supplementary materials for...published 17 july 2013, sci. transl. med. 5, 194ra93 (2013) doi:...
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www.sciencetranslationalmedicine.org/cgi/content/full/5/194/194ra93/DC1
Supplementary Materials for
Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry
Júlia Balog, László Sasi-Szabó, James Kinross, Matthew R. Lewis, Laura J. Muirhead,
Kirill Veselkov, Reza Mirnezami, Balázs Dezsı, László Damjanovich, Ara Darzi, Jeremy K. Nicholson,* Zoltán Takáts*
*Corresponding author. E-mail: [email protected] (Z.T.); [email protected] (J.K.N.)
Published 17 July 2013, Sci. Transl. Med. 5, 194ra93 (2013)
DOI: 10.1126/scitranslmed.3005623
The PDF file includes:
Methods Fig. S1. Schematic of intraoperative tissue identification using the iKnife. Fig. S2. Statistical analysis of brain tissue data acquired in vivo and ex vivo. Table S1. Patient cases where preoperative and postoperative histology results did not match. Table S2. Histology-based diagnosis data for all patients recruited into the study (N = 393).
SUPPLEMENTARY METHODS
Instrumentation
Two LCQ Deca XP Plus quadrupole ion trap mass spectrometers (Thermo Finnigan) were used
as mass analyzer units. The instruments (without factory chassis) were installed into noise-
insulating housing made of welded steel housing and stainless steel walls. The walls were lined
with 50 mm thick polyurethane-based insulating material. The exhaust from the air cooling and
vacuum pumps of the instrument was vented to the operating room atmosphere through a 500
mm × 350 mm HEPA filter to avoid the emission of infectious agents. In order to increase the
lifetime of the HEPA filter, another dust filter was used at the cooling air intake of instrument.
Overall noise emission of instrument was decreased to 67 dB, while the operating temperature of
the instrument did not exceed 55 C. All accessories of the mass spectrometer including rotary
vane pumps and helium tank were incorporated into the housing. The atmospheric interface of
instrument was re-built and was optionally equipped with a Venturi air jet pump-based ion
transfer apparatus. The interface and ion transfer device are depicted on Fig. 1A. The Venturi
pump was driven by pressurized air (from the central pressurized air system of the hospital) at
nominal inlet pressure of 4 bars.
Electrosurgical handpieces were coupled to mass spectrometric instrumentation by means
of an aerosol (“smoke”) evacuation tube (Fig. 1) (14, 16). Aerosol formed during electrosurgical
tissue dissection or coagulation was directly and continuously sampled by the handpiece in both
monopolar and bipolar electrosurgery applications. Transfer of the aerosol to the distant mass
spectrometer was carried out in two distinctively different ways depending on whether
monopolar or bipolar electrosurgery was used. In the case of monopolar electrosurgery, the
aerosol is transferred using a Venturi pump (Fig. 1A) and 4 m long polymer tubing. Since linear
gas velocities in the range of 100-200 m/s are achievable using the described setup, desorbed
particles reach the mass spectrometric analyzer within 20-30 ms. When bipolar forceps are used,
the aerosol is directly transferred to the mass analyzer using a polymer tube without the aid of an
air jet pump. A lower rate of ion formation (relative to monopolar electrosurgery) and near
complete absence of interfering combustion products in the aerosol allow for such direct
introduction which is assisted by the suction force induced by the vacuum system of the mass
spectrometer.
The modified electrosurgical handpiece, incorporating ion transfer tubing, was obtained
from Meyer-Haake GmbH. The handpiece was connected to either an Erbotom ICC 300 (Erbe
Elektromedizin GmbH) or a Radiosurg 2200 (Meyer-Haake GmbHy) electrosurgical unit. The
devices were used both in cut and coagulation modes. Laboratory analyses of ex vivo specimens
were carried out using LCQ Deca XP Plus and LTQ-Orbitrap Discovery (Thermo Scientific)
mass spectrometer instruments. Instruments were equipped with modified atmospheric interfaces
featuring heated capillary atmospheric inlet and orthogonal Venturi-pump aerosol transfer
device. During laboratory experiments, a 70 cm long, 1/8” OD, 2 mm ID PTFE tubing was used
for aerosol transfer, connected to a monopolar electrosurgical handpiece, which was functionally
identical to the ones used in the surgical environment. The calculations were performed on a
Lenovo ThinkCentre computer equipped with Intel core 2 Duo CPU at 2.80 GHz and 2 GB of
RAM.
SUPPLEMENTARY FIGURES
Fig. S1. Schematic of intraoperative tissue identification using the iKnife. (A) The MS
instrument in the OR. (B) Resection of liver parenchyma using dedicated electrosurgery
handpiece. (C) H&E staining of tumor–healthy boundary region containing electrosurgical
dissection line. Tissues were analyzed ex vivo. The region in red box is magnified on the right to
show the feasibility of histological identification of dissected issues. (D) Healthy and cancerous
tissue spectra acquired by LCQ Deca XP instrument. Identification is based on histological
results in (C). (E) Pseudo 3-D PCA plot of healthy liver parenchyma and cancerous tissue
analyzed ex vivo. The red dots indicate the real-time spectra during the surgery in OR.
Fig S2. Statistical analysis of brain tissue data acquired in vivo and ex vivo. Data are
individual spectra (n) from healthy and cancerous brain tissue from 30 patients. All healthy
tissue spectra were acquired in vivo. Cancerous tissue spectra were acquired both in vivo and ex
vivo.
SUPPLEMENTARY TABLES
Table S1. Patient cases where preoperative and postoperative histology results did not
match. In 15 cases, pre-operative and post-operative histological diagnoses did not match.
Tissue from these cases were analyzed post-operatively ex vivo with the REIMS-iKnife
approach, looking for both the tissue type and whether or not it was malignant. “Outlier”
represents a sample for which tissue-type could not be recognized because it was not present in
our spectral database (n = 4). WHO column indicates the international classification of each
pathology and is included in the final pathology report in many cases. REIMS-iKnife diagnoses
that were healthy (matching WHO-based assessment) are in italics (n = 9).
Gender Age Pre-operative
diagnosis based on
histology
REIMS-iKnife
post-operative
diagnosis
Histological
diagnosis according
to WHO
Final diagnosis based on post-
operative histopathology
F 71
Malignant neoplasm
of upper lobe,
bronchus or lung
Lungs, healthy Other disorders of
lung
Upper lobe scarring and fibrosis,
with secondary bronchiectasis
M 62 Malignant neoplasm
of sigmoid colon Colon, healthy
Diverticular disease
of large intestine
without perforation
or abscess
Diverticulitis
M 56
Malignant neoplasm
of stomach,
unspecified
Stomach, healthy
Other specified
diseases of stomach
and duodenum
Gastritis
M 45
Malignant neoplasm
of lower lobe,
bronchus or lung
Lungs, healthy Other disorders of
lung
Pneumonia secondary to infarction
of lung
F 53
Malignant neoplasm
of bronchus and lung,
unspecified
Lungs, healthy Other disorders of
lung Pneumonia with fibrotic change
F 67 Malignant neoplasm
of colon Colon, healthy Crohn’s disease
Colonic Crohn’s disease with
terminal ileitis
F 58 Malignant neoplasm
of splenic flexure Outlier
Benign neoplasm of
colon, unspecified
Tubulovillous adenoma of the
colon with low grade dysplasia
M 56
Malignant neoplasm
of lower lobe,
bronchus or lung
Outlier
Tumor of lung with
uncertain malignant
potential
Neuroendocrine tumor
M 69
Unknown neoplasm
trachea, bronchus and
lung
Squamous cell
carcinoma
Malignant neoplasm
of bronchus
unspecified
Squamous cell carcinoma of the
lung
F 45
Malignant neoplasm
of bronchus and lung,
unspecified
Lungs, healthy Abscess of lung,
pneumonia Pneumonia with secondary abscess
F 70 Malignant neoplasm
of the gall bladder Outlier Cholangitis Cholangitis
F 56 Malignant neoplasm
of small intestine
Small intestine,
healthy
Benign neoplasm of
small intestine Benign neoplasm of small intestine
F 48
Malignant neoplasm
of lower lobe,
bronchus or lung
Lungs, healthy Emphysema Emphysema
M 43 Malignant neoplasm
of thorax Outlier
Pseudosarcomatous
fibromatosis
Pseudosarcomatous fibromatosis
(nodular 6asciitis)
M 43
Malignant neoplasm
of lower lobe,
bronchus or lung
Lungs, healthy Benign lung
neoplasm Bronchial chondro-hamartoma
Table S2. Histology-based diagnosis data for all patients recruited into the study ( = 393). G, tumor grade; M, distant metastases; N, lymph node status; T, tumor stage.
N
Patient
number Sex Age
Pre-operative
diagnosis according to
WHO
Post-operative
histological diagnosis
according to WHO
Diagnosis based on post-operative
histopathology
1 M 56 Malignant neoplasm of
middle third oesophagus
Malignant neoplasm of
middle third oesophagus
Oesophogeal ulcerated squamous
cell carcinoma G3, pT3, pN0
2 M 56 Malignant neoplasm of
esophagus
Malignant neoplasm of
esophagus
Oesophageal ulcerated squamous
cell carcinoma G1, pT2, pN0
3 M 70 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Ulcerated diffuse adenocarcinoma
of stomach G3, pT3, pN0
4 F 61 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Ulcerated adenocarcinoma of
stomach G2, pT2a, pN1
5 M 67 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Diffuse adenocarcinoma of stomach
G3, pT3, pN2
6 M 67 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Mixed adenocarcinoma of stomach
G3, pT3a, pN0
7 M 61 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Intestinal type adenocarcinoma of
stomach G3, pT2b, pN1
8 M 58 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Diffuse adenocarcinoma of stomach
G3, pT3, pN1
9 M 67 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Ulcerated adenocarcinoma of
stomach G3, pT3, pN0
10 M 71 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Adenocarcinoma of stomach G2,
pT3, pN0
11 F 71 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Invasive, intestinal type
adenocarcinoma of stomach G3,
pT0, pN0
12 F 64 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Invasive, mixed adenocarcinoma of
stomach G3, pT4, pN1
13 M 75 Malignant neoplasm of
lower third oesophagus
Malignant neoplasm of
stomach
Adenocarcinoma of stomach G2,
pT3, pN2
14 F 73 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Intestinal type adenocarcinoma of
stomach
15 F 76 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Ulcerated, intestinal type
adenocarcinoma of stomach G2,
pT3, pN0
16 M 63 Malignant neoplasm of
lower third oesophagus
Malignant neoplasm of
stomach Diffuse adenocarcinoma of stomach
17 F 82 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Diffuse adenocarcinoma of stomach
G3, pT4, pN1
18 M 73 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Ulcerated adenocarcinoma of
stomach, G2, pT2b, pN1
19 M 72 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Ulcerated, diffuse adenocarcinoma
of stomach G3, pT2b, pN1
20 M 50 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Diffuse adenocarcinoma of stomach
G3, pT3, pN3a
21 M 54 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Mixed adenocarcinoma of stomach
G3, pT1a, pN0
22 M 75 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Mixed adenocarcinoma of stomach
G3, pT3, pN3a
23 M 78 Malignant neoplasm of
stomach
Malignant neoplasm of
stomach
Intestinal type adenocarcinoma of
stomach G2, pT3, pN0
24 M 56 Malignant neoplasm of
stomach
Other specified diseases
of stomach and
duodenum
Gastritis
25 F 56 Malignant neoplasm of
small intestine
Neoplasm of uncertain
or unknown behaviour
of small intestine
Gastrointestinal stromal tumor
with low-grade malignant potential
26 F 76 Malignant neoplasm of
caecum
Malignant neoplasm of
caecum
Ulcerated caecal adenocarcinoma
G3, pT3, pN1
27 F 72 Malignant neoplasm of
caecum
Malignant neoplasm of
caecum
Ulcerated caecal adenocarcinoma
G2, pT3, pN0
28 M 62 Malignant neoplasm of
caecum
Malignant neoplasm of
caecum
Ulcerated mucinous caecal
adenocarcinoma G3, pT3, pN0
29 F 53 Malignant neoplasm of
caecum
Malignant neoplasm of
caecum
Ulcerated, mucinous caecal
adenocarcinoma G3, pT2, pN0
30 M 75 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Synchronous ascending and
transverse colon adenocarcinoma
G3, pT3, pN1c
31 F 72 Malignant neoplasm of
caecum
Malignant neoplasm of
caecum
Ulcerated, mucinous caecal
adenocarcinoma G3, pT2, pN1a.
32 F 74 Malignant neoplasm of
caecum
Malignant neoplasm of
caecum
Caecal adenocarcinoma G3, pT3,
pN0
33 F 81 Malignant neoplasm of
caecum
Malignant neoplasm of
caecum
Ulcerated caecal adenocarcinoma
G2, pT3, pN1b
34 M 34 Malignant neoplasm of
ascending colon
Malignant neoplasm of
ascending colon
Poorly differentiated ulcerated
adenocarcinoma ascending colon
G4, pT3, pN1
35 F 78 Malignant neoplasm of
ascending colon
Malignant neoplasm of
ascending colon
Ulcerated ascending colon
adenocarcinoma G2, pT2, pN0
36 M 80 Malignant neoplasm of
ascending colon
Malignant neoplasm of
ascending colon
Ulcerated ascending colon
adenocarcinoma G2, pT3, pN0
37 M 56 Malignant neoplasm of
ascending colon
Malignant neoplasm of
ascending colon
Ulcerated ascending colon
adenocarcinoma G2, pT3, pN0
38 M 65 Malignant neoplasm of
caecum
Malignant neoplasm of
hepatic flexure
Poorly differentiated ascending
colon adenocarcinoma G3, pT1,
pN1
39 M 65 Malignant neoplasm of
hepatic flexure
Malignant neoplasm of
hepatic flexure
Hepatic flexure adenocarcinoma G2,
pT3, pN0
40 M 67 Malignant neoplasm of
transverse colon
Malignant neoplasm of
transverse colon
Ulcerated transverse colon
adenocarcinoma G2, pT3, pN0
41 M 63 Malignant neoplasm of
transverse colon
Malignant neoplasm of
transverse colon
Caecal adenocarcinoma G2, pT3,
pN0
42 M 67 Malignant neoplasm of
transverse colon
Malignant neoplasm of
transverse colon
Ulcerated transverse colon
adenocarcinoma G2, pT3, pN0
43 F 83 Malignant neoplasm of
splenic flexure
Malignant neoplasm of
splenic flexure
Mucinous adenocarcinoma splenic
flexure G4, pT3, pN2b
44 F 77 Malignant neoplasm of
splenic flexure
Malignant neoplasm of
splenic flexure
Adenocarcinoma of splenic flexure
G3, pT4b, pN1b
45 F 67 Malignant neoplasm of
descending colon
Malignant neoplasm of
descending colon
Ulcerated adenocarcinoma of
descending colon G3, pT3, pN2
46 F 73 Malignant neoplasm of
descending colon
Malignant neoplasm of
descending colon
Ulcerated adenocarcinoma of
descending colon G3, pT3, pN2a
47 M 61 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
sigmoid colon
Adenocarcinoma of sigmoid colon
G3, pT3, pN2a
48 M 64 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
sigmoid colon
Ulcerated sigmoid adenocarcinoma
with cribriform pattern G2, pT3,
pN0
49 M 50 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
sigmoid colon
Ulcerated sigmoid adenocarcinoma
G2, pT3, pN0
50 F 67 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
sigmoid colon
Desmoplastic papillary
adenocarcinoma sigmoid colon G2,
pT3, pN0
51 F 72 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
sigmoid colon
Adenocarcinoma of sigmoid colon
G2, pT3, pN1
52 M 68 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
sigmoid colon
Ulcerated mucinous sigmoid
adenocarcinoma G2, pT3, pN1b
53 M 58 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Rectal adenocarcinoma G2, pT2,
pN0
54 F 71 Neoplasma coli
malignum
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G2, pT3, pN0
55 F 55 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Mucinous poorly differentiated
colonic adenocarcinoma G3, pT2,
pN1
56 M 56 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Ulcerated adenocarcinoma colon
G2, pT4, pN0
57 M 64 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Ulcerated adenocarcinoma of colon
G2, pT2, pN0
58 M 68 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Mucinous ulcerated rectal
adnocarcioma G3 pT3, pN1b
59 M 62 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Rectal adenocarcinoma G2, pT2,
pN0
60 F 66 Malignant neoplasm of
descending colon
Malignant neoplasm of
colon
Colonic adenocarcinoma G2, pT2,
pN0
61 M 72 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
colon
Colonic adenocarcinoma G2, pT3,
pN0
62 M 56 Malignant neoplasm of
ascending colon
Malignant neoplasm of
colon
Caecal adenocarcinoma
G3, pT3, pN0
63 F 82 Malignant neoplasm of
transverse colon
Malignant neoplasm of
colon
Mucinous, ulcerated colonic
adenocarcinoma G3, pT2, pN0
64 M 65 Malignant neoplasm of
ascending colon
Malignant neoplasm of
colon
Invasive colonic adenocarcinoma
G3, pT3, pN0
65 M 69 Malignant neoplasm of
ascending colon
Malignant neoplasm of
colon
Mucinous colonic adenocarcinoma
G3, pT2, pN0
66 F 74 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Ulcerated rectal adenocarcinoma
pT2, pN1
67 M 79 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Rectal adenocarcinoma
G2, pT3, pN1a
68 M 66 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Rectal adenocarcinoma G2, pT2,
pN0
69 F 70 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Mucinous adenocarcinoma
rectosigmoid junction pT3, pN0.
70 M 68 Malignant neoplasm of
colon
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G1, pT3, pN1
71 M 77 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Mucinous adenocarcinoma rectum
G3, pT1, pN2
72 F 77 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
colon
Ulcerated sigmoid
adenocarcinoma.G3, pT2, pN1b
73 M 53 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Necrotic colonic adenocarcinoma
G2, pT3, pN0
74 M 75 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Ulcerated, mucinous rectosigmoid
adenocarcinoma G3, pT3, pN1
75 F 80 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G3, pT3, pN0
76 M 73 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G3, pT3, pN2b
77 F 64 Malignant neoplasm of
colon
Malignant neoplasm of
colon
Sigmoid adenocarcinoma G2, pT4b,
pN0
78 F 79 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
colon
Ulcerated, necrotic colonic
adenocarcinoma G2, pT3, pN0
79 F 57 Malignant neoplasm of
transverse colon
Malignant neoplasm of
colon
Ulcerated, mucinous colonic
adenocarcinoma G2, pT3, pN0
80 M 61 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Ulcerated, necrotic colonic
adenocarcinoma G2, pT3, pN0
81 M 56 Malignant neoplasm of
splenic flexure
Malignant neoplasm of
colon
Ulcerated, necrotic colonic
adenocarcinoma pT4b, pN1b
82 M 49 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Ulcerated, necrotic colonic
adenocarcinoma G3, pT2, pN0
83 M 67 Malignant neoplasm of
colon
Malignant neoplasm of
colon
Ulcerated descending colon
adenocarcinoma G2, pT3, pN0
84 F 62 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Ulcerated rectal adenocarcinoma
G2, pT4b, pN0
85 F 65 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
colon
Ulcerated, necrotic colonic
adenocarcinoma G2, pT3, pN0
86 F 60 Malignant neoplasm of
hepatic flexure
Malignant neoplasm of
colon
Ulcerated mucinous colonic
adenocarcinoma G3, pT3, pN0
87 M 64 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Caecal adenocarcinoma G3, pT4,
pN2
88 M 45 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G2, pT3, pN0
89 M 64 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Ulcerated, necrotic colonic
adenocarcinoma G2, pT2, pN0
90 M 64 Malignant neoplasm of
colon
Malignant neoplasm of
colon
Mucinous ascending colon
adenocarcinoma G2, pT3, pN0
91 M 78 Malignant neoplasm of
hepatic flexure
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G2, pT3, pN0
92 F 54 Malignant neoplasm of
splenic flexure
Malignant neoplasm of
colon
Adenocarcinoma descending colon
G3, pT2, pN0
93 M 62 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Adenocarcinoma descending colon
G3, pT2, pN0
94 M 75 Malignant neoplasm of
hepatic flexure
Malignant neoplasm of
colon Colonic adenocarcinoma pT3, pN0
95 M 61 Malignant neoplasm of
descending colon
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G2, pT2, pN1c
96 M 47 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Ulcerated rectosigmoid
adenocarcinoma G2, pT3, pN1b
97 F 54 Malignant neoplasm of
splenic flexure
Malignant neoplasm of
colon
Mucinous, ulcerated colonic
adenocarcinoma G3, pT3, pN0
98 F 71 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Ulcerated caecal adenocarcinoma
G2, pT2, pN0
99 M 56 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Ulcerated rectal adenocarcinoma
G2, pT2, pN1
100 M 67 Abdominal and pelvic
pain
Malignant neoplasm of
colon
Anaplastic colonic adenocarcinoma,
G3, pT3, pN1c
101 F 49
Neoplasm of uncertain
or unknown behaviour
of colon
Malignant neoplasm of
colon
Rectal adenocarcinoma G2, pT1,
pN1a
102 M 72 Malignant neoplasm of
transverse colon
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G2, pT3, pN0
103 M 69 Malignant neoplasm of
splenic flexure
Malignant neoplasm of
colon
Necrotic, ulcerated colonic
adenocarcinoma G2, pT3, pN1b
104 M 80 Malignant neoplasm of
colon
Malignant neoplasm of
colon
Signet ring cell carcinoma,
descending colon G3, pT3, pN1c
105 F 63 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Sigmoid adenocarcinoma G3, pT3,
pN2b
106 M 77 Malignant neoplasm of
descending colon
Malignant neoplasm of
colon
Colonic adenocarcinoma G2, pT2,
pN0
107 M 71 Malignant neoplasm of
caecum
Malignant neoplasm of
colon Colonic adenocarcinoma G2, pT3
108 M 72 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Necrotic, ulcerated colonic
adenocarcinoma G2, pT2, pN1
109 F 60 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G2, pT3, pN0
110 M 64 Malignant neoplasm of
transverse colon
Malignant neoplasm of
colon
Colonic adenocarcinoma G2, pT2,
pN0
111 F 57 Malignant neoplasm of
colon
Malignant neoplasm of
colon
Ulcerated colonic adenocarcinoma
G2, pT2, pN1
112 M 66 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Colonic adenocarcinoma arising
from adenomatous polyp G2, pTis,
pN0
113 F 88 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
colon
Adenocarcinoma arising from
adenomatous polyp pT2
114 F 51 Malignant neoplasm of
sigmoid colon
Malignant neoplasm of
colon
Ulcerated, mucinous colonic
adenocarcinoma G3, pT4b, pN0
115 F 72 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Recurrent mucinous colonic
adenocarcinoma
116 M 78 Malignant neoplasm of
colon
Malignant neoplasm of
colon
Papillary caecal adenocarcinoma
G2, pT1
117 F 62 Malignant neoplasm of
descending colon
Malignant neoplasm of
colon
Ulcerated sigmoid adenocarcinoma
G2, pT3, pN1
118 M 62 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Necrotic colonic adenocarcinoma
G2
119 M 72 Malignant neoplasm of
ascending colon
Malignant neoplasm of
colon
Ascending colon adenocarcinoma
G3, pT3, pN1
120 M 63 Malignant neoplasm of
splenic flexure
Malignant neoplasm of
colon
Ulcerated, mucinous colonic
adenocarcinoma G3, pT3, pN1b
121 M 79 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Ulcerated, mucinous colonic
adenocarcinoma G3, pT2, pN0
122 M 81 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Poorly differentiated colonic
adenocarcinoma G3, pT3, pN0
123 M 70 Malignant neoplasm of
ascending colon
Malignant neoplasm of
colon
Necrotic, ulcerated colonic
adenocarcinoma G2, pT2, pN1c
124 F 82 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
colon
Ulcerated rectosigmoid
adenocarcinoma G2, pT3, pN1b
125 M 76 Malignant neoplasm of
caecum
Malignant neoplasm of
colon
Caecal adenocarcinoma G3, pT3,
pN0
126 M 45 Malignant neoplasm of
rectum
Malignant neoplasm of
colon
Rectal adenocarcinoma, G2, pT2,
pN0
127 M 68 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Ulcerated colonic adenocarcinoma
G3, pT2, pN0
128 M 83 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Sigmoid adenocarcinoma G2, pT2,
pN0
129 M 72 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Adenocarcinoma arising from
colonic tubulovillous adenoma pT1,
pN0
130 M 74 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Ulcerated rectosigmoid
adenocarcinoma G2, pT3, pN0
131 M 67 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Ulcerated sigmoid adenocarcinoma
G2, pT3, pN0
132 M 75 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Ulcerated rectosigmoid
adenocarcinoma G2, pT3, pN0
133 F 65 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Ulcerated rectal adenocarcinoma
G3, pT3, pN2b
134 M 74 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Ulcerated rectosigmoid
adenocarcinoma G2, pT4a, pN1b
135 F 70 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Sigmoid adenocarcinoma G2, pT4,
pN0
136 F 66 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectosigmoid junction
Ulcerated rectosigmoid
adenocarcinoma G3, pT3, pN1b
137 F 59 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Squamous cell carcinoma in rectum
infiltrating vagina G2, pT4, pN1c
138 M 65 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated rectal adenocarcinoma
G2, pT3, pN0
139 F 46 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated colonic adenocarcinoma
G2, pT2, pN0
140 M 56 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated rectal adenocarcinoma
G2, pT2, pN0
141 M 64 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated, inflammatory rectal
adenocarcinoma G3, pT3
142 M 72 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Rectal adenocarcinoma G2, pT2,
pN1b
143 M 52 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Necrotic rectal adenocarcinoma G2,
pT1, pN1
144 M 58 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated rectal adenocarcinoma
G2, pT3, pN2
145 M 86 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Rectal adenocarcinoma G2, pT2,
pN0
146 M 50 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Rectal adenocarcinoma G2, pT2,
pN1,
147 M 64 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated, mucinous rectal
adenocarcinoma G3, pT3, pN2a
148 M 66 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated, mucinous rectal
adenocarcinoma G3, pT4, pN1c
149 F 77 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Recurrent ulcerated rectal
adenocarcinoma G2, pT4b, pN1c
150 M 51 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum Rectal adenocarcinoma
151 M 46 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated rectal adenocarcinoma
G2, pT2, pN0
152 F 56 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated sigmoid adenocarcinoma
G2, pT3, pN0
153 F 49 Malignant neoplasm of
rectosigmoid junction
Malignant neoplasm of
rectum
Rectal adenocarcinoma G2, pT4b,
pN0
154 M 48 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated rectal adenocarcinoma
G2, pT2, pN0
155 M 70 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated rectosigmoid
adenocarcinoma G3, pT3, pN0
156 M 58 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated rectal adenocarcinoma
G2, pT3, pN1
157 M 71 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Colonic adenocarcinoma G3, pT3,
pN1c
158 M 78 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Rectal adenocarcinoma G3, pT3,
pN2a
159 M 76 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Colonic adenocarcinoma G2, pT2,
pN0
160 F 80 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated colonic adenocarcinoma
G2, pT3, pN0
161 F 67 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Inflammatory adenocarcinoma
arising from rectal polyp G2, pT2,
pN0
162 F 80 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Rectal adenocarcinoma G3, pT3,
pN1c
163 F 54 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Colonic adenocarcinoma G2, pT2,
pN0
164 M 57 Malignant neoplasm of
rectum
Malignant neoplasm of
rectum
Ulcerated rectosigmoid
adenocarcinoma G2, pT3, pN0
165 M 58 Melignant neoplasm of
rectum
Benign neoplasm of
colon
Rectosigmoid tubulovillous
adenoma
with low grade dysplasia
166 F 58 Malignant neoplasm of
splenic flexure
Benign neoplasm of
colon
Colonic tubulovillous adenoma
with low grade dysplasia
167 M 59 Benign neoplasm of
colon
Benign neoplasm of
colon
Colonic tubulovillous adenoma
with low grade dysplasia
168 F 84 Rectal polyp Benign neoplasm of
colon
Colonic tubulovollous adenoma
with low grade dysplasia
169 F 70 Benign neoplasm of
rectum
Benign neoplasm of
colon
Colonic tubulovillous adenoma
with low grade dysplasia
170 M 66 Benign neoplasm of
rectum
Benign neoplasm of
colon
Colonic tubulovillous adenoma
with low grade dysplasia
171 F 82 Benign neoplasm of
ascending colon
Benign neoplasm of
colon
Colonic tubulovillous adenoma
with low grade dysplasia
172 F 33 Crohn’s disease Teminal ileitis Terminal ileitis consistent with
Crohn’s disease
173 M 54 Gastroenteritis and
colitis Crohn’s disease Crohn’s colitis
174 F 67 Malignant neoplasm of
caecum Crohns disease
Granulomatous ileitis consistent
with Crohn’s disease
175 M 25 Crohn’s disease Crohn’s disease Crohn’s colitis
176 F 64 Crohn’s disease Crohn’s disease Crohn’s colitis
177 M 31 Crohn’s disease Crohn’s disease Crohn’s colitis
178 F 32 Crohn’s disease of small
intestine with fistula
Crohn’s disease of small
intestine with fistula
Small bowel inflammation
consistent with Crohn’s disease
179 M 64 Crohn’s disease of small
intestine Crohn’s disease of colon
Inflammatory bowel disease
(Crohn’s disease activity)
180 M 25 Crohn’s disease of colon Crohn’s disease of colon Crohn’s colitis
181 M 53 Ulcerative colitis Ulcerative colitis Ulcerative colitis
182 M 62 Malignant neoplasm of
sigmoid colon
Diverticular disease of
large intestine without
perforation or abscess
Colonic diverticulitis
183 M 67 Malignant neoplasm of
head of pancreas
Malignant neoplasm of
Papilla Vateri
Poorly differentiated
adenocarcinoma of major duodenal
papilla G3, pT3, pNl
184 M 77 Malignant neoplasm of
body of pancreas
Malignant neoplasm of
body of pancreas
Papillary cystadenocarcinoma body
of pancreas G2, pT3, pNX
185 M 54 Malignant neoplasm of
tail of pancreas
Malignant neoplasm of
tail of pancreas
Neuroendocrine carcinoma
pancreas, G3, pT3, pN1
186 M 16 Benign neoplasm of
pancreas
Neoplasm of pancreas
with uncertain
malignancy
Neuroendocrine tumor pancreas G1,
pT2
187 M 69
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Large cell anaplastic carcinoma left
lower lobe lung G3, pT2, pN1
188 F 61
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Squamous cell carcinoma upper
lobe lung G2, pT1b, pN0
189 M 57
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Squamous cell carcinoma upper
lobe right lung G2, pT2a, pN1
190 M 61
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Squamous cell carcinoma upper
lobe left lung G2, pT2, pN0
191 M 74
Malignant neoplasm of
middle lobe, bronchus
or lung
Malignant neoplasm of
middle lobe, bronchus
or lung
Poorly differentiated squamous cell
carcinoma left lung G3, pT1a, pN0
192 F 56
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Squamous cell carcinoma lower
lobe lung G3, pT1, pN0
193 M 57
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Squamous cell carcinoma lower
lobe right lung G2, pT2, pN2
194 F 57
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Poorly differentiated squamous cell
carcinoma lung G3, pT1, pN0
195 M 63 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
bronchus or lung
Squamous cell carcinoma lower
lobe left lung G2, pT1b, pN0
196 M 67
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Squamous cell carcinoma upper
lobe right lung G2, pT2a, pN0
197 F 65 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
bronchus or lung
Squamous cell carcinoma upper
lobe left lung G2, pT2a, pN0
198 M 63
Malignant neoplasm of
middle lobe, bronchus
or lung
Malignant neoplasm of
bronchus or lung
Squamous cell carcinoma lung G2,
pT1b, pN0
199 F 61
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Squamous cell carcinoma upper
lobe right lung G2, pT1a, pN0
200 F 46
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe lung
G2, pT2a, pN0
201 M 63
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe right
lung G3, pT2, pN2
202 F 59
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe right
lung G3, pT1a, pN0
203 F 61
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe lung
G2, pT1, pN0
204 M 54 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Poorly differentiated
adenocarcinoma upper lobe left lung
G3, pT2a, pN1
205 M 68
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe right
lung G2, pT1a, pN0
206 M 71
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe lung
G3, pT1, pN0
207 F 49
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe right
lung G3, pT1a, pN0
208 F 55
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe left
lung G2, pT2a, pN0
209 M 72
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Squamous cell carcinoma upper
lobe right lung G2, pT2, pN0
210 F 51
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Papillary adenocarcinoma upper
lobe left lung G2, pT2, pN2
211 F 64
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe left
lung G3, pT2a, pN0
212 F 74
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe right
lung G2, pT1a, pN0
213 F 57
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe left
lung pT1b, pN0
214 M 65
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe left
lung G2, pT3, pN0
215 F 48
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Bronchioalveolar carcinoma upper
lobe right lung G2, pT1a, pN0
216 F 57
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe right
lung pT1b, pN0
217 F 48
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe left
lung G2, pT2, pN0
218 M 70
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma lung G2, pT1b,
pN0
219 M 56
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenocarcinoma upper lobe left
lung G2, pT1b, pN0
220 F 60
Malignant neoplasm of
middle lobe, bronchus
or lung
Malignant neoplasm of
middle lobe, bronchus
or lung
Adenocarcinoma middle lobe right
lung G3, pT2a, pN0
221 F 33
Malignant neoplasm of
middle lobe, bronchus
or lung
Malignant neoplasm of
middle lobe, bronchus
or lung
Adenocarcinoma middle lobe right
lung G2, pT1a, pN0
222 M 68
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Adenocarcinoma lower lobe lung
G3, pT2a, pN1
223 F 54
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Adenocarcinoma (partially necrotic)
lower lobe right lung G3, pT1b,
pN1
224 F 54
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Mucinous papillary adenocarcinoma
lower lobe right lung G2, pT2a,pN0
225 F 66
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Adenocarcinoma lower lobe left
lung G2, pT1b, pN0
226 M 65
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Adenocarcinoma lower lobe left
lung G2, pT2a, pN0
227 F 70
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Bronchioalveolar carcinoma lower
lobe left lung G2, pT2a, pN1
228 M 55
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Adenocarcinoma lower lobe left
lung G3, pT3, pN0
229 M 54
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Bronchioalveolar carcinoma lower
lobe right lung G1, pT2, pN0
230 M 74
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Adenocarcinoma lower lobe left
lung G3, pT2a, pN2
231 M 73
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Adenocarcinoma lower lobe left
lung G2, pT1a, pN0
232 F 54
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Anaplastic pulmonary carcinoma
G3, pT2a, pN0
233 F 51
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Pulmonary adenocarcinoma with
bronchioalveolar spread G3, pT2,
pN2
234 M 69
Neoplasm of uncertain
or unknown behavior of
trachea, bronchus and
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma lower lobe right
lung G2, pT3, pN0
235 M 53
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma upper lobe left
lung G3, pT2a, pN0
236 F 74
Neoplasm of uncertain
or unknown behavior of
trachea, bronchus and
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma lower lobe right
lung G2, pT2a, pN0
237 F 50 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
bronchus or lung
Multifocal pulmonary
adenocarcinoma right lung G2,
pT1a, pN0
238 M 58
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma lower lobe right
lung G2, pT2a, pN0
239 F 59
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Poorly differentiated necrotic
adenocarcinoma upper lobe left lung
pT1b, pN0
240 F 71
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma lower lobe right
lung G2, pT2a, pN0
241 F 54 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
bronchus or lung
Pulmonary adenocarcinoma G2,
pT2b, pN0
242 F 64
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Papillary pulmonary
adenocarcinoma
243 F 56
Neoplasm of uncertain
or unknown behavior of
trachea, bronchus and
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma upperlobe left lung
G2, pT4, pN1
244 M 69
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma upper lobe right
lung G2, pT1b, pN0
245 F 67
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma upper lobe right
lung pT1a, pN0
246 F 75 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
bronchus or lung
Desmoplastic pulmonary
adenocarcinoma G2, pT2a, pN0
247 F 53
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma upper lobe right
lung G3, pN1
248 F 65
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma upper lobe right
lung G2, pT2a, pN0
249 M 45
Malignant neoplasm of
middle lobe, bronchus
or lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma middle lobe right
lung G1, pT1a, pN0
250 F 77
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenocarcinoma upper lobe left
lung, pT2a, pN0
251 M 69
Malignant neoplasm of
upper lobe, bronchus or
lung
Neoplasm of upper lobe,
bronchus or lung with
uncertain biological
features
Neuroendocrine tumor lung G1,
pT1a, pN0
252 F 71
Malignant neoplasm of
middle lobe, bronchus
or lung
Malignant neoplasm of
middle lobe, bronchus
or lung
Neuroendocrine tumor lung G2
253 M 56
Malignant neoplasm of
lower lobe, bronchus or
lung
Neoplasm of lower lobe,
bronchus or lung with
uncertain biological
features
Neuroendocrine tumor lung G1,
pT1b, pN0
254 M 69
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Adenocarcinoma lower lobe left
lung G3, pT2 pN1
255 F 40 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
bronchus or lung
Neuroendocrine tumor lung pT1b,
pN0
256 F 66 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
bronchus or lung
Neuroendocrine tumor upper lobe
left lung G3, pT2a, pN0
257 F 27
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung Neuroendocrine tumor lung G1
258 F 62
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Bronchioalveolar carcinoma upper
lobe right lung pTis, pN0
259 F 62
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Bronchioalveolar carcinoma upper
lobe right lung G2, pT1b, pN0
260 F 54
Neoplasm of uncertain
or unknown behaviour
of Trachea, bronchus
and lung
Malignant neoplasm of
bronchus or lung
Bronchioalveolar carcinoma lower
lobe right lung G2, pT1a, pN0
261 M 68
Malignant neoplasm of
lower lobe, bronchus or
lung
Malignant neoplasm of
lower lobe, bronchus or
lung
Micropapillary adenocarcinoma
lower lobe right lung G2, pT2, pN0
262 M 69 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenosquamous carcinoma upper
lobe left lung, G2, pT3, pN2
263 M 67
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenosquamous carcinoma upper
lobe left lung G3, pT1b, pN0
264 F 61
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenosquamous carcinoma left lung
G2, pT2b, pN0
265 M 58
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Adenosquamous carcinoma upper
lobe right lung G2, pT1b, pN0
266 F 47
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenosquamous carcinoma (part
anaplastic) upper lobe lung G3, pT2,
pN1
267 M 71
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
bronchus or lung
Adenosquamous carcinoma upper
lobe right lung G3, pT2, pN0
268 F 64
Neoplasm of uncertain
or unknown behavior of
trachea, bronchus and
lung
Malignant neoplasm of
bronchus or lung
Adenosquamous carcinoma lower
lobe left lung G2, pT1a, pN1
269 M 63
Malignant neoplasm of
upper lobe, bronchus or
lung
Malignant neoplasm of
upper lobe, bronchus or
lung
Squamous cell carcinoma upper
lobe left lung G3, pT2, pN1
270 M 58 Malignant neoplasm of
bronchus or lung
Malignant neoplasm of
bronchus or lung
Squamous cell carcinoma middle
lobe right lung G3, pT2, pN0
271 F 39
Malignant neoplasm of
lower lobe, bronchus or
lung
Benign neoplasm of
bronchus and lung
Hamartochondroma lower lobe left
lung
272 M 43
Malignant neoplasm of
lower lobe, bronchus or
lung
Neoplasm of uncertain
or unknown behavior of
trachea, bronchus or
lung
Neuroendocrine tumor lung G1
(carcinoid)
273 F 48
Malignant neoplasm of
lower lobe, bronchus or
lung
Panlobular emphysema Pulmonary emphysema
274 F 45 Malignant neoplasm of
lungs or bronchus
Abscess of lung with
pneumonia Lung abscess
275 F 56 Malignant neoplasm of
lungs or bronchus Other disorders of lung
Pulmonary fibrotic change post
radiation middle and lower lobe
right lung
276 M 45
Malignant neoplasm of
lower lobe, bronchus or
lung
Other disorders of lung Pneumonia with fibrotic change
fibrosis
277 F 53 Malignant neoplasm of
lungs or bronchus Other disorders of lung Pneumonia with fibrotic change
278 F 59
Malignant neoplasm of
upper lobe, bronchus or
lung
Other disorders of lung No malignant neoplasm detected
279 F 52
Malignant neoplasm of
lower lobe, bronchus or
lung
Other disorders of lung No residual malignant neoplasm
detected
280 F 55 Malignant neoplasm of
retroperitoneum
Malignant neoplasm of
retroperitoneum
Retroperitoneal malignant fibrous
histiocytoma
281 F 42 Malignant neoplasm of
breast
Malignant neoplasm of
central portion of breast
Invasive ductal carcinoma breast
G3, pT4b, pN0
282 F 75 Malignant neoplasm of
breast
Malignant neoplasm of
central portion of breast
Invasive lobular carcinoma left
breast G2, pT2 pNX
283 F 53 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive ductal carcinoma breast,
G2, pT2, pN0
284 F 67 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Necrotic invasive ductal carcinoma
left breast G3, pT4b, pNX
285 M 39 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive ductal carcinoma breast
G1, pT2, pN0
286 F 60 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Recurrent invasive ductal carcinoma
breast with component of ductal
carcinoma in situ G3, pT1c, pN2a
287 F 72 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive ductal carcinoma left breast
G3, pT1c, pN0
288 F 83 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive ductal carcinoma right
breast G2, pT1a
289 F 89 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive ductal carcinoma right
breast G2, pT1c, pN1
290 F 56 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive ductal carcinoma left breast
G1, pT1a, pN1
291 F 72 Malignant neoplasm of
breast
Malignant neoplasm of
breast Invasive ductal carcinoma breast
292 F 41 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive ductal carcinoma breast
pT2, pN1
293 F 56 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive lobular carcinoma breast
G2, pT2, pN2a
294 F 83 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive lobular carcinoma breast
G1, pT2
295 F 85 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive ductal carcinoma breast
G3, pT2, pN0
296 F 52 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive lobular carcinoma breast
G2, Pt2, pN2
297 F 79 Malignant neoplasm of
breast
Malignant neoplasm of
breast
Invasive lobular carcinoma, pT1c,
pN0
298 F 59 Malignant neoplasm of
breast
Benign neoplasm of
breast Fibroadenoma breast
299 F 19 Benign neoplasm of
breast
Benign neoplasm of
breast Fibroadenoma breast
300 F 78 Malignant neoplasm of
ascending colon
Malignant neoplasm of
ovary
Carcinosarcoma, ovaries, G3, pT3,
pN2a
301 M 59 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of lymph node
Metastatic adenocarcinoma in
lymph node of hepatic ligament
302 F 61
Neoplasm of uncertain
or unknown behavior of
trachea, bronchus and
lung
Secondary malignant
neoplasm of lung
Pulmonary metastasis from breast
cancer primary tumor (invasive duct
adenocarcinoma)
303 M 50
Neoplasm of uncertain
or unknown behavior of
trachea, bronchus and
lung
Secondary malignant
neoplasm of lung
Pulmonary metastasis from primary
colonic adenocarcinoma.
304 F 58
Neoplasm of uncertain
or unknown behavior of
small intestine
Secondary malignant
neoplasm of small
intestine
Peritoneal carcinomatosis
305 M 45 Malignant neoplasm of
sigmoid colon
Secondary malignant
neoplasm of
retroperitoneum and
peritoneum
Peritoneal carcinomatosis
306 M 68 Malignant neoplasm of
peritoneum
Secondary malignant
neoplasm of
retroperitoneum and
peritoneum
Peritoneal adenocarcinoma
metastases
307 M 62
Malignant neoplasm of
connective and soft
tissue of trunk
Secondary malignant
neoplasm of
retroperitoneum and
peritoneum
Peritoneal adenocarcinoma
metastases
308 M 73 Malignant neoplasm of
sigmoid colon
Secondary malignant
neoplasm of
retroperitoneum and
peritoneum
Omental adenocarcinoma
metastases
309 M 58
Secondary malignant
neoplasm of
retroperitoneum and
peritoneum
Secondary malignant
neoplasm of
retroperitoneum and
peritoneum
Peritoneal carcinomatosis from
primary pancreatic adenocarcinoma.
310 F 53 Malignant neoplasm of
rectum
Secondary malignant
neoplasm of
retroperitoneum and
Omental metastases from primary
colonic adenocarcinoma.
peritoneum
311 F 75 Malignant neoplasm of
ascending colon
Secondary malignant
neoplasm of
retroperitoneum and
peritoneum
Omental metastases from primary
colonic adenocarcinoma.
312 M 73 Malignant neoplasm of
liver
Malignant neoplasm of
liver Hepatic cholangiocarcinoma
313 M 63 Secondary malignant
neoplasm of liver
Malignant neoplasm of
liver Hepatic cholangiocarcinoma
314 M 59 Malignant neoplasm of
liver
Malignant neoplasm of
liver Hepatocellular carcinoma
315 F 56 Secondary malignant
neoplasm of liver
Malignant neoplasm of
liver
Hepatocellular carcinoma G2, pT1,
pNx
316 M 68 Malignant neoplasm of
liver
Malignant neoplasm of
liver Hepatocellular carcinoma
317 M 78 Secondary malignant
neoplasm of liver
Malignant neoplasm of
liver Hepatocellular carcinoma, G2
318 M 58 Malignant neoplasm of
liver
Malignant neoplasm of
liver Hepatocellular carcinoma, G1
319 F 62 Malignant neoplasm of
liver
Malignant neoplasm of
liver Hepatocellular carcinoma
320 M 73 Malignant neoplasm of
liver
Malignant neoplasm of
liver Hepatocellular carcinoma, G1
321 M 68 Malignant neoplasm of
liver
Malignant neoplasm of
liver Hepatic cholangiocarcinoma
322 M 79 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic carcinoma
323 M 55 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic carcinoma
324 F 70 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic carcinoma
325 M 61 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastases from primary
adenocarcinoma
326 F 74 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
endocrine tumor
327 F 75 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
328 F 61 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
329 F 73 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
330 M 57 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastases from primary
colonic adenocarcinoma
331 M 59 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
adenocarcinoma
332 F 63 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
333 M 64 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
334 M 57 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
335 F 69 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
336 M 69 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
337 F 54 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
338 M 68 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
339 M 52 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
colonic adenocarcinoma
340 M 82 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
carcinoma of stomach
341 M 62 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
rectal adenocarcinoma
342 M 59 Secondary malignant
neoplasm of liver
Secondary malignant
neoplasm of liver
Hepatic metastasis from primary
rectal adenocarcinoma
343 F 67 Benign neoplasm of
liver
Other specified diseases
of liver Intrahepatic cholangiodysplasia
344 F 22 Focal nodular
hyperplasia of liver
Focal nodular
hyperplasia of liver Focal nodular hyperplasia of liver
345 F 55 Benign neoplasm of
liver Haemangioma Hepatic cavernous haemangioma
346 F 70 Malignant neoplasm of
gallbladder Cholangitis Chronic cholangitis
347 M 56 Benign neoplasm of
thyroid gland
Secondary malignant
neoplasm of other
specified sites
Thyroid metastasis from primary
renal clear cell carcinoma
348 F 73
Malignant neoplasm of
connective and soft
tissue
Secondary malignant
neoplasm of other
specified sites
Metastasis from primary
endometrial carcinoma
349 M 68
Malignant neoplasm of
connective and soft
tissue of trunk
Secondary malignant
neoplasm of other
specified sites
Peritoneal metastasis from primary
colonic adenocarcinoma
350 M 59 Malignant neoplasm of
thyroid gland
Secondary malignant
neoplasm of other
specified sites
Thyroid metastasis from primary
pulmonary adenocarcinoma
351 F 80
Secondary malignant
neoplasm of lymph
nodes of head and neck
Secondary malignant
neoplasm of other
specified sites
Lymph node metastasis from
primary papillary thyroid carcinoma
352 F 32 Diseases of
mediastinum Hodgkin’s lymphoma Lymph node Hodgkin’s lymphoma
353 F 61 Benign neoplasm of
cerebral meninges
Benign neoplasm of
cerebral meninges Meningioma
354 M 38 Benign neoplasm of
cranial nerves
Benign neoplasm of
cranial nerves
Neurilemmoma (benign
schwannoma)
355 M 44 Malignant neoplasm of
brain frontal lobe
Malignant neoplasm of
brain Astrocytoma WHO grade II
356 M 42 Malignant neoplasm of
brain
Malignant neoplasm of
brain
Anaplastic astrocytoma WHO grade
III
357 M 64
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary
pulmonary carcinoma
358 M 61
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary
pulmonary carcinoma
359 M 63 Malignant neoplasm of
brain
Malignant neoplasm of
brain Glioblastoma multiforme
360 M 72 Malignant neoplasm of
brain temporal lobe
Malignant neoplasm of
brain temporal lobe Glioblastoma multiforme
361 F 57 Malignant neoplasm of
brain
Malignant neoplasm of
brain parietal lobe Gemistocystic astrocytoma
362 F 61 Malignant neoplasm of
brain frontal lobe
Malignant neoplasm of
brain frontal lobe
Recurrent necrotic glioblastoma
multiforme
363 F 65
Benign neoplasm of
cerebral meninges:
meningioma
Benign neoplasm of
cerebral meninges:
meningioma
Fibrous meningioma
364 F 61 Benign neoplasm of
cranial nerves
Benign neoplasm of
cranial nerves
Neurilemmoma (benign
schwannoma)
365 F 54 Malignant neoplasm of
brain frontal lobe
Malignant neoplasm of
brain frontal lobe Glioblastoma multiforme
366 M 66
Neoplasm of uncertain
or unknown behavior of
brain
Neoplasm of uncertain
or unknown behavior of
meninges
Meningioma WHO grade II
367 M 59
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from unknown
origin
368 M 58 Benign neoplasm of
cerebral meninges
Malignant neoplasm of
brain occipital lobe
Astrocytoma WHO grade IV
(glioblastoma multiforme)
369 F 19 Benign neoplasm of
cranial nerves
Benign neoplasm of
cranial nerves
Neurilemmoma (benign
schwannoma)
370 F 24
Neoplasm of uncertain
or unknown behavior of
brain
Malignant neoplasm of
brain frontal lobe
Gemistocystic astrocytoma WHO
grade II
371 M 40
Benign neoplasm of
cerebral meninges:
meningioma
Malignant neoplasm of
meninges Meningioma WHO grade III
372 F 18 Malignant neoplasm of
brain frontal lobe
Malignant neoplasm of
brain frontal lobe Oligoastrocytoma WHO grade III
373 M 73
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary
colonic carcinoma
374 M 57 Benign neoplasm of
cerebral meninges
Neoplasm of uncertain
or unknown behavior of
cerebral meninges
Transitional meningioma
375 F 41
Secondary malignant
neoplasm of brain and
cerebral meninges
Other disorder of brain
Necrotic tissue from radiation
therapy, no malignant cells
identified
376 M 66
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary lung
adenocarcinoma
377 M 66
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary
pulmonary large cell anaplastic
carcinoma
378 F 39
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary
ductal carcinoma of breast
379 F 62
Neoplasm of uncertain
or unknown behavior of
brain
Other disorder of brain Chronic cerebral abscess
380 F 59
Neoplasm of uncertain
or unknown behavior of
brain
Malignant neoplasm of
cerebrum Glioblastoma multiforme
381 M 16 Malignant neoplasm of
brain occipital lobe
Neoplasm of uncertain
or unknown behavior of
central nervous system
Ganglioglioma
382 M 60 Malignant neoplasm of
brain occipital lobe
Malignant neoplasm of
brain occipital lobe
Astrocytoma WHO grade IV
(glioblastoma multiforme)
383 M 68 Malignant neoplasm of
cerebellum
Malignant neoplasm of
cerebellum
Malignant glioma WHO grade IV
(glioblastoma multiforme)
384 M 82
Benign neoplasm of
cerebral meninges,
parasagittal meningioma
Benign neoplasm of
cerebral meninges,
parasagittal meningioma
Atypical meningioma WHO grade
II.
385 M 46 Malignant neoplasm of
brain frontal lobe
Malignant neoplasm of
brain frontal lobe Glioblastoma multiforme
386 M 61
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary
pulmonary carcinoma
387 F 67
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary
pulmonary carcinoma
388 F 62 Malignant neoplasm of
brain frontal lobe
Malignant neoplasm of
brain frontal lobe
Anaplastic astrocytoma WHO grade
III
389 F 67
Secondary malignant
neoplasm of brain and
cerebral meninges
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from unknown
primary tumor
390 F 66
Benign neoplasm of
cerebral meninges:
meningioma
Benign neoplasm of
cerebral meninges:
meningioma
Meningioma WHO grade I
391 M 65
Benign neoplasm of
cerebral meninges:
meningioma
Benign neoplasm of
cerebral meninges:
meningioma
Atypical meningioma WHO grade
II
392 F 48
Neoplasm of uncertain
or unknown behavior of
brain
Secondary malignant
neoplasm of brain and
cerebral meninges
Brain metastasis from primary
pulmonary or thyroid origin
393 F 60 Benign neoplasm of
cerebral meninges
Benign neoplasm of
cerebral meninges
Atypical meningioma WHO grade
II