Download - S100A8 /S100A9
S100A8/S100A9
Rela
tive
DIG
E M
EASU
REM
ENTS
F KD FISJIA
APOA1 SAPCRP HP S100A9 SAAS100A8A2M
Q
Figure 4
F KD FISJIA
APOA1 SAPCRP HP SAAA2M
Q
Rela
tive
ELIS
A M
EASU
REM
ENTS
A
Biomarker panelof 7 members
1. A2M
2. APO AI
3. CRP
4. HP
5. S100A8/S100A9
6. SAA
7. SAP
Training setn = 24
12 12
Clinicaldiagnosis F Q
n =
LDA
11 1
1 11
Classified as F
Classified as Q
PercentAgreementwith clinical
diagnosis
91.6% 91.6%+ -
91.6%
Overall
P = 1.0 E -4
Testing setn = 20
10 10
Clinicaldiagnosis F Q
n =
Testing
8 3
2 7
Classified as F
Classified as Q
PercentAgreementwith clinical
diagnosis
80% 70%+ -
75%
Overall
P = 7 E -2
C D
SJIA SJIA
BTraining
SJIA F SJIA Q SJIA F SJIA Q
Testing
Pred
icte
d pr
obab
ilitie
sPatient samples
Figure 5
P*= 9.6E -6 P*=4 E -3
E
CRP : AUC=0.82panel : AUC=0.95
ESR : AUC=0.96
Sen
sitiv
ity
S100A8/S100A9 : AUC=0.73
1- Specificity
CRP : AUC=0.65panel : AUC=0.82
ESR : AUC=0.86
Sen
sitiv
ity
S100A8/S100A9 : AUC=0.78
1- Specificity
Sen
sitiv
ity
CRP : AUC=0.72panel : AUC=0.94
ESR : AUC=0.92S100A8/S100A9 : AUC=0.74
1- Specificity
Training Set Testing Set Training + Testing Set
Figure 5
Training setn = 23
13 10
Clinicaldiagnosis F Q
n =
LDA
10 5
3 5
Classified as F
Classified as Q
PercentAgreementwith clinical
diagnosis
76.9% 50%+ -
65.2%
Overall
P = 0.41
Testing setn = 15
10 5
Clinicaldiagnosis F Q
n =
Testing
3 0
7 5
Classified as F
Classified as Q
PercentAgreementwith clinical
diagnosis
30% 100%+ -
53.3%
Overall
P = 0.20
B C
POLY POLY
D
1- Specificity
CRP : AUC=0.64
POLY F vs. Q
panel : AUC=0.64
Sen
sitiv
ity
ATraining
PF PQ PF PQ
Testing
Pred
icte
d pr
obab
ilitie
s
Patient samples
Supplementary Figure 5
Figure 6
Training setn = 59
22 37
Clinicaldiagnosis
n =
LDA
16 3
6 34
PercentAgreementwith clinical
diagnosis
72.8% 91.9%+ -
84.7%
Overall
P = 4.3E -7
SJIAF
1022 27
SJIAF KD + FI
NOTSJIA F
Classified as SJIA F
Classified as NOT SJIA F
A. Pr
edic
ted
prob
abili
ties
Patient samples
SJIA FKD FI
KD + FI
B
CRP : AUC=0.627panel : AUC=0.801
ESR : AUC=0.661
Sen
sitiv
ity
S100A8/S100A9 : AUC=0.543
1- Specificity
5 10
Clinicaldiagnosis QF QQ
n =
LDA
4 0
1 10
Classified as QF
Classified as QQ
PercentAgreementwith clinical
diagnosis
80% 100%+ -
93.3%
Overall
P = 3.7 E -3
BSJIA
C
CRP : AUC=0.82panel : AUC=0.90
ESR : AUC=0.68
A
Pred
icte
d pr
obab
ilitie
s
Patient samples
QQ QF
Sen
sitiv
ity
1- Specificity
S100A8/S100A9 : AUC=0.74
Figure 7
Figure 8
