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• Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age.
• When the environment was changed, medial septal activation impaired the encoding process in young, but facilitated the encoding of the new information in aged rats.
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Effect of aging on hippocampal place cells
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Medial septum and theta rhythm
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• Inactivation of the MS decreases hippocampal theta and spatial task performance.
• Intraseptal cholinergic drugs increase hippocampal theta power and can promote memory performance in scopolamine-treated or aged memory-impaired rats but not in young rats.
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So…
• The present study examined whether increased MS activation (by intraseptal carbachol, a cholinergic agonist) would promote remapping, indicating the encoding or establishment of a new representation of the environment within the hippocampus.
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YOUNG
AGED
CONTROL CARBACHOL
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YOUNG
AGED
CONTROL CARBACHOL
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