septal activation impaired the retrieval of a previously stored hippocampal place cell...

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Page 1: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

Page 2: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

• Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age.

• When the environment was changed, medial septal activation impaired the encoding process in young, but facilitated the encoding of the new information in aged rats.

Page 3: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

Effect of aging on hippocampal place cells

Page 4: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

Medial septum and theta rhythm

Page 5: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

• Inactivation of the MS decreases hippocampal theta and spatial task performance.

• Intraseptal cholinergic drugs increase hippocampal theta power and can promote memory performance in scopolamine-treated or aged memory-impaired rats but not in young rats.

Page 6: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

So…

• The present study examined whether increased MS activation (by intraseptal carbachol, a cholinergic agonist) would promote remapping, indicating the encoding or establishment of a new representation of the environment within the hippocampus.

Page 7: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

Page 8: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

YOUNG

AGED

CONTROL CARBACHOL

Page 9: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

YOUNG

AGED

CONTROL CARBACHOL

Page 10: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

Page 11: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

Page 12: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

Page 13: Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

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