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CHEE 440 1
Tablet Coating
Why coat tablets?
Types of coatings
sugar coating
film coating press coating (compression coating)
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CHEE 440 2
Sugar Coating
stages involved sealing of tablet core
subcoating
smoothing
colouring
polishing
printing
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CHEE 440 3
Film Coating
involves spraying a solution of polymer + pigments +
plasticizers onto a rotated, mixed tablet bed
forms a thin, uniform film on tablet surface
materials
polymers
solvents
plasticizers
colorants
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CHEE 440 4
Film Formation
latex particles dispersed
in aqueous phase
formation of thin film with
water evaporation through film
continuous film
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CHEE 440 5
Coating Process
coating pans
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CHEE 440 6
Coating Process
fluid beds
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Important Processing Parameters
inlet and bed temperatures
relative humidity
atomization air pressure
liquid spray rate
droplet size
drying time
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Coating Problems
picking/chipping
roughness
sticking
film cracking/peeling
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Normal Coating
Description Reconstitutionlevel
Averageweightgain
Application examples
HPMC basedAqueoussystem
11% to 15% 2.5 %
HPMC based
Organicsolventsystem
5% 2.5%
HPMC basedAqueous/OrganicSolvent/
HydroAlcoholicsystem
Aqueous 11%
Organic Solvent5%
Hydro Alcoholic9%
2.5%
PVA basedAqueoussystem
20% to 25% 2.5%
Amoxycillin, Azithromycin, Atenolol,Amlodipine, Amitriptyline, AmpicilinCiprofloxacin, Cephadroxil ,Cimitidine, Calcium Tablets, Citrizine, Chloroquine Phosphate,
Clarithromycin, Erythromycin,Ferrous Fumarate, Famotidine,Ferrous Sulphate, Ibuprofen,Indapamine, Losartan Potassium,Levamisole, Methyl-Dopa,Metronidazole+Tinidazole,Metronidazole, Methyl Coblamine,Mefenamic Acid, Metoprolol Tartrate,
Norfloxacin, Nifidipine,Norfloxacin+Tinidazole, Ofloxacin,Paracetamol, Quinine Sulphate,Roxythromycin, Secnidazole,Sildenafil Citrate, Trimetazidine,Tinidazole, Tinidazole-Doxycycline,Tinidazole + Tetracycline, Verapamil
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Enteric-coated
coating resists dissolution or disruption in stomach
but not in intestines
used for drugs that are unstable, irritating to
stomach
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Enteric Coating
DescriptionReconstitutionlevel
Averageweightgain
Application ** examples
Organic EntericCoating system,Cellulose Acetate
Phthalate based
5 % 8 %
Aqueous coatingsystem & Organicenteric coatingsystem. HydroxyPropyl MethylCellulose Phthalatebased system.
Organic: 5%Aqueous: 10%
8 %
Methacrylic acidcopolymer type "C"USP/NF basedsystem
Aqueous 20%
Hydro Alcoholic10%
Organic System10%
9%
Aspirin, Bisacodyl
Diclofenac Sodium
Doxylamine Succinate
Garlic Tablets, Omeprazol,
Pentaprazole,
Pentoxyfyline, Rabeprazol ,
Serrosipeptadise
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Press Coating
use of compression to form coat around a pre-formed core
used mainly to separate chemically incompatiblematerials
also dual release patterns possible