Redonyl® UltraSoft Chews(Ultra-micronized Palmitoylethanolamide [PEA])

Redonyl® UltraFeline(Ultra-micronized Palmitoylethanolamide [PEA])

PEA is a naturally-occurring skin lipid produced in response to tissue injury and stress. PEAlevels are 30 times higher in unhealthy skin.1

Mast cells are the target of PEA. In the presence of allergens, mast cells degranulate and release histamine and other inflammatory mediators, generating the signs typically associated with allergies.

PEA downregulates mast cell degranulation and inhibits the release of inflammatory mediators (such as histamine) from mast cells.2 These actions result in a more stable skin environment in allergic dogs and cats.

Allergens Enter the Skin...

Skinbecomespruritic(itchy).

Mast cells release histamineand other inflammatory mediators.

The pet begins to scratch, lick,and chew to relieve the itchiness.This can lead to secondaryinfections and other skin issues.

...Triggering the Immune System to Respond

An ultra-small ingredient that offers ultra-big support for skin health.

To order or schedule a lunch and learn, call your Dechra representative or call (866) 683-0660.

For Technical Support Contact Dechra Veterinary Products at: 866-933-2472, www.dechra-us.com, support@dechra.com.

Redonyl Ultra Soft Chews provide a concentrated source of PEA for your allergic patients. Redonyl Ultra is a first-in-class nutraceutical with ultra-micronized PEA. Concurrent use of Redonyl Ultra Soft Chews and topical therapiesfor the skin, including shampoos, mousse, conditioners, sprays, and wipes, can help maintain the health of your canine patients’ skin. For skin issues with wide ranging causes, a multimodal approach is often recommended. Add Redonyl Ultra Soft Chews to your current dermatology protocol for additional skinsupport.

Redonyl Ultra Soft Chews • PEA supports skin health in allergic dogs• Ultra-micronized PEA has increased absorption4,5 and effectiveness6 compared with other PEA sources• Hypoallergenic soft chew contains no wheat, beef or chicken (protein molecules

Optimized Dosing Chart

Dog – Pounds 100 mg 200 mg Frequency Months of SupplyLess than 7 ½ chew Every other day 16

7 – 14 ½ chew Once daily 815 – 24 1 chew Once daily 425 – 35 1 ½ chews Once daily 2.7

36 – 49 1 chew Once daily 450 – 73 1 ½ chews Once daily 2.7

74– 100 2 chews Once daily 2

In an 8-week study of 160 client- owned dogs, oral PEA-um was shown to be beneficial for skin health.3 75% of the clinicians rated the overall response to be “sufficient”, “good” or “excellent”. Tolerability in this study was good-to-excellent with only four dogs experiencing associated reversible side effects.

REFERENCES1. Abramo F et al. BMC Vet Res. 2014;10(1):21.2. Cerrato S et al. Vet Immunol Immunopathol. 2010;133(1): 9-15.3. Noli, C et al. Vet Dermatol. 2015;26(6):432-440.4. Kim MS et al. Chem Pharm Bull (Tokyo). 2010:58(2) :230-2335. Rasenack N, Muller BW. Pharm Dev Technol. 2004:9(1)1-13.6. Luvone T et al. Data on file (brevetto PCTWO2011/027373A1)

Redonyl® UltraFeline(Ultra-micronizedPalmitoylethanolamide [PEA])

Available in a 3.5 ounce powder form for your feline patients.• Palatable, flavorless, and odorless• Hypoallergenic• Contains no wheat, beef, chicken, or other flavoring

In a four-month double-blinded randomized controlled study of 57 client-owned cats, PEA-um was shown to have a significant effect on skin health. Owners also judged PEA-um to be superior to placebo in maintaining healthy skin. Tolerability was good, with only two cats experiencing non-serious side effects. The study authors concluded that PEA-um may be a valid option in the multimodal management of feline skin health.7

Redonyl® is a patented product by Innovet Italia S.r.l. Redonyl Ultra is protected by the following US patents: 6,548,550, US 8,470,373, and US 8,663,701. Dechra is a registered trademark of Dechra Pharmaceuticals PLC. © Dechra 02PG-RED50149-0420

REFERENCES7. Noli C et al: Vet. Dermatol 2019; 30: 387-e117.

Redonyl Ultra Feline Dosing Chart

Cat – Pounds # of Scoops Frequency

Monthsof

Supply9.0 lb or less 1 scoop Daily 2.49.1 lb or more 1.5 scoops Daily 1.6