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ABOUT THIS POSITIONCHANGING MEDICINE. CHANGING LIVES. 1

Search for Associate Director for Clinical Research and Holden Chair

UNIVERSITY OF IOWA HOLDEN COMPREHENSIVE CANCER CENTERSEARCH FOR HOLDEN FAMILY CHAIR AND DIRECTOR FOR CLINICAL RESEARCH2


ContentsAbout this search ........................................4

Holden Comprehensive

Cancer Center ..............................................9 History ...................................................................10 Today .....................................................................14 Holden Family Support ....................................16 Organization and Leadership ........................18 Research Programs .......................................... 22 Cores and Shared Resources ........................29

University of Iowa Health Care ............45

UI Carver College of Medicine .............59

UI Hospitals and Clinics .........................75

Health Sciences Campus ...................... 85

University of Iowa ....................................91

The Iowa City Community ...................97


About this PositionThe Holden Comprehensive Cancer Center (HCCC) at The

University of Iowa is seeking an outstanding clinician-

investigator to serve as the associate director for clinical

research and to direct the Roland W. Holden Family Program

in Experimental Therapeutics. The successful candidate will

also serve as the Holden Family Chair.

As the associate director for clinical research of an NCI-designated Comprehensive Cancer Center Center, the successful candidate will be expected to provide leadership and integrate all therapeutically related translational and clinical cancer research taking place within the institution, and also contribute to establishing external collaborations. The successful candidate will have an MD or MD/PhD degree, with a strong record of publication and funding, including external peer-reviewed funding, in clinical cancer research and experimental therapeutics. Experience in a multi-disciplinary setting, experience in program development in an academic medical center, commitment to diversity in the workplace, and excellent communication and leadership skills are required.

The ideal candidate will also have familiarity with both laboratory and clinical aspects of cancer experimental therapeutics and drug development, investigator-initiated and cooperative group clinical trials, knowledge of regulatory guidelines and procedures, and familiarity with NCI-designated Cancer Center operations.

The successful candidate will have their primary academic appointment in a clinical department at The University of Iowa Carver College of Medicine. A leadership role in the Division of Hematology, Oncology, and Blood and Marrow Transplantation in the Department of Internal Medicine is available based on the interest and qualification of the applicant.


The HCCC received NCI-designation in 1999 and comprehensive designation from the NCI in 2000. It has undergone successful competitive renewal of this designation twice since that time. The HCCC is organized in two different dimensions. The formal research programs of the HCCC are based on scientific discipline and include cancer immunology and immunotherapy, cancer signaling and experimental therapeutics, cancer genetics and gell growth, tumor imaging, free radical cancer biology, and cancer epidemiology.

In addition, a number of cancer type specific muliti-disciplinary oncology groups (MOGs) have been developed and are active in both clinical and research efforts. The HCCC has a robust Clinical Trials Support Core that includes 35 full-time staff who assist in protocol development, management, and the conduct of trials. The Clinical Trials Support Core also supports bedside to bench translational research including the prospective clinical registries of the HCCC. These are known as the Molecular Epidemiology Resources (MERs), work closely to the HCCC Tissue Procurement Core and biobanks, and have enrolled over 4,500 subjects in a variety of cancer types.


Role and ResponsibilitiesThe Holden Comprehensive Cancer Center associate director for clinical research will lead the clinical and translational research efforts of the cancer center. This includes providing administrative oversight of the clinical research infrastructure, clinical research collaborative efforts, clinical and translational research pilot grant programs, serving as a mentor to junior investigators and determining use of funds dedicated to clinical cancer research. The associate director will serve on the HCCC Leadership Committee and Research Executive Committee, and will chair the Clinical Research Leadership Committee.

The associate director for clinical research will supervise the assistant directors for clinical research. Together, they will oversee the Clinical Trials Support Core, Clinical Trials Development, Support and Monitoring Office, Protocol Review Committee and the Data and Safety Monitoring Committee as well as the 12 cancer-specific multidisciplinary oncology groups.


Endowed Positions and ProgramsThe Holden Endowment to support Experimental Therapeutics was established in 2000 to support research geared towards advancing knowledge of cancer and application of this knowledge to the discovery and development of new cancer therapeutics. This research is expected to include the design and synthesis of novel chemicals and testing of active agents in humans.

The endowment consists of two components.:

Holden Family ChairThis fund supports a chair in the University of Iowa Roy J. and Lucille A. Carver College of Medicine for the Director of the Roland W. Holden Family Program for Experimental Cancer Therapeutics.

Roland W. Holden Family Program for Experimental Cancer TherapeuticsThe Program itself is supported by the Roland W. Holden Family Endowed Fund.

Support for the clinical research infrastructure of the Holden Comprehensive Cancer Center comes from other sources so support from the Roland W. Holden Family Program for Experimental Cancer Therapeutics can be directed towards specific research projects in Experimental Cancer Therapeutics.

Dr. Raymond Hohl was the founding Director of the Program. Dr. Hohl’s efforts focused on the RAS pathway and novel approaches to targeting the isoprene intermediates in the cholesterol biosynthetic pathway. His efforts included extensive collaborations with synthetic chemists in the Department ofChemistry as well as a broad range of investigators across the Cancer Center. The next recipient of the Holden Chair will be expected to leverage the infrastructure and contributions developed by Dr. Hohl while also applying their own research expertise to goals of the Holden Program in ExperimentalTherapeutics.


Search Committee

KARL W. THOMAS, MD

ChairExecutive Vice Chair, Department of Internal MedicineProfessor of Internal [email protected]

MOHAMMED M. MILHEM, MBBS

Deputy Director for Clinical Cancer Care, Holden Comprehensive Cancer CenterAssociate Professor of Internal Medicine

[email protected]

KIMBERLY K. LESLIE , MD

Chair and Department Executive Officer, Department of Obstetrics and Gynecology

[email protected]

MICHAEL HENRY, PHD

Deputy Director for Research, Holden Comprehensive Cancer CenterAssociate Professor of Molecular Physiology and [email protected]

ALIASGER SALEM, PHD

Lyle and Sharon Bighley Professor of Pharmaceutical Sciences and Leader, Cell Signaling and Experimental Therapeutics Program, Holden Comprehensive Cancer [email protected]

PALOMA H. GIANGRANDE, PHD

Associate Professor of Internal Medicine

[email protected]

GARY ROSENTHAL , MD

Director, Iowa Institute for Clinical and Translational ScienceProfessor of Internal Medicine

[email protected]

YATIN VYAS, MD, PHD

Director, Division of Pediatric Hematology and OncologyProfessor of Pediatrics

[email protected]

JAMES C. WALKER, PHD

Associate Vice President for Research

[email protected]

BRIAN K. L INK, MD

Director, Clinical Trials Support Core, Holden Comprehensive Cancer CenterProfessor of Internal Medicine

[email protected]

About the Holden Comprehensive Cancer Center


Holden Comprehensive Cancer CenterEfforts to form a comprehensively organized program

in cancer began in the 1970s when former Dean John

W. Eckstein, MD charged the College of Medicine’s

Committee on Cancer with the responsibility of reviewing

and developing research, demonstration, and education

programs in cancer.

Richard L. DeGowin, MD began the effort by working with faculty members in the College’s of Medicine, Nursing, Dentistry, Pharmacy and Liberal Arts and Sciences and after much work, a plan was implemented for the creation of a more organized cancer program at the university. Following presentation to the Board of Regents, State of Iowa, in 1980 the new program was conferred special “center designation, ” and DeGowin became the Cancer Center’s first director.

Since 1980, the Cancer Center has experienced tremendous growth and achieved the highest level of recognition status given by the National Cancer Institute—comprehensive—in 2000. To reflect this achievement, and in recognition of a landmark, $25 million gift from four generations of the Holden family of Williamsburg, Iowa, the Cancer Center was renamed the Holden Comprehensive Cancer Center.

ABOUT THE HOLDEN COMPREHENSIVE CANCER CENTERCHANGING MEDICINE. CHANGING LIVES. 11


1981The Cancer Center received a three-year CancerCenter Support Grant from the National Cancer Institute. The grant was not renewed.

1980The University of Iowa cancer program is conferred special “center” status by the Iowa Board of Regents.

Richard L. DeGowin named director.

1986Cancer Information

Service opens.

1988University of Iowa, University of Iowa College of Medicine and University of Iowa Hospitals and Clinics leadership develop plans for expanded laboratory research initiatives and construction of new clinical care facilities.

1993With the support of a generous gift from the Pappajohn

family of Des Moines, the John and Mary Pappajohn Clinical Cancer Center opened, providing a multidisciplinary

approach to state-of-the-art patient care. This effort was coordinated by Richard D. Williams, MD.

1994The NCI provided funds for restructuring the Cancer Center through a P20 Cancer Center Planning Grant.

This effort was led by Richard G. Lynch, MD.

Robert B. Wallace, MD, was appointed as director of the Cancer Center.

1995University of Iowa President Mary Sue Coleman, PhD, College of Medicine Dean Robert Kelch, MD and R. Edward Howell, director and CEO of the UI Hospitals and Clinics—all recently appointed—reinforce institutional commitments to support and strengthen the Cancer Center.

1998George J. Weiner, MD, appointed

director of the Cancer Center.

Timeline


1999The Cancer Center submitted a Cancer Center Support Grant application to the National Cancer Institute.

2000The National Cancer Institute conducts a site visit of the Cancer Center in January.

The National Cancer Institute confers “NCI-designated Cancer Center” status in July.

The Cancer center receives a landmark, $25 million gift from four generations of the Holden family of Williamsburg, Iowa and is renamed Holden Cancer Center.

The Roland W. Holden Family Program for Experimental Therapeutics was established and Dr. Raymond Hohl, was named the Roland W. Holden Family Chair for Experimental Cancer Therapeutics.

Holden Cancer Center achieves the highest level of recognition—comprehensive status given by the National Cancer Institute and is renamed Holden Comprehensive Cancer Center.

2001Construction begins on the Holden Cancer Research Laboratories in the new Medical Education and Research Facility.

2002Completion of the new Roland and Ruby Holden Cancer Research Laboratories.

Iowa receives its first Specialized Program of Research Excellence (SPORE) Grant—the Iowa/Mayo Lymphoma SPORE.

2004Iowa Consortium for Comprehensive Cancer Control launched, providing coordinated cancer control for Iowans.

2005NCI-designation as a comprehensive cancer center renewed following competitive review.

2007New image guided center for radiation therapy opens.

Renewal of $11.9 million Specialized Program of Excellence (SPORE) grant for lymphoma research.

2008Center receives National Outstanding Achievement Award from the Commission on Cancer for providing superior care to patients and families.

Center Iowa teams up with several agencies to provide housing, transportation and medical assistance to cancer patients devastated by the floods and tornadoes in Iowa.

2011NCI-designation as a comprehensive cancer center following competitive review with a score of “outstanding.”

2014Dr, Raymond Hohl, associate director for clinical research and Holden Chair, moves to Penn State University as director of the Penn State Hershey Cancer Center.


The Center TodayHolden Comprehensive Cancer Center remains dedicated to bringing world-class research and cancer care to Iowa, the Midwest, and beyond.

The matrix center now spans the University of Iowa and includes approximately 180 formal Cancer Center members and many additional physicians, investigators and other staff from 36 related university departments and six colleges, as well as the University of Iowa Hospitals and Clinics and the University of Iowa Children’s Hospital.

Research at Holden Comprehensive Cancer Centeris organized into six research programs:

• Cancer Immunology and Immunotherapy

• Cancer Signaling and Experimental Therapeutics

• Free Radical and Cancer Biology

• Tumor Imaging

• Cancer Epidemiology

• Cancer Genomics and Cell Growth

Each of these programs is focused on a cancer-relevant scientific discipline, is translational, and includes members from several colleges and diverse backgrounds.

The Holden Comprehensive Cancer Center is also organized based on cancer type through the Multidisciplinary Oncology Groups (MOGs). The MOGs are responsible for coordinating multidisciplinary clinical care through tumor boards, multidisciplinary clinics, etc. They also serve as the focus for development of innovative clinical trials.

While research is conducted in laboratories throughout the University of Iowa campus, the Roland and Ruby Holden Cancer Research Laboratories allow the Center to integrate many researchers in close proximity to each other.

Outreach to the people of Iowa is an important component of the Center’s activities. Holden provides information through its Cancer Information Service to patients, their families, and health professionals. In addition, there are a number of cancer support groups that meet regularly in local communities. The Center also includes many patients in its active program of Phase I and Phase II clinical trials.


Holden Comprehensive Cancer Center Statistics

CLINICAL ACTIVITY

154,232Total visits to UI Health Care with

primary diagnosis of cancer

31,372Unique patients treated with primary diagnosis of cancer

48,288Total visits in the

cancer clinic

3,615Admissions for patients with a

primary diagnosis of cancer

3,800New cancer patients diagnosed

at UI Hospitals and Clinics

20,400Radiation oncology

treatments delivered

14,639Chemotherapy sessions

delivered

117Bone marrow transplants

(106 adult, 11 pediatric)

8,283Contacts to the Cancer

Information Service

CLINICAL FACILITIES AND SPACE

37Exam rooms in

the Cancer Clinic

3Consult rooms inthe Cancer Clinic

2 Treatment Rooms in

the Cancer Clinic

32 Chairs in the

chemotherapy suite

8Beds in the

chemotherapy suite

>146,000 Net square feet of

clinical oncology space

74 Inpatient beds on three units with a dedicated pharmacy

14Beds in the Adult Leukemia and

Bone Marrow Transplant Unit

31Bone bone marrow transplant and

hematology oncology beds

RESEARCH AND SPACE

$74.2 Million in total annual cancer-related

research funding

$44Million in current endowments in

support of the mission

221 Open clinical trials for

cancer patients

3,289 Patients enrolled in

clinical trials

189 Cancer Center members in 36 departments and six colleges

6Research Programs

in the Center

10Core Facilities supported by the

Cancer Center

4Core Facilities supported by the

Lymphoma SPORE grant

33,953Square feet of research space in Holden Research Laboratories


Holden Family SupportThrough years of visionary support for the Holden Comprehensive Cancer Center at the University of Iowa, the Holden family has helped establish the UI as a major center for cancer research, patient care, and education. The Holden Comprehensive Cancer Center was so named in 2000, when four generations of the Holden family made a landmark gift of $25 million to support what was then the University of Iowa Cancer Center. In the 13 years since the Holden gift, world-class research scientists, physicians, and other health care professionals have worked tirelessly to advance research that helps prevent, detect, and treat cancer for our patients. The Holden family gift was made in honor of the late Roland W. Holden, who died in 1995. Holden founded Holden Foundation Seeds Inc., a corn seed research and genetics company based in Williamsburg, Iowa, 30 miles west of Iowa City, in 1937. His family chose to celebrate his legacy by supporting research and treatment that may eventually cure the disease that took his life.

Contributors to the $25 million gift included Ruby Holden; Ronald, Arlene, and Kathy Holden; Susan and David McCurry; Karol Holden; Mary Ann and Curtis Blythe; and the Roland and Ruby Holden Foundation.

The gift, one of the largest received for UI Health Care initiatives, has supported a full range of critical programs within the Holden Comprehensive Cancer Center, including:

RESEARCH

Cutting-edge research, new cancer investigators, and studies that have translated laboratory discoveries into innovative patient treatment options.

The Clinical Trials Support Core, which include trials that come from our own labs, collaboration with other cancer centers, and partnerships with biotechnology and pharmaceutical companies. Treatments that would not otherwise be available in Iowa are available to our patients because of these trials.

PATIENT SERVICES AND CARE

The UI Palliative Care Service—a team of nurses, social workers, chaplains and physicians that assists terminally ill patients and their families. This interdisciplinary program provides emotional and spiritual support and help in planning for care outside the hospital, as well as pain control and symptom management.


The Holden family of Williamsburg, Iowa.

ABOUT THE HOLDEN COMPREHENSIVE CANCER CENTERCHANGING MEDICINE. CHANGING LIVES.


HCCC Executive BoardJean Robillard, MD

Vice President for Medical Affairs

DirectorGeorge Weiner, MD

Deputy Director for ResearchMichael Henry, PhD

Internal and External Advisory Boards

Executive Director of DevelopmentSarah Russett, UI Foundation

Associate Director for Clinical Research

Clinical Trials Data Management

ManagerMary Schall

Clinical Trials Regulatory Manager

Marian Andersen

Clinical Trials Translational

Research ManagerLaura Jacobus

Clinical Research SpecialistsM. Arnold (90%)R. ArthurM. FreesJ. Geick MillerK. ParrottJ. WegmannP. Zehr

Clinical Research AssociatesS. GillenJ. Schlabaugh

Clinical Research AssistantsJ. de la GarzaS. Teahen

Clinical and Data Management Research SpecialistA. Tricot

Data ManagersA. MarlofA. SchultzA. CapperA. Ulin

Medical Assistant IIJ. Larson

Regulatory AssociateT. Kriegel

Financial AnalystB. FranzwaJ. Gallagher

Cancer and Leukemia Group B CoordinatorC. Halvorsen

National Surgical Adjuvant Breast and Bowel Project CoordinatorC. Robertson

Clerk IIIL. Johnson (75%)

Translational Research AssistantsC. HamlinA. JanoskiT. KnutsonM. BrummS. Rosazza

Biospecimen Collection TechnicianJ. Cook-Granroth

Data ManagerS. Grimm (temp)

Assistant Director for Multidisciplinary Clinical Research

Mohammed Milhem, MBBS

Assistant Director for Clinical Research Services

Daniel Vaena, MDCarlie Etscheidt (Administrative Director)

Informatics SupportSystems Specialist

Inez Mattke

Organization

Protocol Writer and Safety OfficerM. Rosenquist

Protocol Management AssistantA. Childs

Multidisciplinary Oncology Groups

Carmen Tilman (Board Coordinator)

Multidisciplinary Oncology Group

Research Support Coordinator

Julianna Kennedy

Clinical Trials Support CoreBrian Link, MD

(Director)

Protocol Development and Monitoring Chair

Michael Goodheart, MD

DSM ChairDaniel Berg, MD

Protocol Review and Monitoring

Protocol Development and

Monitoring ManagerGary Rick


Leadership

George J. Weiner, MD Director, Holden Comprehensive Cancer Center

George Weiner MD, is an active translational cancer investigator who has been on the faculty at the University of Iowa since 1989. He is Director of the Holden Comprehensive Cancer Center (HCCC), Professor of Internal Medicine, C.E. Block Chair of Cancer Research, and a faculty member in the Interdisciplinary Program in Immunology at the University of Iowa.

Administratively, Dr. Weiner was appointed Director of the HCCC on December 1, 1998, and led the HCCC to recognition as an NCI-designated comprehensive cancer center in 2000. This designation was renewed in 2005 and 2011. Dr. Weiner was served in a number of leadership positions at the state and national level including the following.

• Chair, NCI subcommittee A also known as the Cancer Center Parent Committee (2007- 2009). He chaired site visits for the NCI at 8 cancer centers.

• Vice President / President Elect, Association of American Cancer Institutes (2013-present).

• President, Iowa Cancer Consortium (2003-present)

• Chair, Governmental Affairs Committee, American Society of Hematology (2008-2012)

• Co-Chair, Science Policy and Governmental Affairs Committee, American Association for Cancer Research (2012-present)

• Chair of External Advisory Boards for 3 NCI designated cancer centers.

• PI of the Iowa/Mayo Lymphoma SPORE (2002-present)

• Co-Chair, C-Change initiative on Comprehensive Cancer Control

• Member, CTAC - NCI Clinical and Translational Research Advisory Committee (2012-present)

Dr. Weiner’s research focuses on understanding the mechanisms of action of anti-cancer monoclonal antibodies, and on development of novel approaches to immunotherapy of lymphoma. He has been continually funded by the NCI since 1991. Dr. Weiner’s research extends from basic laboratory investigation to clinical trials. He is the holder of four patents with a number of others pending, and was the first to demonstrate Toll Like Receptor 9 agonists could be used successfully as immune adjuvants in tumor immunization. He also has made major contributions to our understanding of the mechanisms of action responsible for the anti-tumor activity of monoclonal antibodies.

19ABOUT THE HOLDEN COMPREHENSIVE CANCER CENTERCHANGING MEDICINE. CHANGING LIVES.


GAIL A . BISHOP, PHD

Associate Director for Basic Research

Dr. Gail Bishop, appointed associate director for basic research in 2004, advises the HCCC director on issues related to the basic science programs, including allocation of research space, and resources, and membership in the research programs. Bishop’s role is to coordinate and assure the quality of the basic science research programs of the Center, to provide advice on faculty recruitment in basic science areas, formulate program policy, and overseeing the use of basic science shared facilities in consultation with the associate director for research infrastructure. Bishop works with the HCCC director to encourage translation of basic advances to the clinic. As associate director for basic science, Dr. Bishop reviews all applications for HCCC membership. She is a member of both the HCCC Executive Committee and Associate Director’s Committee. The research programs that are primarily focused on basic cancer research (Cancer Genomics and Cell Growth, and Free Radical Cancer Biology) report formally to her. Dr. Bishop also provides advice related to the basic laboratory research taking place in the other four research programs.

ELIZABETH CHRISCHILLES, PHD

Associate Director for Population Science

Elizabeth Chrischilles, the Marvin A. and Rose Lee Pomerantz Chair in Public Health, and director, Health Effectiveness Research Center, was appointed as the HCCC associate director for population sciences in 2007.

In this role, Dr. Chrischilles is charged with enhancing the HCCC’s population science activities including epidemiology, prevention, community health, public policy and outcomes analysis. She provides leadership to the research programs considered primarily population science programs and provides advice and guidance to HCCC members relative to population science activities within the HCCC. She also has the responsibility of encouraging population science activities in the other research programs.

Dr. Chrischilles is a member of the HCCC Executive Committee and the Associate Directors Committee.

MICHAEL D. HENRY, PHD

Deputy Director for Research

Dr. Henry serves as deputy director for research. This important position is supported by institutional funds. He has focused his efforts on new initiatives and special projects including developing the overall Molecular Oncology Initiative. A major focus of this effort is improving tissue collection, annotation and distribution through the Tissue Procurement Core/Biospecimens Initiative including identification of a software package described above. He has also worked on integrating the molecular pathology group into the HCCC. This has included promoting meetings of the director of the Molecular Pathology Division, Dr. Aaron Bossler, with MOGs and medical oncologists to assess ongoing needs for new actionable molecular tests. In late 2013, the molecular pathology group received CLIA certification for sequencing capabilities of 50 cancer-related genes that are now being used for both clinical care and clinical research. Dr. Henry also chairs the monthly Research Executive Committee meeting which includes all of the Program Leaders and Co-Leaders.


DAVID M. LUBAROFF, PHD

Associate Director for Research Infrastructure

David Lubaroff, Ph.D., has served as associate director for research infrastructure since 1998. In his role, he is responsible for coordinating the shared research resources and working closely with the directors of these facilities to assure they are serving the needs of HCCC members. He serves on the faculty advisory committees of the majority of shared research resources supported by the HCCC. He also monitors usage of shared research resources and makes recommendations to the shared resource resources based on their performance. Dr. Lubaroff explores the need for and development of new shared research resources by periodically surveying HCCC membership to document shared facility activities and unmet needs. His responsibilities include developing, coordinating and maintaining research educational programs for members including seminars and conferences, and a program of visiting research scientists and lecturers. He coordinates the monthly HCCC Forum. Lubaroff works closely with HCCC administrative staff in oversight of shared research resource activities. Dr. Lubaroff is a member of the HCCC Executive Committee and Associate Directors Committee

MOHAMMED M. MILHEM, MD

Deputy Director for Clinical Cancer Services

Dr. Milhem has been a faculty member at the University of Iowa, and a member of the Holden Comprehensive Cancer Center since 2007.

He has a remarkable record of accomplishments related to clinical research team leadership in that period of time, and is an emerging leader in the field of clinical cancer research both institutionally and nationally.

Dr. Milhem is deputy director for clinical cancer services in hte Holden Comprehensive Cancer Center. In this role he leads the development of better clinical services to help the cancer center achieve its goals and to facilitate clinical cancer research and activities. He is leading many efforts to improve workflow for clinician researchers and improve processes.

CHRISTOPHER LAUBENTHAL , MBA

Associate Director for Administration

The associate director for administration, plans, directs, and coordinates, the administrative operations and activities of the HCCC including both research and clinical activities. Laubenthal facilitates interactions with the UI Hospitals and Clinics and the Carver College of Medicine to enhance clinical and basic research productivity. He serves as liaison with other departments, colleges, and outside organizations. He works closely with senior leadership to assure coordination and communication related to cancer oriented clinical service, research and education. He manages all fiscal activities, including coordination of annual budget process (operating and capital), analysis of income and expenditures, projections for annual budget requests, fiscal reports, equipment and supplies, maintenance, and assisting with and overseeing the grants management process. He is administratively responsible for the administration of the grant application process and the conduct of research activities in the HCCC including oversight of the shared core resources. This includes approximately $54.7 million in direct costs of which approximately 14.4 million is managed directly by the Cancer Center.


Cancer Immunology and Immunotherapy

ABOUT THE PROGRAM

The Cancer Immunology and Immunotherapy Program consists of faculty investigators who are linked by common research interests in the functioning of the immune system, and how that system can be manipulated to help prevent or treat cancer and complications of cancer. The investigators in this program are working on problems that extend from fundamental molecular questions to those involving how recent advances in basic immunology can be translated into clinical utility for the treatment of cancer.

Although many of investigators in the Cancer Immunology and Immunotherapy Program are pursuing related questions, the individual research programs are diverse, allowing researchers in this program to attack basic biologic issues, and develop new clinical therapies, from many angles. Model systems being studied range from an evaluation of signaling properties of T and B cells, to increasing the efficacy of vaccines and immunotherapy in living animals, through the conduct of novel clinical trials related to cancer immunotherapy. Clinical applications, as a direct result of more basic investigations, have arisen from within the group and it is expected that this will continue.

Because of the diversity of research interests reflected within the membership of the Cancer Immunology and Immunotherapy Program, a wide range of technologies and approaches are available to investigators. Each of our investigators benefits from interactions with others in the program, as well as members of additional Cancer Center programs, resulting in a synergism yielding new insights, perspectives, and collaborative efforts.

LEADERSHIP

ZUHAIR K. BALLAS, MDProfessor of Internal Medicine

GAIL A. BISHOP, PHDProfessor of Microbiology and Internal Medicine

Research Programs


Cancer Signaling and Experimental Therapeutics Program

ABOUT THE PROGRAM

The overall organizational goal of the Cancer Signaling and Experimental Therapeutics Program is to facilitate the application of recent advances in our understanding of cell signaling, cell cycle control, and apoptosis, to the development of new pharmacologic approaches to cancer prevention and therapy.

Investigators in this program are working on problems that extend from fundamental molecular questions involving signaling pathways to those involving the design of novel compounds based on our growing knowledge of molecular aspects of cell biology. Such laboratory scientists collaborate with other members of the Program who are clinical investigators with a broad range of backgrounds and expertise in performing innovative clinical cancer trials.

The program includes basic and clinical investigators from multiple departments at the University of Iowa, and has members who have primary appointments in the Colleges of Medicine, Pharmacy, and Liberal Arts.

LEADERSHIP

ALIASGER K. SALEM, PHDAssociate Professor of Pharmaceutics

YATIN M. VYAS, MDProfessor of Pediatrics

Kimberly Leslie, MD at work in her laboratory.


Tumor Imaging Program

ABOUT THE PROGRAM

The goal of the Imaging Program is to foster interdisciplinary research that integrates modern medical imaging techniques into basic, translational, and clinical cancer research studies. The methodologies will include computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, positron emission tomography (PET), gamma scintigraphy, optical imaging, and autoradiography. Metabolic imaging extends the capability of imaging well beyond anatomy. It includes imaging blood flow, vascular permeability, metabolic rates (glucose, oxygen, DNA synthesis, protein synthesis, membrane synthesis), receptor distribution and density (estrogen, testosterone, somatostatin), apoptosis, angiogenesis, cell trafficking, and reporter gene activation. Members of the imaging program are working in all these areas. The importance of having an Imaging Program is that it brings these investigators together to collaborate, and share ideas, imaging strategies, and data analysis methods.

The Imaging Program has the following specific areas of focus:

• Metabolic assessment of response to therapy

• Iodine symporter as a reporter gene and as a novel therapy

• Cell trafficking

• Development of new radiopharmaceuticals

• Development of novel analysis methodologies

LEADERSHIP

MICHAEL GRAHAM, MD, PHDProfessor of Radiology

JOHN BUATTI, MDProfessor and Chair, Radiation Oncology

Eric Hoffman, MD works with students and staff in the Magnetic Resonance Research Facility.


Free Radical and Cancer Biology Program

ABOUT THE PROGRAM

For many years it has been recognized that many agents used to treat cancer (i.e., radiation and chemotherapy agents) cause oxidative stress that contributes to the mechanism by which they kill cancer cells as well as damage normal tissues. Recently, it is becoming increasingly clear that metabolic oxidation/reduction (redox) reactions are also altered in cancer vs. normal cells. The current consensus is that cancer cells may exist in a chronic state of metabolic oxidative stress that may represent a significant underlying mechanism contributing to malignancy. A unifying goal of the investigators in the Free Radical Cancer Biology Program is to utilize a comprehensive understanding of redox biology to develop novel biochemical rationales for improving cancer therapy taking advantage fundamental differences in oxidative metabolism between cancer vs. normal cells.

The researchers in the Free Radical Cancer Biology Program (FRCBP) focus on studying the biological consequences of inherent differences in redox metabolism between cancer vs. normal cells to determine the role that redox reactions play in cancer phenotypic changes relevant to cell growth, differentiation, signal transduction, metastasis, functional molecular imaging, and cancer therapy. A unifying goal of the program is to utilize a comprehensive basic science understanding of cancer cell redox biology to develop novel biochemical rationales for improving cancer therapy. Three overlapping themes exist within the program.

LEADERSHIP

DOUGLAS R. SPITZ, PHDProfessor of Radiation Oncology

FREDERICK E. DOMANN, JR., PHDProfessor of Radiation Oncology

Theme 1Understanding the role of redox biochemistry in regulation of genetic and epigenetic gene expression pathways relevant to cancer biology. Within this theme are focus groups exploring redox and gene expression globally, as well as gene expression of key redox molecules such as glutathione, thioredoxin, SOD, and AP2.

Theme 2Understanding the role of redox regulation in cell biology. Within this theme are focus groups exploring the effects of intracellular redox environmental changes on the cell cycle, and on invasion and metastasis.

Theme 3Exploring the role of oxidative stress in cancer therapy outcomes. Within this theme are focus groups exploring the role of manipulating oxidative stress to improve cancer therapy as well as using imaging of oxidative metabolism as an approach to monitor and guide therapy.


Cancer Epidemiology Program

ABOUT THE PROGRAM

The overall goal of the Cancer Epidemiology Program is to save lives by increasing our understanding of what causes cancer, promoting cancer prevention behaviors and early detection and treatment, and developing improved diagnostic tests and treatments. When cancer cannot be prevented, we are also interested in research that will extend the quantity and quality of

life for the cancer survivor.

A major strength of the Cancer Epidemiology Program is its extension beyond the walls of the medical center, as its primary research population is residents across the state of Iowa. This is based on the role played by the University of Iowa in public health across Iowa, including cancer epidemiology. Members of the Cancer Epidemiology Program

are responsible for the State Health Registry of Iowa (SHRI), Iowa’s statewide cancer surveillance program that is part of the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (NCI). This resource allows researchers in the Cancer Epidemiology Program to perform outstanding population-based cancer research. Information gained from these studies can then be applied to other states and other populations.

The Cancer Epidemiology Program has three focus areas.

• Cancer Etiology

• Cancer Health Services and Outcomes

• Cancer Prevention and Control

LEADERSHIP

CHARLES F. LYNCH, MD, PHDProfessor of Epidemiology and Pathology

Barcey Levy, MD, PhD


Cancer Genomics and Cell Growth Program

ABOUT THE PROGRAM

Research in the Cancer Genomics and Cell Growth Program focuses on genetic and molecular events controlling normal versus malignant cell proliferation, differentiation and survival. The overall goal of the program is to define biologically significant genetic and molecular alterations in tumor cells so that information can be used to more effectively detect and treat human cancers. There are two major overlapping themes within the umbrella of the Progam’s research.

Theme 1 Genomic organization and cancer gene expression/analysis

Theme 2 Cell growth, differentiation, survival and transformation.

Major accomplishments of the Cancer Genomics and Cell Growth Program over the past funding period are best reflected by its identification and characterization of novel cancer genes and/or biomarkers, development of novel animal tumor models to discover and assess cancer gene function in vivo, and increasing collaboration as demonstrated by coalescence of program members into effective working groups. Key examples of intraprogrammatic research collaborations include a) studies revealing the role of chromatin binding proteins (such as RPA, DNA polymerases, HP1, transcription factors) in gene expression and how that impacts the cancer phenotype, b) studies defining basic mechanisms of viral infection and replication, and how that leads to cell transformation, and c) the discovery and subsequent functional analysis of novel genetic pathways of carcinogenesis. There are numerous past and present productive collaborations both between members of the Program, and with members of other Cancer Center programs. There are currently 16 NIH and NCI funded projects involving multiple Program members and/or HCCC members from other programs serving as co-Investigators. The program consists of 36 members from 12 departments (8 basic science and 4 clinical departments) and 5 Colleges. Peer-reviewed, research funding for this program totals $8,449,398 with $2,583,657 coming from the NCI.

Members of the Program have 300 cancer-related publications with nearly 30% collaborative publications (17% intra-programmatic, 12% inter-programmatic) during the last grant period.

LEADERSHIP

DAWN E. QUELLE, PHDAssociate Professor of Pharmacology

SIEGFRIED JANZ, MD, DSCProfessor of Pathology


Core Facilities and Shared ResourcesThe Holden Comprehensive Cancer Center provides Center members with access to the services and resources of our core facilities. The facilities provide quality products and services that enhance the research efforts of Cancer Center investigators to foster basic and translational research. Members of the Cancer Center with peer-reviewed, funded projects are the primary beneficiaries of these core resources.

The core facilities within the Holden Comprehensive Cancer Center are funded by a combination of funding from the Cancer Center Support Grant, Institutional support, other University of Iowa sources and charge-back for services. David Lubaroff, PhD, associate director for research infrastructure oversees these cores.

Cancer Center Support Grant

• Clinical Trials Support Core

• Bioinformatics Core

• Biostatistics Core

• Central Microscopy Research Facility

• DNA Core

• Flow Cytometry Core

• Gene Transfer Vector Core

• High Throughput Screening Core

• Population Research Core

• Radiation and Free Radical Research Core

• Small Animal Imaging

• Tissue Procurement Core

Lymphoma SPORE Grant

• Biospecimens

• Biostatistics and Bioinformatics

• Clinical Research

Other Resources

• Molecular Pathology Resource

• Proteomics Resource

• Drug Discovery Resources

Clinical Trials Support Core

• Clinical Trials Data

• Clinical Trials Regulatory

• Clinical Trials Translational

• Protocol Development and Monitoring


Clinical Trials Support Core

SERVICES

• Routing of protocols through the University of Iowa Institutional Review Board or Western Institutional Review Board and the appropriate regulatory committees

• Providing expertise in coordination of clinical trial activities (recruitment of patients, determining eligibility, obtaining consent, scheduling procedures, coordinating patient care needs, managing data collection)

• Serving as liaison to pharmaceutical companies, governmental regulatory agencies and other outside vendors

• Budget writing and billing

• Assisting investigators with annual reviews, protocol modifications and reporting of adverse events

• Providing assistance with collection and processing blood and tissue samples for translational research

• Listing of all current clinical trials in the clinical trials booklet

The Holden Comprehensive Cancer Center is also an active participant of seven National Cooperative Groups and investigators within the Center enroll over 550 patients on clinical research studies each year. The National Cooperative Group Trials that are involved within the Holden Comprehensive Cancer Center include:

• Cancer and Acute Leukemia Group B (ALLIANCE)

• National Surgical Adjuvant Breast Project (NSABP)

• Eastern Cooperative Oncology Group (ECOG)

• Collaborative Ocular Melanoma Study (COMS)

• Children’s Oncology Group (COG)

• Gynecological Oncology Group (GOG)

• Radiation Therapy Oncology Group (RTOG)

The Clinical Trials Support Core is currently staffed by approximately 32 staff members.

LEADERSHIP

BRIAN K. LINK, MDDirector

PURPOSE

The Clinical Trials Support Core (CTSC) provides administrative services and data management to all members of the Holden Comprehensive Cancer Center who conduct clinical studies.The CTSC is a shared resources and is designed to facilitate the conduct of high-quality clinical and translational cancer research and is composed of dedicated staff with expertise in protocol management and study coordination.


Bioinformatics Core

SERVICES

Assistance is available on all types of projects, ranging from clinical trials to basic science experiments. Early consultation during the design of a study may be especially beneficial.

• Consultation on study design, selection of technology platforms and formulation of hypotheses

• Specification of appropriate software tools and methods for data analysis

• Database creation (DNA sequence, RNA expression, proteomics, etc.)

• Protocol development

• Information technology consultation

• Data and experiment analysis

• Assistance in preparation of manuscripts

• Education and training

LEADERSHIP

THOMAS L. CASAVANT, PHDDirector

PURPOSE

To provide bioinformatics support for Cancer Center investigators in the design, data collection/archiving and analysis of high-throughput genomics assays in cancer research projects.

Biostatistics Core

SERVICES

Assistance is available on all types of projects, ranging from clinical trials to basic science experiments. Early consultation during the design of a study may be especially beneficial.

• Consultation on study design, selection of outcome variables and formulation of hypotheses

• Specification of appropriate methods of data analysis

• Protocol development

• Generation of randomization schedules

• Data analysis

• Assistance in preparation of manuscripts

• Education and training.

LEADERSHIP

BRIAN J. SMITH, PHDDirector

PURPOSE

To provide statistical support for Cancer Center investigators in the design, analysis, and reporting of cancer research projects.


Central Microscopy Research Facility

SERVICES

• Scanning electron microscopy

• Transmission electron microscopy

• Light microscopy

• Laser capture microdissection

• Confocal microscopy

• Multi-photon microscopy

• Cryo-techniques

• Elemental analysis

• Atomic force microscopy

• Bioluminescence microscopy

The facility also provides all solutions, supplies and training necessary for investigators involving microtomy including:

• Specialized staining and embedding techniques

• Negative staining

• Metal coating

• Autoradiography

• Cryo-fixation

• Cryomicrotomy

• Enzyme-cytochemistry

• Immunocytochemistry

• Morphometry

• Stereology

LEADERSHIP

RANDY A. NESSLER, BGS, MBA Director

PURPOSE

The Central Microscopy Research Facility provides instrumentation and technical assistance to research programs involving the use of scanning and transmission electron microscopy, light and confocal microscopy, scanning probe microscopy, freeze fracture and x-ray microanalysis.

Scanning electron microscopy.


DNA Core

SERVICES

• DNA Microarrays (Affymetrix GeneChip system and Custom DNA microarrays using slide format)

• Real-time PCR

• DNA Sequencing (Sanger dideoxy sequencing using capillary-based instruments and genomic sequencing using the Roches 454 and ABI SOLID instruments

• Synthetic Oligonucleotide

• Molecular biology computing including custom nucleic acid analysis, microarray analysis and genomic sequence assembly/analysis.

• Bioanalyzer to assess nucleic acid quality and quantity

LEADERSHIP

KEVIN KNUDTSON, PHDDirector

PURPOSE

The purpose of the DNA Facility is to provide a centralized resource for access to state-of-the-art equipment used in DNA sequence and transcript analysis. The DNA Facility strives to provide high quality services with rapid turnaround and support their services with well trained personnel that are able to consult with users on how they may best utilize their services. The DNA Facility continues to evaluate and update their services so they remain cutting-edge, and provide new services as necessary to continue to meet the needs of Center investigators.

Kevin Knudtson, PhD gives a tour of the core during a STEM education program.


Flow Cytometry Core

SERVICES

In addition to identification and isolation of various cell populations using antibodies, flow cytometry can analyze:

• Cell proliferation response to drugs or treatments, such as those used in chemotherapy

• Cell physiological properties, such as calcium flux and pH

• DNA content and integrity

• Transfection markers such as GFP and mCherry

Offline data analysis using FlowJoTM, CellquestTM, and ModFITTM can be done through the facility’s system of networked computers. Investigators equipped with IBM or Mac-compatible PCs can perform analysis at their laboratories or offices by accessing data through the Facility’s dedicated 1.5 terabyte file server.

The facility provides scientific and technical personnel who are available for consultation in designing experimental protocols. Cell preparation protocols and publication quality output are available upon request.

LEADERSHIP

ZUHAIR K. BALLAS, MDDirector

PURPOSE

The Flow Cytometry Core is located in the Eckstein Medical Research Building (EMRB). The facility has one magnetic-based and six laser-based instruments whose major purpose is the identification and isolation of various cell populations. The laser-based instruments accomplish this by the use of antibodies to which various colors or dyes have been attached and are directed at molecules known to exist on the cell surface. By using several colors attached to different antibodies, one can identify and purify cells that express any given configuration of various molecules.

A student is trained on instrumentation in the core.


Gene Transfer Vector Core

SERVICES

The University of Iowa Carver College of Medicine GTVC brings together investigators interested in developing and using, viral and non-viral vectors for gene transfer with specialists in the area of vector construction by:

• Consultation with the principal investigator to plan and develop transfer vectors to fit individual projects requirements

• Assist investigators with troubleshooting existing projects

• Design and development of novel vectors

• Develop novel methods of virus production such as the RapAdTM System for adenovirus production

• Generation of RNAi expression vectors

• Purify, concentrate, and perform quality control on preparations of recombinant adenovirus, adeno- associated virus (AAV), moloney murine retrovirus, lentivirus, baculovirus, and vaccinia virus

• Maintain and distribute standard cell lines and stocks of recombinant reporter viruses

LEADERSHIP

BEVERLY L. DAVIDSON, PHDDirector

PURPOSE

The Gene Vector Core assists researchers interested in developing and using viral vector construction. The core utilizes molecular biology techniques to engineer and produce viral and non-viral vectors in quantities necessary for gene transfer in research experiments or preclinical studies. Core staff works closely with investigators to plan and develop gene transfer vectors to fit individual project requirements.


High Throughput Screening Core

SERVICES

A robotic platform is available with 8-independent channels and a 384 channel pipetting head. A liquid handling robot is also equipped with on-board incubators (4 plates) and two positions for incubation/chilling of stock solutions.

An integrated Perkin Elmer Envision Multimode high speed plate readed for use with detection is equipped with filters and monochromators. The plate reader, controlled through the integrated software, supports fluorescence, time-resolved flouorescence, fluorescence polarization, time-resolved FRET, absorbance and specialized screening technologies including AlphaScreen, DELFIA and LANCE. The Envision is also equipped with two photomultipliers and a dedicated uHTS laster for high speed AlphaScreen.

The laboratory is also equipped with a five-color Roche Lightcycler 480 II system, allowing for secondary confirmation of hits binding to a purified target using differential scanning fluorimtetry.

Two small molecular libraries are currently available. The Spectrum Library consists of 2,320 structurally diverse compounds including marketed and experimental drugs and natural products. A larger collection houses 50,000 small molecules representing a wide swath of chemical space, optimized to be “drug-like.”

Management of compound library plates and screening data is done through M-Screen, a web-accessed academic database for analysis and curation.

LEADERSHIP

MENG WU, PHDDirector

PURPOSE

Initiated by the Vice President for Research and the Holden Comprehensive Cancer Center through collaboration with multiple departments, and housed in the College of Pharmacy, the High Throughput Screening, Target Validation and Biomarker Identification Resource is aimed at pharmacologic characterization of new molecular entities in enzyme, receptor and cell-based systems, including potency, intrinsic activity, selectivity, specificity, and off-target effects. This activity also includes the identification and validation/qualification of biomarkers for target activation/inhibition, proof-of-concept, efficacy and safety. An example is the use of high throughput screening for the discovery of novel pre-therapeutic lead molecules directed at neurological applications. Strong leadership and multiple pilot grants have led to a large number of collaboration exploratory projects in the very short time that the center has been functional.


Population Research Core

SERVICES

• Collaborating with investigators to develop population- based study protocols

• Providing expertise in coordination of field research activities, including subject recruitment and data collection management

• Providing expertise in coordination of database research activities, including linkage studies

• Providing expertise in coordination of GIS research activities

• Providing assistance with collection and processing of paraffin-embedded tissue samples from the Iowa Tissue Repository, Iowa Virtual Tissue Repository, or Iowa Residual Tissue Repository

• Assisting with TeleForm to design data collection forms and databases

• Facilitating use of data resources for population science

• Maintaining a database of all current population science studies and investigators

LEADERSHIP

BRAD MCDOWELLL, PHDCo-Director

PURPOSE

The purpose of the Population Research Core is to foster new research projects and collaborations of clinical, basic, and population scientists to further individual and population health. The core aims to foster projects of the highest quality genetic, epidemiologic, behavioral, applied, and surveillance cancer research.

The core is composed of staff who are based in institutional centers of expertise, with intimate knowledge of the resources of these centers and how to harness them. Staff include computer programmers, database analysts, and research scientists.

The following are select cancer research projects currently ongoing in the High Throughput Screening Core:

Title/Target Principal InvestigatorSynergistic killing of cancer cells with metformin Knudson (Pathology)Molecules that sensitize melanomas to chemotherapy DeMali (Biochemistry)Identification of EMT-selective cytotoxic compounds Henry (Physiology)Multiple myeloma inhibitors of RAD52 Bishop (Microbiology)Small molecule inhibitors of RAD52 Spies (Biochemistry)NEK2 inhibitors Zhan (Internal Medicine)Grb2-SOS1 modulators Houtman (Microbiology)Replication protein A Wold (Biochemistry)Telomere-dependent and independent mechanisms of senescence Klingelhutz (Microbiology)Integrins as major receptors for extracellular matrix proteins Stipp (Biology)Regulation of DNA methyltransferase 1 Brenner (Biochemistry)Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains Fuentes (Biochemistry)RGS proteins and their inhibitors Roman (Pharmacy)Mitochondrial targeted small molecules for radionucleotide imaging and Schultz (Radiology)cancer therapy


In111 SPECT Imaging.

PET/CT Imaging.

Radiation and Free Radical Research Core

SERVICES

The core provides or advises users on how to perform and analyze experiments, aiding in vector development, enzyme activity assays, cell cycle and thiol analysis, western, northern, and Southern analysis.

Available enzyme assays include: copper-and zinc-containing superoxide dismutase (CuZnSOD),

manganese-containing superoxide dismutase (MnSOD), catalase (CAT), glutathione transferases (GSTs), gamma-glutamyl transpeptidase (GGT), gamma-glutamylcysteine synthetase (GCS), and glutathione peroxidases (GPx). Assays for prooxidant production (superoxide, hydrogen peroxide, lipid peroxidation products, etc.) are available.

Antibodies, cDNA probes, and adenoviral vectors coding for

primary antioxidant enzymes as well as stably and transiently transfected cells are also provided. The core aids in transfecting cDNAs into cell lines of interest to investigators, and continues to develop and maintain novel reagents for studies in free radical biology including: antibodies, cDNAs, antisense reagents, and expression vectors for antioxidant proteins including thioredoxin, glutaredoxin, thioredoxin reductases, and thioredoxin peroxidases.

The core provides comprehensive irradiation services (both x-ray and 137Cs) and expertise in redox regulation of the cell cycle and phosphorimaging.

LEADERSHIP

DOUGLAS R. SPITZ, PHDDirector

PURPOSE

To provide free radical and radiation biology expertise, reagents, technologies, and analysis for individual investigators in the HCCC doing basic, pre-clinical, and clinical research.

Douglas Spitz, PhD at work with staff.


Small Animal Imaging Core

SERVICES

The core staff will assist investigators with defining which one or more of the imaging modalities are appropriate for their project. The core will work with the investigators to develop a time table for experiments, determine suitable numbers of animals to demonstrate feasibility and/or significance and assist the entire research team with imaging sequences. The core will utilize awake imaging whenever possible to limit animal complications and mortality. The staff will also assist with collaborations between HCCC investigators and other experts across the entire UI campus in order to facilitate synthesis of new radiopharmaceuticals, contrast agents, specialized techniques, etc. that may be necessary for specific experiments.

• Consultation on development of imaging protocol(s)

• Assistance with ACURF submission(s)

• Animal preparation and monitoring prior to and during imaging

• Single or multiple modality imaging,

• Image reconstruction, data reduction/analysis and result interpretation

The core’s instrumentation consists of several imaging modalities which have been specifically purchased or modified for scanning small rodents.

• PET

• SPECT

• Gamma camera

• Autoradiography

• CT

• MRI

• US

• Optical imaging

LEADERSHIP

JOHN SUNDERLAND, PHD, MBADirector

PURPOSE

To provide a comprehensive service for non-invasive anatomical and physiological imaging of mice and rats. The ultimate product of the core involves spatial imaging (high resolution pictures) and temporal imaging (longitudinal studies) related to cancer biology, drug development, and assessment of therapeutic intervention.

In111 SPECT Imaging.

PET/CT Imaging.


SERVICES

Investigators who are interested in obtaining human tissue samples from the Facility should begin by contacting the TPC office to discuss the project and determine if the core can potentially meet the project tissue requirements.

If the discussion concludes that the request is ready to advance to the stage of making a formal application, the investigator will be directed to the core web site to complete an online application.

Completed applications will be forwarded for review to the Tissue Utilization Committee. The Committee will recommend approval or disapproval. Priority will be given to those studies that are supported by peer reviewed funding or foster collaborative work. A signed IRB approved usage agreement is required.

The Tissue Procurement Core has worked with the HCCC to develop a federated system of disease-specific tissue biorepositories. In this system, all repositories use the same informatics system supported by the HCCC and institution (we have recently licensed and are currently transitioning to Biomatrix). This allows investigators across the institution to know what samples are available for research. Each of the federated biorepositories retains oversight on use of samples from their own biorepository with the expectation they will provide qualified investigators access to samples. Once a year, each repository submits an application to the Tissue Utilization Committee describing requests for tissue that have been approved or denied and other information to assure equitable access to samples. This system has been working well and combines the incentive that comes from local control with the efficiency, quality assurance and transparency that comes from a more centralized approach.

LEADERSHIP

C. MICHAEL KNUDSON, MD, PHDDirector

Tissue Procurement Core

PURPOSE

The goal of the Tissue Procurement Core Facility is to properly obtain and make human tissue available for current and future cancer research studies. The Core provides research infrastructure in the form of Institutional Review Board approved consenting and distribution procedures, pathology directed collecting procedures, and a well-characterized repository of frozen or routinely processed, neoplastic and normal tissues suitable for molecular genetic, biochemical and pathological studies. Prospective collections that meet specific research requirements not ammenable to fulfillment from the repository are also possible.

Cryostorage in the core.


Molecular Pathology Resource

SERVICES

The CLIA-approved molecular pathology laboratory has a diverse array of molecular oncology, genetics and infectious disease tests that support the missions of the Holden Comprehensive Cancer Center and the UIHC. Testing is primarily focused on DNA evaluation through the use of laboratory developed assays some of which are kit based. The laboratory also has the ability to perform RNA-based testing. The laboratory has a demonstrated record of new test development (17 new tests in the last 3 years) with significant cost savings for the institution. The laboratory has recently implemented massively parallel next generation sequencing using the Ion Torrent Personal Genomics Machine (PGM) platform with the detection of commonly mutated or hotspot gene regions in cancer from 50 genes representing more than 2800 mutations.

LEADERSHIP

AARON BOSSLER, MD, PHDDirector

PURPOSE

The Molecular Pathology Core develops and provides tests that University of Iowa Hospitals and Clinics and regional Iowa physicians need most, and assists in directing reference laboratory testing for those tests that are not provided on the current Molecular Pathology testing menu.

The lab also develops new tests in the areas of genetics and infectious disease, such as ISPD and DYSF gene sequencing for patients with suspeected inherited neuromuscular disease, and a qualitative PCR test for hepatitis E virus (HEV).


Proteomics Resource

SERVICES

Services currently available in the facility include:

• Protein identification and mapping

• Protein expression profiling

• Accurate weight determination for intact macromolecules and conjugates

• Development of quantitative MRM assays

• Characterization of PTM status

• Rapid biotyping to determine bacterial strains

• MALDI and nano LC-MS/MS analyses of digests performed either in-gel or in-solution

• MASCOT, SEQUEST and SpectrumMill data analyses with final reporting in Scaffold or Excel format

LEADERSHIP

MARSHALL POPE, PHDDirector

PURPOSE

The Proteomics Facility makes available several instruments for micro-sequencing, structural analysis, and quantitative studies of proteins. Facility staff are available for consultation and to assist in the characterization of both targeted protein complexes and trace components in lysates and sera.

Yalan Li works with facility instrumentation.


Drug Discovery ResourcesThe Holden Comprehensive Cancer Center has a long-standing, collaborative, productive relationship with the College of Pharmacy at the University of Iowa. For example, Dr. Aliasger Salem from the College of Pharmacy is the leader of the Cancer Signaling and Experimental Therapeutics Program. The following are capabilities involving the College of Pharmacy that enhance the Experimental Therapeutics efforts of the Holden Comprehensive Cancer Center.

Synthetic Medicinal Chemistry ResourceThe Lead Design and Discovery Resource is involved in the design synthesis, and chemical and biological characterization of new chemical entities targeted at finding specific and selectively acting novel drug mnolecules. In addition, small molecule drug discovery is aided through structure-based drug design and computer-aided drug discovery, with a particularly strong emphasis on enzyme drug targets, ensuring a state-of-the-art drug discovery process.

Drug Metabolism, Toxicity and Delivery Resource Faculty are also focused on drug metabolism and carcinogenesis, chemical toxicology, and neurochemistry. Other faculty are also engaged in research in the areas of gene delivery system development.

Preformulation and Formulation Development Resource

The Preformulation and Formulation Development Resource, known as The University of Iowa Pharmaceuticals Development Consortium, was formed between the University of Iowa College of Pharmacy pharmaceutics faculty and The University of Iowa Pharmaceuticals. The unit’s focus is the preformulation and formulation development, especially for compounds that present scientific challenges (solubility, stability, polymorphism, etc.). This resource adds extensive expertise in preformulation studies, material characterization, stability, and formulation development and packaging development. Other activities in the area of physical pharmacy involves novel drug delivery systems, cancer vaccines, and tissue engineering.


Pharmaceutical Manufacturing Resource

The University of Iowa Pharmaceuticals is the largest, and most experienced university-affiliated FDA-registered pharmaceutical manufacturing facility in the United States. This current Good Manufacturing Practices manufacturing facility is under the direction of Professor Mickey Wells. UI Pharmaceuticals has been developing formulations, manufacturing products, and conducting analytical testing in compliance with current Good Manufacturing Practices for nearly 40 years. The facility has capabilities for sterile product, solid dosage form and general manufacturing and a 30 plus year track record of producing clinical supplies for early trials for industry as well as university investigators.

Clinical Development Resource

This resource includes activities and services necessary to design, execute, analyze, and report a clinical research protocol. This resource conducts state-of-the-art laboratory analysis (LC/MS) of pharmacotherapeutic compounds in a variety of biological matrices. Activities also includes ADME (absorbtion, distribution, metabolism, and excretion) studies; and pharmacokinetic, pharmacodynamic and pharmacogenomic studies. Analysis of study data using advanced PK and PD modeling. Activities also include the conduct of phase I and II clinical trial design and protocol review and assist in the preparation clinical pharmacology sections of FDA applications.

Facility Director, Meng Wu, PhD at work in the High Throughput Resource.

University of Iowa Health Care


University of IowaHealth Care

University of Iowa Health Care is Iowa’s only comprehensive

academic medical center. Through its members, UI

Hospitals and Clinics, UI Roy J. and Lucille A. Carver College

of Medicine, and UI Physicians, UI Health Care provides

tertiary and quaternary level patient care, educates future

medical and allied health professionals, and conducts

significant leading edge research.

A Comprehensive Academic Medical CenterComprehensive, multidisciplinary care is a hallmark of an academic medical center. Care provided by UI Health Care ranges from routine primary care to sophisticated care of patients with complex and/or rare conditions.

The full spectrum of specialty and subspecialty care draws patients from Iowa, the region, and around the world.

The faculty and staff of UI Health Care conduct biomedical research that has led to some of the most important discoveries in treatment for cancer, heart attack, stroke, eye diseases, hearing loss, genetic diseases, birth defects, and many other conditions.

And, through its educational mission, UI Health Care trains the next generation of global leaders in patient care, medical research, and education.

UI Health Care is guided by a common strategic plan to maximize its ability to support and improve the health and well-being of the people of Iowa and influence the delivery of health care throughout the world. The common themes throughout the strategic plan are those of achievement, inclusion, collaboration, and accountability – all directed toward excellence in our mission of patient care, education, and research.

UNIVERSITY OF IOWA HEALTH CARECHANGING MEDICINE. CHANGING LIVES. 47

Mission

Simply stated, our mission is:

Changing Medicine.

Changing Lives.®

University of Iowa Health Care is changing medicine through:

• Pioneering discovery

• Innovative interprofessional education

• Delivery of superb clinical care

• An extraordinary patient experience in a multidisciplinary, collaborative, team- based environment

University of Iowa Health Care is changing lives by:

• Preventing and curing disease

• Improving health and well–being

• Assuring access to care for people in Iowa and throughout the world

Vision

World Class PeopleBuilding on our greatest strength

World Class MedicineCreating a new standard of excellence in integrated patient care, research, and education

For Iowa and the WorldMaking a difference in quality of life and health for generations

University of Iowa Hospitals and Clinics


UI Health Care Organization

UI Health Care Corporate Services

* Vice President for Medical Affairs Cabinet Member

Associate VP for UI Health AllianceRonald J. Weigel,

MD, PhD

Associate VP for Human Resources

Jana Wessels, JD, MBA

Associate VP for Information

TechnologyLee Carmen, BSEE

Assistant VP for Compliance,

Accredidation and UI Privacy Officer

Deborah Thoman, MA

Assistant VP for Strategic Planning

and Business Development

Christine Miller, MBA

Associate VP for Marketing &

CommunicationsEllen Barron, MS

Vice President for Medical AffairsJean Robillard, MD*

President, University of IowaSally Mason, PhD

Board of Regents, State of Iowa

Associate VP for Nursing

& CNO, UIHCAnn Williamson,

PhD, RN*

Associate VP & CEO, UIHC

Kenneth P. Kates, MBA*

Chief Medical OfficerTheresa

Brennan, MD*

Dean, Carver College of Medicine

Debra Schwinn, MD*

Associate VP for Finance & CFO, UIHC

Ken Fisher, MBA*

Associate VP for Legal Affairs & Legal Counsel,

UIHCBill Hesson, JD*

UI Health Care Board of Advisors


Vice President for Medical Affairs

JEAN E. ROBILLARD, MD

Jean E. Robillard, MD, is vice president for medical affairs at the University of Iowa. He began his appointment as vice president in January 2007, after serving four years as dean of the Carver College of Medicine, a position he continued to hold until June 2008.

Dr. Robillard is charged with integrating planning and operations for UI Health Care, which is comprised of University of Iowa Hospitals and Clinics; the Carver College of Medicine; and University of Iowa Physicians, the state’s largest multi-specialty physician group practice. A powerful resource for Iowa, UI Health Care contributes more than $3.4 billion to the state’s economy and is responsible for over 25,000 jobs in the state.

As leader of Iowa’s only comprehensive academic medical center, Dr. Robillard has created a model for academic medicine in the 21st century and a world class enterprise. Under his vision and leadership, UI Health Care implemented its first strategic plan for the integrated enterprise and expanded medical services to better meet the needs of Iowa’s communities.

Dr. Robillard also has been instrumental in shaping the future of research on campus by championing the John and Mary Pappajohn Biomedical Discovery Building project, which houses both the Pappajohn Biomedical Institute and the Fraternal Order of Eagles Diabetes Research Center. Scheduled for completion in 2014, the facility will be home base for high-risk, high-reward collaborative research aimed at finding cures for complex illnesses.

Dr. Robillard is a pediatric nephrologist whose work focuses on the developmental physiology of the kidney. He has published more than 220 scientific papers during his career and in 2009 was awarded the American Society for Pediatric Nephrology’s Founder’s Award for his unique and lasting contributions to the field.

Prior to his appointment as dean of the Carver College of Medicine, Dr. Robillard served as chair and professor of the Department of Pediatrics at the University of Michigan Medical School and physician-in-chief at C.S. Mott Children’s Hospital.

A native of Montreal, Dr. Robillard earned bachelor’s and medical degrees from the University of Montreal. Following post-doctoral training in Montreal, Los Angeles, and Iowa City, he joined the faculty at the University of Iowa in 1976 as an assistant professor. He was later promoted to professor in 1982, and appointed as vice chair of the Department of Pediatrics in 1987, while he was also director of the Pediatric Nephrology Division.


CEO and Associate Vice President

KENNETH P. KATES, MBA

As the executive leader of UI Hospitals and Clinics and University of Iowa Children’s Hospital, Ken Kates oversees the operational, strategic, and financial performance for the regional referral center.

Kates is focused on providing an extraordinary patient care experience at every level, with a constant eye toward patient safety, clinical excellence, outstanding service, and strong financial performance. He is driven to make sure every patient visit exceeds expectations. Under his leadership, UI Hospitals and Clinics continues to receive recognition on U.S. News & World Report’s list of “The Best Hospitals in America.”

As Associate Vice President, Kates works closely with University of Iowa Health Care leaders to advance UI Health Care’s mission of conducting world class biomedical research, training the next generation of health professionals, and administering unparalleled patient care.

Kates has more than 30 years of experience in academic health care. Prior to coming to Iowa, he held a number of executive positions at the University of Chicago Hospitals and Health System, including Vice President and Director of the University of Chicago Children’s Hospital, Executive Vice President and Chief Operating Officer, and Interim President of the Hospitals and Health System. Before joining the University of Chicago, he held senior positions at Temple University Hospital in Philadelphia.

Kates received a Bachelor of Science degree in business administration/marketing from Philadelphia University, and an MBA in health administration from Temple University’s Fox School of Business in Philadelphia.

Kates serves as a member of the Board of Directors of the University Health System Consortium and maintains an academic appointment in the University of Iowa’s College of Public Health.


Dean, Carver College of Medicine

DEBRA A . SCHWINN, MD

Debra Schwinn, MD, became the new dean of the Roy J. and Lucille A. Carver College of Medicine in 2012. Prior to her appointment at the Carver College of Medicine, Dr. Schwinn was the chair and DEO of the Department of Anesthesiology and Pain Medicine, the Allan J. Treuer Endowed Professor of Anesthesiology, and adjunct professor of pharmacology and genome sciences at the University of Washington in Seattle.

Schwinn is a nationally known investigator in molecular pharmacology with active funding from the National Institutes of Health (NIH). She is an elected member of the Institute of Medicine of the National Academies of Science, and numerous other national and international organizations. She holds four U.S. patents and one Australian patent.

Schwinn has served on numerous national and international committees and boards, including as 2012-2014 chair of the Board of Trustees for the International Anesthesiology Research Society. Schwinn is the author or co-author on more than 180 journal articles and book chapters; the editor of two books; and served as a reviewer on many journals and on the editorial boards of several journals. During her academic career she has received many honorary awards, including several teaching awards.

Schwinn received her medical degree from Stanford University School of Medicine, completed a residency in anesthesiology at the Hospital of the University of Pennsylvania, and a clinical fellowship in cardiac anesthesiology (including training in transesophageal echocardiography) at Duke University Medical Center. She completed a research fellowship in the Departments of Biochemistry and Medicine at Duke, as well as the national Executive Leadership in Academic Medicine program.


THERESA BRENNAN, MD

Chief Medical Officer UI Hospitals and Clinics

Theresa Brennan was appointed chief medical officer for UI Health Care in June 2011. Brennan is also Colloton Associate Professor of Clinical Cardiovascular Medicine. As chief medical officer, Brennan provides leadership in all areas of clinical service, oversees system-wide clinical quality and patient safety, and facilitates clinical performance improvement and best practices to ensure the effective and efficient delivery of care.

Brennan has held a series of leadership roles, including serving as chief resident and chief cardiology fellow, medical director of the cardiovascular inpatient units, vice chair for clinical programs for the Department of Internal Medicine, and co-medical director of UI Heart and Vascular Center. She actively sees and cares for patients in the outpatient clinic, the cardiac catheterization laboratory and the cardiovascular intensive care unit.

Brennan earned a Bachelor of Science degree from the University of Iowa in 1988 and graduated from Northwestern University Medical School in 1992.

KEN L . FISHER, MBA

Associate Vice President for Finance Chief Financial Officer, UI Hospitals and Clinics

Ken L. Fisher was appointed associate vice president for finance with UI Health Care and chief financial officer of UI Hospitals and Clinics in June 2007. Fisher provides financial leadership for each component of UI Health Care and oversees all major financial operations and related personnel within UI Health Care.

Fisher came to the UI from Charlotte, North Carolina, where he was a director for Navigant Consulting Inc., serving as interim chief financial officer and consultant for health care clients in private and academic health care systems. Fisher has more than 40 years of experience in health care financial management, and held financial positions at Grace Hospital in Detroit; East Tennessee Baptist Hospital in Knoxville; Presbyterian Hospital; Charlotte Memorial Hospital and Carolinas Hospital and Health Service, all in Charlotte, North Carolina.

Fisher earned a bachelor’s degree in accounting at Baylor University and a master’s of business administration from the University of North Carolina at Charlotte.

Leadership


WILLIAM W. HESSON, JD

Associate Vice President for Legal Affairs Legal Counsel, UI Hospitals and Clinics

William W. Hesson, JD, was appointed associate vice president for legal affairs in July 2007. He oversees all legal matters for UI Health Care and its components and works closely with UI General Counsel. He serves as associate director/legal counsel at UI Hospitals and Clinics, where he has been a staff member since 1979. Hesson also is an adjunct professor in the College of Public Health at the University of Iowa.

Hesson graduated from the UI College of Law in 1979 and is a member of various organizations, including the Iowa State Bar Association, the American Health Lawyers Association, and the Iowa Society of Health Care Attorneys. He is a former member of the Iowa State Bar Association Health Law Section Council and served as president of the Iowa Society of Healthcare Attorneys from 1993 to 1994.

ANN WILLIAMSON, PHD, RN

Associate Vice President for Nursing and Chief Nursing Officer, UI Hospitals and Clinics

Ann Williamson, PhD, RN, NEA-BC, was appointed associate vice president for nursing and chief nursing officer in February 2008. She oversees nursing services and patient care for the academic medical center.

Prior to joining the UI, Williamson served as patient care director at the University of California, San Francisco (UCSF) Medical Center and as an associate clinical professor at the UCSF School of Nursing. She held a number of leadership positions at UCSF Medical Center, including serving as interim chief nurse, director of nursing education and research, manager of the Emergency Department, and Joint Commission coordinator.

Williamson earned a bachelor’s degree in nursing from the University of North Carolina at Chapel Hill, a master’s degree in nursing from the University of Texas at Austin, and a doctorate from UCSF, with a concentration in nursing informatics and health systems.

RONALD J. WEIGEL , MD, PHD

Associate Vice President UI Health Alliance

Ronald J. Weigel, MD, PhD was named associate vice president for UI Health Alliance in November 2012.

In his role as associate vice president, Weigel works directly with the vice president for medical affairs on development of strategic vision for UI Health Care’s role within the UI Health Alliance, oversee Alliance operations within UI Health Care

Weigel also serves as chair and department executive officer for the Department of Surgery and is a professor of surgical oncology and endocrine surgery.

Weigel received his MD and PhD from Yale University and later received his MBA from The Wharton School at the University of Pennsylvania.


ELLEN BARRON, MS

Associate Vice President for Marketing and Communications

As associate vice president for marketing and communications, Ellen Barron provides strategic leadership and directs all marketing, communications, and external relations activities across UI Health Care’s missions. She oversees internal and external communications, media relations, alumni and collegiate relations, community outreach, as well as marketing services which support new business development initiatives, branding, market research, Internet strategy, and advertising.

Barron has more than 30 years experience as a health care executive. She earned a bachelor’s degree at California State University, Sacramento, and a master’s degree at Bradley University.

LEE CARMEN, BSEE

Associate Vice President for Information Technology

Lee Carmen oversees information technology services across the UI Health Care enterprise.

He joined the UI Carver College of Medicine staff as director of Information Systems in 1994, directing information technology support for academic, research, and administrative initiatives. In 2001, he was named chief information officer and director of Health Care Information Systems for UI Hospitals and Clinics and UI Carver College of Medicine. He is an adjunct instructor in the College of Public Health at the University of Iowa.

Carmen received bachelor’s degrees in microbiology from the University of Oklahoma and in electrical engineering from the University of Iowa.

JANA WESSELS, JD, MBA

Associate Vice President for Human Resources

Jana Wessels is responsible for the strategic direction of the human resources office, which handles all aspects of human resource management for UI Health Care—representing more than 12,000 faculty and staff.

Prior to her appointment as associate vice president she served in an interim role for the position. She had previously been Director of Human Resources for the UI Carver College of Medicine. Before that she had served the UI as director of operations for the Division of Performing Arts in the College of Liberal Arts and Sciences and associate director of Residence Services.

Wessels holds JD and MBA degrees from the University of Iowa.


CHRISTINE MILLER, MBA

Assistant Vice President for Integrated Strategic Planning and Business Development

Christine Miller was appointed Assistant Vice President for Integrated Strategic Planning and Business Development in 2007.

She oversees the development and implementation of strategic vision in the marketplace, including managing Physician Relations, Corporate Relations and Business Development, and UI Health Plans.

Miller graduated from the University of Iowa with a degree in general science and a certificate in physical therapy. She received her MBA from the University of Denver.

SABI SINGH, MS, MA

Assistant Vice President for Operational Excellence and Quality/Safety

Sabi Singh was named Assistant Vice President for Operational Excellence and Quality/Safety in December 2007. He focuses on achieving institutional excellence in all areas.

In addition to Operational Improvement, Singh leads Clinical Quality Safety and Performance Improvement and the Materials Management/Supply Chain function for UI Hospitals and Clinics.

Singh joined UI Hospitals and Clinics as director of operations improvement in July 2005. He is also an adjunct instructor in the College of Public Health at the University of Iowa.

DEBORAH THOMAN, BA , BS, MA

Assistant Vice President for Compliance, Accreditation and UI Privacy Officer

Debbie Thoman was named assistant vice president for compliance, accreditation, and UI privacy officer in September 2008. She directs the overall administration and provision of services, programs, and staff functions for the compliance and accreditation activities for UI Health Care. She also directs activities related to programs and functions as the Health Insurance Portability and Accountability Act Privacy Officer for the University of Iowa.

Previously, Thoman served as director of health information management and most recently as senior assistant director, compliance/privacy officer, Joint Office for Compliance.


University of Iowa Health Alliance

UI Health Care established an alliance with 3 other health care systems

in June of 2012, called University of Iowa Health Alliance. The other

systems in the alliance are Mercy Health Network, Genesis Health System

and Mercy Cedar Rapids. The goals of the Alliance are:

Develop a strong statewide network

• Establish a network of quality providers to serve a substantial portion of Iowa

• Increase physician alignment through a broadened primary care and specialist network

• Create an organizational model for other healthcare providers to join the network

• Honor local governance and preserve/enhance the mission of each participating organization in serving the needs of their respective communities

• Grow the total market share and total revenue, consistent with anti-trust laws

Reduce per capita health care costs

• Develop an efficient vehicle to enable cooperative work to produce fundamental value

• Create economies to reduce cost per discharge

Improve the health of populations

• Create the infrastructure (e.g., data warehouse, HIE) to assume risk for population health and respond to changes in healthcare payments and regulations

• Engage with patients in new ways to better manage chronic disease & promote health

Enhance the health care experience

• Establish a distinctly recognized brand differentiated by a service experience that is fully recognized as “the” standard in Iowa – seamless, well-coordinated care.


MERCY HEALTH NETWORK UI HEALTH CARE GENESIS HEALTH SYSTEM MERCY CEDAR RAPIDS

MHN Medical Centers (11)

University of Iowa Hospital (5)

Genesis Health System (5)

Mercy Cedar Rapids

MHN Physician Clinic (142)

Physician Clinic UI Health Care (5)

Genesis Health Physician Clinic (44)

MercyCare Physician Clinic (20)

MHN Affiliate Hospital (27)

UI Affiliate Hospital (10)

Genesis CAH Mercy Cedar Rapids Affiliate

Integrated Physicians: 625 Integrated Physicians: 1,432 Integrated Physicians: 167 Integrated Physicians: 82

The alliance has worked closely together over the last year, making significant progress on these goals through the Board of Directors as well as workgroups for clinical integration, Contracting Innovation and Marketing/Communications, with active participation from all member organizations.

Initial Alliance Members, Affiliates, and Physicians

Carver College of Medicine


Roy J. and Lucille A.Carver College of MedicineState-supported medical education in Iowa traces back to

the winter of 1850-51, when the state legislature recognized

the Keokuk College of Physicians and Surgeons as the

official medical department of the State University of Iowa.

The Keokuk College had begun operations a year earlier as the College of Physicians and Surgeons of the Upper Mississippi in Davenport, graduating 15 physicians before its move to Keokuk. It would continue to operate the state-sponsored medical college for another 20 years, and as an independent institution for an additional 40 years.

In the late 1860s, a prominent Davenport surgeon named Washington Freeman Peck initiated efforts to create a medical college in Iowa City. With support from Judge John F. Dillon (a patient of Peck’s and a graduate of the original Davenport medical college) and the Honorable John P. Irish (Iowa City newspaper editor, state legislator, and a member of the university board of trustees), the Iowa City medical department gained approval as the official university medical college in 1870. The UI college was a founding member of the Association of American Medical Colleges in 1876.

The college opened doors for its first class on Sept. 20, 1870. The faculty consisted of eight professors, including Washington Peck as dean and professor of surgery, and Judge Dillon as a professor of medical jurisprudence. The first class consisted of 37 students, including eight women. The Iowa College of Medicine thus became the first public institution in the country to admit women to its class. The curriculum for the first class consisted of a two-week course of lectures followed by 16 weeks of clinical training.

CARVER COLLEGE OF MEDICINECHANGING MEDICINE. CHANGING LIVES. 61

The College Today

The University of Iowa Roy J. and Lucille A. Carver College

of Medicine is a nationally ranked medical school with

exceptional balance across its three missions of research,

education, and clinical care. It was founded in 1870 and

was the first public medical school in the country to admit

women on an equal basis with men.

The college’s annual budget is more than $600 million, and it employs over 1,000 faculty and more than 1,700 staff. The faculty teaches 640 medical students, 972 resident and fellow physicians, 200 associated medical science students, and 5,000 undergraduate students.

U.S. News & World Report consistently ranks the college among the nation’s best. In 2012 the college ranked 16th among medical schools in primary care and 28th in research. Its physician assistant training program ranked second and its physical therapy program ranked fifth. Other top rankings included rural medicine (9); family medicine (16); and internal medicine (17).

The buildings housing the Carver College of Medicine are the centerpieces of a recently redesigned health sciences campus which includes a pedestrian-friendly commons and a functional and stimulating environment for students, faculty, and staff. Among the college facilities are three of the most forward-looking building projects in UI history—the Medical Education and Research Facility, Carver Biomedical Research Building and Pappajohn Biomedical Discovery Building.

Medical students participating in a clinical beginnings course.


Carver College of Medicine Organization

Assistant Dean, Cultural Affairs &

DiversityDenise Martinez, MD

Associate Dean, Cultural Affairs &

DiversitySherree Wilson, PhD

Associate Dean for Clinical Affairs and UI

Physicians LeaderDouglas Van Daele, MD

Administrator for Programs, Centers,

InstitutesKathleen Barbee, MEd

UI Health Care Corporate Services



Vice President for Medical AffairsJean Robillard, MD

Provost, University of IowaP. Barry Butler, PhD

Dean, Carver College of MedicineDebra Schwinn, MD

Department Chairs

Chief of Staff, Dean’s Office

Sheila Goins, PhD, MBA

Executive Associate Dean

Donna Hammond, PhD

Director, Consultation & Research in Medical

EducationKristi Ferguson, PhD

Director, Continuing Medical Education

Susan Zollo, MA

Assistant Dean & Director, Statewide Clinical Education

ProgramsRoger Tracy, MS, MA

Associate Dean, Information Technology

Boyd Knosp, MS

Assistant Dean, Student Affairs & Curriculum, Des

Moines Branch CampusSteven Craig, MD

Assistant Dean, Student Affairs &

CurriculumNancy Rosenthal, MD

Assistant Dean, Student Affairs &

Curriculum David Asprey, PhD, PA

Assistant Dean for Administration &

Director, Facilities Planning &

ManagementJim Henderson, MA

Associate Dean, Graduate Medical

EducationMark Wilson, MD, MPH

Associate Dean, Student Affairs &

CurriculumChris Cooper, MD

Associate Dean, Faculty Affairs &

DevelopmentLois Geist, MD

Senior Associate Dean, Scientific Affairs

Vacant

Associate Dean, Clinical & Translational

SciencePat Winokur, MD

Associate Dean, Clinical Affairs

Vacant


DONNA HAMMOND, PHD

Executive Associate Dean Carver College of Medicine

Donna L. Hammond, PhD, is the interim executive associate dean of the Carver College of Medicine. As interim executive associate dean, Hammond oversees collegiate administration, coordinates planning and capital projects, and represents the dean in various capacities.

Hammond is also a professor in the Departments of Anesthesia and Pharmacology and directs the Pain Research Program.

The goal of Hammond’s research program is to gain a better understanding of the central nervous pathways that convey pain.

Hammond joined the UI faculty in 2000. She received her PhD at the University of Illinois at Chicago and completed a postdoctoral fellowship at the Mayo Clinic in Rochester, Minnesota.

SHERREE WILSON, PHD

Associate Dean for Cultural Affairs and Diversity Initiatives

Sherree A. Wilson, PhD, is the associate dean for cultural affairs and diversity initiatives. Appointed in July, 2012, Dr. Wilson is responsible for leading the assessment and implementation of diversity initiatives throughout the college.

Prior to coming to the University of Iowa, Dr. Wilson served in a variety of roles with Indiana University Purdue University Indianapolis (IUPUI), including Special Assistant to the Chancellor and Assistant Dean of the Faculties.

Dr. Wilson has a BS degree in Speech Pathology & Audiology from Ball State University, a M.S. degree in College Student Personnel Administration & Counseling from Indiana University (IU), and a PhD in Higher Education Administration from IU.

CHRISTOPHER COOPER, MD

Associate Dean for Student Affairs and Curriculum

Christopher Cooper, MD, is associate dean for student affairs and curriculum. Cooper also serves as professor and vice chair in the Department of Urology and directs the Division of Pediatric Urology.

As associate dean, Cooper provides guidance for the medical degree program and coordination of that program with combined degree programs, such as the Medical Scientist Training Program.

Cooper earned a bachelor’s degree, medical degree, and completed a residency in urology at the University of Iowa. He completed a fellowship at the Children’s Hospital of Philadelphia. Cooper joined the UI faculty in 1999.

College Leadership


LOIS GEIST, MD

Associate Dean for Faculty Affairs and Development

Lois Geist, MD, is associate dean for faculty affairs and development. Geist also serves as a professor of internal medicine in the Division of Pulmonary, Critical Care and Occupational Medicine. As associate dean, Geist provides resources and advises faculty on issues of career development, with a strong focus on junior faculty and leadership development. Her office has also established a program serving the needs of women in medicine and science.

She earned her medical degree at Case Western Reserve University in Cleveland, Ohio. She completed a residency in internal medicine at University Hospitals of Cleveland followed by a fellowship in pulmonary diseases at the University of Iowa Hospitals and Clinics. She joined the UI faculty as an assistant professor in 1991.

BOYD KNOSP, MS

Associate Dean for Information Technology

Boyd Knosp, MS, is associate dean for information technology.

As associate dean, Knosp provides leadership and sets the strategic direction for IT that supports the research and academic missions of the college.

Knosp holds bachelor’s and master’s degrees in electrical and computer engineering from the University of Iowa. He previously served as manager of research services with UI Information Technology Services.

MARK WILSON, MD, MPH

Associate Dean for Graduate Medical Education

Mark C. Wilson, MD, MPH, is associate dean for graduate medical education and clinical professor of internal medicine.

Wilson has served as the physician director of graduate medical education since 2004. He has served as the associate residency directory in internal medicine, participated in numerous clinical and teaching activities; and led various institutional committees. Wilson has also developed initiatives to support and develop graduate medical education program directors and to enhance the educational environment for residents and fellows.

Wilson earned a medical degree at Texas Tech University, completed his residency at Wake Forest University, and a fellowship at Johns Hopkins Medical School.


PATRICIA WINOKUR, MD

Associate Dean for Clinical and Translational Science

Patricia Winokur, MD, is associate dean for clinical and translational science and professor of internal medicine.

Her research focuses on studying the molecular basis of antibiotic resistance, creating a model for Hemophilus influenzae that can be used to study vaccines in early development, and leading a number of vaccine trials. Winokur is UI principal investigator for a seven-year, $23.7 million National Institutes of Health contract to conduct clinical trials of promising vaccines and therapies for infectious diseases.

Winokur has been a UI faculty member since 1993. She earned a medical degree from Washington University. Winokur completed a residency in internal medicine and a fellowship in infectious diseases at the University of Iowa.

DOUGLAS VAN DAELE, MD

Associate Dean for Clinical Affairs and Physician Leader, UI Physicians

Douglas Van Daele is associate dean for clinical affairs as well as the physician leader for UI Physicians, and chief medical information officer for UI Hospitals and Clinics.

In his role as chief medical information officer, Van Daele played an integral role in the successful transition to th eelectronic medical record (Epic) and helped to incorporate Epic medical records in University of Iowa Health Alliance partner locations, improving UI Health Care’s ability to coordinate care and examine system wide outcomes.

Van Daele received his BSE in engineering and his medical degree from the University of Iowa. He also completed his surgical internship, laryngology research fellowship and otolarngology residency at UI Hospitals and Clinics.

DAVID ASPREY, PHD, PA-C

Associate Dean for Graduate Medical Education

David Asprey, PhD, PA-C, is an assistant dean for student affairs and curriculum. Asprey also serves as the chair and DEO of the Department of Physician Assistant Studies and Services. Previously, Asprey directed the Physician Assistant Program since 1997. He is also an active member of the Department of Emergency Medicine and Division of Pediatric Cardiology.

He received his bachelor’s degree in biology and MPAS from the University of Iowa. Asprey also completed a master’s degree in education and his PhD in higher education, planning policy, and leadership studies.


STEVEN CRAIG, MD

Assistant Dean for Student Affairs and Curriculum

Steven R. Craig, MD, is assistant dean of student affairs and curriculum, with responsibilities for academic operations at the Des Moines Consortium Branch Campus.

In addition to leading the branch campus, Craig serves as executive director of the Des Moines Area Medical Education Consortium, which was established in 1994 as an educational organization with an exclusive academic affiliation with the University of Iowa. He is also an internal medicine physician in Des Moines, Iowa.

Craig is an alumnus of the University of Iowa and the UI Carver College of Medicine. Following medical school, he completed his internship and residency at the University of Colorado Health Sciences Center in Denver, Colorado.

DENISE MARTINEZ , MD

Assistant Dean for Cultural Affairs and Diversity Initiatives

Denise Martinez, MD, is the assistant dean for cultural affairs and diversity initiatives in the Carver College of Medicine. Dr. Martinez is also a clinical assistant professor in the Department of Family Medicine, with professional interests including cultural competence education, chronic disease management, and women’s health obstetrics. She received her MD from Tufts University School of Medicine and completed herresidency at University of Iowa Hospitals and Clinics.

NANCY ROSENTHAL , MD

Assistant Dean for Student Affairs and Curriculum

Nancy Rosenthal, MD, is an assistant dean for student affairs and curriculum.

Rosenthal is also a professor in the Department of Pathology where she serves as the director of the Hematology laboratory. She is interested in all aspects of diagnostic hematology automation, coagulation, and particularly bone marrow pathology.

She is actively involved in the Department of Pathology as vice chair for education, director of the hemopathology fellowship program, and director of hematology residency education.

Rosenthal received her medical degree from the University of Pennsylvania School of Medicine and completed a residency and hematopathology fellowship at University Hospitals of Cleveland.


KRISTI FERGUSON, PHD

Director, Consulting and Research in Medical Education

Kristi Ferguson, PhD, is the director of the Office of Consulting and Research in Medical Education.

The office provides coordination of services and products that support curriculum development, faculty development, measurement, evaluation and educational research.

Ferguson’s teaching interests include small group facilitation, presentation skills, strategies for motivating patients, and test item writing. Her current research projects include an assessment of written learning issue reports in case-based learning, evaluation of the “students teaching students” approach in gross anatomy, and assessment of a standardized clinical rating system.

She received her master’s degree and PhD from the University of Michigan.

SHEILA GOINS, PHD, MBA

Chief of Staff,Office of the Dean

As chief of staff, Shelia Goins, PhD, MBA coordinates and assists with the implementation of strategic priorities of the dean of the Carver College of Medicine, monitors central and departmental budgets, and provides communication support for the dean as well as all assistant and associate deans.

Dr. Goins previously served as an assistant professor of marketing at the UI Tippie College of Business.

She received a master’s degree in health policy and management from Harvard University School of Public Health; and an MBA with Honors and a PhD in organization theory and strategy from the University of Chicago Graduate School of Business.

SUSAN ZOLLO, MA

Director,Continuing Medical Education

Susan Zollo, MA, is the director of the Office of Continuing Medical Education.

The Office of Continuing Medical Education actively works to strengthen the knowledge and clinical practice expertise of physicians that translates into the best possible health care of their patients. The office also strives to meet the educational needs of physicians in a rapidly evolving health care environment with continuous major technological changes.

Zollo received her MA from the University of Iowa. She has served as Director of the Office of Continuing Medical Education since 2004.


People

Faculty Diversity

FACULTY TYPE TOTAL FEMALE MALE

MINORITY

RACIAL / ETHNIC WHITE UNKNOWN

Tenure Track 503 109 394 68 419 16

Clinical / Research or Other

507 220 287 107 361 39

Basic and Clinical Faculty

918 Clincial Faculty

92 Basic Science Faculty

1,010 Total Faculty

503 Tenure Track

410 Clinical Track4

97 Research Track / Other

1,010 Total Faculty


Education


students learn to become

accomplished clinicians and top-

flight researchers. Students who

come to Iowa to study medicine

join a community where case-

based learning is the basis

of their education.

With its emphasis on problem-solving skills, early exposure to patients, and enhanced community-based experiences, UI medical students typically have earned impressive scores on Step 1 of the U.S. Medical Licensing Examination and successfully “match” with top-quality residency programs.

Each of the medical and physician assistant students belongs to one of four “communities” in which he or she interacts with students in each year of the programs. This provides students with a more intimate, personal, and supportive learning environment.

Education and training from the college extends far beyond medical students and the University of Iowa campus.

It falls broadly into seven categories listed at right.

Programs of Education

Undergraduate Medical Education

Graduate Medical Education

Other Health Professional Education

Undergraduate Science Education

Graduate Education in Science

Clinical Training for Health Professionals

Continuing Medical Education

Students perform toddler exams.

A medical student community.


Education

Programs of Education at the Carver College of MedicineUndergraduate Medical EducationThere are 583 medical students in the Carver College of Medicine. Students may elect to pursue a distinction track in humanities, global health, teaching, service, or research. The Carver College of Medicine undergraduate medical program ranked 7th by the American Academy of Family Physicians for graduating the greatest percentage of students and in 2010 was ranked 10th in the nation by the American College of Physicians for accomplishing the social mission of academic medicine—graduating students who practice primary care, work in underserved areas, and represent the diversity of the population.

Graduate Medical EducationAt any given time, there are more than 700 doctors participating in graduate medical education at the University of Iowa. The impact of UI Health Care’s education mission on Iowa is significant, one-half of Iowa’s 5,000 doctors did some or all of their training at the University of Iowa.

Other Health Professional EducationIn addition to medical students, UIHC trains physician assistants and physical therapists and offers programs in dietetics, nuclear medicine technology, perfusion, radiation sciences, radiation therapy, radiologic technology, diagnostic medical sonography, and other health professions.

Undergraduate Science EducationAbout 5,000 undergraduate students from across the UI take courses in physiology and biophysics, biochemistry, anatomy and cell biology, and other basic sciences at the Carver College of Medicine.

Graduate Education in ScienceThe college’s research laboratories are the training grounds for more than 250 graduate students who pursue biomedical research under the mentorship of Carver College of Medicine faculty. The University of Iowa grants 60 doctorates each year to graduate students in the basic sciences. Routinely, over two-thirds of UI medical students graduate after participating in at least one research experience.

Clinical Training for Health ProfessionalsUniversity of Iowa Health Care provides professional education and training for a range of health care professionals, including nursing students from the UI College of Nursing and local community colleges, as well as UI Pharmacy students who gain clinical experience at University of Iowa Hospitals and Clinics.

Continuing Medical EducationUI Health Care practitioners present 200 CME programs annually to more than 5,000 physicians and an equal number of other professionals. Education takes place well beyond the campus in Iowa City. University of Iowa Health Care also participates in an education consortium in six Iowa cities: Des Moines, Waterloo, Mason City, Sioux City, Davenport, and Cedar Rapids.

Medical students fan out across the state to learn from local doctors who serve as the Carver College of Medicine’s 700 community-based faculty. In addition, Iowans who are interested in health care issues can participate in Mini-Medical School programs, community seminars, and obtain information about diseases, treatments, and other topics through programs such as the Cancer Information Service.


Degree Programs Combined Degree ProgramsThrough partnerships with several other UI colleges, the Carver College of Medicine offers programs for combined degrees of MD/MBA, MD/MPH, MD/PhD, and MD/JD.

Doctor of Philosophy (PhD)Several departmental graduate programs as well as interdisciplinary studies and a multidisciplinary entry program.

Doctor of Physical Therapy (DPT)The graduate program in physical therapy and rehabilitation science offers a unique learning environment with resources available to complement missions of excellence in teaching, research, and clinical service.

Doctor of Medicine (MD)The MD program offers a vital, dynamic curriculum mindful of the needs of a changing society.

Masters in Medical Education (MME)The master’s in medical education degree seeks to develop a community of academic medical faculty with formal training in education.

A certificate program is also available.

Medical Scientist Training Program (MD, PhD)The Medical Scientist Training Program provides training for both the MD and PhD degrees in an environment that integrates graduate research training with clinical studies.

Physician Assistant (PA)The innovative physician assistant curriculum is intricately woven into a creative matrix of courses that prepares students to move far beyond simple memorization of facts and figures to developing skills designed to prepare them as lifelong learners.

Master of Science (MS)Similar to PhD studies, several departmental and interdisciplinary programs exist, as well as a multidisciplinary entry program.

A presentation during a continuing medical education activity.


Research

The research enterprise of the UI Carver College of Medicine garnered

more than $209.5 million in external funding in fiscal year 2012. The UI

currently ranks tenth among public institutions and third among Big Ten

medical schools in National Institutes of Health (NIH) funding. UI Carver

College of Medicine faculty are also some of the most productive when

measured by NIH dollars.

UI Carver College of Medicine faculty are also some of the most productive when measured by NIH dollars.

The research enterprise is overseen by Patricia Winokur, MD, associate dean for clinical and translational sciences. Robert Piper, PhD, directs the UI Carver College of Medicine’s core research facilities.

Many college faculty members are internationally renowned for their research. Four faculty members are Howard Hughes Medical Institute investigators, 17 are members of the Institute of Medicine, and three are members of the National Academy of Sciences.

OPPORTUNITIES FOR STUDENTS

The college’s thriving research enterprise offers a variety of opportunities to students. The Iowa Medical Student Research Program seeks to support, promote, and raise awareness about medical student research opportunities at the UI. Medical students who pursue a more in-depth research experience are recognized at graduation with a Research Distinction designation on their diploma. The Medical Scientist Training Program (MSTP), a combined MD-PhD degree funded by the National Institutes of Health, offers a training sequence that integrates graduate study, research training, and all clinical studies required for the medical degree.

Graduate students at work in one of the College’s many labs.


$50M

$100M

$150M

$200M

FY 2008 FY 2009 FY 2010 FY 2011 FY 2012

Fiscal Year Total Awards Federal Awards Private Non-Profit Industry Subawards Other

FY 2009 $212,526,129 $154,097,581 $27,690,700 $16,766,697 $9,861,417 $4,109,734FY 2010 $228,158,345 $174,477,252 $21,939,530 $15,281,433 $13,281,895 $3,178,235FY 2011 $229,472,395 $161,914,490 $27,134,879 $20,498,178 $14,044,873 $5,879,975FY 2012 $209,495,606 $142,260,726 $21,947,991 $29,923,314 $12,297,034 $3,066,541FY 2013 $225,399,265 $139,218,958 $28,926,844 $41,930,269 $13,228,583 $2,094,610

Fiscal Year Federal Awards Other Industry Subawards Private Non-Profit

FY 2009 1017 30 282 250 425FY 2010 804 22 239 230 401FY 2011 704 24 283 224 389FY 2012 797 32 233 249 433FY 2013 767 27 259 254 439

College of Medicine Research Grant and Contract Applications Submitted by Funding

College of Medicine Sources of Research Funding

500

1000

1500

2000

FY 2009 FY 2010 FY 2011 FY 2012 FY 2013


Research

Centers and Institutes

Aging, Center onAuditory Regeneration and Deafness, Center forBioinformatics and Computational Biology, Center forCancer Center, Holden ComprehensiveCardiovascular Research CenterClinical and Translational Science, Iowa Institute for Craniofacial Research CenterCystic Fibrosis Research CenterDiabetes Research Center, Fraternal Order of EaglesFunctional Genomics of Hypertension, Center forGeneral Clinical Research CenterHuman Genetics, Iowa Institute of Huntington’s Disease Society of America Center of ExcellenceImmunology and Immune-based Diseases, Center forKidney Research Center, George M. O’BrienLung Imaging Center, Iowa ComprehensiveMacular Degeneration, Carver Family Center for Muscular Dystrophy Cooperative Research Center,Senator Paul D. WellstoneOsteoarthritis, Specialized Center of Research inPappajohn Biomedical Institute, University of IowaViral Pathogenesis, Helen C. Levitt Center forVision Research, Institute for

Research Programs

Program Project Grant on AtherosclerosisBacterial RespiratoryPathogens Research UnitCancer and Aging ProgramCerebral Vascular Biology ProgramProgram in Gene DiscoveryResearch Program inGenetics of PrematurityInflammation ProgramPain Research ProgramNIH Vaccine Treatment and Evaluation Unit

Core Research Facilities

Office of Animal ResourcesBiochemistry StoresBioengineering Services Bioinformatics FacilityBiosafety Level III LaboratoriesBiomedical Research StoreCenter for Biocatalysis and BioprocessingCentral Microscopy Research FacilitiesComparative Pathology LaboratoryCrystallography FacilityDNA FacilityElectron Spin Resonance FacilityFlow Cytometry FacilityGene Transfer Vector Core FacilityHigh Resolution Mass Spectrometry FacilityHistology Research LaboratoryHybridoma FacilityLarge-scale Digital Cell Analysis SystemMagnetic Resonance Research FacilityNuclear Magnetic Resonance FacilityProtein FacilityProteomics FacilityRadiation and Free Radical Research FacilitySmall Animal Imaging FacilityTissue Procurement Core FacilityTransgenic and Genome Manipulation Facility

University of Iowa Hospitals and Clinics


University of Iowa Hospitals and ClinicsThe first fully autonomous University Hospital opened in

1898 in the building now called Seashore Hall. The building’s

“H” shape, which kept patients segregated in separate wings,

was evidence that modern ideas about disease transmission

were beginning to inform medical science in Iowa.

In 1919 a Children’s Hospital opened on the west side of the Iowa River. This building was the first in a new west side medical complex, and its opening was marked by an official name change from “University Hospital” to “University Hospitals.”

A 60-bed Psychopathic Hospital was added in 1921 and, with matching funds from the Rockefeller Foundation, a new, modern General Hospital was opened in 1928.

The seven-story building had 750 beds, a 300-seat surgical amphitheater, and a 143-foot Gothic tower made of Indiana limestone. Thirteen hundred and 50 feet of tunnels connected the building with the adjacent Medical Laboratories and the Psychopathic and Children’s Hospitals, making the new hospital the center of the 80-acre medical complex.

In the 1970s, a long-range, phased program began to modernize patient care facilities in this state-owned institution without requiring state-appropriated capital funds. Today’s 692-bed facility provides patients with access to world class health care.

UNIVERSITY OF IOWA HOSPITALS AND CLINICSCHANGING MEDICINE. CHANGING LIVES. 77

UI Hospitals and Clinics Today

As part of UI Health Care, University of Iowa Hospitals and Clinics

offers care and hope to patients, discovers new ways to treat disease,

and trains tomorrow’s health professionals These missions are carried

out in collaboration with the UI Roy J. and Lucille A. Carver College of

Medicine and UI Physicians.

As a leading teaching hospital with a full range of specialty care, UI Hospitals and Clinics serves as a regional referral center, attracting patients from across the state and the U.S., as well as many other nations.

The comprehensive academic medical center houses the Hawkeye State’s only National Cancer Institute-designated comprehensive cancer center, its only Burn Treatment Center, its highest rated neonatal intensive care unit, the most comprehensive transplantation program in Iowa, and its only Level I adult and pediatric trauma service.

Other areas of strength include oncology, the multi-specialty expertise of the neurosciences, and the UI Heart and Vascular Care Center, which includes a full range of medical and surgical specialists using the latest techniques and technologies, including TAVR and the Total Artificial Heart.

With 692 inpatient beds, UI Hospitals and Clinics and its 7,400 health professionals annually care for over 30,000 acutely ill children and adults. Faculty and staff also provide high-quality care during nearly 932,000 clinic visits each year.

UI Hospitals and Clinics has a long history of innovation and advancement, having pioneered the heart-lung machine, performed the first horizontal gastroplasty surgery for morbid obesity, implanted the first multi-channel cochlear implant in the U.S., established the world’s first bone marrow registry, pioneered pediatric robotic surgery, and performed the world’s first magnetically guided lung procedure using Stereotaxis.®


Chief Nursing Officer (CNO)

Ann Williamson, RN, PhD

Associate Director & Associate CNOKenneth Rempher,

RN, PhD

Chief Medical Officer (CMO)

Theresa Brennan, MD

Associate CMO / Chief Quality Officer

Vacant

Associate CMO / Critical Care

Greg Schmidt, MD

Associate CMO / Chief Quality Officer, UIHCErik Edens, MD

Associate CMO / Chief Patient Safety

OfficerMichael Miller, MD

Co-Chief Operating Officer (COO)

(Interim) & Executive Director, UI Children’s

Hospital

Assistant Director

Vacant

Associate Director

Vacant

Associate Director

Vacant

Corporate Services



Vice President for Medical AffairsJean Robillard, MD

Chief Executive Officer, UIHCKenneth P. Kates

- Admin. Fellowships - Volunteers

Administrative Chief of Staff

(Interim)Garen Carpenter

Co-Chief Operating Officer (COO)

(Interim)Sabi Singh

Associate Director

Vacant

Associate Director

Laurance Reed

Senior Assistant Director

Amy O’Deen

Associate Director & Chief Pharmacy

OfficerMichael Brownlee,

PharmD

Associate Director & Executive Medical

DirectorRami Boutros, MD

Graduate Medical Education

Mark Wilson, MD (with CCOM)

Medical Chief of Staff

Victoria Sharp, MD

- Compliance (Thoman)

- Finance (Fisher)

- HCIS (Carmen)

- Human Resources (Wessels)

- Legal (Hesson)

- Marketing (Barron)

- Strategic Plan (Miller)

Senior Associate Director

Jon Staley, PhD

UI Hospitals and Clinics Organization


Recognition

U.S. News & World Report magazine

consistently ranks UI Hospitals and Clinics

among “America’s Best Hospitals.” In the most

recent survey, ophthalmology ranked in the

top 10 and five others—cancer, neurology and

neurosurgery, orthopedics, otolaryngology,

and nephrology ranked in the top 50 for their

respective categories.

In 2013 the “Best Doctors in America” database recognized more than 280 UI physicians, over half of the individual Iowa physicians listed on the nationwide database.

Additionally, in 2012 a total of 151 doctors from UI Hospitals and Clinics were nominated for the U.S. News & World Report’s directory of top physicians in the United States.

Other recognition received by UI Hospitals and Clinics includes:

• First Iowa hospital to be designated as a Magnet Hospital for Nursing Excellence, and first hospital to be re-designated

• Certified as a Level I (highest) Trauma Center for both children and adults

• Verified for burn care by the American College of Surgeons and the American Burn Association

• Wellmark Blue Distinction CenterSM in five areas: cardiac care, bariatric (weight loss) surgery, complex and rare cancers, adult bone marrow transplant, and assisted reproduction quality program

• Joint Commission Gold Seal of ApprovalTM as a Primary Stroke Center


University of Iowa Children’s Hospital

UI Children’s Hospital has been

dedicated to meeting the health

care needs of children and families

for more than 90 years. As Iowa’s only comprehensive children’s hospital and academic medical center, hospital faculty and staff also perform groundbreaking research to help solve the mysteries of childhood diseases, as well as educate and train the next generation of pediatric health care professionals.

The University of Iowa Children’s Hospital is part of UI Health Care and operates 194 beds.

UI Children’s Hospital features more than 40 pediatric specialties, 140 pediatric physicians and surgeons, and more than 500 specially trained pediatric nurses.

In fiscal year 2012, UI Children’s Hospital cared for 6,228 hospitalized children, performed 4,931 surgeries, and provided 208,959 outpatient visits. It was ranked one of the nation’s Best Children’s Hospitals by U.S. News & World Report in all 10 possible specialties. It has also been ranked number 20 among all 170 children’s hospitals by Parents magazine.

Through a partnership with the state of Iowa and others, the hospital also provides 12 Child Health Specialty Clinics located throughout Iowa to serve children with complicated health issues and chronic conditions.

Currently, UI Children’s Hospital is a “hospital within a hospital,” residing within the UI Hospitals and Clinics complex. Construction is currently under way for a new, free-standing UI Children’s Hospital that will be connected to the UI Hospitals and Clinics complex. The new building will contain over 370,000 gsf on 11 floors of new construction and over 56,000 gsf of renovated existing space. The project is currently slated for completion in March 2016.


Other Clinical Facilities

The Institute for Orthopaedics, Sports Medicine, and Rehabilitation

The Institute for Orthopaedics, Sports Medicine, and Rehabilitation, located just off of Mormon Trek Boulevard, is home to state-of-the-art clinical and rehabilitation facilities. The 26,000-square-foot building includes 16 examination rooms and four treatment rooms.

Almost 7,500 square feet is devoted to comprehensive rehabilitation services, including a hydrotherapy pool, custom orthotics, athletic shoe wear modification, and bracing, training aids, and rehabilitation accessories.In addition, the facility houses other medical specialties, including children’s injuries and orthopaedic clinics devoted to treating disorders of the hand,

UI Health Care Clinics

UI Health Care offers a broad range of health care services and specialties through a network of off-campus UI Health Care locations in an eight county area, including three walk-in UI QuickCare locations and cancer services

OTHER IOWA LOCATIONS

UI Health Care—Belle PlaineUI Health Care—LowdenUI Health Care—MuscatineUIealth Care—River CrossingUI Health Care—SigourneyUI Health Care—Wapello

JOHNSON COUNTY LOCATIONS

UI Health Care—Southeast Iowa CityUI Health Care—North LibertyUI QuickCare—CoralvilleUI QuickCare—East Iowa CityUI QuickCare—Old Capitol Town Center in

Iowa River Landing- Coralville

Open since October 2012, UI Health Care—Iowa River Landing provides increased access to patients for primary and specialty care. Located just off Interstate 80 in Coralville, Iowa, this five-level clinical office building is the new home for General Pediatric and General Internal Medicine physicians.

In addition, several specialty clinics have space in the facility, including cardiology, ophthalmology, otolaryngology, urology, and women’s wellness.

There are approximately 100 exam rooms, onsite hearing testing, a pathology laboratory, and radiology services available—including CT scan, mammography, X-ray, and ultrasound.

Also available are several services for patients, including the cardiac rehabilitation program CHAMPS, outpatient pharmacy, optical shop, and hearing aid center.

Future Facilities

UI Health Care leaders have begun planning for other off-campus clinical facilities, including:

• A Family Medicine outpatient facility on Melrose Avenue in Iowa City.

• A community-based primary care site in North Liberty.


Hospital Service RecordUI Hospitals and Clinics recorded more than 977,000 clinic visits during the 2012 fiscal year, including more than 159,000 visits outside Iowa City at outreach and UI Family Care sites. As the state’s only comprehensive academic medical center, this record of service to the state documents numbers related to all three of our missions—patient care, education and research.

BedsIntensive Care 157

Acute Care 552

Non-acute Care 2

Total Inpatient Beds 711

Education ProgramsMedical Students 656

Dental Students 76

Nursing Students 610

Pharmacy Students 259

Resident and Fellow Physicians and Dentists in Training 736

Other Iowa Health Profession Students in Training 1,700

Total in Health Education at UI Hospitals and Clinics 4,037

Hospital Human ResourcesStaff Physicians and Dentists 812

Resident Physicians and Dentists 534

Fellow Physicians 202

Professional Nurses 1,845

Other Professional Staff 2,080

Other Hospital Staff 2,748

Total Hospital Staff 8,221

Patient Services ADMISSIONS, VISITS, DAYS OF CARE

Acute Adult and Children Admissions 30,537

Newborn Nursery 1,550

Total Acute Admissions 32,087

Acute Adult & Children Patient Days of Care 195,262

Newborn Nursery 3,229

Total Acute Patient Days of Care 198,491

UI Hospitals and Clinics Clinic Visits 818,178

Outreach, UI Community Medical Services (UICMS) Clinic Visits 159,159

Total Clinic Visits 977,337

Emergency-Trauma Center Visits 59,889


PROCEDURES

Births 1,950

Cardiac Catheterization Procedures

Adult 8,174

Child 1,475

Total Cardiac Catheterization Procedures 9,649

Cardiac Electrophysiology Studies 3,250

Cochlear Implant Procedures 93

Digestive Disease Procedures 18,867

Fetal Diagnosis and Therapy Procedures 267

In Vitro Fertilization / Related Procedures 930

TREATMENTS

Days of Ventilator Care 25,967

Hyperbaric Oxygen Treatments 2,892

Radiation Oncology Treatments 46,390

Renal Dialysis Treatments 25,853

SURGERIES

Major Surgical Operations 27,875

Minor Surgical Operations 107,578

Cardiac Surgical Operations 632

TRANSPLANT PROCEDURES

Bone Marrow Transplants 125

Cornea Transplants 269

Heart Transplants 13

Kidney Transplants 80

Liver Transplants 33

Lung Transplants 14

Pancreas Transplants 8

Total Transplant Procedures 542

TESTS

Electrocardiograms (EKG) 55,974

Echocardiograms (ECHO) 27,070

Electroencephalograms (EEG) 3,745

Electromyograms (EMG) 13,926

Laboratory Tests 5,175,675

Pulmonary Diagnostic Procedures 12,352

Radiographic Examinations and Treatments

Diagnostic Radiography 219,949

PET Scans 2,213

Head and Whole Body Scans 58,077

Magnetic Resonance Imaging 21,091

Nuclear Medicine 6,586

Total Radiographic Examinations and Treatments 307,916 SERVICES

Patient Transportation Services

Air and Mobile Critical Care Services 1,223

Helicopter Service 1,006

Mobile Ground Unit 217

Hospital Transportation 10,344

Total Patients Transported 12,790

Pharmacy Orders 2,314,000

Social Service Consultations 128,211

Units of Blood Products Transfused 29,319

Volunteer Service Hours 115,214

Meals Served 2,612,339

Pounds of Laundry Processed 5,187,140

HEALTH SCIENCES CAMPUSCHANGING MEDICINE. CHANGING LIVES. 85

Health Sciences Campus


Health SciencesCampusThe UI health sciences campus is composed of five health

colleges (dentistry, nursing, medicine, public health, and

pharmacy), University of Iowa Hospitals and Clinics, and the

Iowa City VA Health System all housed near each other on

the west side of the Iowa River. Together, they make up one

of the nation’s foremost academic health centers.

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1. Bowen Science Building (BSB)2. Carver Biomedical Research Facility (CBRB)3. Center for Disabilities and Development (CDD)4. College of Medicine Administration Building (CMAB)5. College of Public Health (PH)- Under Construction6. Dental Science Building (DSB)7. Eckstein Medical Research Building (EMRB)8. Field House (FH)9. Hardin Library (HL)10. Medical Education Building (MEB)11. Medical Education Research Facility (MERF)12. Medical Laboratories (ML)13. Medical Research Center (MRC)14. Nursing Building (NB)15. Pappajohn Biomedical Discovery Building (PBDB) Under Construction16. Pharmacy Building (PHARM)17. University of Iowa Hospitals & Clinics (UIHC)18. Veterans A�airs Medical Center (VA)19. Wendell Johnson Speech & Hearing Center (SHC)20. Westlawn (WL)21. Future UI Children’s Hospital

Parking Ramp

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8

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12

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10

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The University of Iowa Health Sciences Campus Map

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LEGEND

1. Bowen Science Building

2. Carver Biomedical Research Building

3. Center for Disabilities and Development

4. College of Medicine Administration Building

5. College of Public Health

6. Dental Sciences Building

7. Eckstein Medical Research Building

8. Field House

9. Hardin Library

10. Medical Education Building

11. Medical Education and Research Facility

12. Medical Laboratories

13. Medical Research Center

14. Nursing Building

15. Pappajohn Biomedical Discovery Building

16. Pharmacy Building

17. UI Hospitals and Clinics

18. VA Medical Center

19. Johnson Speech and Hearing Center

20. Westlawn


Health Sciences Policy Council

The Health Sciences Policy Council is comprised of deans of

the health sciences, the Executive Vice President and Provost,

Vice President for Medical Affairs, and other select members.

The Council meets monthly throughout the academic year and members share information of interest and potential consequences to the Health Sciences and the university.

In addition, the Council:

• Receives information and policy for action or potential awareness from other university officials

• Sets the annual agenda for joint activities

• Advises university officials on health sciences matters

• Promotes interdisciplinary collaboration

• Advocates for the health of Iowa citizens, and the university, and the health sciences


COLLEGE OF DENTISTRY

The University of Iowa dental department was one of 17 university dental programs in the country when established in 1882. As the dental profession evolved, the UI dental program grew into one of the nation’s best. Today the UI College of Dentistry is a key component of a major health sciences center, an essential resource to the state of Iowa, and an internationally recognized leader in dental education, research, and clinical care.

www.dentistry.uiowa.edu

COLLEGE OF NURSING

Renowned faculty, advanced clinical experiences, and a tradition of innovative leadership have led to the University of Iowa College of Nursing’s ranking as one of the best nursing programs in the nation. The college’s gerontological/geriatric and nursing service administration programs are ranked second in the nation by U.S. News & World Report. Graduates are sought after as highly skilled professionals who have received a rigorous education of the highest quality.

Established in 1898, the UI College of Nursing actively supports the recognition of nursing as a profession of leaders, scientists, and researchers.

www.nursing.uiowa.edu

COLLEGE OF PHARMACY

The University of Iowa College of Pharmacy offers the professional Doctor of Pharmacy (PharmD) degree and active MS and PhD graduate programs in pharmaceutics, medicinal and natural products chemistry, pharmaceutical socioeconomics, and clinical pharmaceutical sciences.

In addition to over 50 faculty members, 150 pharmacists from around the state and elsewhere serve as adjunct faculty, providing real-life learning experiences for pharmacy students. Pharmacy students also have on-site learning experiences at UI Hospitals and Clinics.

www.pharmacy.uiowa.edu

COLLEGE OF PUBLIC HEALTH

The UI College of Public Health was established in 1999. It is widely known for its dedication to academics, research, community service, and policy activities. Through these commitments, the College of Public Health helps students and society respond to new and emerging public health threats, as well as long-standing concerns, such as air and water quality, aging, health care quality and services, tobacco dependence, and substance abuse.

The College of Public Health offers a variety of programs and degrees within its five departments. There are also many combined-degree options between the College of Public Health and other colleges.

www.public-health.uiowa.edu


HARDIN LIBRARY FOR THE HEALTH SCIENCES

The Hardin Library for the Health Sciences serves the combined information and research needs of the Colleges of Dentistry, Medicine, Nursing, Pharmacy, Public Health, the UI Hospitals and Clinics, and the Department of Communication Sciences and Disorders.

The Hardin Library’s print collection contains more than 370,000 book and journal volumes. The Library’s collection includes more than 5,000 health sciences journals, most in electronic format; over 200 health sciences databases.

In addition to housing collections, the library has a large amount of space for research and study, with over 500 seats in a variety of formats, including four group studies and 16 individual studies.

www.lib.uiowa.edu/hardin

IOWA CITY VA HEALTH SYSTEM

Established in 1952, the Iowa City VA Health System is a 93-bed acute care facility that provides both primary and specialty care to approximately 184,000 veterans in 56 counties in eastern Iowa and western Illinois.

For decades the Iowa City VA Health System and the Carver College of Medicine have enjoyed a strong, nationally recognized partnership. The Iowa City VA Health System serves as a teaching platform for all Carver College of Medicine medical students and provides funding for 44 postgraduate residency and fellowship positions in internal medicine. The Iowa City VA Health System has consistently been in the top 10 in research among all VA Health Care Systems nationally.

www.iowacity.va.gov

Other Health Care Professionals on Campus

The UI Hospitals and Clinics also provides a training environment for other health care professionals.

A post-baccalaureate perfusion technology program has been on campus since 1992.

The program in radiation science offers training in radiologic technology, nuclear medicine technology, radiation therapy, as well as diagnostic medical and cardiac sonography.

A nationally accredited, full-time paramedic training program exists within the Department of Emergency Medicine and offers a variety of emergency medical services certifications.

A baccalaureate program in clinical laboratory sciences is available through a partnership with the University of Nebraska Medical Center.

The University of Iowa


The University of IowaFounded in 1847 as Iowa’s first public institution of higher

education, the University of Iowa (UI) has won international

recognition for achievements in the sciences, humanities,

and the arts.

The UI was the first public university in the United States to admit women and men on an equal basis and the first institution of higher education to accept creative work in theater, writing, music, and art as theses for advanced degrees. It established the first law school and the first educational radio station west of the Mississippi, broadcast the world’s first educational television programs, and developed and continues to hold preeminence in educational testing.

The Carver College of Medicine is one of 11 colleges at the University of Iowa.

The university both provides and attracts a wide variety of cultural opportunities, Big Ten athletic events, and a number of business endeavors resulting from scientific and educational research that originated at Iowa.

The University of Iowa is a major national research university with a solid liberal arts and sciences foundation. Respected for its excellence in education, passion for discovery, and tradition of public service, the university offers a close-knit intellectual community that draws students and scholars from around the world.

The crowd at a hawkeye football game.

THE UNIVERSITY OF IOWACHANGING MEDICINE. CHANGING LIVES. 93

StrengthsThe UI has world renowned research programs in genetics, hydraulics, and speech and hearing, and has recorded major innovations in agricultural medicine, biocatalysis, biomedical engineering, biomedical sciences, and pharmacology education. Its graduate programs in audiology, printmaking, creative writing, speech-language pathology, and nursing service administration are first-ranked. Iowa scientists,

including James Van Allen, have been pioneers in space research, designing and building research instruments for more than 50 successful U.S. satellites and space probes. The University of Iowa operates one of the nation’s most advanced and comprehensive university-owned teaching hospitals. It also has developed the most technically advanced driving simulator in the world.

Some NumbersMore than 30,500 students enroll at the UI each year. Some 55 percent come from Iowa, 25 percent from adjoining states, and 9 percent from the remaining states. International students from 100 countries make up 10 percent of the university’s enrollment. The faculty numbers about 1,700 and there are about 13,000 staff. The total annual operating budget is about $2.8 billion, and there are more than 120 major buildings, most of them within walking distance of one another.

Adding to the population are more than a million visitors each year who come to enjoy cultural events and art exhibits, to attend Big Ten athletic events, and to participate in the many conferences and educational programs scheduled at the university year-round.

Faculty include three Pulitzer Prize winners; five former U.S. Supreme Court clerks; two National Medal of Science recipients; 11 members of the American Academy of Arts and Sciences; 16 Institute of Medicine members; four members of the National Academy of Sciences; four Howard Hughes Medical Institute investigators; and members of other prestigious scholarly academies.

An aerial view of the Old Capitol and central campus.


Academic HighlightsWith more than four million volumes in its Main Library and nine specialty libraries, the UI collection ranks 18th among public research universities. Its 200,000 rare books and 500 historical manuscript collections include works by Walt Whitman, the Iowa Women’s Archives, and the Szathmary culinary arts collection.

The pioneering Iowa Writers’ Workshop is one of the most respected and competitive programs of its kind. The Workshop, the International Writing Program, and other initiatives make the UI a premier center for creative work in fiction, nonfiction, poetry, and drama.

Major interdisciplinary research centers at the University of Iowa include the Holden Comprehensive Cancer Center, the Carver Family Center for Macular Degeneration, the Cardiovascular Research Center, the Center for Bioinformatics and Computational Biology, and others.

The UI Alumni Association connects the university with its 227,000 alumni around the world.

After it was engulfed by flood waters in June 2008, the internationally acclaimed Hancher Auditorium, the university’s performing arts center, was forced to evacuate. Until it is rebuilt in a new location, Hancher is continuing to offer a range of works in venues throughout the area.

Also impacted by the flood, the Museum of Art’s 12,000 piece permanent collection is in storage until a new home is built. Its collection is ranked in the top 15 of public universities, and its Stanley Collection of African Art has been called one of the finest in the world.

The Department of Intercollegiate Athletics oversees 12 women’s and 10 men’s varsity squads and facilities including Kinnick Stadium and Carver-Hawkeye Arena.

THE UNIVERSITY OF IOWACHANGING MEDICINE. CHANGING LIVES. 95

Internal Audit, Board of Regents, State of Iowa

T. Stewart, Director

Office of the OmbudspersonS. Johnson/C. Joyce

Chief Diversity Officer*G. Dodge, Chief

Diversity Officer & Associate Vice President

Intercollegiate Athletics

G. Barta, Director

Chief of StaffM. Braun

Alumni Association

Center for Media Production

Hancher Auditorium

University Communications and Marketing

University Spokesperson

Coordinator, University Legal Services

Legal Advisor to President

Legal Risk Assessments

Liaison, Iowa Attorney General

Litigation Management

Regulatory

Compliance

UI Hospitals and Clinics


UI Physicians

UI Health Care

Spokesperson

Senior Vice Provost

Academic Oversight

CollegesBusinessDentistryEducationEngineeringGraduate CollegeLawLiberal Arts & SciencesMedicineNursingPharmacyPublic Health

Diversity

Faculty

Faculty Senate

Communications

Graduate and Professional Education

Health Sciences Policy Council

Other Academic Units

Undergraduate Education

Business Management

Controllership

Facilities Management

Operations Manual

Public Safety

Risk Management

Treasurer’s Office

University Secretary

Information Technology

Counseling Services

Parents Association

Recreational Services

Sexual Assault Response Coordinator

Student Disability Services

Student Government

Student Health Service

Student Judicial Procedures

University Housing

Iowa Memorial Union

Women’s Resource and Action Center

PresidentSally Mason, PhD


VP Research & Economic

DevelopmentD. Reed

VP Human ResourcesS. Buckley

VP Student LifeT. Rocklin

Senior VP & Treasurer

D. True

Executive VP & Provost

P.B. Butler

Central Research Facilities

Center for Biocatalysis and Bioprocessing

Conflict of Interest

Environmental Health & Safety

Human Subjects

Iowa Advanced Technology Labs

Iowa Centers for Enterprise

Multidisciplinary Centers

Natural History Museum

Oakdale Campus

Obermann Center for Advanced Studies

Office of Animal Resources

Old Capitol Museum

Public Policy Center

Research Integrity Officer

Research Info Systems

Sponsored Programs

Clinical Trials

State Archeologist

Hygienic Laboratory

Research Foundation

VP Strategic Communication

M. Brown

VP Legal Affairs & General Counsel

C. Reasoner

VP Medical Affairs

J. Robillard

Organization

The Iowa City Community


Iowa City CommunityThere’s a reason people relocate to the Iowa City area.

Picture a top-notch educational institution offering some of the nation’s best (and largest) health care facilities, a variety of art and theatrical attractions, an internationally renowned writers’ workshop, and research programs that are changing our world. Combine this with a welcoming community surrounded by the picturesque forests, lakes, and rivers of Eastern Iowa. It’s not hard to see why the Iowa City area is often ranked as one of the most livable communities in the nation.

In summertime, Iowa City sponsors weekly downtown jazz and pop concerts, and year-round major poets, writers, artists, historians, scientists, and others speak or perform at university or local venues.

Excellent public schools, safe and comfortable neighborhoods, and a highly educated population mean that Iowa City frequently appears high on “best-place-to-live” listings in national magazines.

The nearby countryside, scenic state parks, and the Iowa River provide many opportunities for walking, biking, and boating. Twenty miles to the north is Cedar Rapids, Iowa’s second-largest city, home to the Eastern Iowa Airport and a population of about 120,000. And Chicago, St. Louis, and Minneapolis/St. Paul are within easy driving distance.

LIFE IN IOWA CITYCHANGING MEDICINE. CHANGING LIVES. 99

Rankings and Recognition• World City of Literature U.N. Educational, Scientific and Cultural Organization

• No. 18 of Top 25 Green Cities in the U.S. Country Home

• No. 12 Small Metro Areas for Business & Careers Forbes

• No. 8 Up and Coming Tech Cities Forbes

• No. 18 Best Place in the Nation to Retire Money

• No. 4 Public Education Expansion Management

• Best Places to Live and Launch Fortune

• Best Town in the Midwest Outside Magazine

• 50 Best Places to Live and Play National Geographic Adventure Magazine

• Top 10 Most Affordable Places to Live & Work Sperling’s Best Places

• No. 5 Great Places to Live, Work MSN

Pomerantz Family Pavilion200 Hawkins DriveIowa City, IA 52242

Phone: (319) 356-4200Web: uihealthcare.org/cancer

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