session title date time submission id program no. 1st ... · the 46th annual meeting of the...

13
The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title 100298 1-A-W1-1-O/P Sho SHIBATA Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo, Japan Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD 100301 1-A-W1-2-P Minoru Takeuchi Dept. of Animal Medical Science, Kyoto Sangyo University, Kyoto, Japan <strong>Effect of H</strong><strong>ot Water Extract from Agaricus Blazei Murill on Lipopolysaccharide (LPS) -induced Lung Inflammation and the Immunological Mechanism</strong> 100041 1-A-W1-3-O/P Satoko Tahara-Hanaoka Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan Inhibition of house dust mite-induced Th2 responses by Allergin-1 immunoreceptor on dendritic cells 100100 1-A-W1-4-O/P Koji Hayashizaki Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation 100235 1-A-W1-5-P Ryuichi Nagashima Division of Cancer Biology and Therapeutics, Miyagi Cancer Certer Reserch Institute, Natori, Japan <strong>Nrf2 activation suppressed lung allergic inflammation induced by type2-innate lymphoid cells.</strong> 100441 1-A-W1-6-P Jung Yeon Hong Department of Pediatrics and Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea <strong>Chitotriosidase Regulation of Allergen-induced Airway Inflammation Airways Hyperresponsiveness and Foxp3<sup>+</sup> Treg Cells</strong> 100450 1-A-W1-7-P Mi Na Kim Department of Pediatrics and Institute of Allergy, Brain Korea 21 PLUS Project for Medical science, Yonsei University College of Medicine, Seoul, Republic of Korea ALCAM on dendritic cell contributes Th2 response in allergic airway inflammation 100321 1-A-W1-8-P Tomohiro Tamachi Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan A20 (<em>Tnfaip3</em>) expressed in T cells suppresses Th2 cell-mediated allergic airway inflammation in mice 100189 1-A-W1-9-O/P Aiko Saku Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan Lung epithelial fucosylation promotes the development of house dust mite (HDM)-induced allergic airway inflammation. 100268 1-A-W1-10-O/P Tomomitsu Miyasaka Division of Pathophysiology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan Possible involvement of CD103<sup>+</sup> dendritic cells in female-predominant Th2 priming in asthma 100356 1-A-W1-11-O/P Kentaro Fujiwara Dept. of Immunology <strong>M1 macrophages mediate attenuation of bronchial asthma by matrix-metalloproteinase- 2</strong> 100473 1-A-W1-12-P Asako Tanoue Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan The role of group III secreted phospholipase A2 in allergic asthma 100031 1-A-W1-13-P Chika Kanamori Department of Animal medical science, Faculty of Life science, Kyoto Sangyo University, Kyoto, Japan <strong>Effects of Cryptomeria Japonica pollen and cigarette smoke on immune cells</strong> 100199 1-A-W1-14-O/P Katsuhide Okunishi Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan Rab27 effector exophilin5 regulates IL-33 signaling in allergic immune responses 100590 1-A-W1-15-P Masashi Ikutani Department of Immune Regulation, Research Institute, National Center for Global Health and Medicine, Chiba, Japan Chronic IL-33-induced inflammation results in pulmonary arterial hypertrophy 100218 1-A-W1-16-P Prince Baffour Tonto Dept. of Immunology <strong>Role of eosinophils and metalloproteinase-2 in airway remodeling</strong> 100291 1-A-W1-17-O/P Kazuyuki Nakagome Department of Respiratory Medicine and Allergy Center, Saitama Medical University, Saitama, Japan Elevated periostin concentrations in the bronchoalveolar lavage fluid of eosinophilic pneumonia 100339 1-A-W1-18-P Shigeki Katoh Department of Respiratory Medicine, Kawasaki Medical School, Okayama, Japan Possible role of IL-25 in eosinophilic lung inflammation in patients with eosinophilic pneumonia 100056 1-A-W2-1-P Oji Nakamura Department of Applied Biological Chemistry, Tokyo University of Agriculture and Technology, Tokyo, Japan Effect of honeybush extracts on the murine model of pollen allergy 100064 1-A-W2-2-P Inoue Akiko Department of Otorhinolaryngology, Toho University School of Medicine, Tokyo, Japan Study of relationship of allergy and chronic rhinosinusitis 100153 1-A-W2-3-P Dong-Young Kim Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea Anti-allergic effect of intranasal vitamin D treatment by inhibiting dendritic cell activation in the allergic rhinitis mouse model 100249 1-A-W2-4-P Ayumi Fukuoka Department of Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan Cystatin SN inhibits Japanese cedar pollen-induced allergic rhinitis in mice. 100288 1-A-W2-5-P Makoto Matsui Department of Fundamental Biosciences, Shiga University of Medical Science, Otsu, Japan Role of neutrophils in the nasal mucosa in a mouse model of allergic rhinitis 100292 1-A-W2-6-P Daisuke Nagakubo Department of Fundamental Biosciences, Shiga University of Medical Science, Otsu, Japan Involvement of CCL28 in the pathogenesis of allergic rhinitis in a mouse model 100300 1-A-W2-7-O/P Masaya Matsuda Laboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan Effects of subcutaneous immunotherapy (SCIT) on regulatory T cells in pollinosis patients 100484 1-A-W2-8-O/P Kazuya Takeda Laboratory of Immune regulation, Immunology Frontier Research center, Osaka University, Suita, Japan Ectopic T-B interaction for antigen-specific IgE antibody responses in nasal polyps of Eosinophilic chronic rhinosinusitis patients 100110 1-A-W2-9-O/P Dat Nguyen-Tien Division of Molecular Biology, Research Institute for Biomedical Sciences, Tokyo University of Science <strong>A selection technique for human IgE<sup>+</sup> memory B cells and the function of the &ldquo;new&rdquo; isoform of human IgE</strong> 100113 1-A-W2-10-O/P Mariana Almeida Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan Inhibition of house dust mite-induced MAP kinase activation in dendritic cells by Allergin-1 immunoreceptor 100203 1-A-W2-11-P Hirotomo Shibaguchi Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan Gene analysis of HL-60 cells and neutrophils to generate ideal chemotactic cells for HiSAT 100205 1-A-W2-12-O/P Shihono Kato Laboratory for Innate Immune Systems, RIKEN, IMS, Kanagawa, Japan Role of ILC2 in the formation of maternal allergic inflammation and allergic susceptibility of the offspring 100232 1-A-W2-13-O/P Mio Ohashi Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan Prediction of Chemical Respiratory and Contact Sensitizers by OX40L Expressionin Dendritic Cells Using a Novel 3D Co-Culture System 100311 1-A-W2-14-O/P Kano Tanabe Department of Medical Technology, Kumamoto Health Science University, Kumamoto, Japan CaMKII regulates IgE class switch recombination via TRAF3 ubiquitination 100317 1-A-W2-15-P Akira Awaya Dermatology&amp;Epidemiology Research Institute(DERI),Totsuka,Yokohama, Japan Strategy for advance of melanocyte immunology from research on pollen-induced diseases(PID) such as Kawasaki disease(KD) - Epidemiological study of KD(13): Statistical analyses reveal epidemics of Influenza suppress or postpone KD onsets. Coadministration 100519 1-A-W2-16-O/P Ayako Takamori Atopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo, Japan <strong>Ceramide-CD300f interaction inhibits Mrgprb2-mediated mast cell activation and pseudo- allergic drug reactions in mice</strong> 100553 1-A-W2-17-P Narumi Suzuki Laboratory for Cytokine Regulation,Research Center for Integrative Medical Science ,RIKEN Yokohama Institute,Yokohama,japan E4BP4/NFIL-3 is a critical transcription factor to control TH2 attraction into inflammation site during chronic allergic responses. 100667 1-A-W2-18-P YOSHIKAWA Soichiro Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo, Japan <strong>Prolonged Ca<sup>2+</sup> influx via STIM2 is essential for cytokine-induced IL-4 production in basophil</strong> 100614 1-B-W3-1-O/P Ryota Sato Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, Japan <strong>Requirement of glycosylation machinery in Toll-like receptor responses revealed by CRISPR/Cas9 screening </strong> 100070 1-B-W3-2-O/P Sachiko Akashi-Takamura Aichi Medical University School of Medicine, Nagakute, Japan C4b binding protein negatively regulates cell-surface TLRs response 100216 1-B-W3-3-O/P Ken Takashima Department of Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan Novel Negative Regulators for MDA5-Mediated Innate Immune Response 100641 1-B-W3-4-O/P Michihiro Takahama Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan RAB2B-GARIL5 complex promotes innate immune response against DNA virus 100188 1-B-W3-5-O/P Naoya Sakaguchi Research Institute for Microbial Diseases (RIMD), Osaka University, Osaka, Japan <strong>Role of GABARAP subfamily in the regulation of non-canonical inflammasome activation</strong> 100322 1-B-W3-6-O/P Kohsuke Tsuchiya Cancer Research Institute, Kanazawa University, Kanazawa, Japan Caspase-1 serves as an apoptosis-initiating caspase in the absence of Gasdermin D (GSDMD) 100181 1-B-W3-7-O/P Ho Minh Van Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University <strong>Detection of ATP-dependent inflammatory suppression of the innate immune response in septic patients</strong> 100078 1-B-W3-8-O/P Masahiro Nagata Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Intracellular metabolite, &beta;-glucosylceramide, is an endogenous adjuvant acting through Mincle 100632 1-B-W3-9-P Yuki Nakajima Department of Immunology, Graduate School of Medicine, The University of Tokyo Identificdation of immunogenic endogenous RNA and its inhibitor 100629 1-B-W3-10-P Asuka Inoue Research and Development, Sanofi K.K., Tokyo, Japan Immune regulation by inhibitory oligonucleotide ISM ODN for HMGB1 in inflammatory disease models 100522 1-B-W3-11-P Motoya Murase Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), Nara, Japan Intravesicular acidification regulates lipopolysaccharide inflammation and tolerance through Toll-like receptor 4 trafficking 100379 1-B-W3-12-P Rina Sugimoto Department of Cell Biological Science, Graduate School of Life Science, Hokkaido University, Sapporo, Japan Evaluation system for receptor expression and function in the intestinal stem cell niche 100533 1-B-W3-13-P Hideki Sanjo Department of Molecular and Cellular Immunology, Shinshu University Schhol of Medicine, Nagano, Japan Loss of TAK1 leads to TLR-driven macrophage cell death and inflammation that occur by a TNF- independent mechanism 100095 1-B-W3-14-P Shimpei Watanabe R&amp;D Innovation Group, Kracie Holdings, Ltd., Tokyo, Japan Arctigenin suppresses the activation of NLRP3 and AIM2 inflammasomes. 100382 1-B-W3-15-P Takumi Adachi Department of Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan Purification and characterization of a unique DAMP of a potent inducer of IL-33 expression in non- hematopoietic cells Odd Number / 16:30-17:30 Even Number / 17:30-18:30 Odd Number / 16:30-17:30 Even Number / 17:30-18:30 Odd Number / 16:30-17:30 Even Number / 17:30-18:30 W3 Endogenous innate immunity and inflammation-1 Dec. 12 (Tue.), 2017 W1 Allergy-1 : Lower airway allergic inflammation Dec. 12 (Tue.), 2017 W2 Allergy-2: Upper airway allergic inflammation and allergic responses Dec. 12 (Tue.), 2017 1 / 13

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Page 1: Session Title Date Time Submission ID Program No. 1st ... · The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster Session Title Date Time Submission ID

The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100298 1-A-W1-1-O/P Sho SHIBATA Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo, JapanMonocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema

through MMP-12 production in a mouse model of COPD

100301 1-A-W1-2-P Minoru Takeuchi Dept. of Animal Medical Science, Kyoto Sangyo University, Kyoto, Japan<strong>Effect of H</strong><strong>ot Water Extract from Agaricus Blazei Murill on

Lipopolysaccharide (LPS) -induced Lung Inflammation and the Immunological Mechanism</strong>

100041 1-A-W1-3-O/P Satoko Tahara-HanaokaDepartment of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba,

JapanInhibition of house dust mite-induced Th2 responses by Allergin-1 immunoreceptor on dendritic cells

100100 1-A-W1-4-O/P Koji HayashizakiDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba,

JapanMyosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation

100235 1-A-W1-5-P Ryuichi NagashimaDivision of Cancer Biology and Therapeutics, Miyagi Cancer Certer Reserch Institute,

Natori, Japan

<strong>Nrf2 activation suppressed lung allergic inflammation induced by type2-innate lymphoid

cells.</strong>

100441 1-A-W1-6-P Jung Yeon HongDepartment of Pediatrics and Institute of Allergy, Brain Korea 21 PLUS Project for

Medical Science, Yonsei University College of Medicine, Seoul, Korea

<strong>Chitotriosidase Regulation of Allergen-induced Airway Inflammation Airways

Hyperresponsiveness and Foxp3<sup>+</sup> Treg Cells</strong>

100450 1-A-W1-7-P Mi Na KimDepartment of Pediatrics and Institute of Allergy, Brain Korea 21 PLUS Project for

Medical science, Yonsei University College of Medicine, Seoul, Republic of KoreaALCAM on dendritic cell contributes Th2 response in allergic airway inflammation

100321 1-A-W1-8-P Tomohiro TamachiDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba

University, Chiba, Japan

A20 (<em>Tnfaip3</em>) expressed in T cells suppresses Th2 cell-mediated allergic airway

inflammation in mice

100189 1-A-W1-9-O/P Aiko SakuDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba

University, Chiba, Japan

Lung epithelial fucosylation promotes the development of house dust mite (HDM)-induced allergic

airway inflammation.

100268 1-A-W1-10-O/P Tomomitsu MiyasakaDivision of Pathophysiology, Department of Pharmaceutical Sciences, Faculty of

Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai,

Japan

Possible involvement of CD103<sup>+</sup> dendritic cells in female-predominant Th2 priming in

asthma

100356 1-A-W1-11-O/P Kentaro Fujiwara Dept. of Immunology<strong>M1 macrophages mediate attenuation of bronchial asthma by matrix-metalloproteinase-

2</strong>

100473 1-A-W1-12-P Asako TanoueDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences,

Kagoshima University, Kagoshima, JapanThe role of group III secreted phospholipase A2 in allergic asthma

100031 1-A-W1-13-P Chika KanamoriDepartment of Animal medical science, Faculty of Life science, Kyoto Sangyo

University, Kyoto, Japan<strong>Effects of Cryptomeria Japonica pollen and cigarette smoke on immune cells</strong>

100199 1-A-W1-14-O/P Katsuhide Okunishi Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan Rab27 effector exophilin5 regulates IL-33 signaling in allergic immune responses

100590 1-A-W1-15-P Masashi IkutaniDepartment of Immune Regulation, Research Institute, National Center for Global

Health and Medicine, Chiba, JapanChronic IL-33-induced inflammation results in pulmonary arterial hypertrophy

100218 1-A-W1-16-P Prince Baffour Tonto Dept. of Immunology <strong>Role of eosinophils and metalloproteinase-2 in airway remodeling</strong>

100291 1-A-W1-17-O/P Kazuyuki NakagomeDepartment of Respiratory Medicine and Allergy Center, Saitama Medical University,

Saitama, JapanElevated periostin concentrations in the bronchoalveolar lavage fluid of eosinophilic pneumonia

100339 1-A-W1-18-P Shigeki Katoh Department of Respiratory Medicine, Kawasaki Medical School, Okayama, Japan Possible role of IL-25 in eosinophilic lung inflammation in patients with eosinophilic pneumonia

100056 1-A-W2-1-P Oji NakamuraDepartment of Applied Biological Chemistry, Tokyo University of Agriculture and

Technology, Tokyo, JapanEffect of honeybush extracts on the murine model of pollen allergy

100064 1-A-W2-2-P Inoue Akiko Department of Otorhinolaryngology, Toho University School of Medicine, Tokyo, Japan Study of relationship of allergy and chronic rhinosinusitis

100153 1-A-W2-3-P Dong-Young KimDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University

College of Medicine, Seoul, Korea

Anti-allergic effect of intranasal vitamin D treatment by inhibiting dendritic cell activation in the allergic

rhinitis mouse model

100249 1-A-W2-4-P Ayumi Fukuoka Department of Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan Cystatin SN inhibits Japanese cedar pollen-induced allergic rhinitis in mice.

100288 1-A-W2-5-P Makoto MatsuiDepartment of Fundamental Biosciences, Shiga University of Medical Science, Otsu,

JapanRole of neutrophils in the nasal mucosa in a mouse model of allergic rhinitis

100292 1-A-W2-6-P Daisuke NagakuboDepartment of Fundamental Biosciences, Shiga University of Medical Science, Otsu,

JapanInvolvement of CCL28 in the pathogenesis of allergic rhinitis in a mouse model

100300 1-A-W2-7-O/P Masaya MatsudaLaboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan

University, Osaka, JapanEffects of subcutaneous immunotherapy (SCIT) on regulatory T cells in pollinosis patients

100484 1-A-W2-8-O/P Kazuya TakedaLaboratory of Immune regulation, Immunology Frontier Research center, Osaka

University, Suita, Japan

Ectopic T-B interaction for antigen-specific IgE antibody responses in nasal polyps of Eosinophilic

chronic rhinosinusitis patients

100110 1-A-W2-9-O/P Dat Nguyen-TienDivision of Molecular Biology, Research Institute for Biomedical Sciences, Tokyo

University of Science

<strong>A selection technique for human IgE<sup>+</sup> memory B cells and the function of the

&ldquo;new&rdquo; isoform of human IgE</strong>

100113 1-A-W2-10-O/P Mariana AlmeidaDepartment of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba,

Japan

Inhibition of house dust mite-induced MAP kinase activation in dendritic cells by Allergin-1

immunoreceptor

100203 1-A-W2-11-P Hirotomo Shibaguchi Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan Gene analysis of HL-60 cells and neutrophils to generate ideal chemotactic cells for HiSAT

100205 1-A-W2-12-O/P Shihono Kato Laboratory for Innate Immune Systems, RIKEN, IMS, Kanagawa, Japan Role of ILC2 in the formation of maternal allergic inflammation and allergic susceptibility of the offspring

100232 1-A-W2-13-O/P Mio OhashiDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical

University, Tokyo, Japan

Prediction of Chemical Respiratory and Contact Sensitizers by OX40L Expressionin Dendritic Cells

Using a Novel 3D Co-Culture System

100311 1-A-W2-14-O/P Kano TanabeDepartment of Medical Technology, Kumamoto Health Science University, Kumamoto,

JapanCaMKII regulates IgE class switch recombination via TRAF3 ubiquitination

100317 1-A-W2-15-P Akira Awaya Dermatology&amp;Epidemiology Research Institute(DERI),Totsuka,Yokohama, Japan

Strategy for advance of melanocyte immunology from research on pollen-induced diseases(PID) such

as Kawasaki disease(KD) - Epidemiological study of KD(13): Statistical analyses reveal epidemics of

Influenza suppress or postpone KD onsets. Coadministration

100519 1-A-W2-16-O/P Ayako TakamoriAtopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo,

Japan

<strong>Ceramide-CD300f interaction inhibits Mrgprb2-mediated mast cell activation and pseudo-

allergic drug reactions in mice</strong>

100553 1-A-W2-17-P Narumi SuzukiLaboratory for Cytokine Regulation,Research Center for Integrative Medical Science

,RIKEN Yokohama Institute,Yokohama,japan

E4BP4/NFIL-3 is a critical transcription factor to control TH2 attraction into inflammation site during

chronic allergic responses.

100667 1-A-W2-18-P YOSHIKAWA Soichiro Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo, Japan<strong>Prolonged Ca<sup>2+</sup> influx via STIM2 is essential for cytokine-induced IL-4 production

in basophil</strong>

100614 1-B-W3-1-O/P Ryota SatoDivision of Innate Immunity, The Institute of Medical Science, The University of Tokyo,

Japan

<strong>Requirement of glycosylation machinery in Toll-like receptor responses revealed by

CRISPR/Cas9 screening </strong>

100070 1-B-W3-2-O/P Sachiko  Akashi-Takamura Aichi Medical University School of Medicine, Nagakute, Japan C4b binding protein negatively regulates cell-surface TLRs response

100216 1-B-W3-3-O/P Ken TakashimaDepartment of Immunology, Graduate School of Medicine, Hokkaido University,

Sapporo, JapanNovel Negative Regulators for MDA5-Mediated Innate Immune Response

100641 1-B-W3-4-O/P Michihiro Takahama Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan RAB2B-GARIL5 complex promotes innate immune response against DNA virus

100188 1-B-W3-5-O/P Naoya Sakaguchi Research Institute for Microbial Diseases (RIMD), Osaka University, Osaka, Japan<strong>Role of GABARAP subfamily in the regulation of non-canonical inflammasome

activation</strong>

100322 1-B-W3-6-O/P Kohsuke Tsuchiya Cancer Research Institute, Kanazawa University, Kanazawa, Japan Caspase-1 serves as an apoptosis-initiating caspase in the absence of Gasdermin D (GSDMD)

100181 1-B-W3-7-O/P Ho Minh VanDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical

and Health Sciences, Hiroshima University

<strong>Detection of ATP-dependent inflammatory suppression of the innate immune response in

septic patients</strong>

100078 1-B-W3-8-O/P Masahiro NagataDepartment of Molecular Immunology, Research Institute for Microbial Diseases,

Osaka University, Osaka, JapanIntracellular metabolite, &beta;-glucosylceramide, is an endogenous adjuvant acting through Mincle

100632 1-B-W3-9-P Yuki Nakajima Department of Immunology, Graduate School of Medicine, The University of Tokyo Identificdation of immunogenic endogenous RNA and its inhibitor

100629 1-B-W3-10-P Asuka Inoue Research and Development, Sanofi K.K., Tokyo, Japan Immune regulation by inhibitory oligonucleotide ISM ODN for HMGB1 in inflammatory disease models

100522 1-B-W3-11-P Motoya MuraseGraduate School of Biological Sciences, Nara Institute of Science and Technology

(NAIST), Nara, Japan

Intravesicular acidification regulates lipopolysaccharide inflammation and tolerance through Toll-like

receptor 4 trafficking

100379 1-B-W3-12-P Rina SugimotoDepartment of Cell Biological Science, Graduate School of Life Science, Hokkaido

University, Sapporo, JapanEvaluation system for receptor expression and function in the intestinal stem cell niche

100533 1-B-W3-13-P Hideki SanjoDepartment of Molecular and Cellular Immunology, Shinshu University Schhol of

Medicine, Nagano, Japan

Loss of TAK1 leads to TLR-driven macrophage cell death and inflammation that occur by a TNF-

independent mechanism

100095 1-B-W3-14-P Shimpei Watanabe R&amp;D Innovation Group, Kracie Holdings, Ltd., Tokyo, Japan Arctigenin suppresses the activation of NLRP3 and AIM2 inflammasomes.

100382 1-B-W3-15-P Takumi Adachi Department of Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanPurification and characterization of a unique DAMP of a potent inducer of IL-33 expression in non-

hematopoietic cells

Odd Number /

16:30-17:30

Even Number /

17:30-18:30

Odd Number /

16:30-17:30

Even Number /

17:30-18:30

Odd Number /

16:30-17:30

Even Number /

17:30-18:30

W3

Endogenous innate

immunity and

inflammation-1

Dec. 12

(Tue.), 2017

W1Allergy-1 : Lower airway

allergic inflammation

Dec. 12

(Tue.), 2017

W2

Allergy-2: Upper airway

allergic inflammation and

allergic responses

Dec. 12

(Tue.), 2017

1 / 13

Page 2: Session Title Date Time Submission ID Program No. 1st ... · The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster Session Title Date Time Submission ID

The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100040 1-B-W4-1-O/P Ayako Wakabayashi Department of Microbiology and Immunology, Nippon Medical School, Tokyo, JapanEnhancement of epithelial cell death, cytoplasmic HMGB1 expression in IECs, and increase of HMGB1

release by oral CT-stimulation

100529 1-B-W4-2-O/P Eri KumakiDepartment of Pediatrics and Developmental biology, Tokyo Medical and Dental

University Graduate School of Medical and Dental Sciences, Tokyo, JapanAbberant Neutrophil Function in <em>PSTPIP1</em> mutations

100325 1-B-W4-3-O/P Akiko Ishitani Nara Medical University, Kashihara, Nara, Japan

<em>The three faces of F: HLA-F as a ligand for KIRs, a cofactor in antigen presentation, and a

receptor on B cells and monocytes, combined in an immunoregulatory capacity centered on the

inflammatory response.</em>

100353 1-B-W4-4-O/P Toshiaki Totoki Dept. of Immunology<strong>Overexpression of protein S exacerbates carbon tetrachloride-induced liver injury and

fibrosis</strong>

100493 1-B-W4-5-O/P Maehara AkieAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine,

Tokyo, Japan

Identification and characterization of a novel mutation of NLRP1 in a patient with a rare disease

involving severe liver fibrosis

100619 1-B-W4-6-O/P Kiyoharu FukushimaDepartment of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka

University, Osaka, Japan.Screening of causative genes for fibrosis development in mice.

100474 1-B-W4-7-O/P Yukari SaitoDepartment of Immune Regulation, Research Center for Hepatitis and Immunology,

Research Institute, National Center for Global Health and Medicine, Chiba, Japan

Activation of NK/group1-innate lymphoid cells in adipose tissues depends on the composition of fatty

acids in high fat diet.

100270 1-B-W4-8-O/P Kafi N. Ealey Laboratory for Innate Immune Systems, RIKEN IMS, Yokohama, JapanMechanisms for the regulation of adipose tissue expansion and remodeling by group 2 innate lymphoid

cells

100002 1-B-W4-9-O/P Toshihiko Kobayashi Department of Molecular Immunology &amp; Inflammation, Research Institute, NCGM Regulatory role of an oligopeptide transporter SLC15A3 during the systemic inflammation

100642 1-B-W4-10-P Yoshihito SudaDepartment of Food, Agricultural and Environmental Sciences, Miyagi University,

Miyagi, JapanExpression of complement components, C3 in lung and liver of aging mouse

100202 1-B-W4-11-P HAI T PHUNGDepartment of Microbiology and Immunology, Tohoku University Graduate School of

Medicine, Sendai, Japan

TNF receptor-associated factors 5 expressed in non-hematopoietic cells augments acute colonic

damage induced by dextran sulfate sodium

100316 1-B-W4-12-P Kyohei Nishino Department of Medicine, Shiga University of Medical Science Analysis of the role of autophay in dextran sodium sulfate (DSS) induced experimental colitis

100212 1-B-W4-13-P Masaaki Toda Dept of Immunology<strong>Epigenetic mechanisms mediate the antiatherosclerotic activity of low consumption of

alcohol</strong>

100077 1-B-W4-14-P Takashi Mino Institute for Frontier Life and Medical Sciences, Kyoto University <strong>Regnase-1 regulates inflammatory mRNAs during pioneer rounds of translation</strong>

100355 1-B-W4-15-P Yasuharu WatanabeDepartment of Immunobiology and Pharmacological Genetics, Graduate School of

Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama,

Japan

<strong>The interaction of neutrophils with adipocytes plays a key role in the infiltration of macrophage

into the adipose tissue</strong>

100659 1-B-W4-16-P Hiroshi Nihira Department of Pediatrics, Faculty of Medicine, Kyoto University, Kyoto, JapanDeficiency of adenosine deaminase 2 (DADA2) in Japan: Clinical and genetic diversity in Japanese

patients.

100588 1-C-W5-1-O/P Ben RaveneyDepartment of Immunology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo,

Japan

Eomes-positive cytotoxic T helper cells: a new pathogenic immune cell subset in secondary

progressive multiple sclerosis?

100535 1-C-W5-2-O/P Chenyang ZHANGDepartment of Immunology, National Institute of Neuroscience, National Center of

Neurology and Psychiatry, Kodaira, Tokyo, Japan.

<strong>Antigen-presenting cells promote Eomes expression in helper T cells through ectopic

expression of prolactin under chronic neuroinflammation</strong>

100405 1-C-W5-3-O/P Youwei LinDepartment of Immunology, National Institute of Neuroscience, National Center of

Neurology and Psychiatry

Inverse vaccination by superior dominant peptide inhibit the reactivity to disease-associated antigens

and promote tissue-repair capacity in stabilized antigen-specific regulatory T cells to control of

relapsing and progression of animal model of multiple

100158 1-C-W5-4-O/P Fumitaka Sato Kindai University, Osakasayama, JapanProtective and detrimental effects of curdlan, a Th17 cell inducer, in immune-mediated demyelination

induced by a neurotropic viral infection

100342 1-C-W5-5-O/P Fumihiro Yanagimura Department of Neurology, Brain Research Institute, Niigata University, Niigata, JapanDifferential dynamics of mucosal-associated invariant T cells in the blood and the CNS lesions of

patients with neuromyelitis optica

100506 1-C-W5-6-O/P Daisuke KamimuraPsychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine,

Hokkaido University, Sapporo, Japan

<strong>Light-Gateway Reflex; Photopic light suppresses retinal inflammation via down-regulation of a

regional adrenergic pathway</strong>

100129 1-C-W5-7-O/P Satoshi YamadaDepartment of Intelligent Mechanical Engineering, Okayama University of Science,

Okayama, JapanComputer model of a gateway of immune cells across blood-brain barrier

100528 1-C-W5-8-O/P Yasunobu ArimaDivision of Psychoimmunology, Institute for Genetic Medicine and Graduate School of

Medicine, Hokkaido University, Sapporo, Japan

Stress-Gateway Reflex, which establishes brain micro-inflammation at specific vessels, creates a new

neural pathway, which induces the dysregulation of organ homeostasis

100014 1-C-W5-9-P Yusei Miyazaki Hokkaido Medical Center, Sapporo, Japan<strong>Fingolimod induces BAFF and expands circulating transitional B cells without activating

memory B cells and plasma cells in multiple sclerosis</strong>

100054 1-C-W5-10-P Koji ShinodaDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences,

Kyushu University, Fukuoka, Japan

A distinct repertoire of the &gamma;&delta; T cell population is associated with disease severity of

multiple sclerosis

100524 1-C-W5-11-P Natsumi Nakayama Laboratory of Biochemistry, Azabu University The role of gangliosides in CNS autoimmune diseases

100602 1-C-W5-12-P AKIBA YasushiDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo,

JapanNuclear protein SATB1 is required for development of experimental autoimmune encephalomyelitis

100138 1-C-W6-1-O/P Ota MitsutoshiDivision of Psychoimmunology, Institute for Genetic Medicine, Hokkaido University,

Sapporo, Japan

<strong>NF-kB Arthritis Inducer 1 (NAI1) in chondrocytes regulates joint inflammation via NF-kB

activation</strong>

100618 1-C-W6-2-O/P Ikuma NakagawaDivision of Psychoimmunology, Institute for Genetic Medicine, Hokkaido University,

Hokkaido, Japan

<strong>Primary Sj&ouml;gren&rsquo;s syndrome-associated gene<em> STF1</em> regulates

inflammation via </strong><strong>NF-</strong><strong>k</strong><strong>B pathway</strong>

100099 1-C-W6-3-P Masato KinoshitaDepartment of Nephrology and Rheumatology, Gunma University Graduate School of

Medicine, Gunma, Japan

Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp-1 induces autoimmune

sialadenitis characterized by infiltration of CD4<sup>+</sup> T cells and B cells

100037 1-C-W6-4-O/P Kojiro SatoDepartment of Rheumatology and Applied Immunology, Saitama Medical University,

Saitama, Japan

Analysis of the function of Nfatc1 isoforms in the differentiation of osteoclasts and an attempt to make

short-form specific Nfatc1 knockout mice with the CRISPR/Cas9 system

100630 1-C-W6-5-O/P Michio Yasunami Saga-Ken Medical Centre Koseikan, Saga, Japan

Principal contribution of <em>HLA-DQ</em> alleles, <em>DQB1*06:04</em> and

<em>DQB1*03:01</em>, to disease resistance against primary biliary cholangitis in a Japanese

population

100172 1-C-W6-6-O/P Tomomi SatoDepartment of Fundamental Biosciences, Shiga University of Medical Science, Shiga,

Japan

Characterization of rheumatoid arthritis-associated interstitial pneumonia using collagen-induced

arthritis mice

100384 1-C-W6-7-O/P Kunihiro OtsukaDepartment of Oral Molecular Pathology, Institute of Biomedical Science, Tokushima

University Graduate School, Tokushima, JapanAnalysis of follicular helper T cells in a mouse model for Sj&ouml;gren&rsquo;s syndrome

100666 1-C-W6-8-P Kaieda Shinjiro Kurume university shcool of medicineInvolvement of CD163-positive Macrophages in the Pathogenesis of Arthritis via Modulation of

Inflammatory Cytokine Expression in the Synovium of a Murine Model

100545 1-C-W6-9-O/P Namiko OkabeDepartment of Rheumatology and Clinical Immunology, Graduate School of Medicine,

Kyoto University, Kyoto, JapanMyelin basic protein promotes experimental arthritis via non-T cells.

100231 1-C-W6-10-P Hayakawa KunihiroInstitute for Environmental and Gender Specific Medicine, Juntendo University

Graduate School of Medicine, Chiba, JapanPossible mechanisms of anti-arthritic effect induced by dietary &omega;-3 polyunsaturated fatty acids

100576 1-C-W6-11-O/P Soo-hyun ChungCenter for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo

University of Science, Noda, JapanTruncated glycan and C-type lectin ; a new therapeutic target for autoimmune arthriti

100479 1-D-W7-1-O/P Satoshi FukuyamaDivision of Virology, Department of Microbiology and Immunology, Institute of Medical

Science, University of Tokyo, Tokyo, JapanEffect of aging on the host response to avian influenza A(H7N9) virus infection in non-human primates

100431 1-D-W7-2-O/P Hiroshi UekiDivision of Virology, Department of Microbiology and Immunology, Institute of Medical

Science, University of TokyoVisualization of immune responses to influenza virus in mouse lung by using two-photon microscopy

100242 1-D-W7-3-O/P Natsuko Imakita Department of Immunology, Nara Medical University, Nara, JapanThe contribution of histone methyltransferase Setdb2 in the pathogenesis of influenza associated

encephalopathy

100116 1-D-W7-4-O/P Kayoko SatoInfluenza Virus Research Center, National Institute of Infectious Diseases, Tokyo,

Japan

TLR agonists enhance avidity and ADCC activities of virus-specific antibodies upon a booster

immunization of influenza vaccines

100102 1-D-W7-5-O/P Tatsuya YamazakiDepartment of Microbiology and Immunology, Aichi Medical University, School of

Medicine

<strong>Neutralizing anti-hemagglutinin IgG and IgA mAb induced by gene-base hydrodynamic

injection have a therapeutic effect in<u> upper respiratory influenza virus infection</u></strong>

100246 1-D-W7-6-O/P Masaaki OkamotoDepartment of Immunology, Graduate School of Medical Sciences, Kumamoto

University, Kumamoto, Japan

<strong>Circulating miR-451a in extracellular vesicles regulate innate immune cells response to

influenza A virus vaccine</strong>

100587 1-D-W7-7-O/P Takeharu MinamitaniLaboratory of Infectious Diseases and Immunity, National Institutes of Biomedical

Innovation, Health, and Nutrition, Ibaraki, Osaka, Japan

T cell and NK cell-mediated immune surveillance interferes with Epstein-Barr virus LMP-induced

lymphomagenesis in germinal center B cells

100266 1-D-W7-8-O/P Haruna OkudeLaboratory of Molecular Immunobiology, Nara Institute of Science and Technology,

Nara, JapanInduction of cell death by imiquimod (R837) and its role in immune responses

100066 1-D-W7-9-O/P Tomoko TakahashiDepartment of Biological Sciences, Graduate School of Science, The University of

Tokyo

LGP2 upregulates apoptosis-related genes by acting as an RNA silencing modulator during viral

infection

100226 1-D-W7-10-O/P Akihiko Komuro Niigata University of Pharmacy and Applied Life Sciences, Niigata, JapanA possible role of TAR-RNA binding protein phosphorylation in MDA5/LGP2-mediated cellular

responses by Cardiovirus infection

100013 1-D-W7-11-P Motomi Yamazaki Department of Gastroenterology, Nihon University School of Medicine Effects of H1N1 influenza virus infection on maternal and fetal in pregnant mouse

100265 1-D-W7-12-P Keiko NagataDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori

University, Yonago, Japan

ImmunoglobulinG4 production is induced by reactivation of Epstein-Barr virus persistent in B

lymphocytes from Graves&rsquo; disease patients and controls

100357 1-D-W7-13-P Yoshiko MurakataTsukuba Primate Research Center, National Institute of Biomedical Innovation, Ibaraki,

Japan

<strong>Studies of incomplete control of Epstein-Barr virus infection by using cynomolgus macaques

model.</strong>

100655 1-D-W7-14-P Toru Okamoto Research Institute for Microbial Diseases, Osaka University <strong>Selective TLR ligands stimulate <em>in vivo</em> pathogenicity of JEV</strong>

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Dec. 12 (Tue.),

2017

W7 Virus infection-1Dec. 12

(Tue.), 2017

W6Tissue-specific immune

diseases II

Dec. 12

(Tue.), 2017

W4

Endogenous innate

immunity and

inflammation-2

Dec. 12

(Tue.), 2017

W5Tissue-specific immune

diseases I

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(Tue.), 2017

2 / 13

Page 3: Session Title Date Time Submission ID Program No. 1st ... · The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster Session Title Date Time Submission ID

The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100053 1-D-W8-1-O/P Takayuki Chikata Center for AIDS Research, Kumamoto University, Kumamoto, Japan Control of HIV-1 by an HLA-B*52:01-HLA-C*12:02 protective haplotype

100313 1-D-W8-2-O/P Hayato Murakoshi Center for AIDS Research, Kumamoto University, Kumamoto, JapanImpact of a single escape mutation selected by HLA-A*24:02-restricted CD8<sup>+</sup> T cells on

HIV-1 control by HLA-B*35:01-restricted ones and T cell adaptation

100346 1-D-W8-3-O/P Chengcheng Zou Center for AIDS research, Kumamoto University, Kumamoto, Japan <strong>Conserved epitope-specific CTLs controlling HIV-1 replication</strong>

100177 1-D-W8-4-O/P Takamasa Ueno Center for AIDS Research, Kumamoto University, Kumamoto, Japan<strong>Relative resistance of MHC-B to Nef-mediated downregulation is conserved among primate

lentiviruses and correlates with reduced viral loads in HIV-1-infected individuals</strong>

100024 1-D-W8-5-O/P Eiji SHINYA Nippon Medical School, Tokyo, Japan

Hematopoietic cell kinase (Hck) augmented the interaction between HIV-1 Nef and SERINC5, which

might promote HIV-1 infection by excluding SERINC5 from virion incorporation in immature dendritic

cells

100210 1-D-W8-6-O/P Nami Iwamoto Immuno Technology Section, Vaccine Research Center, NIAID, NIHDevelopment of Chimeric Antigen Receptor (CAR)-Transduced CD8 T cells Using SIV-specific

Neutralizing Anibodies

100600 1-D-W8-7-O/P Daichi YamasobaLaboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences,

Kyoto University, Kyoto, JapanIdentification of a novel HIV-1 restriction factor which selectively degrades viral transcripts.

100263 1-D-W8-8-O/P Takuya SueyoshiLaboratory of Molecular Immunobiology, Graduate School of Biological Sciences, Nara

Institute of Science and Technology (NAIST), Nara, Japan

RNA-binding protein Hu antigen R (HuR) plays an important role in antiviral innate immune responses

via mRNA stabilization

100170 1-D-W8-9-O/P Takahisa KouwakiDepartment of Immunology, Graduate school of Medical Sciences, Faculty of Life

Sciences, Kumamoto University, Kumamoto, Japan

<strong>Zyxin</strong> <strong>is a positive factor in a MAVS/IPS-1-dependent

</strong><strong>type</strong> <strong>?</strong> <strong>interferon</strong> <strong>expression

pathway during viral infection.</strong>

100227 1-D-W8-10-P Yoshihiro Kumagai Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan

<strong>THE ANALYSIS OF THE INTERACTION BETWEEN HIV-1 GP 120 AND </strong><strong>b-

CHEMOKINE RECEPTOR BY USING MULITIVALENT V3 EPITOPES GRAFTED AT

IMMUNOGLOBULIN HYPERVARIABLE REGIONS </strong>

100261 1-D-W8-11-P Tomotaka OkamuraTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health

and Nutrition, Ibaraki Japan

Non-pathogenic AIDS virus carrying an adjuvant molecule induced strong cellular immunity and long-

term protective efficacy against pathogenic SHIV.

100454 1-D-W8-12-P Warunthorn MonwanLaboratry of Molecular Immunobiology, Graduate School of Biological Sciences, Nara

Institute of Science and Technology, Nara, JapanCharacterization of Nucleoporin (Nup) genes that mediate antimicrobial innate immune responses

100628 1-D-W8-13-P Kazuya TAKEDAFaculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi,

JapanTheiler&rsquo;s virus fails to stimulate plasmacytoid dendritic cell

100372 1-E-W9-1-O/P Takayuki Matsumura Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan<strong>Balance of pro- and anti-inflammatory cytokines in immature myeloid cells involved in outcome

of severe invasive group A <em>Streptococcus</em> infections</strong>

100080 1-E-W9-2-O/P Imai TakashiDivision of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University,

Fukuoka, Japan

<strong>Glycolipids in group A <em>Streptococcus </em>are recognized by Mincle to trigger host

immune responses</strong>

100136 1-E-W9-3-P Yukiko Akahori International University of Health and Welfare, Narita, Japan Dectin-1 mediates innate immune responses in <em>Streptococcus pneumoniae</em> infection

100383 1-E-W9-4-O/P Rin YokoyamaMedical Microbiology, Mycology and Immunology, Tohoku University Graduate School

of Medicine, Miyagi, Japan

<strong>Dectin-2-mediated signaling triggered by serotype 3 <em>Streptococcus pneumoniae

</em>and its contribution to host immune response</strong>

100491 1-E-W9-5-O/P Shogo Takatsuka Dept. Chemother. Mycoses, Nat. Inst. Infect. Dis.Follicular helper NKT cells augment germinal center B cell formation by a protein-based pneumococcal

vaccine

100490 1-E-W9-6-O/P Seitaro Nakagawa Department of Dermatology, Chiba University<em>Staphylococcus aureus </em>virulent PSM&alpha; peptides induce keratinocyte IL-1 and IL-36

release to orchestrate IL-17-dependent skin inflammation

100108 1-E-W9-7-P Krisana AsanoDepartment of Microbiology and Immunology, Hirosaki University Graduate School of

Medicine, Aomori, Japan

<strong>Establishment of a mouse uterine infection model of <em>Staphylococcus aureus </em>for

studying a role of toxic shock syndrome toxin-1</strong>

100359 1-E-W9-8-P Matsui KatsuhikoDepartment of Microbial Science and Host Defense, Meiji Pharmaceutical University,

Tokyo, Japan

<strong>Mast cells stimulated with peptidoglycan from <em>Staphylococcus aureus</em> enhance the

development of Th1 cells</strong>

100654 1-E-W9-9-P Arisa MorikawaDepartment of Molecular and Cellular Health Science, Graduate School of

Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan

Innate immune cells sense Staphylocuccus aureus-derived cysteine protease via their cell surface

molecule(s) to produce proinflammatory cytokines.

100422 1-E-W9-10-P Hiromi MiyazakiDivision of Traumatology, Research Institute, National Defense Medical College,

Tokorozawa, Japan

Coenzyme Q10 supplementation protects against methicillin-resistant Staphylococcus aureus infection

in burn-injured mice

100340 1-E-W9-11-O/P Nobuhiro Nakamoto Keio University School of Medicine, Tokyo, Japan<strong>Integrated collaboration of intestinal microbiota induces bacterial translocation and Th17

immune response in primary sclerosing cholangitis</strong>

100137 1-E-W9-12-P Shiho SuzukiDept Bacterial Infection and Host Responce, Tokyo Medical and Dental Univ (TMDU),

Tokyo, Japan

The microbial-host interactions that drive the activation of the Nlrc4 inflammasome in

<em>Shigella</em>-infected macrophages

100319 1-E-W9-13-P Yoshihiko Sugitani Department of Medicine, Shiga University of Medical Science, Otsu, Japan The therapeutic effects of elemental diet and intestnal microbiota

100079 1-E-W9-14-P Hideo NegishiDepartment of Molecular Immunology, Institute of Industrial Science, The University of

Tokyo, Tokyo, JapanIdentification and analysis of commensal bacteriophage in the intestine

100517 1-E-W9-15-O/P Ayako KaitaniAtopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo,

Japan

CD300f suppresses neutrophil recruitment to LPS-injected skin: A role of CD300f in gram-negative

bacterial skin infections

100656 1-E-W9-16-P Ryosuke Uchiyama Hyogo College of Medicine, Department of Microbiology, Nishinomiya, JapanInflammasome and Fas-mediated IL-1&beta; contributes to Th17/Th1 cell induction in pathogenic

bacterial infection

100046 1-E-W9-17-P Kazuhiro NegoroDepartment of Immunology, Institute of Advanced Medicine, Wakayama Medical

University, Wakayama, JapanAn Ets family member, Ets2 is required for Cholera toxin-induced arginase-1 gene expression

100093 1-E-W9-18-P Masanori IsekiDepartment of Immunology and Molecular Genetics, Kawasaki Medical School,

Kurashiki, JapanBST-1/CD157 on B cells negatively regulates Toll-like receptor signaling

100603 1-E-W10-1-O/P Ei'ichi IizasaDepartment of Immunology, Field of Infection and Immunity, Graduate School of

Medical and Dental Sciences, Kagoshima University, Kagoshima

Two ITAM-coupled receptors recognizing Mycobacterial mycolic acid-containing lipids and having the

different roles.

100577 1-E-W10-2-P Masayuki Umemura Tropical Biosphere Research Center, University of the Ryukyus, Okinawa, JapanInvolvement of IL-17A-producing TCR &gamma;&delta;<sup>+</sup> T cells in late protective

immunity against pulmonary <em>Mycobacterium tuberculosis </em>infection

100274 1-E-W10-3-O/P Naoto NouchiDivision of Host Defense, Medical Institute of Bioregulation, Kushu University, Fukuoka,

Japan

IL-21 signaling drives differentiation of short-lived effector CD8<sup>+</sup>T cells from early effector

cells but does not inhibit exhaustion following <em>Mycobacterium bovis</em> Bacillus Calmette-

Gu&eacute;rin infection in mice

100160 1-E-W10-4-O/P Shihoko Komine-Aizawa Nihon University School of Medicine, Tokyo, JapanInduction of CD8<sup>+</sup>- MHC-I-restricted, antigen-specific T cells by recombinant BCG

protects against mycobacterial infection

100283 1-E-W10-5-O/P Yusuke TsujimuraTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health

and Nutrition, Ibaraki, JapanThe immune responses induced by BCG vaccination in the non-human primate TB model

100250 1-E-W10-6-P Masahiro Kitabatake Department of Immunology, Nara Medical University, Nara, Japan<strong>CD8<sup>+</sup> T cells play a critical role for the murine model of immune reconstitution

inflammatory syndrome.</strong>

100144 1-E-W10-7-O/P Yasunobu MiyakeDivision of Molecular and Cellular Immunoscience, Department of Biomolecular

Sciences, Faculty of Medicine, Saga University, Saga, Japan

Immunosuppressive receptor, Siglec binds to pathogenic fungus, <em>Trichophyton

mentagrophytes</em>, and negatively regulates host immune responses

100304 1-E-W10-8-O/P Daiki TannoDepartment of Medical Microbiology, Mycology and Immunology, Tohoku University

Graduate School of Medicine

Dectin-2-mediated signaling triggered by the cell wall structures of <em>Cryptococcus

neoformans</em>

100378 1-E-W10-9-P Yuki KITAIMedical Microbiology, Mycology and immunology, Tohoku University Graduate School

of Medicine

<strong>Involvement of Dectin-2 in the recognition and phagocytosis of

</strong><em><strong>Cryptococcus neoformans </strong></em><strong>by dendritic cells</strong>

100329 1-E-W10-10-P Kotone KawamuraDepartment of Medical Microbiology, Mycology and Immunology, Tohoku University

Graduate School of Medicine, Miyagi, japan

Activation of Dectin-2-mediated signaling by cryptococcal capsular polysaccharides: Comparison

between <em>Cryptococcus neoformans</em> and <em>C. gattii</em>

100579 1-E-W10-11-P Yuki SATOMedical Microbiology, Mycology and Immunology, Tohoku University Graduate School

of Medicine, Miyagi, Japan

Effect of Mincle-deficiency on the host immune response against <em>Cryptococcus neoformans</em>

infection

100458 1-E-W10-12-O/P Keigo UenoDepartment of Chemotherapy and Mycoses, National Institute of Infectious Diseases,

Tokyo, Japan

Dendritic cell-based vaccination induces lung resident memory Th17 cells that ameliorate pulmonary

infection with highly virulent <em>Cryptococcus gattii</em>

100121 1-E-W10-13-P Sonoko TasakiSection of Infection Biology, Department of Functional Biosciences, Fukuoka Dental

College.Investigation of mechanisms underlying the T cell response in oral candidasis.

100345 1-F-W11-1-P Matsuoka Shuji Department of Patology and Oncology Juntendo University School of Medicine Anapocosis: Direct cell death of lymphoma cells induced by mAbs.

100228 1-F-W11-2-P Ouji-Sageshima Noriko Department of Immunology, Nara Medical University, Kashihara, Japan The critical role of HLA class Ib proteins, HLA-E and HLA-F, expressed on tumor cells

100044 1-F-W11-3-O/P Naoto NishiiDepartment of Molecular Immunology, Graduate School, Tokyo Medical and Dental

University

Systemic administration of low dose TLR7 agonist augments antitumor responses in the PD-1

checkpoint blockade-resistant and regulatory T cell-dominant murine tumor models

100565 1-F-W11-4-O/P Shime HiroakiDepartment of Immunology,?Nagoya City University Graduate School of Medical

Sciences, Nagoya, Japan

Toll-like receptor 2 ligand and interferon-&gamma; suppress anti-tumor T cell responses by enhancing

the immunosuppressive activity of monocytic myeloid-derived suppressor cells

100182 1-F-W11-5-P Etsuko Harada Department of Immunology, Mie University School of Medicine, Mie, Japan<strong><em>Agaricus blazei</em></strong><strong> Murrill extract inhibits</strong><strong> the

expression of immune checkpoint molecules in a lung cancer cell line</strong>

100373 1-F-W11-6-P Shota Kajiyama Kobayashi Pharmaceutical Co., Ltd., Osaka, JapanInvestigation of the effect of a combination of immune checkpoint inhibitor and Lentinula Edodes

Mycelia (L.E.M.) extract on antitumor response in CT26 colon carcinoma-bearing mice.

100375 1-F-W11-7-O/P Nobuo TsukamotoDivision of cellular Signaling, Institute for Advanced Medical Research, Keio University

School of Medicine, Tokyo, Japan

Berberine augments tumor antigen specific T cells <em>in vivo</em> through metabolic remodeling in

CD8<sup>+</sup> T cells in tumors and lymph nodes

100371 1-F-W11-8-O/P Alok KumarDepartment of Immunology and Genomic Medicine, Graduate School of Medicine,

Kyoto University, Kyoto, Japan

<strong>Indicators of mitochondrial activation in T cells could be a biomarker to predict the PD-1

blockade therapeutic efficacy.</strong>

100617 1-F-W11-9-O/P kagawa MasakiDivision of Cellular Signaling Institute, for Advanced Medical Research, Keio University

School of Medicine

Immunomodulation of ovarian clear cell carcinoma by targeting HNF-1&beta;-NF-kB-IL6 pathway

enhances anti-tumor immunity

100669 1-F-W11-10-P Takuma ISSHIKI Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan Anti-TIM-3 treatment exacerbates pulmonary inflammation and fibrosis in mice

100409 1-F-W11-11-O/P Chang-Yu ChenDepartment of Molecular Preventive Medicine, Graduate School of Medicine, The

University of Tokyo, Tokyo, Japan

<strong>Low-dose HMGN1 synergistically enhances anti-tumor immunity in CD4 depleting antibody-

treated mice</strong>

100393 1-F-W11-12-O/P Nanumi HanDivision of Immunobiology, Institute for Genetic Medicine, Hokkaido University,

Sapporo, Japan

<strong>Identification of factors that affect myeloid cells in immunotherapeutic-resistant

tumors</strong>

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W11

Combination cancer

immunothrapy -beyond

immune checkpoint

inhibitors-

Dec. 12

(Tue.), 2017

W9Immune response to

bacteial infections

Dec. 12

(Tue.), 2017

W10

Immune response to

mycobacteial and fungal

infections

Dec. 12

(Tue.), 2017

W8 Virus infection-2Dec. 12

(Tue.), 2017

3 / 13

Page 4: Session Title Date Time Submission ID Program No. 1st ... · The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster Session Title Date Time Submission ID

The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100365 1-F-W12-1-O/P Hirohito Ishigaki Department of Pathology, Shiga University of Medical Science, Otsu, Japan,<strong>The hemoperfusion column removing LAP positive cells activates the tumor-specific immunity

in a cynomolgus monkey</strong>

100087 1-F-W12-2-O/P Harada Michishige RIKEN Center for Integrative Medical Science (IMS)CD81 is associated with non-apoptotic cell death in B cell lymphoma cell lines through HLA-

DR&alpha;/&beta; engagement

100176 1-F-W12-3-P Makoto KuboDivision of Immunology, Kitasato University School of Allied Health Sciences,

Kanagawa, Japan

Analysis of immune responses in prostate cancer patients received iridium-192 high-dose-rate prostate

brachytherapy

100285 1-F-W12-4-O/P Takeshi Yamada System Biology,Kanazawa university,Kanazawa,Japan<strong>Features of immune response induced </strong><strong>by </strong><strong>Gemcitabine in

</strong><strong>pancreatic ductal adenocarcinoma</strong> <strong>model</strong>

100350 1-F-W12-5-P Erica YADADepartment of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute,

Kanagawa, Japan

Next-generation sequencing analysis of gemcitabine (GEM) resistant mechanism using patient-derived

xenograft (PDX) model in pancreatic cancer

100192 1-F-W12-6-O/P Kikuya SugiuraDepartment of Advanced Pathobiology, Graduate School of Life and Environmental

Sciences, Osaka Prefecture University, Izumisano, Japan

Manipulation of tumor microenvironment by cytokine gene transfection enhances dendritic cell-based

immunotherapy

100200 1-F-W12-7-P Mariko TakamiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University,

Chiba, JapanAhR signaling enhances the moDC function to activate NKT cells

100259 1-F-W12-8-P Kazuki MisatoVaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories,

Research Institute for Microbial Diseases, Osaka UniversityDevelopment of a cancer vaccine by using dendritic cell-targeting peptide

100358 1-F-W12-9-P Shunsuke TakeseDepartment of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical

Sciences, Tokushima University, Tokushima, JapanThe combined effect of liposomal oxaliplatin with cancer vaccine on anticancer therapy.

100352 1-F-W12-10-O/P Yoshino TanakaDivision of Immunobiology, Institute for Genetic Medicine, Hokkaido University,

Sapporo, JapanDying but not dead cancer cells exert the effect of cell-based cancer vaccine

100335 1-F-W12-11-P Kaori Denda-NagaiDivision of Glycobiologics, Intractable Research Center, Juntendo University Graduate

School of Medicine, Tokyo, Japan

Difference in humoral immune response after immunization with glycosylated MUC1 between C57BL/6

mice and MUC1 transgenic mice

100224 1-F-W12-12-O/P Serina TokitaDepartment of Pathology, Sapporo Medical University School of Medicine, Sapporo,

JapanHLA-A24 ligandome analysis identifies a neoantigen that elicits strong CTL responses

100026 1-G-W13-1-P Ikuo NobuhisaDepartment of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and

Dental University (TMDU), Tokyo, Japan

Role of adhesion molecules induced by a transcription factor Sox17 in intra-aortic hematopoietic cell

cluster formation in midgestation mouse embryos

100497 1-G-W13-2-P Eriko Sumiya Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan Fate mapping of RANKL-expressing cells in the fetal bone

100254 1-G-W13-3-P Takahiro NoguchiDepartment of Immunology and Cell Biology, Osaka University Graduate School of

Medicine, Osaka, JapanDynamic analysis of hematopoietic stem cells in vivo by using intravital imaging techniques

100109 1-G-W13-4-O/P Takao SudoDepartment of Immunology and Cell Biology, Osaka University Graduate School of

Medicine, Osaka, JapanStressed microenvironment induced by 5-FU promotes the proliferation of HSPC in bone marrow

100324 1-G-W13-5-P Yoshikazu HayashiInternational Research Center for Medical Sciences, Kumamoto University, Kumamoto,

Japan<strong>Impact of inflammatory stress on early hematopoiesis</strong>

100496 1-G-W13-6-O/P Yukiko DoiDepartment of Hematology and Oncology, Osaka University Graduate School of

Medicine, Suita, Osaka, Japan

SATB1 expression is useful to identify the lymphoid-lineage-biased trajectory of functionally fluctuating

hematopoietic stem cells.

100312 1-G-W13-7-O/P Junichiro TakanoLaboratory for Immune Regeneration, RIKEN Center for Integrative Medical Sciences,

Yokohama, Japan

<strong>Varinat PRC1.1 is required for specification of hematopoietic progenitor cells toward B

lymphoid lineage</strong>

100204 1-G-W13-8-O/P Yohei KawanoDepartment of Immune Regulation, Tokyo Medical and Dental Universiy Graduate

School, Tokyo, Japan

Establishment of a novel culture system for long-term proliferating hematopoietic progenitors with

lymphoid and myeloid potential from normal mouse bone marrow without genetic manipulations

100551 1-G-W13-9-O/P Tatsuya ShishidoDepartment of Immunochemistry, Research Institute for Microbital Disease, Osaka

UniversityCrucial role of CD74 in hematopoietic cell differentiation

100336 1-G-W13-10-O/P Masashi KanayamaDepartment of Immunology, Duke University School of Medicine, Durham, North

Carolina, USA.Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms

100229 1-G-W13-11-P Akihisa Oda Chiba, Japan<strong>Niche-induced myeloproliferative-like disease caused by overexpression of Tlx1 i<em>n situ

</em>in splenic stromal cells</strong>

100241 1-G-W13-12-O/P Akihisa Oda Research Institute for Biomedical Sciences Tokyo Universitiy of Science, Chiba, Japan<strong>Niche-induced myeloproliferative-like disease caused by overexpression of Tlx1 i<em>n situ

</em>in splenic stromal cells</strong>

100244 1-G-W13-13-P Ueno YutaLaboratory of Molecular Biology and Immunology, Department of Biological Science

and Technology, Tokyo University of Science

<strong>Two mesenchymal progenitor cell populations in the spleen defined by a novel three-

dimensional culture system</strong>

100540 1-G-W13-14-P Toshiki TezukaDivision of Development and Aging, Research Institute for Biomedical Sciences, Tokyo

University of Science, Chiba, Japan

Defects in splenic architectural organization by postnatal deletion of the gene encoding a transcription

factor Tlx1 in spleen mesenchymal cells

100124 1-G-W13-15-P Krutula Nair RIKEN Center for Integrative Medical Sciences, Yokohama, Japan A ThPOK-independent CD4-skewed differentiation by loss of Tet proteins and SATB1

100097 1-G-W13-16-O/P Yasuyuki SaitoDivision of Molecular and Cellular Signaling, Department of Biochemistry and

Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan

SIRP&alpha;<sup>+</sup> dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF

receptor ligands in the adult spleen

100367 1-G-W13-17-O/P Kazuki Sato Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan Marginal reticular cells act as a non-professional phagocyte for clearance of apoptotic B cells

100302 1-G-W13-18-O/P Arata TakeuchiDepartment of Immunology, Graduate School of Medical and Dental Sciences, Niigata

University, Niigata, Japan

Six different types of mesenchymal stromal cells provide the framework of multi-layered

subcompartments in lymph node

100498 1-G-W13-19-P Satomi KomoriDivision of Molecular and Cellular Signaling, Department of Biochemistry and

Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan

<strong>Development of a novel primary culture system for lymphoid organ fibroblastic reticular

cells</strong>

100438 1-G-W13-20-P Yasuhiro KandaDepartment of Immunology and Medical Zoology, Niigata University Graduate School

of Medical and Dectal sciencesLive imaging of the allogeneic T cell elimination in secondary lymphoid organs

100512 1-G-W13-21-P Yoshihiro Ueda Molecular Genetics, Institute of Biomedical Science, Kansai Medical University<strong>Regulation of cell polarization by Rap1 via NDR/Rab8 axis upon chemokine

stimulation</strong>

100567 1-G-W13-22-P Toshihiro Komatsu Department of Immunology, School of Medicine, Kochi University, Kochi, JapanExtravasation of CTLs occurs by recognizing the MHC-peptide complexes cross-presented by vascular

endothelial cells.

100568 1-G-W13-23-P Junya Ohtake Cancer Vaccine Center, Kanagawa Cancer Center, Yokohama, Japan <strong>Comprehensive analysis of immunological tumor environment in colorectal cancer</strong>

100347 1-H-W15-1-O/P Kentaro Asayama Dept of Immunology<strong>A novel mouse model of spontaneous lung cancer caused by lung TGF-&beta;1

overexpression</strong>

100483 1-H-W15-2-O/P Mayu Kaetsu Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan Colonic inflammation induces a transient increase in serum LECT2 level.

100411 1-H-W15-3-O/P Wooseok Seo RIKEN IMS Center for Integrative Medical Sciences,Yokohama, Japan Regulation of CCL5 expression by Runx complexes and two stage-specific enhancers

100508 1-H-W15-4-O/P Sunyi JooDivision of Mucosal Immunology, Department of Microbiology and Immunology, The

Institute of Medical Science, The University of Tokyo, Japan

<strong>Critical role of the CCR5-CCL5 cascade for the preferential migration of HSV-2-specific

effector cells to the vaginal mucosa upon intranasal immunization </strong>

100107 1-H-W15-5-O/P Mizuho Nosaka Department of Forensic Medicine, Wakayama Medical University, Wakayama, JapanAbsence of CCR5 axis exaggerates thrombus formation through reduced uPA, tPA and VEGF

expression in murine DVT mode

100061 1-H-W15-6-O/P Masaaki KawanoDepartment of Allergy and Immunology, Faculty of Medicine, Saitama Medical

University, Saitama, Japan<strong>Dopamine fluctuates cytokine secretion in innate and adaptive immune responses</strong>

100150 1-H-W15-7-O/P Keiko YoshimotoDivision of Rheumatology, Department of Internal Medicine, Keio University School of

Medicine, Tokyo, Japan

BAFF signaling inhibitors ameliorate enhanced production of IL-6 and IL-10 by pSS monocytes and

consequently suppress IgG overproduction by affecting differentiation of B cells.

100309 1-H-W15-8-O/P Mizoguchi IzuruDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical

University, Tokyo, Japan

<strong>A Novel Role for Epstein-Barr Virus-Induced Gene 3 to Augment IL-23 Receptor

</strong><strong>&alpha;</strong> <strong>Protein Expression through A Lectin Chaperone Calnexin

</strong>

100625 1-H-W15-9-O/P Hironao SuzukiDivision of Psychoimmunology, Institute for Genetic Medicine, Hokkaido University,

Hokkaido, Japan

<strong>RNA Splicing Mediator 1 (RSM1) regulates inflammation via alternative splicing of DNA

methyltransferase Dnmt3b</strong>

100115 1-H-W15-10-P Takehiko Shibata Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan The role of RSV-induced Gas6/Axl signaling in secondary bacterial infection.

100161 1-H-W15-11-P Yuji TakedaDepartment of Immunology, Yamagata University Faculty of Medicine, Yamagata,

Japan

Analysis of cytokine signals using flow cytometry is useful for detection of contractive and fluctuating

signals.

100193 1-H-W15-12-P YAMAMOTO Shinya Division of Chemotherapy, Kindai University Faculty of Pharmacy, Osaka, Japan

A highly active form of lymphotactin/XCL1 (XCL1-CC3) functions as a potent adjuvant to accumulate

CD103+XCR1+ cross-presenting dendritic cells and induce CD8+ CTL-mediated antitumor and

antiviral effects

100195 1-H-W15-13-P KAMBARA Hirokazu Division of Chemotherapy, Kindai University Faculty of Pharmacy, Osaka, Japan CCL28-deficiency altered microbiota in the colon and aggravated DSS-induced colitis in mice

100197 1-H-W15-14-P MATSUO Kazuhiko Division of Chemotherapy, Kindai University Faculty of Pharmacy, Osaka, JapanCCR4 is involved in atopic dermatitis-like skin lesions induced by topical sensitization of ovalbumin and

&delta;-toxin using a hydrogel patch in mice

100397 1-H-W15-15-P Hiroki TanakaWorld Premier Institute Immunology Frontier Research Center (WPI-IFReC), Osaka

University, Osaka, Japan

Regnase-1 phosphorylation induced by proinflammatory cytokines controls stability of its target

mRNAs.

100611 1-H-W15-16-P Numasaki Muneo Tohoku University Hospital, Sendai, Japan IL-32 promotes the cell growth of malignant methothelioma

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2017

W13Hematopoiesis and

immune environments

Dec. 12

(Tue.), 2017

W15Cytokines and

chemokines-1

Dec. 12

(Tue.), 2017

W12Immune responses in

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Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100534 1-H-W16-1-O/P Kazuo OkamotoDepartment of Osteoimmunology, Graduate School of Medicine and Faculty of

Medicine, The University of Tokyo, Tokyo, JapanA distinct role of an EF-hand motif protein in the hematopoietic cell lineage

100279 1-H-W16-2-O/P Koki HirashimaDepartment of immunology, Graduate School of Pharmaceutical Sciences, Hokkaido

University<strong>Tyk2 positively regulates <em>P. acnes</em>-induced acute inflammation</strong>

100007 1-H-W16-3-O/P Takashi IzawaDepartment of Orthodontics and Dentofacial Orthopedics, Tokushima University

Graduate School of Biomedical Sciences, Tokushima, JapanCrosstalk between cytokine RANKL and AhR signaling in osteoclasts controls bone homeostasis

100146 1-H-W16-4-O/P Yurina Miyajima Laboratory for Innate Immune Systems, RIKEN IMS Function of BMP2 and BMP7 produced by ILC2 in the adipose tissue

100308 1-H-W16-5-O/P Ippei KoshiDepartment of Molecular and Cellular Immunology, Shinshu University Graduate

School of Medicine

Branching cytokine signals for an effector function and cell survival via a discrete common &beta; chain

subregion in murine primary basophils

100318 1-H-W16-6-O/P Yuki Hikichi Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences Post-transcriptional regulation of type 2 cytokine gene expression in ILC2

100663 1-H-W16-7-O/P Natsuo Yamamoto Department of Infection Control Anti-inflammatory effects on liver cells with flavonoids during rapid phgase in a severe sepsis

100477 1-H-W16-8-O/P Jae-won Chang Graduate School of Frontier Sciences, The University of Tokyo, Chiba, JapanThe first distinction and observation of single molecular dynamics between Interleukin-2 with

Intereleukin-2 receptor and Interleukin-15 with Interleukin-15 receptor through Diffracted X-ray Tracking

100104 1-H-W16-9-O/P Kazuko Uno Louis Pasteur Center for Medical ResearchUsing non-negative matrix factorization analysis of IFN/Cytokine production and those of serum levels

to identify groups at high-risk of disease or those in the early stages of disease

100016 1-H-W16-10-P Munehiro YamaguchiDepartment of Internal Medicine, Division of Allergology and Respiratory Medicine,

School of Medicine, Showa University, Tokyo, JapanIL-34 induces lung fibrosis via M2 macrophages differentiation in mouse lung injured model

100045 1-H-W16-11-P Izumi SasakiDepartment of Immunology, Institute of Advanced Medicine, Wakayama Medical

University, Wakayama, JapanRoles of arginine and methionine metabolism in cholera toxin-induced adjuvant effects

100105 1-H-W16-12-P Toshikazu Kondo Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan The absence of CCL3 exaggerates CaCl<sub>2</sub>-induced aortic aneurysm

100141 1-H-W16-13-P Yasu-Taka AzumaLaboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka

Prefecture University Graduate School of Life and Environmental Science, Izumisano,

Japan

Exacerbated TNBS-induced colitis in interleukin-19 knockout mice

100165 1-H-W16-14-P Kyosuke Kanai Department of Virology, Tottori University Faculty of Medicine, Yonago, Japan Role of IL-35 in Lipopolysaccharide-Induced Airway Eosinophilia

100463 1-H-W16-15-P Riyoko TamaiDepartment of Oral Medical Science, Ohu University School of Dentistry, Fukushima,

JapanAlendronate induces caspases-independent cell death via NLRP3 and ASC

100591 1-H-W16-16-P Kei MatsunoDepartment of Respiratory Medicine, Juntendo University School of Medicine, Tokyo,

Japan

TWEAK enhances epithelial mesenchymal transition and chemokine production in human bronchial

epithelial cells

100010 1-I-W17-1-O/P Yuki HitomiDepartment of Human Genetics, Graduate School of Medicine, the University of Tokyo,

Tokyo Japan

Identification of the disease causal variants in human primary biliary cholangitis (PBC) susceptibility

gene loci <em>NFKB1/MANBA</em>

100668 1-I-W17-2-P Saeko Shimodera Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, JapanA first case of hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by a large

<em>UNC13D</em> gene duplication

100297 1-I-W17-3-O/P Ryutaro IWABUCHI Department of Life Science and Medical Bioscience, Waseda University, Tokyo, JapanHuman GM-CSF and Flt3-L induce reconstitution and maturation of human myeloid dendritic cells in

humanized mice

100412 1-I-W17-4-P Yusuke OhnoDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara,

Japan<strong>Pregnant humanized mouse as a model of human pregnant immunity</strong>

100440 1-I-W17-5-P Asami Hanazawa Central Institute for Experimental Animals, Kawasaki, Japan<strong>NOG human M-CSF transgenic mice enhance differentiation and maturation of human

monocytes and macrophages</strong>

100445 1-I-W17-6-P Ikumi Katano Central Institute for Experimental Animals, Kawasaki, JapanHuman macrophages which developed into NOG-human GM-CSF/IL-3 Tg mice after hematopoietic

stem cells phagocytosed mouse erythrocytes and induced serious anemia.

100011 1-I-W17-7-P Tomonori HayashiDepartment of Molecular Biosciences, Radiation Effects Research Foundation,

Hiroshima, Japan

<strong>Relationship between T-cell Frequencies before Vaccination, Cytokine Levels, and Influenza

Vaccine Response</strong>

100111 1-I-W17-8-P Segawa Seiji Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan. The analysis of placenta specific 8 in monocytes from Adult Still&rsquo;s disease

100466 1-I-W17-9-P Kohsuke IMAI Department of pediatrics, Tokyo Medical and Dental University, Tokyo, Japan Diagnostic method for primary immunodeficiency using spectral flow cytometry

100525 1-I-W17-10-P JeongHoon Park Department of Immunopathology, IFReC, Osaka University, Osaka, Japan<strong>Study of Human Autoimmune Diseases Enabled by Gene Editing in Reporter Cell

Lines</strong>

100526 1-I-W17-11-P Yuka KobayashiLaboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto

University, Kyoto, JapanThe construction and application of human-type artificial lymphoid tissues

100569 1-I-W17-12-P Hirofumi Shibata Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, JapanA novel human Cytotoxic Lymphocyte-based functional assays for primary hemophagocytic

lymphohistiocytosis

100643 1-I-W17-13-O/P Fumiko HONDA-OZAKICenter for Stem Cell Biology and Regenerative Medicine Institute of Medical Science

University of Tokyo

Evaluation of the Utility of Induced Pluripotent Stem Cells as a platform for modeling Wiskott Aldrich

Syndrome

100180 1-I-W17-14-O/P Daisuke SUZUKI Center for iPS Cell Research and Application, Kyoto University, Kyoto, JapanDifferential natural killer (NK) cell immunity against class-I human leukocyte antigen (HLA)-knockout

(KO) platelets and megakaryocytes

100154 1-I-W17-15-O/P Iwamoto SanjuDivision of Physiology and Pathology, Department of Pharmacology, Toxicology and

Therapeutics, Showa University of Pharmacy, Tokyo, JapanAtypical development of human Th17 lineage from na&iuml;ve CD4 T cells in psoriasis.

100278 1-I-W17-16-O/P Nozomi Kuse Center for AIDS Research, Kumamoto University, Kumamoto, Japan<strong>Effective priming of functional HIV-1-specific CD8<sup>+</sup> T Cells from na&iuml;ve T

cells using STING ligand</strong>

100398 1-I-W17-17-P Kaori HayashiDepartment of Obstetrics and Gynecology, Shiga University of Medical Science, Otsu,

JapanEfficacy of spontaneous occurring endometriosis by extracorporeal circulation in cynomolgus monkey

100403 1-I-W17-18-O/P Iyoda Tomonori RIKEN Center for Integrative Medical Sciences, Yokohama, JapanImprovement of NK cell function against multiple myeloma cells by an adjunctive effect of activated

invariant natural killer T (NKT) cells

100532 1-I-W17-19-P Atsushi KadowakiNational Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo,

Japan

CCR9+ CD4+ memory T cells dependent on gut microbiota and age are altered in secondary

progressive multiple sclerosis

100548 1-I-W17-20-P Morita KentaroDepartment of Immunology and Parasitology, School of Medicine, University of

Occupational and Environmental Health, Japan, Kitakyushu, Japan

Effect of triterpenoid anticancer drug CuD on peripheral blood lymphocytes from a patient with

recurrent ATLL

100627 1-I-W17-21-P Shimizu Mikito Osaka University, Osaka, JapanFebuxostat Ameliorates Secondary Progressive Experimental Autoimmune Encephalomyelitis by

Restoring Mitochondrial Energy Production in a GOT2-dependent Manner

100631 1-I-W17-22-P Hiroyuki Yoshitomi Institute for Frontier Life and Medical Sciences、Kyoto University, Kyoto, JapanTranscriptional regulation of PD-1<sup>+</sup>CD4<sup>+</sup>T cells under inflammatory

conditions

100662 1-I-W17-23-O/P Kayoko Sato Department of Cardiology, Tokyo Women's Medical University, Tokyo, JapanDipeptidyl peptidase 4 (DPP-4) signaling in T cells contributes atherosclerotic development and

podocyte dysfunction

100042 1-I-W18-1-O/P Soh Yamazaki Department of Biochemistry, Toho University School of Medicine The AP-1 transcription factor JunB is essential for development of Th17 cells

100082 1-I-W18-2-O/P SHINYA TANAKA Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan<strong>Tripartite motif-containing 33 (Trim33) mediates a pro-inflammatory phenotype of Th17

cells.</strong>

100620 1-I-W18-3-O/P Keiko YasudaLaboratory of Experimental Immunology, Institute for Frontier Life and Medical

Sciences, Kyoto University, Kyoto, JapanSatb1 controls the differentiation and terminal effector function of Th17 cells

100207 1-I-W18-4-O/P Yuko OkuyamaDepartment of Microbiology and Immunology, Tohoku University Graduate School of

Medicine, Miyagi, Japan

A new regulator of OX40 co-signaling controls autoimmune neuroinflammation mediated by

CD4<sup>+</sup> T cells

100135 1-I-W18-5-P Kyoko NISHIDADepartment of Immunology and Pathology, National Center for Global Health and

Medicine

NQO1 play a pathogenic role in autoimmune diseases through the suppression of IL-10 production in

Th17 cells

100173 1-I-W18-6-P Nobumasa Watanabe Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan MHC-II-dependent autonomous immune responses of in vitro-differentiated Th17 cells

100009 1-I-W18-7-O/P Kota KokuboDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba,

Japan

<strong>Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2

cells.</strong>

100320 1-I-W18-8-O/P Makoto KuwaharaDepartment of Immunology, Graduate School of Medicine, Ehime University, Ehime,

JapanThe transcriptional repressor Bach2 regulates differentiation of pathogenic Th2 cells

100543 1-I-W18-9-O/P Harada Yasuyo Research Institute for Biomedical Science, Tokyo University of Science, Chiba, Japan<strong>Role of follicular helper T cells and TH2 cells in IgE mediated </strong><strong>active

cutaneous anaphylaxis</strong>

100413 1-I-W18-10-O/P Masaki Tajima Laboratory of Host Defenses, NIAID, NIH, Maryland, USA<strong>IL-10-Producing Tr2 cells Induced by mTOR/CEBP&beta; Signaling Regulate Hyphal <em>C.

albicans</em> Kidney Infection</strong>

100444 1-I-W18-11-P Tomo Takebe Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan A novel mouse model for tracking the fate of follicular helper T cells

100513 1-I-W18-12-P Kazuki Sakamoto Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan Dysregulation of humoral immunity in Foxp3 conditional knockout mice

100376 1-I-W18-13-P Shojiro IkezakiSection of Infection Biology, Department of Functional Bioscience, Fukuoka Dental

Collage.

A novel alternative splicing of T-cell signaling molecule modulates TCR-mediated responses in Th2

cells

100547 1-I-W18-14-P Yuriko TanakaDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo,

JapanThe presence of T cells with both Th1 and Th2 characteristics in mice

100333 1-I-W18-15-P Akiho OniyamaMedical Microbiology, Mycology and Immunology, Tohoku University Graduate School

of Medicine, Miyagi, Japan

Immunological analysis of the mechanism for higher virulence of <em>Cryptococcus gattii</em>

infection using a transgenic mouse expressing T cell antigen receptor for 98 kDa mannoprotein

100088 1-I-W18-16-P Izumi KurataDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine,

University of Tsukuba, Tsukuba, Japan

The Role of Follicular Helper 17 T cells and Desialylation of Autoantibody in Glucose-6-phosphate

Isomerase Induced Arthritis

100063 1-I-W18-17-P Shunta KanekoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki,

Japan.

The RORgt-CCR6-CCL20 axis enhances Th17 cells invasion into the synovia of patients in rheumatoid

arthritis

100294 1-I-W18-18-P Hayato YabeResearch Institute for Frontier Medicine , Sapporo Medical University School of

Medicine , Hokkaido , JapanRegulatory mechanisms of the production of IgG4 in IgG4-related dacryoadenitis and sialadenitis

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W17 Human ImmunologyDec. 12

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The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100179 2-A-W19-1-P Jianshi Jin RIKEN Quantitative Biology Center (QBiC), Osaka, JapanA novel high-throughput method for bacteria counting based on <em>de-novo</em> 16S rRNA

sequence identification with single-base resolution

100118 2-A-W19-2-P Siddhika PareekLaboratory of Immune Regulation, Graduate School of Medicine, Osaka University,

Osaka, Japan

<strong>Comparative analysis of gut microbiome diversity between Japanese and Indian cohorts

exhibits a diet-dependent synergism between bacteria and fungi</strong>

100381 2-A-W19-3-O/P Daisuke Takahashi Keio University Faculty of Pharmacy, Tokyo, Japan Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.

100162 2-A-W19-4-P Masahisa Hemmi Graduate School of Pharmaceutical Sciences, Osaka University,Osaka, JapanTh17 promotes the induction of antigen-specific gut-mucosal CTLs following intramuscular vaccination

of an adenovirus vector

100499 2-A-W19-5-O/P Kiyoshi Hirahara Department of Immunology, Graduate School of Medicine, Chiba UniversityMemory-type ST2<sup>+</sup>CD4<sup>+</sup> T cells participate in the steroid-resistant pathology

of eosinophilic pneumonia

100169 2-A-W19-6-P Ito SayamiProject for Vaccine and Immune Regulation, Graduate School of Pharmaceutical

Sciences, Osaka University

Elucidation of the induction mechanism of transcutaneous immune responses with the self-dissolving

microneedle patch

100306 2-A-W19-7-P Kanae NiimiInternational Education and Research Center for Food and Agricultural Immunology,

Graduate School of Agricultural Science, Tohoku University, Miyagi, JapanDevelopment of immune and microbial environments is independently regulated in the mammary gland

100117 2-A-W19-8-O/P Takahiro NagatakeLaboratory of Vaccine Materials and Laboratory of Gut Environmental System, National

Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan

17,18-EpETE, a metabolite of omega-3 essential fatty acids, inhibited neutrophil mobility and

ameliorated skin inflammation in DNFB-induced contact hypersensitivity model

100258 2-A-W19-9-O/P Emi FurusawaDepartment of Molecular Immunology , Tokyo Medical and Dental

University,Tokyo,JapanSilencing of B7-DC/PD-L2 in the cutaneous dendritic cells using siRNA inhibits contact allergy

100419 2-A-W19-10-P Daisuke TAKABAYASHI Narashino, Chiba , Japan Roles of MGL2 positive DC and Basophil on type 2 Contact Hypersensitivity model mice.

100090 2-A-W19-11-O/P Tomohiro FUKAYADivision of Immunology, Department of Infectious Diseases, Faculty of Medicine,

University of MiyazakiCritical role of IL-22 binding protein in the control of skin inflammation

100282 2-A-W19-12-P Ryuta Muromoto Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, JapanBasal STAT3 activity maintained by TYK2 is required for IL-17-induced I&kappa;B-&zeta; expression in

keratinocytes

100257 2-A-W19-13-P Airi MasakiDepartment of Plastic and Reconstructive Surgery, Tohoku University school, Miyagi,

JapanCritical role of interferon (IFN) - &gamma; in the skin wound healing

100264 2-A-W19-14-O/P Mari TennoDepartment of Immune Regulation Research Institute National Center for Global

Health and Medicine, Chiba, JapanDisruption of Lnk increases severity of dextran sulfate sodium-induced acute colonic inflammation

100085 2-A-W19-15-P Kazuaki Nakata College of Bioresource Sciences, Nihon University, Kanagawa, Japan miR-21-5p regulates intestinal epithelial permeability through ADP-ribosylation factor 4 (ARF4)

100128 2-A-W19-16-O/P Yuki Usui Division of Systems Immunology, Institute of Medical Science, The University of Tokyo <strong>Maintenance of intestinal barrier function by long-term intake of LB81 yogurt</strong>

100067 2-A-W19-17-O/P Chiao-Ching HsuLaboratory of Immune Regulation, Graduate School of Medicine, Osaka University,

Japan

<strong>Human LYPD8 protein has motility inhibitory functions to pathogenic flagellated

bacteria</strong>

100280 2-A-W19-18-P Atsushi Nishida Shiga University of Medical Science, Otsu, Japan Expression of Human Cathelicidin Peptide LL-37 in Inflammatory Bowel Disease

100034 2-B-W20-1-O/P Sumie HiramatsuDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama

University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,

Okayama, Japan.

DNA Methylation-dependent regulation of Cathepsin E gene expression by the transcription factor

Kaiso in MRL/lpr mice.

100012 2-B-W20-2-O/P Takeshi Machida Department of Immunology, Fukushima Medical University, Fukushima, Japan<strong>Significant role for splenic marginal zone B cells in anti-dsDNA autoantibody production in

lupus-prone mice with an MRL background</strong>

100191 2-B-W20-3-P Atsushi Nomura Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan Comparative analysis of neuroinflammation in Lupus-prone mice

100131 2-B-W20-4-O/P Takamasa Cho Division of Clinical Nephrology and Rheumatology,Niigata University, Niigata,Japan Anti-ribosomal-P antibody induces psychosis and hepatitis

100407 2-B-W20-5-P Hiroyuki NishimuraToin Human Science and Technology Center, Toin University of Yokohama, Yokohama

Japan

Epistatic interaction between <em>fcgr2b</em> and <em>Slam</em> family genes in susceptibility to

defective foreign protein-induced tolerance

100096 2-B-W20-6-O/P Sonia ZeggarDepartment of Nephrology,Rheumatology,Endocrinology and Metabolism,Okayama

University graduate school of medecine,Okayama,JapanLgals9 deficiency attenuates nephritis and arthritis in pristane induced mice model of SLE

100196 2-B-W20-7-O/P Shin-Ichiroh Saitoh The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ADP-libosylation factor-like 8b is required for pathogenesis of mouse models of Systemic Lupus

Erythematosus

100430 2-B-W20-8-P Akira IizukaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki,

JapanThe regulatory role of Allergin-1 in autoantibody production

100119 2-B-W20-9-O/P Norio HanataDepartment of Allergy and Rheumatology, Graduate School of Medicine, The

University of Tokyo, Tokyo, JapanThe effects of <em>peptidylarginine deiminase 4</em> in imiquimod-induced lupus model mice.

100348 2-B-W20-10-O/P Masahiro Nakashima Immunology and Microbiology, National Defense Medical College, Tokorozawa, JapanRepeated administrations of &alpha;-galactosylceramide slow the progression of lupus nephritis in

BWF1 mice

100068 2-B-W20-11-P Chi LiuDivision of Transplantation Immunology, National Center for Child Health and

Development, Tokyo, Japan

<strong>Combination of 5-aminolevulinic acid and iron prevents skin fibrosis in murine

sclerodermatous grafts-versus-host disease</strong>

100544 2-B-W20-12-O/P Takuto OhkiDivision of Psychoimmunology, Institute for Genetic Medicine, Graduate School of

Medicine, Hokkaido University

<strong>Symmetric-Gateway Reflex, which develops </strong><strong>symmetrical inflammation

between joints is induced by the specific sensory pathway in a rheumatoid arthritis model</strong>

100644 2-B-W20-13-P MUNENAGA SHUICHIDepartment of Periodontal Medicine, Division of Applied Life Science, Institute of

Biomedical &amp; Health Sciences, Hiroshima University, Hiroshima, Japan

Involvement of C5a in the progression of experimental arthritis in SKG mice induced by

<em>Porphyromonas gingivalis </em>infection

100072 2-B-W20-14-P Mareki OhtsujiToin Human Science and Technology Center, Department of Biomedical Engineering,

Toin University of Yokohama,Kanagawa,Japan

<strong>Inhibitory effect of the blocking of monocyte recruitment from the blood on spontaneously

occurring arthritis </strong><strong>in arthritis-prone Fc&gamma;RIIB-deficient mice</strong>

100092 2-B-W20-15-P Nobuhito NEMOTO Department of immunology, Yamagata University, Yamagata, Japan Integrated analysis of intestinal immunity at initial onset and relapse stages in arthritis mouse model

100593 2-B-W20-16-P Chiharu TomiDepartment Immunology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo,

JapanRoles of NR4A2 for pathogenic properties of autoreactive T helper cells in lupus-prone mice.

100640 2-B-W20-17-P Ryota SakaiDepartment of Microbiology and Immunology, School of Medicine, Keio University,

Tokyo, JapanMigration Th17 and CCL22/17-CCR4 axis are crucial in the crescentic glomerulonephritis model

100143 2-B-W20-18-P Yuki TanakaPsychoimmunology, Institute for Genetic Medicine, Hokkaido University, Sapporo,

Japan

<strong>Enriched environment, which might suppresses the Gateway Reflex attenuated the

development of EAE via inhibiting immune cell accumulation in the L5 spinal cord.</strong>

100661 2-B-W20-19-P Mari KamiyaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo

Medical and Dental University (TMDU), Tokyo, Japan

Study of <em>in vitro</em> T cell/myotube interaction disclosed invasive and cytotoxic nature of

CD8<sup>+</sup> cells enclosed in the muscle cells.

100443 2-C-W21-1-O/P Kiyomi SHITAOKADepartment of Innovative Cancer Immunotherapy, Graduate School of Medicine and

Pharmaceutical Sciences, University of Toyama, Toyama City, Japan

Majority of tumor infiltrating lymphocytes in B16F10 melanoma recognized tumor-associated antigens,

but not melanoma-associated antigens or neoantigens.

100142 2-C-W21-2-P Hiroshi HamanaDepartment of Innovative Cancer Immunotherapy, Graduate School of Medicine and

Pharmaceutical Sciences, University of Toyama, Japan

T cell receptor (TCR) gene cloning from tumor infiltrating lymphocytes of breast cancer patients toward

TCR gene therapy

100209 2-C-W21-3-P Yusuke TakahashiDepartment of Immunology, Graduate School of Medicine and Pharmaceutical

Science, University of Toyama, Japan

<strong>T cell receptor repertoire of PD-1<sup>+</sup>CD137<sup>+</sup> and PD-

1</strong><strong><sup>&minus;</sup></strong><strong>CD137</strong><strong><sup>&minus;</s

up></strong><strong> tumor infiltrating lymphocytes in various cancers</strong>

100467 2-C-W21-4-P Eiji Kobayashi Department of Immunology, University of Toyama, Toyama, JapanTCR repertoire analysis of antigen-specific T cells using immunospot array assay on a chip (T-ISAAC)

technology

100123 2-C-W21-5-P Shuhei YonamineDepartment of Dermatology, Graduate School of Medicine, University of the Ryukyus,

Nishihara, Okinawa, Japan.

Rapid isolation of tumor antigen specific antibodies from semi-synthetic alpaca VHH phage display

library for cancer immunotherapy.

100328 2-C-W21-6-O/P Satomi OkadaDepartment of Oncology, Nagasaki University Graduate School of Biomedical

Sciences, Nagasaki, Japan

Development of TCR gene therapy with allogeneic &ldquo;Stealth T cells&rdquo; deficient in

endogenous TCR and HLA class I molecules

100327 2-C-W21-7-O/P Ngoc M Pham Department of Surgery, Shiga University of Medical Science, Otsu, JapanCo-stimulation via OX40 signal <em>in vitro</em> to generate tumor antigen-specific CTLs for

adoptive cell transfer therapy

100571 2-C-W21-8-O/P Raul VizcardoSurgery Branch, National Cancer Institute, National Institutes of Health, Bethesda MD,

USADeveloping the next generation of iPSC cell-based immunotherapies

100503 2-C-W21-9-O/P Seiji Nagano Institute for Frontier Life and Medical Sciences, Kyoto University<strong>iPSCs transduced with TCR gene give rise to potent CTLs with antigen specific cytotoxic

activity comparable to those from T-iPSCs </strong>

100029 2-C-W21-10-P Soki KashimaDepartment of immunology, Institute for Frontier Life and Medical Sciences, Kyoto

University, Kyoto, Japan

WT1-specific CTLs regenerated from T cell derived iPS cells exert therapeutic effect in xenograft

model of renal cell carcinoma

100039 2-C-W21-11-P Rong ZhangDivision of Cancer Immunotherapy, Exploratory Oncology Research &amp; Clinical

Trial Center, National Cancer Center, Kashiwa, JapanType 1 IFN-producing myeloid cells influence on host immune system to inhibit tumor growth

100646 2-C-W21-12-O/P Yoshihiro MiyaharaDepartment of Immuno-Gene Therapy, Mie University Graduate School of Medicine,

Mie, Japan

A novel CAR-T therapy targeting MAGE-A4<sub>p230-239</sub>/HLA-A*02:01 complex for solid

tumors

100351 2-C-W21-13-P Kento FujiwaraProject for Vaccine and Immune Regulation, Graduate School of Pharmaceutical

Sciences, Osaka University

Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP

for clinical research

16:00-17:00

16:00-17:00

16:00-17:00

W20Systemic autoimmune

disease (1)

Dec. 13

(Wed.), 2017

W21 Cancer Cell TherapyDec. 13

(Wed.), 2017

W19 Mucosal-Skin Immunity-1Dec. 13

(Wed.), 2017

6 / 13

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The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100062 2-F-W22-1-O/P Yoichi SutohIwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba,

Japan

<strong>Origin of thymic selection inferred from the deviated antigen receptor usage in

lamprey</strong>

100184 2-F-W22-2-O/P Katsuto Hozumi Tokai University School of Medicine, Isehara, JapanMolecular machinery for the maintenance of differentiation potential toward T/B cell lineages in

hematopoietic stem/progenitor cells by Lmo2

100271 2-F-W22-3-P Shinji Fujimoto Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan D1V14(inverted), an oddly rearranged <em>Tcrb</em> in normal thymus

100592 2-F-W22-4-P Honomi SaitoDepartment of Molecular and Cellular Immunology, Shinshu University School of

Medicine, Matsumoto, JapanForced over-expression of T-bet transcription factor in thymocytes inhibits DN to DP transition

100101 2-F-W22-5-O/P Satoshi Kojo Lab. for Transcriptional Regulation, RIKEN IMS, Yokohama, JapanRegulation of Runx3 activity in immune system development by the C-terminal end amino acid

sequence

100377 2-F-W22-6-P Haruki Katsumata Dept of Urology, Tokyo Women’s Medical Univ, Tokyo, Japan.

In Vitro Stimulation with &alpha;-galactosylceramide Expands

CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>&minus;</sup> Regulatory T Cell Precursors in

Murine Thymocytes

100091 2-F-W22-7-O/P Kenta Kondo Institute of Advanced Medical Sciences, University of Tokushima, Tokushima, Japan.Thymoproteasome-dependent positive selection conditions <em>in vivo</em> immune responses in

CD8<sup>+</sup> T cells

100538 2-F-W22-8-O/P Takeshi Nitta Department of Immunology, The University of Tokyo, Tokyo, Japan <strong>Human thymoproteasome variations influence CD8 T cell repertoire</strong>

100423 2-F-W22-9-P Kana Misawa Kitasato University School of Medicine, Sagamihara, JapanAnalyses of genes expressed in the cortical thymic epithelial cells in immuno-compromised,

<em>alymphoplasia</em> mice

100134 2-F-W22-10-O/P Kazumasa Kaneko Graduate School of Engineering, The University of Tokyo, Tokyo, Japan Mathematical modeling of thymic T cell development via interaction with thymic epithelial cells

100542 2-F-W22-11-P Masashi Kajita Institute of Industrial Science, The University of Tokyo, Japan Affinity amplification for selective T cell response to specific ligands

100133 2-F-W22-12-P Ryo Yokota Institute of Industrial Science, the University of Tokyo, Tokyo, Japan Quantification of inter-sample differences in repertoire of T cell receptors

100183 2-F-W22-13-P Hiromichi Tsurui Department of Pathology, Juntendo University School of MedicinePrecise estimation of residue-residue interaction in TCR-pMHC complex by Fragment Molecular

Orbitan (FMO) calculation

100019 2-F-W22-14-O/P Osamu Kaminuma Center for Life Science Research, University of Yamanashi Establishment of non-transgenic monoclonal T cell receptor-expressing mice

100447 2-F-W22-15-P Fu Lian LYUDepartment of Immunology, Graduate School of Medicine and Pharmaceutical

Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

A novel method to produce high amounts of recombinant MHC/peptide complexes for isolation of

antigen-specific human TCRs

100596 2-F-W22-16-P Takeyuki Shimizu Department of Immunology, School of Medicine, Kochi University, Kochi, Japan Construction of a TAP deficient HLA class I-binding assay system with the use of CRISPR/Cas9 system

100658 2-F-W22-17-P Yasuo OuchiDepartment of Mucosal Immunology, School of Medicine, Chiba University, Chiba,

Japan

<strong>Generation of tumor antigen-specific CD8<sup>+</sup> T-cells with enhanced anti-tumor

activity via highly efficient CRISPR/Cas9 genome editing</strong>

100050 2-G-W23-1-O/P Kazuhiko YamamuraDepartment of Dermatology, Graduate School of Medical Sciences, Kyushu University,

Fukuoka, JapanThe transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

100058 2-G-W23-2-O/P Akihiko MurataDivision of Immunology, Department of Molecular and Cellular Biology, School of Life

Science, Faculty of Medicine, Tottori University, JapanLocal skin memory response in contact dermatitis involves tissue resident memory T cells

100164 2-G-W23-3-O/P Seiji KamijoAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine,

Tokyo, Japan

Protease allergen-induced local IL-17A production in skin tissue and accumulation of IL-

17A<sup>+</sup> &gamma;&delta; T cells in skin draining lymph nodes; possible contribution to

enhancement of skin eosinophilia and serum IgE response

100201 2-G-W23-4-P Worawalun HIRUNWIDCHAYARATDepartment of Molecular Immunology, Graduate School, Tokyo Medical and Dental

University.

Site-specific regulation of oral mucosa-recruiting CD8<sup>+</sup> T cells -Comparison of contact

allergy between skin and oral mucosa-

100400 2-G-W23-5-O/P Kazumasa Kanemaru Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan <strong>Clec10a suppresses house dust mite-induced dermatitis</strong>

100451 2-G-W23-6-P Ken Igawa Department of Dermatology, Dokkyo Medical University, Mibu, JapanTherapeutic effect of the improved version Stat6 decoy ODN containing ointment utilizing new

technology ILTS&reg; on murine skin inflammatory responses.

100455 2-G-W23-7-P Sekiguchi KotaLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences,

University of Shizuoka, Shizuoka, JapanA triacylglycerol, tributyrin, has an adjuvant effect in a mouse contact hypersensitivity model

100501 2-G-W23-8-P Takeshi WadaDivision of Molecular Medicine, Institute for Genome Research, Tokushima University,

Tokushima, JapanExacerbation of oxazolone-induced atopic dermatitis in a mouse model of hyper-IgE syndrome

100554 2-G-W23-9-P Tsukasa Ugajin Tokyo Medical and Dental University, Tokyo, Japan<strong>Bilirubin oxidation derived from oxidative stress is associated with disease severity of atopic

dermatitis</strong>

100583 2-G-W23-10-P Masayuki KitajimaDepertment of Immunology and Pathology, Research Institute National Center for

Global Health and MedicineRole of TSLPR on CD4 T cells in exacerbation of skin inflammation.

100605 2-G-W23-11-P Michiyuki Kasai Department of Immunology, School of Medicine, Kochi University,Application with nano-sized cyanoacryl particles ameliorates experimental dermatitis through the

bacteriocidal activity

100650 2-G-W23-12-P Eri SHIMURA Juntendo University, School of Medicine Influence of IL-21 signaling on skin dendritic cells

100664 2-G-W23-13-O/P Yoshinori YamanishiDepartment of Immune Regulation, Graduate School of Medical and Dental Sciences,

Tokyo Medical and Dental University (TMDU), Tokyo, JapanBasophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation

100213 2-G-W23-14-P Chang-Hyun Kim College of Medicine, Dongguk University, Gyeonggi-do, South KoreaProtective effects of agonistic anti-4-1BB antibody on the development of imiquimod-induced psoriasis-

like dermatitis in mice

100081 2-G-W23-15-O/P MAYUMI UETADepartments of Frontier Medical Science and Technology for Ophthalmology, Kyoto

Prefectural University of Medicine, Kyoto, Japan

Difference in the tear cytokines between chronic Stevens-Johnson syndrome patients and Atopic

keratoconjunctivitis

100073 2-G-W23-16-P Kazunobu OKONDepartment of Applied Biological Chemistry, Tokyo University of Agriculture and

TechnologyStudies of the anti-allergic activity of honeybush

100394 2-G-W23-17-P Hee Soon Shin Korea Food Research Institute, Sungnam-si, KoreaBaicalein induces CD4+Foxp3+ T cells and enhances intestinal barrier function in a mouse model of

food allergy

100645 2-G-W23-18-P Noufa Alonazi Prince Sultan Military Medical City, Riyadh, Saudi ArabiaThe Relationship Between Vitamin D deficiency and the severity of symptoms of Food Allergy in

Children

100481 2-H-W24-1-O/P Miwa SasaiDepartment of Immunoparasitology, Research Institute for Microbial Diseases, Osaka

University, Osaka, Japan

<strong>Critical roles of GABARAPs on interferon-mediated cell-autonomous immune responses

against <em>T. gondii</em> infection</strong>

100168 2-H-W24-2-O/P Mana MiyakodaDivision of Immunology, Department of Molecular Microbiology and Immunology,

Graduate School of Biomedical Sciences, Nagasaki University

Mechanisms underlying metformin-mediated enhancement of the protective immune responses against

malaria infection.

100361 2-H-W24-3-P Takeshi OnoDepartment of Global Infectious Diseases and Tropical Medicine, National Defense

Medical College

CD8<sup>+</sup> T cell immune responses during the <em>Plasmodium berghei</em> ANKA blood

stage infection

100238 2-H-W24-4-O/P Sayuri NakamaeDivision of Immunology, Department of Molecular Microbiology and Immunology,

Nakgasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Modulation of T-cell immune responses to pathogenic malaria parasites by prior infection with different

species of malaria parasites

100343 2-H-W24-5-P Kenji IshiwataDepartment of Tropical Medicine, The Jikei University School of Medicine, Tokyo,

Japan

T cell-dependent long-lasting blockade of mucosal penetration by infective larvae of a murine

gastrointestinal nematode

100425 2-H-W24-6-P Koubun Yasuda Department of Immunology, Hyogo College of MedicineIL-33-dependent resistance of <em>Strongyloides venezuelensis</em>-experienced mice against

<em>Nippostrongylus brasiliensis</em> infection

100549 2-H-W24-7-O/P Fumiji Saito Research Institute for Microbial Diseases, Osaka University, Osaka, Japan<strong>Immune evasion of <em>Plasmodium falciparum</em> by RIFIN </strong><strong>via

inhibitory receptor</strong>

100017 2-H-W24-8-P Risa Nakamura Department of Parasitology, NEKKEN, Nagasaki University, Nagasaki, Japan Type 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice

100623 2-H-W24-9-P Mizuho TabataDepartment of Parasitology and Infectious Diseases, Gifu University Graduate School

of Medicine, Gifu, JapanInfection of parasitic nematode ameliorates imiquimod (IMQ)-induced psoriasis

100206 2-H-W24-10-O/P Odsuren SukhbaatarDepartment of Molecular Microbiology and Immunology, Nagasaki University Graduate

School of Biomedical Science, Nagasaki, JapanRole of Interleukin-27 in the regulation of immune responses against chronic malaria infection

100580 2-H-W24-11-O/P Piyarat SrinontongDepartment of Parasitology and Infectious Diseases, Gifu University Graduate School

of Medicine, Gifu, JapanRegulation of Visceral Leishmaniasis by Secreted Immunoglobulin Deficiency

100219 2-H-W24-12-O/P Shin-Ichi Inoue Department of Infectious Diseases, Kyorin University School of Medicine, Tokyo, Japan<strong>Maintenance of immunological memory to malaria is impaired by <em>Salmonella</em>

infection</strong>

100020 2-H-W24-13-P Motoko MorimotoSchool of Food, Agricultural, and Environmental Sciences, Miyagi University, Sendai

City, Miyagi, Japan

Antibiotic-induced changes in the intestinal microbiota affect the host resistance against helminths in

murine small intestine

100145 2-H-W24-14-P Caroline M. KijogiDivision of Immunology, Department of Molecular Microbiology and Immunology,

Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

<strong>T-cell responses to <em>Plasmodium falciparum </em>and <em>Schistosoma mansoni

</em>infections in asymptomatic children living in the endemic region of Mbita, western

Kenya.</strong>

16:00-17:00

16:00-17:00

16:00-17:00W24Immune response to

parasite infections

Dec. 13

(Wed.), 2017

W22

T cell-1: T cell

development and

repertoire selection

Dec. 13

(Wed.), 2017

W23

Allergy-3 : Allergic

dermatitis, food allergy

and allergic conjunctivitis

Dec. 13

(Wed.), 2017

7 / 13

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The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100018 2-I-W25-1-O/P Tomofumi UtoDivision of Immunology, Department of Infectious Diseases, Faculty of Medicine,

University of Miyazaki, Miyazaki, Japan

Critical role of plasmacytoid dendritic cells in the induction of oral tolerance for the control of allergic

sensitization

100368 2-I-W25-2-O/P Alessandro Nasti System Biology, Kanazawa University, Kanazawa, Japan

<strong>The CD45<sup>+</sup> subset in murine uncultured adipose tissue-derived stromal cells

features immune-inhibitory M2 macrophage-like cells</strong><strong> contributable for

</strong><strong>therapeutics </strong><strong>of </strong><strong>acute h

100094 2-I-W25-3-O/P Hisako Kayama Graduate School of Medicine, Osaka University, Suita, JapanSpi-C inhibits expression of a subset of Toll-like receptor 4-inducible genes in intestinal

CX<sub>3</sub>CR1<sup>high</sup> macrophages and prevents colonic inflammation

100607 2-I-W25-4-O/P Keita AoiDepartment of Immunology and Cell Biology, Graduate School of Medicine / Frontier

Biosciences, Osaka University, Osaka, Japan

Oral mucosa-specific macrophage subsets contribute to tolerance induction in sublingual

immunotherapy

100065 2-I-W25-5-O/P Sho SendoDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate

School of Medicine, Kobe, Japan.

<strong>CD11b<sup>+</sup>Gr1<sup>dim</sup> Tolerogenic Dendritic Cell-like Cells Differentiated

from Monocytic-MDSCs Suppress the Progression of Interstitial Lung Disease in SKG Mice</strong>

100459 2-I-W25-6-O/P Yoshimitsu NakanishiDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of

medicine, Osaka University, Osaka, JapanSema6D prevents excess inflammation during high-fat feeding by controlling mitochondrial metabolism.

100035 2-I-W25-7-P Yo UedaDepartment of Rheumatology and Clinical immunology, Kobe University Graduate

School of Medicine, Kobe, Japan

<strong>Inhibition of the mTOR Pathway and Glutaminolysis Facilitates the Expansion of Myeloid-

Derived Suppressor Cells and Synergistically Ameliorates Arthritis in SKG Mice</strong>

100025 2-I-W25-8-P Yasuyuki Negishi Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan Adoptive transfer of innate immune cells induce murine fetal loss

100171 2-I-W25-9-P Hideki Minematsu Katayama Chemical Industries Co.,Ltd, Osaka, Japan Effects of liposome-encapsulated clodronate which can deplete macrophages <em>in vivo</em>.

100220 2-I-W25-10-P Hiroki HIRAMALaboratory of Immunology, Graduate School of Health Sciences, Niigata University,

Niigata, JapanThe effects of ovariectomy on autoimmune hepatitis and hepatic dendritic cells.

100256 2-I-W25-11-P Seiki ShiraiLaboratory of Nano-design for Innovative Drug Development, Graduate School of

Pharmaceutical Sciences, Osaka UniversityDevelopment of dendritic cell-targeting peptides that induce antigen-specific immune tolerance

100555 2-I-W25-12-O/P Matsumoto MinoruDivision of Molecular Immunology, Institute for Enzyme Research, Tokushima

University, Tokushima, Japan

Transgenic human AIRE expression in NOD acquired resistance to the diabetes due to the impaired

presentation of self-antigens in the pancreas

100550 2-I-W25-13-O/P Yuta ShimizuDepartment of Immunochemistry, Research Institute for Microbial Disease, Osaka

University, Laboratory of ImmunochemistryChemical compounds that specifically inhibit aberrant MHC class II expression

100287 2-I-W25-14-P Miya YoshinoDivision of Immunology, Department of Molecular and Cellular Biology, School of Life

Science, Faculty of Medicine, Tottori University, Yonago , JapanMeasurement of the transport of skin self-antigens under inflammatory conditions

100606 2-I-W25-15-P Kouta FujikuraChiba Institute of Technology, Graduate School of Engineering, Department of Life and

Environmental Sciences, Narashino,JapanBioimaging Analysis for Endocytosis of macrophage in inframmation regulated by v-ATPase

100233 3-A-W26-1-O/P Takumi MaruhashiDivision of Immune Regulation, Institute for Genome Research, Tokushima University,

Tokushima, Japan

Immuno-inhibitory co-receptor LAG-3 regulates immunodominance and autoimmunity by virtue of its

conformation-dependent recognition of MHCII

100251 3-A-W26-2-O/P Hikari Okamura Division of Immune Regulation, Institute for Genome Research, Tokushima University Single-cell analysis of autoreactive T cells under the control of PD-1

100595 3-A-W26-3-P Ami TakahashiLaboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido

University, Hokkaido, JapanHLA-G2 gives immunosuppressive effects to human monocytes and dendritic cells

100166 3-A-W26-4-O/P Daisuke KimuraDivision of Immunology, Department of Molecular Microbiology and Immunology,

Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanInterleukin-27-dependent loss of CD4<sup>+</sup> T cell-memory during malaria infection

100130 3-A-W26-5-O/P Shigenori NagaiDepartment of Molecular Immunology, Tokyo Medical and Dental University, Tokyo,

JapanPI3K-Akt pathway enhances type 1 regulatory T cell differentiation induced by IL-27

100354 3-A-W26-6-P Hirotaka Kuwata School of dentistry, Showa University, Tokyo, JapanMicroarray and gene co-expression analysis reveals that melatonin attenuates immune responses and

modulates actin rearrangement in macrophages.

100408 3-A-W26-7-P Yuya YoshidaDepartment of Pathological Biochemistry, Faculty of Pharmaceutical Sciences,

Setsunan University, Osaka, Japan

Induction of immune tolerance by combination treatment with fingolimod (FTY720) plus pathogenic

antigen in a glucose-6-phosphate isomerase peptide-induced arthritis mouse model: the fourth report

100494 3-A-W26-8-P Yuka TanakaDepartment of Gastroenterological and Transplant Surgery, Hiroshima University,

Hiroshima, Japan

Human endothelial-like cells transdifferentiated from peripheral CD14<sup>+</sup>monocytes inhibit T

cells in response to allo-stimulation

100536 3-A-W26-9-O/P Xiaotong CuiLaboratory of Infection and Prevention, Department of Virus Research, Institute for

Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan<strong>Interactions between Regnase-1 and Roquin Regulate Helper T Cell Polarization</strong>

100562 3-A-W26-10-O/P Kazuki KishidaDepartment of Immunochemistry, Research Institute for Microbial Diseases, Osaka

University<strong>Antigen-specific immune regulation mediated by TCR-like antibodies</strong>

100076 3-A-W26-11-P Cuiying HeDepartment of Immunology and Parasitology, University of Occupational and

Environmental Health, Kitakyushu, Japan.

<strong>Urban particulate matter 2.5 induced immunosuppression in splenocytes is related with

lipopolysaccharide level on particulate matter 2.5</strong>

100239 3-A-W26-12-P Manabu KinoshitaDepartment of Immunology and Microbiology, National Defense medical College,

Saitama, Japan

<strong>LPS tolerance recruits CD11b<sup>+</sup> macrophages to the liver with enhanced

bactericidal activity and low TNF-releasing capability, resulting in drastic resistance to lethal

septicemia</strong>

100516 3-A-W27-1-O/P Ryoji Kawakami Immunology Frontier Research Center, Osaka university, Osaka, Japan Epigenomic signatures of extrathymic-derived regulatory T-cells

100267 3-A-W27-2-P Akane Hara Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan Theoretical study of relationship between allergy and intestinal microbiome.

100418 3-A-W27-3-P Yuji KashiwakuraDepartment of Immunology, Dokkyo Medical University School of Medicine, Mibu,

Tochigi, JapanHeparin induces regulatory T cells by IL-2 production in mice

100589 3-A-W27-4-O/P Yumi Yamashita-KanemaruDepartment of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba,

Ibaraki, JapanDNAM-1 limits Treg cell function via TIGIT-dependent manner

100424 3-A-W27-5-P Hidefumi KojimaDepartment of Immunology, Dokkyo Medical University School of Medicine, Tochigi,

JapanFatty acids affect regulatory T cell metabolism and function during immune responses.

100442 3-A-W27-6-P Chihiro Ohashi Kitasato University School of Medicine, Sagamihara JapanSpontaneous accumulation of myeloid-derived suppressor cell (MDSC)-like CD11b<sup>+</sup>/Gr-

1<sup>+</sup> cells in the periphery of NF-&kappa;B-inducing kinase (NIK) mutant mice.

100389 3-A-W27-7-O/P Yoshiaki Yasumizu Faculty of Medicine, Osaka University, Osaka, Japan Significance of the regulatory T cell-specific epigenetics in autoimmune disease susceptibility

100460 3-A-W27-8-P Sayuri FukushimaGraduate School of Food, Agricultural and Environmental Sciences, Miyagi University,

Miyagi, Japan

Specific expression of C3 components, C3b, iC3b with increase of IL-10 and TGF-&beta; in

uterus&rsquo;s endometrium of mouse for the latter pregnant period

100470 3-A-W27-9-P Naoko NegishiAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine,

Tokyo, Japan

CD155-mediated signaling through TIGIT is involved in serial transfer of tolerant state into na&iuml;ve T

cells

100578 3-A-W27-10-O/P Chikako Shimokawa Department of Parasitology, Graduate School of Medicine, Gunma University, Gunma Suppression of type 1 diabetes in mice infected with an intestinal nematode

100510 3-A-W27-11-P Tomoyuki Yamaguchi Research Institute Nozaki Tokushukai, Osaka, Japan<strong>A simulation model of immune response predicts essential functions of Treg to maintain

immune tolerance</strong>

100570 3-A-W27-12-P YUN GUODepartment of Immunology, Graduate School of Biomedical &amp; Health Sciences,

Hiroshima University, Hiroshima, JapanUbiquitin-modifying enzyme A20 plays a role in regulatory T cells

100633 3-A-W27-13-P Yoshihiro OyaDepartment of Rheumatology, Allergy &amp; Clinical Immunology National Hospital

Organization Chiba-East National Hospital , Chiba, Japan

Allo-specific Foxp3<sup>+</sup>CD4<sup>+ </sup>induced Tregs (allo-iTreg) suppress specific-

alloantigen, but not irrelevant alloantigen in vivo

100030 3-A-W27-14-O/P Hiroki SatookaDepartment of Fundamental Biosciences, Shiga University of Medical Science, Shiga,

JapanThe ERM protein moesin regulates CD8<sup>+</sup> regulatory T cell homeostasis and self-torelance

100564 3-A-W27-15-O/P Reiko Takahashi Research Institute Nozaki Tokushukai, Daitou, JapanInhibition of melanoma proliferation by immunologic mechanism including the plasticity of SOCS1

deficient regulatory T cells

100334 3-B-W28-1-O/P Shinya HatanoDivision of Host Defense, Medical Institute of Bioregulation, Kyushu University,

Fukuoka, Japan.Development of new monoclonal antibody specific for murine V&gamma;6 chain

100075 3-B-W28-2-O/P Tsukasa NabekuraLife Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba,

Ibaraki, Japan

Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus

infection

100597 3-B-W28-3-P Maia InoueDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The

University of Tokyo, Tokyo, JapanA critical epigenetic regulator of early iNKT cell development

100395 3-B-W28-4-O/P Eri IshikawaDepartment of Molecular Immunology, Research Institute for Microbial Diseases,

Osaka University, Osaka, JapanA critical role of protein kinase D in NKT cell development

100286 3-B-W28-5-O/P Hiroshi Watarai Division of Stem Cell Cellomics, Institute of Medical Science, University of Tokyo<strong>A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Technology

Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease</strong>

100653 3-B-W28-6-P Kato Taiki Kitasato University School of Medicine,Sagamihara,JapanTetramer-based analyses of antigen-specific T cells in relapse model of experimental autoimmune

uveoretinitis in mice

100487 3-B-W28-7-P Masashi SATOHDepartment of Immunology, Kitasato University, School of Medicine, Sagamihara,

JapanGeneration of CD1d-negative NKT-cell hybridomas

100495 3-B-W28-8-P Shusaku KobayashiDepartment of Immunology, Kitasato University Graduate School of Medical Sciences,

Sagamihara, JapanCardiac CD1d+ cells that present &alpha;-GalCer and activate NKT cells

100511 3-B-W28-9-P Iwayama Toshitsugu Kitasato University School of Medicine, Sagamihara, JapanDevelopment of experimental autoimmune myocarditis model and experimental therapeutics with NKT

cell ligands

100057 3-B-W28-10-P Masato Kamei Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan MAIT cells exacerbate the disease course of oxazolone colitis.

100060 3-B-W28-11-O/P Goh Murayama Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan Role of mucosal-associated invariant T cells in lupus pathogenesis

100392 3-B-W28-12-O/P Asako Chiba Department of Immunology, Juntendo University, Tokyo, Japan MAIT cells exacerbate the disease course of oxazolone colitis.

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17:00-18:00

16:00-17:00

W28Innate Lymphocyte-1

(NKT, MAIT, gdT, NK)

Dec. 14

(Thu.), 2017

W26Tolerance and immune

suppression -1

Dec. 14

(Thu.), 2017

W27Tolerance and immune

suppression -2

Dec. 14

(Thu.), 2017

W25

Dendritic cells and

Macrophages-1: Organ-

specific Immune

Tolerance

Dec. 13

(Wed.), 2017

8 / 13

Page 9: Session Title Date Time Submission ID Program No. 1st ... · The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster Session Title Date Time Submission ID

The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100566 3-B-W29-1-O/P Takashi EbiharaLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical

SciencesRunx proteins suppress constitutive activity of ILC2 and prevent ILC2 exhaustion after activation

100448 3-B-W29-2-P Koga Satoshi Laboratory for Innate Immune Systems, RIKEN IMS, Kanagawa, JapanDevelopmental trajectory of tissue-resident ILC2 from primary lymphoid organs to the peripheral

microenvironment

100465 3-B-W29-3-P Yasutaka MotomuraLaboratory for Innate Immune Systems, RIKEN Center for Integrative Medical

Sciences, Yokohama, JapanRegulation of ILC2-mediated antigen non-specific immune responses by cysteinyl leukotriene

100047 3-B-W29-4-O/P Takanori SoDepartment of Microbiology and Immunology, Tohoku University Graduate School of

Medicine, Sendai, Japan

Early activation of group 2 innate lymphoid cells in the lung is critically controlled by the TNFR

superfamily molecule GITR

100147 3-B-W29-5-O/P Natsuko Otaki Laboratory for Innate Immune Systems, RIKEN IMS The role of group 2 innate lymphoid cells in pulmonary fibrosis

100435 3-B-W29-6-P Tsutomu Yanagibashi Toyama Prefectural Institute for Pharmaceutical Research, Toyama, JapanIL-5-producing ILC2s in the large intestine contribute to T cell-independent IgA production through the

regulation of eosinophil homeostasis

100446 3-B-W29-7-O/P Naoko Satoh Laboratory for Intestinal Ecosystem, Center for Integrative Medical Science, RIKENIdentification of an ILC2 population in the stomach which responds to commensal and pathogenic

bacteria

100476 3-B-W29-8-O/P Takato Kobayashi Laboratory for Innate Immune Systems, RIKEN IMS Characterization of group 2 innate lymphoid cells in glandular tissue

100468 3-B-W29-9-O/P Mariko KamiokaDivision of Mucosal Immunology, Department of Microbiology and Immunology, The

Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Innate and adaptive immune cells regulate Paneth cell granule formation and &alpha;-defensin

secretion

100157 3-B-W29-10-P Shindo Ryodai Toho University School of Medicine, Tokyo, Japan<strong>ROR&gamma;t-positive cells mediate RIPK3- and MLKL-dependent lethal ileitis in neonatal

mice</strong>

100427 3-B-W29-11-P Daichi KOBAYASHIChiba Institute of Technology, Faculty of Engineering, Department of Life and

Environmental Sciences. Narashino, Chiba, JapanThe effect of ILC3 regulated by glial cells in gut in inflammatory condition.

100436 3-B-W29-12-P Shinichiro Sawa Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan Development of novel mouse models lacking for group 3 innate lymphoid cells.

100237 3-C-W30-1-O/P Jeong-Hwan Yoon Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Korea Repression of SMAD3 by STAT3 and c-SKI is essential for conventional dendritic cell differentiation

100240 3-C-W30-2-O/P Haruka SasakiDepartment of Immunology, Yokohama City University Graduate School of Medicine,

Yokohama, Japan

A novel distal enhancer responsible for <em>Irf8</em> expression in the mononuclear phagocyte

lineage

100622 3-C-W30-3-O/P Nobuyuki Onai Department of Immunology, Kanazawa Medical University, Ishikawa, Japan Regulation of pDC development by graded expression of E2-2

100509 3-C-W30-4-P Hideki Arimochi Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan FXR as a regulator of <em>Psmb8</em> expression is associated with macrophage differentiation

100027 3-C-W30-5-P Hirofumi Miyazaki Department of Organ Anatomy, Graduate School of Medicine, Tohoku University FABP7 is involved in the M2 polarization of macrophages via mitochondrial fatty-acid oxidation

100289 3-C-W30-6-P Hidetoshi NaraDepartment of Immunology, Yamagata University Faculty of Medicine, Yamagata,

JapanInterleukin21 arrests bone marrow derived dendritic cells PD-L1 high immunosuppressive state

100223 3-C-W30-7-P Atsuo Nakamura Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd.,Tokyo, Japan <strong>Effect of polyamines on macrophage polarization and mucosal inflammation</strong>

100530 3-C-W30-8-P Satoshi Fujiyama Department of Immunology, Faculty of Medicine, University of Tsukuba , Ibaraki, Japan Identification of marginal zone macrophages by means of flow cytometry

100290 3-C-W30-9-O/P Ryo OkadaDept. of integrated Biosciences, Grad. school of frontier Sciences, The university of

Tokyo, Tokyo, JapanDistribution of DCIR4 among various tissue-resident macrophages

100369 3-C-W30-10-O/P Naoki Matsumoto Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan Co-expression of DCIR3 and DCIR4 on monocytes

100500 3-C-W30-11-O/P Miyuki WatanabeDepartment of Molecular Immunology, Research Institute for Microbial Diseases,

Osaka University, Osaka, Japan

Early FcR&gamma;-Erk signaling determines cytokine profile of dendritic cells through C-type lectin

receptors

100402 3-C-W30-12-O/P Shojiro HajiDepartment of Molecular Immunology, Division of Host Defense, Research Institute for

Microbial Diseases, Osaka University, Osaka, Japan

Recognition of lipids from <em>Helicobacter pylori</em> by dendritic cell immunoactivating receptor

(DCAR).

100214 3-C-W30-13-O/P Masafumi Nakayama Frontier Research Institute for Interdisciplinary Sciences, Tohoku University Identification of a silica receptor associated with canonical inflammasome activation.

100260 3-C-W31-1-P Yoshiyuki Miyazaki Faculty of Agriculture, Kyushu University, Fukuoka, Japan The induction of macrophage activation by a sulfated polysaccharide fucoidan

100531 3-C-W31-2-P Tatsuo KatagiriDepartment of (Pharm)Biology Graduate School of Medicine and Pharmaceutical

Sciences, University of Toyama, Toyama, Japan

Analysis of macrophage anti-tumor activating component derived from<em> Polyporus alveolaris</em>

extract (PAE)

100275 3-C-W31-3-P Kazuko AtsumiDepartment of Pathophysiological Laboratory Sciences, Nagoya University Graduate

School of Medicine, Nagoya, Japan<strong>Analysis on signal pathway in pro-inflammatory response by diazinon</strong>

100234 3-C-W31-4-P Naho Ikari Research &amp; Development Division, Kikkoman Corporation, Chiba, JapanDouble-stranded RNA in lactic acid bacteria augments Th1 immunity via IFN-&beta; secretion by

human dendritic cells

100033 3-C-W31-5-O/P Tanapat PalagaDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok,

ThailandNotch Signaling Regulates Macrophages Activation by LPS in the Presence of Immune Complex

100148 3-C-W31-6-O/P Sayako ChibaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio

University School of Medicine, Tokyo, JapanGlycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages

100149 3-C-W31-7-O/P Akihiro KimuraDept. of Immunology and Pathology, Research Institute National Center for Global

Health and Medicine, Chiba, Japan

<strong>The novel ubiquitin ligase complex, NQO1-PDLIM2 inhibits TLR-dependent production of

selective cytokines by degrading I&kappa;B-&zeta;</strong>

100252 3-C-W31-8-O/P Rimpei MORITADepartment of Immunology, International University of Health and Welfare, School of

Medicine, Narita, JapanClathrin heavy chain is an NLRP3 partner for NLRP3 inflammasome activation

100167 3-C-W31-9-O/P Takuya YashiroDepartment of Biological Science and Technology, Faculty of lndustrial Science and

Technology, Tokyo University of Science, Tokyo, JapanDefect of NR4A3 leads to impaired ability of migration in intestinal dendritic cells

100269 3-C-W31-10-P Shiori NakanoDepartment of Biological Science and Technology, Faculty of Industrial Science and

Technology, Tokyo University of Science, Tokyo, Japan

NR4A3 is involved in function of migratory DCs and activation of T cells in FITC-induced contact

hypersensitivity

100303 3-C-W31-11-P Yuna UchidaDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo,

JapanThe role of NR4A3 in the gene expression and function of dendritic cells

100208 3-C-W31-12-O/P Takeshi NakataniDepartment of respiratory medicine and clinical immunology, Osaka Univ., Osaka,

JapanLamtor1 (p18) plays a crucial role in trafficking of dendritic cells.

100416 3-C-W31-13-P Natsuno Hama Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan Rap1 plays central role in adhesion and migration of DCs.

100163 3-C-W31-14-P Mohamad Alaa TerkawiDepartment of Orthopedic Surgery, Faculty of Medicine and Graduate School of

Medicine, Hokkaido University, Sapporo, Japan

Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene

particulate debris of orthopaedic implants uncovers a common gene expression signature of

rheumatoid arthritis

100475 3-C-W31-15-O/P Takumi Kawasaki Nara Institute of Science and Technology (NAIST), Nara, Japan <strong>Obesity regulation by PIKfyve, a lipid kinase, in macrophage</strong>

100341 3-C-W31-16-P Hiroyuki NakashimaImmunology and Microbiology, National Defense Medical College, 3-2 Namiki

Tokorozawa Saitama, Japan

Liver sinusoidal endothelial cells and resident Kupffer cells are involved in cholesterol metabolism in

mice

100028 3-C-W31-17-P Aya UshioDepartment of Oral Molecular Pathology, Graduate school of Biomedical Sciences,

Tokushima University, Tokushima, Japan

CCL22-producing resident macrophages enhances autoimmune lesions in a mouse model of

Sj&ouml;gren&rsquo;s syndrome

100572 3-C-W31-18-P Noriko MutohDepartment of Oral Interdisciplinary Medicine, Division of Pulp Biology, Kanagawa

Dental university, Yokosuka, JapanInnate immune response induce the dentin regeneration in dental pulp

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17:00-18:00

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16:00-17:00

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17:00-18:00

W30

Dendritic cells and

Macrophages-2:

Development and

Recognition

Dec. 14

(Thu.), 2017

W31

Dendritic cells and

Macrophages-3:

Inflammatory Responses

Dec. 14

(Thu.), 2017

W29Innate Lymphocyte-2

(ILC1,2,3)

Dec. 14

(Thu.), 2017

9 / 13

Page 10: Session Title Date Time Submission ID Program No. 1st ... · The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster Session Title Date Time Submission ID

The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100190 3-D-W32-1-O/P Yasuhiro KikuchiDepartment of Pathology, Sapporo Medical University School of Medicine, Sapporo,

JapanA novel HLA class I peptide encoded by a long non-coding RNA

100174 3-D-W32-2-P Ayumi Hongo Department of Pathology, Sapporo Medical University, Sapporo, JapanPresence of proline in N-terminal extensions of epitope sequences influences HLA-A24 antigen

processing and decreases CD8+ T-cell responses

100337 3-D-W32-3-P Taro Kikuchi Department of Pathology, Sapporo Medical University, Sapporo, Japan CTL responses against cancer with an MHC class I antigen-processing defect

100362 3-D-W32-4-O/P Yoh OhnukiDepartment of Immunology, Graduate School of Medicine and Pharmaceutical

Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanThe model of antigen detection system using yeast surface display library

100648 3-D-W32-5-P Kiyoshi Yoshimura National Cancer Center, Tokyo, JapanIdentification and analysis about molecules which are highly expressed in pancreatic cancer stem-like

cells

100626 3-D-W32-6-O/P Keisuke FujiiDepartment of Immuno-Gene Therapy, Mie University Graduate School of Medicine,

Mie, Japan

Phenotypic and clonality analysis of tumor-reactive CD8<sup>+</sup> T cells among TILs in human

colorectal tumor tissue

100507 3-D-W32-7-O/P Taiki MoriyaLaboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Osaka,

Japan

Tumor cell death induction enhances tumor infiltrating dendritic cell migration and increases in tumor

antigen-specific T cells.

100106 3-D-W32-8-P Shinsuke NakajimaDivision of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa

University, Ishikawa, JapanCaspase-1-induced pyroptosis potentiates anti-tumor immunity

100038 3-D-W32-9-O/P Takuto NosakaSecond Department of Internal Medicine, Faculty of Medical Sciences, Fukui

University, Eiheiji-machi, Japan

<strong>Alveolar macrophages drive hepatocellular carcinoma lung metastasis in collaboration with

interstitial macrophages</strong>

100421 3-D-W32-10-O/P Risa FujiiDepartment of Anatomy and Embryology, Faculty of medicine, University of Tsukuba,

Tsukuba, Japan

<strong>MafB inhibits tumor growth through regulating</strong> <strong>Tumor-Associated

&ndash;Macrophages in spleen</strong>

100186 3-D-W32-11-O/P Hisashi Kanemaru Research Institute for Microbial Diseases (RIMD), Osaka University, Osaka, JapanBasic leucine zipper transcription factor ATF-like 2 exhibits an anti-tumor effect through upregulation of

IL-12 p40 expression

100098 3-D-W32-12-P Hidemi Takahashi Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan

<strong>Suppression of murine tumor growth through CD8+ CTLs via activated DEC-205+ dendritic

cells by sequential administration of &alpha;-galactosylceramide in vivo: A possible mechanism for

SSM (Maruyama Vaccine)</strong>

100453 3-D-W32-13-P Yui Kuroki Reserch Institute for Biomedical Sciences,Tokyo University of Science Analysis of antigen prosenting cells that inducec CD8+ CD11c+ T cells in tumor microenviroment

100469 3-D-W32-14-O/P Hiroshi HIGUCHI School of Medicine, Tokai University, Kanagawa, JapanPhosphatidylserine-mediated incorporation of tumor-derived exosomes and phenotypic changes in

human macrophages

100599 3-D-W32-15-P Masaki TamiyaDivision of Cell signaling, Institute for Advanced Medical Research, Keio University

school of Medicine

Reversal of anti-PD-1/PD-L1 therapy resistance by modulation of tumor-associated macrophages using

CSF-1 receptor blockade

100032 3-D-W32-16-P Naosuke Morikawa Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan<strong>LY341495, an mGluR2/3 antagonist, attenuates the immunosuppressive function of myeloid-

derived suppressor cells and inhibits the melanoma tumor growth.</strong>

100432 3-D-W32-17-P Yui Ezaki Department of Immunology,Kurume University School of Medicine

<strong>Chitinase 3-like 1</strong><strong> (CHI3L1/YKL-40)</strong><strong> induces carcinogenic

changes of epithelial cells by promoting cell survival and proliferation under in vitro and in vivo

conditions</strong>

100574 3-D-W33-1-O/P Okumura Genki Department of Immunology, Faculty of medicine, University of Tsukuba The role of soluble CD155 in tumor immune response and metastasis

100299 3-D-W33-2-O/P Ibuki HaradaDepartment of Immunology, Yokohama City University Graduate School of Medicine,

Yokohama, Japan

<strong>Soluble factors produced by BCR-ABL-positive leukemic cells may compromise antitumor

immunity in chronic myeloid leukemia </strong>

100404 3-D-W33-3-O/P Hirotake TsukamotoDepartment of Immunology, Graduate School of Medical Sciences, Kumamoto

University, Kumamoto, Japan

<strong>Combined blockade of IL-6 and PD-L1 signals breaks a mutual regulation of their

immunosuppressive effects on anti-tumor immunity</strong>

100462 3-D-W33-4-O/P Haruka Wada Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University Tumor initiating cell in immunocompetent animal defined by immunological features

100055 3-D-W33-5-O/P Chie Kudo-SaitoDepartment of Immune Medicine, National Cancer Center Research Institute, Tokyo,

Japan

<strong>Targeting the pathogenic mesenchymal stromal/stem cells prevents immune

exhaustion</strong>

100634 3-D-W33-6-O/P Aya Hirata Department of Immune Medicine, National Cancer Center Research Institute Effect of Imatinib mesylate to tumor immunosuppressive microenvironment

100387 3-D-W33-7-P Mikako NishidaDepartment of Immunology, Graduate School of Medicine, Dentistry and

Pharmaceutical Sciences, Okayama University, Okayama, JapanAnti-oxidative stress response is involved in Metformin-induced anti-tumor immunity

100114 3-D-W33-8-O/P Marija MojicDivision of Pathogenic Biochemistry Institute of Natural Medicine, University of

Toyama, Toyama, Japan

<strong>Tumor-specific CTL&#39;s reduced clonality and proliferation index, not the inhibitory immune

checkpoint expression, as hallmarks of B16 melanoma immune evasion</strong>

100575 3-D-W33-9-O/P Satoshi UehaDepartment of Molecular Preventive Medicine, Graduate School of Medicine, The

University of Tokyo, Tokyo, Japan

TCR sequencing reveals the generation and expansion of tumor-specific CD8<sup>+ </sup>T cell

clones after anti-CD4 antibody treatment in tumor-bearing mice

100185 3-D-W33-10-P Wakana GotoLaboratory of Hematology and Oncology, Graduate School of Health Sciences, Niigata

University, Japan<strong>Clonal amplification of WT1 specific CTL using dendritic cell line.</strong>

100380 3-D-W33-11-P Asuka MiyamotoDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara,

Kanagawa, Japan

Production of specific IgG against HER2 peptide is decreased in NOG-IL4-Tg mice transplanted with

breast cancer patients PBMC

100514 3-D-W33-12-P Makoto TsuijiDepartment of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical

SciencesEffects of linoleic acid oxide 13-HODE and 13-HPODE on immune responses.

100612 3-D-W33-13-P Yoshinori TAKAHASHI Department of Pulmonary and Critical Care Medicine, Mie University Hospital, JapanBiomarkers including circulating PD-L1 and PD-1 in human (L858R) EGFR mutant transgenic mice

with lung cancer

100420 3-D-W33-14-P Yuetsu TanakaDepartment of Immunology, Graduate School of Medicine, University of the Ryukyus,

Okinawa, Japan

The importance of fixation/permeablization methods for flow cyotometric detection of human FoxP3

antigen as examined using human Treg and non-Treg cell lines transformed by HTLV-I

100139 3-D-W33-15-P Naoko Kumagai-Takei Department of Hygiene, Kawasaki Medical Scool, Kurashiki, JapanThe analysis for function of human CD8+T cell line with and without long-term exposure to asbestos

fibers

100332 3-D-W33-16-P Yasumitsu Nishimura Department of Hygiene, Kawasaki Medical SchoolSecretory factors produced by immune cells upon exposure to asbestos facilitate proliferation of

mesothelial cells

100103 3-E-W34-1-O/P Sachiko HiroseToin Human Science and Technology Center, Department of Biomedical Engineering,

Toin University of Yokohama, Yokohama, Japan

<strong>Independent effect of inhibitory </strong><strong>IgG Fc receptor</strong> <strong>IIB

on</strong><strong> B cells and monocytes </strong><strong>on <em>Yaa</em>-induced murine

lupus</strong>

100198 3-E-W34-2-O/P Hisashi Nomura Department of Dermatology, Keio University School of Medicine, Tokyo, JapanFc&gamma;RIIb plays an important role in maintaining clonal ignorance and prevents pemphigus

phenotype in pathogenic anti-desmoglein 3 antibody knock-in mice

100386 3-E-W34-3-O/P Hitomi Sakatani Nara Institute of Science and Technology, Nara, Japan Novel compounds that induce specifically class switching to IgA

100489 3-E-W34-4-O/P Saori Fukao Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan Regulation of IgE production by an RNA binding protein

100315 3-E-W34-5-O/P Akihiko MutoDepartment of Biochemistry, Tohoku University Graduate School of Medicine, Miyagi,

JapanSingle-cell analysis of gene regulatory network in activated B cells

100613 3-E-W34-6-O/P Adachi TakahiroDepartment of Immunology, Medical Research Institute, Tokyo Medical and Dental

University, Tokyo, Japan

Intravital imaging of Ca<sup>2+</sup> signals in lymphocytes of the Ca<sup>2+</sup> biosensor

YC3.60 transgenic mice

100089 3-E-W34-7-O/P Mineto OtaThe Department of Allergy and Rheumatology, Graduate School of Medicine, The

University of Tokyo, Tokyo, JapanAbnormal B cell receptor repertoire maturation in SLE unveiled by RNA sequencing of immune cells

100043 3-E-W34-8-O/P Tsubasa OkanoDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and

Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

Maternal B cells, engrafted in patients with X-linked severe combined immunodeficiency (X-SCID),

could undergo class switch recombination without somatic hypermutation and cause IgG1

gammopathy.

100230 3-E-W34-9-P Hanbing XueGraduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki,

Japan

Examination of &ldquo;Universal Light Chain&rdquo; models that can be paired with a wide spectrum

of immunoglobulin heavy chains maintaining their antigen-binding specificities

100159 3-E-W34-10-P Shoya YasudaDepartment of Computational Intelligence and Systems Science, Tokyo Institute of

Technology, Yokohama, JapanMathematical modeling of BAFFR-mediated B cell survival signa

100410 3-E-W34-11-P Ryouma Totera Narashino, Chiba , Japan Cultured B cells and Immune globlulin gene expression.

100429 3-E-W34-12-P Ryouma KOTERAChiba Institute of Technology, Graduate School of Engineering, Department of Life and

Environmental Sciences, Tsudanuma, Chiba ,Japan

T cell dependent and independent regulation on immune globulin gene expressions in vitro B cell

differentiation

100523 3-E-W34-13-P Nazim MedzhidovDepartment of Immunology, Medical Research Institute, Tokyo Medical and Dental

University, Tokyo, Japan<strong>Role of poor B cell receptor ubiquitination in efficient antigen presentation</strong>

100581 3-E-W34-14-P Yangyang FengDepartment of Immunology, Medical Research Institute, Tokyo Medical and Dental

University<strong>Role of NADPH oxidases in BCR ligation-induced ROS production and activation</strong>

100272 3-E-W34-15-P Miyoko MatsushimaDepartment of Pathophysiological Laboratory Sciences, Nagoya University Graduate

School of Medicine, Nagoya, Japan<strong>Deteriorated amount of IC capture without CD40 on B cells</strong>

100295 3-E-W34-16-P Haruka Saito Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan Rab13 prevents development of B cell lymphoma

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17:00-18:00

Odd Number /

16:00-17:00

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17:00-18:00

W34B cell development and

function

Dec. 14

(Thu.), 2017

W32

Tumor immunology-1

(Tumor antigens, antigen

presenting cells, anti-

tumor T cells)

Dec. 14

(Thu.), 2017

W33

Tumor immunology-2

(Immunosuppression and

modulation in tumor

immunity)

Dec. 14

(Thu.), 2017

10 / 13

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The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100426 3-E-W35-1-O/P Katsuya SatoDepartment of Molecular Pathobiochemistry, Gifu University School of Medicine, Gifu,

JapanAnalysis of cis-regulatory elements involved in the regulation of expression of <em>Aicda</em>

100126 3-E-W35-2-O/P Mayuko ShimodaLaboratory of Host Defense, Research Institute for Microbial Diseases Osaka

University, Suita, Osaka, Japan<strong>GANP maintains antibody structural integrity during somatic hypermutation</strong>

100610 3-E-W35-3-O/P Kei Haniuda Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan Germinal center B cell development by glycolysis and mitochondrial metabolism

100585 3-E-W35-4-O/P Wataru Ise Immunology Frontier Research Center, Osaka University, Osaka, Japan The heightened T-B interaction associates with plasma-prone germinal center B cells

100598 3-E-W35-5-O/P Atsuko KayabaDepartment of Experimental Immunology, Institute of Development, Aging and Cancer,

Tohoku University, Sendai, Japan

PIR-B suppresses IL-6 secretion from mesenchymal stem cells and regulates the immunoglobulin

production of plasma cells.

100527 3-E-W35-6-O/P Ari Itoh-NakadaiDepartment of Experimental Immunology, Institute of Development, Aging and Cancer,

Tohoku University, Tokyo, JapanSecretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells

100636 3-E-W35-7-O/P Koji Tokoyoda Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, Germany <em>Salmonella</em> remotely suppresses long-lasting humoral immunity

100374 3-E-W35-8-O/P Katsuki UsamiInternational Education and Research Center for Food and Agricultural Immunology,

Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan

Important role of the immunological network between large intestine and mammary gland in

breastfeeding

100406 3-E-W35-9-O/P Hirohiko OnoNational Center of Neurology and Psychiatry National Institute of Neuroscience,

Department of Immunology, Tokyo, JapanDysregulated B cells in Myalgic encephalomyelitis/Chronic Fatigue Syndrome

100245 3-E-W35-10-P Mizuki IshikawaAkita University, Graduate School of Engineering Science, Laboratory for Molecular

Cell Physiology, Akita, JapanRegulatory mechanism for intracellular sorting of Parm1 by NPxY motif.

100326 3-F-W36-1-O/P Akira NakajimaCenter for Innovation in Immunoregulative Technology and Therapeutics, Graduate

School of Medicine, Kyoto University

<strong>Mucus-associated functional factors in Bacteroidetes promotes inter-phylum</strong><strong>

symbiosis and colonic homeostasis</strong>

100338 3-F-W36-2-P Junko Nishio Institute of Industrial Science, The University of Tokyo, Tokyo, JapanSurfactant protein D directly binds to gut bacteria and regulates microbiota composition for intestinal

homeostasis

100344 3-F-W36-3-O/P Eiji Miyauchi Laboratory for Intestinal Ecosystem, IMS, RIKEN, Yokohama, JapanMimicry peptides from gut commensals stimulate myelin-specific T cells and exacerbate experimental

autoimmune encephalomyelitis

100621 3-F-W36-4-P Ichiro TakahashiDepartment of Mucosal Immunology, Dental School, Hiroshima University, Hiroshima,

Japan

Metabolic demand of colonic macrophages for symbiotic and cytosolic colonization by non-lymphoid

tissue resident commensal bacteria

100660 3-F-W36-5-O/P Takashi TanakaLaboratory for Inflammatory Regulation, REKEN Center for Integrative Medical

Sciences, Yokohama, Japan

<strong>Microbiota-dependent development of non-alcoholic steatohepatitis (NASH) in PDLIM2-

deficient mice</strong>.

100541 3-F-W36-6-P Toshiyuki KojimaDepartment of Immune Regulation, Tokyo Medical and Dental University, Tokyo,

Japan.

Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of

inhibitory receptor CD200R

100559 3-F-W36-7-P Masako KohyamaDepartment of Immunochemistry, Research Institute for Microbial Diseases, Osaka

UniversityIntestinal epithelial homeostasis regulated by CD74

100608 3-F-W36-8-P Terufumi KuboDepartment of Pathology, Sapporo Medical University School of Medicine, Sapporo,

Japan

Differential bronchial epithelial response regulated by deltaNp63: a potential mechanism explaining

chronicity of asthma

100052 3-F-W36-9-O/P Masaaki HASHIGUCHIDepartment of Immunology, Dokkyo Medical University School of Medicine, Mibu,

Tochigi, Japan

Tumor necrosis factor superfamily member (TNFSF) 13, APRIL and TNFSF13B, BAFF downregulate

homeostatic immunoglobulin production in intestines

100217 3-F-W36-10-P Katsuhiro NakanishiLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences,

University of Shizuoka, Shizuoka, JapanProduction of secretory hybrid-IgG/IgA in plant expression system

100243 3-F-W36-11-O/P Tadashi Takeuchi Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences Gut microbial metabolite acetate modulates affinity of IgA to maintain intestinal homeostasis

100457 3-F-W36-12-P Naoya TsugawaDepartment of Gastroenterology, Graduate School of Medical Science, Tokyo Medical

and Dental University, Tokyo, Japan<strong>Verification of immunoglobulin A regulation of mucosal microflora and homeostasis</strong>

100464 3-F-W36-13-P Takashi NagaishiDepartment of Gastroenteroogy, Graduate School of Medical Science, Tokyo Medical

and Dental University<strong><em>XXX</em></strong>

100293 3-F-W36-14-O/P Mayuri TanakaLaboratory of Adjuvant Innovation, Center for Vaccine and Adjuvant Research, National

Institutes of Biomedical Innovation, Health and Nutrition, Osaka, JapanEssential role of CARD14 in murine experimental psoriasis

100364 3-F-W36-15-P Noriko Sato Dept. of Plastic and Reconstructive surgery, Tohoku Univ. Effect of Mincle deficiency on the wound healing process in skin

100485 3-F-W36-16-P Takayuki MIURA Deptartment of Plastic and Reconstructive Surgery, Tohoku University, Sendai, Japan Effect of Dectin-2-mediated signaling on skin wound healing and NETosis

100601 3-F-W36-17-O/P Saeko Nakajima Department of Dermatology, Kyoto University Graduate School of Medicine<em>Candida albicans</em> skin colonization exacerbates the inflammation of murine psoriasis-like

dermatitis

100624 3-F-W36-18-O/P Gyohei EgawaDepartment of Dermatology, Kyoto University Graduate School of Medicine, Kyoto,

Japan

<strong>Revisiting the concept of CHS response; effector T cells infiltrates into the hapten-entry sites

and confer long-lasting local memory</strong>

100323 3-F-W37-1-O/P Hiroe Tetsu Laboratory for innate Immune Systems, RIKEN, IMS, Japan Role of group 2 innate lymphoid cells in the skin

100396 3-F-W37-2-P Weng Sheng KongDepartment of Immunology, Graduate School of Biomedical and Health Sciences,

Hiroshima University, japanAnalysis of gut and skin inflammation in the pathogenesis of atopic dermatitis

100504 3-F-W37-3-P Ryoki Kobayashi Nihon University, School of Dentistry at Matsudo, Chiba, JapanCharacterization of Innate lymphoid cells in inflamed gingiva of mice infected with <em>Porphyromonas

gingivalis</em>

100486 3-F-W37-4-O/P Chieko IshifuneDepartment of Immunology and Parasitology, Institute of Biomedical Sciences,

Tokushima University Graduate School, Tokushima, Japan

Notch signal controls the number of

TCR&alpha;&beta;<sup>+</sup>CD8&alpha;&alpha;<sup>+</sup> intraepithelial lymphocytes via

phospholipid asymmetry by maintaining fllipase ATP8a2

100539 3-F-W37-5-P Taku NaitoDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo,

JapanMaintenance of intestinal homeostasis by T cell-expressed Eed.

100175 3-F-W37-6-O/P Hideaki TakagiDivision of Immunology, Department of Infectious Diseases, Faculty of Medicine,

University of MiyazakiTolerogenesis of gastrointestinal plasmacytoid dendritic cells impacts the induction of oral tolerance

100253 3-F-W37-7-O/P Takashi KanayaLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences,

Yokohama, Kanagawa, Japan

IL-22 binding protein (IL-22BP) regulates the properties of follicle-associated epithelium (FAE) to

facilitate antigen uptake into Peyer&rsquo;s patches

100086 3-F-W37-8-P Tomomi Hashizume-Takizawa Nihon University School of Dentistry at Matsudo, Chiba, JapanSurface IgA<sup>+</sup> Peyer&rsquo;s patch B cells play key roles for induction of recombinant

<em>Salmonella</em>-derived antigen-specific intestinal IgA antibody responses

100584 3-F-W37-9-P Hisashi Ueta Department of Anatomy (Macro), Dokkyo Medical University, Tochigi, JapanPeyer&rsquo;s patch functions as a transition site for rapid recirculation of lymphocytes during gut

immunosurveillance: multicolor immunohistochemical study

100651 3-F-W37-10-P Lisa Fujimura Biomedical Research Center, Chiba University, Chiba, Japan Roles of enteric neurons in gut mucosal immunity.

100639 3-F-W37-11-O/P Kamachi FumitakaDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo

University of Science, Chiba, JapanEffects of gut microbial metabolites of linoleic acid on cytokine profuction by immune cells

100388 3-F-W37-12-O/P Motoyoshi Nagai Graduate School of Pharmaceutical Science, Keio University, Tokyo, JapanNutritional signals are essential for the regulation of cell dynamics and mucosal immune response in

GALT

100558 3-F-W37-13-P Sachi Tanaka Graduate School of Agriculture, Shinshu University, Nagano, Japan Caloric restriction ameliorates dextran sulfate sodium-induced colitis in mice

100155 3-F-W37-14-P Hideo Kataoka Department of Oral Microbiology, Showa University School of Dentistry, Tokyo, Japan MALDI-TOF-MS Analysis of gut microbiota in murine model of food allergy

100221 3-F-W37-15-O/P Hidehiko SuzukiLaboratory of Vaccine Materials and Laboratory of Gut Environmental System, National

Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)

Development of divalent food poisoning vaccine by augmented antigenicity of <em>Clostridium

perfringens</em> enterotoxin

100560 3-F-W37-16-P Naoki TakemuraDepartment of Mucosal Immunology, School of Medicine, Chiba University, Chiba,

Japan

Prime-boost vaccination with CpG ODN and curdlan strongly induces both systemic and mucosal

immunity

100452 3-F-W37-17-O/P Hideki Asanuma National Institute of Infectious Diseases, Tokyo, JAPAN<strong>Essential roles for protective SIgA Abs induced by nasal G9.1 combined influenza VLP

vaccine</strong>

100273 3-F-W37-18-P Yuki KanaiLaboratory of Nano-design for Innovative Drug Development, Graduate School of

Pharmaceutical Sciences, Osaka UniversityPulmonary vaccine against lung cancer developed using dendritic cell-targeting peptide

100125 3-F-W37-19-P Naoto YoshinoDivision of Infectious Diseases and Immunology, Department of Microbiology, School

of Medicine, Iwate Medical University, Iwate, JapanMucosal adjuvanticity of surfactin correlates with the surface-active property

100127 3-G-W38-1-O/P Shigeru IwataThe First Department of Internal Medicine, School of Medicine, University of

Occupational &amp; Environmental Health, Japan, Kitakyushu, Fukuoka, Japan

<strong>IFN-</strong><strong>&gamma;</strong><strong>-T-bet mediated metabolic reprograming in

T</strong> <strong>helper 1 cells</strong><strong>and </strong><strong>its relevance to

pathogenesis of SLE</strong>

100023 3-G-W38-2-O/P Maiko Okumura1st Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical

Sciences (Medicine), University of Toyama

Production of Ro52/TRIM21 autoantibodies that react to PEP08 epitope in Ro52 clinically relate to the

morbidity and severity of interstitial lung disease in connective tissue diseases.

100156 3-G-W38-3-O/P Yusuke Takeshima1Department of Allergy and Rheumatology, Graduate School of Medicine, the

University of Tokyo, Tokyo, Japan

Comprehensive analysis of genome and transcriptome analysis of immune cell subsets in peripheral

blood mononuclear cells (PBMCs) revealed mitochondria contribution in B cells to systemic lupus

erythematosus.

100331 3-G-W38-4-O/P Natsumoto BunkiDepartment of Allergy and Rheumatology, Graduate School of Medicine, The

University of Tokyo, Japan

Pathophysiological analysis of systemic lupus erythematosus (SLE) using patient-derived induced

pluripotent stem cells

100151 3-G-W38-5-P Kato YasuhiroDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of

Medicine, University of Osaka, JapanThe role of Stimulator of interferon genes (STING) in the pathogenesis of SLE

100307 3-G-W38-6-O/P Yukiko IwasakiDepartment of Allergy and Rheumatology, Graduate School of Medicine, The

University of Tokyo, Japan

Plasma metabolomic analysis combined with transcriptome data has potential for stratification of SLE

patients

100552 3-G-W38-7-O/P Yuki SasagawaLaboratory of Immunochemistry, WPI Immunology Frontier Reseach Center, Osaka

University, Osaka, Japan

Antiphospholipid antibody recognizes &beta;2GPI complexed with HLA class II molecules via its

domain V

100573 3-G-W38-8-O/P Satoko MorikamiDepartment of Obstetrics and Gynecology, Kobe University Graduate School of

Medicine, Hyogo, Japan

Prothrombin complexed with HLA class II molecules is an autoantibody target in antiphospholipid

syndrome

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W38Systemic autoimmune

disease (2)

Dec. 14

(Thu.), 2017

W36 Mucosal-Skin Immunity-2Dec. 14

(Thu.), 2017

W37 Mucosal-Skin Immunity-3Dec. 14

(Thu.), 2017

W35Germinal center reaction

and plasma cells

Dec. 14

(Thu.), 2017

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The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100083 3-G-W39-1-P Tatsuhiko OzawaDepartment of Immunology, Graduate School of Medicine and Pharmaceutical

Sciences, University of Toyama, Toyama, Japan

Evolution of anti-citrullinated peptide antibody (ACPA): analysis of autoantigen under native condition

using a human monoclonal ACPA

100071 3-G-W39-2-P Shizuyo TsujimuraThe First Department of Internal Medicine, School of Medicine University of

Occupational and Environmental Health, Kitakyushu, Japan

<strong>The Characteristic of the P glycoprotein expression on the B cell subsets in rheumatoid

arthritis</strong>

100236 3-G-W39-3-P Shinji MaedaDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City

University Graduate School of Medical Sciences

<strong>Exploratory study of T cell biomarkers predicting Abatacept treatment response in RA patients

with background adjustment by IPW method</strong>

100222 3-G-W39-4-O/P Haruka Tsuchiya Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, JapanIdentification EP300 as a Novel Therapeutic Target for Rheumatoid Arthritis by the Comprehensive

Analysis of Fibroblast-like Synoviocytes

100255 3-G-W39-5-O/P Shinsuke YasudaDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and

Graduate School of Medicine, Hokkaido University, Sapporo, Japan

<strong>RasGRP-Ras-MAPK activation in </strong><strong>fibroblast-like synoviocytes from patients

with rheumatoid arthritis and inhibition of this pathway by Ras translocation</strong>

100502 3-G-W39-6-P Hidekata YasuokaDivision of Rheumatology, Department of Internal Medicine, Keio University School of

Medicine, Tokyo, JapanPhenotype of platelet is altered in circulation of patients with rheumatoid arthritis

100036 3-G-W39-7-O/P Harumi ShiraiDepartment of Allergy and Rheumatology, Graduate School of Medicine, The

University of Tokyo, Tokyo, Japan

Investigation of pathogenesis of Adult onset Still&rsquo;s disease through lymphocyte subsets analysis

in peripheral blood followed by RNA-sequencing

100084 3-G-W39-8-O/P Noriko AraseDepartment of Immunochemistry, Research Institute for Microbial Diseases, Osaka

UniversityRecognition of SS-A/IgG/HLA-DR complex by autoantibodies in Sjogren&rsquo;s syndrome

100132 3-G-W39-9-O/P Yoshinobu KoyamaCenter for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross

Okayama Hospital,Okayama, Japan

Exercise-induced pulmonary hypertension at early stage of systemic sclerosis: changes in gene

expression of peripheral blood cells

100480 3-G-W39-10-O/P Yoshimichi OkayamaAllergy and Immunology Research Project Team, Center for Institutional Research and

Medical Education, Nihon University School of Medicine

Autoantibodies (AAbs) against the Fc&epsilon;RI &alpha;-chain and IgE in patients with chronic

spontaneous urticaria (CSU) induced statistically higher ability of Fc&epsilon;RI aggregation compared

with non-atopic control (NC) subjects

100314 3-G-W39-11-O/P Sugimori YusukeDepartment of Allergy and Rheumatology, Graduate School of Medicine, The

University of Tokyo, Tokyo, Japan

Comprehensive Flow Cytometric Analysis of Immune Cell Subsets in PBMCs from Idiopathic

Inflammatory Myopathy Patients

100635 3-G-W39-12-P Madoka Terashima Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan Establishment of a pluripotent cell model of Nakajo-Nishimura syndrome

100363 3-H-W40-1-O/P Jing Wang Institute of Enzyme Research, Tokushima University, Tokushima, Japan Tracking the fate of neutrophils in sterile injury using photoactivation and intravital imaging

100390 3-H-W40-2-P Shin MorisawaDepartment of Immunology, Kitasato University Graduate School of Medical Sciences,

Sagamihara, Japan.

Quantitative analysis of Neutrophil extracellular traps (NETs) in lupus prone mouse using novel

methods

100647 3-H-W40-3-P Matsuba ShintaroDepartment of Immunology, School of Medicine, Kanazawa Medical University,

Uchinada, JapanSLPI negatively regulates LPS-induced eosinophil activation via inhibition of Elk-1 phosphorylation

100021 3-H-W40-4-P Kensuke YanashimaAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine,

Tokyo, Japan

<strong>Synthetic host defense peptide IDR-1018 activates various functions of human mast

cells</strong>

100120 3-H-W40-5-P Kyosuke InuiDepartment of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido

University, Hokkaido, JapanSTAP-2 negatively controls Fc&epsilon;RI-mediated mast cell activation.

100122 3-H-W40-6-P Kazumi KasakuraDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo,

JapanThe effect of commensal bacteria on anaphylactic reaction

100225 3-H-W40-7-P Nobuhiro NakanoAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine,

Tokyo, JapanMast cells acquire intestinal antigen-presenting cell-like properties by Notch signaling

100247 3-H-W40-8-P Izumi FujigakiDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo,

JapanSuppression of mast cell-mediated allergic responses by valerate, butyrate, and niacin via GPR109a.

100248 3-H-W40-9-P Yuki Nakamura Department of Immunology, Faculty of Medicine, University of Yamanashi, Japan Regulation of plasma histamine levels by the mast cell clock and its modulation by stress

100276 3-H-W40-10-P Azusa KageyamaDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo,

JapanPhysiological significance of IL-10 produced by mucosal type mast cells

100281 3-H-W40-11-P Takahiro AraiDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo,

JapanTranscriptional regulation of basophil-specific proteases

100284 3-H-W40-12-P Megumi IwasakiDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo,

Japan

Generation of mutant mouse Fc&epsilon;RI&alpha;, which can be expressed as

&alpha;&gamma;<sub>2</sub> trimer and can bind to mouse IgE with high affinity

100360 3-H-W40-13-P Shotaro Nakajima Dept. Immunology, Univ. Yamanashi, Yamanashi, Japan Resveratrol inhibits IL-33-mediated mast cell activation

100370 3-H-W40-14-O/P Wakabayashi Seiichiro Dermatology, Chiba University, Chiba, JapanHomeostasis of peripheral macrophages are controlled by mast cells <em>via</em> newly identified c-

Kit<sup>+</sup>CD11b<sup>+</sup> tissue-resident macrophage progenitor cells

100434 3-H-W40-15-O/P Yuta KogureDivision of Mucosal Immunology, Department of Microbiology and Immunology, The

Institute of Medical Science, The University of Tokyo, Tokyo, JapanMesenchymal-mediated skin-specific regulatory system for the control of tissue resident mast cells

100471 3-H-W40-16-P Makiko UchidaDepartment of Biological Science and Technology, Graduate School of Industrial

Science and Technology, Tokyo University of Science, Tokyo, JapanFunctional analysis of transcription factor Ehf.

100472 3-H-W40-17-P Kazuki SaidaLaboratory of Molecular Biology and Immunology, Department of Biological Science

and Technology, Faculty of Industrial Science and Technology, Tokyo University of

Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.

Mucosal mast cell differentiation is regulated by cross-talk between Notch signaling and TGF-&beta;

signaling.

100515 3-H-W40-18-P Kumi IzawaAtopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo,

Japan

<strong>Mast cell- and IgE-dependent anaphylaxis is regulated by paired receptors LMIR3 and

LMIR7</strong>

100520 3-H-W40-19-P Shino UchidaAtopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo,

Japan<strong>A critical role of an inhibitory receptor LMIR3 in the pathogenesis of food allergy</strong>

100604 3-H-W40-20-O/P Shota ToyoshimaAllergy and Immunology Research Project Team, Center for Institutional Research and

Medical Education, Nihon University School of Medicine, Tokyo, JapanComparison of microRNA in human mast cell-derived exosomes in innate and acquired immunity

100616 3-H-W40-21-O/P Jun-ichi KashiwakuraDepartment of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido

University, Hokkaido, JapanSTAP-2 is an adopter molecule to positively regulate basophil activation

100456 3-H-W40-22-O/P Tomoyuki Bando Ono pharmaceutical co., ltd. Exploratory Research Laboratories, Osaka, JAPAN<strong>Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and

basophils</strong>

100428 3-H-W40-23-P Toshihisa NAGAOThe Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo,

Japan

Sugar modification of carrier protein confers ability on allergen to induce IgE- and basophil-mediated

allergic inflammation

100488 3-H-W40-24-O/P Takuya OHTADepartment of Immune Regulation, Tokyo Medical and Dental University Graduate

School, Tokyo, Japan

Skin-resident memory CD4<sup>+</sup> T cells play an essential role in acquired tick resistance

through IL-3-mediated basophil recruitment

100546 3-H-W40-25-P Yuya TABAKAWADepartment of Immune Regulation, Tokyo Medical and Dental University Graduate

School, Tokyo, JapanHistamine plays a critical role in acquired protective immunity against tick infestation

100637 3-H-W40-26-P Hidemitsu Tsutsui National Center for Global Health and Medicine Research Institute, Tokyo, JapanThe basophil-specific protease mMCP-8 provokes an inflammatory response in the skin with

microvascular hyperpermeability and leukocyte infiltration

100665 3-H-W40-27-O/P Kensuke MiyakeDepartment of Immune Regulation, Graduate School of Medical and Dental Sciences,

Tokyo Medical and Dental University (TMDU), Tokyo, Japan

Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II

complexes from dendritic cells (DCs)

100433 3-H-W41-1-O/P Takumi ItohDepartment of Therapy Development and Innovation for Immune disorders and

Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan

IL-26 facilitates angiogenesis and skin inflammation via inducing FGF2 production in a murine model of

imiquimod-induced psoriasis

100349 3-H-W41-2-P Zhang Baoluo Laboratory of Pharmacotherapy of Life-Style Related Diseases, Tohoku University Role of histamine in IL-17 expression in Imiquimod-induced psoriasis-like inflammation model

100399 3-H-W41-3-P Shoichiro MiyatakeDepartment of Immunology, Graduate School of Environmental Health Sciences,

Azabu University, Kanagawa, JapanDermatitis developed in GATA3 mutant mice

100482 3-H-W41-4-O/P Taro Watabe Department of gastroenterology, Tokyo Medical and Dental University, Tokyo, Japan Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging

100277 3-H-W41-5-P Natsumi Kikuchi Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan The roles of ILC3 and &gamma;&delta; T cells in the development of colitis of the model-mice

100305 3-H-W41-6-P Shigeki Sakai Department of Medicine, Shiga University of Medical Science, Shiga, JapanBortezomib suppresses the development of experimental colitis by inhibiting the activation of NF-

&kappa;B

100310 3-H-W41-7-P Miki Matsui Department of Pharmacology, Kyoto Pharmaceutical University, Kyoto, Japan

The role of Ca<sup>2+</sup>-activated K<sup>+</sup> channel K<sub>Ca</sub>3.1 in mesenteric

lymph node CD4<sup>+ </sup>T cells of chemically-induced murine inflammatory bowel disease

model

100215 3-H-W41-8-P Taizo MoriDepartment of Immune Regulation, The Research Center for Hepatitis and

Immunology, Research Institute, National Center for Global Health and MedicineLnk/Sh2b3 regulates adipose inflammation and glucose tolerance through group1-ILCs

100385 3-H-W41-9-O/P Kota NishihamaMie University Graduated School of Medicine, Diabetes, Metabolism and

Endocrinology, Tsu, JapanAnti-diabetic effect of matrix metalloproteinase-2 and its correlation with protein S in diabetes

100401 3-H-W41-10-P Taro Yasuma Department of Immunology, Mie University Graduate School of MedicineProtein S inhibits apoptosis of pancreatic &beta; cells by regulating BIRC3 expression and AKT

signaling

100415 3-H-W41-11-O/P Atsuro TakeshitaDiabetes, Metabolism and Endocrinology, Mie University Graduate School of Medicine,

Tsu, JapanProtein S reduces the progression of diabetic nephropathy in mice

100649 3-H-W41-12-P Takeru Ihara Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University The role of signal-transducing adaptor protein-1 in Concanavalin A-induced hepatitis

100330 3-H-W41-13-O/P Yosuke KurashimaDivision of Mucosal Immunology, Department of Microbiology and Immunology, The

Institute of Medical Science, The University of Tokyo, Tokyo, Japan

<strong>Mesenchymal-myeloid cell interactions in renal microenvironment for pathological fibrogenic

machinery in kidney fibrosis</strong>

100638 3-H-W41-14-O/P Naoto Sasaki Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, JapanUltraviolet B exposure prevents atherosclerotic cardiovascular disease by regulating

immunoinflammatory responses

100492 3-H-W41-15-O/P Akira TaruyaDepartment of Cardiovascular Medicine, Wakayama Medical University, Wakayama,

JapanDecline of lysyl oxidase protein causes acute aortic dissection in Spi-B knockout mice

100437 3-H-W41-16-O/P Tomonori Kaifu Department of Immunology, Tohoku Medical and Pharmaceutical University DCIR negatively regulates osteoclastogenesis by binding to a novel endogenous ligand

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W39Systemic autoimmune

disease (3)

Dec. 14

(Thu.), 2017

W40 Granulocyte & Mast cellsDec. 14

(Thu.), 2017

W41Tissue-specific immune

diseases III

Dec. 14

(Thu.), 2017

12 / 13

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The 46th Annual Meeting of The Japanese Society for Immunology Program for Poster

Session Title Date Time Submission ID Program No. 1st Author Affiliation Abstract Title

100561 3-I-W42-1-P Manabu InobeInstitute of Medical, Pharmaceutical and Health Sciences, Kanazawa University,

Kanazawa, Japan

CD8<sup>+</sup> T cells are less dependent on Erk to proliferate compared with CD4<sup>+</sup>

T cells

100194 3-I-W42-2-P Saitoh KodaiDepartment of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University,

Hokkaido, JapanA role of STAP-2 in T cell activation and T cell-mediated immune responses

100518 3-I-W42-3-P Matsui YukihideDepartment of molecular immunology, the faculty of medicine, Toho University, Tokyo,

JapanTCR-stimulation recruits CBP from nucleus to the cytoplasm and affects the protein phosphorylation

100609 3-I-W42-4-O/P Ryunosuke Muro Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, JapanControl of proinflammatory &gamma;&delta;T cell development by linage-specific TCR signaling

pathway

100015 3-I-W42-5-O/P Honglian TongDivision of Molecular and Cellular Immunoscience, Department of Biomolecular

Sciences, Faculty of Medicine, Saga University, Saga, Japan

Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-

stimulated T cells

100391 3-I-W42-6-O/P Takayuki ImanishiRIKEN Center for Integrative Medical Sciences (IMS) Laboratory for Cell Signaling,

Yokohama, JapanTCR-signals control STING-mediated type 1 IFN responses in T cells

100449 3-I-W42-7-P OGAWA ShuheiDivision of Immunobiology, Research Institute for Biomedical Sciences, Tokyo

University of ScienceThe regulation of CD28 tyrosine phosphorylation and the function of CD28-mediated costimulation.

100049 3-I-W42-8-P Kaoru ToshimaDivision of Glycopathology, Institute of Molecular Biomembrane and Glycobiology,

Tohoku Medical and Pharmaceutical University, Miyagi, JapanSphingomyelin is involved in TCR-induced apoptosis in thymocyte development

100178 3-I-W42-9-O/P Eun Jeong Park Mie University Graduate School of Medicine, Mie, Japan &beta;7 integrin-mediated homing of exosomes to the gut

100594 3-I-W42-10-O/P Yuji KamiokaDepartment of Molecular Genetics, Institute of Biomedical Science, Kansai Medical

University, Osaka, JapanRoles of Rap1 and Kindlin-3 in lymphocyte homing to peripheral lymph nodes

100417 3-I-W42-11-O/P Tsuyoshi Sato Department of Biosciences, School of Science, Kitasato University, kanagawa, Japan T cell specific Rap1-deficient mice develop spontaneous colitis

100461 3-I-W42-12-O/P Naoyuki Kondo Kansai medical university, Hirakata, Osaka, Japan NDR1 acts as a molecular hub for the organization of immunological synapse

100439 3-I-W42-13-P Kenta IwasakiDepartment of Kidney Disease and Transplant Immunology, Aichi Medical University

School of Medicine, Aichi, Japan

Differential response of allo-reactive CD4 T-cells against HLA class II expressed on endothelial cells in

the presence of HLA and ABO antibody.

100478 3-I-W42-14-O/P Akiko Hashimoto-Tane RIKEN Center for Integrative Medical Science, Yokohama, Japan Molecular assembly and function of PTPN22 in T cell receptor signaling

100652 3-I-W42-15-P Hiroaki Machiyama Deparment of Immunology, Tokyo Medical University, Tokyo, Japan TCR signaling introduces endocytic machineries at the microclusters

100521 3-I-W42-16-P Koji Eshima Kitasato University School of MedicineImplication of T-bet, the master regulator of Th1 cells, in the cytotoxicity of murine CD4<sup>+</sup> T

cells

100657 3-I-W42-17-P Hiroki YatsuDivision of Molecular Pathology, Research Institute for Biomedical Science, Tokyo

University of Science, Noda, Japan

Regulation Mechanism of Differentiation in Type 1 Helper T cell (T<sub>H</sub>1) and Follicular

Helper T cell (T<sub>FH</sub>) Specific for Influenza A Virus

100187 3-I-W43-1-O/P Jisu MaDepartment of Immunoparasitology, Research Institute for Microbial Diseases, Osaka

University, Osaka, Japan

<strong>PLC&beta; plays an important role in CD8 T cell-mediated host defense against

<em>Toxoplasma gondii</em></strong>

100556 3-I-W43-2-P Yuki TABATA Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan<strong>IL-2 production is negatively regulated by free fatty acid receptor 2 (Ffar2) mediated

signaling.</strong>

100557 3-I-W43-3-P Masanobu KimuraDepartment of Microbiology and Immunology, Tohoku University Graduate School of

Medicine, Sendai, Japan

<strong>TRAF2 and TRAF5 binding to the signal transducing receptor gp130 inhibit JAK1 activation in

the IL-6-receptor signaling complex</strong>

100211 3-I-W43-4-P Tomohiro Masuda 名古屋市昭和区 Growth factor Midkine promotes NFAT activation and Th1 differentiation in lupus Nephritis

100059 3-I-W43-5-O/P Akihiro Shimba Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan Glucocorticoids drive diurnal changes in distibution and response of T cells via IL-7 receptor expression

100074 3-I-W43-6-P Guangwei CuiLaboratory of Immune Regulation, Institute for Frontier Life and Medical Sciences,

Kyoto University, Kyoto, Japan

Competition between STAT5 and PI3K of the IL-7R modulates T cell and type 2 ILC development in

vivo

100505 3-I-W43-7-P Shizue Tani-ichi Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan Exploring the signals upregulating IL-7R&alpha; expression via NF&kappa;B activation in T cells

100262 3-I-W43-8-O/P Mohammad A SAYEMDivision of Cellular Signaling, Advanced Institute of Medical Research, Keio University

School of Medicine, Tokyo, Japan

<strong>IL-8 has a negative role on tumor infiltrating CD8<sup>+</sup> T cells in various

cancers</strong>

100051 3-I-W43-9-P Ryoyo IkebuchiLaboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University,

Tondabayashi, Osaka, Japan

Single-cell gene and protein expression analysis revealed functional and migratory heterogeneity in

regulatory T cells of inflamed skin

100615 3-I-W43-10-P Yoichi MaekawaDepartment of Parasitology and Infectious Diseases, Gifu University Graduate School

of Medicine, Gifu, JapanThe immune responses of CD4<sup>+</sup> T cells are affected by hypergravity

100563 3-I-W43-11-O/P Akio OhtaDepartment of Molecular Medicine, Foundation for Biomedical Research and

Innovation, Kobe, JapanTransient hypoxia persistently inhibits T cell activation

100152 3-I-W43-12-P Yumiko KannoDepartment of Immunology, Dokkyo Medical University School of Medicine, Mibu,

Shimotsuga, Tochigi, Japan

HIF-1&alpha; plays a key role in regulation of homeostatic energy metabolism in cytotoxic T

lymphocytes.

100022 3-I-W43-13-O/P Junpei SuzukiDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime

University Graduate School of Medicine, Ehime, Japan

<strong>The tumor suppressor menin epigenetically regulates CD8 T cell senescence via the

modulation of glutamine metabolism</strong>

100582 3-I-W43-14-O/P Hisako AkatsukaDepartment of Host Defense Mechanism, Tokai University School. of Medicine,

Kanagawa Japan

AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through ATG7-independent

pathway

100140 3-I-W43-15-O/P Michio MiyajimaLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN

Yokohama Institute, Yokohama, Japan

Systemic metabolic shift induced by PD-1 deficiency perturbs brain monoamines and emotional

behaviour

100112 3-I-W43-16-P Ruka Setoguchi RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan<strong>Impairment of memory CD8 T cell maintenance in MHC class II deficient mice is caused by

inflammation not by CD4 T cell deficiency</strong>

100414 3-I-W43-17-O/P Harumichi IahigameLaboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences,

Kanagawa, Japan

<strong>Developmental plasticity of KLRG1<sup>+</sup> effector CD8<sup>+</sup> T cells

promotes protective immunity</strong>

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