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CHEE 440 1

Tablet Coating

Why coat tablets?

Types of coatings

sugar coating

film coating press coating (compression coating)

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CHEE 440 2

Sugar Coating

stages involved sealing of tablet core

subcoating

smoothing

colouring

polishing

printing

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CHEE 440 3

Film Coating

involves spraying a solution of polymer + pigments +

plasticizers onto a rotated, mixed tablet bed

forms a thin, uniform film on tablet surface

materials

polymers

solvents

plasticizers

colorants

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CHEE 440 4

Film Formation

latex particles dispersed

in aqueous phase

formation of thin film with

water evaporation through film

continuous film

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CHEE 440 5

Coating Process

coating pans

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CHEE 440 6

Coating Process

fluid beds

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Important Processing Parameters

inlet and bed temperatures

relative humidity

atomization air pressure

liquid spray rate

droplet size

drying time

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Coating Problems

picking/chipping

roughness

sticking

film cracking/peeling

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Normal Coating

Description Reconstitutionlevel

Averageweightgain

Application examples

HPMC basedAqueoussystem

11% to 15% 2.5 %

HPMC based

Organicsolventsystem

5% 2.5%

HPMC basedAqueous/OrganicSolvent/

HydroAlcoholicsystem

Aqueous 11%

Organic Solvent5%

Hydro Alcoholic9%

2.5%

PVA basedAqueoussystem

20% to 25% 2.5%

Amoxycillin, Azithromycin, Atenolol,Amlodipine, Amitriptyline, AmpicilinCiprofloxacin, Cephadroxil ,Cimitidine, Calcium Tablets, Citrizine, Chloroquine Phosphate,

Clarithromycin, Erythromycin,Ferrous Fumarate, Famotidine,Ferrous Sulphate, Ibuprofen,Indapamine, Losartan Potassium,Levamisole, Methyl-Dopa,Metronidazole+Tinidazole,Metronidazole, Methyl Coblamine,Mefenamic Acid, Metoprolol Tartrate,

Norfloxacin, Nifidipine,Norfloxacin+Tinidazole, Ofloxacin,Paracetamol, Quinine Sulphate,Roxythromycin, Secnidazole,Sildenafil Citrate, Trimetazidine,Tinidazole, Tinidazole-Doxycycline,Tinidazole + Tetracycline, Verapamil

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Enteric-coated

coating resists dissolution or disruption in stomach

but not in intestines

used for drugs that are unstable, irritating to

stomach

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Enteric Coating

DescriptionReconstitutionlevel

Averageweightgain

Application ** examples

Organic EntericCoating system,Cellulose Acetate

Phthalate based

5 % 8 %

Aqueous coatingsystem & Organicenteric coatingsystem. HydroxyPropyl MethylCellulose Phthalatebased system.

Organic: 5%Aqueous: 10%

8 %

Methacrylic acidcopolymer type "C"USP/NF basedsystem

Aqueous 20%

Hydro Alcoholic10%

Organic System10%

9%

Aspirin, Bisacodyl

Diclofenac Sodium

Doxylamine Succinate

Garlic Tablets, Omeprazol,

Pentaprazole,

Pentoxyfyline, Rabeprazol ,

Serrosipeptadise

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Press Coating

use of compression to form coat around a pre-formed core

used mainly to separate chemically incompatiblematerials

also dual release patterns possible