scientific program-proteomics-aohupo beijing

6th Congress, Beijing, ChinaMay 5-7, 2012

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General Information

Welcome to the AOHUPO 6th Congress. All congress activities and exhibit booths are in the Convention Area of the China National Convention Center.

Registration and InformationThe registration desk is located on the 4th floor of the Convention Area (Entrance C1 of the CNCC).

Opening Time:May 4 08:30 - 21:00May 5 08:30 - 18:50May 6 08:30 - 17:40 May 7 08:30 - 18:20

Registered Delegates are Entitled to:Opening Ceremony, Welcome Reception/Banquet and Closing CeremonyAttendance to SessionsEntrance to ExhibitionAll Congress DocumentsCoffee BreaksForbidden City Tour

Name Badges and TicketsFor security purposes, delegates and exhibitors must wear their name badges at all times during the congress. Entrance to the meeting room will be limited to badge holders only. Tickets for social events and excursions will be issued to delegates who have booked for these events. Please present your tickets at these events and excursions.

AbstractsThe abstracts are available on a USB stick which is included in the registration package for registered delegates.

Program ChangesThe organisers cannot accept liability for any changes in the program due to external or unforeseen circumstances.

Oral PresentationsOnly LCD computer projectors are used for oral sessions. The congress session computers are running Windows XP and PowerPoint 2007. Speakers must go to the Speaker Ready Room at least one day prior to their talks to load their powerpoints onto the congress computers. The Speaker Ready Room is Room 409, 4th Floor. The room will keep opening with a technician present during the following time slots:May 4 14:30 - 17:30May 5 08:30 - 18:50May 6 08:30 - 17:40May 7 08:30 - 12:10

Poster PresentationsRefer to the poster numbers in this program for board assignments. Authors are expected to supply scotch tape to mount

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their posters. Posters must be in place by 16:30 on May 5 at the Poster Area and removed at 17:40 on May 7. To assure all attendees to have time for viewing posters, please do not remove posters ahead of the designed time. All the posters have the opportunities to join the competition of the AOHUPO 2012 Excellent Poster Award. 30 posters will be awarded in the Closing Ceremony. Each award will equal RMB 500. Poster presentation time:May 6 12:10 - 14:00 May 7 12:10 - 14:00

Duplication, RecordingWithout permission from authors, taking photographs, audio-taping, video-recording, digital taping and any other form of duplication are strictly prohibited in the session rooms and poster areas.

Mobile PhonesParticipants are kindly requested to turn off their cell phones or keep the cell phones in vibration state when entering the congress rooms and in the poster area.

Smoking PolicyIn the China National Convention Center, smoking is prohibited. Smoking is only permitted in a few designated areas outside the building.

Internet AccessA free Internet room will be opened during the congress hours in the Plenary Hall A-Po.

CateringSome specified meal tickets are included in the registration package for registered delegates. Please refer to the table below for the location and times. Please note that our generous sponsors will also provide meals at the Industry Workshops on May 6-7 with pre-assignment at their booths.

May 5 May 6 May 7

Lunch At delegates’ own expense

Exhibition Hall 6, B1 Floor Exhibition Hall 5, B1 Floor 12:10 - 13:30 12:10 - 13:30

Dinner

Ballroom A, 1st Floor Nine Dynasty Restaurant At delegates’ own expense

19:00 - 21:00 17:40 - 20:00 (Invited)

L4 Lobby, 4th Floor L4 Lobby, 4th Floor Coffee Break --- 09:50 - 10:10 09:50 - 10:10 16:00 - 16:20 16:00 - 16:20

STAFF BrigadeA team of enthusiastic students will be at your service. During the congress hours, they will provide hospitality support and steward services. They will also serve in most of the meeting rooms as technical assistants and can be easily recognized by their shirts of STAFF.

TimeBeijing is 8 hours ahead of Greenwich Mean Time.

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Weather May is the best month for weather condition in Beijing. Typically, it is neither hot nor cold – just the perfect time to stay and visit in Beijing and elsewhere in China. The average temperature in Beijing in May is 20℃.The average highest temperature is 25℃and the average lowest temperature is 17℃.

Water It is not recommended to directly drink the water from the tap in your hotel room or at the congress area. If you want to drink cold water, it is best to order or buy bottled water, mineral or distilled water. Hotels generally provide an electrically heated kettle to boil water from the tap in your room. Some hotels also provide a special tap in the lavatory that delivers a flow of purified water for drinking.This advice also applies to your pre-congress or post-congress travel in other cities in China.

Voltage, Socket and PlugsThe electrical current in China is 220-volts, 50HzA/C. Hotels generally provide wall sockets in every room, accommodating both the standard “Flat blade attachment plug (Type A)”and common “Oblique flat blades with ground(inverted V) plug (Type I)”as well as the not-so-common “Round pin attachment plug (Type C)”as shown in following photographs.

CurrencyThe local currency is the RMB. Visa and MasterCard are accepted at the Registration Desk. Foreign currency will not be accepted. You are requested to pay with cash in RMB or credit card. The amount debited from your account will vary due to fluctuations in the exchange rate. There is normally a 4% additional bank charge. Participants can exchange their currencies at airports, major hotels and banks in China. The exchange rate will be given daily by the Bank of China. Currently, 1USD can be exchanged for about 6.3 RMB yuan. All currency exchange receipts should be saved in case participants want to exchange RMB back to their own currency. Banks may demand to see the original exchange receipt.

EmergenciesIf you or any other delegate is unwell, an accident or any other emergency occurs, while at the China National Convention Center, please contact the Registration Desk or any staff member.

Lost PropertyIf you see any unattended parcel, please report to one of the congress staff members. If you lose anything at the China National Convention Center, please enquire at the Registration Desk.

InsuranceThe congress organisers recommend participants to posses travel, property medical or other necessary insurances before coming to China. The 6th AOHUPO Congress Organisers cannot be held responsible for the costs resulting from personal accidents or property loss during the congress.

Wall socket Type A plug Type I plug Type C plug

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HotlinesPhone number110 Police114 Local Telephone Number Inquiry117 Time Inquiry119 Fire120 Ambulance121 Weather Forecast122 Traffic Police

How to Reach the China National Convention CenterAddress: No.7 Tianchen East Road, Chaoyang District, Beijing China

Subway line 8 Olympic Green direct entrance CNCC (Exit A、D、E), about 26km to Beijing Capital International Airport, 25 minutes.

Bus: 328、484、628、630、419、913、379 get off at Walinankou Station.

A) Beijing Railway Station - China National Convention Center

Subway line 2: Beijing Station-Yonghegong Lama Temple Stat ion, t ransfer l ine 5 to Huixinxijie Nankou Station, transfer line 10 to Beitucheng Station, finally transfer line 8 to Olympic Green Station.

B) Beijing West Railway Station - China National Convention Center

Subway line 1: Military Museum-Fuxinmen Station, transfer line 2 to Yonghegong Lama Temple Station, transfer line 5 to Huixinxijie Nankou Station, transfer line 10 to Beitucheng Station, finally transfer line 8 to Olympic Green Station.

C) Beijing South Railway Station - China National Convention Center

Subway line 4: Fuxinmen Station, transfer line 10 to Beitucheng Station, finally transfer line 8 to Olympic Green Station.

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Please take me to the China National Convention Center Grand Hotel

Please take me to the InterContinental Beijing Beichen

Please take me to the China National Convention Center

Place Card

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Congress Agenda

Time Program Venue

May 4, 2012 08:30-21:00 Registration L4 Olympic Green Foyer

08:30-17:20 International Interactome Initiative (I3) Workshop Room 401

May 5, 2012 08:00-09:50 2nd AOHUPO hESC-MPI Workshop Room 401

08:30-16:30 Registration L4 Olympic Green Foyer

09:15-16:15 5th C-HPP Consortium Workshop Room 402AB

10:00-16:15 Education & Training Workshop Room 301AB

16:30-17:00 Opening Ceremony

17:00-18:20 Plenary Lecture Plenary Hall A

18:20-18:50 10th Anniversary for CNHUPO & Release of Special Book “Liver Proteome”

19:00-21:00 Welcome Reception/Banquet Ballroom A

May 6, 2012 08:30-09:50 Plenary Lecture Plenary Hall A

09:50-10:10 Coffee Break L4 Lobby


Industrial Workshop: ThermoFisher Auditorium

The Impact of High-Performance Mass Spectrometry in Biology Research

12:10-14:00

Posters Plenary Hall A-Po

Exhibitions L4 Lobby

12:30-13:30 AOHUPO Council Meeting Room 401

Parallel Sessions

Session 1: Advancement of Biomarkers Research for Disease and Drugs Plenary Hall A

14:00-16:00 Session 2: Biomarkers of Disease and Personalized Medicine Auditorium

Session 3: Proteomics of Model Organisms and Other Plants & Microorganisms Room 402AB

Session 4: Chemical Proteomics and Drug Discovery Room 301AB



17:40-20:00 Expert Hospitality Dinner (INVITED ONLY) Nine Dynasty Restaurant

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Time Program Venue

May 7, 2012 08:30-09:50 Plenary Lecture Plenary Hall A


Parallel Sessions

10:10-12:10

Session 5: Post-translational Modifications Plenary Hall A

Session 6: Glycoproteins and Glycans: Structure, Function and Applications Auditorium

Session 7: Proteomics and Clinical Application Room 402AB

Industrial Workshop: AB SCIEX Auditorum

Pushing the Limits in Proteomics Workflows

12:10-14:00

Posters Plenary Hall A-Po

Exhibitions L4 Lobby

Parallel Sessions

14:00-16:00 Session 8: Quantitative and Targeted Proteomics and System Biology Plenary Hall A

Session 9: Proteomics: New Approaches and Novel Techniques Auditorium

14:00-16:05

Session 10: Bioinformatics: Databases, Post-translation Modifications, Room 402AB

Quantification and Validation



17:40-18:10 Closing Ceremony

May 8, 2012

08:30-12:10 Tour Forbidden City

Congress Agenda

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Plenary Lecture Program

Time Speaker and Title

May 5, 2012Chair: Fuchu He, Beijing Proteome Research Center; Beijing Institute of Radiation Medicine, China

17:00-17:40 Aaron Ciechanover

Faculty of Medicine, Technion-Israel Institute of Technology, Israel

Title: Why Our Proteins Have to Die so We shall Live or the Ubiquitin Proteolytic System - From

Basic Mechanisms thru Human Diseases and onto Drug Development

17:40-18:20 Xiaodong Wang

National Institute of Biological Sciences, China

Title: Understanding Cell Death

May 6, 2012

Chair: Kazuyuki Nakamura, Yamaguchi University Graduate School of Medicine, Japan

08:30-09:10 Daniel W. Chan

Johns Hopkins Medical Institutions, USA

Title: Translating Proteomics into the Clinical Laboratory: The Future Is Now

09:10-09:50 Kunliang Guan

Fudan University, China; University of California, San Diego, USA

Title: Protein Lysine Acetylation in Metabolism Regulation

Chair: Yukui Zhang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China

10:10-10:50 Leroy Hood

Institute for Systems Biology, USA

Title: Systems Biology, Transformational Technologies and the Emergence of Proactive P4 Medicine

10:50-11:30 Ruedi Aebersold

ETH Zurich and University of Zurich, Switzerland

Title: Mass Spectrometry Based Proteomics and Systems Biology

11:30-12:10 Pierre Legrain

Ecole Polytechnique, France

Title: From Genes and Proteins to Human Being: Can We Revisit the Role of Heredity?

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Time Speaker and Title

May 6, 2012

Chair: Richard J. Simpson, La Trobe University, Australia

16:20-17:00 Gilbert S. Omenn

University of Michigan, USA

Title: Role of the HUPO Human Proteome Project in Advancing the Field of Proteomics

17:00-17:40 Young-Ki Paik

Yonsei Proteome Research Center, Korea

Title: A Chromosome-Centric Human Proteome Project to Characterize the Sets of Proteins

Encoded in the Genome

May 7, 2012Chair: Zihe Rao, Tsinghua University, China

08:30-09:10 Tom L. Blundell

University of Cambridge, UK

Title: The Structural Proteome and Drug Discovery: Chemical Tools for Targeting Protein Networks

09:10-09:50 John R. Yates

The Scripps Research Institute, USA

Title: Protein Quantitation Using Stable Isotope Labeling in Mammals

Chair: Young-Ki Paik, Yonsei Proteome Research Center, Korea

16:20-17:00 Guangbiao Zhou

Institute of Zoology, Chinese Academy of Sciences, China

Zhu Chen

Shanghai Jiao Tong University School of Medicine; Minister of Health, China

Title: Synergistic Targeting Therapies against Oncoproteins for Acute Myeloid Leukemia

17:00-17:40 Denis Hochstrasser

Geneva University Hospital, Switzerland

Title: Clinical Mass Spectrometry & Proteomics

Plenary Lecture Program

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Parallel Session Programs

14:00-16:00, May 6, 2012Plenary Hall A

Session 1: Advancement of Biomarkers Research for Disease and DrugsChairs: Maxey C.M. Chung & Terence C.W. Poon

Time Speaker and Title14:00-14:20 Maxey C.M. Chung

National University of Singapore, Singapore

Title: Mining the Gastric Fluid and Gastric Secretome for Potential Diagnostic Markers for the

Detection of Early Gastric Cancer

14:20-14:40 György Marko-Varga

Lund University, Sweden

Title: Biomarker Diagnostics Developments for Targeted Drug Treatments

14:40-15:00 Terence C.W. Poon

The Chinese University of Hong Kong, Hong Kong SAR, China

Title: Serum N-Glycomic Fingerprint for the Diagnosis of Liver Fibrosis and Liver Cirrhosis in

Patients with Chronic Hepatitis B Infection before and after Antiviral Treatment

15:00-15:20 Siqi Liu

Beijing Institute of Genomics, Chinese Academy of Sciences, China

Title: The Cascade Changes of Functional Molecules in Gastric Cancer Cells: Mutation Linkage of

Genomics and Proteomics

15:20-15:40 Chan-Wha Kim

Korea University, Korea

Title: Transgelin Promotes Migration and Invasion of Cancer Stem Cells

15:40-16:00 Canhua Huang

West China Hospital, Sichuan University, China

Title: Proteomic Annotation of the Metabolic and Oxidative Stresses in Tumor Initiation and

Progression

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14:00-16:00, May 6, 2012Auditorium

Session 2: Biomarkers of Disease and Personalized MedicineChairs: Mark Baker & Jisnuson Svasti

Time Speaker and Title14:00-14:20 Mark Baker

Macquarie University, Australia

Title: Membrane Proteomics: Peeking into the Pandora’s Box of Cancer Metastasis

14:20-14:40 Xuemin Zhang

National Center of Biomedical Analysis, China

Title: The Mechanistic Linkage between Inflammation and Tumorigenesis

14:40-15:00 Kazuyuki Nakamura

Yamaguchi University Graduate School of Medicine, Japan

Title: Disease Biomarker Discovery: HSP27 for Diagnostics and Therapeutics of Pancreatic Cancer

15:00-15:20 Dacheng He

Beijing Normal University, China

Title: Chronological Protein Expression in Liver Regeneration

15:20-15:40 Guangyan Cai

Chinese PLA General Hospital, China

Title: Characterization of Glomerular Diseases Using Proteomic Analysis Methods

15:40-16:00 Xianchun Wang

Hunan Normal University, China

Title: Identification and Validation of Rab3A as a New Interacting Partner of Synaptotagmin I:

Implications in the Regulation of Synaptic Vesicle Exocytosis

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14:00-16:00, May 6, 2012 Room 402AB

Session 3: Proteomics of Model Organisms and Other Plants & MicroorganismsChairs: Ravi Sirdeshmukh & Ghasem Hosseini Salekdeh

Time Speaker and Title14:00-14:20 Ghasem Hosseini Salekdeh

Royan Institute for Stem Cell Biology and Technology, Iran

Title: Quantitative Proteome and Transcriptome Analysis of Human Embryonic Stem Cells

Differentiation to Neural Cells

14:20-14:40 Yhong-Hee Shim

Konkuk University, Korea

Title: Proteomic Analysis of Sperm Proteins Controlled by IFE-1, A germline-specific Isoform of

eIF4E, in C. elegans

14:40-15:00 Xuanxian Peng

Yat-sen Sun University, China

Title: Proteomics Mechanisms of Bacterial Antibiotic Resistances

15:00-15:20 Vengatesen Thiyagarajan

The University of Hong Kong, Hong Kong SAR, China

Title: Marine Environmental Proteomics and Its Applications for Climate Change

15:20-15:40 Jahanbakhsh-Godehkahriz

University of MohagheghArdabili, Iran

Title: Proteomic Analysis of Porphobilinogen (PBG) Deaminase& 3-oxoacyl-[acyl-carrier-protein]

Synthase I (KAS I) in Cheyenne Winter Wheat under Prolonged Low temperature

15:40-16:00 Yingchun Wang

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, China

Title: Proteomic Identification of Slr0110-regulated Proteins that are Necessary for Heterotrophic

Growth of Synechocystis sp. PCC6803

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14:00-16:00, May 6, 2012Room 301AB

Session 4: Chemical Proteomics and Drug DiscoveryChairs: Ho Jeong Kwon & Qingyu He

Time Speaker and Title14:00-14:25 Guoqiang Chen

Shanghai Jiao Tong University School of Medicine, China

Title: Natural Product Adenanthin Specifically Targets Peroxiredoxin I/II for Its Anti-leukemic

Activities

14:25-14:50 Ho Jeong Kwon

Yonsei University, Korea

Title: Chemical Proteomics Based Target Identification of a Natural Anti-angiogenic Small Molecule

14:50-15:15 Qingyu He

College of Life Science and Technology, Jinan University, China

Title: Mitochondria Are a Major Target of the Anti-Cancer Agents Derived from Traditional

Chinese Medicine (TCM)

15:15-15:30 Lixin Zhang

Institute of Microbiology, Chinese Academy of Sciences, China

Title: Bioprospecting Natural Products for Potential Anti-Infective Drugs

15:30-15:45 Lianghai Hu

College of Life Science, Jilin University, China

Title: Chemical Proteomics-based Approach for Drug Target Discovery in Living Systems

15:45-16:00 Fuyi Wang

Institute of Chemistry, Chinese Academy of Sciences, China

Title: Organometallic Ruthenium Complexes Inhibit the Enzymatic Activity of Protein Tyrosine

Phosphatase 1B via Coordination to and Subsequently Induced Oxidation of the Active Thiols

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Session 5: Post-translational ModificationsChairs: Hisashi Hirano & Jun Qin

Time Speaker and Title10:10-10:30 Hisashi Hirano

Yokohama City University, Japan

Title: Functional Analysis of Co- and Post-translational Modifications in Large Protein Complexes

10:30-10:50 Jun Qin

Beijing Proteome Research Center, China

Title: Building a Proteomics Research Facility in China

10:50-11:10 Peipei Ping

University of California at Los Angeles, USA

Title: PTM Analyses of Functional Proteomes: Linking Molecular Modifications to Cardiac

Phenotypes

11:10-11:30 Jiarui Wu

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

Title: Molecular Bases for Population Variation: from SNP to SAP

11:30-11:50 Yu-Ju Chen

Institute of Chemistry, Academia Sinica, Chinese Taipei

Title: A Simple Label-free Strategy towards Comprehensive Tissue Membrane Proteomics and

Post-translational Modificome

11:50-12:10 Shimin Zhao

Fudan University, China

Title: Meatbolites Regulate Epigenetics and Signaling

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10:10-12:10, May 7, 2012Auditorium

Session 6: Glycoproteins and Glycans: Structure, Function and ApplicationsChairs: Hisashi Narimatsu & Haojie Lu

Time Speaker and Title10:10-10:30 Hisashi Narimatsu

Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and

Technology, Japan

Title: Large-scale Identification of N-glycosylated Proteins of Mouse Tissues and Construction

of a Glycoprotein Database, GlycoProtDB

10:30-10:50 Hyun Joo An

ChungNam National University, Korea

Title: Human Cell Surface Glycan Mapping Using Mass Spectrometry

10:50-11:10 Kay-Hooi Khoo

Institute of Biological Chemistry, Academia Sinica, Chinese Taipei

Title: Technical Developments towards Realizing Shotgun Glycoproteomics for Protein Site-specific

Glycosylation Mapping

11:10-11:30 Yinkun Liu

Fudan University, China

Title: Glyco-biomarker Screening and Further Application in Hepatopathy

11:30-11:50 Wonryeon Cho

Wonkwang University, Korea

Title: Targeted Glycoproteomics for Cancer Biomarker Discovery

11:50-12:10 Wan Huang

The Fourth Military Medical University, China

Title: Modulation of the CD147-Induced Matrix Metalloproteinases Activity: The Role of CD147

N-Glycosylation

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10:10-12:10, May 7, 2012Room 402AB

Session 7: Proteomics and Clinical ApplicationChairs: William S. Hancock & Zhinan Chen

Time Speaker and Title10:10-10:35 William S. Hancock

Northeastern University, USA

Title: Chromosome 17 as Part of the C-HPP Initiative and the Study of Oncogene (ERBB2 and EGFR)

Driven Cancer

10:35-11:00 Zhinan Chen

The Fourth Military Medical University, China

Title: Biosignatures Network and Its Novel Target Drugs

11:00-11:25 Nikhat Ahmed Siddiqui

University of Karachi, Pakistan

Title: Alzheimer’s Disease Proteomics---at the Crossroads between Promises and Problems

11:25-11:40 Tadashi Kondo

National Cancer Center Research Institute, Japan

Title: Proteomics for Biomarker Development to Personalized Medicine

11:40-11:55 Archakov Alexander

Russian Academy of Medical Sciences, Russia

Title: Three Bottlenecks in Proteomics

11:55-12:10 Jau-Song Yu

Chang Gung University, Chinese Taipei

Title: Multiplexed Quantification of 63 Proteins in Human Urine by Multiple Reaction Monitoring-

based Mass Spectrometry for Discovery of Potential Bladder Cancer Biomarkers

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Session 8: Quantitative and Targeted Proteomics and System BiologyChairs: Visith Thongboonkerd & Xiaohong Qian

Time Speaker and Title14:00-14:20 Catherine Costello

Boston University School of Medicine, USA

Title: Determination of Differential Phosphorylation and Biological Responses to EGF and Nucleotides

14:20-14:40 Xiaohong Qian

Beijing Proteome Research Center; Beijing Institute of Radiation Medicine, China

Title: Biological Mass Spectrometry Based Strategies for Qualitative and Quantitative Analysis of

Core Fucosylated Glycoproteins

14:40-15:00 Visith Thongboonkerd

Mahidol University, Thailand

Title: Applications of Proteomics to Kidney Stone Disease

15:00-15:20 Hanfa Zou

Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China

Title: Method Development for Qualitative and Quantitative Phosphoproteome

15:20-15:40 Peng Xie

Chongqing Medical University, China

Title: The Proteomics and Metabonomics Research of Major Depressive Disorder

15:40-16:00 Jianke Li

Chinese Academy of Agricultural Sciences, China

Title: Comparative Analysis of Nuclear Proteomes between Honeybee (Apis Mellifera L.) Queen and

Worker Larvae

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14:00-16:00, May 7, 2012Auditorium

Session 9: Proteomics: New Approaches and Novel TechniquesChairs: Bill Jordan & Ajay Kohli

Time Speaker and Title14:00-14:20 Bill Jordan

Victoria University of Wellington, New Zealand

Title: Membrane Proteomes: Analysis and Metabolic Functions

14:20-14:40 Richard J. Simpson

La Trobe University, Australia

Title: Purification and Characterisation of Two Discrete Exosome Populations from the Human

Colon Cancer LIM1863 Cell Line

14:40-15:00 Yukui Zhang

Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China

Title: Novel Materials, Methods and Platforms for Separation, Identification and Quantitation of

Proteomes

15:00-15:20 Eugene N. Nikolaev

Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Russia

Title: The New Possibilities of FT ICR in Very High Resolution Mass Spectrometry of Peptides and

Proteins. Fine Structure of Peptides Mass Spectra and Isotopic Resolution of Near 200kDa Proteins

15:20-15:40 Mengqiu Dong

National Institute of Biological Sciences, China

Title: An Integrated High-throughput Workflow for Identification of Crosslinked Peptides from

Complex Samples

15:40-16:00 Rao V. L. Papineni

Carestream Health, Inc., USA

Title: Non Invasive Functional Molecular Imaging-Illuminate the Myeloperoxidase Enzyme Activity

During Ovarian Cancer Mouse Model Tumorigenesis

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14:00-16:05, May 7, 2012Room 402AB

Session 10: Bioinformatics: Databases, Post-translation Modifications, Quantification and Validation

Chairs: Pierre-Alain Binz & Weimin Zhu

Time Speaker and Title14:00-14:25 Pierre-Alain Binz

Swiss Institute of Bioinformatics, Switzerland

Title: Believe in Proteomics Results: On the Need for Data and Information Sharing

14:25-14:50 Weimin Zhu

Taicang Institute of Life Science Information, China

Title: Stories of Peptide/Protein Sequences – Protein Annotations

14:50-15:05 Lisitsa Andrey

Institute of Biomedical Chemistry, Russia

Title: Knowledgebase for Single Chromosome Proteins

15:05-15:20 Hongwei Xie

National University of Defense Technology, China

Title: Share the ppb Level Accuracy in Common LC-MS Analysis

15:20-15:35 Juan Pablo Albar

National Center for Biotechnology – CSIC, Spain

Title: Automatic Reporting and Reproducibility Analysis Using the ProteoRed “MIAPE extractor” Tool

15:35-15:50 Dong Li

Beijing Proteome Research Center, China

Title: Bioinformatics for Interactomics: Knowledge Mining from Large-scale Protein-protein

Interaction Networks

15:50-16:05 Will Dracup

Nonlinear Dynamics Ltd., UK

Title: A Radical New Approach to Proteomic Experiment Design and Execution that Maximises the

Likelihood of Clinical Impact

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Workshop Programs

International Interactome Initiative (I3) Workshop

Time: 08:30-17:20, May 4, 2012

Venue: Room 401, China National Convention Center

Chairs: Benoit Coulombe, Xiaoming Yang and Jun Qin

Schedule:

08:30-08:35 Greetings from the Local Host: Jun Qin, BPRC, China

08:35-08:45 Introduction to International Interactome Initiative (I3) on Cardiometabolic Diseases Benoit Coulombe, Institut de Recherches Cliniques de Montréal, Canada

Part 1 Chair: Benoit Coulombe08:45-09:10 Mapping and Systematic Monitoring of the Protein Interactome Underlying Cardiometabolic Diseases to Accelerate Biomarker Discovery and Personalized Drug Treatment —Global introduction and experimental approach to interactome mapping Benoit Coulombe, Institut de Recherches Cliniques de Montréal, Canada

09:10-09:35 Bioinformatics and Computational Analysis of Protein Interaction Data Mathieu Blanchette, McGill University, Canada

09:35-10:00 Mass Spectrometry-SRM of Biomarkers in Clinical Samples Denis Faubert, Institut de Recherches Cliniques de Montréal, Canada

10:00-10:25 Clinical Aspects of Biomarker Discovery in Type 2 Diabetes Marie-Soleil Gauthier, Institut de Recherches Cliniques de Montréal, Canada

10:25-10:35 Coffee Break

Part 2 Chair: Xiaoming Yang10:35-11:00 Analysis of Mammalian Endogenous Complexome Jun Qin, Beijing Proteome Research Center, China

11:00-11:25 Protein-protein Interactions between Host and Yersinia pestis Ruifu Yang, Beijing Institute of Microbiology and Epidemiology, China

11:25-11:50 Study on Mitochondrial Intermembrane Space Protein Network Miao Yu, Beijing Institute of Radiation Medicine, China

11:50-13:00 Lunch and Rest

13:00-13:25 Transcription Factor Interactome Network in Human Hematopoietic Stem Cell Changyan Li, Beijing Institute of Radiation Medicine, China

13:25-13:50 Functional Research of Human Liver Protein-protein Interaction Network Jian Wang, Beijing Proteome Research Center, China

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Part 3 Chair: Jun Qin13:50-14:15 Protein Interactome Analysis Reveals HIP-55/14-3-3 Complex as a Potential Regulator of Tumorigenesis in Non-small Cell Lung Cancer Zijian Li, Peking University Third Hospital, China

14:15-14:40 MeCP2 Is Regulated by Phosphorylation and Does Not Stably Associate with SWI/SNF Chromatin- Remodeling Complex Keping Hu, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, China

14:40-15:05 A Novel Histone H4 Binding Activity and Transcriptional Regulatory Function for Signal Recognition Particle Subunits SRP68 and SRP72 Jiemin Weng, East China Normal University, China

15:05-15:30 Protein Phosphorylation and Regulatory Swith Yixue Li, Shanghai Information Center for Life Science, CAS, China

15:30-15:55 Bioinformatics for I3: Construction, Data Management and Knowledge Mmining for the Large-scale Protein- protein Interaction Datasets Dong Li, Beijing Proteome Research Center, China

15:55-16:20 High-Performance Mass Spectrometry as a Tool for Modular Cell Biology Andreas FR Huhmer, Thermo Fisher Scientific


16:35-17:20 Discussion and Future Plan Chairs: Benoit Coulombe, Xiaoming Yang and Jun Qin

18:00-20:00 Dinner and Further Discussion (INVITED ONLY)

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2nd AOHUPO hESC-MPI Workshop(AOHUPO human Embryonic Stem Cell-Membrane Proteome Initiative)

Time: 08:00-09:50, May 5, 2012

Venue: Room 401, China National Convention Center

Chairs: Ghasem Hosseini Salekdeh, Yu-Ju Chen

Host: Ying Jiang

Theme: Current Status and Future Direction of AOHUPO hESC-MPI

Schedule: 08:00-08:05 Greetings from the Local Host Ying Jiang, Beijing Proteome Research Center, China

08:05-08:15 Brief Summary of the Multi-lab Data for the AOHUPO MPI Bill Jordan, Chair of AOHUPO MPI, Victoria University of Wellington, New Zealand

08:15-08:30 Proteomics of Undifferentiated & Neuronally-differentiating Huntington Disease hESCs Mark Baker, Macquarie University, Australia

08:30-08:40 Sample Preperation for Plasma Membrane Proteome Analysis by Mass Spectrometry Songping Liang, Hunan Normal University, China

08:40-08:50 An Overview of AOHUPO hESC-MPI Ghasem Hosseini Salekdeh, AOHUPO hESC-MPI, Royan Institute for Stem Cell Biology and Technology, Iran

08:50-09:05 AOHUPO hESC MPI Sample Preparation Yu-Ju Chen, Co-chair of AOHUPO hESC-MPI, Academia Sinica, Chinese Taipei

09:05-09:15 Proteomic Analysis on AOHUPO hESC MPI Sample Ying Jiang, Beijing Proteome Research Center, China

09:15-09:25 Brief Summary Report of Mitochondria Sample Run Maxey C.M. Chung, National University of Singapore, Singapore

09:25-09:35 Integration of AOHUPO hESC MPI data Yu-Ju Chen, Co-chair of AOHUPO hESC-MPI, Academia Sinica, Chinese Taipei

09:35-09:50 Discussion

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5th C-HPP Consortium Workshop(The Chromosome-Centric Human Proteome Project)

Time: 09:15-16:15, May 5, 2012Venue: Room 402AB, China National Convention CenterChairs: Young-Ki Paik, William S. Hancock and György Marko-VargaHost: Fuchu HeTheme: Setting out the Standard Guidelines and the Milestones for the C-HPPGoals: Completion of the Organisation and Working Formats for the C-HPP

Schedule:09:15-09:20 Greetings from the Local Host: Fuchu He, BPRC, China

09:20-09:35 Strategic Directions for the C-HPP as Part of the Overall Human Proteome Project (HPP) Gil Omenn, Chair of HPP Consortium, University of Michigan, USA

09:35-09:45 Update on the Progress of the C-HPP Consortium Young-Ki Paik, Chair of C-HPP Consortium, YPRC, Korea

09:45-10:15 Genetic Variants from Next Generation, Whole Genome DNA Sequencing Datasets: A 1000 Genomes Perspective Charles Lee, Co-Chair of 1000 Genome Project, Harvard Medical School, USA

10:15-11:45 Key Issues on the Execution of the C-HPP Guidelines (e.g., Bioinformatics) Co-Chaired by William S. Hancock, Gil Omenn and Pierre Legrain

● Consensus on the governance and completion of the structure (Committees, WG etc.) ● Data Management (to address the questions how the data generated in the specific chromosome projects will be transferred to the three pillar databases, what quality criteria should be applied etc.) -see also C-HPP guideline paper (Paik et al., 2012, JPR, 11(4):2005-13) ● General Experimental Procedures ● Resources: Abs and Reagents (Eduardo Nice and more) ● Bioinformatics and Web Portal (Seul-Ki Jeong, Robert J. A. Goode,, more)

● Coordination with B/D-HPP, HPP Resource Pillars, and Other HUPO Initiatives (HAI, PSI etc)

11:45-13:45 Luncheon Symposium

11:45-13:45 Progress Report on Each Chromosome Team

Part I: Chair, György Marko-Varga, Co-Chair of C-HPP Consortium, Sweden

Chr 1 (China) CAPE (Chromosome-Assembled Proteome Encyclopedia) and Its Highlight with Chromosomes 1 and 8 Fuchu He, BPRC, China

Chr 2 (Switzerland) Pierre-Alain Binz, SIB, Switzerland

Chr 3 (Japan) Chromome 3 and the Disease-Related Proteins Discovered Using Laser-Microdissected (LMD) Lung- Carcinoma FFPE tissues

Toshihide Nishimura/Hiromasa Tojo/Kazuyuki Nakamura, Tokyo Medical University, Japan

Chr 7 (ANZ) Down Under Chromosome 7 Mark Baker, Macquarie University, Australia and Bill Jordan, Victoria University of Wellington, New Zealand

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Part II: Chair, Pierre Legrain, Ecole Polytechnique, France

Chr 11 (Korea) Human Proteome Project for Chromosome 11 in Human Brain Tissue Jong Shin Yoo, KBSI, Korea

Chr 12 (Thailand) Introduction of Chromosome 12 Initiative Visith Thongboonkerd, Mahidol University, Thailand

Chr 13 (Korea) Progress on Chr 13 HPP Young-Ki Paik, YPRC, Korea

Chr 16 (Spain) Spanish HPP Consortium: Current Developments on the Characterization of the Proteins Encoded by the Chromosome 16

Juan Pablo Albar, Madrid, Spain

Chr 17 (USA) Progress on Chr 17 HPP William S. Hancock, Northeastern University, USA

Part III: Chair, Fuchu He, BPRC, China

Chr-18 (Russia) Proteome of 18th Chromosome in Plasma, Liver and HepG2 Cells Investigated by SRM/MRMs Alexander Archakov, RAMS, Russia

Chr-19 (Sweden) Progress Report from Chromosome 19 György Marko-Varga, Lund University, Sweden

Chr-X (Japan) Japan Chromosome X Project (JCXP) Consortium: To Do and Done Tadashi Yamamoto, Niigata University, Japan

Chr-Y (Iran) Human Y Chromosome Proteome Project: A Genomics and Proteomics Perspective Ghasem Hosseini Salekdeh, Royan Institute for Stem Cell Biology and Technology, Iran

(Only three teams of Chr 6, 14, 21 will be missing from this workshop)


14:05-14:45 Funding issues: by György Marko-Varga and Pierre Legrain Grant Situation (any granting agency for C-HPP)

14:45-15:55 Progress Reports and Publications: by William S. Hancock and Young-Ki Paik ● Progress Report Forms (standard form) (To be distributed later) ● Special Issue Publication: Jan 2013 Issue of JPR ● General guidelines for manuscript preparation and submission ● Deadline of Submission: September 30, 2012

15:55-16:15 Upcoming Boston Congress and Strategy for Session Organisation Gil Omenn, Young-Ki Paik and William S. Hancock

* Remarks: This meeting also functions as the 1st Principal Investigator Council (PIC) meeting of the C-HPP Consortium unless otherwise noted. Any decisions on the major policies and governance on the C-HPP made from this meeting would be recorded as the PIC’s decisions.

Inquiry: For Logistics and Travel Arrangement, Contact: Ping Xu, [email protected] For Programs and Presentations, Contact: Young-Ki Paik, [email protected] * This program is subject to change without notice.

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Proteomics-Its Principles and ApplicationsEducation & Training Workshop

Time: 10:00-16:15, May 5, 2012Venue: Room 301AB, China National Convention Center

Chairs: Kazuyuki Nakamura, Richard Simpson

Schedule: 10:00-10:15 Introduction to IPTP Kazuyuki Nakamura, Yamaguchi University, Japan

10:15-10:30 E&T in India Ravi Sirdesmukh, Institute of Bioinformatics, ITPL, India

10:30-11:05 Genome and Proteome Siqi Liu, Beijing Institute of Genomics, CAS, China

11:05-11:40 Stem Cell Proteome Yu-Ju Chen, Institute of Chemistry, Academia Sinica, Chinese Taipei

11:40-12:15 Secretome Richard Simpson, La Trobe University, Australia

12:15-13:15 Luncheon Seminar

12:15 Software Solutions for Mining Glycoslate Proteomics Datasets David Horn, ThermoFisher

12:35 Accelerating Biomarker and Proteomics Research with TripleTOF™ 5600 System Wenhai Jin, AB SCIEX

12:55 Introducing Technologies Facilitate Biomarker Discovery and Beyond Liu Ning, Bio-Rad

13:15-14:15 Presentation by Young Scientist Travel Award Winners

13:15 Novel Strategy for Drug Target Discovery by Chemical Proteomics Approach Lianghai Hu, Jilin University, China

13:35 HollowFiber Culture System: An Alternative in Sample Preparation in Secretome Studies Qifeng Lin, National University of Singapore, Singapore

13:55 Membrane Proteomics: Opportunity for Mining Cancer Biomarkers Chia-Li Han, Institute of Chemistry, Academia Sinica, Chinese Taipei

14:15-14:50 Cancer Proteome Tadashi Kondo, National Cancer Center Research Institute, Japan


15:05-15:40 Plasma Proteome Mark Baker, Macquarie University, Australia

15:40-16:15 Disease Proteomics Terence Poon, The Chinese University of Hong Kong, Hong Kong SAR, China

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10th Anniversary for CNHUPO & Release of Special Book “Liver Proteome”

Time: 18:20-18:50, May 5, 2012

Venue: Plenary Hall A, China National Convention Center

Moderator: Jun Qin

Schedule:

1. CNHUPO in a Decade

Fuchu He, Honorary President of CNHUPO, Pioneer of CNHUPO

2. Awards for the CNHUPO 10th Anniversary

Xiaohong Qian, Vice President of CNHUPO

※Distinguished Achievement Award: Fuchu He

※Distinguished Mentoring Award: Zihe Rao

※Technology Innovation Award: Yukui Zhang

※Distinguished Service Award: Pengyuan Yang

3. Introduction of “Liver Proteome – A Special Edition”

Pengyuan Yang, President of CNHUPO

4. Ceremony for the Publication of “Liver Proteome–A Special Edition”

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