SAFC Supply Solutions3050 Spruce StreetSaint Louis, MO 63103Tel: 800-244-1173 (US Toll Free)

+44 161 232 5500 (Europe)+1-314-534-4900 (International)

Global Email: safcglobal@sial.com

ProClin®

Preservative

ProClin preservatives are an excellent choice

for replacing thimerosal, sodium azide and

gentamicin preservatives. In addition they are

highly effective, broad-spectrum biocides for

controlling microorganisms in reagents and

products intended for in vitro diagnostics use.

At concentrations as low as 0.02%, these

preservatives eradicate bacteria, fungi and

yeast for extended periods of time.

For further information or to obtain a

preservative efficacy study performed by

an independent laboratory contact your

SAFC representative.

Key features of ProClin preservatives:

• Compatibility with key enzymes and

assay indicators

• Will not inhibit antibody binding

• Easy-to-use water-soluble liquid, effective

at very low concentrations (6-20ppm)

• Excellent stability over a wide pH range

(2 to 8.5)

• Level of active ingredients assayable by

HPLC (Inquire for a HPLC standard)

• At recommended usage levels, ProClin

presents no health hazards, toxological

problems or disposal issues

Mechanism of Action

The active components of ProClin are two

isothiazolones, 2-methyl-4-isothiazolin-3-one

and 5-chloro-2-methyl-4-isothiazolin-3-one.

Within minutes of contacting a

microorganism, the active components

penetrate the cell wall and inhibit specific

enzymes (at the points noted in red in the

Krebs Cycle). Growth, macromolecule

synthesis and respiration are inhibited,

ultimately leading to cell death.

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ProClin®

Packaging

SAFC Supply Solutions™Tel: 800-244-1173 (US Toll Free)

+44 161 232 5500 (Europe)+1-314-534-4900 (International)

Email: safcglobal@sial.com

ProClin Evaluation Kits are available for determining the suitability of ProClin products in new

product development. Each evaluation kit contains three different manufactured lots of ProClin

for testing performance consistency from lot to lot.

To determine the appropriate ProClin product for a specific application, ProClin variety kits are

also available. Each kit contains 5 ml of Proclin 150, 200, 300 and 950.

ProClin Evaluation Kits

)srebmun tol 3( lm5 x 3– 051 nilCorP12184

49381-U ProClin 150 – 3 x 400ml (3 lot numbers)

48911-U ProClin 300 – 3 x 5ml (3 lot numbers)

48119-U ProClin Variety Kit – 5ml each of ProClin 150, 200, 300 & 950 as an aid to selectthe appropriate ProClin product for a specific application

Features

Active (A.I.)

ProClin 150

CMIT/MIT

ProClin 200

CMIT/MIT

ProClin 300

CMIT/MIT

ProClin 950

MIT

5.935.15.1.I.A latot %

Salt Stabilizers 23 – 25% Mg salts 3% Mg salts Alkyl Carboxylate none

Matrix Water Water Propylene glycol Water

Working pH Range 2.5 – 8.5 2.5 – 8.5 2.5 – 8.5 2 – 12

Typical Dosage Levels 0.05 – 0.10% 0.05 – 0.10% 0.02 – 0.07% 0.05 – 0.10%

Shelf Life 3 years 3 years 3 years 24 months

ProClin Preservatives

Catalog No. Description

33360-U ProClin Reference Standard-1ml

ProClin 150

49376-U 50ml

49377-U 400ml

49378-U 3.6L

49379-U 15L (Pail)

49380-U 110kg (106.8L)

ProClin 200

48171-U 50ml

500380 400ml

500399 3.6L

500402 15L (Pail)

ProClin Preservatives

Catalog No. Description

ProClin 300

48912-U 50ml

48914-U 400ml

48915-U 2.0L

48916-U 2.8L

48917-U 3.6L

48918-U 18L (Pail)

48919-U 110kg (106.8L)

ProClin 950

46885-U 5ml

46878-U 50ml

46879-U 400ml

46883-U 3.6L

46884 17L (Pail)

02758-504321

JRG

0077

© 2007 SAFCAll rights reserved. Reproduction forbidden without permission.

ProClin is a registered trademark of the Rohm & Haas Company. SAFC Supply Solutions is a trademark of Sigma-Aldrich Biotechnology LP.

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