TECHNOLOGY THAT NEVER SLEEPS!™

Blood Reflux Protection 24/7!™Ant i -Ref lux Technology Prov ides

NEXUS TKO®

Specialty Neonatal/PediatricSafety In fus ion Sets

Special ty Neonatal IV SetsNexus TKO ®

Nexus TKO ® Specialty Neonatal IV Sets are designed exclusively for Neonatal Intensive CareExtension Sets and T-Sites with Spin-Lock or Slip Luers in various tubing sizes to fit the need for low medication priming volumeMultiple tubing set lengths from 3” to 60” with Multi-Color Pinch or Slide ClampsManufactured from Non-DEHP and Latex Free materials

Normal Closed PositionThe TKO valve provides

Blood Reflux Protection 24/7!™

Blood Sample/Patency CheckThe TKO valve opens in

reverse for easy blood draw

Patented 3‐position Anti‐Reflux technology provides IV Catheter Patency 24/7 ! ™To Keep Open | Catheter Patency Technology

Neonatal Safety Catheter Extension Sets & T-Site Extension Sets Safety Connections

Nexus Tri-Seal ™ Microbial Barrier Protection

96-Activation Microbial Barrier Performance Study6 Tri-Seal Design Provides (3) Levels of Validated Microbial Ingress Protection3,6

1 st Level of ProtectionA 360° compression seal between the septum and the rigid needle-free connector housing provides a 360° barrier of protection from microbial ingress3,6

2nd Level of ProtectionA smooth, easy to disinfect septum surface with our exclusive Slit-Lock™ technology assures the septum slit is fully locked and sealed, which provides a safe and effective microbial barrier seal3,6

3rd Level of ProtectionThe Slit-Lock™ septum remains closed until the male luer fully compresses the locked septum slit inside the needle free housing, further protecting the internal fluid path from microbial ingress3,6

Patented Clear, Single Piece TechnologyNexus TKO® Anti-Reflux technology, delivers IV Catheter Patency 24/7! ™ with a single crystal clear silicone Anti-Reflux valve

Blood Reflux Protection 24/7! ™

Nexus TKO® technology decreases the risk of infection by preventing blood reflux; a known contributor to catheter related blood stream infections CRBSI’s3,5

Flush/InfusionThe TKO valve opens forwardwith normal gravity pressure

Lever Lock

Cannula

Spin-Lock T-Site

Slip Luer T-Site

Male Luer Lock

Spin-Lock Male Luer

All Specialty Neonatal IV Sets are manufactured with our Nexus TKO® Anti-Reflux technology. Our innovative safety IV sets assure catheter patency is achieved and the risk of CRBSI’s due to blood reflux is reduced3,5. The TKO Anti-Reflux valve is normally closed but automatically opens towards the patient with the smallest amount of infusion pressure. When fluid pressure drops due to physiological

changes (such as patient movement, crying, sneezing, coughing, venous spasms, or venous pressure) or mechanical changes (such as infusion pump fill cycles, syringe plunger reflux, IV bag run dry, luer connections, disconnections, roller clamping, or external pressure changes from ventilators) the TKO Anti-Reflux valve will automatically close to prevent blood from refluxing into the patient’s

catheter. The Nexus TKO® valve will remain closed against vascular pressure ensuring IV Catheter

Patency 24/7!™ 2.

Phone - 866.336.3987 | Fax - 913.451.2363 | www.nexusmedical.comN e x u s M e d i c a l , L L C | 1 1 3 1 5 S t r a n g L i n e R o a d | L e n e x a | K a n s a s | 6 6 2 1 5

Nexus TKO ® Multi-Access Neonatal Safety IV Sets

Provide Protection Against Touch ContaminationProvide Protection Against Drug Mixing

Phone - 866.336.3987 | Fax - 913.451.2363 | www.nexusmedical.comN e x u s M e d i c a l , L L C | 1 1 3 1 5 S t r a n g L i n e R o a d | L e n e x a | K a n s a s | 6 6 2 1 5

Multi-Access Neonatal Safety IV SetsNexus TKO ®

Bi-Fuse, Tri-Fuse &

Nexus Medical designed a wide range of innovative Nexus TKO® Multi-Access Neonatal IV Sets. Our innovative line of IV sets are pre-assembled with needle free Nexus TKO® Anti-Reflux valve protection on each IV line whether you choose a bi, tri or quad configuration. This specialty designed group of IV sets handles the complex challenges of continuous IV nutrition therapy, drug therapy and intermittent IV delivery of low volume, small dosage medications and drugs.

Nexus TKO® Anti-Reflux technology extends catheter life by providing Blood Reflux Protection 24/7!™ for neonatal patients and their limited vasculature which is crucial to delivering life-sustaining nutrition, medications and drugs. Nexus TKO® Anti-Reflux technology protects each IV line by reducing the risk of mixing during simultaneous infusions of nutrition, medication and drugs.

Quad-Fuse Safety IV Sets

Nexus TKO ® Anti-Reflux Technology provides Blood Reflux Protection 24/7!™ and the associated risk of CRBSI’s3,5

Reduce the Risk of CRBSI’s from Blood Refluxby using the Nexus TKO® Anti-Reflux valve coupled with our Multi-Access Neonatal Safety IV Sets. These safety sets will assure catheter patency is achieved and the risk of CRBSI’s due to blood reflux are reduced3,5

Reduced Risk of CRBSI’s from Touch Contamination with pre-assembled and patient ready Nexus TKO® Multi-Access Neonatal Safety IV Sets, designed to deliver a standardized safety solution by reducing the total number of line connections/disconnections and the potential unwanted risk of touch contamination which is proven to cause CRBSI’s7

Standardized Protection and Safety Solution is achieved with Nexus TKO® Multi-Access Neonatal Safety IV Sets by allowing the Clinician to choose the most efficient configuration to safely deliver the patient’s specific pharmaceutical formulary. Nexus Neonatal Safety IV Sets are designed with optimum tubing lengths, priming volumes and filtration for your patient’s protection

Nexus TKO ® Provides Protection against Medication Mixingwith pre-assembled IV sets offering a new level of safety by reducing drug, medication and nutrition line mixing. Nexus TKO® Anti-Reflux valve technology automatically closes when fluid pressures drop from multiple pump infusions then reopens when fluid pressures resume6.

Minimize Potential Costly Drug Waste and Drug Incompatibilitywith our Nexus TKO® Bi-Fuse, Tri-Fuse and Quad-Fuse Multi-Access Neonatal IV Sets, designed to provide added safety and protection

Low Priming Volumes provide a design solution for low drug waste concerns

Safety Color Coded Clamps provide a visual aid to the Clinician to distinguish between specific IV lines; drugs, medications and nutrients

Non-DEHP and Latex Free

™

™

™

Safety Connections

Bi-Fuse Spin-Lock Connector

Tri-Fuse Spin-Lock Connector

Quad-Fuse Spin-Lock Connector

Filters

Colored Slide Clamps

.22 micron

MED

LIPIDMED

1.2 micron

HAL/TPN

Bi

Tri

Quad

Nexus TKO ® Multi-Access Neonatal Closed Infusion System

Designed to Protect Against CRBSI’s by Reducing the Total Number of Line Connections/Disconnections and Touch Contamination7

Comprehensive System to Assure Reductions in Line Openings and Line Violations

Multi-Access Neonatal Closed Infusion SystemNexus TKO ®

Safety Connections

Provides Blood Reflux Protection 24/7! ™Promotes IV Catheter Patency 24/7! ™Significantly reduces medication mixing by protecting each IV line separately Significantly reduces the risk of CRBSI’s associated with unintentional blood refluxIncreased catheter life by reducing unintentional blood reflux

Nexus TKO ® Anti-Reflux Technology

Nexus TKO ® Neonatal Closed Infusion SystemProvides a significant reduction in the total number of line connections/disconnections through the use of a single, standardized closed system set Promotes standard of practice by providing a unique Closed System designed specifically for the IV nutrition and medication delivery your patient requires Safety color coded clamps provide a visual aid to the Clinician to distinguish between specific IV lines; drugs, medications and nutrients

Vented Spike

Pinch Clamp with Caution Label

One Way Check Valve

2-Way Stop CockThe Nexus TKO ® Anti-Reflux Valve decreases the risk of infection by preventing Blood Reflux Protection 24/7 ™, which is a known contributor to catheter related blood stream infections (CRBSIs)3,5.

The Patented Clear, Single Piece Nexus TKO ® Anti-Reflux Valve was designed to have three positions; the TKO valve will open toward the patient with the smallest amount of fluid pressure, close when not infusing to prevent blood reflux into your patient’s catheter and open in reverse for easy blood sampling or patency check, but automatically reset into the closed position upon syringe disconnection. Nexus TKO® technology has been proven to significantly increase IV catheter life by reducing blood reflux, which is the root cause of most thrombotic catheter occlusions3,5. Nexus TKO® valve will remain closed against vascular pressure, assuring your catheter remains patent2.

Nexus Fully Closed, Multi-Access Infusion Setsprovide a completely sealed structure and clinical method for intermittent flushing and medication infusions. This system, when implemented provides a comprehensive Closed Multi-Access technique which can be used to assure a complete reduction in the overall number of line openings and line violations.

Colored Slide Clamps

MED

LIPIDMED

HAL/TPN

Phone - 866.336.3987 | Fax - 913.451.2363 | www.nexusmedical.comN e x u s M e d i c a l , L L C | 1 1 3 1 5 S t r a n g L i n e R o a d | L e n e x a | K a n s a s | 6 6 2 1 5

Bi-Fuse, Tri-Fuse & Quad-Fuse Neonatal Closed Infusion Sets

TECHNOLOGY THAT NEVER SLEEPS!™NEXUS TKO®

Nexus Medical, LLC | 11315 Strang Line Road | Lenexa | Kansas | 66215 | Phone - 866.336.3987 | Fax - 913.451.2363 | www.nexusmedical.com

1. Jasinksy LM, Wurster J. Occlusions Reduction and Heparin Elimination Trial using an Anti-Reflux Device on Peripheral and Central Intravenous Lines. Journal of Infusion Nursing, 2009; 32(1):33-39. Erratum: 2009; 32(4):194-195. 2. Mitch S. RN, CRNI, Brandmeyer B, RN, BSN. PICC and Midline Catheter Occlusion Rates: A Prospective Study Comparing the Interlink Split Septum Device versus Nexus TKO Split Septum Pressure Activated Anti-Reflux Valve. 3. Jarvis W, MD. Choosing the Best Design for Intravenous Needleless Connectors to Prevent HA-BSI. Infection Control Today, 2010 Aug. 4. Hadaway L, RN, C, CRNI, MEd. Reopening the Pipeline. Nursing, 2005; 35(8):54-61. 5. Timsit J, Misset B, Carlet J et.al. Central Vein Catheter-Related Thrombosis in Intensive Care Patients: Incidence, Risks Factors, and Relationship with Catheter-Related Sepsis. CHEST, 1998; 114(1):207-213. 6. 96-Activation Microbial Barrier Performance Study, GLP Laboratory Testing. Results on file at Nexus Medical LLC. 7. Aly H, Herson V, Duncan A et. al. Is Bloodstream Infection Preventable Among Premature Infants? A Tale of Two Cities. PEDIATRICS, 2005; 115(5):1513-1518. *additional references shown used in other Nexus literature found online at www.nexusmedical.com

Nexus TKO ®-5Nexus TKO ®-6Luer-Activated Anti-Reflux Device Split Septum Anti-Reflux Device