s100a8 /s100a9
DESCRIPTION
SJIA. SJIA. F. Q. KD. FI. F. Q. KD. FI. Relative DIGE MEASUREMENTS. Relative ELISA MEASUREMENTS. A2M. APOA1. CRP. HP. S100A9. S100A8. SAA. SAP. A2M. APOA1. CRP. HP. S100A8 /S100A9. SAA. SAP. Figure 4. C. A. B. D. Training set n = 24. Testing set n = 20. - PowerPoint PPT PresentationTRANSCRIPT
S100A8/S100A9
Rela
tive
DIG
E M
EASU
REM
ENTS
F KD FISJIA
APOA1 SAPCRP HP S100A9 SAAS100A8A2M
Q
Figure 4
F KD FISJIA
APOA1 SAPCRP HP SAAA2M
Q
Rela
tive
ELIS
A M
EASU
REM
ENTS
A
Biomarker panelof 7 members
1. A2M
2. APO AI
3. CRP
4. HP
5. S100A8/S100A9
6. SAA
7. SAP
Training setn = 24
12 12
Clinicaldiagnosis F Q
n =
LDA
11 1
1 11
Classified as F
Classified as Q
PercentAgreementwith clinical
diagnosis
91.6% 91.6%+ -
91.6%
Overall
P = 1.0 E -4
Testing setn = 20
10 10
Clinicaldiagnosis F Q
n =
Testing
8 3
2 7
Classified as F
Classified as Q
PercentAgreementwith clinical
diagnosis
80% 70%+ -
75%
Overall
P = 7 E -2
C D
SJIA SJIA
BTraining
SJIA F SJIA Q SJIA F SJIA Q
Testing
Pred
icte
d pr
obab
ilitie
sPatient samples
Figure 5
P*= 9.6E -6 P*=4 E -3
E
CRP : AUC=0.82panel : AUC=0.95
ESR : AUC=0.96
Sen
sitiv
ity
S100A8/S100A9 : AUC=0.73
1- Specificity
CRP : AUC=0.65panel : AUC=0.82
ESR : AUC=0.86
Sen
sitiv
ity
S100A8/S100A9 : AUC=0.78
1- Specificity
Sen
sitiv
ity
CRP : AUC=0.72panel : AUC=0.94
ESR : AUC=0.92S100A8/S100A9 : AUC=0.74
1- Specificity
Training Set Testing Set Training + Testing Set
Figure 5
Training setn = 23
13 10
Clinicaldiagnosis F Q
n =
LDA
10 5
3 5
Classified as F
Classified as Q
PercentAgreementwith clinical
diagnosis
76.9% 50%+ -
65.2%
Overall
P = 0.41
Testing setn = 15
10 5
Clinicaldiagnosis F Q
n =
Testing
3 0
7 5
Classified as F
Classified as Q
PercentAgreementwith clinical
diagnosis
30% 100%+ -
53.3%
Overall
P = 0.20
B C
POLY POLY
D
1- Specificity
CRP : AUC=0.64
POLY F vs. Q
panel : AUC=0.64
Sen
sitiv
ity
ATraining
PF PQ PF PQ
Testing
Pred
icte
d pr
obab
ilitie
s
Patient samples
Supplementary Figure 5
Figure 6
Training setn = 59
22 37
Clinicaldiagnosis
n =
LDA
16 3
6 34
PercentAgreementwith clinical
diagnosis
72.8% 91.9%+ -
84.7%
Overall
P = 4.3E -7
SJIAF
1022 27
SJIAF KD + FI
NOTSJIA F
Classified as SJIA F
Classified as NOT SJIA F
A. Pr
edic
ted
prob
abili
ties
Patient samples
SJIA FKD FI
KD + FI
B
CRP : AUC=0.627panel : AUC=0.801
ESR : AUC=0.661
Sen
sitiv
ity
S100A8/S100A9 : AUC=0.543
1- Specificity
5 10
Clinicaldiagnosis QF QQ
n =
LDA
4 0
1 10
Classified as QF
Classified as QQ
PercentAgreementwith clinical
diagnosis
80% 100%+ -
93.3%
Overall
P = 3.7 E -3
BSJIA
C
CRP : AUC=0.82panel : AUC=0.90
ESR : AUC=0.68
A
Pred
icte
d pr
obab
ilitie
s
Patient samples
QQ QF
Sen
sitiv
ity
1- Specificity
S100A8/S100A9 : AUC=0.74
Figure 7
Figure 8