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Share the Vision 2013 Directory of Faculty Presenters 1

SHARE THE VISION2013

Directory of Faculty PresentersOffice of

Technology

Management

04 Life Sciences, Devices04 RASHID BASHIR: BioMEMS and Biomedical

Nanotechnology: Lab on Chip to Building with Cells

04 JOHN KATZENELLENBOGEN: Unusual Actions of Estrogens and PET Imaging of Estrogen Receptor Activity in Breast Cancer

05 KEN SUSLICK: Colorimetric Sensor Arrays

06 JOHN ROGERS: Electronics That Dissolve In Your Body

07 RYAN BAILEY: Silicon Photonics: A Transformative Technology for Multiplexed Clinical Diagnostics

08 Computational Methods for Health08 KLAUS SCHULTEN: Computational

Microscopy for Health and Technology

09 OLGICA MILENKOVIC: Signal Processing in Computational Biology and Life Sciences

09 VICTOR JONGENEEL: Accelerating the Discovery of Human Genomic Variation

10 CATHERINE BLAKE: Using the Claim Framework to Synthesize Evidence and Accelerate Scientific Discovery

10 IAN BROOKS: INDICATOR: Integrating Common Data Sources for Community Health Monitoring

11 Life Sciences: Enabling Systems11 STEVE ZIMMERMAN: Drug Discovery -

Potential Therapeutics that Target RNA and DNA

11 FEDERICO ZUCKERMANN

12 MARTIN BURKE: A Small Molecule Synthesizer

13 WILLIAM METCALF: Genome-Enabled Discovery of Bioactive Natural Products

13 SATISH NAIR: Expanding Nature’s Enzyme Toolkit: Applications for New Antibiotics and Biofuels

14 SUA MYONG: Single Molecule Fluorescence Imaging of Biomolecules

14 RICHARD TAPPING: Therapeutic Targeting of Toll-like Receptors

15 MARTHA GILLETTE: Designer Microfluidic Environments for Cell & Tissue Research

16 Big Data, Networking & Security16 INDRANIL GUPTA: Fast Distributed Systems

for Big Data

16 VIKRAM ADVE: Trusting (Almost) Nothing: Making Modern Software More Secure

18 CHENGXIANG ZHAI: General Statistical Methods for Integration and Analysis of Opinionated Text Data

18 JOSEPH TORRELLAS: Extreme-Scale Computer Architecture: Energy Efficiency from the Ground Up

19 JAIWEI HAN: Mining Heterogeneous Social and Information Networks for Big Data Applications

19 Global Challenges19 STEPHEN LONG: Realizing Photosynthetic

Efficiency

20 JEFFREY MOORE: UIUC and the Energy Storage Hub

20 BRYAN WHITE: From Individualized Medicine to Precision Healthcare

21 CARL A. GUNTER: Six Research Challenges for the Security and Privacy of Health Information Technology

22 Advanced Materials & Engineering22 SOON-JO CHUNG: Revolutionary Aerial

Drones: Development of Robotic Falcons to Prevent Airport Bird Strikes

23 LYNFORD GODDARD: In-situ Optical Inspection and Metrology for Advanced Manufacturing Processes

24 MILTON FENG: Nano Transistor Laser for Energy Efficient Optical Interconnect

25 JOHN DALLESASSE: The TIQCL: A Novel Mid-IR Emitter for Chemical Sensing and Biological Imaging

25 XIULING LI: Shrinking Inductors, Transformers, and More

26 WILLIAM P. KING: Digital Manufacturing

26 PAUL BRAUN: In vivo continuous glucose monitoring with photonic crystal sensors

27 ANDREW ALLEYNE: Simulation and Analysis for Dynamical Energy Systems

Table of Contents


UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNThe University of Illinois at Urbana-Champaign is a world-class research

institution, boasting a respected faculty, high national rankings, and state-of-the-art facilities. The University’s accomplishments include 22 Nobel Laureates among its faculty and alumni and revolutionary innovations such as the Web browser, new plant varieties, and the discovery of a third form of life.

Illinois’ entrepreneurial momentum is high. The Association of University Research Parks named the University’s technology park as the 2011 Outstanding Research Park, recognizing its excellence in transitioning technology from the laboratory to commercially viable businesses. The Research Park, currently home to more than 90 companies, was also named by one of Inc.’s Three College-Town Incubators Worth Watching in 2013.

Additionally, 12 start-up companies were formed out of the University during 2011—a record high for Illinois—for a total of 35 start-up companies over the past five years.

The research and innovation that comes out of Illinois has a profound impact on human issues and the creation of businesses, jobs, and economic well-being.

OFFICE OF THE VICE PRESIDENT FOR RESEARCHThe University of Illinois has a unique and comprehensive system to support entrepreneurship and economic

development. It has remarkable research, robust commercialization and technology transfer efforts, a start-up incubator and support services, and an early stage technology investment firm. The Office of the Vice President for Research (including the Offices of Technology Management in Urbana and Chicago, IllinoisVENTURES, and the Research Park) is committed to developing deep and meaningful relationships between Illinois’ innovative faculty and industry, government, and academic partners.

SHARE THE VISION 2013 TECHNOLOGY SHOWCASEInnovation is one of the foundations of a research university. Translating that

innovation into societal impact is the mark of an exceptional research university like Illinois.

We are proud to present the work of 35 Illinois faculty, whose cutting-edge research is making a difference in today’s world.

Our faculty presenters have received national and international recognition for their work through numerous fellowships, research awards, and prestigious publications.

We invite you to get to know their research programs and hope that this event helps facilitate productive and lasting relationships.

OFFICE OF TECHNOLOGY MANAGEMENTThe Office of Technology Management’s mission is to encourage innovation, enhance research, and facilitate

economic development through the transfer of intellectual property.

In its primary area of responsibility, the office provides in-house technology protection and commercialization services to transfer intellectual property created on the Urbana campus into practical use to benefit the public as quickly and effectively as possible.

SHARE THE VISIONOCTOBER 10¬11, 2013

University of Illinois at Urbana-Champaign • Office of Technology Management4

bacterial detection and identification for the industrial microbiological markets. www.biovitesse.com

Daktari Diagnostics, Inc. delivers critical diagnostic test results to clinicians and patients across the globe. The first product is planned to be a point-of-care HIV detection system for counting CD4+ cells from whole blood. www.daktaridx.com

TalkBioMEMS and Biomedical Nanotechnology: Lab on Chip to Building with CellsBiomedical applications of micro and nanotechnology hold tremendous promise in diagnostics, therapeutics, and tissue engineering. Lab on chip devices can be used for the rapid and sensitive detection of biological entities, including cells, bacteria, proteins, and DNA. These microfluidic devices can provide for the sensitive and selective detection of CD4+ T cells for detection of HIV/AIDs for global health at point of care. Significant opportunities exist for rapid point-of-care detection of nucleic acid molecules from bacterial or viral agents of infection, for food borne pathogens.

To date, many of such devices or systems are constructed with silicon, PDMS, or other polymers. However, the fabrication of milli and micro scale systems and machines, with living cells as the building blocks, can represent a new frontier for BioMEMS. Tremendous opportunities exist in the 3-dimensonional bio-fabrication of such cell-based bioactuators, autonomous biological micro robots, and cellular machines

for a wide range of applications. This talk will present an overview of our efforts in these exciting areas at the intersection of biology and engineering at the micro and nanoscale.

JOHN KATZENELLENBOGENChemistry, Beckman Institute for Advanced Science and Technology

ResearchThe molecular details

of action of steroid hormones using chemical and spectroscopic tools and molecular biology to understand how these interesting proteins work and to develop novel medical diagnostic procedures.

Honors• Leading Edge in Basic Science Award from the

Society of Toxicology (SOT), 2009

• Gustavus John Esselen Award for Chemistry in the Public Interest, 2008

• American Chemical Society (ACS) E. B. Hershberg Award for Important Discoveries in Medicinally Active Products, 2007

Start-up CompanyRadius Health, Inc. is a biopharmaceutical company focused on developing new therapeutics for the treatment of osteoporosis and other women’s health conditions. www.radiuspharm.com

RASHID BASHIRElectrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, Institute for Genomic Biology

ResearchThe interface of biology and engineering from molecular to tissue scale, and the application of semiconductor fabrication to biology, all applied to solve biomedical problems

Honors• Director, Micro and Nanotechnology

Laboratory

• Fellow, American Institute of Medical and Biological Engineering (AIMBE), 2009

• Fellow, Institute of Electrical and Electronics Engineers (IEEE), 2009

Start-up CompanyBioVitesse, Inc. develops, manufactures, and markets automated, in-process quality control monitoring systems and solutions for rapid

Life Sciences: Devices


Start-up CompaniesiSense, LLC and its spin-off Metabolomx are located in Mountain View, CA and are commercializing Suslick’s optoelectronic nose. These companies were co-founded by Dr. Suslick and Dr. Paul A. Rhodes, a serial entrepreneur in Silicon Valley. Their primary goal is the diagnosis of disease by the signature pattern of metabolic biomarkers in breath and the development of biomedical applications of artificial olfaction. This includes rapid diagnosis of bacterial infections and breath diagnosis of lung cancer and pulmonary infections. www.metabolomx.com

PET, and various PET-based hormone challenge paradigms have been developed to query whether the tumor ER remains functional as a mediator of endocrine therapies. In both cases, we have obtained much higher predictive values for endocrine therapy success than is achieved with standard ER assays.

KEN SUSLICKChemistry, Beckman Institute for Advanced Science and Technology, Institute for Genomic Biology

ResearchThe chemical effects of high intensity ultrasound, which includes nano-materials synthesis and sonoluminescence, and chemical sensing, specifically artificial olfaction and handheld devices for the detection of toxic gases, explosives, and biomarkers based on colorimetric sensor array technology.

Honors• Fellow, American Chemical Society

(ACS), 2010

• Fellow, Materials Research Society (MRS), 2009

• Royal Society of Chemistry, Sir George Stokes Medal, 2008

• American Chemical Society (ACS) Senior Cope Scholar Award, 2004

TalkUnusual Actions of Estrogens and PET Imaging of Estrogen Receptor Activity in Breast CancerWhile estrogens are normally thought of as sex hormones that regulate reproduction and drive some breast cancers, they have many other, mostly desirable effects, including protection of the brain and cardiovascular system from injury. We have succeeded in designing estrogens that are essentially devoid of reproductive and breast cancer stimulatory effects, yet retain good brain and cardiovascular protective activity. This selectivity can be achieved by distinct, mechanistically novel approaches: (1) selective targeting of the different estrogen receptor subtypes, ERα and ERβ, (2) restricting the locus of estrogen action within the cell, and (3) controlling the duration of binding to the ERs. With further development, each of these mechanisms has the potential of underlying novel classes of pharmaceutical agents.

Endocrine therapies, such as the use of antiestrogens (e.g., tamoxifen) or estrogen biosynthesis inhibitors (aromatase inhibitors), can be effective in treating some breast cancers, but only about 1/3 of the patients respond. Even among patients whose breast cancers are considered to be ER+, only half show a favorable response to these endocrine therapies; response in ER- cancers is very rare. We have developed PET (positron emission tomographic) imaging agents and protocols to select those ER+ patients most likely to benefit from endocrine therapies. Fluorine-18 labeled estradiol (FES) has been demonstrated to provide a more accurate measure of breast tumor ER levels by

A disposable, colorimetric sensor array for the

detection of toxic gases and volatile biomarkers.


Honors• Director, Materials Research Laboratory

• Recipient of the 2011 Lemelson-MIT Prize for innovation.

• Selected to Nature’s 10, a collection of 10 scientists who mattered in 2011

• MacArthur Fellowship, 2009

Start-up CompaniesSemprius is commercializing low cost, high performance concentrator photovoltaic modules for utility scale power generation. The company’s unique micro-transfer printing technology enables CPV modules with world-record efficiencies, in forms that offer excellent reliability and straightforward paths to high-volume manufacturing. www.semprius.com

MC10 is commercializing classes of electronics that can fold, twist, and conform to three dimensional surfaces in ways that are not possible with technologies that exist today. Applications range from wearable sports monitors to advanced surgical tools, curved focal plane cameras, structural sensors and others. www.mc10.com

TalkElectronics That Dissolve In Your Body A characteristic feature of modern silicon integrated circuit technology is its ability to operate in a stable, reliable fashion, almost indefinitely for practical purposes. Recent work

collaboration with the Cleveland Clinic, our technology has also been applied successfully to breath diagnosis of lung cancer, a new approach to non-invasive screening of disease.

JOHN ROGERSMaterials Science and Engineering, Beckman Institute for Advanced Science and Technology

ResearchUnconventional

semiconductor materials, and their use in classes of devices that cannot be achieved using established, wafer-based technologies. The focus ranges from materials to mechanical engineering, manufacturing science, device design and system integration. Outcomes of recent work include the first hemispherical digital imagers, epidermal electronic devices and instrumented catheter balloons.

TalkColorimetric Sensor ArraysWe have developed an entirely new class of lightweight chemical identification systems based on disposable colorimetric sensor arrays: essentially a digital, multidimensional extension of litmus paper, creating a cross-responsive sensor array. Although no single chemically responsive pigment is specific for any one analyte, the pattern of color change for the array proves to be a unique molecular fingerprint.

For the chemical workplace, we have created the chemistry equivalent of a radiation badge for personal dosimetry of toxic gas exposure, with extremely high sensitivity (below PEL levels) for the detection of a wide range of toxic industrial chemicals (TICs) even at ppb levels. Broad applications to industrial QC/QA have also been demonstrated for a wide range of food and beverages.

The technology is also particularly suitable for detecting many of the most odiferous compounds produced by bacteria. We are able to distinguish bacterial growth even at very low levels of detection and can easily identify one pathogenic bacterium from another. In

Silicon electronics, in a non-coplanar mesh layout,

wrapped on the surface of a golfball.

Curved electronic eye that exploits advances

in stretchable electronics.


fabrication, our group has developed a new biomolecular analysis platform based upon silicon photonic microring resonators.

This detection strategy leverages well validated semiconductor fabrication, laser sources from optical telecommunications, and conventional microarraying tools to create highly multiplexed and robust biosensor arrays that are extraordinarily sensitive to biomolecular binding events at the sensor surface.

In this talk, I will describe our efforts to develop this emerging platform in the context of creating multiplexed detection solutions for a range of both clinical diagnostic and fundamental bioanalytical challenges.

Top Innovators under 35, 2012

• Alfred P. Sloan Foundation Research Fellow, 2011

• NIH Director’s New Innovator Award, National Institutes of Health, 2007

Start-up CompaniesGenalyte is a next generation clinical and life science company specializing in instrumentation and multiplex assays for biomarker and protein detection. www.genalyte.com

TalkSilicon Photonics: A Transformative Technology for Multiplexed Clinical DiagnosticsThe concept of personalized medicine is predicated on an ability to comprehend a patient’s disease state in a highly informed manner that ideally illuminates an effective, molecularly-targeted treatment strategy. A growing body of evidence suggests that the simultaneous measurement of many unique biomolecular signatures from a single clinically relevant sample would be incredibly enabling in achieving such an informative diagnosis.

Unfortunately, this is an analytical feat that currently is not possible using established methods, thereby limiting the implementation of informative molecular diagnostic and theragnostic strategies in the clinical treatment of disease. In response to this and other bioanalytical challenges that simultaneously require high sensitivity, high level multiplexing capability, and scalable and cost effective sensor

demonstrates that carefully selected sets of materials and device designs enable a class of silicon electronics that has the opposite behavior -- it physically disappears in water or biofluids in a controlled manner at programmed times. This talk summarizes the essential elements of this technology, ranging from the materials and manufacturing methods to components and systems with radio frequency operation to options in power supply to schemes for externally ‘triggering’ the onset of dissolution. Non-antibiotic bacteriocidal ‘appliques’ for control of surgical site infections represent one of many application areas in biomedicine.

RYAN BAILEYChemistry, Beckman Institute for Advanced Science and Technology, Institute for Genomic Biology

ResearchNew bioanalytical tools to understand the onset and progression of disease. Areas of particular interest are cancer diagnostics and theranostics, immunology, and epigenetics.

Honors• Arthur F. Findeis Award for Achievements

by a Young Analytical Scientist, Division of Analytical Chemistry, American Chemical Society (2013)

• Named to MIT Technology Review’s TR35: 35 Array of sensor chips for multiplexed diagnostics

fabricated via commercial semiconductor processes.


capsid; this structure is already being used to help understand how HIV-inhibiting drugs work on the capsid, thus offering unprecedented opportunities for developing pharmacological interventions. Our Center also studies, at the most detailed level possible, the chemical processes involved in second-generation biofuels production and in photosynthesis to help guide new means of extracting chemical energy from renewable resources. As a leader in applying the latest petascale computing technology to science, we will soon be able to generate atomic-level views of entire living cells, opening a treasure chest of data for biotechnology, pharmacology and medicine.

This lecture will present practical applications of computational microscopy covering nanosensor development, protein design, antibiotics, antiviral drugs, photosynthesis, and novel enzymes for producing biofuels from agricultural waste.

using computational methods, offering insights into new solutions to mankind’s health and energy needs. Engineers and scientists at our NIH Center for Macromolecular Modeling and Bioinformatics have worked over the last two decades to combine the most advanced computer technology and the best biomedical science to develop a suite of computer programs that today serve over 300,000 registered users in many fields of biology and medicine. These programs, which can be used on every kind of computer from personal laptops to the massive supercomputers at all major computer centers in the world, utilize the most highly resolved microscopies (X-ray, electron beams) to provide chemically detailed views of systems such as healthy and diseased cells and of whole viruses.

Our Center recently published the first complete atomic resolution structure of the full HIV

KLAUS SCHULTENPhysics, Beckman Institute for Advanced Science and Technology

ResearchThe structure, dynamics, and function of

biomolecular systems, including large protein complexes, virus capsids and bioenergetic membranes as well as the quantum biology of photosynthesis, vision, and animal navigation.

Honors• Director of the NIH Center for

Macromolecular Modeling and Bioinformatics and co-director of the NSF-funded Center for the Physics of Living Cells

• Swanlund Endowed Chair

• Professor, Center for Advanced Studies

TalkComputational Microscopy for Health and TechnologyIt is today becoming possible to view and study biological systems on the cellular scale

Computational Methods for Health

Institute for Genomic Biology. Photo courtesy of UI Public Affairs


• Director, Vital-IT HPC facility, Swiss Institute of Bioinformatics, 2003-2007

Start-upsAccelerated Genomics was founded in July 2013 to commercialize Genome Sequence Alignment (GSA) technology developed by Reza Farivar in collaboration with Roy Campbell (Computer Science) and Victor Jongeneel (IGB). The new GSA technology allows the alignment of short sequencing reads to a reference genome under conditions where the alignment contains both mismatches and short insertions or deletions, while improving on the performance of existing alignment algorithms.

TalkAccelerating the Discovery of Human Genomic VariationThe development of individualized medicine relies on our technical ability to document individual variations in genome sequence from very large numbers of short reads generated by current sequencing technologies. The difficulty in achieving this is compounded by relatively high error rates in the reads (in the order of 0.5% per nucleotide), co-existence of two haplotypes in each individual, and structural and copy number variations. Furthermore, the computational resources required to analyze the data from even a single individual are considerable.

The GSA technology developed by Accelerated Genomics addresses two specific bottlenecks. First of all, the accuracy and flexibility of the alignment algorithm that match the reads to the

end user, my group has developed a number of theoretic and practical solutions for biological data mining and pattern analysis. These include the first prototype of a compressive sensing DNA microarray, compressive genotyping algorithms using a new group testing framework, as well as the first parallel implementation of a metagenomic assembler and metagenomic compression algorithm. In the talk, I will describe our recent results on metagenome compression and our undergoing efforts in building the first rewritable DNA-based storage system.

VICTOR JONGENEEL

Bioengineering, Institute for Genomic Biology, National Center for Supercomputing Applications

ResearchCombining the fields of information retrieval, natural language processing, machine learning, data mining, and bioinformatics. The emphasis is on managing and exploiting large amounts of text information and developing effective information retrieval models.

Honors• Director, High-Performance Biological

Computing, University of Illinois

• Vice-President for Research, The Cyprus Institute, 2007-2009

OLGICA MILENKOVICElectrical and Computer Engineering

ResearchDeveloping new approaches for studying

problems in bioinformatics and bioengineering using coding and information theory. In particular, fundamental questions pertaining to design methodologies for DNA microarrays with error- and quality-control features and DNA microarrays that utilize compressed sensing principles.

Honors• Top-three Paper Award, WCMB

(Germany), 2008

• NSF Career Award, 2007

• DARPA Young Faculty Award, 2007

TalkSignal Processing in Computational Biology and Life SciencesThe massive amount of data produced by next generation high throughput DNA sequencing systems, tandem mass spectrometers and RNA-seq technologies calls for efficient, accurate and, often, highly complex data processing, data analysis, and algorithm development. In order to speed up the data acquisition cost, to reduce the storage cost and to make data analysis transparent to the


medicine and risk assessment process used in toxicology to demonstrate how the Claim Framework can augment existing human synthesis processes and accelerate discovery.

IAN BROOKSLibrary and Information Science, National Center for Supercomputing Applications

ResearchDeveloping software systems for biomedical data management and analysis for biomedical communities. Creating cyber-environments for infectious disease surveillance, modeling and response; endemic disease control; patient safety; and translational research.

Honors• Director, Health Sciences Group, National

Center for Supercomputing Applications

• Fellow, Community Informatics Institute

• Member of the Centers for Disease Control’s High Performance Computing External Advisory Committee

TalkINDICATOR: Integrating Common Data Sources for Community Health MonitoringBiosurveillance has been a largely centralized activity focused on one or two narrowly defined data sources such as hospital emergency

TalkUsing the Claim Framework to Synthesize Evi-dence and Accelerate Scientific DiscoveryEvery year more than one million abstracts are added to MEDLINE, the primary source of biomedical literature. Although the number of articles exceeds our human processing capacity, the electronic availability of these texts affords automated solutions. One way to deal with information overload is to construct systems that better match a user’s query to a set of relevant articles; however, with so many relevant articles decision makers, physicians, and consumers alike need methods that summarize information from within a set of abstracts or full text articles.

Our research group has been developing natural language processing methods that automatically capture the results of a scientific article. At the core of this research is the Claim Framework, which captured more than 99% of the claims made in a sample of full-text articles from medicine and epidemiology. We have since applied the framework to toxicology and our early work on social science literature recently received an honorable mention. Part of our research explores systematic differences between the results reported in an abstract and the results reported in the full text of an article. Thus far, we have demonstrated that fewer than 8% of claims are made in the abstract, and that the processing time required for full text articles is about three times more than abstracts, due in part to the complexity of the sentence structure. This talk will draw examples from the meta-analysis processes used in evidence-based

reference genome impacts all of the downstream variant calling steps. Secondly, the alignment step is the most computationally demanding in the process. Our experience with implementing complex workflows for the processing of high-throughput human sequences and the generation of reliable variant calls enables us to integrate the new GSA algorithms into a clinically useful framework.

CATHERINE BLAKELibrary and Information Science

ResearchDeveloping natural language processing

methods that accelerate scientific discovery by finding transitive connections both within and between scientific disciplines automatically. This work is consistent with the Socio-technical Data Analytics (SODA) group that focuses on both the social and technical aspects of data analytics.

Honors• Associate Director of the Center for

Informatics Research in Science and Scholarship (CIRSS)

• Faculty Fellowship, Environmental Change Institute, UIUC, 2010-2011

• John Wiley & Sons Best Paper Award, Journal of the American Society for Information Science and Technology, 2007


TalkDrug Discovery - Potential Therapeutics that Target RNA and DNAAn unstable CTG triplet repeat in the DMPK gene on chromosome 19 is generally acknowledged to cause myotonic dystrophy type 1, the most common form of muscular dystrophy. This talk will present the literature background on how CUG-containing RNA transcripts directly lead to the symptoms of this incurable disease. By targeting this RNA sequence with cell permeable agents, we are working toward developing a therapeutic agent to treat this progressive disease. The rational design and development of this RNA-targeted class of agents will be described.

FEDERICO ZUCKERMANNVeterinary Medicine

ResearchPorcine-derived macrophage cell line, branded ZMAC, as

a homologous (native species) host cell for porcine virus vaccines. The ZMAC cell line has already been proven to efficiently replicate porcine reproductive and respiratory syndrome (PRRS) virus.

Honors• Pfizer Animal Health Award for Research

Excellence, 2004

STEVE ZIMMERMANChemistry

ResearchDevelopment and application of molecular recognition processes

in the areas of drug delivery, chemical sensors, medical diagnostics, anti-gene therapy, and novel materials. The research targets design, synthesis, and study of organic compounds that can (1) act as synthetic antibodies to bind any target molecule, as well as signaling its presence, (2) bind to predefined sequences of DNA and RNA with very high affinity, (3) self-assemble into large, nanoscopic structures, and (4) act as supramolecular polymers.

Honors• Fellow, American Chemical Society

(ACS), 2009

• Fellow, American Association for the Advancement of Science (AAAS), 1998

• Arthur C. Cope Scholar Award, American Chemical Society (ACS), 1997

departments. Data has tended to flow in one direction, from the healthcare facilities providing data to state and national public health authorities with delays in results being communicated back to the data providers. In contrast, the community driven INDICATOR health monitoring system combines many sources of data to develop a picture of the health of a community—human, animal, and environmental—with immediate feedback on unusual events being sent to the data providers.

These data sources include school absenteeism, social media, veterinary clinics, and weather in addition to the more traditional emergency departments and convenient care clinics. This talk will describe the current state of the system with examples of how it has been used to change public health policy since first going into production in 2008. It will also discuss the recent redesign, ongoing expansion, and future plans.

Life Sciences: Enabling Systems


The laboratory of Martin Burke

and oligosaccharides (the three other major classes of biologically active molecules) are now all readily prepared via systematic, building block-based approaches that have been fully automated. The widespread impact of these advances has been profound. To promote a similar transformation with small molecules and thereby enable their extraordinary functional potential to be maximally harnessed, my group has developed a powerful and fully automated new platform for small molecule synthesis that employs a single reaction iteratively to rapidly and precisely assemble “MIDA boronate” building blocks having all of the required structural elements pre-installed. More than 140 of our MIDA boronates are already commercially-available, and these building blocks are being widely utilized to speed the discovery of new medicines by major pharmaceutical companies throughout the U.S., Europe, India, and Asia, including applications on both the discovery and process scales.

This work has been extensively highlighted in both the scientific and mainstream media, and is supported by an extensive IP portfolio. Ultimately, this powerful platform stands to dramatically accelerate the discovery of new medicines, probes, diagnostics, and materials, and ultimately bring the power of organic synthesis to non-specialists. It thus also stands to have a profound and pervasive impact on many areas of research and development. A new company is currently being formed to commercialize this technology.

LicensesProfessor Burke developed a class of protected boronates (MIDA Boronates) that has been licensed to Sigma-Aldrich, Allychem Co., and BoroPharm.

TalkA Small Molecule SynthesizerSmall molecules (pharmaceuticals, natural products, and organic materials) represent one of the most important molecular feedstocks for the advancement of medicine, science, and engineering. Highly trained specialists have traditionally prepared such compounds in the laboratory via the development of a unique pathway for each type of targeted structure. In stark contrast, peptides, oligonucleotides,

• Garner Awards Research Excellence Award, 2003

• Dr. Norman and Helen Levine Award, 2000

Start-upsAptimmune Biologics, Inc. specializes in the development and application of prophylactic measures against viral diseases of swine. The company’s current focus is effective prophylaxis against Porcine Reproductive and Respiratory Syndrome (PRRS) virus.

Aptimmune utilizes novel technologies to create effective vaccines against PRRSV such as the proprietary pig alveolar macrophage cell line ZMAC. www.aptimmune.com

MARTIN BURKEChemistry

ResearchSynthesis and study of small molecules with the capacity to perform protein-like functions;

Iterative Cross-Coupling (ICC), towards a general strategy for complex small molecule synthesis; the total synthesis of Amphotericin B via ICC.

Honors• Arthur C. Cope Scholar Award, American

Chemical Society (ACS), 2011

• Howard Hughes Medical Institute Early Career Scientist, 2009


TalkExpanding Nature’s Enzyme Toolkit: Applications for New Antibiotics and BiofuelsThe decreasing cost and technology advances in low-cost whole genome DNA sequencing have resulted in the massive influx of data important for medicine and health. In addition, sequencing of bacterial genomes has also lead to the identification of new, unanticipated routes for the transformation of simple precursors (i.e. amino acids and other primary metabolites) into value-added products (antibiotics, precursors for ethanologenic biofuels, etc.). In bacteria, the ensemble of activities that are needed for such transformations are often clustered and their functions are coordinated. Rational manipulation of one or more of the genes within a cluster

reduced or eliminated their natural product screening programs. This is not because new metabolites cannot be found, but rather because current screening methods are producing dramatically declining numbers of promising new candidates. To face this dilemma, new methods for high-throughput screening and identification of useful microbial products are needed.

Moreover, it is becoming increasingly clear that academic research will need to play a significant role in this search. Fortunately, recent innovations in small molecule detection and rapid, inexpensive DNA sequencing provide us the means to develop new screening approaches applicable to microbes on a large scale. Over the past two years we have employed this strategy to discover numerous novel antibiotics. Further, we are confident that the approach can be extended to rapidly discover tens of thousands of microbial natural products, many of which are likely to have useful pharmaceutical properties.

SATISH NAIRBiochemistry, Institute for Genomic Biology

ResearchPhysical chemical methods, in combination with biochemistry and

microbiology, to understand the molecular basis for enzymatic transformations. The focus of this approach is to derive high-value small products (i.e. antibiotics, and biofuels) by manipulating existing natural pathways.

WILLIAM METCALFMicrobiology, Institute for Genomic Biology

ResearchThe elucidation of the genes

and metabolic pathways involved in the biosynthesis of phosphonic acid antibiotics and exploring the molecular diversity of the natural products comprising this unusual class of bioactive compounds.

Honors• Appointed to the G. William Arends

Professorship in Life Sciences, 2013

• Fellow, American Academy of Microbiology (AAM), 2010

TalkGenome-Enabled Discovery of Bioactive Natural ProductsMicrobially produced natural products, or secondary metabolites, encompass an astounding array of small molecules with useful, and often medically relevant, properties. Approximately 75% of the currently used antibiotics are derived from these microbial products, while nearly 60% of anti-cancer drugs find a similar origin. While many powerful and effective drugs have been discovered in the past sixty years, a pressing need for the development of new therapeutic agents remains. Ironically, at a time of great need, many pharmaceutical companies have

Cyanobacterial symbionts use two proteases to

generate an anticancer compound from ribosomally

encoded peptide precursors.


RICHARD TAPPINGMolecular and Cellular Biology, Institute for Genomic Biology

ResearchInvestigating

mechanisms by which the human body senses infection, specifically, through a group of cell surface molecules known as Toll-like receptors that directly recognize specific structural components of viral, microbial, and fungal origin.

Honors• Scientific Advisor, International Endotoxin and

Innate Immunity Society, 2010-2012

• Keynote Speaker, Japanese Endotoxin and Innate Immunity Society Annual Meeting, 2010

• Advisor of the Year Award, Medical Scholars Program, 2008

LicensesMonoclonal antibodies for the detection of TLR10 licensed to BioLegend, eBioscience, Imgenex and Hycult Biotech

TalkTherapeutic Targeting of Toll-like ReceptorsToll-like receptors (TLRs) are central elements of the innate immune system that provide a first line of immune defense against infectious agents. Following direct recognition of bacterial,

• American Cancer Society Research Scholar Award, 2011

TalkSingle Molecule Fluorescence Imaging of BiomoleculesMolecular imaging techniques are critical for scientific research as well as biomedical applications. In particular, single molecule imaging techniques continue to emerge as the promising future technology for the high spatial and temporal resolutions they provide. Well known single molecule techniques include the Pacific Biosciences and Illumina DNA sequencing, nanostring (nCounter) used for mRNA profiling and super resolution cell imaging including STORM (Stochastic optical reconstruction microscopy) and PALM (Photoactivated localization microscope). I will talk about some of our research that showcases how single molecule fluorescence imaging enables one to gain insight about molecular mechanisms involved in DNA metabolism that lead to cancers.

can result in the production of novel products. Likewise, these new activities can be utilized in an “assembly line” fashion to devise new routes for production of value-added products.

Our group utilizes both of these approaches, using high-resolution structural data to manipulate and/or tweak the function of individual enzymes in a pathway, to rewire natural biosynthetic pathways to produce molecules not commonly found in nature. The focus of the talk will be centered on a “toolkit” approach for the production of microbially produced alkanes from fatty acid biosynthetic pathways, and a “tweaking” approach to derive new families of antibiotics based on the vancomycin scaffold.

SUA MYONGBioengineering, Institute for Genomic Biology

ResearchSingle molecule fluorescence assays as

well as high resolution cell imaging techniques to investigate DNA damage repair and genome integrity, microRNA processing and, virus infection and antiviral signaling.

Honors• Human Frontier Science Program Research

Award, 2012

• NIH Director’s New Innovator Award, 2012Single-molecule fluoresence to detect viral RNA

in cells.


information transfer. This environment is especially inhospitable for understanding the brain. Insights are needed from the microscale, mapping molecular pathways that drive responses to chemical signals, to the macroscale of the network. How can we probe emerging functionality at the sub-cellular level of communication between individual neurons, neuron-glial support cells, and networks?

New approaches are essential for advancing neuronal repair, both structurally and functionally, as well as developing effective treatments for debilitating disorders, such as Alzheimer’s disease, diabetic neuropathies, and paralysis. We present a new approach using fabricated designer environments that

MARTHA GILLETTEMolecular and Cellular Biology, Beckman Institute for Advanced Science and Technology, Institute for Genomic Biology

ResearchUnderstanding substrates of human behavioral disorders and neural disease. Particular areas of strength and interest include cellular neuroscience and imaging, neural plasticity, neuronal signaling and development, and microfluidic environments.

Honors• Center for Advanced Study Professor, 2009

• Women in Neuroscience Mika Salpeter Lifetime Achievement Award, 2004


TalkDesigner Microfluidic Environments for Cell & Tissue ResearchConventionally, cells have been studied as monoculture populations within plastic culture dishes. Analyses are averages of the population. This limits possibilities for high resolution spatial and temporal analysis of signals and

fungal or viral components TLRs activate intracellular signals that not only induce inflammatory processes but also provide a critical link between the innate and adaptive arms of the immune response. Despite tens of thousands of research publications on TLRs, the biologic function of TLR10 has remained unknown. This gap in our knowledge reflects a lack of identifiable ligands and signaling responses for TLR10 which is compounded by the fact that TLR10 is a disrupted pseudogene in mice.

In this talk I will describe the development of monoclonal antibodies against TLR10, some of which have been identified as agonists toward this receptor. Antibody-based studies, as well as newly developed TLR10 transgenic mouse models, show that TLR10 is expressed in the B cell lineage where it acts not as a stimulator, but as a suppressor or regulator of B lymphocyte activation processes including proliferation, cytokine production, antibody release and antibody class-switching. These findings identify agonistic anti-TLR10 antibodies as potential therapeutics for the treatment of diseases driven by dysregulated B cell activation including lupus and certain B cell lymphomas.

A single hippocampal neuron visualized by scanning

electron microscopy, with microfluidic device inset.


Big Data, Networking, and Security

VIKRAM ADVEComputer Science, Information Trust Institute

ResearchDeveloping and using compiler technologies

to improve the performance, reliability, and security of computer systems. Current research includes automated techniques to diagnose software failures; security solutions to minimize the need for applications to trust their underlying software platforms; and approaches to improving the programmability of parallel computing systems. An outcome of previous research -- the LLVM Compiler Infrastructure -- is widely used in industry today, ranging from smartphones (iOS and Android) to GPU computing (OpenCL and CUDA) to supercomputers (Cray, including Illinois’s Blue Waters) to data centers (some major Google products and internal tools).

Honors• ACM Software System Award for co-devel-

oping LLVM, 2012

• Audience Choice Paper Award, ACM Symposium on Operating Systems Principles, 2007

• Best Paper Award, ACM SIGPLAN Conference on Programming Language Design and Implementation, 2005

Honors• Center for Advanced Studies (CAS)

Fellowship/Beckman Fellowship, 2009-2010

• Junior Xerox Award for Faculty Research, UIUC, 2008

• NSF CAREER Award, 2005

TalkFast Distributed Systems for Big DataToday’s big data workloads range from graph processing to web indexing to machine learning, and involve data ranging from Gigabytes to Yottabytes. Today there is tremendous activity in industry around building scalable, robust and responsive software for storing and processing such big data in datacenters. For instance, the NoSQL storage market is expected to earn $14 B over the next 5 years, while the Hadoop market is expected to cross an annual revenue of $20 B by 2018. Other sectors such as processing of large-scale graphs are just getting started. This talk will outline my group’s ongoing and recent work in these areas. Topics range from making Hadoop adapt to real-time workloads, making NoSQL systems more available and consistent, storing graphs more efficiently, and making graph processing systems faster than state of the art by orders of magnitude. This work is supported by the Air Force and NSF, and involves collaborations with companies such as Yahoo! and HP Labs.

enable exquisite chemical and physical control and manipulation while integrating fixed or dynamic imaging.

Our approach uses microfluidic devices ( µFD) and focuses on controlling the microenvironment to study single neurons and their sub-regions within cultures of as few as 20. We will present our recent progress from key applications (chemical signals, emergent properties, network signal processing) that we envision will enable discovery and testing of new therapies for neurodegenerative disorders, neural regeneration, and recovery of damaged network function.

INDRANIL GUPTAComputer Science, Beckman Institute for Advanced Science and Technology

ResearchBuilding scalable

distributed systems for storing and processing today’s big data.


administrators who can compromise that trust. At the lowest level, between operating systems and hardware, we can carefully control all software-hardware interactions with no design changes to commodity operating systems, and with very minor porting effort. At the application level, we give programs the ability to compute and communicate securely and in secrecy, even if the operating system itself is compromised or hostile. At the network level, we give distributed applications the ability to communicate and share information securely and in secrecy.

Moreover, computer vendors, cellphone vendors, or data center operators can provide guarantees about the security of these solutions by combining them with trusted hardware primitives for remote attestation and key management, which take away the need to trust system administrators or users who install and operate the computing platforms. By putting these capabilities together, sophisticated applications can be developed that are not just more secure than they are today, but come with certifiable guarantees that can enable many more institutions to trust third-party systems, from mobile devices to the cloud.

• C. W. Gear Outstanding Junior Faculty Award, Computer Science Department, University of Illinois, 2002

TalkTrusting (Almost) Nothing: Making Modern Software More SecureMany individuals today own mobile phones or tablets for personal use. Companies and governments want to allow people to use those devices for business applications, but cannot trust that business-critical data will not be stolen or tampered with. Data centers have become extremely successful for hosted consumer applications like Gmail and Flickr and social networks like Facebook and Twitter, but many companies will not trust these platforms for business-critical data and applications.

The common refrain in both cases is a lack of trust: institutions are unwilling to trust computing environments outside their immediate control. The Trusted Computing Group, an industry standard-setting body, has defined a few, albeit limited, hardware and software mechanisms to address these concerns, but the fundamental problem of having to trust too much external software and too many outsiders remains.

We are developing software tools and techniques that greatly reduce the system components that must be trusted by secure applications; the “openings” through which that trust can be breached; and, most importantly, the third-party programmers and system

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are very easy to program, reliable, and built out of commodity components.

Honors• Director, Center for Programmable Extreme-

Scale Computing

• Fellow, Association for Computing Machinery (ACM), 2010


TalkExtreme-Scale Computer Architecture: Energy Efficiency from the Ground UpAs we move to higher levels of transistor integration, it is clear that power and energy efficiency are the most formidable barriers.

With extreme-scale computing, we are designing computer systems that are 100x more energy-efficient than current ones. We target a chip built out of 1000 processor cores, which requires fundamentally rethinking the whole compute stack from the ground up for energy efficiency.

At the circuit layer, we operate at very low supply voltages, while handling on-chip variation of transistor properties with clustering, voltage-frequency islands, and techniques for tolerating voltage noise. Hierarchical voltage regulators are used to attain high energy efficiency. At the architecture level, we use streamlined cores, with novel techniques such as functional unit throttling and multiple supply voltage rails.

of general statistical text mining methods developed by the Text Information Management and Analysis (TIMAN) group that can help users integrate, summarize, and analyze scattered online opinions to obtain actionable knowledge for decision making. Specifically, I will first present approaches to integration of scattered opinions by aligning them to a well-structured article or relevant ontology.

Second, I will discuss several techniques for generating a concise opinion summary that can reveal the major sentiments and opinion points buried in large amounts of opinionated text data. Finally, I will present probabilistic general models for analyzing review data in depth to discover latent aspect ratings and relative weights placed by reviewers on different aspects. These methods are completely general and can thus help users integrate and analyze large amounts of online opinionated text data on any topic in any natural language, opening up many interesting novel applications in multiple domains such as business intelligence, health and medical informatics, and security.

JOSEPH TORRELLASComputer Science

ResearchNew processor, memory, and system technologies and organizations to

build novel computer architectures with the goal of designing high-performance computers that

CHENGXIANG ZHAIComputer Science, Institute for Genomic Biology

ResearchDeveloping general

techniques for building intelligent information systems to help users manage and exploit large amounts of text information. Combining the fields of information retrieval, natural language processing, machine learning, data mining, and biomedical and health informatics.

Honors• Association for Computing Machinery (ACM)

Distinguished Scientist, 2009

• Sloan Research Fellowship Award, 2008

• Presidential Early Career Award for Scientists and Engineers (PECASE), 2004

TalkGeneral Statistical Methods for Integration and Analysis of Opinionated Text DataOpinionated text data such as blogs, tweets, forum posts, product reviews and online comments are increasingly available on the Web. They are very useful sources for public opinions about virtually any topics. However, because the opinions are scattered and abundant, it is a significant challenge for users to collect all the opinions about a topic and digest them efficiently. In this talk, I will present a suite


and methodologies have been developed in our recent research on mining heterogeneous networks, which include (1) meta path-based similarity search, (2) rank-based clustering, (3) rank-based classification, and (4) meta path-based link/relationship prediction. We vision that mining heterogeneous information networks could be a key to big data mining and may impact the analysis of big data in multiple disciplines.

STEPHEN LONGPlant Biology and Crop Sciences, Institute for Genomic Biology

Research RIPE – Realizing Increased

Photosynthetic Efficiency a project funded through a $25 million Gates Foundation grant that has the potential to benefit farmers around the world by increasing productivity of staple food crops.

• Association for Computing Machinery (ACM) SIGKDD Innovation Award, 2004

• Fellow, Association for Computing Machinery (ACM), 2003

TalkMining Heterogeneous Social and Information Networks for Big Data ApplicationsPeople and informational objects are interconnected, forming gigantic, interconnected, integrated social and information networks. By structuring these data objects into multiple types, such networks become semi-structured heterogeneous social and information networks. Most real world applications that handle big data, including interconnected social media and social networks, medical information systems, online e-commerce systems, or database systems, can be structured into typed, heterogeneous social, and information networks. For example, in a medical care network, objects of multiple types, such as patients, doctors, diseases, medication, and links such as visits, diagnosis, and treatments are intertwined together, providing rich information and forming heterogeneous information networks. Effective analysis of large-scale heterogeneous social and information networks poses an interesting but critical challenge.

Our recent research shows that the semi-structured heterogeneous information network model leverages the rich semantics of typed nodes and links in a network and enables the discovery of surprisingly rich knowledge from interconnected data. A set of new principles

The energy consumed by on-chip memories is reduced with intelligent refresh. Several components of the chip such as the network are designed with dynamic techniques to reduce energy consumption at the expense of a lower resilience guardband. The architecture also has novel support for synchronization and communication, and for processing in memory.

Finally, an efficient runtime layer provides system knobs for expert programmers to control the architecture and attain exteme-scale energy efficiency.

JAIWEI HANComputer Science, Beckman Institute for Advanced Science and Technology

ResearchUncovering patterns

and knowledge in massive data sets through the integration and further development of methods in multiple disciplines, including statistics, machine learning, database systems, algorithms, information theory, web technology, spatiotemporal text, multimedia, and biological data analysis, and high performance computing.

Honors• Fellow, Institute of Electrical and Electronics

Engineers (IEEE), 2009

• Institute of Electrical and Electronics Engineers (IEEE) W. Wallace McDowell Award, 2009

Global Challenges


Honors• Marsh Award for Climate Change Research,

Council of the British Ecological Society, 2012

• Charles F. Kettering Award, American Society of Plant Biologists, 2012

• Invited Expert on Food Security, President’s Council of Advisors on Science Technology (P-CAST), 2011

• Fellow, American Society of Plant Biologists (ASPB), 2009

TalkRealizing Photosynthetic EfficiencyImproving the photosynthetic properties of key food crops can contribute to addressing the challenge of this century: food security. The UN Food and Agricultural Organization predicts that the world will need to increase staple crop yields 70% by 2050. The rapid increases that were achieved during the Green Revolution have slowed and will not meet this target. Increasing photosynthetic efficiency has not yet been addressed by conventional breeding methods, though it has the potential to increase yields and also increase the efficiency with which crops use water and nitrogen.

The University of Illinois at Urbana-Champaign is leading an effort, supported by a $25M grant from the Bill & Melinda Gates foundation, to apply recent advances in photosynthesis research and crop bioengineering, computer simulations of the

highly complex photosynthetic system and practical engineering to identify the best targets for improving photosynthesis efficiency and provide part of the yield jump the world needs to maintain food security.

JEFFREY MOOREChemistry, Beckman Institute for Advanced Science and Technology

ResearchLeading campus efforts under a multi-

institutional, 5-year, $120 million Department of Energy (DOE) grant to establish a new Batteries & Energy Storage Hub that will advance

next generation battery and energy storage technologies for electric and hybrid cars and the electricity grid.

Honors• Fellow, American Chemical Society (ACS), 2010

• Fellow, American Academy of Arts and Sciences, 2008

• Fellow, Royal Society of Chemistry, 2006


TalkUIUC and the Energy Storage HubIn December 2013, the DOE announced that the $25MM / yr. energy storage hub was awarded to Argonne for its proposal on the Joint Center for Energy Storage Research (JCESR). This talk will give an overview of JCESR and the scientific activities of the UIUC researchers who participate in the hub.

BRYAN WHITENutritional Sciences

ResearchIndividualized medicine is the promise of advances in computing, genetics, and

nanotechnology. Yet translating these advances into real-world applications will require strong collaboration between leading research and clinical partners.

The electric grid is projected to become unstable if

non-dispatchable renewable energy exceeds 20%

of the energy-generation capacity without energy

storage capabilities. One of JCESR’s goals is to

develop the science and technology for effective grid

storage. Image: Dorothy R Loudermilk


The University of Illinois and Mayo Clinic have formed a strategic alliance to promote a broad spectrum of collaborative research, the development of new technologies and clinical tools, and the design and implementation of novel education programs.

Honors• Director, Mayo Clinic/University of Illinois

Strategic Alliance for Technology-Based Healthcare

• Spitze Land-Grant Professorial Career Excellence Award, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, 2010

• Paul A. Funk Recognition Award, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, 2007

TalkFrom Individualized Medicine to Precision HealthcareThe Mayo-Illinois Alliance aims to blend the technical engineering expertise of UIUC with the clinical practice expertise of the Mayo Clinic to develop new technologies that will transform the practice of medicine. The Mayo-Illinois Alliance educational goals are to advance biomedical and health science education by using innovative educational programs to train next generation clinicians and biomedical scientists in a joint program between the Mayo Clinic and the UIUC Campus. This will enable the use of traditional and non-traditional learning environments

and delivery models for pre-service and in-service healthcare professionals, future health researchers, and self-educating communities. These programs will use discovery science and computational medicine to integrate the latest genomic, molecular and clinical sciences into personalized care, as well as assessing and providing real-time, point-of-care educational tools.

The Mayo-Illinois Alliance will allow interdisciplinary health sciences advances leading towards precision healthcare. These advances will be through combining the computational analysis, bioinformatics and supercomputer expertise of UIUC with the medical informatics and clinical practice expertise of the Mayo Clinic for biomarker discovery and systems medicine analysis. The Mayo-Illinois Alliance aims to develop new and innovative processes that facilitate the translation of genomics and other high-dimensional data into clinical care. The Mayo-Illinois Alliance aims to build upon microbiome expertise of UIUC with the research and clinical practice expertise of the Mayo Clinic to provide a new understanding of the role of the microbiome in disease and, eventually, new diagnostics and therapeutics which leverage this new understanding. The outcomes will be new diagnostic, point-of-care innovations, and theranostic assays that will transform the practice of medicine, driven by an integrative framework across high-throughput platforms, knowledge sources, and real-time clinical data tailored for individualized patient care.

CARL A. GUNTERComputer Science

ResearchFoundations and applications of cyber-security, including the development of

formal methods and models for reasoning about security protections and the application of such models to Internet security risks like Denial of Service. Recent focus has been on security and privacy considerations for the Smart Grid and Health Information Technology (HIT). Techniques for protecting electric power meters and substation communication networks have been developed in the Smart Grid area. Techniques for analysis of audit logs in hospitals and protections for health data on mobile phones have been developed in the HIT area.

Honors• Director, Illinois Security Lab

• Director, Health Information Technology Center (HITC)

• Director, Strategic Advanced Research Projects on Security (SHARPS)

Start-upsProfessor Gunter was a founder of Probaris Technologies, a company that sells Personal Identify Verification (PIV) and PIV interoperable (PIV-I) credential solutions. Its customers include a number of major federal government


by the International Bird Strike Committee, none of the existing systems to prevent bird strikes on airfields are adequate. The reasons include habituation by birds to these systems; movement of birds to other parts of the area, or scattering of them all over the airfield; and the tendency of birds to come back when a threat has gone. The only proven lasting way of removing birds is by using live birds of prey, but real birds are too difficult to control and train. An alternative is to study and extract the behaviors and dynamics of real birds in order to develop and deploy a robotic lookalike.

SOON-JO CHUNGAerospace Engineering

ResearchNonlinear control theory, aerial robotics, bioinspired flight dynamics, flight controls,

spacecraft formation flying, and estimation theory for vision-based navigation.

Honors• National Science Foundation CAREER

Award, 2013

• Air Force Office of Scientific Research Young Investigator Award, 2008

Talk

Revolutionary Aerial Drones: Development of Robotic Falcons to Prevent Airport Bird StrikesThe intelligence of birds manifests itself in the evasive talents of flocks of birds and our research attempts to recreate that intelligence through the challenge of applying a bird-like robot to the problem of preventing aircraft/bird collisions near airports. According to surveys

agencies including Bureau of Land Management, the Social Security Administration, and the Patent and Trade Office. www.probaris.com

TalkSix Research Challenges for the Security and Privacy of Health Information TechnologyHealth Information Technology (HIT) has the potential to improve the health of individuals of all ages, aid medical research, and reduce the costs of delivering healthcare, but its effective use and acceptance by the public and healthcare professionals depend on employing proper protections for the security and privacy of health information.

While considerable progress can be made by applying current best practices for managing data, there are a number of areas specific to HIT where more research is needed to provide technology to support better practices. At least six key areas need to be addressed: (1) access controls and audit, (2) encryption and trusted base, (3) automated policy, (4) mobile health (mHealth), (5) identification and authentication, and (6) data segmentation and de-identification. This talk will discuss each of these challenges and some of the efforts being made to address them.

Advanced Materials and Engineering

Demonstration of autonomous bird-like robot making

a precision landing.


The objective of our research, motivated by the problem of keeping airfields clear of disruptive avian flocks, is to develop control and sensing strategies for bird-like flapping robots that can be deployed in swarms to fend off “antagonists.” This project presents the bio-inspired approaches to novel control strategies, vision-based sensing solutions, and strategies for cooperative pursuit and herding that will be gleaned from the literature and observations of the behavior of birds.

This project will result in both fundamental scientific knowledge and a practical application revolving around the development of highly maneuverable unmanned aerial vehicles based on flapping-wing robots.

Society as a whole stands to benefit immensely from robotic birds that can effectively prevent bird strikes, which cause airplane crashes and millions of dollars annually in damage. Furthermore, because of their high aerodynamic efficiency in forward flight, articulated-winged flapping aerial drones equipped with sensors could have tremendous value by being able to inspect hazardous areas.

LYNFORD GODDARDElectrical and Computer Engineering

ResearchThe ways that light, and lasers

in particular, can be used for sensing and

measurement, communications, and data processing. The research focuses on fabricating, characterizing, and modeling individual lasers and photodetectors, photonics-based sensors, instrumentation, and integrated circuits, as well as developing new processing, inspection, and characterization techniques, and testing novel semiconductor materials and devices.

Honors• AAAS Early Career Award for Public

Engagement with Science, 2011

• Presidential Early Career Award for Scientists and Engineers (PECASE), 2010


TalkIn-situ Optical Inspection and Metrology for Advanced Manufacturing ProcessesOur team developed diffraction phase microscope (DPM) for the inspection and metrology of semiconductor materials and nano-electronic devices. Our capabilities can enable non-destructive inline mid-process monitoring and control during device fabrication.

Figure 1a shows the DPM instrument we built, which has a 31 µm by 27 µm field of view, sub-1nm vertical resolution, and a diffraction limited lateral resolution of 360 nm. The polarization, mode profile, and coherence properties are set using optical components to the left of the microscope (dotted rectangle). The instrument’s core is the compact common-path Mach-Zehnder interferometer to the right. The grating copies the fields and the Fourier plane filter forms the image and reference beams that interfere at the CCD camera. Phase and amplitude images are retrieved in software and a topographic height map is computed.

Fig. 1. (a) DPM system. (b) Detection of an isolated dot type defect (red

rectangle) in a 22nm node wafer using a 2nd order difference tripole

low-pass filtered phase image. (c) Real-time imaging during wet etching of

UIUC logo provides instantaneous depth and etch rate. (d) Delamination of

Pd during H2 exposure.


supercomputers. Future Exaflop HPC (operateing at 10^18 FLOP/sec operation) optical links are essential for inter- and intra- chip and board connect. We will review today’s state-of-the-art VCSEL based TOSA and ROSA optical interconnect and the limitation of optical frequency response of oxide confined VCSEL (~7.5 µm aperture) and Nano-VCSEL (~ 2 µm aperture). The diode based laser (includes VCSEL) has a limited BW (< 30 GHz). Thus, the data rate will be limited to 50Gb/s @.1 pJ/bit.

In 2003, Feng (with Holonyak) arrived at the conclusion that the direct-gap, high current density heterojunction bipolar transitor (HBT) operated at .5 THz should possess fast radiative recombination lifetime toward picosecond.

The result is a unique transitor in form and operation, as well as a unique three-terminal laser. By improving the device design, the direct modulating speed of the transitor laser is able to approach the transitor speed. We have also demonstrated a direct modulated transistor laser with clear eye-diagram operation at 40 Gb/s @ 88 fJ/bit. Further reduction of optical volume in the transistor laser as the vertical cavity transistor laser (VCTL) can improve data/power efficiency towards ~ 50 fJ/bit @100 Gb/s operation and open up a new frontier of energy efficient optical interconnection.

• Fellow, Optical Society of America (OSA), 2003


TalkNano Transistor Laser for Energy Efficient Optical InterconnectThe optical link revolutionalized the telecom industry in 1980 and datacom in 1990. Since 2005, low cost multimode short-haul optical links have begun to replace copper electrical interconnect in high performance

A subset of typical DPM results is presented in Fig. 1b-1d, including:

• detecting a 35 nm × 70 nm isolated defect in a densely patterned 22nm node silicon wafer

• in-situ monitoring of semiconductor height while wet etching

• observation of the delamination of palladium from a silicon wafer during hydrogen exposure

MILTON FENGElectrical and Computer Engineering, Micro and Naotechnology Lab

ResearchBreakthrough device and integrated circuit

and antenna technology toward THz operation. In 2003, Professor Feng (with Professor Nick Holonyak) invented the Transistor Laser, and in 2004, he demonstrated the first quantum-well transistor laser. Both opened up new frontiers in optoelectronics integration as well as fast laser modulation, switching and signal processing.

Honors• Recipient of Optical Society of America (OSA)

R. W Wood Prize, 2013

• America Institute of Physics selected “Room Temperature CW Operation of Transistor Laser” as top 5 paper published in the 43 years history of Applied Physics Letters in 2006

Mixed signal/microwave circuit design for

device modeling.


operating principles as well as projected advantages of this device are reviewed, as well as system applications.

XIULING LIElectrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, Materials Research Laboratory, Micro and Nanotechnology Lab

ResearchNanostructured semiconductor materials and devices, including 1) a 2D for 3D platform

for rolled-up passive electronic components which can reduce inductor footprint more than 100 times without sacrificing performance. 2) Facile and versatile high aspect ratio semiconductor structure formation by metal-assisted chemical etching. 3) 3D III-V transistors.

output power and operating wavelength. This functionality is achieved by placing a cascade structure capable of long-wavelength emission into the base-collector junction of a bipolar junction transistor. Wavelength is controlled via the base-collector junction voltage, while optical power is controlled via current injection through the emitter-base junction. The unique structure of the device enables dithering of the wavelength around a sample absorption peak at fixed output power for chemical detection, high-speed amplitude modulation around a fixed wavelength for communications, or simultaneous amplitude and frequency modulation for communications applications requiring advanced modulation schemes (multiple bits per symbol). The

JOHN DALLESASSEElectrical and Computer Engineering, Micro and Nanotechnology Lab

ResearchPhotonic integration for

next-generation optical networks, enabling the existing fiber infrastructure to carry more data.

Honors• Fellow, Optical Society of America

(OSA), 2013

Start-upsSkorpios, Inc. brings the proven scale, cost structure and maturity of the silicon industry to optical communications. Skorpios is developing a range of optical communications products for both custom and multi-source agreement (MSA) applications.www.skorpiosinc.com

TalkThe TIQCL: A Novel Mid-IR Emitter for Chemi-cal Sensing and Biological ImagingAccurate detection of chemical species for industrial process monitoring, emissions control, homeland security, defense, and healthcare applications requires the availability of high-power, tunable coherent optical sources in the mid-IR through THz regions of the electromagnetic spectrum. The transistor-injected quantum-cascade laser (TIQCL) is proposed as a novel, 3-terminal device that provides independent control of device optical

Rolled-up inductor

design from the

laboratory of Xiuling Li


Honors• Dean’s Award for Excellence in Research, 2012

• ONR Young Investigator Program Award, 2011

• DARPA Young Faculty Award, 2009

• National Science Foundation (NSF) CAREER Award, 2008

TalkShrinking Inductors, Transformers, and MorePassive components including inductors occupy most of the on-chip areas in integrated circuits (ICs). In addition, they typically suffer from significant performance problems especially in high frequency band. These include parasitic coupling capacitance, Ohmic and dielectric loss due to the close proximity of the devices to the substrate, as well as electromagnetic radiation loss due to the 2D open structure. To some extent, the overall performance of the current logic circuits, MMIC, and RFICs is limited by the passive devices on them.

Strain induced self-rolled-up membrane technology provides a 3D hierarchical architectural platform for miniaturizing passive components, improving performance without introducing fabrication complexity. Designs of inductors, transformers, filters, and coaxial transmission line, etc. using the 3D spiral form with ultra-small on-chip footprint will be introduced. Experimental feasibility will be demonstrated.

WILLIAM P. KINGMechanical Science & Engineering, Beckman Institute for Advanced Science and Technology

ResearchMicro-manufacturing,

advanced microscopy techniques, and materials for power and energy applications.

Honors• Gustus-Larson Award for Achievement in

Mechanical Engineering, 2013

• Two-time winner of the R&D 100 Award

• ASME Fellow

• Technology Review’s list of the most innova-tive people under the age of 35, 2006

Start-upAnasys Instruments Inc., materials characterization and microscopy. www.anasysinstruments.com

Hoowaki LLC, tooling for micro-manufactuirng applications. www.hoowaki.com

Advisor or board member at an additional 10 startups.

TalkDigital ManufacturingInformation technology has transformed nearly every aspect of American business, except for the manufacturing shop floor. The application of digital technologies for manufacturing productivity improvements is an important and urgent problem for the entire American economy. In 2013, President Obama announced that the federal government would award $70M to found a new manufacturing institute focused on Digital Manufacturing. This talk describes the Midwest regional response to this opportunity.

PAUL BRAUNMaterials Science and Engineering, Beckman Institute for Advanced Science and Technology

ResearchThree-dimensionally

meso and nanostructured structured materials can provide unique functionalities. Materials developed by his group containing structure on these length scales have been found to exhibit

Illustration of ions flowing between three-dimensional

micro-electrodes in a lithium-ion battery.

interesting and important thermal, optical, mechanical, chemical, and electrochemical properties. This research has resulted in self-healing coatings, high power batteries, and biochemical sensors.

Honors• Friedrich Wilhelm Bessel Research

Award, 2010

• Defense Science Study Group, 2010-2011

• Xerox Award for Faculty Research, 2004 & 2009

Start-UpsAutonomic Materials Inc. offers innovative self-healing technologies that extend coating lifetimes, minimizing upkeep and repair. AMI’s self-healing technology repairs damage to coatings when it occurs without manual intervention, which extends lifetime and performance. www.autonomicmaterials.com

Xerion Advanced Battery is leading the development and engineering of advanced nano-structured battery systems. XAB is developing and commercializing next generation ultra-high power, high energy lithium ion batteries using scalable manufacturing methods. www.xerionbattery.com

TalkIn vivo Continuous Glucose Monitoring with Photonic Crystal SensorsDiabetes is a worldwide epidemic with the number of sufferers expected to reach 366

million by 2030, and although continuous glucose monitoring (CGM) has garnered considerable attention due to the advantages in maintaining tight glycemic control, successes in continuous monitoring have been limited. CGM requires sensors with precision, accuracy, sensitivity, stability, and speed. If all these characteristics are not present, most sufferers will continue to use “prick and measure” methods.

We have developed a new class of hydrogels suitable for CGM that volumetrically respond to glucose with all the required features. A photonic crystal incorporated into these glucose responsive hydrogels to provide signal transduction (the hydrogel volume change can now be directly recorded by an optical spectrometer). These sensor materials meet the key CGM requirements in both physiological buffer solutions and blood serum at body temperature. Miniaturized devices suitable for in vivo blood glucose monitoring can be formed using such sensor materials.

ANDREW ALLEYNEMechanical Science and Engineering

ResearchModeling, analysis and controller design for

complex mechanical systems. Development of simulation tools and decision making algorithms balancing rigorous theoretical

approaches with high impact practical applications. Broad application domain spanning energy systems, manufacturing systems, transportation and agriculture.

Honors• ASME Gustus Larson Award, 2008

• ASME Fellow, 2005

• Fulbright Fellow, 2002


TalkSimulation and Analysis for Dynamical Energy SystemsMany energy systems, particularly for mobile applications, operate in highly transient modes. It is necessary to have appropriate modeling tools to understand the systems-level interactions of components in order to optimize both design and operation. We have developed simulation tools that are fast, compact, and accurate and represent a variety of systems related to energy transport. Moreover, these tools are very modular allowing for rapid reconfiguration of different system architectures and modifications of individual designs.

We have demonstrated the effectiveness of these tools on commercial platforms. The have been found to be extremely useful, particularly when designing systems to interface with on-line controllers or diagnostics.

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