stereotactic breast biopsy design and testing · localization accuracy test (in air) phantom image...
TRANSCRIPT
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Stereotactic Breast BiopsyDesign and Testing
Robert J. Pizzutiello, Jr., F.A.C.M.P.Upstate Medical Physics, Inc.
716-924-0350
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Overview
uWhat is a SBB?u Purpose of ACR-SBBAPu Requirements for accreditationu Technologist’s QC Testsu Medical Physicists QC Tests
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Detection vs. Diagnosisu Detection
BSEPhysician Physical ExamMammographyUltrasound
u Tissue DiagnosisBiopsyCytologyHistology
333
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SBB- Imaging andDose Considerations
u Localization (not detection) ofabnormalities
u Limited numbers of “normals”u Complex backgroundu Microcalcifications, massesu Limited FOV neededu Radiation risk to selected “at risk”
population
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SBB X-ray Systemsu Dedicated prone units: similar to
Diagnostic Mammography Unitsu Smaller FOV required, 16o target
angleu Light Field may be replaced by two
illuminating lampsu SID may be longeru AEC may or may not be available
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Types of SBB Equipment
uDedicated prone tablesuAdd-on stereo unitsuScreen-film imaginguDigital Image receptors
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The CCD ImageReceptor
The CCD ImageReceptor
u Charge-Coupled Deviceu An integrated circuit (chip)
silicon wafer
u About the size of a postage stampu Converts light into electronic
image
detectors
amplifiers
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LGE NL 11-22-96 #4
CCD ImageReceptors
CCD ImageReceptorsu5cm x 5cm FOV CCD, typical
uLoRad DSM (below) 5 cm x 5 cmuGE Senovision (right) 8 cm x 8 cm
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Display Gradient
1 2 5 10 20 50 1000
0.05
0.1
0.15
0.2
0.25
0.3
Relative Exposure
Gra
dien
t
Characteristic Curve
1 2 5 10 20 50 1000
1
2
3
4
Relative Exposure
Opt
ical
Den
sity
Higher Film Contrast means less tolerance for exposurevariation
Exposure Latitude
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Conventional x-rayexposure creates an aerialimage
Readout CCD to computer
Minify light image to CCD size
Intensifying screen convertslatent x-ray image to visiblelight image
Display, manipulate, archivedigital image
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Side View
Focal Spot X-rayTube
Small areaCollimator
CompressedBreast
Phosphor
Mirror
CCD
Front View
DMAA/D
Optical coupling/mirror systemLight reflection from phosphor
Lens
CCD
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Side View
Focal Spot X-rayTube
Small areaCollimator
CompressedBreast
PhosphorFiber Optic
CCD
Front View
DMAA/D
2:1 fiberoptic taper demagnificationLight transmission through phosphor
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Digital Image Quality
u Contrastu Bluru Noiseu Artifactsu Dose
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Factors Affecting BreastDoseu kVp, mAs
u exposure time (film only)u breast thicknessu breast composition (dense or fatty)umultiple exposures
u digital image processing does NOT affectdose
u optical density of film (if hardcopy is used)does NOT affect dose
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To Minimize Breast Doseu Develop and maintain a good technique chartu Obtain manufacturer’s suggested techniquesu Evaluate image quality at different mAs values
(Technologist and Medical Physicist)u Moderately higher mAs will reduce image
noise, but increase doseu Insufficient mAs will produce a noisy (grainy)
image, but can be made to appear “wellexposed” with window/level control
u Excessive mAs images may also appear “OK”with window/level adjustment
u Minimize retakes
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Principle ofStereotacticLocalization
u2-D localization -planar view
u3-D localization -triangulation neededfor depth coordinate
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Our first exposure to StereoLocalization Techniques
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How many pins are left?
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The origin of the 15o stereo shift?
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+ 15° - 15°
+ 15° View - 15° View
+ 15° - 15°
+ 15° View - 15° View
Before Lesion After Lesion
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Methods of ImagingGuided Breast Biopsy
u Ultrasound guided, hand-held needleu Stereotactically guided core biopsy
Not visible on ultrasoundLocalize with millimeter precision
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Core Biopsy
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ACR-SBBAPHistory
u Committee convened Fall, 1995Develop professional standardsDevelop SBBAP materials for facilities
u Pilot program 1st quarter, 1996u Announced at ACR Breast Cancer
Meeting (April, 1996)u Reviewers trained
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ACR-SBBAPu Modeled after ACR-MAPu 1996 vs. 1987u Personnel qualificationsu Equipment performanceu QCu Procedure verification
(through clinical image evaluation)u Image quality (phantom images)u Dose
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Personnel QualificationsMedical Physicist
u Board Certification or alternate requirementsu 15 hours CE in Mammo Physics every 3 yearsu < 6/1/97
3 hands-on SBB MP Surveys, or1 hands on SBB MP Survey under guidance ofQualified SBB MP
u > 6/1/971 hands-on SBB MP Survey under guidance
u At least 1 SBB MP Survey per yearu 3 hrs CE in SBB Physics every 3 years
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Physician Qualificationsvs.
Practice Model
Where a radiologist or surgeon (or otherphysician) are practicing independently, the
expertise in the diagnosis and management ofbreast disease of an individual physician mayprovide the patient with an equivalent benefit.
In a collaborative practice, the patient derives thebenefit of consultation and collaboration from the
radiologist and surgeon (or other physician)working together.
Collaborative Independent
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Physician Credentialsu Mammogramsu SBBu Training, Experienceu Category I SBB coursesu QAu Radiation Physics Trainingu Supervision of RT and MPu Post biopsy recommendationsu Lesion identification at time of biopsy
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Approximate StatusSeptember, 1998
u 377 facilities appliedu 278 facilities accreditedu 382 units applied - activeu 105 units applied - pendingu 182 units accredited on initial attempt
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147 units with deficiencies oninitial evaluation
Clinical onlyClinical in combinationPhantom onlyPhantom in combinationDose
62 (42%)34 (23%)31 (21%) 4 ( 3%)16 (11%)
96 units passed after re-application
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The latest word...u No longer accepting optical disk or
diskette. Hard copy images only.u FDA will implement regulations
mandating accreditation of facilitiesif they do not comply voluntarily
u Check TLD technique (10% failurerate for dose)
u QC Manual available early 1998
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Darkroom CleanlinessProcessor Quality ControlScreen CleanlinessViewboxes & Viewing Conditions
Phantom ImagesVisual ChecklistRepeat AnalysisAnalysis of Fixer RetentionDarkroom FogScreen-Film ContactCompression
DailyDaily
WeeklyWeeklyWeeklyMonthly
QuarterlyQuarterly
Semi-annuallySemi-annuallySemi-annually
D (SF only)D (SF only)W (SF only)W (SF only)
WeeklyMonthly
QuarterlyQ-(SF only)S - (SF only)S - (SF only)
Semi-annually
Mammo SBB
QC Tests Common to Mammographyand SBB Minimum Testing Frequencies
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Zero Alignment Test(only on some units)
Localization Accuracy Test (in Air)
Phantom Image Quality TestHardcopy Output Quality(if hard copy is produced from digital data)
Visual Equipment CheckRepeat AnalysisCompression Force Test
Before each patient
Daily
WeeklyMonthly
Monthly
Semi-annuallySemi-annually
QC Tests Unique to SBBMinimum Testing Frequencies
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Zero Alignment Test(only on some units)
Localization Accuracy Test (in Air)
Phantom Image Quality TestHardcopy Output Quality(if hard copy is produced from digital data)
Visual Equipment CheckRepeat AnalysisCompression Force Test
An overview of the QC Tests Unique to SBB(Radiologic Technologist)
RT
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Zero Alignment Test
u Perform before each patientu Verify that zero coordinate is
accurateu Assures that stereotactic unit is not
improperly installed
B
RT
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Localization Accuracyu Closed loop system testu Position needle to a known
coordinateu Digitize position of needle tipu Targeting software calculates
position of needle tipu Coordinates should be identicalu ± 1.0 mm sphere
D
RT
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Phantom ImageQuality Evaluation
FiberDiameters
(mm)1.561.120.890.750.540.40
SpeckDiameters
(mm)0.540.400.320.240.16
Mass Diameters (mm) 2.00, 1.00, 0.75, 0.50, 0.25
D-102
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Phantom ImageQuality Evaluation
NuclearAssociates Digital
Mini Phantom
MammographyAccreditation
Phantom
W
RT
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Fibers
Specks
Masses
1.561.120.80.750.540.540.40.320.240.16
21
0.750.50.25
xx
0.930.740.540.54
x0.320.240.2x1
0.750.50.25
ACRAccreditation NA Digital
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Minimum PassingPhantom Image Scores
FibersSpecksMasses
ACR-MAP
Screen/film
4.03.03.0
AccreditationPhantom
Digital
5.04.03.5
Mini-Phantom
Digital
3.03.02.5
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Phantom Imaging: a common avoidablefailureu NAD Digital Mini Phantom
1st image (image quality)2nd image (TLD)
u Mammo Accreditation Phantom4 images for image quality5th image for TLD
u OK to window/level digital imagesu Use grid (or not) per clinical technique
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HardcopyOutput Qualityu Laser or multiformat camerau Evaluate SMPTE Test Pattern, if
availableu Record window width, levelu Produce hardcopyu Measure OD at 4 consistent
locationsu Record and monitor for consistency
M
RT
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Visual Checklist
u Use ACR checklist or equivalentu Lights, switches, motion, accessoriesu Customize for your
machine/roomu Documentation
(date, initials)
M
RT
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Repeat Analysisu Count repeated and rejected film by
category and tabulateu Include a log of images repeated, but
not discardedu Overall repeat rate should be < 5%u Document analysis and corrective
action - even if your repeat rate islow
Q
RT
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Compression Forceu Bathroom scale or
compression gaugeu Measure maximum
compression in manualand power modes
u The scale should read25-40 pounds inautomatic mode
u Documentation
S
RT
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Additional Technologist’sQC Tests (Screen-Film
only)TEST
Darkroom Cleanlinessprocessor QC
Screen CleanlinessViewboxes & Viewing
ConditionsFixer Retention Analysis
Screen-Film ContactDarkroom Fog
FREQUENCYDailyDaily
Weekly
WeeklyQuarterly
Semi-AnnuallySemi-Annually
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SBB Annual Medical Physics Surveyu SBB Unit Assembly Evaluationu Collimation Assessmentu Focal Spot Performance and System Limiting
Resolutionu kVp Accuracy and Reproducibilityu Beam Quality Assessment (HVL)u Automatic Exposure Control System
Performanceu Uniformity of Screen Speed or Digital Fieldu Breast ESE, AGD, AEC Reproducibilityu Image Quality Evaluation (phantom)u Artifact Evaluationu Localization AccuracyMP
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Assembly Evaluationu Free-standing unit is mechanically stable
u All moving parts move smoothly, withoutobstructions to motion
u All locks and detents work properly
u Image receptor holder is free from vibrations
u Image receptor is held securely by assembly inany orientation
MP
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Assembly Evaluationu Image receptor slides smoothly into holder
assembly
u Compressed breast thickness scale is accurateto ± 0.5 cm, reproducible to ± 2 mm
u Patient or operator is not exposed to sharp orrough edges or other hazards
u Operator technique charts are posted
u Operator protected by adequate radiationshielding
MP
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CollimationuDoes the x-ray beam exceed the image
receptor?
Note: X-rays beyond the digital imagereceptor will not be seen on the monitor
uDoes the biopsy window align with the imagefield of view?
MP
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Performance - SystemLimitingResolutionu Line Pair Test Patternu Use film to test x-ray
machineu Use CRT image to test
“system”u Technique, clinical kVpu Scoring the image
Lines distinct over 1/2 length
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kVp Accuracy -Reproducibility
u Verify that actual kVp’s are the same as the
indicated kVp’s
u Range of clinical kVp values
u Accuracy within 5%
u Reproducible CV < 0.02
MP
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Beam Quality (HVL)u Thickness of aluminum
to reduce radiationexposure by one-half
u Affects contrast anddose
u Used in dosecalculation
u minimum = kVp/100
MP
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AEC System Performanceu AEC available on some digital SBB unitsu Performance Capability
Record signal level asfunction of thicknessand technique
u Monitor exposure timeu Performance Capability
(4,6,8 cm)u Provide suggested
technique chart
MP
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Varying thicknesses ofbreast equivalent material
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Uniformity of ScreenSpeed or Digital Field
u Image a uniform phantomu Screen Film systems
Each cassette produces the sameoptical density under the sameconditions
u Digital SystemsDigital detector produces uniform signalvalues across the field of view
MP
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Phantom Image Qualityu Same procedure as
for technologistsu Medical Physicist
reviews scoringprocedure andchecks forconsistency
u Uses techniquefactors for dosedeterminationMP
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Breast Entrance Exposure,AGD
u Data per technique chartu Measure ESEu HVL determines DgNu AGD = ESE * DgNu AGD < 300 mradu Dose and Optical Density
MP
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Artifact EvaluationUnwanted irregularity not caused
by structures of interestCauses (Digital)
Digital Image ReceptorCauses (Screen-Film)
Lint, dust, static, filter,compression device, grid,BSD, screen, film,cassette, phantom
Common CausesUnwanted objects in x-ray beamMP
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Source of Artifacts (Film)
Direction of Film Feed
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Source of ArtifactsChange of orientation
Processor related
Either parallel orperpendicular todirection of travel
Plus or minus density
Rollers
Guide shoes
Replenishment stream
No change of orientation
X-ray tube
Filter
Compression device
BSD
Grid (stop motion)
Cassette
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Targeting Accuracyu Performed annually by technologist
under supervision of medical physicistu Position gel-type phantomu Image, target and sampleu Result: was the lesion collected?
MP
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QC Program Review
u Review procedures(ACR SBB-QC Manual)
u Review documentationu Answer questionsu Written recommendations
MP
For all Technologist QC Tests
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Role of the Surgeon inQuality Control
u Understand the importance of QC in SBBu Assures that personnel remain qualifiedu Support QC activities
Allow enough time for QCProvide for QC trainingPeriodically check that QC is done as required
u Confer with medical physicist annuallyu Assure that follow-up is done if the QC
program indicates corrective action is requiredu Accreditation
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Summary
uWhat is a SBB?u Purpose of ACR-SBBAPu Requirements for accreditationu Technologist’s QC Testsu Medical Physicists QC Tests