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  • Swerdlow S et al . Blood 2016

  • Hong JY et al Curr opin Oncol 2015

    Epidemiology

  • • Age cutoff

    • Percentage of EBV+ tumor cells

    • Morphologic heterogeneity

  • Hong JY et al Cur opinion in Oncol 2015

    Immunosenescence• The gradual deterioration of the immune system caused by the ageing process• Continuous remodeling process of immune system

    (not just decline of immune function): decrease of B-cell diversity & increase of clonal expansions of B-cells: decrease of CD4+/CD8+ T cell counts

  • Swerdlow S et al . Blood 2016

  • Hong JY et al. Ann Oncol 2015

  • EBV+ large B-cell lymphoma in young patients

    Nicolae A et al Blood 2015

  • Hong JY et al Cur opinion in Oncol 2015

  • EBV+ large B-cell lymphoma

    Nicolae A et al Blood 2015

  • Study of Ibrutinib in Combination With Rituximab-CHOP in

    Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma

    Brentuximab Vedotin + Rituximab as Frontline Therapy for

    Pts w/ CD30+ and/or EBV+ Lymphomas

    Cellular Immunotherapy for Viral Induced Cancer - EBV

    Positive Lymphomas (CIVIC)

    Study Of Durvalumab and Lenalidomide In R/R EBV

    Associated DLBCL Subtypes, Primary CNS And Testicular

    DLBCL

  • Kataoka K et al. Leukemia 2018

  • Kataoka K et al. Leukemia 2018

  • Kim SJ et al . Cancer Res and Tx 2018

  • SMC lymphoma teams

    CISL members