Scientific program

17/10/2017 (Tuesday)

8:00h-15h00

SBFTE e Divulgação de Farmacologia na Escola Pública (Promoting Pharmacology in Primary Public Schools in Ribeirão Preto) Coordinators: Maria Christina W. Avellar (Unifesp-EPM) and Francois G. Noel (UFRJ) Collaborators: SBFTE Jovem and Local Organizing Committee Escola Neuza Michelutti Marzola. 4 turmas (oitavo ano: 4 Turmas)

9h00-10h00 Room Turquesa

Meeting of the Board of SBFTE Directors and Deliberative Council (Council and Directory Board Members only)

10h00-12h00 Room Turquesa

Meeting of the SBFTE Board of Directors, Deliberative Council and Representative Members with IUPHAR (Secretary General)

12h00-13h00 Lunch

13h00-15h00 Room Ágata

Meeting of the SBFTE Permanent Forum of Graduate Programs in Pharmacology Coordinators and Representative Members from Graduate Programs in Pharmacology Representative Members from Graduate Programs that have Pharmacology in their Curriculum

14h00 Venue Secretariat and SBFTE Secretariat Opening

15h00–16:30 Room Ágata

SBFTE-IUPHAR: building bridges for Cooperative Partnership (Education Initiatives)

• Open Remarks Maria Christina W. Avellar (SBFTE President) SBFTE perspective: Pharmacology in Brazil, Education Initiatives

• IUPHAR Perspective Michael Spedding (IUPHAR)

• Open discussion, final remarks and conclusions

18h30-20h45 Room Rubi

Opening Ceremony

• Special Remarks and Tributes

• SBFTE/Aché Inaugural Senior Pharmacologist Award Award Recipient: João Batista Calixto (CiENP, UFSC)

Opening Lecture: How metabolism and recent human evolution (to run!) opens up new therapeutic opportunities in neurodegeneration and ALS Michael Spedding (IUPHAR) Introduced by: Maria Christina W. Avellar (Unifesp-EPM)

18/10/2017 (Wednesday)

8h00-08h50 Courses

Room Topázio

Farmacogenômica (Pharmacogenomics) Coordinator: Guilherme Suarez Kurtz (INCa) • Class 1: Farmacogênomica: Introdução (Pharmacogenomics: Introduction)

Guilherme Suarez Kurtz (INCa)

Room Safira

Modelos Animais em Farmacologia Translacional (Animal Models in Translational Pharmacology) Coordinator: Iraci L. S. Torres (UFRGS) • Class 1: Modelos animais em farmacologia experimental: Validação e

previsão (Animal models in experimental pharmacology: Validation and prediction) Rosane Gomez (UFRGS)

Room Ágata

Farmacometria e Farmacologia dos Sistemas (Pharmacometrics and System Pharmacology) Coordinator: Bibiana Verlindo de Araujo (UFRGS) • Class 1: Antimicrobianos e antifúngicos (Antimicrobials and Antifungals)

Francine Johansson Azeredo (UFBA)

Room Rubi

Descoberta e Desenvolvimento Pré-Clínico de Fármacos: Abordagem Crítica e Quantitativa das Estratégias e Ensaios (Drug Discovery and Preclinical Development: Critical and Quantitative overview of Strategies and assays) Coordinator: François G. Noël (UFRJ) • Class 1: Desafios e estratégias (Challenges and strategies)

François G. Noël (UFRJ)

09h00-09h50 Lectures

Room Topázio

Glowing pharmacology: Imaging the life and times of G protein coupled receptors Nicholas Holliday (University of Nottingham, UK) Introduced by: Rafael Roesler (UFRGS)

Room Rubi Epithelial proteases and inhibitors: major actors of epithelial homeostasis Nathalie Vergnolle (INSERM, France) Introduced by: Soraia Katia Pereira Costa (USP)

09h50-10h10 Coffee-break

10h10-12h10 Symposia/Oral Communication

Room Topázio

Vascular and endothelial changes associated with pregnancy Chairs: Rita Tostes Passaglia (USP)/Cristina Antoniali Silva (Unesp) • Innate immune mechanisms and maternal vascular dysfunction in

preeclampsia Styliani (Stella) Goulopoulou (University of North Texas, USA)

• Vascular endothelial cell dysfunction in pregnancy complications Sandra T. Davidge (University of Alberta, Canada)

• Alterations in post-translational regulation of eNOS increase NO bioavailability in blood vessels of late pregnant spontaneously hypertensive rats (SHR) Cristina Antoniali Silva (Unesp)

• CO: 06.007 Hydrogen Sulfide (H2S) attenuates hypertension in pregnancy and blunts fetal growth restriction through an increase in placental efficiency in hypertensive pregnant rats. Possomato-Vieira JS, Chimini JS, Santos-Silva ML, Gonçalves-Rizzi VH, Dias-Junior CA IBB-Unesp – Farmacologia

• CO: 01.004 Putative alpha1d / alpha1a-Adrenoceptors heterodimerization in the abdominal aorta from preeclamptic rats Silva KP1, Kiguti LRA1, Lim L2, Kocan M2, Summers RJ2, Caldeira-Dias M1, Sandrim V1, Pupo AS1 1IBB-Unesp – Farmacologia, 2Monash University – Drug Discovery Biology

Room Safira

New vistas on cardiotonic steroids and Na/K-ATPase Chair: Luís Eduardo M. Quintas (UFRJ) • Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse

model with a single disease-mutation in the sodium-potassium pump Karin Lykke-Hartmann (Aarhus University, Denmark)

• The new facet of ouabain in the Central Nervous System (CNS) Elisa Mitiko Kawamoto (USP)

• Effect of Iron Overload on Na/K-ATPase Leandro Augusto de Oliveira Barbosa (UFSJ)

• New insights into cardiotonic steroids-Na/K-ATPase interaction Luís Eduardo M. Quintas (UFRJ)

Room Rubi

Neuroinflammation as a target for the treatment of CNS diseases Chair: Thiago Mattar Cunha (USP) • Antibiotics and neurodegenerative disease: new role for old drugs

Elaine Del Bel (USP) • Cytokines and Alzheimer's disease

Foo Y. Liew (University of Glasgow, UK) • TRP channels play a neuroinflammatory role in Alzheimer’s disease

Maíra Assunção Bicca (Northwestern University) • CO: 05.001 Related mechanisms of C5a/C5aR during neuropathic pain.

Quadros AU1, Fonseca MMD2, Ferreira MD3, Sagar DR4, Cunha FQ2, Chapman V4, Cunha TM2 1FM-USP – Farmacologia, 2FMRP-USP – Farmacologia, 3FMRP-USP – Bioquímica e Imunologia, 4University of Nottingham – School of Life Sciences

• CO: 02.005 Activity-dependent neuronal klotho production induces astrocytic lactate release through FGFR1 activation and ERK phosphorylation. Mazucanti CH1, Kawamoto EM1, Mattson MP2, Camandola S2, Scavone C1 1ICB-USP – Farmacologia, 2NIH-NIA

12h10-13h20 Room Rubi

SBFTE Assembly with Lunch Box

13h30-15h30 Symposia/Oral Communication

Room Topázio

Inflammation: New Therapeutic Frontiers Chairs: John L. Wallace (University of Calgary, Canada)/Marcelo Muscará (USP) • Efferocytosis of apoptotic cells is impaired in elderly humans due to reduced

macrophage TIM-4 expression Derek Gilroy (University College London, UK)

• Inflammation and epigenetic mechanisms are involved on soluble guanylate cyclase (sGC) transcriptional regulation Fabiola Taufic Monica Iglesias (Unicamp)

• Promoting resolution of inflammation: A 3 billion year old solution John L. Wallace (University of Calgary, Canada)

• CO: 01.002 H2S is a key antisecretory molecule against cholera toxin-induced diarrhoea in mice: evidence for non-involvement of the AC/CAMP/PKA pathway and AMPK.

Sousa FBM1, Souza LKM1, Araújo TSL1, Sousa NA1, Araújo S2, Silva RO3, Nicolau LAD3, Souza FM1, Silva IS4, Souza MHLP3, Medeiros JVR2 1Renorbio – Farmacologia, 2UFPI – Farmacologia, 3UFC – Farmacologia e Fisiologia, 4UFMG – Farmacologia e Fisiologia

• CO: 04.008 Resolvin E1 reduces rat paw edema and nociception locally through leukotriene B4 receptor type one.

• Fonseca FCS, Turchetti-Maia RMM, Francischi JN UFMG

Room Safira

Natural Products Chair: Fernanda Regina de Castro Almeida (UFPI) • Pharmacological potential of the natural nitro compound, 1-nitro-2-

phenylethane and its synthetic derivatives as vasorelaxant agents Mohammed Saad Lahlou (UFC) • Monoterpenes as promising substances for the treatment of painful

neuropathies: Role of biotechnology Fernanda Regina de Castro Almeida (UFPI) • CO: 09.017 Zingiber zerumbet promotes arterial vasodilation by blockade

of calcium influx. Graça ACS1, Batista NY1, Pessoa EV1, Pinheiro CCS2, Correa JWN3 1UFAM,

2Inpa, 3UFAM • CO: 05.013 Further investigation of antinociceptive and pronociceptive

mechanisms of Acmella oleracea in mice. Dallazen JL1,2, Maria-Ferreira D1, Luz BB1, Nascimento AM1, Cirpriani TR1,

Souza LM3, Werner MF1 1UFPR, 2Farmacologia, 3Instituto de Pesquisa Pelé Pequeno Príncipe

• CO: 08.007 Esophageal mucosal barrier in different phenotypes of gastroesophageal reflux disease (GERD) patients: Diferential effect of topical protection with sulfated polysaccharide obtained for Gracilaria caudata (GC).

Sales TMAL1, Silva RO2, Nicolau LAD2, Moreira RLR3, Bingana RD3, Alencar POC3, Pereira IS3, Santos AA2,1, Souza MAN1, Barros FCN3, Freitas ALP3, Sifrim D4, Souza MHLP2,1 1UFC – Ciências Médicas, 2UFC – Fisiologia e Farmacologia, 3UFC

• CO: 04.032 Dilodendron bipinnatum extract ameliorates TNBS-induced colitis in rats by inhibiting TNF-α, supporting mucus production and promoting antioxidant effect.

Oliveira RG2,1, Ferreira LA2, Miyajima F3, Pavan E1, Damazo AS1, Martins DTO1 1UFMT – Basic Sciences in Health, Faculty of Medicine, 2UNIC – Pharmacy, 3UFC – Neuropharmacology, Drug Research and Development

Room Rubi

Doutores na Indústria (Doctors in Industry) Chairs: Sanseray da Silveira Cruz-Machado / Juliano Quintella Dantas Rodrigues (SBFTE Jovem) • Doutorado Acadêmico-Industrial – DAI Erik Gustavo Del Conte (UFABC) Sergio Robles Reis de Queiróz (Fapesp) • Cellco Biotec: o destaque está na diferença! Fernando Vasconcelos Maluf (Cellco Biotec)

15h30-15h50 Coffee-break

15h50-16h40 Lectures

Room Topázio

Consensomes: Leveraging publically archived “omics” datasets to illuminate the biology of nuclear receptor signaling pathways Neil J. McKenna (Baylor College of Medicine, USA) Introduced by: Maria Christina W. Avellar (Unifesp-EPM)

Room Rubi

The rational development of novel alosteric modulators of CXCR2 receptors for inflammatory diseases Marcello Allegretti (Dompé, Italy) Introduced by: Emiliano Barreto (UFAL)

16h50-18h50 Symposia / Roundtable

Room Topázio

Purines and inflammation Chair: Patricia Machado Rodrigues e Silva Martins (Fiocruz) • Purinergic signalling in inflammatory bowel diseases

Robson Coutinho Silva (UFRJ) • Low expression of CD39 (ectonucleotidases involved in adenosine synthesis)

on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis Fernando de Queiroz Cunha (USP)

• Role of adenosine in lung fibrosis caused by silica particles in mice Patricia Machado Rodrigues e Silva Martins (Fiocruz)

• CO: 08.003 “Extracellular cAMP-adenosine pathway” modulates airway smooth muscle contraction via A1 receptor activation Pacini ES, Silveira SS, Godinho RO Unifesp-EPM – Farmacologia

• CO: 07.006 The role of adenosine receptor A2A on the hyperactivity of hypothalamus-pituitary-adrenal axis observed in diabetic animals. Buriche ALR, Magalhães NS, Silva PMR, Martins MA, Carvalho VF Fiocruz

Room Safira

Nitros(yl)ation as a Mechanism involved in Disease and Drug Response Chair: Jose Eduardo Tanus dos Santos (USP) • An overview of critical mechanisms regulating nitrosation

José Carlos Toledo Júnior (USP) • Nitros(yl)ation and the antihypertensive responses to oral nitrite

Lucas C. Pinheiro (USP) • The expression of human inducible nitric oxide synthase (NOS-2) and its

splice variants S2 and S3 is associated with the development of colon and breast human tumors Hugo P. Monteiro (Unifesp)

• Nitros(yl)ation in sepsis Jamil Assreuy (UFSC)

Room Ágata

microRNA based therapy Chair: Alice Cristina Rodrigues (USP) • Circulating miRNAs as biomarkers of cardiotoxicity and therapeutic

potential in breast cancer Edilamar Menezes de Oliveira (USP)

• microRNA based therapy - microRNAs in cancer cachexia Robson Francisco Carvalho (Unesp-Botucatu)

• miRNAs from 14q32 region in thyroid cancer: biological role and clinical implication Murilo Vieira Geraldo (Unicamp)

• Roles of non-coding RNAs (microRNAs and lncRNAs) in cardiovascular development, function and disease Da-Zhi Wang (Harvard Medical School, USA)

Room Rubi BD - Flow Cytometry: Cell signaling, death and everything between Renan Antonialli (BD Biosciences) Chair: André Cardoso (BD Biosciences)

18h50-20h20 Poster Session 1

01. Cellular and Molecular Pharmacology (01.001-01.023) 02. Neuropharmacology 02.001-02.022) 03. Psychopharmacology 03.001-03.016 04. Inflammation and Immunopharmacology (04.001-04.036) 05 Pain and Nociception Pharmacology (05.001-05.016) 06. Cardiovascular and Renal Pharmacology (06.001-06.043) 07. Endocrine, Reproductive and Urinary Pharmacology (07.001-07.012) 08 – Respiratory and Gastrointestinal Pharmacology (08.001-08.009) 09. Natural Products and Toxinology (09.001- 09.033) 10. Cancer Pharmacology (10.001-10.015) 11. Clinical Pharmacology, Pharmacokinetics, Pharmacogenomics and

Toxicology (11.001-11.018)

12. Drug Discovery and Development (12.001-12.008) 13. Systems Pharmacology (13.001-13.002) 14. Pharmacology Education and Technology (14.001) 15. Pharmacology: Other (15.001-15.013)

20h30-23h00 Dinner at Restaurante Epicurista (purchase ticket at the Congresss Secretariat)

19/10/2017 (Thursday)

08h00-08h50 Courses

Room Topázio

Farmacogenômica (Pharmacogenomics) Coordinator: Guilherme Suarez Kurtz (INCa) • Class 2: Pharmacogenomics: Current status (Farmacogenômica: Estado

Atual) Guilherme Suarez Kurtz (INCa)

Room Safira

Modelos animais em Farmacologia translacional (Animal models in translational pharmacology) Coordinator: Iraci L. S. Torres (UFRGS) • Class 2: Modelos animais para estratégias terapêuticas (Animal models

for therapeutic strategies) Iraci L. S. Torres (UFRGS)

Room Ágata

Farmacometria e Farmacologia dos Sistemas (Pharmacometrics and System Pharmacology) Coordinator: Bibiana Verlindo de Araujo (UFRGS) • Class 3: Modelagem PK/PD no Desenvolvimento de Fármacos na

Oncologia (PK/PD Modeling in Oncology Drug Development) Maiara Cassia Pigatto (Instituto Vita Nova)

Room Rubi

Descoberta & desenvolvimento pré-clínico de fármacos: Abordagem crítica e quantitativa das estratégias e ensaios (Drug Discovery and Preclinical Development: Critical and Quantitative overview of Strategies and assays) Coordinator: François G. Noël (UFRJ) • Class 2: Tipos de ensaios farmacodinâmicos (Types of pharmacodynamics

assays) François G. Noël (UFRJ)

09h00-09h50 Keynote Lecture

Room Rubi What is Systems Pharmacology? For sure no longer Pie in the Sky! Amin Rostami-Hochaghan (University of Manchester, UK) Introduced by: Teresa Dalla Costa (UFGRS)

09h50-10h10 Coffee-break

10h10-12h10 Symposia/Oral communication

Room Topázio

From big data to system biology Chair: Pedro Augusto Carlos Magno Fernandes (USP) • Post-transcriptional control involving miRNA-mRNA interactions in the

immune tolerance Geraldo Aleixo da Silva Passos Junior (USP)

• Big Data: linking arrows to targets Pedro Augusto Carlos Magno Fernandes (USP)

• CO: 13.001 Is body weight gain under regulation of circadian melatonin? Cruz-Machado SS1, Pereira EP1, Oliveira AP2, Silva-Souza E1, Markus RP1 1IB-USP – Departamento de Fisiologia, 2UFPI – Biologia e Fisiologia

• CO: 12.011 New QSAR method based on the molinspiration computer platform for discovering new drugs. Antunes JE1, Fernandes GS2, Pereira MBM3 1UFJF – Farmácia, 2UFJF – Acadêmico, 3 Ciências Básicas em Saúde, UFJF

• CO: 13.002 Early-life stress promotes alterations in intestinal permeability and hippocampal 5-HT 1A mRNA expression in juvenile rats. Bravo JA1, Astudillo-Guerrero C1, Rossi-Vargas G1, Escobar-Luna J1, Barrera-Bugueño C1, Gotteland M2, Julio-Pieper M1 1Pontificia Universidad Católica De Valparaíso – NeuroGastroBioquímica, 2Universidad de Chile – Nutrición

Room Ágata

Oxidative stress, inflammation and increased protease activity in cardiovascular diseases Chairs: Michele Mazzaron de Castro (USP) / Lusiane Maria Bendhack (USP) • Cytokines, Toll-like receptors and heart failure

Pawan K. Singal (University of Manitoba, Canada) • The crosstalk between aldosterone and inflammation in the

cardiovascular system Rita de Cassia Aleixo Tostes Passaglia (USP)

• Redox regulation of hepatic lipid metabolism and its effects on the cardiovascular system Markus Michael Bachschmid (Boston University, EUA)

• Matrix metaloproteinases and oxidative stress in the vascular remodeling of hypertension Michele Mazzaron de Castro (USP)

Room Rubi

Alternative tests to the use of animals in pre-clinical studies Chair: João B. Calixto (CIEnP) • Reconstructed Human Epidermis for safety assessment and early drug

development Rodrigo De Vecchi (Episkin Academy)

• Interlaboratorial comparison applied to non-animal alternative methods Áurea Valadares Folgueras-Flatschart (Inmetro)

• Standardization of cutaneous permeation tests and in vitro release by using vertical diffusion system (Franz cell) João B. Calixto (CIEnP)

Room Rubi

12h10-13h20 Meet the Professor with Lunch Box (pre-registered participants only) Chair: SBFTE Jovem Committee

Openning Managing your and others creativity, and avoiding mistakes Michael Spedding (IUPHAR) • Amin Rostami-Hochaghan University of Manchester, UK) • Concepción Peiró Vallejo (Universidad Autónoma de Madrid, Spain) • Derek Gilroy (University College London, UK) • Emiliano de Oliveira Barreto (UFAL) • Foo Y. Liew (University of Glasgow, UK) • Maria Laura Bolognesi (Universty of Bologna, Italy) • Michael Spedding (IUPHAR) • Neil J. McKenna (Baylor College of Medicine, USA) • Nicholas Holliday (University of Nottingham, UK) • Rafael Roesler (Universidade Federal do Rio Grande do Sul (UFRGS) • Sandra Davidge (University of Alberta, Canada) • Sharon Prince (University of Cape Town, South Africa)

13h30-15h30 Symposia/Oral communication

Room Topázio

José Ribeiro do Valle Award Chair: Maria Christina W. Avellar (Unifesp-EPM) JRV Evaluation Committee:

Edson Antunes (Session Coordinator, Unicamp) Concepción Peiró Vallejo (Universidad Autónoma de Madrid, Spain) Sharon Prince (University of Cape Town, South Africa)

Finalist 1: Ana Elisa Gonca̧lves • 02.010 Evaluation of anti-Alzheimer effects of tacrine dimers in animals

with peptide Aβ1-42-induced Alzheimer. Gonçalves AE1, Mariano LNB1, Silva LM1, Aquino RAN, Fatima A2, Andrade SF1, Souza MM1 1Univali – Ciências Farmacêuticas, 2UFMG – Química

Finalist 2: Bruno Marcel Silva de Melo • 04.026 The alarmin S100A9: A key target for treatment of psoriasis. Melo

B1, Protasio F1, Prado D1, Costa L2, Souza C2, Lima D3, Nakaya H3, Cunha T1, Cunha F1, Alves-Filho JC1 1FMRP-USP – Farmacologia, 2FMRP-USP, 3FCF-USP – Análises Clínicas e Toxicológicas

Finalist 3: Bryelle Eccard de Oliveira Alves • 06.008 Novel DPP4 inhibitor reduces cardiac and vascular dysfunction

induced by diabetes Type 2 in rats. Eccard B1, Reina E1, Araújo JSC1, Barreiro EJ1, Lima LM1, Trachez MM2, Sudo RT1, Zapata-Sudo G1 1UFRJ, 2UFF

Finalist 4: Fernando Olinto Carreño • 11.001 Lipid core nanocapsules modulate quetiapine hippocampal exposure

in a neurodevelopmental model of schizophrenia. Carreño F1, Helfer VE1, Staudt KJ1, Paese K1, Meyer FS1, Silva CM1, Herrmann AP2, Rates SMK1, Guterres SS1, Dalla Costa T1 1UFRGS, 2UFFS

Finalist 5: Lucas Antonio Duarte Nicolau • 08.002 Promissingtherapeutic approach in GERD: Topical protection to

oesophageal mucosa and anti-inflammatory outcome of a biopolymer in mice and human biopsies. Nicolau LAD1,2, Batista-Lima FJ1, Santana AP1, Sales TM3, Oliveira TM4, Medeiros JVR4, Silva DA4, Vale ML1, Nobre-e-Souza MA3, Santos AA1, Sifrim D2, Souza MHP1 1UFC – Fisiologia e Farmacologia, 2Queen Mary University of London – Neurogastroenterology, 3UFC – Ciências Médicas, 4UFPI – Biotecnologia

Room Rubi

Cannabis-based drugs Chair: Alline Cristina Campos (USP) • THC, GPR119 and the metabolic syndrome

Kenneth Paul Mackie (Indiana University, USA) • (−)-β-Caryophyllene, a CB2 receptor-selective phytocannabinoid, suppresses

motor paralysis and neuroinflammation in a murine model of multiple sclerosis Rafael Cypriano Dutra (UFSC)

• Cannabinoids, neuroplasticity and Antidepressant Drugs: Is there a Link? Alline Cristina Campos (USP)

• CO: 02.007 The BNST endocannabinoid system modulates learned, but not innate fear in rats. Borges-Assis AB, Uliana DLM, Resstel LBM FMRP-USP – Farmacologia

• CO: 03.011 Cocaine oral self- administration by ADHD male and female rats with neonatal injury with 6-OHDA. Fernandes PR, Umpierrez LS, Barros HMT UFCSPA

Room Ágata

Design, discovery and development of multitarget drug candidates Chair: Carlos Alberto Manssour Fraga (UFRJ) • Polypharmacology in a single drug: multitarget drugs against complex

diseases Maria Laura Bolognese (University of Bologna, Italy)

• Searching new multi-target directed drug candidate prototypes for Alzheimer’s disease: a case of novel feruloyl-donepezil hybrids Claudio Viegas Júnior (Unifal)

• Discovery of multitarget prototypes for treatment of multifactorial diseases: N-acylhydrazone framework as privileged structure Carlos Alberto Manssour Fraga (UFRJ)

• CO: 06.066 Effect of PDE9 Inhibitor (BAY 73-6691) on the contractile response of cavernous smooth muscle of heart failure rats submitted to treatment with tadalafil. Janussi SC, Tartarotti SP, Mora AG, Andrade DR, Barbosa JWP, Priviero F, Claudino MA USF – Multidisciplinary Research

• CO: 04.004 Quercetin suppression of pulmonary fibrosis triggered by silica particles in Swiss-Webster mice. Guimarães FV, Ferreira TPT, Arantes ACS, Alexandre TL, Martins MA, Silva PMR Fiocruz – Inflamação

15h30-15h50 Coffee-break

15h50-17h20 Roundtable

Room Rubi

Brazilian Pharmacology and IUPHAR: Building bridges for collaborative partnership Chair: Maria Christina W. Avellar (Unifesp-EPM)

• IUPHAR, How to address modern molecular pharmacology via international collaboration: impact on drug discovery and development, and on natural products

Michael Spedding (IUPHAR)

• SBFTE’s Remarks

• Open discussion, Conclusions

17h30-18h20 Lectures

Room Topázio

Targeting the oncogenic TBX3 and its co-factor, nucleolin, in anti-cancer drug development Sharon Prince (University of Cape Town, South Africa) Introduced by: Leticia V. Costa Lotufo (USP)

Room Rubi

Mechanisms of pain and neuro-immune communication in bacterial host defense Isaac M. Chiu (Harvard Medical School, USA) Introduced by: Waldiceu Aparecido Verri Junior (UEL)

19h30 23h00 Social Event: Dinner/dance party (to all attendees) Cervejaria Invicta

20/10/2017 (Friday)

08h00-08h50 Course

Room Topázio

Farmacogenômica / (Pharmacogenomics) Coordinator: Guilherme Suarez Kurtz (INCa) • Class 3: Farmacogenômica: Implementações Clínicas (Pharmacogenomics:

Clinical implementation) Guilherme Suarez Kurtz (INCa)

Room Safira

Modelos animais em Farmacologia translacional/(Animal models in translational pharmacology) Coordinator: Iraci L. S. Torres (UFRGS) • Class 3: Drosophila como modelo para prospecção de fármacos

(Drosophila as a suitable model for drug screening) Régis Adriel Zanette (UFRGS)

Room Ágata

Farmacometria e Farmacologia dos Sistemas (Pharmacometrics and System Pharmacology) Coordinator: Bibiana Verlindo de Araujo (UFRGS) • Class 2: Modelagem PK/PD aplicado ao diabetes (PK-PD modeling applied

to diabetes) Bibiana Verlindo de Araújo (UFRGS)

Room Rubi

Descoberta & desenvolvimento pré-clínico de fármacos: Abordagem crítica e quantitativa das estratégias e ensaios (Drug Discovery and Preclinical Development: Critical and Quantitative overview of Strategies and assays) Coordinator: François G. Noël (UFRJ) • Class 3: Fluxograma de ensaios: In vitro, in vivo e clínico (Assays flow

chart: in vitro, in vivo and clinical) François G. Noël (UFRJ)

09h00-09h50 Lectures

Room Topázio

Neuroplasticity in stress-related neuropsychiatric disorders: new paths for drug discovery Maurizio Popoli (University of Milan, Italy) Introduced by: Francisco S. Guimarães (USP)

Room Rubi

Adipokines, endothelial dysfunction and vascular damage: A role for interleukin-1beta Concepción Peiró Vallejo (Universidad Autónoma de Madrid, Spain) Introduced by: Andre S. Pupo (Unesp)

10h00-11h30 Poster Session 2 with Coffee break

11h30-12h40 Keynote Speaker: Sergio Ferreira Memorial Lecture

Room Topázio

Melatonin – the ubiquitous indolamine – multiple sources, multiple targets – New pharmacological chapter? Regina P. Markus (USP) Chair: Maria Christina W. Avellar (Unifesp-EPM) Introduced by Leticia Lotufo (USP)

12h40-13h50 Closing Session

Room Topázio Awards and Prize Announcements Closing Ceremony