subjectindex 1962...

ABS -AID

(1)86828682868286828682

rates 8682

868286828682

867386968671871586718672

86718715

869687158715

868586858685

(3)

87068706

87158715

86968696867286718715867186718671

8715869686968671

8715

8715

86718671

8671

86718715

869687158671

867386728673

bronchomotor responses

dichloroi soproterenol

8675

8675

8675

8699

8699

8675(10)

1962SUBJECT INDEX

3955-1

ABSORPTION

absorption kinetics

body fluid exposure

diffusion layer pH

dissociation constants

drug solubility

experimentally observed

implant surface area

physicochemical properties

serum solubility

subcutaneous pellet

implantation

theoretically calculated

rates

ACETAZOLAMIDE (2)

chlorphthalidolone comparison 8720

electrolyte excretion 8720

8720intact animals

ACETYLCHOLINE

aortic chains

atropine

8671brain betaine estersbrain choline esters

chronic denervation

cocaine modification

concentration effect

contraction response

dose effect

dose-response curves

8715

epinephrine pretreatment

ether narcosis

frog rectus preparation

intra-arterial injection

8672isolated rabbit aorta

methachol me

muscarinic action

nicotinic action

nictitating membrane

norepinephrine modification

norepinephrine pretreatment

pentobarbital narcosis

phase responses

phenoxybenzamine modi fication

postganglionic action

potentials

postganglionic responses

potentiating action

preganglionic nerve

stimulationrat brain extracts

reserpine pretreatment

serotonin pretreatment

spinal cats

sympathetic ganglia

8673TM-lO pretreatment

tone effectstttotal1t acetylcholine

8682 activity

vasoconstrictor activity

8682 vasodilator activity

ACETYLSTROPHANTHIDIN (4)

frequency-force relationship

isolated heart muscle

post-stimulation potentiation

ADRENAL GLANDS (5)epinephrine concentration 8706

morphine-tolerant animals 8706

nalorphine pretreatment 8706

nalorphine-induced withdrawal 8706norepinephrine concentration 8706

1 -phenyl -2-hydrazinopropane

(11B 516)rectal temperature

ADRENALECTOMY (6)2,2’-bipyridine hyperglycemia 8711

blocking effect 8711

fasted rats 8711

ADRENERGIC RECEPTOR MECHANISM(7)bronchiolar smooth muscle 8692

86928692

pulmonary vasomotor responses 8692

sympathomimet ic

bronchodilators 8692

ADRENOCORTICAL STEROIDS (8)

al dosterone

cardiotonic action


ALCOHOL INTOXICATION,

EXPERIMENTAL (9)

albino mice

chioro form- induced

liver damage

ALDOSTERONE

cardiotonic action

direct myocardial effect 8675

AID-BAR VOL. 135

isolated heart muscle 8675 AORTA, ISOLATED (21)

pH values 8675 acetyicholine constrictor

Gamma-ANINOBUTYRIC ACID (11) effect 8715

brain content 8707 acetylcholine dilator effect 8715

morphine tolerant animals 8707 rabbit aortic chains 8715

nalorphine-induced abstinence 8707 ARTERIES, PULMONARY (22)

AMPHETAMINE (12) anesthetized dogs 8687

motor activity response 8669 bretylium pretreatment 8687

tetrahydrocannabinols 8669 cardiac response 8687

d-AMPHETAMINE (13) dichloroi soproterenol

aggregated animals 8698 pretreatment 8687

albino mice 8698 DMPP response 8687drug antagonists 8698 epinephrine pretreatment 8687

excitatory effects 8698 heart rate 8687

isolated animals 8698 heart-lung preparation 8687

lethal effects 8698 left ventricular force 8687

strain difference 8698 partial occlusion 8687

variable responses 8698 right ventricular pressure 8687

ANALGESICS (14) sympathetic cardiac reflexes 8687

cellular adaptation 8678 systemic blood pressure 8687

morphinized rats 8678 systemic flow 8687

narcotic agents 8678 ATROPINE (23)

ANESTHETICS, GENERAL (15) ACh responses 8672

brain esters 8696 blocking action 8714

ether narcosis 8696 DFP-induced discharge 8672

pentobarbital narcosis 8696 ganglionic stimulants 8714

“total” acetylcholine postganglionic potentials 8672

activity 8696 sympathetic ganglia 8672

ANTACIDS (16) AUTONOMIC GANGLIA (24)

polymyxin B-induced anesthetized cat 8714

gastric hemorrhage 8702 blocking agents 8714

protective activity 8702 DMPP stimulant action 8714

ANTICHOLINERGIC AGENTS (17)

polymyxin B-induced

gastric hemorrhage

protective activity

ANTIDIURESIS (18)

benzothiadiazines

diabetes insipidus

ANTIHISTAMINES (19)

polymyxin B-induced

gastric hemorrhage

protective effect

ANTIHYPERTENSIVE AGENTS (20)

experimental atheromatosis 8718

hypertensive rats 8718 BARBITAL (26)

hypocholesterolemic activity 8718 acute toxicity 8694

mecamylamine 8718 blood levels 8694

normotensive rats 8718 diffusion rate 8694

reserpine 8718 distribution volume 8694

5-NT stimulant action 8714

inferior mesenteric ganglion 8714

8702 AUTONOMIC NERVOUS SYSTEM (25)

8702 acetylcholine effect 8691

blood pressure 8691

8720 heart phosphorylase a

8720 activity 8691

isolated heart 8691

parasympathetic stimulation 8691

8702 sympathetic ganglionic

8702 stimulation 8691

SUBJECT � INDEX

5-2

8694

8694

8694

8694

8694

8694

BAR-BLO

(34)

(28)

8720

8720

8720

8720

8720

8720

8720

8720

8720

cyclopenthiazide

diabetes insipidus


hydrochlorothiazide

trichlormethiazide

BENZOYL-l-ARGININE ETHYL ESTER

(BABE) (29)

heparinized plasma hydrolysis 8701

human subjects 8701

(30)

(31)

( 32)

8711

86748674867486748674.86748674

8674

8703870187038701870187018703

867786868713

86868668

86898677871886778674

86898697

86978676

87138674866886868697

8716

8674

86698669

8718

8718

866886768674

8664

8664

8664

8714

8714

86678667

8665

8665

(33)

1962SUBJECT INDEX

5-3

environmental temperature

male rats

mortality rate

oil-water distribution

plasma protein binding

rectal temperature

BARBITURATES

albino rats

brain 5-NT content

BENZOTHIADIAZINES

action duration

antidiuretic potency

benzydroflumethiazi de

chlorothiazide

oxalated plasma hydrolysis

serum hydrolysis

BENZYLHYDRAZINE

MAO inhibitor activity

NQS effect

preincubation period

BENZYLOXYGRANINE

blocking action

ganglionic stimulants

BIOASSAY

brain 5-NT content

CNS depressants

heart

indoleacetic acid formation

monoamine oxidase activity

in vitro

sympathetic ganglia

tissue homogenates

tryptamine conversion

venus mercenaria heart

2 , 2 ‘ -BIPYRIDINE

blood glucose responses

chelating agent

dose-response relationships

fasted rats

fed rats

hyperglycemic activity

time-response relationships

toxicity

BLADDER

atropine

carbachol


hexamethonium

(27) intravesical pressure

8667 pelvic nerve preparation

8667 tetraethylammonium

tremorine effect

BLOOD ‘ (35)

anesthetized rabbits

arginine esterase activity

CSF-blood transport

esterolytic activity

heparin effect

human subjects

lipid-insoluble substances

BLOOD PRESSURE (36)

acetylcholine

acetylcholine response

anesthetized cats

anesthetized chickens

8701 anesthetized dogs

8701 8676 8689 8697 8716


anesthetized rats

antihypertensive agents

atropine

atropine effect

8676

basilar artery ligation

carotid body chemoreceptors

carotid sinus baroreceptorscarotid sinus denervation

C6-C1-4 tissue concentration

C-O pressor reflex

C-O pressor response

8665 compound 48/80

8665 cyclopropane effects

8665 cyclopropane responses

8665 depressor activity

8667 dichloroisoproterenol

pretreatment

8711 epinephrine pressor response

8711 8677

8711 experimental atheromatosis

8711 experimental hypertension

8711 guanethidine effect

8711 hexamethonium blockade

8711 hexamethonium effect

VOL. 135

866987138686868986898677

8689

8704870586968678

8678

8704

869686678700

8693

8704

8705866686968705

8713870587058667

86668700870087008706

866886868676

87168676868986768686871886898669868686748686

86688674

( 38)

(39)

870686668696870686668704

86668706

8704

8696

8704

SUBJECT INDEX

S-4

BLO-BRA

hexamethonium pretreatment

hexamethonium-C 14

histamine response

hydroquinone responses

intracarotid injection

intravenous injections

intravertebral injection

isoproterenol depressor

response

lobeline

male rats

midbrain section

nicotine

nicotine-like actions

norepinephrine pressor

response

8677norepinephrine response

parabromdylamine effect

phenoxybenzamine pretreatment

8677pressor effects

pressor responses

resorcinol responses

ret ama

serotonin response

serum cholesterol levels

spinal cord transection

spinal section

tissue histamine depletion

tremorine

tryptamine response

tyramine response

vagotomy

8676vagus nerve stimulation

BLOOD SUGAR (37)

2,2’-bipyridine hyperglycemia 8711

fasted rats 8711

BODY TEMPERATUREmorphine-tolerant dogs

nalorphine administration

BRAIN

albino mice

albino rats

gamma-aminobutyric acid

content

amygdala

anesthetized cats

anesthetized dogs

area postrema

ataxia

behavioral effects

betaine ester concentration

cellular adaptation

cerebral cortical slices

8700chloral hydrate concentration

choline ester concentration

8669 CNS depressants

8677 cross-cellular adaptation

8718 H3-DCI localization

8669 depression stages

8677 electrical activity

8676 epinephrine uptake

ether narcosis

8669 evoked seizure activity

hexamethonium-C 14

concentrat ion

hippocampus

gamma-hydroxybutyrate5-hydroxytryptamine content

8707intercolumnar tubercle

KC1-stimulated slicesmeperidine

methadone

morphine tolerant animals

8707morphinized rats 8678

8700

nalorphine reversal 8678

nalorphine-induced abstinence 8706

8707norepinephrine concentration 8706

oxygen consumption 8700

8674 pentobarbital narcosis 8696

pharmacological responses 8713


(JB-5l6)pineal body

8706 rat brain extracts

8706 rectal temperature

reserpine effect

8704 righting reflex

8667 special areas

species differences

8707 tissue homogenates

8705 “total” acetylcholine

8666 activity

8693 trichloroethanol

8666 concentration

BRE -CEN

8683

8683

8683

8683

8683

8683

8683

8697

86978697

8697

869786978697

87068716

870687178716

8717870887178717

87088706

8708

8690

8690

871787168717

8708

8678

870087008700870086788700870086788700

871187058667866786678666

866787058667

8685

86858685

8685

8716

8691

869187168691

8691

8691

8689

8689

8689

8697

8697

8697

869786978697

8697

(46)

1962SUBJECT INDEX

5-5

BRETYLIUN TOSYLATE (40)

action mechanism 8687

DMPP responses 8687

heart-lung preparation 8687

pulmonary arterial occlusion 8687

BROM-LYSERGIC ACID DIETHYLAMIDEblocking action (41) 8714

ganglionic stimulants 8714

BUTYNAMINE (42)

butynamine-Cl4 administration

N-demethylation � vitro

des-N-methyl butynamine

formation

enzyme activity

human subjects

metabolism in vivo

radioactive metabolites

CARBONIC ANHYDRASE INHIBITION

brain 5-HT content (43) 8667

methazolamide 8667

CARDIOACTIVE GLYCOSIDES (44)



positive inotropic effect


CARDIOVASCULAR SYSTEM (45)anesthetized dogs

autonomic nervous system

blood pressure

cyclopropane responses

heart contractile force

heart phosphorylase a

activity

isolated heart

resorcinol isomers

spinal cord action site

sympathetic stimulation

CAROTID BODY

anesthetized dogs

chemoreceptor sensitivity

cyclopropane inhalation

CAROTID SINUS (47)

acute hemorrhage

anesthetized dogs

arterial blood pressure

baroreceptor sensitivity

constant pressure distensions 8697

cyclopropane. inhalation 8697

electrocardiogram 8697

intraluminal pressure

nerve action potentials

peak frequency discharge

pressure-frequency discharge

curves

pulsatile stimulation

receptor pressure threshold

vagosympathetic nerve block

CATECHOLAMINES (48)adrenal gland content

anesthesia levels

brain content

chronotropic effects


endogenous release

heart content

heart’ muscle

inotropic effects

intestine content

morphine tolerance

morphine-tolerant animals

nictitating membrane content

norepinephrine sensitization

N-oxide analogs

plasma concentration

pyridine derivatives

spleen content

CELLS, CEREBRAL CORTEX (49)


8700

cross-cellular adaptation

KC1-stimulated slices

meperidine

methadone

morphine adaptation

morphinized rats

nalorphine effect

nalorphine reversing effect

oxygen consumption

CENTRAL NERVOUS SYSTEM (50)adrenal medullary hormones

albino mice

albino rats

analgesics

anesthetics

anesthetized cats

anticonvul sant s

behavioral studies

bioassay

2 , 2 ‘ -bipyridine-induced

hyperglycemia 8711

blood-brain barrier

brain

brain 5-HT levels

carbonic anhydrase inhibitors

VOL. 135

chioro form-ethanol

pretreatment

hepatotoxic susceptibility

liver content

liver damage

liver lipids

�-CHLOROMERCURIBENZOATE

acid-base balance

chlorothiazide activity

electrolyte excretion

inhibitor activity

meralluride comparison

mercurial diuresis

renal blood flow

renal hemodynamic changes

renal perfusion pressure

pentobarbital sleeping time

reflex activity

reflexes


sedatives

spontaneous motor activity

saline diuresis

urine flow

water excretion

2-CHLOROMERCURIPNENYLinhibitor activity

mercurial diuresis

CHLOROTHIAZIDE

antidiuretic effect

diabetes insipidus

probenecid influence

CHLORPHENIRAMINE

polymyxin B-induced

8703 gastric hemorrhage

8703 protective effect

8703 C}LLORPHTHALIDOLONE

8703 action duration

8703 antidiuretic potency

8703 diabetes insipidus

8703 electrolyte excretion

8703 CHLORPROMAZINE

polymyxin B-induced

CSF-blood transport

intracisternal injection

intraventricular injection


radioactivity measurements

( 52)

( 53)

( 58)

( 59)

(60)

(61)

(62)

8711 gastric hemorrhage

8711 protective effect

8711 CHOLESTEROL

antihypertensive agents

8704

8667

8704

8704

8704

trichloroethanol comparison 8704

CHLOROFORM (54)

acute ethanol intoxication

chloroform pretreatment

hypertensive rats

serum levels

CHOLINESTERASES

bovine erythrocytes

intestinal mucosa

8699 neostigmine comparison 8674

8699 tremorine inhibitor activity 8674

CEN-CHOSUBJECT INDEX

S -6

catatonia

catecholamine content

cerebellum

depressant drugs

depressant effects

EEG

epinephrine infusion

epinephrine uptake

guanethidine inhibitor

8666

8666

8667

8667

8669

8666

86668667

8705

8705

8666

8666

effect 8668

8705

8705

8667

8666

8667

8705

8705

8669

86668667

8705

8669

8666

8668

hexobarbital sleeping time

gamma-hydroxybutyrate

hypnotics

hypothalamus

MAO inhibitors

tetrahydrocannabinol s

tissue concentration

vasomotor activity

CEREBROSPINAL FLUID


C14-labeled saccharides

urinary excretion

CHELATING AGENTS

2 , 2 ‘ -bipyridine

fasted rats

hyperglycemic response

CHLORAL HYDRATE

albino mice

brain 5-HT content

brain tissue concentration

hypnotic activity

metabolism

( 51)

atherogenic diet

fec#{225}l excretion

86998699

8699

8699

8699

(�-CMB)

(55)8680

8680

8681

8680

8681

8680

8681

8681

868186808681

8681

SULFONATE(56)8680

8680( 57)

8720

8720

8720

8702

8702

8720

8720

8720

8720

87028702

8718

87188718

87188718

8674

8674

(64)

8685

8685

post-stimulation potentiation 8685

rate-dependent mechanism 8685

CORONARY BLOOD FLOW (65)

isolated perfused rat heart 8677

posterior pituitary hormone 8677

COTININE (66)

chloroform- soluble

87208720

872087208720

8714

8714

8702

8702

8692

8692

(72)

(73)

( 74)

(67)

(68)

(69)

8683

8683

8683

86728672

86698669

86878714

8687

(79)

1962SUBJECT INDEX

COC-DIN

5-7

COCAINEacetylcholine response

blocking action


ganglion stimulants

intravenous administration



CONTRACTION , HEARTisolated heart muscle

ouabain effect

metabolite s

human subject

metabol sm

oral administration

urinary excretion

CYCLOPROPANEaction mechanism

anesthesia levels

anesthetized dogs

8716

carotid body chemoreceptors

carotid sinus baroreceptors

circulatory responses

corneal reflex

lid reflex

sympathoadrenal responses

CYPROHEPTADINE

polymyxin B-induced

gastric hemorrhage

protective effect

N-DEMETHYLATIONbutynamine

rat liver microsomes

substrate concentration

DEXTRAN

CSF-blood transport

nephrectomized animals

DIABETES INS IPIDUS,

EXPERIMENTALac e tazol ami de

antidiuretic effect

(63) benzothiadiazines

8671 hydrochlorothiazide

8714 hypothalamic electrolytic

8671 lesions

8714 male rats8671 water intake

8671 DIBENZYLINE

8671 blocking action


polymyxin B-induced

gastric hemorrhage

protective effect

DICHLOROISOPROTERENOL

reversing action

sympathomimetic

bronchodi lators

� -DICHLOROISOPROTERENOLalbino mice 8693

8709 anesthetized dogs 8693

8709 lipoid solubility 8693

8709 metabolism 8693

8709 physiological disposition 8693

8709 plasma concentration 8693

tissue binding 8693

8697 tissue distribution 8693

8716 DIGITALIS GLYCOSIDES (75)

8697 frequency-force relationship 8685

isolated heart muscle 8685

8697 post-stimulation potentiation 8685

8697 DIHYDROERGOTAMINE (76)

8716 adrenergic blockade 8711

8716 2 , 2’ -bipyridine hyperglycemia 8711

8716 fasted rats 8711

8716 DIISOPROPYL FLUOROPHOSPHATE (77)

acetylcholine effect 8672

ganglionic blocking agents 8672

8702 intra-arterial injections 8672

8702 postganglionic action

potentials 8672

postganglionic discharge 8672

repetitive preganglionic

S timulat ion

sympathetic ganglia

DIMETHYL-HEPTYL-PYRAN (DMHP) (78)

(70) chemical structure

8703 pharmacological effects

8703 1 , l-DIMETHYL-4-PHENYL-PIPERAZINIUN (DMPP)

(71) action site

8720 anesthetized cat

8720 atropine pretreatment

neutral compounds

organic weak acids

organic weak bases

physicochemical properties

DIM-ENZ

biphasic response

bretylium pretreatment

ganglionic blocking agents

ganglionic stimulation

8714

heart rate

heart-lung preparation

inferior mesenteric ganglion

left ventricular force.

right ventricular pressure

systemic blood flow

systemic blood pressure

DIPHENYLHYDANTQIN (80)brain 5-NT content

1 ,4-DIPYRROLIDINO-2-BUTYNE

(TRE1&�RINE) (81)action sites

autonomic effects

DIURESIS, MERCURIAL (82)ammonium chloride

pretreatment

anesthetized dogs

chloride excretion

chlormerodrin response

�-chl oromercuriphenyl

sulfonate

�-CMB inhibitor activity

dibenaminedimercaprol reversal

dose-response relationship

glomerular filtration

mercaptomerin response

mersalyl response

nondiuretic mercurial effects

oxophenar sine

SY-28urine flow

DIURESIS, WATER (83)

human subjects

8667

ELECTROCARDIOGRAManesthesia levels

867.4 anesthetized rats

8674 cyclopropane inhalation

posterior pituitary

ELECTROENCEPHALOGRAM

arousal response

ascending reticular system

cortical areas

evoked seizures

ganima-hydroxybutyrate

spindling

thalamo-cortical recruitment

ELECTROLYTES (88)

acetazolamide

chlorphthal idolone

hydrochlorothiazide

urinary excretion

ENZYMES (89)albino mice


8677

lobeline inhibitor activity 8677

urine volume 8677

DIURETICS , MERCURIAL (84)


blood arginine esterase

activity

butynamine N-demethylation

chl oroforni- induced

heart phosphorylase a

activity

heparin effect

human subjects

isolated heart

liver fluke homogenates

liver succinic dehydrogenase

SUBJECT INDEX

activity

perfused kidney

water excretion

DRUGS, ADMINISTRATIONabsorption rate

barbiturates

cholesterol

codeine

medrol

(85)

8687

86878714

8687

8687

86878714

86878687

86878687

8680868086808680

86808680

86808680868086808680

86808680

868086808680

86818681

8681

868286828682868286S2

morphine

subcutaneous pellet

implantation

sulfonamides

tetracycline

theobromin#{235}

theophylline

tolbutamide

urea

liver damage

demethylase activity

ethanol pretreatment

glycolytic systems

VOL. 135

(86)

86828682868286828682

8682

868286828682868286828682

871686778716

hormone 8677

(87)8705870587058705870587058705

8720872087208720

86998691

87018683

869986838&99

8679

86918701870186918679

8699

(90)

ENZ-GAN

8665 “total” acetylcholine

8679 activity 8696

8683 ETHER, DIETHYL (95)

8665 brain 5-NT content 8667

8679 inhalation anesthesia 8667

8665 ETHYL MERCURY CHLORIDE (96)

mercurial diuresis 8680

8670 nondiur#{233}tic mercurial 8680

86 70 N-ETHYL-NORTROPINE -BENZHYDRYL-

8670 ETHER (97)

8670 antiarrhythmia action 8684

isolated cat heart 8684

8715 isolated heart muscle 8684

pentylenetetrazol 8684

(91)

8692

8692

8670

8670

8715

8670

8692

8702

8702

8692

8670

8692

(98)

(99)

(92) 8714

8666

866&

8666

benzyloxygramine

brom-lysergic acid

diethylamide

8666

8666

8666

8666

8679

8679

8679

8672

86738714

8673

8714

8714

86738714

8672

8714

86738714

86738672

8673

87138714

8714

8672

8714

8714

8713

8672

8699

8699

8699

(93)

(94)

1962

SUBJECT INDEX

5-9

MAO activity

phosphofructokinase activity

rat liver microsomes

sensitivity assay

serotonin effect

tissue homogenates

EPHEDRINE

action mechanism

inhibitor activity

isolated rabbit ileum


EPINEPHRINE



DCI pretreatment


inhibitor activity

isolated aorta


perfusion pressure

polymyxin B-induced

gastric hemorrhage

protective effect

pulmonary arterial pressure


ventilation overflow

H3-EPINEPHRINE

blood-brain barrier

CNS uptake

intravenous infusion

isolated brain tissue

labeled amine incubation

in vitro

pituitary slices


tissue slices

ETHANOL

acute intoxication

albino mice

blood content

chloroform-induced

liver damage

hepatotoxic susceptibility

liver content

liver lipids

oral administration

physiological response

ETHERanesthetized rats

brain esters

FASCIOLA HEPATICA

glycolysi sliver fluke homogenates

serotonin effect

GANGLIONIC BLOCKING AGENTS

acetylcholine responses

gamma-aminobutyric acid

anesthetized cat

atropine

8666 cell group responses

cocaine

DFP-induced postganglionic

discharge

dibenzyline

differential blockade

DMPP-induced stimulation

epinephrine

ganglionic transmission

hexame t honi um

8714

8699 hexamethonium-Cl4

8699 5-HT-induced stimulation

8699 inferior mesenteric ganglion

8699 intra-arterial injections

8699 lysergic acid diethylamide

8699 morphine

pharmacological activity


8696 potentials

VOL. 135

(105)

(100)

8672

8672

8672

86738673

8713

8673

8673

8714

8714

8673

8687

8687

8714

8714

8673

8673

8673

di gitoxin

N,N-dimethylformamide muscle

extracts

drug effects

epinephrine

epinephrine /norepinephrine

ratio

(102)

morphine-induced convulsions

8712

8689

8717

8665

8689

8712

8717

8708

8717

8689

8712

8712

8712

8712

8708

8717

8717

8689

86658712

8708

8708

87128712

8689

8712

87178717

8712

8712

8717

8712

8689

8717

8689

8665

8712

8684

8684

8684

8684

8684

86688668

8668

8668

8688

8688

8668

8668

8688

8688

8668

8688

8688

8668

8668

(106)

SUBJECT INDEX

S -10

GAN-HEA

preganglionic nerve

stimulation

presynaptic nerve terminals

sympathetic ganglia

8673

synaptic depressants

tetraethylammonium

tissue distribution

.�- tubocurarine

GANGLIONIC STIMULANTSacetyicholine effect

anesthetized cat

blocking agents

cell group responses

DNPP activity

8714

heart - lung preparation

5-hydroxytryptamine activity

inferior mesenteric ganglion

nicotine

sympathetic ganglia

tetramethylammonium

GASTRIC HEMORRHAGE

gastric ulcer formationhemostasi s

mortality

polymyxin B induced

protective agents

GLYCOLYSISliver fluke homogenates

serotonin-treated flukes

GUANETHIDINE

anesthetized dogs

blood pressure

blood-brain barrier

bradycardia

cardiac norepinephrine

content

cardioaccelerator effect

central administration

central inhibition

heart rate

intact rat heart

intravenous admini stration

isolated mammalian heart

reserpine comparison

vasodepressor effect

vasomotor activity

HARMALINE

brain 5-HT content

HEART“aging” effect

anesthetized intact dogs

atropine pretreatment

bioassay

blood pressure

cardiac glycosides

cardiac output


8717

competence index

contractile force

8712


inotropic effects

(101) intravertebral injection

8702 MAO activity8702 methacholine

8702

8702

8702

morphine-tolerant animals

nerve stimulation

nucleic acid fragments

8679 open-chest dogs

8679 8712

(103) ouabain

N-oxide analogs

pentobarbital failure

perfusion experiments

potassium


rate effect

8717

resorcinol responses

right atrial pressure

spinal cord transection

tissue homogenates

veratri dine

HEART ARRHYTHMIA

A-V block

parasympathetic blockade

pentylenetetrazol

premature ventricular

(104) contractions

8667 sinus bradycardia

(107)

(108)

86848684

8684

8717

8717

8717

8717

8717

87178717

8717

8717

8717

8717

8691

8691

86918675

8688

8691

8691

8691

8684

8691

8675

8688

8675

8675

8684

8691

8691

8688

8684

8688

8688

8688

8674

8684

8691

8688

8691

86748688

86888688

8691

86 75.

1962

SUBJECT INDEX

S-ll

sinus tachycardiaventricular fibrillation

ventricular tachycardia

HEART AURICLES


chronotropic effects

DCI pretreatment

epinephrine

inotropic effects

isolated cat auricles

nicotine pretreatment

N-oxide analogs



SKF-6890A pretreatment

HEART, ISOLATED

acetylcholine

acute hemorrhage

adrenalectomyaldosterone

arterial pressure

atropine


bretyl ium

cardiac arrhythmias

carotid blood pressure

cat hearts

competence tests

contraction amplitude

coronary flow

coronary perfusion


DMPP


N-ethyl -nortropine-

benzhydryl -ether

guanethi dine

heart rate

8691


inotropic effects

isolated cat heart

isometric systolic tension

left atrial pressure

McNeil -A-343

negative chronotropic effect

norepinephrine

norepinephrine content

norepinephrine response

open-chest rat preparation

pentobarbital-induced failure

HEA-HEA

pentylenetetrazol effect 8684

perfused rabbit heart 8676

perfused rat heart 8677

phosphorylase a activity 8691

physostigmine 8691

posterior pituitary hormone 8677

pulmonary arterial pressure 8688

rabbit heart 8674

reserpine pretreatment 8688

retama 8676

right atrial pressure 8688

S-A pacemaker sensitivity 8688

systemic output 8688

tremorine 8674

vagal stimulation 8691

veratramine 8688

work capacity 8688

HEART MUSCLE, ISOLATED (109)

aldosterone 8675

cardiac arrhythmias 8684

cardioactive glycosides 8685

cat atrium 8685

cat papillary muscles 8675

8684

contraction amplitude 8684

contraction force 8675

dose-response curves 8684

electrograms 8684

frequency-force relationship 8685

guinea-pig ventricle 8685

heart rate 8684

inotropic effects 8675

isolated cat auricles 8684

isolated cat heart 8684

myograms 8684

ouabain 8675

parasympathetic blocking

agents 8684

pentylenetetrazol 8684

pH values 8675


rabbit atrium 8685

rabbit ventricle 8685

SC-8lO9 8675

tetrahydrocortisol 8675

Tyrode-solution incubation 8685

ventricular threshold 8684

HEART RATE (110)

atropine effect 8674

bradycardia 8674

C6-C14 tissue concentration 8713

8716

8688

8688

8674

8713

8688

8688

8688

8716

8674

8674

8674

VOL. 135

8669

8705

8669

8669

8686

8686

8686

8702

8686

8686

8702

8686

8686

8686

8702

8686

8702

(116)

(117)(112)

(113)

8 701

8 701

8672

8714

(118)

8686

8720

8720

8720

8720probenecid influence

8672 Gamma-HYDROXYBUTYRATE, SODIUM

albino mice (119)8705

behavioral studies 8705

8713 blood pressure 8705

8713 CNS depressant 8705

8713 EEG 8705

8713 heart rate 8705

8713 lethal toxicity 8705

8713 pentobarbital comparison 8705

8713 5-HYDROXYTRYPTAMINE (120)

871387138713

87138713

87138713

86678714

86678667

866786678714

8714

SUBJECT INDEX

S-12

HEA-HYD

cyclopropane effects


guanethidine

hexamethonium effect

hexamethonium-C 14

isolated dog heart

norepinephrine response

reserpine

tachycardia

tetraethylanznonium

tremorine

vagus nerve stimulation

8713

HEMOSTASISalbino rats

polymyxin B-induced

gastric hemorrhage

HEPARIN

blood arginine esterase

activity

human subjects

}LEXAMETHONIUN

ACh responses

blocking action

DFP-induced postgangl ionic

discharge

differential ganglionic

blockade


preganglionic nerve

stimulation

8673sympathetic ganglia

8673HEXANETHONIUM-N-METHYL-C]-4 (114)

anesthetized cats

autoradiograms

blood pressure

distribution volume

ganglion blockade

ganglion concentrations

intravenous administration

nephrec tomy


pharmacological activity

plasma concentration

pupillary light response

renal clearance

tissue distribution

tissue/plasma ratios

urinary excretion

HEXOBARBITAL HYPNOSIS (115)

DMHP effect

gamma-hydroxybutyrate

MOP effect

sleeping time

8705

HISTAMINEanesthetized chickens

bioas says

compound 48/80 injection

hemorrhagic lesions

histamine injection

oxytocin injection

(111) rat stomach

8702 serotonin injection

tryptamine injection

8702 urinary excretion

HISTAMINE LIBERATIONalbino rats


gastric ulcer formation

polymyxin B-induced

gastric hemorrhage 8702

serotonin- induced

vasodepression 8686

8672 tryptamine-induced

vasodepres sion

8673 HYDROCHLOROTHIAZIDE8714 acetazolamide combination

antidiuretic effect

8672 diabetes insipidus

8713 albIno rats

8713 anesthetized cat

bioassay

brain content

8707CNS depressants

fluorimetric assay

ganglionic blocking agents

ganglionic receptors

ganglionic stimulant action 8714


8711

8711

8711

8711

( 1 25)

(126)

(127)

( 1 28)

87118711

8711

8718

8718

8718

8718

8718

8718

8718

(129)

HYD-ISO

8669

8669

8676

8670867686768670

8670

8676

86708676

8708

8708

87038703870387038703

8719

87198719

8719

8719

8719

866486648664

866486648664866486648664

86648664

8692

869286708670869286928670

(130)

8704

8704

8704

8704

8704

8704

8675

8717

8717

8717

8717

8675

8675

8717

8675

8717

8675

(132)

(133)

1962SUBJECT INDEX

5-13

intraperitoneal

administration 8667

morphine tolerant animals 8707

nalorphine-induced abstinence 8707

HYPERGLYCEMIA (121)

adrenalectomy

adrenergic blockade

2 , 2 ‘ -bipyridine induced

blood glucose

dihydroergotamine

pretreatment

edathamil calcium disodium

pretreatment

fasted rats

ferrous iron pretreatment

pentobarbital -morphine

pretreatment

spinal transection

zinc pretreatment

HYPERTENSION, EXPERIMENTAL (122)atherogenic diet

body weight

male rats

mecamylamine effect

reserpine effect

serum cholesterol level

systolic pressure

HYPNOTICS (123)action duration

albino mice

chloral hydrate

depression stages

intraperitoneal injection

intravenous injection

neurological state

trichloroethanol

INOTROPISM (124)

aldosterone

cat papillary muscle

catecholamine release


isolated cat auricles


ouabain

N-oxide analogs

pH values


SC-8l09

INTESTINAL MOTILITY

cat small intestine


INTESTINE, ISOLATEDatropine effect


motility

muscle strips

rabbit ileum strips


retama

sympathomimetic amines

8711 tone changes

INTESTINE, SMALL

8711 catecholamine content

8711 morphine-tolerant animals

8711 INULIN-H3


CSF-blood transport



urinary excretion

IODOACETATEcontraction rate

prolonged stimulation

ryanodine pretreatment

skeletal muscle relaxation

stimulation frequency

twitch contraction height

IPRONIAZID

8704 MAO inhibitor activity

8704 NQS effect


ISOCARBOXAZID (131)

alkylhydrazid analdgs

BZH formation



NQS influence


ISOPROPYLHYDRAZINE



ISOPROTERENOL


DCI pretreatmentinhibitor activity


perfusion pressure

pulmonary arterial pressure


ISO-MER

ventilation overflow

KIDNEY (134)

creatinine clearance


meral luride

mercurial diuretics

nondiuretic mercurials

perfusion pressure

renal blood flow

urine flow

water excretion

LIPID-SOLUBILITY (135)


CSF-blood transport


LIVER DAMAGE (136)

acute ethanol intoxication

albino mice

chloroform induced

function tests

histopathologic examination 8699

LIVER FLUKE (137)

adenosine-3 ‘ , 5 ‘ -phosphate

formation

VOL. 135

8692 LYSERGIC ACID DIETHYLAMIDE (140)

blocking action 8714


8681

8681 MANNITOL (141)

8681 CSF-blood transport 8703

8681 intrav#{233}ntricular injection 8703

8681 urinary excretion 8703

8681 MECAMYLAMINE (142)8681 ACh responses 8672

8681 DFP-induced postganglionic

8681 discharge 8672

experimental atheromatosis 8718

hypertensive rats 8718

8703 hypocholesterolemic effect 8718

8703 hypotensive activity 8718

8703 normotensive rats 8718

oral administration 8718


8699 potentials 8672

8699 sympathetic ganglia 8672

8699 MEPERIDINE (143)

brain 5-HT content 8667

cerebral cortical slices 8700

cross-cellular adaptation 8700

8679 morphinized rats 8700

8679 MEPROBAMATE TOLERANCE (144)

8679 development mechanism 8695

8679 male albino rats 8695

8679 MEPROBAMATE-C14 (145)

8679 blood levels 8695

8679 brain levels 8695

8679 daily administration 8695

8679 excretion rate 8695

8679 fat levels 8695

8679 fecal excretion 8695

8679 intraperitoneal injection 8695

8679 male albino rats 8695

8679 meprobamate-pretreated

animals 8695

8699 metabolic inactivation 8695

8699 muscle levels 8695

8699 nontolerant animals 8695

8699 tolerance development 8695

urinary excretion 8695

8699 urinary metabolite excretion 8695

whole body activity 8695

8677 MERCURIAL COMPOUNDS (146)

8677 renal circulation 8681

8677 renal perfusion pressure 8681

aerobic glycolysis

anaerobic glycolysis

enzyme activity

fasciola hepatica

glucose utilization

glycolytic enzyme systems

hexosephosphate concentration

homogenate preparations

intact parasites

lactic acid production

phosphofructokinase activity

serotonin effect

substrate effect

LIVER FUNCTION (138)

albino mice

BSP retention

chloroform pretreatment

ethanol pretreatment

succinic dehydrogenase

activity in vitro

LOBELINE (139)anesthetized rats

antidiuretic activity

vasopressin release

SUBJECT INDEX

S-l4

urinary sodium concentration 8681

urine flow 8681

8681

(147)

(155)

86818680

8680

8681

8681

MER-MOR

______ 8665

8664

8664

8664

8664

heart 8665

iproniazid inhibition 8664

ISH inhibition 8664

isocarboxazid inhibition 8664

rat liver mitochondria 8664

sympathetic ganglia 8665

tissue homogenates 8665

MONOAMINE OXIDASE INHIBITORS

brain 5-HT content (156)8667

8706

8667

(149)

8704

8704

8693

8709

8709

8693 morphine-tolerant animals

morphine-tolerant rats

non-hydrazine derivatives

NQS effect8693

8704

8709

8709

8693

8664

8664

8708

8706

8664

8664

8706

rat liver mitochondria 8664

tissue catecholamines 8708

MORPHINE (157)

adrenal catecholamine content 8706

8709

8693

8704

8693

8698

8698

8698

8698

(152)

(153)

(154)

8667

8714

8706

8707

8706

8667

8708

8678

8678

8706

8700

8700

8706

8706

8714

8667 chronic administration

8667 8707 8708


8680 depression adapted rats

8680 excitatory abstinence

8669 experimental animals

8669 ganglionic stimulants

1962

SUBJECT INDEX

S -15

vasoconstrictor activity

MERCURIALS , NONDIURETIC


inhibitor activity

mercurial diuresis

perfused kidney

water excretion

IIERSALYL (148)

#{163}-CMBreversal 8680diuretic response 8680

mercuric chloride: glutathione 8680

8680methyl mercury chloride

METABOLISM, DRUGalbino mice

chloral hydrate

conjugate formation

cotinine

desmethylcotinine excretion

ll� -dichloroi soproterenol

3 ,4-dichloromandelic acid

format ion

enzymatic reduction

human subjects

hydroxycotinine

oxidative deamination

gamma-(3-pyridyl) -beta-N-oxo-

methylbutyramide

tissue distribution

trichloroethanol formation

urinary metabolites

8709

METAGLYCODOL (150)amphetamine mortality

antagonist activity


mouse strains

METHADONE (151)

cerebral cortical slices 8700

cross-cellular adaptation 8700

morphinized rats

METHAZOLAMIDEbrain 5-HT content

carbonic acid inhibitor

METHYL MERCURIC CHLORIDEmercurial diuresis

nondiuretic . mercurial

METHYL-OCTYL-PYRAN (MOP)

chemical structure

pharmacological effects

MONOAMINE OXIDASE

activity assay in vitro

aerobic preincubation

anaerobic preincubation

BAR-induced inhibition

�-dimethylaminobenzyl

hydrazine inhibition

brain norepinephrine content

harmal me

hydrazine derivatives

i socarboxazid


(JB 516)

8708

albino rats

8678

blocking action

body temperaturebrain gamma-aminobutyric acid

brain catecholamine content

brain 5-HT content

8707

cardiac catecholamines

cellular adaptation

8700 cerebral cortical slices

8700

syndrome

MOR-NAL

8708

8708

8700

8700

8708

8706

8678

8707

8706

8706

8707

8708

87088706

VOL. 135

8692

8692

8686

8686

8686

8692

8686

8686

8686

8715

8671

8671

8698

8698

8698

8698

8698

8698

8698

8698

8698

8698

8698

8715

8692

8692

8692

8686

8686

8692

8692

8692

8686

8686

8685

8685

8685

(159)

8719

8719

8719

8719

8719

8719

8719

8719

8719

8719

8719

87198719

8678

8678

8700

8700

8678

8678

8700

86788700

8678

SUBJECT INDEX

5-16

intestine catecholamines

JB-5l6 effect

meperi dine

methadone

morphine-induced convulsions

nalorphine effect

8708

nalorphine reversal

nalorphine-induced abstinence

pentobarbital anesthesia

sedation

single doses

8708

splenic catecholamines

tissue norepinephrine

tolerance effects

8707 8708

withdrawal response

MOUSE STRAINS (158)

aggregated animals

amphetamine mortality

anticonvulsant effects

drug antagonists

drug susceptibility


isolated animals

mixed strains

mortality determinations

strain difference

variable responses

MUSCLE, SKELETAL

acid-extract analysis

ATP levels

contraction rate

creatine phosphate levels

frog sartorius

L-alpha-GP levels

IAA rigor

iodoacetate effect

prolonged stimulation

relaxation mechanism

relaxation rate

ryanodine effect

ryanodine rigor

ryanodine-IAA effect

stimulation frequency

twitch contraction height

MUSCLE, SMOOTH (160)acetylcholine response

8715


bronchioles


chicken urine-samples

compound 48/80 treated

chickens



guinea-pig ileum

histamine treated chickens

intestinal strips

isolated rabbit aorta

“muscarinic” receptors


8690

norepinephrine content 8690

pressor substance

pretreatment

8678 pulmonary vasomotor responses

alpha-receptors

beta-receptors

serotonin desensitization

serotonin treated chickens

sympathetic nerve stimulation

sympathomimetic

bronchodilators

tolazoline pretreatment

tripelennamine blocking

action

tryptamine treated chickens

MYOCARDIAL CONTRACTILITY (161)intact rabbit heart

8719 isolated heart muscle

8719 ouabain effect

8719 pentobarbital-induced

depression 8685


rate-dependent mechanism 8685

NALORPHINE (162)antagonist :agonist ratio

cerebral cortical cells



KC1-stimulated cortical

slices

morphine adaptation

morphinized rats

nalorphine-morphine

8671 combination

narcotics

8692 reversing action

NAP -OXY

(167)

8664 binding sitesbronchomotor responses

DCI pretreatment


8678 8671

8678 inhibitor activity

isolated aorta


membrane catecholamine

(165)

8700

8678

8700

8678

8677

8677

8677

8690

8713

8690

(168)

(169)

8671

8715

86908692

8692

8670

8670

8715

8670

8690

8671

8690

8671

8690

8670

8712

8712

8712

8712

8712

8712

8712

8712

8712

8712

8685

8675

8675

8675

8685

8685

8685

8678

8678

8700

8678

8700

8700

8678

8671

8690

8713

86718671

8690

8671

8690

8690

OUABAIN


inotropic action


8685

8671 pH values


“therapeutic” effect

8713 “toxic” effect

8671 OXYGEN CONSUMPTION (170)

albino rats

8671 cerebral cortical slices

8674 8700


8671 KC1-stimulatory response

8669 meperidine

8674 methadone

8669 morphine-induced cellular

8674 adaptation

1962SUBJECT INDEX

S -17

1 , 2-NAPHTHOQUINONE-4-SULFONATE

SODIUM (NQS) (163)

BZH-induced MAO inhibition

in vitro

isocarboxazid-induced MAO

inhibition in vitro 8664

NARCOTICS (164)

cellular adaptation


8700


in vitro

morphine tolerance

morphinized rats

nalorphine reversal

NICOTINE

anesthetized rats

antidiuretic potency

vasopressin release

NICTITATING MEMBRANE (166)

acetylcholine action 8671

anesthetized cats 8690

8713


C6-Cl4 ganglion concentration

contractile responses

8713


epinephrine sensitivity

hexamethonium-C 14

“muscarinic” receptorsnorepinephrine

norepinephrine sensitivity

phenoxybenzamine modification

postganglionic denervation

preganglionic denervation

preganglionic nerve

stimulation

8674

preganglionic sympathetic

stimulation


8690spinal cats

superior cervical ganglion

superior cervical

gangl ionectomy

sympathetic nerve stimulation

TEA pretreatment


tremorine effect

tyramine

NOREPINEPHRINE


content



sensitivity

phenoxybenzamine modification

removal mechanism


NUCLEIC ACID FRAGMENTS

adenines

cardiac nerve stimulation

cytidines

drug effects

heart muscle extracts

hypoxanthine

inosines

open-chest dogs

uridines

xanthine

morphinized rats 8700 subcutaneous temperature 8694nalorphine reversal 8678 “total” acetylcholine

activity 8696PAPILLARY MUSCLES (171) PENTOBARBITAL HYPNOSIS (175)

aldosterone 8675 albino mice 8699

antiarrhythmia agents 8684 chloroform pretreatment 8699

DCI pretreatment 8717 ethanol pretreatment 8699

epinephrine 8717 sleeping time 8699

inotropic effects 8675 PENTYLENETETRAZOL (176)

8717 cardiac arrhythmias 8684ouabain 8675 cardiac tissue 8684

N-oxide analogs 8717 concentration effect 8684

pentylenetetrazol 8684 convulsant threshold 8698

pyridine derivatives 8717 mouse susceptibility 8698

reserpine pretreatment 8717 parasympathetic blocking

SC-8109 8675 agents 8684

SKF-689OA pretreatment 8717 phenobarbital antagonism 8698PARASYMPATHETIC BLOCKING AGENTS strain difference 8698

N-ethyl-nortropine- (172) PHENOBARBITAL (177)benzhydryl-ether 8684 amphetamine mortality 8698

pentylenetetrazol-induced antagonist activity 8698

arrhythmias 8684 mouse strains 8698PARASYMPATHETIC NERVOUS SYSTEM, PHENOLSULFONPHTHALEIN (178)

GANGLION (173) CSF disappearance rate 8703blocking Effect 8713 intracisternal injection 8703

hexamethonium-Cl4 intraventricular injection 8703

concentration 8713 plasma levels 8703

tremorine inhibitor activity 8674 transport process 8703tremorine stimulant activity 8674 urinary excretion 8703

PENTOBARBITAL (174) PIPERACETAZINE (179)

acute toxicity 8694 amphetamine mortality 8698

anesthetized rats 8696 antagonist activity 8698

blood levels 8694 lethal effect 8698

brain concentration 8694 mouse susceptibility 8698

brain esters 8696 strain difference 8698

brain 5-HT content 8667 PLASMA (180)

brain-blood concentration catecholamine concentration 8716ratio

diffusion rate

8694

8694


H3-DCI concentration

8716

8693

distribution volume 8694 disappearance rates 8693

environmental temperature 8694 8713

gamma-hydroxybutyrate 8705 epinephrine concentration 8716

liver concentration 8694 fluorescence development 8710

liver-blood concentration fluorimetric determination 8710

ratio 8694 hexamethonium-C14

male rats 8694 concentration 8713

mortality rate 8694 human subjects 8710

oil-water distribution 8694 oral spironolactone

plasma protein binding 8694 administration 8710

rectal temperature 8694 spironolactone metabolite

sleeping time 8705 levels 8710

OXY-PLA

SUBJECT INDEX

VOL. 135

5-18

(185)

(186)

(187)

1962

SUBJECT INDEX

S -19

sulfuric acid-f luorogen

tissue/plasma ratios

POLYNYXIN B (181)

albino rats

drug antagonism

gastric hemorrhage production

gastric ulcer formation

histamine liberation

intraperitoneal injection

pylorus-ligated rats

subcutaneous injection

time-response curves

POSTERIOR PITUITARY HORMONE

(VASOPRESSIN) (182)

coronary blood flow

coronary vasoconstriction

ECG

isolated heart

lobeline-induced release

nicotine-induced release

PROCAINE (183)

ACh responses 8672

cervical sympathetic ganglion 8672


discharge 8672


potentials 8672

PUPIL (184)

carbachol pretreatment

hexamethonium pretreatment

phenoxybenzamine pretreatment

tremorine-induced mydriasis

PYRIDINES


cardiac effectscatecholamine release


methyl derivatives

nicotine pretreatment

N-oxide analogs

PYRILAMINE

polymyxin B-induced

gastric hemorrhage

protective effect

REFLEXES

flexion reflex

knee jerk

linguomandibular reflex


PLA-RET

8710 RESERPINE (188)

8713 blood-brain barrier 8666

epinephrine uptake 8666

8702 experimental atheromatosis 8718

8702 guanethidine comparison 8688

8702 hypertensive rats 8718

8702 hypocholesterolemic effect 8718

8702 hypotensive activity 8718

8702 inhibitor activity 8666

8702 isolated mammalian heart 8688

8702 isolated rabbit ileum 8670

8702 normotensive rats 8718

oral administration 8718

organ sensitivity 8670

8677 pretreatment effect 8670

8677 special CNS areas 8666

8677 sympathomimetic amines 8670

8677 RESORCINOL ISOMERS (189)

8677 arterial pressure responses 8689

8677 cardiac contraction force 8689

cardiovascular system 8689

open-chest dogs 8689

spinal cord action site 8689

sympathetic stimulatory

effect 8689

RESPIRATION (190)

anesthetized cats 8669

carotid sinus denervation 8676

8674 hexamethonium blockade 8676

8674 rate changes 8669

8674 respiratory paralysis 8669

8674 retama stimulatory action 8676

tetrahydrocannabinols 8669

8717 RETAMA (191)

8717 adrenalectomy 8676

8717 adrenergic blocking agents 8676

8717 anesthetized dogs 8676

8717 atropine pretreatment 8676

8717 B-TM-lO pretreatment 8676

8717 cardiovascular actions 8676

carotid sinus denervation 8676

hexamethonium blockade 8676

8702 hexamethonium pretreatment 8676

8702 isolated intestine 8676isolated uterus 8676

peripheral actions 8676

phenoxybenzamine pretreatment 8676

8669 respiration 8676

8669 smooth muscle 8676

8669 sympathectomy 8676

8669 vagotomy 8676

(193)

RYA-SYM

RYANODINE

alpha-glycerokinaseL-alpha-GP dehydrogenase

iodoacetate effect

skeletal msucle relaxation

SACCHARIDES 14


CSF disappearance rates


intravenous injection


plasma levels

urinary excretion

SALIVARY SECRETION (194)

atropine blockade

chorda tympani section

hexamethonium

submaxillary gland

tetraethylammonium blockade

tremorine-induced salivation

SEROTONIN (195)acetylcholine response


aortic chains


glycolytic enzyme activity

histamine depleted animals

histamine release

pressor response

intact parasites

liver fluke homogenates

vasodepressor response

SPINAL CORD (196)action site

acute transection

resorcinol isomers

sympathetic circulatory

stimulation

SPIRONOLACTONE (ALDACTONE) (197)

de-thioacetylated derivative

(SC -9376)fluorimetric determination

human subjects

oral administration

plasma metabolite levels

plasma sulfuric acid-

fluorogen

SC-9376 structural

relationship

SUBJECT INDEX

S -20

VOL. 135

(192) SPLEEN (198)

8719 catecholamine content 8708

8719 morphine-tolerant animals 8708

8719 STOMACH (199)

8719 albino rats 8702

atropine 8702

gastric secretion 8702

hemorrhagic lesions 8702

8703 histamine 8702

8703 histamine content 8702

8703 polymyxin B 8702

8703 pylorus-ligated rats 8702

8703 serotonin content 8702

8703 STRYCHNINE (200)

8703 lethal effects 8698

mephenesin antagonism 8698

8674 meprobamate antagonism 8698

8674 mouse susceptibility 8698

8674 strain difference 8698

8674 SUCROSE (201)

8674 CSF-blood transport 8703

8674 intraventricular injection 8703

urinary excretion 8703

8715 SULFONAMIDES (202)

8686 antidiuretic activity 8720

8715 diabetes insipidus 8720

8715 metabolic responses 8720

8679 saliuretic compounds 8720

8686 structure action relationship 8720

8686 urinary electrolyte excretion 8720

8686 urine volume 8720

8679 water intake 8720

8679 SYMPATHETIC NERVOUS SYSTEM (203)8686 brain norepinephrine function 8706

bronchomotor response 8692

8689 cardiovascular reflexes 8668

8689 cardiovascular stimulation 8689

8689 central administration 8668

DCI pretreatment 8692

8689 guanethidine effect 8668

intravenous administration 8668

morphine-tolerant animals 8706

8710 resorcinol isomers 8689

8710 spinal cord action site 8689

8710 splanchnic nerve activity 8668

8710 thoracic postganglionic

8710 stimulation 8692

SYMPATHETIC NERVOUS SYSTEM,8710 GANGLION (204)


8710 anesthetized cats 8672

8673

DCI reversing action 8692atropine effect 8672 pulmonary arterial injection 8692

bioassay 8665 sympathetic nerve stimulation 8692

blocking effect 8713 ventilation overflow 8692

cell group responses 8673

chronic denervation 8672 TEMPERATURE, ENVIRONMENTAL (208)

DFP effect 8673 barbital distribution 8694DFP-induced postganglionic barbital toxicity 8694

discharge 8672 male rats 8694differential blockade 8673 pentobarbital distribution 8694epinephrine content 8690 pentobarbital toxicity 8694

external carotid nerve 8673 TEMPERATURE, RECTAL (209)

functional heterogeneity 8673 barbital distribution 8694

ganglionic blocking agents 8672 barbital toxicity 86948673 male rats 8694


hexamethonium-C14pentobarbital distribution

pentobarbital toxicity

8694

8694

concentration 8713 TETRAETHYLAMMONIUN (210)

intra-arterial injections 8672 ACh responses 8672

8673 chronic denervation 8672MAO activity 8665 DFP-induced postganglionic

norepinephrine content 8690 discharge 8672

postganglionic action differential ganglionic

potentials 8673 blockade 8673

preganglionic nerve dose effect 8673

stimulation 8672 postganglionic action

8673 potentials 8673

preganglionic section 8690 preganglionic nerve

procaine effect 8672 stimulation 8672

reserpine pretreatment 8690 repetitive preganglionic

retama stimulatory effect 8676 stimulation 8673

superior cervical ganglion 8672 sympathetic ganglia 8672

8673 8690 8673

through fibers 8673 TETRAHYDROCANNABINOLS (211)

thyroid nerve 8673 action site 8669

d-tubocurarine effect 8672 amphetamine-induced activity 8669

SYMPATHETICO-ADRENAL SYSTEM(205) anesthetized cats 8669

anesthetized dogs 8716 atropine pretreatment 8669

cyclopropane responses 8716 blood pressure 8669

nictitating membrane 8716 carotid sinus denervation 8669

pupil diameter 8716 decerebrate cats 8669

SYMPATHOMIMETIC AMINES (206) dibenamine pretreatment 8669

dose-response curves 8670 intestinal motility 8669

inhibitor activity 8670 nictitating membrane 8669

isolated rabbit ileum 8670 pharmacological effects 8669

organ sensitivity 8670 piperoxan pretreatment 8669

reserpine pretreatment 8670

SYMPATHOMIMETIC BRONCHODILATORS

reflexes

respiration

8669

8669

anesthetized dogs (207)8692 spinal section 8669

arterial perfusion pressure 8692 toxicity 8669

bronchomotor responses 8692 vagotomy 8669

1962

SUBJECT INDEX

SYM-TET

S -21

histamine release

8674 pressor response

8674 vasodepressor response

d-TUBOCURARINE

8686

8686

8686

(217)

8672

8672

8672

8672

8672

(218)

8670dose-response curves 8671

inhibitor activity 8670

isolated rabbit ileum 8670

8672 nictitating membrane 8671

phenoxybenzamine modification 8671

8672 reserpine pretreatment 8670

8672

8674 (219)

8674 8676

8674 8676

86748674

8674 (220)

8674 8715

isolated aorta 8715

8674 VASODEPRESSION (221)

8674 anesthetized chickens 8686

histamine mediated mechanism 8686

8704 serotonin response 8686

8704 tryptamine response 8686

8704 VASODILATORS (222)

8704 acetylcholine activity 8715

8704 isolated aorta 8715

VASOMOTOR SYSTEM (223)

8686 central inhibition 8668

8686 guanethidine effect 8668

( 214)

(215)

TRA-VAS

SUBJECT INDEX

VOL. 135

S -22

TRANSMISSION, GANGLIONIC (212)

anesthetized cats

DMPP response


postganglionic discharge 8674

superior cervical ganglion 8674

tremorine 8674

TRANSMISSION , SYMPATHETIC

GANGLIONIC (213)



discharge 8672

ganglionic blocking agents 8672

intra-arterial injections 8672


potentials

preganglionic nerve

stimulation

presynaptic terminals

TREMORINE

action sites

anesthetized dogs

autonomic effects

biphasic effect

cardiovascular system

cholinesterase inhibition

hypothermic response

peripheral ganglionic

activity

urinary bladder

TRICHLOROETHANOL

albino mice

brain tissue concentration

chloral hydrate comparison

chloral hydrate metabolite

hypnotic activity

TRYPTANINE (216)


histamine depleted animals

acetyicholine responses


di scharge

intra-arterial injection

preganglionic stimulation

sympathetic ganglia

TYRANINE

action mechanism

UTERUS

isolated guinea-pig uterus

re t ama

VASOCONSTRICTORS

acetylcholine activity

8719

8677

8688

86678696

8687

8687

8682

8714

8667

8667

8709

8669

8703

8702

8686

Paasonen N K

Page I H

Penna M

Phillips B N

Plaa C L

Price H L

8716

Prockop L D

Robb J S

Rossi C V

Schanker L S

Schmidt J L

8707 Schneider J A

8668 Schoepke H G

8711 Schwartz M A

8698 Seraydarian M W

8690 Setnikar I

8706 Shanfeld J

Shideman F E

8688 Sjoerdsma A

8699 Smith C N

Smith T H F

8690

8704

8684

8720

8669

8716

8705

8676 8668

8713

8704

87098683

8679

8687

8693

8706

8678

86758694

8720866686718685

86818672

86868689

8698872086978666

Vargas R

Volle R L

8673

Walaszek E J

Walton R P

Weaver L C

Welsh M

Widdicombe J

Wilson C W M

1962

AUTHOR INDEX

VOL. 135

Nelson E 8682 Yim G K W 8695

Abbott B C

Allmark M G

Alper M H

Anderson E G

Ara R

Aramendia P

Aviado D M

8692

Ballard B E

Bindler E

Bonnycastle D D

Bonnycastle N F

Bowman E R

Boyd E S

Brodie B B

Brodie D A

Bunag R D

Cafruny E J

Castro de la Mata

8687 8692

Cervoni P

Cooper J R

Covino B G

Crawford J D

Dagirmanjian R

Deutsch S

Drakontides A B

Dunn M J

Easton N R

Farah A E

8685Fleming W W

Floch M H

Friedman A H

Frost L

Funderburk W H

Furchgott R F

Gantt C L

Gatgounis J

Gillen W

Gochman N

Grewal R S

Groisser V W

Gyermek L

Haugaard N

Hess M E

Hilton J C

Hosein E A

Jelliffe R W

Jenden D J

Kaji H K

Kaneko Y

Kenny A D

Kerley T L

Kirpekar S N

8681 Klingman C I

R 8707 8708

Krayer 0

Kutob S D

Levine R J

Linde H W

Lovenberg W

Lu F C

McCubbin J W

Mclsaac R J

8683 Mackay F J

McKennis H JrMcMahon R E

8680 Mansour T E

Martinez

8670 L de Letona J

8701 Mayer S E

8674 Maynert E W

8720 8707 8708

8705 Miller T B

8690 Miya T S

Noreno 0 M

Morey E R

8710 Murray A W

8689

8684

87108677

8701

8714

8691

8691

8676

8696

8715

8719

8665

8716

8665

8677

8680

8695

8702

8711

8666

Takemori A E

8700

Tanz R D

Temelcou 0

Terry N L

Titus E

Trendelenburg U

Tuttle R S

8688

8668

8692

8695

8699

8697

8703

8712

8718

8703

8670

8705

8717

8664

8719

8694

8691

8717

86658674

8718

1962 NOTICE VOL. 135

to Subscribers and Readers

Because of the comprehensive nature of the Journal index, the following

explanatory comment, with special reference to subject analysis, seems

appropriate at this time.

Subject Content: This is available to the reader by simple, coordinate

search of the Subject Index. Coincident display of pertinent headings and

subheadings, arranged alphabetically, assures the searcher that significant

information will not be missed. The information thus acquired may be divided

into three categories:

First: The Number of Articles Cited on Each Subject.

Rapid survey of the entry numbers listed opposite the subheadings will

indicate the scope and variety of topic coverage. The subheadings describe

the subject content in unit terms, with separate access for each idea.

For the convenience of direct page reference, AUXILIARY INDEX-PART I

presents a table of Index to Pages.

Second: The Number of Subjects Covered in Each Article.

The Subject Index admits topic headings according to the relative impor-

tance of competing information within each article By the liberal use of

these selected headings, numbered serially in parenthesis, a convenient sys-

tem of complete cross-reference is provided for the reader.

For the purpose of cross-reference, AUXILIARY INDEX-PART II is recommended.

It presents a table of index to Subject Headings, in which the heading

numbers appear below the appropriate underscored entry numbers. The corres-

ponding headings may be quickly located by reference to the parenthetic

heading numbers in the subject index.

Third: The Associations of Ideas Related to the Subject of Search.

Ready comparison of ideas described under one heading with those listedunder the alternative headings will often lead to a fund of relevant facts.

In this manner, tracing ideas through the total system should open the way

to useful material that is beyond the limits of restricted fields of inquiry.

MARCH

Auxiliary Index-Part I

Index to Pages

VOLUME 135, 1962

JANUARY FEBRUARYEntry � Entry

8664 1 8684 136

8665 7 8685 142

8666 11 8686 1518667 17 8687 156

8668 21 8688 164

8669 25 8689 174

8670 34 8690 180

8671 39 8691 191

8672 45 8692 197

8673 54 8693 204

8674 62 8694 213

8675 71 8695 223

8676 79 8696 230

8677 84 8697 233

8678 89 8698 240

8679 94 8699 245

8680 102 8700 252

8681 112 8701 256

8682 120 8702 259

8683 128

Entry

8703

8704

8705

8706

8707

8708

8709

8710

8711

8712

8713

8714

8715

8716

8717

8718

8719

8720

266

271

275

285

296

300

306

312

317323335344

349

354

358

367374

382

Al -1

1962 Auxiliary Index-Part II VOL. 135

Index to Subject Headings

8664 8669 8673 8678 8685 8691 8698 8703 8709 8715

30 36 204 39 4 89 177 51 66 21

130 50 210 49 44 108 179 70 149 91

131 78 157 64 200 128 160

132 115 8674 162 75 8692 135 8710 167

155 125 34 164 109 7 8699 141 180 195

156 154 36 170 161 73 9 178 197 220

163 166 62 169 91 54 193 222

187 81 8679 133 89 201 8711

� 190 108 89 � 160 93 6 8716

32 211 110 98 36 167 136 8704 33 36

89 166 102 116 203 138 39 37 45

105 � 173 137 117 207 175 53 50 48

155 90 184 195 160 123 52 67

204 91 194 195 � � 149 76 86

126 212 8680 216 39 39’ 215 121 110

� 133 214 55 221 74 49 180

39 167 56 149 143 8705 8712 205

50 188 � 82 � 180 151 39 105

92 206 8 96 22 157 50 168 8717

188 218 10 147 40 8694 162 87 48

108 148 79 26 164 115 8713 105

� � 109 153 100 174 170 119 36 10727 3 124 208 174 39 124

32 63 169 8681 8688 209 8701 99 171

39 160 171 55 103 29 8706 110 185

43 166 84 108 8695 35 5 114 �2J�50 167 � 134 110 144 89 38 166 20

53 218 36 146 188 145 112 39 173 36

80 108 147 48 180 61

95 8672 126 8689 8696 8702 156 204 122

104 3 190 � 36 3 16 157 142

120 23 191 1 45 15 17 203 8714 188

143 77 204 85 105 39 19 23

152 99 219 189 94 58 8707 24 8719

156 113 8683 196 174 60 11 31 129

157 142 8677 42 203 68 39 41 159

174 183 36 69 8697 72 120 63 192

204 65 89 8690 36 91 157 72 8720

� 210 83 48 46 101 79 2

36 213 86 8684 160 47 111 99 18

50 217 108 97 166 67 116 8708 100 28

103 139 106 167 117 48 113 57

203 �21 165 108 204 8698 181 105 120 59

223 3 182 109 13 186 127 140 71

99 171 �2i 150 199 156 157 88

8669 100 8678 172 25 158 8703 157 8715 118

12 113 14 176 45 176 35 198 3 202

AI-2

NOTICE

to Subscribers and Readers

Attention is directed to the current method (ACC) of using entry numbers

opposite the unit terms and names comprising the Subject and Author sections

of the Journal Index. These entry numbers coincide with the appropriate ac-

cession numbers listed serially at the left of the titles in the Register of

Articles. Their purpose is to condense and unify the three parts of the in-

dex, and to expedite its use.

For a brief guide to the use of the current index please consult pages

AI-l, and AI-2. Objectives and method are discussed under Notice to Readers

and Subscribers.

For direct page reference, an Index to Pages by entry numbers is tabulated

on page AI-l.

For cross-reference of subject matter, an index to Subject Headings by

entry numbers is presented on page AI-2.

The possibility has been considered that additional copies of the index,

bound separately, might be of value to libraries and to other subscribers

and readers for use in reference work. Such a separate distribution would

be justified only if the sale of a significant number of copies could be

assured. It is suggested that anyone interested in such separate indexes

write a letter to the Publisher who can then determine the feasibility of

separate distribution.

AI-3

subjectindex 1962...

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