synthesis of 5-acylindoles via regioselective acylation of 3-trifluoroacetylindole

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2003 Indole derivatives Indole derivatives R 0140 Synthesis of 5-Acylindoles via Regioselective Acylation of 3-Trifluoroacetylindole. — Acylation of title compound (I) with carboxylic acid chlorides using AlCl 3 as the catalyst and nitromethane as the solvent results in formation of 5-acylated derivatives (III) with good regioselectivity. Following hydrolysis and decarboxylation leads to 5-acylindoles in a convenient manner. — (LI, J.; LI, B.; CHEN, X.; ZHANG*, G.; Synlett 2003, 10, 1447-1450; Chengdu Inst. Biol., Chin. Acad. Sci., Chengdu 610041, Peop. Rep. China; Eng.) — Mais 50- 113

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Page 1: Synthesis of 5-Acylindoles via Regioselective Acylation of 3-Trifluoroacetylindole

2003 Indole derivatives

Indole derivativesR 0140 Synthesis of 5-Acylindoles via Regioselective Acylation of 3-Trifluoroacetylindole.

— Acylation of title compound (I) with carboxylic acid chlorides using AlCl3 as the catalyst and nitromethane as the solvent results in formation of 5-acylated derivatives (III) with good regioselectivity. Following hydrolysis and decarboxylation leads to 5-acylindoles in a convenient manner. — (LI, J.; LI, B.; CHEN, X.; ZHANG*, G.; Synlett 2003, 10, 1447-1450; Chengdu Inst. Biol., Chin. Acad. Sci., Chengdu 610041, Peop. Rep. China; Eng.) — Mais

50- 113

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