BIOHELLENIKA SERVICES

PLATELET RICH PLASMA(PRP)

1.

Platelet Rich Plasma (PRP) is an autologous advanced �Minimal discomfort: reduces the pain duration much skin rejuvenation product derived from patient's own faster blood as a serum enriched with growth factors from

�Shorten downtime: faster stimulation of healing platelets and bioactive proteins that induce cell growth process and regeneration. This personalized serum aims to

stimulate collagen and elastin production of the skin �Cost Effective: the cost is lower compared to

fibroblasts, both molecules fill the desired areas. After a alternative treatments

specific process, patient's blood results to a PRP serum, a natural anti-aging solution very beneficial to skin �Simple procedure rejuvenation. Also, PRP eliminates acne scars and

�Long lasting result: rejuvenation lasts for a longer minimize skin pores leaving your skin smoother and period of time comparing with other fillersyounger.

�Not causes trauma Platelet Rich Plasma is an increasingly popular method as it is the ideal collagen and elastin stimulating therapy for treating ageing skin of face, neck, eyes, hands and décolletage by improving texture, tone, fine lines and wrinkles, helping it to become progressively thicker, tighter and suppler.

Benefits of PRP TherapyPRP method has many advantages such as:

�Natural result without the risk of 'looking done' or asymmetry

�No risk of transmissible infection, rejection, allergic reaction or allergy (100% your own blood by-product)

PRP

AESTHETICS

VETERINARY PLASTICSURGERY

ORTHOPEDICS

DENTISTRY

OPHTHALMOLOGY

PLATELET RICH PLASMA(PRP)

1.

Platelet Rich Plasma (PRP) is an autologous advanced �Minimal discomfort: reduces the pain duration much skin rejuvenation product derived from patient's own faster blood as a serum enriched with growth factors from

�Shorten downtime: faster stimulation of healing platelets and bioactive proteins that induce cell growth process and regeneration. This personalized serum aims to

stimulate collagen and elastin production of the skin �Cost Effective: the cost is lower compared to

fibroblasts, both molecules fill the desired areas. After a alternative treatments

specific process, patient's blood results to a PRP serum, a natural anti-aging solution very beneficial to skin �Simple procedure rejuvenation. Also, PRP eliminates acne scars and

�Long lasting result: rejuvenation lasts for a longer minimize skin pores leaving your skin smoother and period of time comparing with other fillersyounger.

�Not causes trauma Platelet Rich Plasma is an increasingly popular method as it is the ideal collagen and elastin stimulating therapy for treating ageing skin of face, neck, eyes, hands and décolletage by improving texture, tone, fine lines and wrinkles, helping it to become progressively thicker, tighter and suppler.

Benefits of PRP TherapyPRP method has many advantages such as:

�Natural result without the risk of 'looking done' or asymmetry

�No risk of transmissible infection, rejection, allergic reaction or allergy (100% your own blood by-product)

PRP

AESTHETICS

VETERINARY PLASTICSURGERY

ORTHOPEDICS

DENTISTRY

OPHTHALMOLOGY

PLATELET RICH PLASMA(PRP)

PRP APPLICATIONS – CLINICAL AREAS

Today Platelet Rich Plasma is used to:

Manage your skin age…

a radiant and fresh look just for you

�rejuvenate facial skin (including nasolabial lines,

marionette lines, forehead lines), neck – chest –

décolletage aging

�improve the texture of the skin, fine lines, wrinkles,

especially around and under the eyes and neck

�improve the quality of aging skin

�correct acne or other scars

�post skin laser treatment

�improve stretch mark

�back of hands and arms reduce hair loss, strengthen

hair roots and nourish hair follicles

AESTHETICS

PLASTIC SURGERY

Platelet Rich Plasma stimulates angiogenesis, promoting

vascular growth and fibroblast proliferation. In addition,

PRP functions as haemostatic by forming a fibrin clot.

Also application of PRP enhances wound-healing in both

soft and hard tissue.

Biohellenika has developed autologous therapeutic

products for the healing of:

�pressure sores

�diabetic ulcers

�burns

�wounds

Hair loss

Fine lines and wrinkles around and under the eyes

Wound and scar healing

Cheeks and entire face

Hand and arms

Jaw

Neck

Chest and décolletage

Loose skin & skin tone

Hand and arms

Other body areas

PLATELET RICH PLASMA(PRP)

PRP APPLICATIONS – CLINICAL AREAS

Today Platelet Rich Plasma is used to:

Manage your skin age…

a radiant and fresh look just for you

�rejuvenate facial skin (including nasolabial lines,

marionette lines, forehead lines), neck – chest –

décolletage aging

�improve the texture of the skin, fine lines, wrinkles,

especially around and under the eyes and neck

�improve the quality of aging skin

�correct acne or other scars

�post skin laser treatment

�improve stretch mark

�back of hands and arms reduce hair loss, strengthen

hair roots and nourish hair follicles

AESTHETICS

PLASTIC SURGERY

Platelet Rich Plasma stimulates angiogenesis, promoting

vascular growth and fibroblast proliferation. In addition,

PRP functions as haemostatic by forming a fibrin clot.

Also application of PRP enhances wound-healing in both

soft and hard tissue.

Biohellenika has developed autologous therapeutic

products for the healing of:

�pressure sores

�diabetic ulcers

�burns

�wounds

Hair loss

Fine lines and wrinkles around and under the eyes

Wound and scar healing

Cheeks and entire face

Hand and arms

Jaw

Neck

Chest and décolletage

Loose skin & skin tone

Hand and arms

Other body areas

PLATELET RICH PLASMA(PRP)

DENTISTRY

Platelet rich plasma enhances bone regeneration. PRP applications were first developed in veterinary Biohellenika is one of the pioneers that developed a new medicine and now is used for approach to apply PRP

�tendon and ligament injuries�bone graft for closure clefts, lips, fistulas and palate

�wound healing defects

�osteoarthritis �repair bone defects after tooth or cysts extraction

�implant in the dental surgery1. Treatment With Platelet-Rich Plasma Is More Effective Than Placebo

for Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Trial.

Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A.Am J Sports Med. 2013.

PRP's growth factors quicken the recovery of corneal 2. A Novel Method For Iatrogenic Vesicovaginal Fistula Treatment: Autologous Platelet-Rich-Plasma Injection And Platelet-Rich-Fibrin-epithelial cells, shorten the recovery of surgical area by Glue Interposition.carrying out anti-inflammatory activity, minimize post-Shirvan MK, Alamdari DH, Ghorifi A. J Urol. 2012 Dec 28 surgery pain and stabilize the corrected eyesight by

stimulated healing.

�epithelial defects

�trauma of the cornea

�dry eye syndrome

�post laser surgery syndrome

OPTHALMOLOGY

VETERINARY ORTHOPEDICS

The earlier treatment, the better outcome

Except the natural process of ageing, our life itself Platelet Rich Plasma (PRP) is a 100% non surgical natural includes injuries, traumas and pain. PRP is very effective treatment for pain and injury. PRP is injected directly to in treating osteoarthritis, especially in early stages. PRP the site of injury trigging body's nature to repair itself in a stimulates cartilage regeneration inhibiting the drug-free way within a short recovery time for most deterioration effects of age and slows the development patients.of arthritis.

Biohellenika owns innovative technology and products to

enhance soft and bone tissue healing.

Most common applications

�cartilage/ligament repair

�osteoarthritis

�tendonitis

�post-operative pain

�inflammation reduction

�chronic pain

Natural Therapy, No Side Effects

Avoid Major Surgery! Heal More Rapidly

PLATELET RICH PLASMA(PRP)

DENTISTRY

Platelet rich plasma enhances bone regeneration. PRP applications were first developed in veterinary Biohellenika is one of the pioneers that developed a new medicine and now is used for approach to apply PRP

�tendon and ligament injuries�bone graft for closure clefts, lips, fistulas and palate

�wound healing defects

�osteoarthritis �repair bone defects after tooth or cysts extraction

�implant in the dental surgery1. Treatment With Platelet-Rich Plasma Is More Effective Than Placebo

for Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Trial.

Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A.Am J Sports Med. 2013.

PRP's growth factors quicken the recovery of corneal 2. A Novel Method For Iatrogenic Vesicovaginal Fistula Treatment: Autologous Platelet-Rich-Plasma Injection And Platelet-Rich-Fibrin-epithelial cells, shorten the recovery of surgical area by Glue Interposition.carrying out anti-inflammatory activity, minimize post-Shirvan MK, Alamdari DH, Ghorifi A. J Urol. 2012 Dec 28 surgery pain and stabilize the corrected eyesight by

stimulated healing.

�epithelial defects

�trauma of the cornea

�dry eye syndrome

�post laser surgery syndrome

OPTHALMOLOGY

VETERINARY ORTHOPEDICS

The earlier treatment, the better outcome

Except the natural process of ageing, our life itself Platelet Rich Plasma (PRP) is a 100% non surgical natural includes injuries, traumas and pain. PRP is very effective treatment for pain and injury. PRP is injected directly to in treating osteoarthritis, especially in early stages. PRP the site of injury trigging body's nature to repair itself in a stimulates cartilage regeneration inhibiting the drug-free way within a short recovery time for most deterioration effects of age and slows the development patients.of arthritis.

Biohellenika owns innovative technology and products to

enhance soft and bone tissue healing.

Most common applications

�cartilage/ligament repair

�osteoarthritis

�tendonitis

�post-operative pain

�inflammation reduction

�chronic pain

Natural Therapy, No Side Effects

Avoid Major Surgery! Heal More Rapidly

2.AUTOLOGOUS CONDITIONED SERUM (ACS)

Today's applications show that its most common uses are phalangeal joints, knee, shoulder, muscular injury in in osteoarthritis, especially in the knee and the hip joint athletes and the sciatica and lumbar back pain. area. As people mature, the percentage of the population

Although osteoarthritis can't be cured yet, symptoms can that suffers from osteoarthritis increases. A special be treated effectively and degenerative process will be messenger, the protein interleukin-1 (IL-1) plays an delayed. The Autologous Condition Serum enhances essential role in the development of osteoarthritis. It body's natural defense mechanisms against promotes joint and cartilage inflammation that leads to inflammation, reduces pain, improves function and pain.promotes natural healing. A safe, simple and effective

This protective protein called interleukin-1 receptor treatment.antagonist (IL-1Ra) suppresses the aggressive IL-1 and thus acts anti-inflammatory, analgesic and cartilage- Concerns All of Us for a New Lifetimeprotective.

Except the natural aging process, other factors such as overweight, genetic predisposition, injuries lead to pain, severity of osteoarthritis and loss of mobility.

Beneficiary Effect on Osteoarthritis

A unique natural medical procedure in which an autologous blood product is introduced to the patient's body to reduce chronic pain, osteoarthritis and treat arthritis of the elbow, antebrachiocarpal joints, tarsi,

applications. The younger age the fibroblasts, the better Discover YOUTH a revolutionary personalized cell

results. So, we advise that fibroblasts should be product using your own fibroblasts for face rejuvenation

preserved in young ages. Fibroblasts injection usually is Fibroblasts, the richest source of collagen and elastin, are

combined with PRP for even better results.widely spread cells in the body, especially in dermis. Aging

decreases all biological activities of fibroblasts like cell

proliferation and secretion of extracellular matrix

components, thus the skin ages.

YOUTH, composed by pure autologous fibroblasts,

improves the appearance of your skin. Its implantation

enriches the skin with activated cells that produce

collagen and elastin for long term rejuvenation of the

skin. Fibroblasts are extracted from a small skin biopsy,

cultured in Biohellenika's laboratories to reach an

adequate number, activated by a low energy laser and

injected into the wrinkles and the imperfections of the

face.

Effective and Simple

YOUTH is prepared especially for you!!! The method is

safe without any risk, no complications but with long term

results. The fibroblasts can be cryopreserved in

separated vials and used in more than once future

3.KEEP YOR JUVENILENESS FOR EVER

2.AUTOLOGOUS CONDITIONED SERUM (ACS)

Today's applications show that its most common uses are phalangeal joints, knee, shoulder, muscular injury in in osteoarthritis, especially in the knee and the hip joint athletes and the sciatica and lumbar back pain. area. As people mature, the percentage of the population

Although osteoarthritis can't be cured yet, symptoms can that suffers from osteoarthritis increases. A special be treated effectively and degenerative process will be messenger, the protein interleukin-1 (IL-1) plays an delayed. The Autologous Condition Serum enhances essential role in the development of osteoarthritis. It body's natural defense mechanisms against promotes joint and cartilage inflammation that leads to inflammation, reduces pain, improves function and pain.promotes natural healing. A safe, simple and effective

This protective protein called interleukin-1 receptor treatment.antagonist (IL-1Ra) suppresses the aggressive IL-1 and thus acts anti-inflammatory, analgesic and cartilage- Concerns All of Us for a New Lifetimeprotective.

Except the natural aging process, other factors such as overweight, genetic predisposition, injuries lead to pain, severity of osteoarthritis and loss of mobility.

Beneficiary Effect on Osteoarthritis

A unique natural medical procedure in which an autologous blood product is introduced to the patient's body to reduce chronic pain, osteoarthritis and treat arthritis of the elbow, antebrachiocarpal joints, tarsi,

applications. The younger age the fibroblasts, the better Discover YOUTH a revolutionary personalized cell

results. So, we advise that fibroblasts should be product using your own fibroblasts for face rejuvenation

preserved in young ages. Fibroblasts injection usually is Fibroblasts, the richest source of collagen and elastin, are

combined with PRP for even better results.widely spread cells in the body, especially in dermis. Aging

decreases all biological activities of fibroblasts like cell

proliferation and secretion of extracellular matrix

components, thus the skin ages.

YOUTH, composed by pure autologous fibroblasts,

improves the appearance of your skin. Its implantation

enriches the skin with activated cells that produce

collagen and elastin for long term rejuvenation of the

skin. Fibroblasts are extracted from a small skin biopsy,

cultured in Biohellenika's laboratories to reach an

adequate number, activated by a low energy laser and

injected into the wrinkles and the imperfections of the

face.

Effective and Simple

YOUTH is prepared especially for you!!! The method is

safe without any risk, no complications but with long term

results. The fibroblasts can be cryopreserved in

separated vials and used in more than once future

3.KEEP YOR JUVENILENESS FOR EVER

BenefitsMy Cream is a sur mesure revolutionary anti-aging

product based on the latest discoveries in stem cell �Firmer and smoother skin

research. This advanced formula completely restores �Reduction of fine lines and wrinklesskin's youth, diminishes wrinkles, reverses skin damage

and minimizes visible signs of aging. �Plumper skin

My cream contains high-tech ingredients using the self-�Deeply hydrated skin

renew abilities of stem cells promoting firmness and

elasticity leaving skin smoother and younger-looking.

ApplicationMy Cream, since autologous, is personalized for each

individual according to the skin type and age. Apply My cream twice a day (morning & evening) after

cleansing. Gently massage in until the cream is absorbed.

Size: 30mlTwo Products To Try

Two types of My Cream are available containing a

unique anti-aging cream base enriched with two different

skincare extracts supporting skin's natural repair process.

For the first type, the base is mixed with autologous PRP

and for the second we mix the supernatant of the

autologous mesenchymal stem cell cultures and the

cream base. Both types help cell renewal, have incredible

nourishing abilities and prevent the skin from aging

prematurely.

4.MY CREAM

BenefitsMy Cream is a sur mesure revolutionary anti-aging

product based on the latest discoveries in stem cell �Firmer and smoother skin

research. This advanced formula completely restores �Reduction of fine lines and wrinklesskin's youth, diminishes wrinkles, reverses skin damage

and minimizes visible signs of aging. �Plumper skin

My cream contains high-tech ingredients using the self-�Deeply hydrated skin

renew abilities of stem cells promoting firmness and

elasticity leaving skin smoother and younger-looking.

ApplicationMy Cream, since autologous, is personalized for each

individual according to the skin type and age. Apply My cream twice a day (morning & evening) after

cleansing. Gently massage in until the cream is absorbed.

Size: 30mlTwo Products To Try

Two types of My Cream are available containing a

unique anti-aging cream base enriched with two different

skincare extracts supporting skin's natural repair process.

For the first type, the base is mixed with autologous PRP

and for the second we mix the supernatant of the

autologous mesenchymal stem cell cultures and the

cream base. Both types help cell renewal, have incredible

nourishing abilities and prevent the skin from aging

prematurely.

4.MY CREAM

1. Mosna F, Sensebé L, Krampera M. Mesenchymal stem cells are collected from adipose Human bone marrow and adipose tissue mesenchymal stem cells: a tissue after liposuction and are used for cosmetic and user's guide.

regenerative medicine applications. Adipose tissue Stem Cells Dev. 2010 Oct;19(10):1449-70.

contains a fraction of stem cells, 1.000 times more than 2. Rada T, Reis RL, Gomes ME.

Adipose tissue-derived stem cells and their application in bone and other source. The fraction contains perivascular cartilage tissue engineering.

mesenchymal stem cells from the vessels of TissueEng Part B Rev. 2009 Jun;15(2):113-25.

microcirculation, vascular endothelial and proendothelial 3. Zhen G, Liu H, Gu N, Zhang H, Xu Y, Zhang Z.

stem cells and mature fibroblasts. In cosmetic medicine, Mesenchymal stem cells transplantation protects against rat pulmonary emphysema.mesenchymal cells are used for face reconstruction Front Biosci. 2008 May 1;13:3415-22.

combined with PRP, to treat wrinkles and skin 4. Griffin M, Iqbal SA, Bayat A.

rejuvenation. Also, mesenchymal cells are used to treat Exploring the application of mesenchymal stem cells in bone repair and regeneration.autoimmune diseases, like multiple sclerosis, Crohn's J Bone Joint Surg Br. 2011 Apr;93(4):427-34. disease, ulcerative colitis, rheumatoid arthritis and newly

diagnosed diabetes type I. Also are used to treat chronic

pulmonary obstruction, osteoarthritis (traumatic or

degenerated), fractures, diabetic ulcers and burns.

5.MESENCHYMAL STEM CELLS FOR COSMETICS OR REGENERATIVE MEDICINE

Clinical applications: 3. Autologous chondrocytes implantation. This

method is applied to young patients in the cases of 1. Cartilage rejuvenation (simple incidents). sports injury and not to elder patients, because the

Mesenchymal stem cells modification to ability of chondrocytes to proliferate is decreased chondrocytes. Biohellenika has developed an during the age. A small biopsy of the healthy part of innovative technology to isolate, purify and regenerate the cartilage is removed and the chondrocytes are the patient's own chondroblasts and chondrocytes for separated after enzymatic digestion. The either intrarticular or arthroscopic re-injection. In the chondrocytes are proliferated and since an adequate case of osteoarthritis at any age, mesenchymal cells number of cells, according to the extent of injury,is extracted from adipose tissue modified to accomplished they are implanted into the damaged chondrocytes and with minimal invasive endoscopy area, in a three dimensional sticky gel of fibrin glue. applied into the damaged cartilage. The number of This method is applied in the cases of cartilage loss of

2injected cells is analogous to the extent of the damage. over 8cm . The cartilage reconstruction is applied in all

genders, age 15-60 years old, for damaged areas 2 ranging from 1.6 to 12 cm and in athletes of all sports.

Autologous chondroblasts or chondrocytes 2. Cartilage rejuvenation (for high cartilage loss-preparation treatments are compliant with current heavy incidents). Mesenchymal stem cells European Parliament and of the council of 13 modification to chondrocytes. Adipose tissue November 2007 on: Advanced therapy medicinal derived stem cells cultured and differentiated into products and amending Directive 2001/83/EC and chondrocytes,implanted in three dimensionalscaffold Regulation (EC) No 726/20042.and infused arthroscopically, for cartilage loss over 3-

24 cm .

1. Mosna F, Sensebé L, Krampera M. Mesenchymal stem cells are collected from adipose Human bone marrow and adipose tissue mesenchymal stem cells: a tissue after liposuction and are used for cosmetic and user's guide.

regenerative medicine applications. Adipose tissue Stem Cells Dev. 2010 Oct;19(10):1449-70.

contains a fraction of stem cells, 1.000 times more than 2. Rada T, Reis RL, Gomes ME.

Adipose tissue-derived stem cells and their application in bone and other source. The fraction contains perivascular cartilage tissue engineering.

mesenchymal stem cells from the vessels of TissueEng Part B Rev. 2009 Jun;15(2):113-25.

microcirculation, vascular endothelial and proendothelial 3. Zhen G, Liu H, Gu N, Zhang H, Xu Y, Zhang Z.

stem cells and mature fibroblasts. In cosmetic medicine, Mesenchymal stem cells transplantation protects against rat pulmonary emphysema.mesenchymal cells are used for face reconstruction Front Biosci. 2008 May 1;13:3415-22.

combined with PRP, to treat wrinkles and skin 4. Griffin M, Iqbal SA, Bayat A.

rejuvenation. Also, mesenchymal cells are used to treat Exploring the application of mesenchymal stem cells in bone repair and regeneration.autoimmune diseases, like multiple sclerosis, Crohn's J Bone Joint Surg Br. 2011 Apr;93(4):427-34. disease, ulcerative colitis, rheumatoid arthritis and newly

diagnosed diabetes type I. Also are used to treat chronic

pulmonary obstruction, osteoarthritis (traumatic or

degenerated), fractures, diabetic ulcers and burns.

5.MESENCHYMAL STEM CELLS FOR COSMETICS OR REGENERATIVE MEDICINE

Clinical applications: 3. Autologous chondrocytes implantation. This

method is applied to young patients in the cases of 1. Cartilage rejuvenation (simple incidents). sports injury and not to elder patients, because the

Mesenchymal stem cells modification to ability of chondrocytes to proliferate is decreased chondrocytes. Biohellenika has developed an during the age. A small biopsy of the healthy part of innovative technology to isolate, purify and regenerate the cartilage is removed and the chondrocytes are the patient's own chondroblasts and chondrocytes for separated after enzymatic digestion. The either intrarticular or arthroscopic re-injection. In the chondrocytes are proliferated and since an adequate case of osteoarthritis at any age, mesenchymal cells number of cells, according to the extent of injury,is extracted from adipose tissue modified to accomplished they are implanted into the damaged chondrocytes and with minimal invasive endoscopy area, in a three dimensional sticky gel of fibrin glue. applied into the damaged cartilage. The number of This method is applied in the cases of cartilage loss of

2injected cells is analogous to the extent of the damage. over 8cm . The cartilage reconstruction is applied in all

genders, age 15-60 years old, for damaged areas 2 ranging from 1.6 to 12 cm and in athletes of all sports.

Autologous chondroblasts or chondrocytes 2. Cartilage rejuvenation (for high cartilage loss-preparation treatments are compliant with current heavy incidents). Mesenchymal stem cells European Parliament and of the council of 13 modification to chondrocytes. Adipose tissue November 2007 on: Advanced therapy medicinal derived stem cells cultured and differentiated into products and amending Directive 2001/83/EC and chondrocytes,implanted in three dimensionalscaffold Regulation (EC) No 726/20042.and infused arthroscopically, for cartilage loss over 3-

24 cm .

Bone marrow is the part of the body that produces the

hematopoietic stem cells and all the mature blood

elements. Bone marrow transplantation is a medical

procedure whose aim is to replace unhealthy blood stem

cells with healthy in order to treat a blood malignant or

inherited disease.

Bone marrow is selected by iliac crest aspiration and is a

rich source of hematopoietic and mesenchymal stem

cells.

This product is also used to treat solid malignant tumors

or in regenerative medicine.

6. 7.BONE MARROW STEM CELLS

DENTAL PULP MESENCHYMAL STEM CELLS

Mesenchymal stem cells from the dental pulp have the The interaction of mesenchymal stem cells with PRP is a potential to differentiate into a variety of cell types. promising tool for their therapeutic use in:

Several publications show their importance in tissue regeneration due to the unique characteristics they demonstrated such as proliferation, differentiation and plasticity.

Advantages

�Easy & noninvasive procedure

�Safe cryopreservation

�Extensive proliferation

�Long lifespan

�Highly efficient

�Maximum regenerative ability

Biohellenika developed an innovative technology to bank stem cells from teeth for people to secure their future health.

�

�Regenerative medicine of

many organs like:

�Nerve & spinal cord

�Brain

�Heart

�Liver

�Bone

�Ligaments

and cartilage

�Muscle

�Skin

Regenerative dentistry

ChlidrenDeciduous

teeth

AdultsWisdom

teeth

Mesenchymal Stem Cells

Bone marrow is the part of the body that produces the

hematopoietic stem cells and all the mature blood

elements. Bone marrow transplantation is a medical

procedure whose aim is to replace unhealthy blood stem

cells with healthy in order to treat a blood malignant or

inherited disease.

Bone marrow is selected by iliac crest aspiration and is a

rich source of hematopoietic and mesenchymal stem

cells.

This product is also used to treat solid malignant tumors

or in regenerative medicine.

6. 7.BONE MARROW STEM CELLS

DENTAL PULP MESENCHYMAL STEM CELLS

Mesenchymal stem cells from the dental pulp have the The interaction of mesenchymal stem cells with PRP is a potential to differentiate into a variety of cell types. promising tool for their therapeutic use in:

Several publications show their importance in tissue regeneration due to the unique characteristics they demonstrated such as proliferation, differentiation and plasticity.

Advantages

�Easy & noninvasive procedure

�Safe cryopreservation

�Extensive proliferation

�Long lifespan

�Highly efficient

�Maximum regenerative ability

Biohellenika developed an innovative technology to bank stem cells from teeth for people to secure their future health.

�

�Regenerative medicine of

many organs like:

�Nerve & spinal cord

�Brain

�Heart

�Liver

�Bone

�Ligaments

and cartilage

�Muscle

�Skin

Regenerative dentistry

ChlidrenDeciduous

teeth

AdultsWisdom

teeth

Mesenchymal Stem Cells

STEM CELLS FROM UMBILICAL CORD-PLACENTA UNIT

1. Hematopoietic Umbilical Cord BloodStem Cells. 3. Wharton's Jelly Mesenchymal Cells. Biohellenika

After the ligation of the umbilical cord the placenta developed a patent for a unique and innovative

blood is collected in a blood bag via umbilical cord vein method to collect mesenchymal stem cells from the

puncture. Cord blood contains hematopoietic stem umbilical cord. The main advantages of this method

cells with clinical applications for malignant diseases are the highest number of collected cells, the cost

for more than 20 years. Over 25.000 cord blood effectiveness and a ready to use product. The cells are

hematopoietic stem cells transplantations have been collected from the total length of the cord and

referred until today. cryopreserved in more than of one vials, so there is no

need to proliferate and the cells maintain the 2. Hematopoietic Stem Cells from Placenta stemness and all biological activities during the

Drainage. Many stem cells remain in the placenta storage.

after puncturing the umbilical vein, because of the

The cell therapies are safe because the cells are structure of the placenta and the conditions of birth. In

autologous (patient's own cells), the procedures are the emergencies during the delivery, the volume of the

minimally invasive with short recovery time for the collected placenta blood is low and the drainage of the

patient but with long-lasting results. placenta offers double amount of cells. The stem cells

that are collected by this procedure are enriched in

hematopoietic stem sells, endothelia and pro

endothelia cells and are proposed to improve

angiogenesis after coronary artery occlusion.

8.

STEM CELLS FROM UMBILICAL CORD-PLACENTA UNIT

1. Hematopoietic Umbilical Cord BloodStem Cells. 3. Wharton's Jelly Mesenchymal Cells. Biohellenika

After the ligation of the umbilical cord the placenta developed a patent for a unique and innovative

blood is collected in a blood bag via umbilical cord vein method to collect mesenchymal stem cells from the

puncture. Cord blood contains hematopoietic stem umbilical cord. The main advantages of this method

cells with clinical applications for malignant diseases are the highest number of collected cells, the cost

for more than 20 years. Over 25.000 cord blood effectiveness and a ready to use product. The cells are

hematopoietic stem cells transplantations have been collected from the total length of the cord and

referred until today. cryopreserved in more than of one vials, so there is no

need to proliferate and the cells maintain the 2. Hematopoietic Stem Cells from Placenta stemness and all biological activities during the

Drainage. Many stem cells remain in the placenta storage.

after puncturing the umbilical vein, because of the

The cell therapies are safe because the cells are structure of the placenta and the conditions of birth. In

autologous (patient's own cells), the procedures are the emergencies during the delivery, the volume of the

minimally invasive with short recovery time for the collected placenta blood is low and the drainage of the

patient but with long-lasting results. placenta offers double amount of cells. The stem cells

that are collected by this procedure are enriched in

hematopoietic stem sells, endothelia and pro

endothelia cells and are proposed to improve

angiogenesis after coronary artery occlusion.

8.

www.biohellenika.gr

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T: 00357 22.028.208SERRES F: 00357 22.028.210M: 6974197090 Center Cyprus Phone:

00357 77.77.6001

ITALYBel PasoVia Prima Retta Levante 237 CT T: 00393480695748

55 Alekos Constantine Street

OPEN LINE ___ 801.11. 99299(Calls only from line phone)

GREECE INTERNATIONAL OFFICES

SCIENTIFIC CONSULTANTSK. Kouzi, MD PhD Professor Histology - Embryology, AUTh, Mobile: +30 6944677746G. Koliakos, MD PhD Professor of Biochemistry, AUTh