

dise

ase

* Do

not

use

in p

regn

ancy

: has

bee

n us

ed a

s ab

orti

face

ntA

DR

s:↓

bp↓

bs↑

WB

C↑

plat

elet

s↓

tes

tost

eron

e/FS

H le

vels

DR

UG

INT

ERA

CT

ION

S:A

lcoh

ol, s

edat

ives

, anx

ioly

tics↑

sed

atio

nA

void

wit

h di

uret

ics-↑

effe

cts

Ant

icoa

gula

nts ↑

blee

ding

Ant

idia

beti

c ag

ents

↑hy

pogl

ycem

iaA

ntih

yper

tens

ives

↑hy

pote

nsio

nTh

yroi

d ho

rmon

es-a

lter

eff

ect

In c

apsu

les,

tab

lets

, tea

Tabl

ets

are

stan

dard

ized

Dos

e: 1

-6 g

in c

apsu

le o

r te

a qd

Or

3-12

g in

com

bina

tion

w

ith

othe

r he

rbs

Pedi

atri

c do

sage

: (8-

12

year

s on

ly)

2g q

d fo

r no

>6

0 da

ys

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Asi

an G

inse

ng

“Kor

ean

gins

eng”

“C

hine

se g

inse

ng”

◆◆

Not

e: S

iber

ian

gins

eng

is n

ot

gins

eng

at a

ll

Use

s: a

dapt

ogen

, sta

min

a, m

enta

l an

d ph

ysic

al p

erfo

rman

ce

Hep

atit

is C

Men

opau

se

Erec

tile

dys

func

tion

Hyp

erte

nsio

n

Dia

bete

s m

ellit

us

Stud

ies:

may

low

er b

lood

glu

cose

; m

ay h

elp

imm

une

func

tion

NC

CA

M r

esea

rch

curr

entl

y in

ca

ncer

and

Alz

heim

er’s

dis

ease

↑T

cell

and

lym

phoc

yte

acti

vity

May

inhi

bit

RN

A t

ype

viru

ses

May

hav

e an

tiox

idan

t pr

oper

ties

* Ris

k al

lerg

ic r

eact

ions

* Not

rec

omm

ende

d in

pre

gnan

cy/l

acta

tion

due

to

horm

onal

and

tox

ic e

ffec

ts, t

erat

ogen

* ↑ r

isk

brea

st c

ance

r-st

imul

ates

bre

ast

canc

er c

ells

* avo

id in

ast

hma,

arr

hyth

mia

, HTN

, psy

chia

tric

dis

orde

r

* sto

p pr

e-op

erat

ivel

y du

e to

ble

edin

g ef

fect

AD

Rs:

H/A

GI d

istu

rban

ce, a

ppet

ite

chan

ges

Slee

p di

stur

banc

e

Arr

hyth

mia

Ane

mia

Stev

ens-

John

sons

Syn

drom

e

↑es

trog

enic

eff

ects

Men

stru

al c

hang

es, ↑

blee

ding

Mas

talg

ia, b

reas

t gr

owth

Man

ia in

bip

olar

dis

orde

r

DR

UG

INT

ERA

CT

ION

S:

anti

coag

ulan

ts↑

blee

ding

anti

diab

etic

age

nts ↑

or↓

bs

anti

hype

rten

sive

s-al

ter

effe

ct

anti

psyc

hoti

cs ↑

seda

tion

, ↑ef

fect

estr

ogen

↑ef

fect

seda

tive

s ↑

seda

tion

Roo

t is

dri

ed fo

r ta

blet

s,

caps

ules

, ext

ract

s, t

eas

Tabl

et a

nd c

apsu

le

stan

dard

ized

to

4 %

gi

nsen

osid

es (

acti

ve

ingr

edie

nt)

Shor

t te

rm u

se: u

p to

2

g/da

y Pa

nax

gins

eng

Long

-ter

m u

se: 1

g/d

ay

Pana

x gi

nsen

g

Not

e: g

inse

ng is

add

ed

to m

any

com

mer

cial

be

vera

ges

curr

entl

y

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Pan

ax G

inse

ng “

Am

eric

an g

inse

ng”

See

Asi

an G

inse

ng

Use

s: A

DH

D, c

hron

ic H

epat

itis

B,

CH

F, d

emen

tia,

CA

D, h

yper

lipid

emia

, m

enop

ausa

l sym

ptom

s, IT

P, M

RSA

, di

abet

ic r

enal

dis

ease

See

abov

eSe

e ab

ove

Ast

ralg

us “

milk

vet

ch”

◆◆

Trad

itio

nal C

hine

se M

edic

ine

for

imm

unit

y, c

ance

rs, a

nd h

epat

itis

◆◆

In le

gum

e fa

mily

◆◆

300

spec

ies

grow

in N

orth

Am

er-

ica;

som

e to

xic

to li

vest

ock

Und

er s

tudy

: pot

enti

al b

enef

its

for

imm

une

syst

em, l

iver

,hea

rt, a

nd

adju

ncti

ve c

ance

r th

erap

y

2005

Coc

hran

e st

udy:

som

e im

mun

e st

imul

atio

n an

d ↓

N/V

in c

olor

ecta

l ca

ncer

Ant

ioxi

dant

eff

ects

Use

d in

CA

D a

nd D

M

Use

d in

hep

atit

is, H

IV,

hepa

topr

otec

tion

Che

mot

hera

py s

ide

effe

cts

Men

tal p

erfo

rman

ce

Smok

ing

cess

atio

n

UR

I, bu

rns

* som

e as

trag

alus

spe

cies

, mos

tly

not

foun

d in

di

etar

y su

pple

men

ts u

sed,

mig

ht b

e to

xic.

Som

e sp

ecie

s to

xic

leve

ls o

f se

leni

um a

nd s

ome

cont

ain

neur

otox

in s

wai

nson

ine

whi

ch h

as c

ause

d “l

oco-

wee

d” p

oiso

ning

in a

nim

als.

Die

tary

sup

plem

ent

astr

algu

s is

gen

eral

ly c

onsi

dere

d sa

fe fo

r m

ost

adul

ts

DR

UG

INT

ERA

CT

ION

S

may

inte

ract

wit

h im

mun

e su

ppre

ssan

ts, s

uch

as

can

cer

drug

cyc

loph

osph

amid

e an

d or

gan

tran

spla

nt d

rugs

.

AD

Rs:

↓B

S,↓

HR

, ↓B

S

Dia

rrhe

a

Ble

edin

g: in

tera

cts

wit

h an

tico

agul

ants

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

Avo

id in

imm

une

diso

rder

s, t

rans

plan

ts,

blee

ding

dis

orde

rs

Roo

t us

ed in

tea

s, s

oups

, ca

psul

es, e

xtra

cts,

tin

ctur

e,

IM a

nd IV

No

spec

ific

dosi

ng

reco

mm

enda

tion

s

Mos

tly

used

as

drie

d ro

ot,

cons

ider

ed n

on-t

oxic

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Bilb

erry

“H

uckl

eber

ry”

“E

urop

ean

blue

berr

y”◆

◆R

elat

ed t

o bl

uebe

rry

◆◆

Ber

ries

or

drie

d le

aves

ar

e m

edic

inal

◆◆

Use

d fo

r 10

00 y

ears

in E

urop

ean

folk

med

icin

es, e

spec

ially

for

scur

vy

and

diar

rhea

Con

tain

s an

thoc

yano

side

s (t

ype

of fl

avin

oid)

:↑m

icro

circ

ulat

ion,

an

tiox

idan

t, p

late

let

inhi

bito

r,

anti

-infla

mm

ator

y,↓

capi

llary

fr

agili

ty, p

rese

rves

end

othe

lium

Ath

eros

cler

osis

Peri

pher

al v

ascu

lar

dise

ase

Dia

bete

s m

ellit

us

Pept

ic u

lcer

dis

ease

Dia

rrhe

a

Cat

arac

ts a

nd g

lauc

oma

Ret

inop

athy

4 st

udie

s sh

owed

no

bene

fit fo

r ni

ght

visi

on

1 st

udy

show

ed p

ossi

ble

anti

prol

if-er

ativ

e ef

fect

s on

col

on c

ance

r ce

lls

Not

eno

ugh

scie

ntifi

c ev

iden

ce fo

r ot

her

indi

cati

ons

AD

R:

↓B

P

↓ o

r↑ b

lood

sug

ar

Dia

rrhe

a, n

ause

a

Hep

atot

oxic

ity

Ble

edin

g

Dru

g in

tera

ctio

ns:

anti

coag

ulan

ts→↑

blee

ding

anti

diab

etic

age

nts-↑↓

blo

od s

ugar

anti

hype

rten

sive

s→↓

BP

estr

ogen

-may↓

abso

rpti

on

Avo

id in

alle

rgy

to b

lueb

erri

es o

r sa

me

fam

ily

of b

erri

es

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

In d

ried

leav

es, b

erri

es,

extr

act,

tin

ctur

e, c

apsu

les,

ta

blet

s

No

spec

ific

dosi

ng

reco

mm

enda

tion

s

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Bla

ck C

ohos

h “b

lack

sna

kero

ot”

“bug

bane

” “b

ugw

ort”

◆◆

Not

sam

e as

blu

e co

hosh

◆◆

Con

tain

s sa

licyl

ic a

cid

◆◆

Mem

ber

of b

utte

rcup

fam

ily◆

◆U

sed

in N

ativ

e A

mer

ican

and

A

mer

ican

folk

med

icin

e fo

r m

enop

ausa

l sx,

indu

ctio

n of

la

bor,

rhe

umat

ism

Men

opau

sal s

ympt

oms

m

ost

trad

itio

nal

Stud

y re

sult

s m

ixed

on

this

.◆

◆N

CC

AM

stu

dy—

faile

d to

rel

ieve

ni

ght

swea

ts a

nd h

ot fl

ashe

s◆

◆N

IH 2

008—

inad

equa

te s

uppo

rt

for

use

◆◆

Ger

man

E C

omm

issi

on—

appr

oved

fo

r m

enop

ausa

l sx,

not

>6

mon

ths

◆◆

Nor

th A

mer

ican

Men

opau

se

Soci

ety

(200

4) r

ecom

men

ds◆

◆In

suff

icie

nt s

tudi

es fo

r sa

fety

>6

mon

ths

or fo

r rh

eum

atis

m

* Uni

ted

Stat

es P

harm

acop

eia:

wom

en s

houl

d di

scon

tinu

e us

e of

bla

ck c

ohos

h an

d co

nsul

t a

heal

th c

are

prac

titi

oner

if t

hey

have

a li

ver

diso

rder

or

dev

elop

sym

ptom

s of

live

r tr

oubl

e, s

uch

as

abdo

min

al p

ain,

dar

k ur

ine,

or

jaun

dice

.

seve

ral c

ase

repo

rts

of h

epat

itis

and

live

r fa

ilure

; not

kn

own

if bl

ack

coho

sh w

as c

ause

Avo

id in

pre

gnan

cy/l

acta

tion

; can

indu

ce la

bor

AD

Rs:

Stom

ach

pain

,con

stip

atio

n

H/A

, ras

h, d

izzi

ness

Ble

edin

g, b

ruis

ing

↑ri

sk C

VA

Mas

talg

ia, u

teri

ne b

leed

ing

↑ri

sk h

orm

one-

asso

ciat

ed fe

mal

e ca

ncer

s

Hep

atot

oxic

ity

Dru

g In

tera

ctio

ns

CYP

450

2D

6 dr

ugs

Ant

icoa

gula

nt d

rugs

↑ b

leed

ing

from

sa

licyl

ate

ingr

edie

nt

Ant

ihyp

erte

nsiv

es-↓

BP

Hep

atot

oxic

dru

gs→

liver

failu

re

Che

mot

hera

peut

ic d

rugs

Tam

oxife

n, a

ntie

stro

gens

, HR

T, O

CP→

estr

ogen

ic

effe

ct

thyr

oid→

hype

rthy

roid

ism

Extr

act

from

dri

ed r

hizo

me

and

root

In c

aple

ts, c

apsu

les,

pow

-de

red

root

, dri

ed r

hizo

me,

te

a, t

inct

ure

OTC

: Bla

ck C

ohos

h as

Rem

ifem

in in

dos

age

20

mg

bid

Oth

er b

rand

s:

Men

opau

se S

uppo

rt

Estr

oven

(in

clud

es o

ther

in

gred

ient

s)

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

But

terb

ur “

Pet

adol

ex”

pa

tent

ed n

ame

◆◆

pere

nnia

l shr

ub◆

◆le

af, r

oot

and

rhiz

ome

used

for

extr

act

Ast

hma

Alle

rgic

rhi

niti

s

Mig

rain

e pr

ophy

laxi

s

smoo

th m

uscl

e re

laxa

nt

leuk

otri

ene

and

CO

X-2

inhi

bito

r

anti

chol

iner

gic

effe

ct p

ossi

ble

Stud

ies

show

as

muc

h ef

fect

iven

ess

as

anti

hist

amin

e fo

r al

lerg

ies

Som

e st

udie

s sh

ow e

ffec

tive

ness

for

mig

rain

e tr

eatm

ent

Con

flict

ing

resu

lts

on a

sthm

a

DA

NG

ER: N

AT

UR

AL

PR

OD

UC

T C

ON

TA

INS

PYR

RO

LIZI

DIN

E A

LKA

LOID

(PA

’S) →

CA

USE

LI

VER

DA

MA

GE

AN

D R

ISK

CA

RC

INO

GEN

ICIT

Y

* Onl

y bu

tter

bur

prod

ucts

tha

t ha

ve b

een

pr

oces

sed

to r

emov

e P

As

and

are

labe

led

or

cer

tifie

d as

PA

-fre

e sh

ould

be

used

.

Avo

id if

alle

rgic

to

ASt

erac

eae

fam

ily =

ragw

eed,

m

arig

old,

dai

sies

, chr

ysan

them

ums

Avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

Bel

chin

g, a

bd p

ain,

N/V

/D

Dep

ress

ion

Uri

nary

ret

enti

on

Ras

h, p

ruri

tus

Prur

itus

eye

s, a

sthm

a

drow

sine

ss

Dru

g In

tera

ctio

ns

Cal

cium

cha

nnel

blo

cker

s

Ant

icho

liner

gics

↑sx

Vas

odila

tors

(va

sodi

late

s)

Test

oste

rone↓

it

Chr

onot

rope

s an

d is

otro

pes→

nega

tive

act

ivit

y

Soft

gel,

pow

der,

tin

ctur

e,

extr

act,

cap

sule

Extr

act

is s

tand

ardi

zed

Alle

rgic

rhi

niti

s: P

etas

in

(Tes

alin

) 8m

g up

to

QID

Ast

hma:

Pet

afor

ce

50-1

50m

g bi

d-ti

d pr

n

Mig

rain

e pr

even

tion

: Pe

tado

lex

50-7

5mg

bid

up

to

4 m

onth

s

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Cat

’s C

law

◆◆

Cen

tral

and

Sou

th A

mer

ica

◆◆

Dat

es t

o us

e by

Inca

s

Stud

ies

show

pos

sibl

e be

nefit

in r

heu-

mat

oid

arth

riti

s an

d os

teoa

rthr

itis

In v

itro

stu

dy: p

ossi

ble

use

as

anti

vira

l, an

titu

mor

age

nt

imm

unos

tim

ulan

t

Ant

i-inf

lam

mat

ory

effe

ct

Enha

nces

DN

A r

epai

r

↑ph

agoc

ytos

is

Free

rad

ical

sca

veng

er

Poss

ible

res

earc

h on

Alz

heim

er’s

di

seas

e be

nefit

* som

e pr

epar

atio

ns f

rom

Per

u m

ay b

e co

ntam

inat

ed w

ith

fung

us, o

ther

her

bs,

aero

bes

and

be t

oxic

AD

Rs:

Seda

tion

↓B

P

↓es

trad

iol a

nd p

roge

ster

one

One

rep

ort

rena

l fai

lure

in S

LE p

atie

nt

Avo

id in

pre

gnan

cy/l

acta

tion

; tra

diti

onal

use

as

abo

rtifa

cent

Avo

id w

ith

hx a

utoi

mm

une

dise

ase,

hyp

oten

sion

, re

nal t

rans

plan

t, r

enal

dis

ease

, im

mun

osup

pres

sion

, bl

eedi

ng d

isor

ders

DR

UG

INT

ERA

CT

ION

S:

CYP

3A

4 ↑

leve

ls

anti

hype

rten

sive

s↓B

P

anti

arrh

ythm

ics:

↑ a

rrhy

thm

ias

anti

coag

ulan

ts:↑

blee

ding

ris

k

calc

ium

cha

nnel

blo

cker

s: ↑

effe

ct

imm

unos

uppr

essa

nts:↓

leve

ls

neph

roto

xic

drug

s: →

rena

l fai

lure

iron

:↓ab

sorp

tion

Cap

sule

, tab

let,

tin

ctur

e,

tea,

bar

k/le

aves

/roo

ts

in d

ried

, cut

or

po

wde

red

form

s

Gen

eral

use

: 250

-100

0mg

1-3

x/da

y

Free

ze d

ried

ext

ract

: 10

0mg/

day

Oth

er fo

rms

avai

labl

e

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Cha

mom

ile◆

◆G

erm

an c

ham

omile

is m

ore

com

mon

for

supp

lem

ents

Stud

ies:

◆◆

indi

cate

som

e be

nefit

for

gene

ral-

ized

anx

iety

dis

orde

r◆

◆be

nefit

for

infa

nt c

olic

, chi

ldre

n’s

diar

rhea

, GI u

pset

◆◆

bene

fit fo

r m

outh

ulc

ers

in r

adia

-ti

on o

r ch

emot

hera

py

Com

mon

use

s fo

r ra

diat

ion

skin

is

sues

, wou

nd h

ealin

g, a

nxie

ty

Ant

i-inf

lam

mat

ory

and

an

ti-s

pasm

odic

eff

ects

Seda

tive

eff

ects

may

be

from

bin

ding

to

ben

zodi

azep

ine

rece

ptor

s

* Avo

id in

alle

rgie

s to

dai

sy fa

mily

: rag

wee

d, c

hrys

an-

them

ums,

mar

igol

ds, a

nd d

aisi

es: r

isk

of a

naph

y-la

xis

or o

ther

alle

rgic

rea

ctio

n

* avo

id w

ith

alle

rgie

s to

oni

ons,

gar

lic, a

nd a

rtem

esia

* avo

id t

akin

g w

ith

alco

hol

AD

Rs:

Seda

tion

↓B

P, B

S, ↑

hear

t ra

te

Vom

itin

g

Ast

hma

Alt

er m

ense

s

↑ b

leed

ing

risk

DR

UG

INT

ERA

CT

ION

S:

CYP

450

inte

ract

ions

CN

S de

pres

sant

s: ↑

seda

tion

War

fari

n:↑

INR

Ant

idia

beti

c ag

ents

: ↓ B

S

Ant

icoa

gula

nts:

↑bl

eedi

ng r

isk

Ant

iarr

hyth

mic

s: ↑

hea

rt r

ate

Flow

ers

used

to

mak

e ta

b-le

ts, e

xtra

ct, t

ea, c

ream

s,

mou

th r

inse

, bat

h ad

diti

ves

Tea:

up

to 8

g dr

ied

flow

ers

Cap

sule

s: u

p to

16

00 m

g/da

y

Cre

am: 2

%-1

0%

cham

omile

ext

ract

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Dan

delio

n◆

◆us

ed in

Nat

ive

Am

eric

an a

nd

Ara

bic

med

icin

e

Use

s: li

ver

or k

idne

y to

nics

Diu

reti

cs

GI d

istu

rban

ces

Hig

h V

itam

in A

con

tent

and

hig

h po

tass

ium

con

tent

in d

ried

her

b

Stud

ies:

no

scie

ntifi

c ev

iden

ce fo

r m

edic

al c

ondi

tion

s

May

hav

e di

uret

ic a

nd im

mun

e-m

odul

atin

g ef

fect

s

May

hav

e an

tiox

idan

t ef

fect

s

* som

e al

lerg

ies/

anap

hyla

xis

to d

ande

lions

* som

e re

port

s of

GI u

pset

wit

h us

e

* do

not

use

wit

h ga

llbla

dder

dis

ease

as ↑

bile

sec

reti

on

AD

Rs:

Ast

hma

exac

erba

tion

↓pl

atel

ets

↑po

tass

ium

V t

ach,

V fi

b

↓bs

Alt

ers

estr

ogen

, pro

gest

eron

e, F

SH

DR

UG

INTE

RA

CTI

ON

S:

Ant

idia

beti

c ag

ents

, est

roge

ns (↑

effe

ct),

diu

reti

cs

(↑ef

fect

), n

iaci

n (↑

effe

ct);

anti

arrh

ythm

ics ↑

arr

hyth

mia

Leav

es a

nd r

oots

or

who

le

plan

t, u

sed

fres

h or

dri

ed

in t

eas,

cap

sule

s, o

r ex

trac

ts.

Dan

delio

n le

aves

use

d in

sa

lads

or

as c

ooke

d gr

een

Flow

ers

used

for

win

e

Don

g Q

uai

◆◆

from

Ang

elic

a si

nens

is p

lant

D

ysm

enor

rhea

l

Men

opau

sal s

ympt

oms

Men

stru

al H

/A

Poss

ible

ant

i-inf

lam

mat

ory,

an

tiox

idan

t ef

fect

s

Poss

ible

ant

ispa

smod

ic, G

I st

imul

ant

effe

cts

Poss

ible

ant

ipla

tele

t ef

fect

(c

oum

arin

der

ivat

ive)

Ant

iarr

hyth

mic

eff

ect

* avo

id in

pre

gnan

cy/l

acta

tion

; can

cau

se u

teri

ne

cont

ract

ions

and

con

geni

tal m

alfo

rmat

ions

* avo

id in

ble

edin

g di

sord

ers,

do

not

use

wit

h an

tico

agul

ants

* pos

sibl

e ca

rcin

ogen

ic p

oten

tial

AD

Rs:

Seda

tion

↓bp

GI s

ympt

oms

Ble

edin

g

DR

UG

INT

ERA

CT

ION

S:

Ant

icoa

gula

nts

Hor

mon

al m

edic

atio

ns

anti

hype

rten

sive

s

Roo

t us

ed fo

r ca

psul

e

or t

able

ts

Med

icin

al u

se s

afet

y

is u

ncle

ar

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Echi

nace

a “p

urpl

e co

neflo

wer

”Im

mun

e-st

imul

ant

Use

d fo

r U

RIs

and

oth

er in

fect

ions

, in

clud

ing

wou

nds

Stud

ies:

con

flict

ing

stud

ies

on u

sefu

l-ne

ss fo

r tr

eati

ng U

RIs

, som

e po

siti

ve

NC

CA

M s

tudy

ing

usef

ulne

ss fo

r im

mun

ity

Ger

man

E c

omm

issi

on a

ppro

ved

for

trea

tmen

t of

col

ds, c

hron

ic r

espi

ra-

tory

and

GU

tra

ct in

fect

ions

Use

d fo

r ge

nita

l her

pes

May

hav

e an

ti-in

flam

mat

ory,

ant

ifun-

gal,

and

free

rad

ical

sca

veng

er e

ffec

ts

May

be

imm

une

supp

ress

ant

or

imm

une

stim

ulan

t

* Pot

enti

al a

naph

ylac

tic

or a

llerg

ic r

eact

ions

, ast

hma,

es

peci

ally

wit

h al

lerg

y to

dai

sy fa

mily

: mar

igol

ds,

chry

sant

hem

ums,

dai

sies

, rag

wee

d.

* Alle

rgie

s m

ore

com

mon

in t

hose

who

are

ato

pic,

w

ith

ecze

ma

or a

sthm

a

* Avo

id in

peo

ple

need

ing

imm

unos

uppr

essi

on

* Avo

id in

pre

gnan

cy/l

acta

tion

* Dis

cont

inue

bef

ore

surg

ery

or m

ay a

ffec

t w

ound

he

alin

g an

d in

fect

ion

rate

* Avo

id in

aut

oim

mun

e di

seas

e, c

olla

gen

vasc

ular

di

seas

e, H

IV, l

iver

dis

ease

, MS,

TB

AD

Rs:

Ras

hes

GI s

ide

effe

cts

Diz

zine

ss, n

ervo

usne

ss, H

/A

Atr

ial f

ibri

llati

on, p

alpi

tati

ons

HTN

Ast

hma

exac

erba

tion

May

agg

rava

te a

utoi

mm

une

dise

ase

or in

crea

se

imm

une

resp

onse

DR

UG

INT

ERA

CT

ION

S:

Am

oxic

illin

: rha

bdom

yoly

sis,

dea

th

Ant

icoa

gula

nts:↑

blee

ding

Cor

tico

ster

oids

:↓im

mun

osup

pres

sive

eff

ect

Stat

ins,

ace

tam

inop

hen:↑

risk

hep

atot

oxic

ity

Plan

t an

d ro

ots

used

to

mak

e ju

ice

(exp

ress

ed),

te

as, e

xtra

cts,

oth

er fo

rms.

Dos

e: U

RI 5

00-1

000m

g ti

d

Dos

e: p

edia

tric

dos

ing

usua

lly w

eigh

t-ba

sed,

see

ot

her

sour

ces

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Ephe

dra

“ma

huan

g”◆

◆ev

ergr

een

shru

b th

at h

as b

een

used

50

00 y

ears

in In

dia

and

Chi

na◆

◆po

wer

ful s

tim

ulan

t of

ner

vous

0s

yste

m a

nd h

eart

use

d to

tre

at

resp

irat

ory

cond

itio

ns, f

lu,

asth

ma,

feve

r

Use

s:

Wei

ght

loss

Ener

gy s

uppl

emen

t

Ath

leti

c pe

rfor

man

ce

Am

phet

amin

e-lik

e; p

rim

ary

com

po-

nent

is e

phed

rine

Stud

ies:

hig

her

rate

of c

alls

to

pois

on

cont

rol c

ente

rs a

bout

sev

ere

side

ef

fect

s

Stud

ies:

↑ri

sk s

trok

e, H

TN, c

ardi

ac

prob

lem

s, G

I sid

e ef

fect

s

Ris

ks o

f ben

efit

for

shor

t te

rm w

eigh

t lo

ss is

out

wei

ghed

by

risk

s

* US

bann

ed s

ale

of d

ieta

ry s

uppl

emen

ts w

ith

ephe

dra

in 2

004

* rep

orts

of

stro

ke, M

I, su

dden

dea

th

* can

wor

sen

diab

etes

, CV

D, r

enal

dis

ease

* can

cau

se s

eizu

res

* Do

not

use

in p

regn

ancy

/lac

tati

on

AD

Rs:

Anx

iety

, psy

chos

is, t

rem

ors

Dry

mou

th, G

I irr

itat

ion,

nau

sea

HTN

, arr

hyth

mia

, hea

rt d

amag

e

Uri

nary

obs

truc

tion

Slee

p pr

oble

ms

DR

UG

INT

ERA

CT

ION

S:

Ane

sthe

tics

-alt

er e

ffec

t, ↑

bp

ETO

H-p

sych

osis

wit

h ca

ffei

ne

Caf

fein

e-↑

toxi

city

Ant

idia

beti

c ag

ents↓

effe

ct

anti

conv

ulsa

nts↓

effe

ct

ergo

t al

kalo

ids↑

hype

rten

sive

cri

sis

phen

othi

azin

es↑

arrh

ythm

ia, d

eath

Dri

ed s

tem

s an

d le

aves

m

ake

tabl

ets,

tin

ctur

es,

caps

ules

, tea

s

Ephe

dra

still

allo

wed

in

Chi

nese

her

bal r

emed

ies

and

teas

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Even

ing

Pri

mro

se O

il (E

PO

) Ye

llow

flow

er:

◆◆

cont

ains

gam

ma-

linol

enic

aci

d (G

LA),

ess

enti

al fa

tty

acid

, re

quir

ed b

y th

e bo

dy a

nd

obta

ined

from

the

die

t.

Use

s: e

czem

a, in

flam

mat

ion

Mas

talg

ia, P

MS

Men

opau

se s

ympt

oms

Can

cer

Dia

bete

s m

ellit

us

Stud

ies:

sho

w s

ome

bene

fit fo

r rh

eum

atoi

d ar

thri

tis,

ecz

ema,

PM

S, m

asta

lgia

May

hav

e an

ti-in

flam

mat

ory,

va

sodi

lato

ry, a

nd a

nti-p

late

let

ef

fect

s

* Not

for

preg

nanc

y/la

ctat

ion:

↑ri

sk c

ompl

icat

ions

, ru

ptur

e of

mem

bran

es

AD

Rs:

GI u

pset

H/A

Ras

h

Dep

ress

ion

Seiz

ures

in p

ts w

itho

ut s

eizu

re r

isk

DR

UG

INT

ERA

CT

ION

S:

Ane

sthe

sia:

↓se

izur

e th

resh

old

Ant

icoa

gula

nts:↑

blee

ding

ris

k

Ant

ihyp

erte

nsiv

es:↓

bp

TCA

s: ↓

seiz

ure

thre

shol

d

Ant

isei

zure

age

nts:↑

risk

sei

zure

s

Oil

extr

acte

d fr

om s

eeds

an

d pu

t in

cap

sule

s

Prod

ucts

sta

ndar

dize

d

for

8% G

LA a

nd 7

2%

linol

eic

acid

Fenu

gree

k◆

◆us

ed b

ack

to E

gypt

ian

tim

es◆

◆U

sed

to in

duce

chi

ldbi

rth

◆◆

Use

d to

hel

p di

gest

ion

and

men

opau

se s

ympt

oms

Use

d in

coo

king

Use

d fo

r di

abet

es m

ellit

us

Hyp

erlip

idem

ia

Loss

of a

ppet

ite

Stim

ulat

es m

ilk p

rodu

ctio

n

* Avo

id in

pre

gnan

cy

AD

Rs:

Blo

atin

g, fl

atul

ence

, dia

rrhe

a

Hyp

ogly

cem

ia

Hyp

okal

emia

Mis

carr

iage

DR

UG

INT

ERA

CT

ION

S:

Alc

ohol

-↓he

pato

toxi

city

Ana

lges

ics-

addi

tive

eff

ects

Ant

icoa

gula

nts-↑

blee

ding

ris

k

Ant

idia

beti

c ag

ents

-↑hy

pogl

ycem

ia

Seed

s ar

e gr

ound

and

ta

ken

oral

ly o

r pu

t in

pa

ste

for

skin

Dos

e: 2

5 g

seed

pow

der

daily

in d

ivid

ed d

oses

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Feve

rfew

“ba

chel

or’s

but

tons

” “w

ild c

ham

omile

”◆

◆U

sed

as a

ntip

yret

ic b

y

anci

ent

Gre

eks

Mig

rain

e he

adac

hes

Psor

iasi

s

Ast

hma

Tinn

itus

N/V

Stud

ies:

Sugg

est

may

hel

p pr

even

t (n

ot

acut

ely

trea

t) m

igra

ine

head

ache

s an

d rh

eum

atoi

d ar

thri

tis

pain

* Alle

rgic

ris

k w

ith

ragw

eed,

chr

ysan

them

um a

llerg

ies

* Not

for

use

in p

regn

ancy

/lac

tati

on, c

an c

ause

m

isca

rria

ge, p

rem

atur

e bi

rth

* Avo

id in

chi

ldre

n* A

void

pri

or t

o su

rger

y or

den

tal p

roce

dure

sA

DR

s:C

anke

r so

res,

sor

e to

ngue

Loss

of a

ppet

ite

Nau

sea/

GI s

ympt

oms

Ris

k w

orse

ned

depr

essi

onD

izzi

ness

, fat

igue

,anx

iety

Palp

itat

ions

, ↑he

art

rate

DR

UG

INT

ERA

CT

ION

S:A

ntic

oagu

lant

s: ↑

blee

ding

ris

kV

asod

ilato

rs:↑

vas

odili

tati

on

Dri

ed le

aves

pri

mar

ily u

sed

Stem

s an

d ro

ots

som

e-ti

mes

use

d

Extr

acts

, tab

lets

, cap

sule

s

Stan

dard

ized

dos

e: u

p to

25

0mg

daily

Take

wit

h fo

od

Gar

lic◆

◆ed

ible

her

b fr

om L

ily fa

mily

Use

s: h

yper

lipid

emia

CA

D, H

TN

Col

on a

nd g

astr

ic c

ance

r

UR

I pre

vent

ion

PVD

Stud

ies:

on

low

erin

g ch

oles

tero

l, ha

d va

ryin

g be

nefit

Stud

ies:

pos

itiv

e fo

r

decr

easi

ng B

P an

d

decr

easi

ng a

ther

oscl

eros

is

Stud

y: s

how

s af

fect

s di

lati

on a

nd

cons

tric

tion

of b

lood

ves

sels

* saf

e fo

r m

ost

adul

ts* d

oes

have

blo

od-t

hinn

ing

effe

ct; s

top

pre-

oper

ativ

ely

* mild

ris

k al

lerg

y, m

ostl

y ra

w fo

rm; c

ross

-alle

rgie

s w

ith

onio

ns, l

eeks

, chi

ves

AD

Rs:

Raw

: hal

itos

is,G

I ups

et, b

ody

odor

Con

tact

der

mat

itis

, blis

ters

Ble

edin

gA

sthm

a, r

hini

tis

DR

UG

INT

ERA

CT

ION

S:A

ntic

oagu

lant

s ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↓

bpA

ntid

iabe

tic

agen

ts ↓

or ↑

bsA

nest

heti

cs p

rolo

ng e

ffec

tA

ceta

min

ophe

n-al

ters

eff

ect

Prot

ease

inhi

bito

rs ↓

effe

ctO

CP

wit

h es

trog

en ↓

effe

ct

Raw

, coo

ked,

dri

ed,

pow

dere

d

Dos

e: 6

00-9

00 m

g ga

rlic

po

wde

r (i

n st

anda

rdiz

ed

1.3%

alli

cin

acti

ve in

gred

i-en

t) d

aily

in d

ivid

ed d

oses

Or

3-5m

g al

licin

dai

ly

(equ

ival

ent

to 2

-5 g

fr

esh

garl

ic)

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Gin

ger

◆◆

trop

ical

pla

nt o

ften

use

d in

A

sian

med

icin

e

Use

s: p

ost-

surg

ical

and

m

otio

n na

usea

GI u

pset

Che

mot

hera

py n

ause

a

Preg

nanc

y na

usea

(h

yper

emes

is g

ravi

daru

m)

Art

hrit

is p

ain,

mus

cle

pain

Stud

ies:

sho

rt-t

erm

eff

ecti

vene

ss in

pr

egna

ncy

naus

ea, v

aria

ble

effe

ctiv

e-ne

ss in

oth

er fo

rms

naus

ea

Stud

ies:

on

infla

mm

atio

n on

goin

g

May

inhi

bit

sero

toni

n 5-

HT 3

rece

ptor

s in

GI t

ract

May

inhi

bit

plat

elet

agg

rega

tion

May

hav

e lip

id-lo

wer

ing,

an

tihy

pert

ensi

ve e

ffec

t

* Avo

id in

lact

atio

n/sa

fety

not

est

ablis

hed

* Avo

id p

eri-o

pera

tive

ly d

ue t

o bl

eedi

ng r

isk

* Avo

id in

CA

D, a

rrhy

thm

ia h

isto

ry

AD

Rs:

Mos

tly

wit

h po

wde

red

ging

er: b

loat

ing,

gas

, he

artb

urn,

nau

sea

Dep

ress

ion

Arr

hyth

mia

s

↑ b

leed

ing

risk

DR

UG

INT

ERA

CT

ION

S:

Cal

cium

cha

nnel

blo

cker

s↓bp

Ant

idia

beti

c ag

ents

↓bs

Car

diac

age

nts-

may

alt

er e

ffec

t

anti

coag

ulan

ts↑

blee

ding

ris

k

anti

arrh

ythm

ics ↑

risk

Fres

h, p

owde

r, t

able

ts

Dos

e: u

p to

4 g

/day

in

divi

ded

dose

s

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Gin

gko

“Jap

anes

e si

lver

apr

icot

” “f

ossi

l tre

e”◆

◆se

eds

of G

ingk

o tr

ee u

sed

for

thou

sand

s of

yea

rs in

Tra

diti

onal

C

hine

se M

edic

ine

Use

s: m

emor

y en

hanc

emen

t

Prev

enti

on A

lzhe

imer

’s d

isea

se

and

dem

enti

as

Isch

emic

str

oke

Dec

reas

e in

term

itte

nt c

laud

icat

ion

MS

Tinn

itus

Sexu

al d

ysfu

ncti

on

Stud

ies:

mos

t st

udie

s sh

ow n

o im

prov

emen

t fo

r m

emor

y or

pre

ven-

tion

of d

emen

tia

or d

ecre

asin

g B

P

Stud

ies:

min

imal

ben

efit

pos

sibl

e fo

r in

term

itte

nt c

laud

icat

ion

and

tinn

itus

(v

aria

ble)

; bei

ng s

tudi

ed fo

r el

ectr

ic

shoc

k m

emor

y lo

ss

* Pos

sibl

e se

vere

alle

rgic

rea

ctio

ns

* Avo

id p

re-o

pera

tive

ly o

r be

fore

den

tal p

roce

dure

s,

incr

ease

d bl

eedi

ng r

isk

* No

raw

gin

gko

seed

s, c

onta

in t

oxin

tha

t ca

n ca

use

seiz

ures

and

dea

th

AD

Rs:

H/A

, diz

zine

ss

GI s

ympt

oms

↑bl

eedi

ng r

isk

DR

UG

INT

ERA

CT

ION

S

Ant

idia

beti

c ag

ents

: ↑bs

Ant

icoa

gula

nts ↑

blee

ding

Ant

icon

vuls

ants

↓ef

fect

Ant

ihyp

erte

nsiv

es ↓

bp

Ant

ipsy

chot

ics

can

caus

e pr

iapi

sm

Estr

ogen

s m

ay h

ave

estr

ogen

ic e

ffec

t

Nife

dipi

ne ↑

conc

entr

atio

ns

Prilo

sec ↓

leve

ls

SSR

Is↑

ser

oton

in s

yndr

ome

Traz

adon

e ri

sk c

oma

Gin

gko

leaf

abs

trac

ts u

sed

in t

able

ts, c

apsu

les,

tea

s an

d sk

in p

repa

rati

ons

Als

o in

nut

riti

on b

ars,

su

blin

gual

spr

ay

Stan

dard

ized

ext

ract

s

Dos

e: 8

0-24

0mg/

day

divi

ded

in b

id-t

id

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Gol

dens

eal “

yello

w r

oot”

◆◆

Nat

ive

Am

eric

an r

emed

y◆

◆N

ow g

row

n co

mm

erci

ally

due

to

shor

t su

pplie

s

UR

I’s

Dig

esti

ve d

isor

ders

, dia

rrhe

a

Som

e ca

ncer

s

Vag

init

is

Wou

nds

Can

ker

sore

s

Chl

oroq

uine

res

ista

nt m

alar

ia

Hyp

erlip

idem

ia

Stim

ulat

es im

mun

e sy

stem

Stud

ies:

sho

w s

ome

anti

bact

eria

l ef

fect

and

lipi

d-lo

wer

ing

effe

ct;

Stud

ies:

pos

sibl

e be

nefit

for

diar

rhea

an

d ey

e in

fect

ions

* Avo

id in

pre

gnan

cy/l

acta

tion

; con

tain

s be

rber

ine

whi

ch c

an c

ause

jaun

dice

* Not

for

infa

nts

or y

oung

chi

ldre

n

AD

Rs:

Arr

hyth

mia

s, B

rady

card

ia

H/A

,↓B

P

↓bl

ood

suga

r

GI i

rrit

atio

n, n

ause

a

Dry

muc

ous

mem

bran

es

Seiz

ures

DR

UG

INT

ERA

CT

ION

S:

Ant

ipla

tele

t ag

ents

Ant

ilipe

mic

age

nts ↑

effe

ct

Ant

imal

aria

ls-a

ddit

ive

effe

cts

Bet

a bl

ocke

rs-c

hang

es e

ffec

t

Phen

ylep

hrin

e-↑

effe

cts

War

fari

n-↓

effe

cts

Stem

s an

d ro

ots

drie

d fo

r ex

trac

ts a

nd t

eas

Mou

th r

inse

s

Som

etim

es c

ombi

ned

wit

h Ec

hina

cea

for

UR

Is

Tabl

ets/

caps

ules

0.

5-1g

po

tid

Extr

act:

0.3

ml-1

ml

Als

o IV

and

oph

thal

mic

fo

rms

Hoo

dia

“kal

ahar

i cac

tus”

◆◆

Kal

ahar

i bus

hmen

ate

thi

s to

su

ppre

ss h

unge

r an

d th

irst

w

hile

hun

ting

App

etit

e su

ppre

ssan

t (w

eigh

t lo

ss)

whi

le e

leva

ting

ene

rgy

Stud

ies:

non

e pu

blis

hed

Dru

g ri

sks,

inte

ract

ions

, adv

erse

eff

ects

hav

e no

t be

en s

tudi

ed

Avo

id in

pre

gnan

cy

Oft

en c

ombi

ned

wit

h gr

een

tea

or c

hrom

ium

Dri

ed e

xtra

cts

from

ste

ms

and

root

s m

ake

caps

ules

, ex

trac

ts, p

owde

rs, t

eas,

ch

ewab

le t

able

ts

Dos

e: D

ried

ext

ract

up

to

800m

g/da

y

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Hor

se C

hest

nut

“buc

keye

”◆

◆O

nly

seed

ext

ract

is s

afe

◆◆

Do

not

use

any

othe

r pa

rts

of

plan

t, w

hich

may

be

toxi

c

Use

d fo

r ch

roni

c ve

nous

insu

ffic

ienc

y

Use

d fo

r an

kle

edem

a,

nigh

t le

g cr

amps

Stud

ies

show

it is

as

effe

ctiv

e fo

r ve

nous

insu

ffic

ienc

y as

sup

port

ive

com

pres

sion

sto

ckin

gs

* Con

trai

ndic

ated

in h

epat

ic a

nd r

enal

impa

irm

ent;

in

flam

mat

ory

bow

el d

isea

se* C

ontr

aind

icat

ed in

late

x al

lerg

yA

void

in p

regn

ancy

/lac

tati

onA

DR

s: c

alf s

pasm

GI u

pset

Ble

edin

gR

enal

/liv

er d

amag

eD

RU

G IN

TER

AC

TIO

NS:

anti

coag

ulan

ts↑

blee

ding

anti

diab

etic

age

nts ↑

hypo

glyc

emia

anti

hype

rten

sive

↑ h

ypot

ensi

on

Dos

e: 3

00 m

g ex

trac

t bi

d

Topi

cal g

el 3

-4 x

/day

Use

for

shor

t te

rm o

nly

Stan

dard

ized

for

15

-20%

esc

in

Kav

a “k

ava

kava

”◆

◆M

embe

r of

pep

per

fam

ily◆

◆C

erem

onia

l bev

erag

e in

So

uth

Paci

fic

Use

s: a

nxie

ty

Inso

mni

a

Men

opau

sal s

ympt

oms

NC

CA

M s

tudi

es h

alte

d du

e to

ris

k

of s

ever

e liv

er d

amag

e

Earl

ier

stud

ies

show

ed s

ome

bene

fit

wit

h an

xiet

y, b

ut d

ange

rs

outw

eigh

ris

ks

May

impa

ct c

ereb

ella

r an

d

GA

BA

func

tion

s

* Ris

k of

sev

ere

liver

dam

age,

incl

udin

g liv

er f

ailu

re

and

hepa

titi

s* R

isk

dyst

onia

(ab

norm

al m

uscl

e m

ovem

ents

)A

DR

s:D

row

sine

ssA

taxi

aD

izzi

ness

, dys

kine

sia

H/A

Tach

ycar

dia

Con

tact

der

mat

itis

, kav

a de

rmop

athy

(ra

sh fr

om

long

-ter

m w

ith

yello

w d

isco

lora

tion

)G

I ups

et, ↑

tran

sam

inas

esPa

rkin

soni

smD

RU

G IN

TER

AC

TIO

NS:

Ace

tam

inop

hen ↑

liver

tox

icit

yPs

ycho

trop

ics-

alte

red

men

tal s

tatu

sET

OH

↑to

xici

tyA

nxio

lyti

cs ↑

effe

ctSe

dati

ves ↑

effe

ctO

pioi

ds ↑

seda

tion

, CN

S de

pres

sion

Roo

t an

d rh

izom

e m

ake

beve

rage

s, c

apsu

les,

ta

blet

s, e

xtra

cts,

to

pica

l sol

utio

ns

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Lave

nder

“En

glis

h la

vend

er”

Use

s: a

nxie

ty, d

epre

ssio

n

Inso

mni

a

GI u

pset

Alo

peci

a

Topi

cal a

ntis

epti

c

arom

athe

rapy

Stud

ies:

do

not

conf

irm

any

ben

efit

s fo

r ce

rtai

n ex

cept

for

alop

ecia

use

d to

pica

lly

* Avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

H/A

, pho

tose

nsit

ivit

y

GI s

ympt

oms

Skin

pig

men

t ch

ange

s

DR

UG

INT

ERA

CT

ION

S

Anx

ioly

tics

↑si

de e

ffec

t

Seda

tive

s↑ s

ide

effe

ct

Ant

idep

ress

ants

↑ s

ide

effe

ct

Dri

ed la

vend

er t

eas

or

extr

acts

can

be

take

n or

ally

Esse

ntia

l oils

can

be

mad

e fr

om fl

ower

s an

d us

ed

topi

cally

and

in a

rom

a-th

erap

y; p

oiso

nous

if

take

n in

tern

ally

Lico

rice

Roo

t◆

◆G

lycy

rrhi

zin

is m

ost

dang

erou

s co

mpo

und

◆◆

Dec

lycy

rrhi

zina

ted

form

“D

GL”

is

saf

er

Use

s: s

tom

ach

ulce

r, h

epat

itis

Sore

thr

oat,

bro

nchi

tis

Stud

ies:

non

e sh

ow s

igni

fican

t ef

fec-

tive

ness

exc

ept

IV fo

rm fo

r H

epat

itis

C

, not

ava

ilabl

e in

US

* gly

cyrr

hizi

n ca

n→ lo

w p

otas

sium

, hig

h bl

ood

pres

sure

, sal

t an

d w

ater

ret

enti

on, a

ll ri

sks

for

CV

D: A

VO

ID

* hig

h le

vels

of

licor

ice

affe

ct c

orti

sone

* Not

for

pre

gnan

cy—

can

caus

e pr

eter

m la

bor

* Not

for

hyp

erte

nsio

n or

CA

D

AD

Rs:

DR

UG

INT

ERA

CT

ION

S:

Avo

id w

ith

med

icat

ions

tha

t af

fect

pot

assi

um,

diur

etic

s, p

redn

ison

e

Ant

iarr

hyth

mic

s-↑

risk

Ant

icoa

gula

nts ↑

blee

ding

Imm

unos

uppr

essa

nts ↓

effe

ct

Ant

idia

beti

cs a

lter

eff

ect

Ant

ihyp

erte

nsiv

es ↓

effe

ct

Use

DG

L fo

rm in

stea

d—m

uch

safe

r

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Milk

Thi

stle

“ho

ly t

hist

le”,

“s

ilym

arin

”◆

◆U

sed

for

thou

sand

s of

yea

rs fo

r liv

er a

ssis

tanc

e

Use

s: c

hron

ic h

epat

itis

Cir

rhos

is

Live

r da

mag

e fr

om d

rugs

and

tox

ins;

al

coho

lic li

ver

dise

ase

Hyp

erlip

idem

ia

Dec

reas

e in

sulin

res

ista

nce

if ha

ve

DM

and

cir

rhos

is

Ant

i-bre

ast,

cer

vica

l, pr

osta

te c

ance

r

Stud

ies:

pri

or s

tudi

es s

how

ed b

enef

it

prot

ecti

ng a

nd p

rom

otin

g gr

owth

of

live

r ce

lls; l

ater

stu

dies

con

flict

ing

resu

lts

Stud

y: b

enef

it in

Hep

atit

is C

sho

wed

fe

wer

, mild

er li

ver

dise

ase

sym

ptom

s bu

t no

aff

ect

on a

mou

nt o

f vir

al lo

ad

* Avo

id in

alle

rgie

s in

dai

sy fa

mily

: rag

wee

d,

chry

sant

hem

ums,

dai

sies

, mar

igol

d.

* Not

rec

omm

ende

d in

pre

gnan

cy/l

acta

tion

AD

Rs:

↓bs

GI s

ide

effe

cts

H/A

, ins

omni

a

Exac

erba

tes

hem

ocho

mat

osis

arth

ralg

ia

DR

UG

INT

ERA

CT

ION

S

Alc

ohol↓

alco

hol-i

nduc

ed h

epat

oxic

ity

Stat

ins-

inhi

bits

eff

ects

Ant

ineo

plas

tic

drug

s ↑

effe

cts

Ant

idia

beti

c ag

ents

↓bs

Sily

mar

in, a

ctiv

e in

gred

i-en

t, fr

om s

eeds

use

d to

m

ake

tinc

ture

s, c

apsu

les,

ex

trac

ts

Gen

eral

ly c

onsi

dere

d sa

fe

Dos

e: 2

30-8

00m

g/da

y di

vide

d in

2-3

dos

es

Non

i “In

dian

mul

berr

y”◆

◆H

isto

ry o

f top

ical

use

for

join

t pa

in

and

derm

atol

ogic

al is

sues

Use

d in

juic

e as

hea

lth

toni

c

Use

d fo

r ch

roni

c co

ndit

ions

e.g

. di

abet

es, c

ardi

ovas

cula

r di

seas

e

Use

d fo

r ca

ncer

, hea

ring

loss

Stud

ies:

ear

ly s

tudi

es s

how

an

ti-c

ance

r ef

fect

, ant

ioxi

dant

, an

d im

mun

e-st

imul

atin

g ef

fect

s

NC

CA

M s

tudy

-on

pros

tate

can

cer

NC

I stu

dy-o

n br

east

can

cer

prev

enti

on

* Ris

k of

live

r to

xici

ty

* Hig

h in

pot

assi

um-a

void

in r

enal

dis

ease

* Not

for

use

in p

regn

ancy

(ha

s be

en

trad

itio

nal a

bort

iface

nt)

AD

Rs:

↓bp

DR

UG

INT

ERA

CT

ION

S:

Ant

icoa

gula

nts-

cont

ains

Vit

amin

K in

som

e,

not

all p

repa

rati

ons

AC

E in

hibi

tors

↑po

tass

ium

Num

erou

s ot

hers

tha

t af

fect

pot

assi

um

Frui

t us

ed in

frui

t ju

ices

, m

ostl

y w

ith

grap

e

Frui

t an

d le

aves

can

mak

e ta

blet

s, c

apsu

les,

tea

s

Dos

e: u

p to

2 o

z tw

ice

daily

x 3

mon

ths

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Pep

perm

int

Oil

◆◆

Cro

ss b

etw

een

spea

rmin

t

and

wat

erm

int

Seas

onin

g an

d m

edic

inal

Nau

sea,

GI u

pset

, ind

iges

tion

IBS

UR

I, H

/A

asth

ma

Mus

cula

r, a

ntis

pasm

odic

or

ne

rve

pain

Hal

itos

is

Nas

al c

onge

stio

n

Stud

ies:

pep

perm

int

may

hel

p IB

S

Stud

ies:

pep

perm

int

wit

h ca

raw

ay

mig

ht h

elp

indi

gest

ion

* Oil

is s

afe

in s

mal

l dos

es

* Not

for

preg

nanc

y/la

ctat

ion

AD

Rs:

Hea

rtbu

rn

Abd

omin

al p

ain

Acu

te r

enal

failu

re

Con

tact

der

mat

itis

Bur

ning

mou

th s

yndr

ome

DR

UG

INT

ERA

CT

ION

S:

Ant

acid

s/H

2 bl

ocke

rs/P

PIs—

may

pre

mat

urel

y di

ssol

ve e

nter

ic c

oati

ng

CYP

450

inte

ract

ions

pos

sibl

e

Esse

ntia

l oil

of p

eppe

rmin

t

In s

mal

l dos

es in

cap

sule

s or

liqu

ids

In t

eas

Mix

ed w

ith

othe

r in

gred

i-en

ts in

top

ical

pre

para

tion

s

Dos

ing:

PO d

iges

tive

: 0.2

-0.4

ml t

id

(ave

rage

qd

is 6

-12

gtts

)

Cap

sule

s: 1

-2 c

aps

po t

id

½ h

our

ac.

Teas

wit

h dr

ied

leav

es

Topi

cal p

repa

rati

ons

Red

Clo

ver

“mea

dow

clo

ver”

◆◆

Legu

me

fam

ily◆

◆C

onta

ins

phyt

oest

roge

ns w

hich

ac

t lik

e es

trog

en◆

◆Pa

st u

se p

ertu

ssis

, ast

hma,

br

onch

itis

, can

cer

Use

d fo

r m

enop

ausa

l sym

ptom

s

Mas

talg

ia

Ost

eopo

rosi

s

Ben

ign

pros

tati

c hy

pert

roph

y

Hyp

erlip

idem

ia

Stud

ies:

not

eno

ugh

evid

ence

for

effe

ctiv

enes

s or

saf

ety

in m

enop

ause

Stud

ies:

NC

CA

M s

tudy

ing

how

it

affe

cts

pros

tate

cel

ls

Stud

y: if

cau

ses

endo

met

rial

ca

ncer

ris

k

* Pre

gnan

cy/l

acta

tion

: uns

afe

in m

edic

inal

am

ount

s

* may

incr

ease

ris

k of

bre

ast

canc

er o

r ot

her

horm

one-

sens

itiv

e ca

ncer

s

AD

Rs:

Mas

talg

ia

Men

stru

al c

hang

es

Vag

inal

spo

ttin

g

H/A

, ras

h

DR

UG

INT

ERA

CT

ION

S:

anti

coag

ulan

ts↑

blee

ding

Tam

oxife

n-al

tere

d ef

fect

Estr

ogen

s-al

tere

d ef

fect

Flow

ers

used

in t

able

ts,

caps

ules

, tea

s, e

xtra

cts

Dos

e: 4

0-80

mg

red

clov

er

isof

lavo

nes/

day

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Rho

diol

a◆

◆co

nsid

ered

ada

ptog

en

Use

d fo

r en

ergy

and

exe

rcis

e en

hanc

emen

t

Fati

gue

gene

raliz

ed a

nxie

ty d

isor

der

blad

der

canc

er

hypo

xia

Avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

Inso

mni

a↑

BP

Der

mat

itis

Irri

tabi

lity

Dry

mou

thLe

ukoc

ytos

isD

RU

G IN

TER

AC

TIO

NS:

Ant

idep

ress

ants

—ad

diti

ve e

ffec

tsA

nxio

lyti

cs—

addi

tive

eff

ects

CN

S de

pres

sant

s—ad

diti

ve e

ffec

tsO

pioi

ds—

addi

tive

eff

ects

Ant

ihyp

erte

nsiv

es—

addi

tive

eff

ects

Cap

sule

s: 1

00-4

g da

ily

Sage

◆◆

Fert

ility

dru

g in

anc

ient

Egy

pt◆

◆C

lean

sed

and

stop

ped

blee

ding

in

ulce

rs/w

ound

s in

anc

ient

Gre

ece

Spic

e an

d se

ason

ing

Use

d fo

r m

outh

infla

mm

atio

n an

d so

re t

hroa

ts

Use

d fo

r in

dige

stio

n

Use

d fo

r m

enop

ausa

l sym

ptom

s

Use

d to

impr

ove

moo

d an

d bo

ost

mem

ory/

perf

orm

ance

Stud

ies:

sho

w m

enta

l and

moo

d im

prov

emen

ts; m

emor

y bo

osti

ng

in o

lder

adu

lts

Stud

ies:

sho

w t

hink

ing/

le

arni

ng im

prov

emen

t in

A

lzhe

imer

’s d

isea

se

Stud

ies:

sho

w e

ssen

tial

oil

has

anti

mic

robi

al p

rope

rtie

s

* sa

fe,b

ut s

ome

vari

etie

s co

ntai

n TH

UJO

NE

whi

ch c

an

affe

ct n

ervo

us s

yste

m, c

ausi

ng r

estl

essn

ess,

tre

mor

, se

izur

es, r

enal

tox

icit

yIn

gest

ing

sage

pow

der

can

caus

e as

thm

aIn

flam

mat

ion

wit

h sk

in c

onta

ct* A

void

in p

regn

ancy

-ris

k ab

orti

face

nt a

nd h

orm

onal

eff

ects

* Con

trai

ndic

ated

in s

eizu

re d

isor

ders

AD

Rs:

Seiz

ures

Con

tact

der

mat

itis

Hyp

erte

nsio

nSe

dati

onD

RU

G IN

TER

AC

TIO

N:

Ant

idia

beti

c dr

ugs↑

hypo

glyc

emia

Ant

icon

vuls

ants

-alt

ered

eff

ects

Thyr

oid

horm

ones

-alt

ered

eff

ects

Dri

ed le

aves

, ess

enti

al

oils

, spr

ays,

ext

ract

s

Men

opau

sal s

x:

120m

g qd

Phar

yngi

tis:

15%

spr

ay

Moo

d en

hanc

emen

t:

drie

d le

af,

300-

600m

g qd

Alz

heim

er’s

: es

sent

ial o

ils

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Saw

Pal

met

to “

dwar

f pal

m”

na

tive

to

US

“cab

bage

pal

m”

◆◆

Sem

inol

e N

ativ

e A

mer

ican

s us

ed

for

urin

ary

sym

ptom

s

Use

s: p

rost

ate

(BPH

) pr

oble

ms

pros

tati

tis

Pelv

ic p

ain

Bla

dder

pro

blem

s

Pros

tate

can

cer

Libi

do is

sues

Alo

peci

a

Incr

ease

s te

stos

tero

ne

May

be

anti

-infla

mm

ator

y an

d im

mun

e st

imul

ant

Stud

ies:

con

flict

ing

repo

rts

of

bene

fits

on B

PH s

ympt

oms

Doe

s no

t af

fect

PSA

on

stud

ies

Bei

ng s

tudi

ed fo

r af

fect

on

pr

osta

te c

ance

r

Ger

man

E C

omm

issi

on a

ppro

ves

fo

r B

PH e

arly

sta

ges

I and

II

* Mild

GI s

ympt

oms

can

be ↓

by

taki

ng w

ith

food

* Do

not

use

in p

regn

ancy

/lac

tati

on d

ue t

o

horm

onal

eff

ects

AD

Rs

Abd

omin

al p

ain

Dia

rrhe

a

N/V

Fati

gue

Sexu

al d

ysfu

ncti

on

DR

UG

INT

ERA

CT

ION

S:

Ant

ibio

tics

(C

ipro

, Azi

thro

myc

in e

spec

ially

)—ad

diti

ve

effe

cts

And

roge

ns—↓

effe

ct

Ant

icoa

gula

nts—

↑bl

eedi

ng

Ant

i-inf

lam

mat

orie

s —ad

diti

ve e

ffec

ts

Who

le o

r gr

ound

ber

ries

or

drie

d fr

uit.

In li

quid

ext

ract

s, t

able

ts,

caps

ules

, as

infu

sion

or

tea,

top

ical

for

alop

ecia

Dos

e of

cap

sule

: 320

mg

qd

Gro

und,

who

le o

r dr

ied

berr

ies—

1 or

2 q

d

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

SAM

e

S-ad

enos

ylm

ethi

onin

e

Met

hion

ine

is c

onve

rted

to

SAM

e w

ith

enzy

me

met

hion

ine

aden

osyl

tr

ansf

eras

e (M

AP)

Alc

ohol

ic li

ver

dise

ase→

liver

di

seas

e ha

s ↓

hepa

tic

SAM

e w

hich

glut

athi

one

need

ed fo

r he

pati

c de

toxi

ficat

ion

and

prev

enti

on o

f ox

idat

ive

liver

dam

age

Dep

ress

ion

Ost

eoar

thri

tis

AD

HD

Fibr

omya

lgia

Ana

lges

ic, a

nti-i

nfla

mm

ator

y

SAM

e tr

ansm

ethy

lati

on n

eces

sary

to

syn

thes

ize

and

met

abol

ize

neu-

rotr

ansm

itte

rs, p

rote

ins,

hor

mon

es,

and

mem

bran

e ph

osph

olip

ids

Prod

ucti

on o

f SA

Me

asso

ciat

ed w

ith

adeq

uate

B12

and

fola

te le

vels

SAM

e co

nver

ted

to S

-ade

nosy

l-ho

moc

yste

ine

whi

ch →

glut

athi

one

liver

ant

ioxi

dant

Can

↑do

pam

ine

and

nore

pine

phri

ne

2006

Coc

hran

e: n

o ev

iden

ce fo

r or

ag

ains

t us

e in

alc

ohol

ic li

ver

dise

ase

2008

Coc

hran

e: r

evie

w o

n O

A

use

pend

ing

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

AD

Rs:

Diz

zine

ss, H

/A, p

alpi

tati

ons

Dia

phor

esis

, ras

h, it

chy

or h

ot e

ar

Anx

iety

, ins

omni

a, fa

tigu

e

Ano

rexi

a, c

onst

ipat

ion,

N/V

/D, d

ry m

outh

AV

OID

IN B

IPO

LAR

DIS

EASE

→M

AN

IA

OR

HYP

OM

AN

IA

AV

OID

IN C

AD

, TH

RO

MB

OEM

BO

LISM

, RIS

K

HO

MO

CYS

TEI

NEM

IA

MA

Y W

OR

SEN

PA

RK

INSO

NS

SX

DR

UG

INT

ERA

CT

ION

S:

Sero

toni

nerg

ic/S

SRI→

sero

toni

n sy

ndro

me

St. J

ohn’

s W

ort→

sero

toni

n sy

ndro

me

Tric

yclic

ant

idep

ress

ants→

sero

toni

n sy

ndro

me

Tram

adol→

sero

toni

n sy

ndro

me

MA

OI→

sero

toni

n sy

ndro

me,

hyp

erte

nsiv

e cr

isis

Dex

trom

etho

rpha

n→se

roto

nin

synd

rom

e

Mep

erid

ine→

sero

toni

n sy

ndro

me

Levo

dopa

↓ef

fect

Tabl

et o

nly

in U

S

Poor

bio

avai

labi

lity

due

to

first

pas

s ef

fect

Dos

e: 8

00-1

600

mg/

day

in

2-3

divi

ded

dose

s

Mon

itor

glu

cose

, LFT

s

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

St. J

ohn’

s W

ort

“hyp

eric

um”

“g

oat’

s w

eed”

◆◆

Flow

er b

loom

s ar

ound

feas

t ti

me

of S

t. Jo

hn t

he B

apti

st in

late

June

.◆

◆us

ed fo

r ce

ntur

ies

to t

reat

men

tal

dise

ase,

ner

vous

ness

, as

seda

tive

◆◆

used

to

trea

t m

alar

ia, a

nd w

as

balm

for

wou

nds,

bur

ns, a

nd

inse

ct b

ites

.

Use

d fo

r de

pres

sion

, anx

iety

and

sl

eep

diso

rder

s

Use

d fo

r PM

S, s

easo

nal a

ffec

tive

di

sord

er, s

omat

ofor

m d

isor

ders

.

Use

d fo

r A

DH

D, b

urni

ng m

outh

sy

ndro

me,

OC

D.

Stud

ies

show

: the

re m

ay n

ot b

e

any

mor

e ef

fect

iven

ess

than

pl

aceb

o fo

r m

ajor

dep

ress

ion

of

mod

erat

e se

veri

ty

Ano

ther

stu

dy N

CC

AM

and

NIM

H

show

ed n

eith

er a

ntid

epre

ssan

t

nor

St. J

ohn’

s W

ort

trea

ted

mild

de

pres

sion

any

mor

e ef

fect

ivel

y

than

pla

cebo

Coc

hran

e re

view

200

8: b

ette

r th

an

plac

ebo

and

sim

ilar

to s

tand

ard

anti

-de

pres

sant

s w

ith

few

er s

ide

effe

cts

Hyp

erfo

rin

com

pone

nt in

hibi

ts

neur

onal

upt

ake

of d

opam

ine,

se

roto

nin,

nor

epin

ephr

ine,

GA

BA

an

d L-

glut

amat

e

* Avo

id u

se w

ith

othe

r an

tide

pres

sant

s; c

an le

ad t

o se

roto

nin

synd

rom

e. D

o no

t us

e w

ith

MA

OIs

.

* STO

P 5-

14 d

ays

pre-

oper

ativ

ely

* Do

not

use

wit

h su

icid

al id

eati

on

* Do

not

use

in p

regn

ancy

/lac

tati

on

AD

Rs:

Dro

wsi

ness

GI s

ympt

oms

Hyp

erte

nsio

n/hy

pert

ensi

ve c

risi

s

(cou

ld a

ct li

ke M

AO

I)

Man

ia

Sero

toni

n sy

ndro

me

Del

iriu

m

Con

fusi

on

psyc

hosi

s

MI

Palp

itat

ions

↑TS

H

↑A

CTH

Phot

osen

siti

vity

Dry

mou

th

dizz

ines

s

Flow

erin

g to

ps u

sed

fo

r te

as, t

able

ts,

caps

ule,

ext

ract

s,

liqui

ds, t

opic

al a

gent

s

Stan

dard

ized

ext

ract

do

se: 3

00 m

g po

tid

fo

r 4-

6 w

eeks

Sudd

en d

isco

ntin

uati

on

may

cau

se a

dver

se r

eact

ion

(con

tinue

s)

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

St. J

ohn’

s W

ort

(con

tinue

d)D

RU

G IN

TER

AC

TIO

NS:

Ane

sthe

tics

SSR

I ant

idep

ress

ants

-ser

oton

in s

yndr

ome

Ant

ican

cer

drug

s

anti

coag

ulan

ts↓

effe

ct

anti

hype

rten

sive

s ↑

bp

alco

hol-↑

seda

tion

\ or

al c

ontr

acep

tive

s-↓

cont

race

ptio

n, p

ossi

bly

brea

k-th

roug

h bl

eedi

ng

Cyc

losp

orin

and

tra

nspl

ant

drug

s↓

Dig

oxin

-↓se

rum

leve

l

Stat

ins-↓

leve

l

HIV

dru

gs-m

ay a

ffec

t

Seiz

ure

drug

s-m

ay a

ffec

t

OTC

col

d/flu

med

s—m

ay ↑

MA

O in

hibi

tion

Tea

Tre

e O

il◆

◆U

sed

by A

ustr

alia

n ab

orig

ines

for

cent

urie

s◆

◆Fr

om t

ea t

ree

Use

s: a

thle

te’s

foot

(ti

nea

pedi

s), n

ail

fung

us (

onyc

hom

ycos

is)

wou

nds,

and

infe

ctio

ns

acne

dand

ruff

lice

oral

can

didi

asis

skin

lesi

ons

anti

bact

eria

l;ant

ifung

ual;

anti

-MR

SA

Stud

y: s

how

ed b

enef

it fo

r tr

eatm

ent

of w

ound

s of

MR

SA

Stud

ies:

hav

e sh

own

som

e po

siti

ve

bene

fit fo

r ac

ne, o

nych

omyc

osis

, ti

nea

pedi

s an

d da

ndru

ff

* Do

not

take

ora

lly; p

oiso

nous

, can

lead

to

com

a,

espe

cial

ly in

chi

ldre

n

* Can

be

topi

cal i

rrit

ant

or c

ause

con

tact

der

mat

itis

* Can

be

used

top

ical

ly in

pre

gnan

cy a

ccor

ding

to

Ulb

righ

t

AD

Rs:

Con

tact

der

mat

itis

Skin

dry

ness

Oto

toxi

city

if in

still

ed in

ear

DR

UG

INT

ERA

CT

ION

S:

Topi

cal d

ryin

g ag

ents

↑dr

ynes

s

Tret

inoi

n ↑

dry

ness

Use

d to

pica

lly, 5

%-1

00%

oi

l, sa

fer

in a

dult

s

Topi

cal u

se in

you

ng b

oy

of s

tylin

g ge

l and

sha

mpo

o ca

used

bre

ast

grow

th

Is in

som

e m

outh

was

hes,

bu

t ba

sed

on t

he c

once

rns

wit

h or

al u

se, d

o no

t re

com

men

d

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Thu

nder

God

Vin

e◆

◆Fo

und

in C

hina

◆◆

Use

d in

Tra

diti

onal

Chi

nese

M

edic

ine

for

over

acti

vity

of

imm

une

syst

em o

r in

flam

mat

ion

Use

s in

clud

e M

S, S

LE, r

heum

atoi

d ar

thri

tis(

RA

)

Use

d fo

r ex

cess

ive

men

ses

HIV

/AID

S

Hyp

erlip

idem

ia

oste

oart

hrit

is

May

hav

e im

mun

e st

imul

ant

effe

cts,

to

o

Stud

ies:

sho

w a

nti-c

ance

r an

d an

ti-

infla

mm

ator

y ef

fect

s

Stud

ies:

sho

w s

uppr

essi

on o

f im

mun

e sy

stem

eff

ect

Stud

ies:

sho

wed

ben

efit

s fo

r R

A p

ain

as g

ood

as s

ulfa

sala

zine

* HIG

HLY

PO

ISO

NO

US

LEA

VES

, FLO

WER

S A

ND

SK

IN O

F R

OO

T

* Avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

GI s

ympt

oms

UR

I sym

ptom

s

Loss

of b

one

min

eral

den

sity

Dec

reas

e m

ale

fert

ility

Alo

peci

a, r

ash,

H/A

DR

UG

INT

ERA

CT

ION

S;

Ant

ihyp

erte

nsiv

es-a

lter

eff

ect

DM

AR

Ds

(ant

i-inf

lam

mat

orie

s)-↑

effe

ct

Imm

unos

uppr

essa

nts-↑

effe

cts

Extr

acts

mad

e fr

om

SKIN

NED

roo

t

No

cons

iste

nt, h

igh-

qual

ity

prod

ucts

are

mad

e in

the

U

S ye

t; C

hine

se p

rodu

cts

may

not

be

relia

ble

Tur

mer

ic “

Indi

an s

affr

on”

◆◆

Rel

ated

to

ging

er, b

itte

r ta

ste,

go

ld c

olor

◆◆

Use

d fo

r sp

ice

and

colo

r◆

◆U

sed

in T

radi

tion

al C

hine

se M

edi-

cine

and

Ayu

rved

ic M

edic

ine

for

liver

func

tion

, dig

esti

on, m

enst

rual

re

gula

tion

and

art

hrit

is p

ain

Topi

cally

, use

d fo

r w

ound

hea

ling

and

ecze

ma

Use

d or

ally

for

ulce

rs, c

ance

r,

GI p

robl

ems,

infla

mm

atio

n,

and

galls

tone

s

Stud

ies:

cur

cum

in c

hem

ical

in

turm

eric

has

ant

i-inf

lam

mat

ory,

an

ti-c

ance

r, a

nd a

ntio

xida

nt

prop

erti

es in

ear

ly s

tudi

es

NC

CA

M fu

ndin

g st

udie

s on

: AR

DS,

os

teop

oros

is a

nd li

ver

canc

er

* Hig

h do

ses

or lo

ng t

erm

use

hav

e ca

used

: G

I pro

blem

s an

d liv

er is

sues

* Do

not

use

if ha

ve g

allb

ladd

er d

isea

se; c

an w

orse

n

* Con

side

red

safe

as

spic

e in

pre

gnan

cy, b

ut c

an

stim

ulat

e ut

erus

in h

igh

dose

s, s

o un

safe

the

re.

AD

Rs:

GI p

robl

ems

Hyp

oten

sion

Alo

peci

a

Con

tact

der

mat

itis

DR

UG

INT

ERA

CT

ION

S:

anti

coag

ulan

ts↑

blee

ding

anti

diab

etic

age

nts↑

hypo

glyc

emia

anti

hype

rten

sive

s↓B

P ex

cess

ive

Rhi

zom

es (

unde

rgro

und

stem

s) (

dri

ed a

nd u

ses

as

oral

pow

der,

in c

apsu

les,

te

as, o

r liq

uid

extr

acts

.

Turm

eric

pas

te u

sed

on

ski

n.

Dos

e: r

oot

1.5-

7g in

di

vide

d da

ily d

oses

Tea:

1-1

.5 g

dri

ed r

oot

stee

ped

15 m

inut

es in

15

0ml w

ater

bid

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Val

eria

n “a

ll he

al”;

“g

arde

n he

liotr

ope”

◆◆

Use

d ba

ck t

o an

cien

t G

reec

e

and

Rom

e◆

◆D

escr

ibed

by

Hip

pocr

ates

and

G

alen

(fo

r in

som

nia)

Use

d fo

r sl

eep

diso

rder

s

Anx

iety

Dep

ress

ion

H/A

Arr

hyth

mia

May

be

aden

osin

e ag

onis

t

May

be

GA

BA

rec

epto

r m

odul

ator

May

hav

e C

NS

neur

opro

tect

ive

effe

cts

NC

CA

M r

esea

rchi

ng a

ffec

t on

sl

eep

in o

lder

adu

lts

and

Pa

rkin

son’

s pa

tien

ts

Stud

ies:

sug

gest

hel

ps in

som

nia,

not

en

ough

res

earc

h on

anx

iety

an

d de

pres

sion

Ger

man

E C

omm

issi

on a

ppro

ved

to

trea

t sl

eep

diso

rder

s fr

om n

ervo

us

cond

itio

ns a

nd r

estl

essn

ess

* Stu

dies

sho

w s

afe

for

shor

t pe

riod

s,

up t

o 4-

6 w

eeks

use

* Not

for

use

in p

regn

ancy

-pos

sibl

e

tera

toge

nic

effe

cts

AD

Rs:

Mor

ning

fati

gue

GI u

pset

Diz

zine

ss

H/A

Hal

luci

nati

ons

Ata

xia

↓H

R, ↓

BP

Dry

mou

th

Mus

cle

rela

xati

on

One

rep

ort

of w

ithd

raw

al s

x

DR

UG

INT

ERA

CT

ION

S:

Alc

ohol

↑ef

fect

anti

depr

essa

nts↑

effe

ct

benz

odia

zepi

nes ↑

effe

ct

CN

S de

pres

sant

s ↑

effe

ct

Ant

ihyp

erte

nsiv

es ↓

BP

Roo

ts a

nd r

hizo

mes

(u

nder

grou

nd s

tem

s)

mak

e ta

blet

s, t

eas,

ca

psul

es, l

iqui

d ex

trac

ts

Use

½ t

o 2

hour

s be

fore

be

d if

for

slee

p

Mon

itor

LFT

s

Dos

e:

Anx

iety

: 80-

300m

g po

qd

Inso

mni

a: 4

00-9

00 m

g 30

-60

min

. bef

ore

hs

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Yohi

mbe

“yo

him

be b

ark”

◆◆

From

bar

k of

Afr

ican

ev

ergr

een

tree

Yohi

mbe

hyd

roch

lori

de fo

rm h

as

been

stu

died

for

erec

tile

dys

func

tion

Use

d fo

r fe

mal

e lib

ido,

SSR

I-in

duce

d lib

ido

issu

es

Use

d fo

r se

xual

dys

func

tion

, ap

hrod

isia

c

Use

d fo

r at

hlet

ic p

erfo

rman

ce

Stud

ies:

no

adeq

uate

stu

dies

don

e

Con

tain

s al

pha-

2 bl

ocke

r→↑

nore

pine

phri

ne

↑ch

olin

ergi

c an

d↑sy

mpa

thet

ic t

one

* Avo

id in

pre

gnan

cy: f

etal

tox

icit

y, u

teri

ne r

elax

atio

n

* Do

not

use

in la

ctat

ion

* Do

not

use

wit

h M

AO

inhi

bito

rs, c

auti

on w

ith

othe

r an

tide

pres

sant

s an

d ph

enot

hiaz

ines

* Do

not

use

wit

h ps

ychi

atri

c or

ren

al d

isor

ders

can

exac

erba

te

* one

rep

ort

hype

rten

sive

cri

sis

* ove

rdos

e-se

vere

eff

ects

, pos

sibl

y fa

tal

AD

Rs:

Inso

mni

a

↑ o

r↓ B

P

Irri

tabi

lity,

psy

chos

is

N/V

Anx

iety

H/A

Ren

al fa

ilure

Lupu

s-lik

e sy

ndro

me

DR

UG

INT

ERA

CT

ION

S:

anti

diab

etic↓

bs

benz

odia

zepi

nes ↑

seda

tion

ETO

H↑

into

xica

tion

Nal

oxon

e/na

ltre

xone

↑yo

him

bine

tox

icit

y,

alte

r op

ioid

wit

hdra

wal

sx

CN

S st

imul

ants↑

effe

ct

Ant

icoa

gula

nts ↑

blee

ding

Cen

tral

sym

path

omim

etic

s ↑

yohi

mbi

ne t

oxic

ity

Som

e pr

oduc

ts c

onta

in

very

litt

le y

ohim

be

Bar

k us

ed in

cap

sule

s,

tabl

ets,

tea

Stan

dard

ized

yoh

imbe

av

aila

ble

by p

resc

ript

ion

Dos

e: 5

-50

mg

in

divi

ded

dose

s fo

r

erec

tile

dys

func

tion

Mon

itor

BP,

HR

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Aci

doph

ilus

◆◆

Mai

n ty

pes:

lact

obac

illus

spe

cies

(a

cido

philu

s, c

asei

, pla

ntar

um,

delb

ruec

kii)

◆◆

Bifi

doba

cter

ium

spe

cies

(br

evis

, in

fant

is, l

ongu

m)

Mai

ntai

n or

res

tore

mic

robi

al b

alan

ce

in G

I and

GU

tra

cts;

may

pro

duce

bac

teri

ocin

s an

d

lact

ic a

cid

whi

ch im

pair

gro

wth

of

pat

hoge

ns

* may

cau

se m

orbi

dity

or

mor

talit

y if

pati

ents

im

mun

ocom

prom

ised

or

debi

litat

ed.

Avo

id in

PR

EGN

AN

CY

(ris

k am

nion

itis

, se

psis

,end

omet

riti

s)

Avo

id w

ith

arti

ficia

l hea

rt v

alve

s, r

adia

tion

the

rapy

, or

al s

urge

ry, G

I sur

gery

, hem

e+ d

iarr

hea,

imm

uno-

com

prom

ised

, deb

ilita

ted

dosa

ge v

arie

s de

pend

ing

on n

umbe

r of

livi

ng o

rgan

-is

ms

in p

rodu

ct

som

e yo

gurt

s w

ith

liv

e cu

ltur

es

liqui

ds, c

apsu

les,

pow

ders

, ta

blet

s, m

ilk, v

agin

al a

nd

anal

sup

posi

tori

es

Som

e ar

e ke

pt r

efri

gera

ted

Take

2 h

ours

aft

er

anti

biot

ics

Do

not

take

wit

h im

mun

o-su

ppre

ssan

ts

Alp

ha L

ipoi

c A

cid

(ALA

)◆

◆Fo

und

espe

cial

ly in

pot

atoe

s,

spin

ach,

live

r an

d br

occo

li

Dia

bete

s m

ellit

us, c

atar

acts

, re

tino

path

y, p

erip

hera

l neu

ropa

thy,

an

d ne

phro

path

y fr

om D

M

HIV

, cir

rhos

is, g

lauc

oma

Lead

tox

icit

y

Isch

emic

inju

ry li

ver,

bra

in, h

eart

Bur

ning

mou

th s

yndr

ome

AC

TIO

N: I

MPR

OV

ES

MIC

RO

CIR

CU

LATI

ON

IN

PER

IPH

ERA

L N

EUR

OPA

THY

IN

DM

AC

TIO

N: A

NTI

OXI

DA

NT

AC

TIO

N: ↑

INSU

LIN

-STI

MU

LATE

D

GLU

CO

SE U

SE IN

DM

AC

TIO

N: ↑

CD

4 A

ND

CD

8 LE

VEL

S IN

HIV

* avo

id in

thi

amin

e de

ficie

ncy

(alc

ohol

ism

esp

ecia

lly)

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

Cau

tion

wit

h bl

eedi

ng d

isor

ders

Inte

ract

ions

wit

h an

tico

agul

ants

, ant

ipla

tele

ts,

NSA

IDs/

ASA

may

↑bl

eedi

ng r

isk

May

↓ e

ffec

tive

ness

che

mot

hera

py

May

↓ b

lood

sug

ar a

nd w

orse

n hy

pogl

ycem

ia

Ver

tigo

, h/a

, N/V

, ras

h

Ora

l

IV

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Arg

inin

e◆

◆Se

mi-e

ssen

tial

am

ino

acid

◆◆

Espe

cial

ly in

cor

n, d

airy

, oat

s,

mea

t, g

rain

s, b

row

n ri

ce, n

uts,

ch

ocol

ate,

rai

sins

AC

TIO

N: P

REC

UR

SOR

OF

NIT

RIC

O

XID

E, A

VA

SOD

ILA

TOR

AC

TIO

N: ↑

REL

AXA

TIO

N O

F SM

OO

TH M

USC

LE

AC

TIO

N: ↓

WB

C A

DH

ESIO

N,

PLA

TELE

T A

GG

REG

ATI

ON

, FI

BR

IN F

OR

MA

TIO

N

IMM

UN

E ST

IMU

LAN

T

CA

D, C

HF,

HTN

, PV

D, h

yper

-lip

idem

ia, b

reas

t ca

ncer

, ast

hma

*AN

AP

HYL

AX

IS T

O IV

AR

GIN

INE

IN C

HIL

DR

EN;

*AT

RIO

VEN

TR

ICU

LAR

BLO

CK

h/a,

diz

zine

ss, a

typi

cal c

hest

pai

n

↑ b

leed

ing

risk

↑ o

r ↓

blo

od s

ugar

↓bp

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

Avo

id a

fter

acu

te M

I

Avo

id IV

form

s in

aci

dosi

s or

hyp

oten

sion

Suff

icie

nt a

mou

nts

mad

e in

bod

y

If s

uppl

emen

ted,

cre

am,

caps

ule,

IV, n

utri

ent

bar

No

esta

blis

hed

stan

dard

s

Bee

Pol

len

◆◆

Flow

er p

olle

n co

llect

ed o

n bo

dies

of

wor

ker

bees

mix

ed w

ith

nect

ar

and

bee

saliv

a◆

◆C

omm

erci

al b

ee p

olle

n m

ay b

e ju

st

polle

n ha

rves

ted

from

pla

nts

◆◆

NO

T sa

me

as h

oney

or

roya

l jel

ly◆

◆C

onta

ins:

ess

enti

al a

min

o ac

ids,

es

sent

ial f

atty

aci

ds, h

orm

ones

, m

iner

als,

vit

amin

s B

and

C c

oen-

zym

es, s

tero

ls, l

ipid

s, c

arbo

hy-

drat

es, a

nd m

ore

Ath

leti

c pe

rfor

man

ce

Mem

ory

boos

ter

Mul

tipl

e sc

lero

sis

Men

opau

se a

nd P

MS

Red

uce

canc

er c

hem

othe

rapy

si

de e

ffec

ts

Ant

ioxi

dant

Imm

une

stim

ulan

t

Ant

ifung

al

* Alle

rgic

rea

ctio

ns: a

naph

ylax

is, e

dem

a,

shor

tnes

s of

bre

ath,

pru

ruti

s, e

osin

ophi

lia,

risk

ast

hma

exac

erba

tion

AD

Rs:

N/V

/D, a

bdom

inal

pai

n

Hep

atit

is

H/A

, mal

aise

Phot

osen

siti

vity

Ver

tigo

Hay

feve

r

Dec

reas

ed m

emor

y

Avo

id in

pre

gnan

cy/l

acta

tion

Con

trai

ndic

ated

in a

llerg

y to

pol

lens

Cap

sule

s, t

able

ts, l

iqui

d,

gran

ules

, ext

ract

s, fo

od

supp

lem

ents

No

stan

dard

ized

pro

duct

s

Oft

en in

com

bina

tion

pr

oduc

ts

Polle

n co

nten

t va

ries

de

pend

ing

on p

lant

and

ge

ogra

phic

loca

tion

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Cap

sicu

m “

caye

nne”

“ch

ili p

eppe

r”

“pap

rika

” “c

apsa

icin

”◆

◆Po

ssib

ly c

apsa

icin

rel

ease

s su

b-st

ance

P fr

om n

euro

ns, w

hich

de

crea

ses

pain

sen

sati

on

Use

s: c

lott

ing

diso

rder

s

GI d

isor

ders

Clu

ster

hea

dach

e

Mus

culo

skel

etal

pai

n

Neu

ropa

thic

pai

n

Post

oper

ativ

e N

/V

Pere

nnia

l rhi

niti

s

May

be

imm

unos

uppr

essa

nt,

anti

-infla

mm

ator

y, a

ntim

icro

bial

* ris

k al

lerg

ic r

eact

ions

AD

Rs:

↑H

R, ↑

BP

tran

sien

tly

Topi

cal b

urni

ng o

n sk

in, c

onta

ct d

erm

atit

is

Phar

yngi

tis,

rhi

norr

hea

(nas

al)

Eye

burn

ing

and

tear

ing

Swea

ting

, flu

shin

g

DR

UG

INT

ERA

CT

ION

S

AC

E in

hibi

tors

↑co

ugh

Ant

iarr

hyth

mic

s ↑

HR

Ant

icoa

gula

nts ↑

blee

ding

Ant

idia

beti

c ag

ents

↓bs

,↑in

sulin

Ant

iulc

er a

gent

s ↑

stom

ach

acid

Pow

der,

top

ical

cre

ams,

in

tran

asal

spr

ay

Zost

rix

crea

m c

onta

ins

0,02

5% c

apsa

icin

Law

enf

orce

men

t us

es in

pe

pper

spr

ay

Cho

ndro

itin

Sul

fate

◆◆

Glu

curo

nic

acid

and

gal

acto

sam

ine

mol

ecul

e◆

◆Fo

und

in m

amm

alia

n ca

rtila

ge,

supp

lem

ent

deri

ved

from

bov

ine,

sh

ark,

or

synt

heti

c m

ater

ial

◆◆

Cau

tion

wit

h bo

vine

typ

e: r

isk

bovi

ne s

pong

iform

enc

epha

lopa

thy

(Mad

Cow

Dis

ease

)

Use

s:

Ost

eoar

thri

tis,

esp

ecia

lly o

f hip

an

d kn

ee

Psor

iasi

s

May

hav

e an

ti-in

flam

mat

ory

May

be

prot

ecti

ve o

f joi

nt

* avo

id in

she

llfis

h al

lerg

y

* avo

id in

ble

edin

g di

sord

er, p

reop

erat

ivel

y

AD

Rs:

↑or↓

BP

Euph

oria

, H/A

Ast

hma

exac

erba

tion

Ble

edin

g ri

sk, ↓

hem

oglo

bin

DR

UG

INT

ERA

CT

ION

S

anti

coag

ulan

ts↑

blee

ding

Iron

↑ab

sorp

tion

In c

apsu

les

or c

ombi

ned

wit

h gl

ucos

amin

e

May

be

able

to

dose

in

term

itte

ntly

200-

400m

g/d

in d

ivid

ed

or o

ne d

ose

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Cha

steb

erry

“vi

tex”

◆◆

Use

d by

mon

ks t

o de

crea

se s

exua

l de

sire

, tho

ught

to

prom

ote

chas

tity

Use

s: m

enop

ause

sym

ptom

s

Bre

ast

milk

pro

duct

ion

PMS

sym

ptom

s

Infe

rtili

ty

Acn

e

Stud

ies:

pos

sibl

e be

nefit

for

brea

st

pain

, inf

erti

lity,

PM

S, b

ut n

eeds

m

ore

stud

y

* Do

not

take

in p

regn

ancy

/la

ctat

ion

seco

ndar

y to

ho

rmon

al e

ffec

t

* Do

not

take

wit

h do

pam

ine

med

icat

ions

(s

ome

anti

psyc

hoti

cs, P

arki

nson

’s d

rugs

)

beca

use

affe

cts

dopa

min

e

* Do

not

take

wit

h or

al c

ontr

acep

tive

s or

hor

mon

e-re

late

d ca

ncer

(e.

g. b

reas

t ca

ncer

)

AD

Rs:

Acn

e

GI s

ympt

oms

Diz

zine

ss

Dep

ress

ion,

fati

gue

DR

UG

INT

ERA

CT

ION

S

Ant

ipsy

chot

ic a

gent

s as

abo

ve

Dop

amin

e ag

ents

as

abov

e

Dry

com

mer

cial

ext

ract

: up

to

40m

g/da

y

Liqu

id c

omm

erci

al e

xtra

ct:

1.8m

l/da

y

Dri

ed fr

uit-

up t

o

600m

g/da

y

Cin

nam

on

From

bar

k of

cin

nam

on t

ree

Man

y va

riet

ies;

Cey

lon

and

Chi

nese

(c

assi

a) c

inna

mon

mos

t co

mm

on

Use

s: d

iabe

tes

mel

litus

Bro

nchi

tis

GI s

ympt

oms,

loss

of a

ppet

ite

Ang

ina,

CA

D

Stud

ies:

lack

ing

supp

ort

* Avo

id c

onsu

min

g la

rge

amou

nts

of c

assi

a ci

nnam

on, b

ecau

se it

con

tain

s co

umar

in,

of t

he a

ntic

oagu

lant

fam

ily

* Alle

rgic

/hyp

erse

nsit

ivit

y re

acti

on

AD

Rs:

Ast

hma

Glo

ssit

is, g

ingi

viti

s, s

tom

atit

is

DR

UG

INT

ERA

CT

ION

S

Ant

idia

beti

c ag

ents

↓bs

Pow

ders

, ext

ract

s,

caps

ules

, tea

s

Dos

es: T

ype

II di

abet

es

mel

litus

up

to 6

g/da

y

for

40 d

ays

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Cra

nber

ry◆

◆N

o lo

nger

tho

ught

to

acid

ify u

rine

◆◆

Inst

ead,

con

tain

s pr

oant

ho-

cyan

idin

s w

hich

pre

vent

ba

cter

ial a

dhes

ion

in b

ladd

er

Use

s: t

reat

uri

nary

tra

ct in

fect

ions

Trea

t H

.pyl

ori s

tom

ach

infe

ctio

ns

that

cau

se u

lcer

s

Ant

ioxi

dant

Ant

ican

cer

Prev

ent

dent

al p

laqu

e

Stud

ies:

dis

pute

tha

t cr

anbe

rrie

s ca

n tr

eat

urin

ary

trac

t in

fect

ions

, but

the

y m

ay h

elp

PREV

ENT

them

Stud

ies:

may

pre

vent

E.c

oli o

rgan

ism

s fr

om a

dher

ing

in u

rina

ry t

ract

wal

ls

and

may

pre

vent

H.p

ylor

i org

anis

ms

from

sur

vivi

ng in

sto

mac

h

Stud

ies:

pos

sibl

e an

tiox

idan

t pr

oper

-ti

es; p

ossi

bly

prev

ents

den

tal p

laqu

e

* exc

ess

cran

berr

y ju

ice

can

caus

e G

I ups

et

* use

cau

tiou

sly

if ta

king

con

com

itan

t an

tico

agul

ants

or

asp

irin

, or

med

icat

ions

tha

t af

fect

live

r

AD

Rs:

↑ri

sk b

leed

ing

DR

UG

INT

ERA

CT

ION

S

Ant

ibio

tics

–ad

diti

ve

Ant

icoa

gula

nts ↑

blee

ding

Asp

irin

↑ b

leed

ing

Bev

erag

e, s

auce

s

and

jelli

es

Tabl

ets,

cap

sule

s

Dos

e: c

apsu

les

200-

800m

g da

ily in

div

ided

dos

es

Dos

e: ju

ice

cock

tail—

500m

l/da

y

Cre

atin

e◆

◆Pr

oduc

ed in

bod

y fr

om

amin

o ac

ids

◆◆

Stor

ed in

mus

cles

Use

: ath

leti

c pe

rfor

man

ce

enha

ncem

ent

Stud

ies:

con

flict

ing

repo

rts

abou

t po

ssib

le r

enal

dys

func

tion

Stud

ies:

eff

ects

onl

y in

sho

rt d

urat

ion

phys

ical

act

ivit

y

* Avo

id in

bip

olar

, arr

hyth

mia

, DM

AD

Rs:

H/A

, sed

atio

n, s

eizu

res

Arr

hyth

mia

, ede

ma

GI s

ympt

oms

Mus

cle

cram

ping

Agg

ress

ion,

irri

tabi

lity,

man

ia in

bip

olar

, de

pres

sion

, anx

iety

DR

UG

INT

ERA

CT

ION

S:

Ant

iarr

hyth

mic

s ↑

arrh

ythm

ia

Ant

idia

beti

c ag

ents

alt

er b

s

Diu

reti

cs ↑

effe

ct

NSA

IDS ↑

neph

roto

xici

ty

Avo

id w

ith

caff

eine

pr

oduc

ts

Dos

e: u

p to

25g

/dai

ly

by m

outh

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

DH

EA◆

◆Pr

oduc

ed b

y ad

rena

ls, l

iver

, te

stes

, neu

rons

◆◆

Con

vert

ed t

o D

HEA

S-S,

can

be

con

vert

ed t

o es

trog

ens

an

d an

drog

ens

Use

s: a

dren

al in

suff

icie

ncy

Dep

ress

ion

Obe

sity

Incr

ease

str

engt

h

Stud

ies:

No

bene

fit fo

r im

prov

ing

mem

ory

or

for

dise

ases

Ban

ned

subs

tanc

e: b

y N

atio

nal

Col

legi

ate

Ath

leti

c A

ssoc

iati

on

AD

Rs:

Dee

peni

ng v

oice

Arr

hyth

mia

, HTN

GI s

ympt

oms

Agi

tati

on, c

onfu

sion

, dep

ress

ion,

psy

chos

is

Insu

lin r

esis

tanc

e

DR

UG

INT

ERA

CT

ION

S

Ant

ihyp

erte

nsiv

es ↑

bp

Ant

ipsy

chot

ics ↑

man

ia

Lith

ium

↑m

ania

Ant

idia

beti

c ag

ents

↑in

sulin

res

ista

nce

Tabl

ets,

cap

sule

s, c

ream

s

Fish

Oil

“om

ega

3 oi

ls”

DH

A/E

PA◆

◆Fr

om o

ily fi

sh◆

◆C

onta

ins

DH

A o

meg

a 3

fatt

y ac

id

(doc

osah

exae

noic

aci

d) a

nd E

PA

(eic

osap

enta

enoi

c ac

id)

Use

s:

Hyp

ertr

igly

ceri

dem

ia

Prev

enti

on C

AD

May

be

anti

thro

mbo

geni

c

Mild

↓B

P

↓at

hero

scle

roti

c pl

aque

↓tr

igly

ceri

dem

ia

May

be

anti

-arr

hyth

mic

* avo

id in

fish

alle

rgy

* avo

id p

erio

pera

tive

ly d

ue t

o bl

eedi

ng r

isk

* avo

id in

pre

gnan

cy/l

acta

tion

due

to

risk

of

mer

cury

con

tam

inat

ion

* avo

id in

ble

edin

g di

sord

ers

AD

Rs:

↓B

P, ↑

LDL

↑A

lt in

cys

tic

fibro

sis

↑ri

sk m

ania

Fish

y ta

ste,

bel

chin

g

DR

UG

INT

ERA

CT

ION

S

Ant

icoa

gula

nts ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↓

bp

Vit

A a

nd D

may

cau

se t

oxic

ity

wit

h co

d liv

er o

il

Vit

E:↑

ble

edin

g

Dos

e: 2

-4 g

EP

A+D

HA

dai

ly

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se D

rug

Rea

c-ti

ons

or A

DR

s) O

F SU

PP

LEM

ENT

USU

AL

DO

SIN

G O

F

SUP

PLE

MEN

T

Flax

seed

oil/

seed

“l

inse

ed o

il”◆

◆Fl

axse

ed c

onta

ins

ligna

ns,

or p

hyto

estr

ogen

s◆

◆Fl

axse

ed o

il do

es n

ot

cont

ain

any

ligna

ns

Use

s: m

enop

ause

sym

ptom

s

Laxa

tive

Art

hrit

is

Hyp

erlip

idem

ia

Can

cer

Stud

ies:

sug

gest

hel

p lo

wer

lipi

ds if

lip

ids

are

elev

ated

Stud

ies:

sug

gest

alp

ha-li

nole

ic a

cid

(typ

e of

om

ega

3 fa

tty

acid

) co

n-ta

ined

wit

hin

help

s he

art

dise

ase

Stud

ies:

mix

ed r

esul

ts o

n ho

t fla

shes

Stud

ies:

sug

gest

mig

ht r

educ

e so

me

canc

ers’

ris

ks, u

ncle

ar

* Not

for

preg

nanc

y du

e to

ris

k of

spo

ntan

eous

del

iver

y

* Ris

k al

lerg

y, t

ype

I hyp

erse

nsit

ivit

y

AD

Rs:

Seve

re d

iarr

hea

Abd

omin

al p

ain,

bow

el o

bstr

ucti

on

↓pl

atel

et a

ggre

gati

on

↑ t

rigl

ycer

ides

May

aff

ect

sex

horm

ones

DR

UG

INT

ERA

CT

ION

S:

acet

amin

ophe

n↓ab

sorp

tion

anti

coag

ulan

ts ↑

ble

edin

g

anti

diab

etic

age

nts ↑

or ↓

bs

anti

hype

rten

sive

s ↓

bp

furo

sem

ide↓

abso

rpti

on

Flax

seed

oil

is in

liqu

id o

r ca

psul

e fo

rm

Flax

seed

who

le o

r cr

ushe

d ca

n be

mix

ed w

ith

wat

er

or u

sed

wit

h fo

od; a

lso

in

pow

der

form

Take

bot

h se

ed a

nd o

il in

su

ffic

ient

wat

er t

o av

oid

inte

stin

al o

bstr

ucti

on a

nd

cons

tipa

tion

Do

not

take

sam

e ti

me

as a

ny o

ther

med

icat

ions

or

sup

plem

ents

, as

may

de

crea

se a

bsor

ptio

n

Dos

e: o

il up

to

2g/d

aily

Dos

e: p

owde

r/flo

ur u

p to

60

g/da

ily, d

ivid

ed d

oses

w

ith

liqui

d up

to

4 w

eeks

Glu

cosa

min

eU

ses:

ost

eoar

thri

tis,

rh

eum

atoi

d ar

thri

tis

TMJ

Dia

bete

s m

ellit

us

Chr

onic

ven

ous

insu

ffic

ienc

y

Mos

t st

udie

s us

e gl

ucos

amin

e su

lfate

, so

me

wit

h ch

ondr

oiti

n

Coc

hran

e re

view

: sho

ws

good

ev

iden

ce fo

r m

inim

al im

prov

emen

t

in p

ain

of O

/A k

nee/

hip

* Avo

id in

pre

gnan

cy/l

acta

tion

* avo

id w

ith

hx o

f she

llfis

h or

iodi

ne a

llerg

y as

som

e pr

epar

atio

ns fr

om m

arin

e ex

oske

leto

ns

* cau

tion

in D

M-m

ay↑

bs

AD

Rs:

Diz

zine

ss, H

/A, s

omno

lenc

e

↑bp

,↑he

art

rate

, pal

pita

tion

s

GI s

ide

effe

cts

Ast

hma

exac

erba

tion

DR

UG

INT

ERA

CT

ION

S:

Ant

ihyp

erte

nsiv

es ↓

effe

ct

Ant

icoa

gula

nts ↑

blee

ding

Ant

idia

beti

c ag

ents

↓in

sulin

pro

duct

ion

or ↑

insu

lin r

esis

tanc

e

Take

s av

erag

e 2-

4 w

eeks

fo

r be

nefit

Dos

e: 5

00m

g ti

d fo

r up

to

6 m

onth

s

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Gra

pese

ed E

xtra

ct◆

◆Le

aves

and

frui

t of

gra

pes

ha

ve b

een

used

med

icin

ally

si

nce

anci

ent

Gre

ece

◆◆

Extr

act

mad

e fr

om g

rape

see

ds

left

over

from

win

e-m

akin

g

Use

s: a

ther

oscl

eros

is, C

AD

Hyp

erlip

idem

ia

HTN

Cir

cula

tory

issu

es fr

om d

iabe

tes,

in

eye

s (m

acul

ar d

egen

erat

ion

and

vasc

ular

dis

ease

), p

erip

hery

Can

cers

edem

a

Stud

ies:

sho

w e

ffic

acy

for

chro

nic

veno

us in

suff

icie

ncy

and

extr

emit

y ed

ema

Stud

ies:

ben

efit

for

diab

etic

ret

ino-

path

y an

d an

tiox

idan

t ef

fect

s

Stud

ies

in p

roce

ss a

re lo

okin

g at

br

east

, pro

stat

e, c

olon

can

cer

prev

en-

tion

, Alz

heim

er’s

tre

atm

ent

* Avo

id in

per

iope

rati

ve p

erio

ds

* Avo

id in

pre

gnan

cy/l

acta

tion

* Avo

id w

ith

blee

ding

dis

orde

rs, i

ron

defic

ienc

y

AD

Rs:

H/A

, diz

zine

ss

HTN

Itch

y sc

alp

GI s

ympt

oms

DR

UG

INT

ERA

CT

ION

S:

Ant

icoa

gula

nts ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↑

effe

ct

Ant

idia

beti

c ag

ents

↓bs

Iron

↓ a

mou

nt

Dos

e: u

p to

300

mg/

d

by m

outh

in c

apsu

les

or

tab

lets

Gre

en T

ea “

Chi

nese

Tea

“Jap

anes

e Te

a”◆

◆A

ctiv

e in

gred

ient

is E

GC

G

Use

s: m

enta

l ale

rtne

ss

Wei

ght

loss

Hyp

erlip

idem

ia

Can

cer

trea

tmen

ts—

gast

ric,

br

east

, ski

n

Stud

ies:

mix

ed r

esul

ts o

n pr

even

tion

or

slo

win

g of

som

e ca

ncer

s

Stud

y: im

prov

es m

enta

l ale

rtne

ss,

likel

y fr

om c

affe

ine

* Avo

id if

on

anti

coag

ulan

ts a

s co

ntai

ns V

itam

in K

* Avo

id if

caf

fein

e-se

nsit

ive

* Avo

id u

sing

con

cent

rate

d gr

een

tea

extr

acts

if h

ave

or d

evel

op li

ver

issu

es; s

ome

risk

live

r to

xici

ty

AD

Rs:

Caf

fein

e-re

late

d: in

som

nia,

irri

tabi

lity,

pal

pita

tion

s,

GI u

pset

, uri

nary

freq

uenc

y, ↑

psyc

hiat

ric

sym

ptom

s

Prim

arily

use

d as

be

vera

ge b

y st

eam

ing

gr

een

tea

leav

es.

Can

be

mad

e in

to c

apsu

les

or p

ut w

ith

othe

r pr

oduc

ts.

Som

e to

pica

l pro

duct

s.

Dos

e: 2

50-9

50m

l tea

po

qd

up t

o 4

wee

ks fo

r C

AD

ben

efit

s

Dos

e: 4

00m

l tid

for

m

enta

l ale

rtne

ss

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Gua

rana

◆◆

Has

am

ong

high

est

caff

eine

co

nten

t of

all

plan

ts◆

◆G

uara

na=2

.5%

-7%

caf

fein

e◆

◆C

offe

e=1%

-2%

caf

fein

e

Use

s: c

ogni

tive

and

m

ood

enha

ncem

ent

obes

ity

* Not

to

be u

sed

in p

regn

ancy

/lac

tati

on d

ue t

o hi

gh

perc

enta

ge o

f caf

fein

e an

d as

soci

ated

ris

ks m

isca

r-ri

age,

IUG

R

* not

to

be u

sed

wit

h an

tico

agul

ants

, as

it d

ecre

ases

pl

atel

et a

ggre

gati

on

AD

Rs:

Rel

ated

to

caff

eine

con

tent

Agi

tati

on, a

nxie

ty, i

nsom

nia

Arr

hyth

mia

, hyp

erte

nsio

n

H/A

, GI s

ympt

oms

Tach

ycar

dia,

psy

chos

is, o

ther

s

↓pl

atel

et a

ggre

gati

on

DR

UG

INT

ERA

CT

ION

S:

Alc

ohol

↑ef

fect

Ana

lges

ics ↑

effe

ct

Ant

icoa

gula

nts ↑

blee

ding

anti

hype

rten

sive

s↓ef

fect

anti

biot

ics

alte

r ef

fect

CN

S de

pres

sant

s-an

tago

nist

ic

Ephe

drin

e-ad

diti

ve

Dop

amin

ergi

c-ad

diti

ve

Bet

ablo

cker

s-an

tago

nist

ic

othe

rs

Dry

ext

ract

dos

es s

houl

d no

t be

>3g

/day

Foun

d in

Bra

zilia

n so

das,

an

d in

crea

sing

ly in

US

ener

gy p

rodu

cts

and

en

ergy

dri

nks.

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Kel

p “s

eaw

eed”

◆◆

Bro

wn

seaw

eed

has

been

use

d fo

r fo

od a

nd m

edic

ine

◆◆

Con

tain

s so

dium

alg

inat

e

Use

s: a

ntic

oagu

lant

Ant

ivir

al

Wou

nd r

epai

r

goit

er

Wei

ght

loss

Can

cer

Evid

ence

ant

ioxi

dant

and

an

tiba

cter

ial a

ctio

ns

Ant

icoa

gula

nt e

ffec

t in

lab

* Iod

ine

may

cau

se h

yper

sens

itiv

ity

rash

incl

udin

g an

gioe

dem

a, T

TP, d

eath

* Not

for

preg

nanc

y/la

ctat

ion-

abor

tifa

cent

eff

ect

AD

Rs:

↓bp

in s

ome

spec

ies

Incr

ease

or

decr

ease

thy

roid

Laxa

tive

eff

ect

Ble

edin

g

Peri

pher

al n

euro

path

y fr

om a

rsen

ic c

onte

nt

Nep

hrot

oxic

ity

DR

UG

INT

ERA

CT

ION

SLa

xati

ves ↑

effe

ct

Ant

idia

beti

c ag

ents

↓bs

Ant

icoa

gula

nts ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↓

bp in

som

e

Estr

ogen

s-an

ties

trog

enic

eff

ect

Aqu

eous

ext

ract

, pow

der,

gr

anul

es, c

apsu

les,

tab

lets

No

stan

dard

izat

ion

of

iodi

ne c

onte

nt

Mel

aton

in

Neu

roho

rmon

e se

cret

ed b

y pi

neal

gl

and

due

to d

arkn

ess

Influ

ence

s ci

rcad

ian

rhyt

hm a

nd

slee

p in

itia

tion

Use

: sle

ep d

isor

ders

AD

HD

Alz

heim

er’s

dis

ease

May

impa

ct b

rain

sle

ep c

ente

r

Imm

une

stim

ulan

t

Ant

ioxi

dant

Jet

lag

* Do

not

use

in p

regn

ancy

/lac

tati

on

AD

Rs:

con

fusi

on

Dep

ress

ion

(tra

nsie

nt)

Diz

zine

ss

Dre

am d

istu

rban

ce

Dro

wsi

ness

Irri

tabi

lity

Neu

robe

havi

oral

alt

erat

ion

DR

UG

INT

ERA

CT

ION

SA

ntic

oagu

lant

s ↓

effe

ctiv

enes

s

Ant

ihyp

erlip

idem

ics ↑

athe

rosc

lero

sis

Ant

isei

zure

dru

gs ↑

seiz

ure

risk

Seda

tive

s ↑

seda

tion

Not

app

rove

d fo

r sa

fety

ov

er >

3 m

onth

s us

e

Dos

e: 0

.1-5

mg

in

eve

ning

po

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Pol

icos

anol

◆◆

Alc

ohol

s fr

om s

ugar

can

e w

ax

Use

: hyp

erch

oles

tero

lem

ia

Inhi

bits

cho

lest

erol

syn

thes

is in

live

r

LDL

degr

adat

ion

Ant

ioxi

dant

Stud

ies:

man

y fr

om C

uba,

sou

rce

of

suga

r ca

ne, s

ome

conf

licti

ng d

ata

from

non

-Cub

an s

tudi

es

AD

Rs

Ant

ipla

tele

t ef

fect

H/A

, diz

zy, ↓

BP

DR

UG

INT

ERA

CT

ION

S

Ant

idia

beti

c ag

ents↓

bs

Ant

ihyp

erte

nsiv

es ↓

bp

Ant

ipar

kins

onia

ns ↑

dysk

ines

ias

Ant

icoa

gula

nts ↑

blee

ding

Nit

rate

s ↓

bp

Cap

sule

s, t

able

ts

Dos

e: 5

-80m

g/da

y up

to

3 ye

ars

Red

Yea

st R

ice

◆◆

Extr

act

from

ferm

enti

ng r

ice

w

ith

yeas

t◆

◆FD

A b

anne

d sa

le in

US

due

to

viol

atio

n, s

uppl

emen

t co

ntai

ned

lova

stat

in (

pres

crip

tion

sta

tin)

◆◆

FDA

war

ns n

ot t

o bu

y on

inte

rnet

du

e to

lova

stat

in c

ompo

nent

Use

: hyp

erlip

idem

ia

Con

tain

ste

rols

, fat

ty a

cids

, is

ofla

vone

s

Ant

i-inf

lam

mat

ory

pote

ntia

l

* avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs

Ras

h, a

naph

ylax

is

Diz

zine

ss, H

/A,

↓bp

↓bs

GI s

ympt

oms

↓H

gb, ↓

BU

N

DR

UG

INT

ERA

CT

ION

S

Alc

ohol

↑liv

er t

oxic

ity

CoQ

10 ↓

, nee

ds s

uppl

emen

t

Ant

idia

beti

c ↓

or ↑

bs

Ant

ihyp

erlip

idem

ics ↑

risk

adv

erse

eff

ects

Stat

ins ↑

ris

k ad

vers

e ef

fect

s

↑ri

sk r

habd

omyo

lysi

s w

ith

azal

ides

, cyc

losp

orin

e,

nefa

zodo

ne, o

ther

s

Gel

cap

sule

s

Do

not

take

wit

h gr

apef

ruit

ju

ice

or a

lcoh

ol

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Soy

◆◆

Soyb

eans

con

tain

isof

lavo

nes,

si

mila

r to

est

roge

n

Use

s: m

enop

ausa

l sym

ptom

s

HTN

Hyp

erlip

idem

ia

Ost

eopo

rosi

s

Bre

ast

and

pros

tate

can

cer

(may

be

now

con

trai

ndic

ated

in b

reas

t ca

ncer

)

Stud

ies:

red

uces

LD

L ch

oles

tero

l

Stud

ies:

red

uces

hot

flas

hes

* Rar

e al

lerg

ies

* Avo

id s

oy in

hor

mon

e-re

late

d ca

ncer

s or

ris

k of

ca

ncer

s (b

reas

t, e

ndom

etri

al, o

vari

an)

AD

Rs:

Mild

GI s

ympt

oms

H/A

DR

UG

INT

ERA

CT

ION

S

Ant

icoa

gula

nts ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↓

bp

Tam

oxife

n in

terf

eres

wit

h ef

fect

s

Estr

ogen

inte

rfer

es w

ith

effe

cts

Soyb

eans

, tof

u, s

oy m

ilk

Pow

ders

, cap

sule

s, s

uppl

e-m

ents

and

nut

riti

on b

ars

Dos

e: 1

0-10

6g p

o bi

d

Dos

e: 2

5 g

soy

daily

for

CA

D r

isk

Spir

ulin

a “b

lue-

gree

n al

gae”

Use

s: d

iabe

tes,

hyp

erlip

idem

ia

Alle

rgic

rhi

niti

s

Wei

ght

loss

* avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

H/A

, N/V

hepa

toto

xici

ty

Dos

e: D

M 1

g p

o bi

d

wit

h m

eals

Dos

e: a

llerg

ic r

hini

tis

1000

-200

0mg

qd

x12

wee

ks

Wild

Yam

Use

s: h

yper

lipid

emia

Men

opau

sal s

ympt

oms

* avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

GI u

pset

, con

tact

der

mat

itis

DR

UG

INT

ERA

CT

ION

S

Ant

idia

beti

c ag

ents

↓bs

Hor

mon

es a

lter

ed e

ffec

ts

Topi

cal-v

agin

al c

ream

s

Cap

sule

s: 2

50m

g 1-

3x/d

ay

n RefeRenCeS:Herbs At A Glance. (2013). NIH National Center

for Complementary and Alternative Medicine retrieved at http://nccam.nih.gov/health/herbs ataglance.htm (Natural Standard Database Web site and Natural Medicines Comprehensive Data-base Web site are resources)

Sanoski, C.A., & Sucich, M.I. (2011). Herbal Notes: A Complementary & Alternative Medicine Pocket Guide. Philadelphia: F.A. Davis.

Ulbright, C. (2011). Davis’ Pocket Guide to Herbs and Sup-plements. Philadelphia: F.A. Davis. (Note: author is founder of Natural Standard Research Collabora-tion and Chief Editor, Journal of Dietary Supplements).