The editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following

colleagues who acted as Guest Editors for Specific Fields in 1980:

Additionally, sincere thanks are due to 497 of our colleagues not on the Editorial Advisory Board who reviewed articles for the

Journal in 1980.

872

Edmund G. Anderson

Lewis Aronow

Uoyd Beck

John A. Bevan

David A. Blake

Theodore M. Brody

Edward J. Cafruny

Leonard Cook

William C. de Groat

Bahjat A. Faraj

Lawrence J. Fischer

Shri N. Gin

Leon GoJdberg

Dora B. Goldstein

Garrett J. Gross

John Harvey

Donald J. Jenden

Louis Lemberger

Roberto Levi

Louis Levy

Kafait U. Malik

Perry Molinoff

John C. McGiff

D. E. McMillan

David E. Potter

Arthur Raines

Lewis Seiden

Parkhurst Shore

Roger Smith

Solomon Snyder

Ewart Swinyard

David J. Tniggle

Norman Weiner

Theodore C. West

David P. Westfall

Thomas Westfall

Dixon M. Woodbury

Richard J. Wurtman

Ben Zimmerman

874 INDEX

and withdrawal (rats), 666effects of mazindol and homo-

logs (rats), 745effects of naltrexone dose and

history of naltrexone expo-

sure on food- and codeine-maintained responding(monkeys), 105

effects of naltrexone on narcoticdiscrimination (pigeons,

monkeys), 652

effects of thiamine deficiency(rats), 537

intravenous self-administration

of drugs during food depni-vation and satiation (rats),241

pentobarbital-reinforced, roleof pentobarbital drinking(monkeys), 114

three-choice drug discrimina-tion (rats), 254

Belinsky, S. A., see Reinke, L. A.,863

Benzolamide, effect on sodium en-try to cerebrospinal fluid

(rats),51[3H]Benzoyl-phenylalanyl-alanyl-

proline, metabolism by pul-monary angiotensin convert-ing enzyme in vivo, effects of

bradykinin, SQ 14225 oracute hypoxia (rabbits, dogs),263

Berkowitz, A. L., see Patrick, R.L., 686

Biotransformation, of methylmer-

curic chloride, influence ofchelating agents (rats), 500

Bircher, J., see Zysset, T., 198Bittar, E. E., see Helmer, P., 248Blake, D. A., see Spielberg, S. P.,

386

Blass, J. P., see Barclay, L. L., 537Bleomycin, effect on pulmonary

amine uptake (rabbits), 524Blood flow

coronary, in myocardial isch-emia, comparison of calciumantagonists (dogs), 20

renal, effects of lergotrile(dogs), 660

Blood pressureeffects of lergotrile (dogs), 660effects of prazosin (rats), 397increase, effects of interaction

between angiotensin andopioid peptides (rats), 619

Bohr, D. F., see Webb, R. C., 26Bone, resorption, parathyroid

hormone-stimulated, inhibi-

tion by ouabain (mice), 586

Borow, K. M., Spann, J. F. andCoulson, R. L.: The directmyocardial energetic re-

sponse to nitroglycerine in

the rabbit heart, 566

Bradykinin, effects on metabo-lism of [3H}benzoyl-phenyla-lanyl-alanyl-proline by pul-

monary angiotensin convert-

ing enzyme in vivo (rabbits,dogs), 263

Braincatecholamine content and up-

take, action of xylamine

(rats), 834

cerebral cortex, enhancementof y-aminobutynic acid inhi-bition by sodium valproate in

(rats),445cholinergic nerves in arteries of

(cats, rabbits), 544depletion and restoration of

synaptic plasticity by exoge-

nous catecholamines (kit-

tens, cats), 841

differences between mazindol

and homologs on biochemicaland behavioral responses(rats), 745

disposition of morphine in

(rats), 181

effects ofp-chloroamphetamineon locomotor activity andserotonin leveLs (rats), 738

effects of phencyclidine onturnover rate of acetylcholinein (rats), 733

measurement of imipramineand desmethylimipramine in

(rats), 461

potassium-induced release of

dopamine and norepineph-rine from, effects of catechol-amine uptake inhibitors(rats), 727

striatum, effects of amphet-amine on dopamine synthesisin (rats), 686

whole1 monoamines, effects ofreserpine (rats), 357

Branch, R. A., see James, R., 127Breese, G. R., see Lundberg, D.

B., 215

Brink, C., Duncan, P. G. andDouglas, J. S.: The responseand sensitivity to histamineof respiratory tissues from

normal and ovalbumin-sensi-tized guinea pigs: Effects of

cyclooxygenase and lipoxy-genase inhibition, 592

Brody, T. M., see Kim, D.-H., 559Brody, T. M., see Temma, K., 708

Brody, T. M., see Yamamoto, S.,

701

Bromobenzene, effect on drugmetabolism within liver lob-ule (rats), 127

2-Bromo-D-lysergic acid, diethyl-

amide bitartrate (BOL) dualactions on dorsal root poten-tials evoked by stimulation ofraphe nuclei (cats), 99

Bross, D. S., see Spielberg, S. P.,386

$-Bungarotoxin, cholinergic

blocking actions of (guineapigs, rabbits, rats, mice), 505

Bupropion, radioimmunoassayand pharmacokinetic profileof (dogs, rabbits, man, rats,mice), 602

Butcher, L. L., see Dudley, M. W.,834

Butz, R. F., Schroeder, D. H.,Welch, R M., Mehta, N. B.,Phillips, A. P. and Findlay, J.W. A.: Radioimmunoassayand pharmacokinetic proffleof bupropion in the dog, 602

Bylund, D. B.: Interactions ofneuroleptic metabolites withdopaminergic, alpha adre-nergic and muscarinic cholin-ergic receptors, 81

Ca�, inhibition of isoproterenolresponses in skeletal muscle(mice), 271

Cabbat, F. S., see Heikkila, R. E.,

745

Caffeine, effect on cardiac san-colemmal 5’-nucleotidase(rats), 489

Calcium-induced contraction of aortic

strips, effects of calmodulin

antagonists on (rabbits), 494

influx in aorta and mesentericarteries, inhibition by flunar-izine of (rats), 510

Calcium antagonists, comparisonon coronary blood flow inmyocardial ischemia (dogs),

20Calmodulin, antagonists, effects

on calcium-induced contrac-tion of aortic strips (rabbits),494

Canrenone, effect on Na�-K�-

adenosine triphosphatase, in-teraction with ouabain(guinea pigs), 784

Captopril, effect on nonenzymaticmethionine enkephalin mac-

tivation in ileum (guineapigs), 750

Caputy, A. J., Kim, Y. I. andSanders, D. B.: The neuro-muscular blocking effects of

therapeutic concentrations ofvarious antibiotics on normalrat skeletal muscle: A quan-titative comparison, 369

Carbamazepine to carbamaze-pine-10,11-epoxide pathway,

induction effect of phenobar-bital on (monkeys), 555

Carbendilhin, inactivation of to-bramycin, gentamicin, netil-micin and amikacin (man),345

Carbocromene, effects on myocar-dial oxygen consumption inisolated hearts (dogs), 306

Carbon tetrachloride, effect ondrug metabolism within liverlobule (rats), 127

Carbonic anhydrase inhibitors, ef-fect on sodium entry to cere-brospinal fluid (rats), 51

Carroll, M. E., France, C. P. andMeisch, R. A.: Intravenousself-administration of etoni-

tazene, cocaine and phency-clidine in rats during fooddeprivation and satiation, 241

Casu, M. and Gale, K.: Differen-tial effects of y-aminobutyricacid (GABA)-elevatingagents on the neuroleptic-in-duced activation of stniatal

tyrosine-hydroxylase: Evi-

dence that di-n-propylace-tate augments GABAergicneurotransmission, 177

Catecholamines (see also specificname)

content in brain, actions of xy-lamine on (rats), 834

effects on spinal sympathetic

reflexes (frogs), 170exogenous, intracortical spread

(kittens, cats), 841

hyperpolarization in superiorcervical ganglia, comparison

of receptors mediating (rab-bits),440

Catravas, J. D. and Gills, C. N.:Metabolism of [3H]ben.zoyl-phenylalanyl-alanyl-prolineby pulmonary angiotensinconverting enzyme in vivo:

Effects of bradykinin SQ14225 or acute hypoxia, 263

Catravas, J. D., Lazo, J. S. andGillis, C. N.: Biochemicalmarkers of bleomycin toxic-ity: Clearance of [‘4C]-5-hy-droxytryptamine and [3H}-norepinephnine by rabbitlung in vivo, 524

Catravas, J. D. and Waters, I. W.:Acute cocaine intoxication inthe conscious dog: Studies on

the mechanism of lethality,350

Ceftizoxime, renal excretion and

distribution (rats), 209

Cells, fat, perfused, growth hor-

mone stimulation of lipolysisand cyclic AMP in (rats), 15

Cerebrospinal fluid, sodium entryto, effect of carbonic anhy-

chase inhibitors and otherdrugs (rats), 51

Chelating agents, influence on dis-tribution and biotransforma-

tion of methylmercuric chlo-ride (rats), 500

Cheney, D. L., see Murray, T. F.,

733

Cheng, H. C., Gleason, E. M., Na-than, B. A., Lachmann, P. J.and Woodward, J. K.: Effectsof clonidine on gastric acidsecretion in the rat, 121

Cheng, K.-C., Lambert, J. J., Hen-derson, E. G., Smiowitz, H.and Epstein, P. M.: Postsyn-aptic inhibition of neuromus-cular transmission by trifluo-perazine, 44

Chikharev, V. N., see Gilmour, R.G., Jr., 390

Chinn, C., see Larson, A. A., 99Chiriquitoxin, new tool for

mapping ionic channels(frogs), 416

p-Chloroamphetamine, effects on

locomotor activity and sero-tonin levels (rats), 738

p-Chloromercuribenzyoate, iso-

lated inotropic action in iso-lated heart, influence ofmembrane stabilizing agents(guinea pigs), 768

p-Chloro-N-methylanilane de-

methylase, activity in liverand fetal tissues (man,chicks), 572

Chlorpromazine

INDEX 875

comparison of in vitro potency

at dopaminergic, alpha ad-renergic and muscarinic cho-

linergic receptor binding sites(sheep, rats), 81

pretreatment, effects on co-caine lethality (dogs), 350

Cho, A. K., see Dudley, M. W.,

834

Choline, high affinity uptake, incerebral arteries (cats, nab-bits), 544

Chromatography

gas-liquid, to measure levels of

morphine in plasma andbrain (rats), 181

high-performance liquid, andradioimmunoassay, determi-nation of fluphenazine, re-lated phenothiazine drugsand metabolites (rabbits,man), 36

Churchill, P., see Hatfield, M., 406

Ciguatoxin, actions in vas defer-ens (guinea pigs), 475

Clearancedrug, effect of obesity (man),

681

of [‘4C]-5-hydroxytryptamine

and [‘H]norepinephrine by

lung after bleomycin (rab-bits), 524

renal, of ceftizoxime (rats), 209Clomethiazole, effect of ethanol

on first-pass elimination of(rabbits), 198

Clonidineeffects on gastric acid secretion

(rats), 121effect on growth hormone se-

cretion (rats), 152Cocaine

effect on potassium-inducedrelease of dopamine and nor-epinephrine from brain

(rats), 727

intravenous self-administrationduring food deprivation and

satiation (rats), 241

poisoning (dogs), 350

Codeine

responding maintained by, ef-fects of naltrexone dose andhistory of naltrexone expo-

sure on (monkeys), 105transport mechanisms in ali-

mentary epithelia (rats), 285

Cohen, G., see Dembiec, D., 727Colburn, W. A., see Wurzburger,

R. J., 757Colchine, -induced supersensitiv-

ity in vas deferens, role of

changes in adrenergic nervesfor development of (rats), 516

Cole, A. E. and Shinnick-Gal-lagher, P.: Comparison of thereceptors mediating the cat-echolamine hyperpolaniza-

tion and slow inhibitory post-synaptic potential in sympa-thetic ganglia, 440

Colon, nicotine action on (rats),828

Cone, E. J., see Shannon, H. E.,379

Contractile force, in atria, effect

of aprindine on (frogs), 390Contraction, calcium-induced, of

aortic strips, effects of cal-modulin antagonists (nab-bits),494

Cooper, T. B., see Jason, K. M.,461

Copper, serum concentrationsand seizures, influence of D-

penicillamine (baboons), 138

Coulson, R. L., see Borow, K. M.,566

Cyclic AMP

in perifused fat cells, growthhormone stimulation of

(rats), 15levels, in isolated cardiac prep-

arations, effects of glucagon(rats, guinea pigs), 798

Cyclic AMP phosphodieterase,

inhibitors, effect on cardiacsarcolemmal 5’-nucleotidase(rats), 489

Cyclazocine, discrimination (rats),

254Cyclooxygenase, inhibition, ef-

fects on response and sensi-tivity to histamine of respi-

ratory tissues (guinea pigs),

592Cytotoxicity, of anticonvulsants,

role of arene oxides in (man,mice), 386

Dangman, K. H. and Hoffman, B.F.: In vivo and in vitro an-tiarrhythmic and arrhyth-mogenic effects of N-acetyl

procainamide, 851

Deamino-8 D-arglrnne vasopres-

sin, dose-dependent stimula-tion of renal prostaglandinsynthesis by (rats), 87

Deen, K., see Summy-Long, J. Y.,619, 630

Deficiency, thiamine, impairmentof behavior and acetylcholinemetabolism in (rats), 537

Delaage, M. A., see Puizillout, J.J., 791

Dembiec, D. and Cohen, G.:Potassium-induced release of

[3H]catecholamine frombrain: Effects of pre-exposureto catecholamine uptake in-hibitors, 727

Desmethylimipramine, effect onpotassium-induced release of

dopamine and norepineph-

rime from brain (rats), 727Desmond, P., see James, R., 127Dhalla, N. S., see Heyliger, C. E.,

489

Diabetes, hereditary, dose-depen-dent stimulation of renalprostaglandin synthesis bydeamino-8-D-arginine vase-

pressin (rats), 87

Diazepam

effect of obesity on distributionand clearance (man), 681

pretreatment, effects on co-caine lethality (dogs), 350

Dibutyryl-cyclic AMP, relaxation

of vascular smooth muscle by(rats, baboons, dogs, pigs,

cats), 26Dieu, D., see Godfraind, T., 510Digitalis, toxicity, effect of can-

renone (guinea pigs), 784

Digoxin, cardiac sensitivity, ef-fects of quinidine (guineapigs, rats), 559

Dihydromorphine, transportmechanisms in alimentary

epithelia (rats), 285Dilation, coronary, effects of tn-

mazosin (dogs), 3332,3-Dimercaptopropane- 1 -sulfo-

nate, influence on distribu-tion and biotransformation ofmethylmercuric chloride

(rats), 500Dimercaptosuccinic, influence on

distribution and biotransfor-mation of methylmercuric

chloride (rats), 500Diphenhydramine, effect on ino-

tropic action of p-chloromer-

cunibenzoate in isolated heart

(guinea pigs), 708

Dipyridamole, effect on cardiac

sarcolemmal 5’-nucleotidase(rats), 489

Disposition, of morphine in brain(rats), 181

Disobutamide, effects on electro-physiologic properties of car-

diac Purkinje fibers and pap-illary muscle (dogs), 549

Distributionand renal excretion of ceftizox-

ime (rats), 209

drug, effect of obesity (man),681

of methylmercuric chloride, in-fluence of chelating agents(rats), 500

Dita, effect on potassium-inducedrelease of dopamine and nor-epinephrine from brain

(rats), 727Divoll, M., see Abernethy, D. R.,

681

Dohrmann, M. L., Harrell, F. E.,

Jr. and Strauss, H. C.: Theeffects of disobutamide onelectrophysiologic properties

of canine cardiac Purkinje fi-bers and papillary muscle,549

L-Dopa, striatal dopamine forma-tion from (rats), 189

Dopamine

agonists and antagonists, influ-ence on locomotor activity

after opioid receptor agonists(rats), 451

brain, effects of mazindol andhomologs (rats), 745

formation in stniatum after L-

dopa (rats), 189in brain and small intestine, ef-

fects of reserpine (rats), 357receptor, presynaptic, stimula-

tion in cardiovascular actionsof lergotrile (dogs), 660

release from brain induced bypotassium, effects of cate-cholamine uptake inhibitors(rats), 727

synthesis in brain striatum, ef-

fects of amphetamine (rats),686

Douglas, J. S., see Brink, C., 592Doyle, A. S., see Vogh, B. P., 51Dubocovich, M. L., see Mas-

singham, R., 467Duckles, S. P.: Evidence for a

functional cholinergic inner-vation of cerebral arteries,544

Dudley, M. W., Butcher, L. L.,Kammerer, R. C. and Cho, A.K. The actions of xylamine

on central noradrenergic neu-rons, 834

Dun, N. J. and Karczmar, A. G.:Evidence for a presynapticinhibitory action of 5-hy-

droxytryptamine in a mam-

malian sympathetic ganglion,714

Duncan, P. G., see Brink, C., 592Dustman, R. E., see Snyder, E.

W.,299

Dyphylline, elimination in ure-mia, pharmacokinetics of(man), 340

Edema, paw, carrageenan-in-duced influence of dietaryprotein deficiency on sup-

pressant activity of anti-in-flammatory agents in (rats),

776

Eells, J. T., Makar, A. B., Noker,P. E. and Tephly, T. R.:Methanol poisoning and for-mate oxidation in nitrous ox-ide-treated rats, 57

Electrolytes, in urine, central ef-

fects of morphine, levor-phanol, methadone and en-dorphins (rats), 579

Electrophysiologic properties, of

cardiac Purkinje fibers andpapillary muscle, effects ofdisobutamide (dogs), 549

Electrophysiological effects, of N-

acetyl procainamide in car-diac tissues (dogs), 851

Elimination

of dyphylline in uremia, phar-macokinetics (man), 340

first-pass, of clomethiazole, ef-fect of ethanol (rabbits), 198

f3-Endorphin

central effects on urine volumeand electrolytes (rats), 579

inhibition of central actions ofangiotensin by (rats), 619

Enkephalin-analog, stimulation ofpulmonary J receptors by

(rats), 228Enkephalins

Leu5 and Met5, inhibition ofcentral actions of angiotensinby (rats), 619

met, nonenzymatic inactivationin ileum, effect of captopriland ascorbic acid on (guineapigs), 750

Enzymes, y-glutamyl cycle, in fe-tel liver (man), 697

Epilepsyinfluence of D-penicillamine on

seizure activity and trace

INDEX 877

turn after L-dopa administra-

tion, 189Heikkila, R. E., Cabbat, F. S.,

Manzino, L., Babington, R.G. and Houlihan, W. J.: Un-expected differences betweenmazindol and its homologs on

biochemical and behavioralresponses, 745

Helmer, P., Rusy, B. and Bittar,E. E.: Sensitivity to halo-thane of the sodium efflux insingle barnacle muscle fibers,

248

Henderson, E. G., see Cheng, K.-C., 44

Henningfield, J. E., see Meisch, R.A., 114

Herling, S.: Effects of naltrexone

dose and history of naltrex-one exposure on food- andcocaine-maintained respond-ing in rhesus monkeys, 105

Herling, S., see Valentino, R. J.,

652

Heyliger, C. E., Panagia, V. andDhalla, N. S.: Effect of cyclicAMP phosphodiesterase in-hibitors on cardiac sarcolem-

ma! 5’-nucleotidase, 489Hidaka, H., see Kanamori, M., 494

Hingston, S. J., see La Morte, W.

W., 638Histamine

H- and H2-receptors in gall-bladder, pH-dependent activ-ity (guinea pigs), 638

in vitro release from basophils,inhibition by zinc (man), 292

response and sensitivity of res-

piratory tissues to, effects of

cyclooxygenase and lipoxy-genase inhibition (guinea

pigs), 592Hoffman, B. F., see Dangman, K.

H., 851Holtzman, S. G., see White, J. M.,

254

Horwitz, J., see Lucot, J. B., 738Houlihan, W. J., see Heikkila, R.

E., 745

Huidobro, F., see Huidobro-Toro,J. P., 579

Huidobro-Toro, J. P. and Hui-dobro, F.: Central effects ofmorphine, levorphanol, (-)-

methadone and the opioid-like peptides /3-endorphinand D-alanine2-methiOflineenkephalinamide on urine

volume outflow and electro-lytes, 579

Hyaluronidase, effect on resist-

ance and transport after cor-onary flow reduction (dogs),62

Hydralozine, effect in arteries andveins (man), 204

6-Hydroxydopamine, effects on

disposition of norepinephrine

in aorta (rabbits), 162

5-Hydroxyindoleacetic acid, ra-

dioimmunoassay, use of iodi-

nated derivative (rabbits),791

5-Hydroxytryptamine (see also

Serotonin)inhibition of acetylcholine

release in sympathetic gan-

glion by (rabbits), 714[‘4C]-5-Hydroxytryptamine, clear-

ance by lung after bleomycin(rabbits), 524

6-Hydroxytryptamine, endoge-nous, intracortical spread(kittens, cats), 841

5-Hydroxytryptophan, effect on

growth hormone secretion

(rats), 152Hypertension, tolerance to pra-

zocin in, involvement ofrenin-angiotensin system

(rats), 397Hypersensitivity reactions, in vi-

tro, cardiac, thromboxaneand prostacyclin release dur-ing (guinea pigs), 157

Hypoxia, acute, effects on metab-

olism of [3H]benzoyl-pheny-

lalanyl-alanyl-proline by pul-monary angiotensin convert-ing enzyme in vivo (rabbits,dogs), 263

Ileum

effect of captopril and ascorbicacid on nonenzymatic methi-onine enkephalin inactiva-tion in (guinea pigs), 750

isolated, effect of antimorphineantibodies on antagonist-pre-

cipitated contracture in(guinea pigs), 820

Imipramine, prenatal exposure,effect on early behavioral de-velopment and beta adrener-

gic receptors (rats), 461

Inotropic actionof p-chloromercuribenzoate in

isolated heart, influence ofmembrane stabilizing agent(guinea pigs), 708

ofisoproterenol in heart (mice),314

of ouabain in heart (guineapigs), 701

Intestineformation of 1-thiocarbamoyl-

2-imidazolidinone from niri-

dazole in (mice), 363small, monoamines, effects of

reserpine (rats), 357small, transit, effects of reser-

pine on (rats), 357Inturnisi, C. E., see Ling, G. S. F.,

147

Ionic channels, mapping, by chi-niquitoxin (frogs), 416

Isoproterenolcomparison with glucagon on

cyclic AMP levels in isolatedcardiac preparations (rats,guinea pigs), 798

inotropic action in heart (mice),314

relaxation of vascular smooth

muscle by (rats, baboons,dogs, pigs, cats), 26

responses in skeletal muscle,

Ca� inhibition of (mice), 271-stimulated phosphorylase a

formation in heart (mice),

326

Itakura, T. see Kasamatsu, T., 841

Iwamoto, E. T.: Locomotor activ-

ity and antinociception after

putative mu, kappa andsigma opioid receptor ago-nists in the rat: Influence ofdopaminergic agonists andantagonists, 451

Iwasa, J., see Masutani, T., 812

Jackson, M. J.: Transport mech-

anisms for narcotics and nan-

cotic antagonists in alimen-

tary epithelia, 285

James, H., Desmond, P., K#{252}pfer,

A., Schenker, S. and Branch,H. A.: The differential locali-zation of various drug metab-

olizing systems within the rat

liver lobule as determined bythe hepatotoxins allyl alco-

hol, carbon tetrachloride andbromobenzene, 127

Jason, K. M., Cooper, T. B. andFriedman, E.: Prenatal expo-sure to imipramine alters

early behavioral develop-ment and beta adrenergic re-ceptors in rats, 461

Jobe, P. C., see Stewart, J. J., 357

Jolly, S. R., Hardman, H. F. and

Gross, G. J.: Comparison oftwo dihydropynidine calcium

antagonists on coronary col-

lateral blood flow in acutemyocardial ischemia, 20

Jonsson, G., see Kasamatsu, T.,841

Jurevichus, J. A., see Gilmour, R.G., Jr., 390

Kammerer, R. C., see Dudley, M.W., 834

Kanamori, M., Naka, M., Asano,M. and Hidaka, H.: Effects ofN (6-aminohexyl) - 5 - chloro-1 - aphthalenesulfonamideand other calmodulin antag-onists (calmodulin interact-

ing agents) on calcium-in-

duced contraction of rabbitaortic strips, 494

Kao, C. Y., Yeoh, P. N., Goldfin-ger, M. D., Fuhrman, F. A.

and Mosher, H. S.: Chiniqui-

toxin, a new tool for mappingionic channels, 416

Kaplan, H. R., see Smith, R. D.,

397

Karasawa, T., see Masuda, Y., 805

Karczmar, A. G., see Dun, N. J.,714

Karras, P. J. and North, R. A.:

Acute and chronic effects ofopiates on single neurons of

the myenteric plexis, 70

Kasamatsu, T., Itakura, T. andJonsson, G.: Intracorticalspread of exogenous cate-

cholamines: Effective con-centration for modifying con-tical plasticity, 841

Kasuya, Y., see Saito, A., 516Kauffman, F. C., see Reinke, L.

A., 863

Keil, L. C., see Summy-Long, J.

619, 630

Kelly, M., see Gross, S. H., 271

Kidney

clearance of ceftizoxime (rats),

209

function, effects of prostaglan-

din F�k (dogs), 674

prostaglandin synthesis, dose-dependent stimulation by

deamino-8-D-arginine vase-

pressin (rat.s), 87

vascular and tubular, effects ofvanadate (rats), 406

Killam, E. K., see Alley, M. C.,138

Killian, A. K., Schuster, C. R. andWainer, B. H.: Effect of anti-morphine antibodies on an invitro correlate of antagonist-precipitated opiate absti-

nence, 820Kim, D.-H., Akera, T. and Brody,

T. M.: Effects of quinidine onthe cardiac-glycoside sensi-tivity of guinea-pig and rat

heart, 559Kim, D.-H., see Yamamoto, S.,

701

Kim, Y. I., see Caputy, A. J., 369Kinetics

of reaction top-chloro-N-meth-ylaniine demethylase in liverand fetal tissues (man,chicks), 572

plasma, of phenylethanolamineand N-methyl phenyletha-nolamine (dogs), 379

Kliner, D. J., see Meisch, R. A.,114

Kondo, H., see Temma, K., 708

Krieger, A. J., see Sapru, H. N.,228

Krieger, N. S. and Tashjian, A.H., Jr.: Inhibition by ouabainof parathyroid hormone-stimulated bone resorption,586

Krishnaswamy, K., see Rollins,

D., 697

Kuhn, C. M. and Schanberg, S.M.: Maturation of centralnervous system control ofgrowth hormone secretion inrats, 152

K#{252}pfer,A., see James, R., 127Kuramatsu, I., see Miura, A., 505

Lachmann, P. J., see Cheng, H.C., 121

Lambert, J. J., see Cheng, K.-C.,44

La Monte, W. W., Hingston, S. J.

and Wise, W. E.: pH-depen-dent activity of H1- and H�-histamine receptors inguinea-pig gallbladder, 638

Langer, S. Z., see Massingham, R.,

467

Larson, A. A., Chinn, C., Proudflt,H. K. and Anderson, E. G.:Dual actions of lysergic aciddiethylamide tartrate (LSD),

2-bromo-D-lysergic acid di-

ethylamide bitartrate (BOL)and methysergide on dorsal

878 INDEX

root potentials evoked bystimulation of raphe nuclei,99

Larsson, A., see Rollins, D., 697Lazo, J. S., see Catravas, C. D.,

524Lee, C-S. C., Wang, L H., Ma-

jeske, B. L. and Marbury, T.C.: Pharmacokinetics of dy-phylline elimination byuremic patients, 340

Lee, C.-Y., see Miura, A., 505Leff, A. R. and Munoz, N. M.:

Evidence for two subtypes ofalpha adrenergic receptors incanine airway smooth mus-cle, 530

Lergotrile, cardiovascular actions,stimulation of presynaptic

dopamine receptors in (dogs),660

Levi, R., see Allan, G., 157

Levin, J. A. and Wilson, S. E.: Theeffects of 6-hydroxydopa-mine on the disposition ofnorepinephrine in the rabbit

aorta, 162Levorphanol, central effects on

urine volume and electrolytes(rats), 579

Levy, R. H., see Patel, I. H., 555Lichtenstein, L. M., see Marone,

G., 292Lieber, C. S., see Matsuzaki, S.,

133Lieber, C. S., see Vittek, J., 411

Ling, G., see Nozaki, M., 666TAng, G. S. F., Umans, J. G. and

Inturrisi, C. E.: Methadone:Radioimmunoassay andpharmacokinetics in the rat,147

IApe, S. and Moulds, R. F. W.: Invitro differences between hu-man arteries and veins intheir responses to hydrala-zine, 204

Lipolysis, in perfused fat cells,growth hormone stimulationof (rats), 15

Lipoxygenase, inhibition, effectson response and sensitivity tohistamine of respiratory tin-sues (guinea pigs), 592

Liverp-chloro-N-methylanilane de-

methylase activity in (man,chicks), 572

effect of ethanol on testoster-one-5a-reductase in (rats),411

ethanol oxidation at highethanol concentrations, roleof alcohol dehydrogenase(rats), 133

fetal, glutathione and y-gluta-myl cycle enzymes in (man),697

influence of dietary protein de-ficiency on lysosome stabiliz-ing activity of anti-inflam-matory agents in (rats), 776

lobule, drug metabolism, effects

of hepatoxins (rats), 127perfused, conjugation of p-ni-

trophenol in (rats), 863Locomotor activity

after opioid receptor agonists,influence of dopaminergic ag-

onists and antagonists (rats),451

effects ofp-chloroamphetamine(rats), 738

Lokhandwala, M. F., see Barrett,RJ.,660

Long, K. J., see Sengupta, K., 15Lucot, J. B., Horwitz, J. and Sei-

dent, L. S.: The effects of p-chloroamphetamine admin-istration on locomotor activ-ity and serotonin in neonatal

and adult rats, 738

Lundberg, D. B., Breese, G. R.and Mueller, R. A.: Amino-phylline may stimulate res-piration in rats by activationof dopaminergic receptors,215

Lungangiotensin-converting enzyme,,

effects of bradykinin, SQ14225 or acute hypoxia onmetabolism of [3H]benzoyl-phenylalanyl-alanyl-proline

in vivo by (rabbits, dogs), 263effect of bleomycin on amine

uptake by (rabbits), 524sensory receptors, stimulation

by enkephalin-analog (rats),228

Luttinger, D., see Osbahar, A. J.

III, 645Lymphocytes, cytotoxicity in, an-

ticonvulsant role of arene ox-ides (man, mice), 386

Lysergic acid diethylamide tar-trate (LSD), dual actions,on dorsal root potentialsevoked by stimulation ofraphe nuclei (cats), 99

Macho, P. and Vatner, S. F.: Ef-fects and mechanism of ac-tion of tnimazosin on coro-nary and left ventricular dy-namics in conscious dogs, 333

MacLeod, K. M., Rodgers, R Land McNeil!, J. H.: Charac-terization of glucagon-in-duced changes in rate, con-tractiity and cyclic AMPlevels in isolated cardiac

preparations of the rat and

guinea pig, 798

Maes, R. A. A., see Plomp, G. J.J., 181

Majeske, B. L, see Lee, C.-S. C.,340

Makar, A. B., see Bells, J. T., 57

Malcolm, R. D. and Alkana, R L:

Temperature dependence ofethanol depression in mice,770

Manzino, L, see Heikkila, R E.,745

Marbury, T. C., see Lee, C.-S. C.,340

Marcum, E. A., see Wurzburger,

R. J., 757Marone, G., Findlay, S. R and

Lichtenstein, L. M.: Modula-tion of histamine release fromhuman basophils in vitro byphysiological concentrations

of zinc, 292Mason, G. A., see Osbahr, A. J.

III, 645

Massingham, R., Dubocovich, M.L, Shepperson N. B. andLanger, S. Z.: In vivo selectiv-

ity of prazosin but not of

WB41O1 for postsynaptic al-p/ia-i adrenoceptors, 467

Masuda, Y., Utsui, Y., Shiraishi,Y., Karasawa, T., Yoshida, K.and Shimizu, M.: Evidencefor a synergistic interactionbetween phenytoin and phe-nobarbital in experimentalanimals, 805

Masutani, T., Seyama, I., Nara-hashi, T. and Iwasa, J.: Struc-ture-activity relationship forgrayanotoxin derivatives infrog skeletal muscle, 812

Mather, L. E., Gourlay, G. K.,Parkin, K. S. and Roberts, J.

..‘ G.: Pharmacodynamics ofminaxolone, a new steroidalanesthetic, 481

Matsuzaki, S., Gordon, E. and Lie-

ber, C. S.: Increased alcoholdehydrogenase independentethanol oxidation at high

ethanol concentrations in iso-lated rat hepatocytes: The ef-fect of chronic ethanol feed-ing, 133

Mazindol

and homologs, different effectson biochemical and behav-

ioral responses (rats), 745effect on potassium-induced

release of dopamine and nor-epinephnine from brain(rats), 727

McEnlane, B., see Tam, Y. K., 764

McNeill, J. H., see MacLeod, K.

M., 798

Mecillinam, inactivation of tobra-mycin, gentamicin, netilmicinand amikacin (man), 345

Medzihradsky, F., see Valentino,

H. J., 652Meht.a, N. B., see Butz, R. F., 602Meiach, R. A., see Carroll, M. E.,

241Meisch, H. A., Kliner, D. J. and

Henningfield, J. E.: Pento-barbital drinking by rhesusmonkeys: Establishment andmaintenance of pentobarbi-

tel-reinforced behavior, 114Melamed, E., see Hefti, F., 189Mellits, E. D., see Spielberg, S. P.,

386

Membrane currents, in peripheral

nerve, effects ofgallamine tri-ethiodide (rats, frogs), 719

Mephenytoin, cytotoxicity, role ofarene oxides (man, mice), 386

Merz, H., see Valentino, R. J., 652Metabolism

acetylcholine, in thiamine defi-ciency, impairment (rats),

537

arachidonic acid, relation tohistamine-induced contrac-

tion in airway muscle (guineapigs), 592

drug, in obesity (man), 681drug, within liver lobule, effects

of hepatoxins (rats), 127ethanol, after chronic ethanol

consumption, role of alcoholdehydrogenase (rats), 133

of [3H]benzoyl-phenylalanyl-alanyl-proline by pulmonaryangiotensin converting en-zyme in vivo, effects of brady-kinin, SQ 14225 or acute hy-poxia (rabbits, dogs), 263

of niridazole in intestine (mice),363

Metabolites

neuroleptic, interactions withdopaminergic, alpha adre-

nergic and muscaninic cholin-ergic receptors (sheep, rats),81

phenothiazine, determination

by combined high-perform-ance liquid chromatographyand radioimmunoassay (rab-bits, man), 36

Methadoneinteraction with theophylline,

effect upon respiration and

ventilation (dogs), 278radioimmunoassay and phar-

macokinetics (rats), 147

transport mechanisms in ali-mentary epithelia (rats), 285

(-)-Methadone, central effects onurine volume and electrolytes(rats), 579

Methanol, poisoning in nitrousoxide treatment (rats), 57

Methazolamide, effect on sodium

entry to cerebrospinal fluid(rats), 51

Methylmercunic chloride, distri-bution and biotransforma-tion, influence of chelatingagents on (rats), 500

N-Methyl phenylethanolamine,physiologic effects andplasma kinetics of (dogs), 379

Methylxanthines (see specific

drug)Methysergide, dual actions on

dorsal root potentials evokedby stimulation of raphe nu-clei (cats), 99

Metoclopramide, dose-dependentpharmacokinetics of (rats),764

Mezlocillin, inactivation of tobra-mycin, gentamicin, retilmicinand amikacin (man), 345

Miller, D. D., see Fuder, H, 1Miller, R. L, see Wurzburger, R.

J., 757Minaxolone, new steroidal anes-

thetic, pharmacodynamics of(sheep), 481

Miura, A., Muramatsu, I., Fuji-wara, M., Hayashi, K. andLee, C.-Y., Species and re-gional differences in cholin-

880 INDEX

Oxidationformate, in nitrous oxide treat-

ment (rats), 57ethanol, at high ethanol con-

centrations in liver, role of

alcohol dehydrogenase (rats),133

Oxygen, myocardial consumption,effects of carbocromene(dog), 306

Palatini, P., see Finotti, P., 784

Panagia, V., see Heyliger, C. E.,489

Pancuronium, pretreatment, ef-fects on cocaine lethality(dogs), 350

Papaverine, effect on cardiacsarcolemmal 5’-nucleotidase(rats), 489

Parathyroid-hormone, -stimu-lated bone resorption, inhi-bition by ouabain (mice), 586

Parkin, K. S., see Mather, L. E.,481

Patel, I. H., Wedlund, P. andLevy, R. H.: Induction effectof phenobarbital on the car-bamazepine to carbamaze-pine-10,11-epoxide pathwayin rhesus monkeys, 555

Patil, P. N., see Fuder, H., 1

Patrick, R. L., Berkowitz, A. L.and Regenstein, A. C.: Effectsof in vivo amphetamine ad-

ministration on dopamine

synthesis regulation in rat

brain striatal synaptosomes,686

D-Peniclllamine, influence upon

seizure activity and tracemetal status (baboons), 138

Penicillins, semisynthetic (see

specific drug)Pentobarbita!

and phencyclidine, on fixed-in-terval performance (mon-keys), 61

drinking, role in pentobarbital-reinforced behavior (mon-keys), 114

effect on growth hormone so-cretion (rats), 152

enhancement of spike fre-quency adaption in neuronsby (sea hares), 222

Petschke, T., see Rilkind A. B.,

572

pH, dependent activity of H1- andH2-histamine receptors ingallbladder (guinea pigs), 638

Pharmacodynamics, of minaxo-lone (sheep), 481

Pharmacokinetics (see also kinet-ics)

dose-dependent, of metoclo-pramide (rats), 764

of bupropion (dogs, rabbits,man, rats, mice), 602

of carbamazepine, effects ofphenobarbita! (monkeys),

555of dyphylline elimination in

uremia (man), 340of methadone (rats), 147

Phenacemide, cytotoxicity, role of

arene oxides (man, mice), 386Phencyclidine

and pentobarbital, effects onfixed-interval performance

(monkeys), 611effect on turnover rate of ace-

tylcholine in brain (rats), 733intravenous self-administration

during flood deprivation and

satiation (rats), 241Phenobarbital

cytotoxicity, role of arene ox-ides (man, mice), 386

effect on inotropic action of p-chloromercuribenzoate inisolated heart (guinea pigs),708

enhancement of spike fre-quency adaption in neuronsby (sea hares), 222

induction effect on carbamaze-pine to carbamazepine-10,ii-epoxide pathway (monkeys),555

synergistic interaction with

phenytoin (mice, rabbits),805

Phenothiazines, determination by

combined high-performanceliquid chromatography andradioimmunoassay (rabbits,man), 36

Phenylethanolamine, physiologic

effects and plasma kinetics of

(dogs), 379Phenytoin

cytotoxicity, role of arene ox-ides (man, mice), 386

synergistic interaction withphenobarbital (mice, rab-bits), 805

Phillips, A. P., see Butz, R. F., 602Phosphorylase a, isoproterenol-

stimulated formation in heart(mice), 326

Pickering, L. K. and Rutherford,I.: Effect of concentrationand time upon inactivation oftobramycin, gentamycin, ne-tilmicin and amikacin byazlocilhin, carbenicillin, mecil-

linam, mezlocillin and piper-acillin, 345

Pimozide, pretreatment, effectson cocaine lethality (dogs),350

Piperacillin, inactivation of tobra-

mycin, gentamicin, netilmicin

and amikacin (man), 345

Plans-Bohne, F.: The influence ofchelating agents on the dis-tnibution and biotransforma-tion of methylmercuric chlo-ride in rats, 500

Plasma

concentrations of anti-inflam-matory agents, influence ofdietary protein deficiency(rats), 776

kinetics, of phenylethanola-mine and N-methyl phenyl-ethanolamine (dog), 379

Plomp, G. J. J., Maes, R. A. A.and van Rhee, J. M.: Dispo-sition of morphine in ratbrain: Relationship to biolog-

ical activity, 181

Poisoning

cocaine (dogs), 350methanol, in nitrous oxide

treatment (rats), 57

Potassium -induced release of do-pamine and norepinephrinefrom brain, effects of cate-cholamine uptake inhibitors(rats), 727

Potassium channel, blockage bychiniquitoxin (frogs), 416

Potentialaction, in skeletal muscle, effect

of grayanotoxin (frogs), 8i2dorsal root, evoked by stimula-

tion of raphe nuclei, dual ac-tions ofserotonin antagonists(cats), 99

membrane, of saphenous an-tery, effect of reserpine (rab-bits), 430

slow inhibitory postsynaptic, insuperior cervical ganglia, me-diation by catecholamine re-ceptors (rabbits), 440

transmembrane, effects of N-

acetyl procainamide (dogs),851

Prange, A. J., Jr., see Osbahr, A.J. III, 645

Prazosinalpha-i adrenoceptor selectiv-

ity of (cats, dogs), 467tolerance to, involvement of

renin-angiotensin system

(rats), 397Price, J. D. E., see Tam, Y. K.,

764

Procainamide, effect on inotropicaction of p-ch!oromercuri-benzoate in isolated heart

(guinea pigs), 708Propranolol

effect on inotropic action of p-

chloromercunibenzoate inisolated heart (guinea pigs),708

pretreatment, effects on co-caine lethality (dogs), 350

Prostacyclin, release from heartduring hypersensitivity reac-tions in vitro (guinea pigs),157

Prostaglandin, renal synthesis,dose-dependent stimulation

by deamino-8-o-arginine va-sopressin (rats), 87

Prostaglandin F�,,, effects on renalfunction (dogs), 674

Prostate, effect of ethanol on tes-tosterone-5a-reductase in(rats), 411

Protamine, effect on resistanceand transport after coronaryflow reduction (dogs), 62

Protein, deficiency, dietary, influ-ence on lysosome stabilizingand paw edema suppressantactivity of anti-inflammatoryagents (rats), 776

Proudfit, H. K., see Larson, A. A.,

99

Puizillout, J. J. and Delaage, M.A.: Radioimmunoassay of 5-hydroxyindole acetic acid us-

ing an iodinated derivative,

791

Purkinje fiberscardiac, effects of disobutamide

on electrophysiologic prop-erties of (dogs), 549

isolated, effects ofN-acetyl pro-

cainamide (dogs), 851

Quinidine, effects on cardiac gly-coside sensitivity (guineapigs, rats), 559

Radioimmunoassayand high-performance liquid

chromatography, determina-

tion of fluphenazine, relatedphenothiazine drugs and me-

tabolites (rabbits, man), 36

for tetracycline (rabbits, dogs),

10

of bupropion (dogs, rabbits,man, rats, mice), 602

of halopenidol (rabbits, rats),

757of 5-hydroxyindoleacetic acid,

use of iodinated derivative

(rabbits), 791

of methadone (rats), 147

to measure levels of morphine

in plasma and brain (rats),181

Rane, A., see Rollins, D., 697Rappaport, S. C., see Vittek, J.,

411

Receptors

alpha adrenergic, blockade by

tnimazosin (dogs), 333alpha adrenergic, interactions

with neuroleptic metabolites(sheep, rats), 81

alpha adrenergic, postsynaptic,

differentiation by yohimbine

(rats), 235

beta adrenergic, early develop-

ment, effect of prenatal ex-posure to imipramine (rats),461

catecholamine, mediating cate-

cholamine hyperpolarizationand slow inhibitory postsyn-aptic potential in superior

cervical ganglia (rabbits), 440dopamine, presynaptic, stimu-

lation in cardiovascular ac-tions of lergotrile (dogs), 660

dopaminergic, aminophylline-

induced stimulation of respi-ration by activation of (rats),215

dopaminergic, interactions withneuroleptic metabolites(sheep, rats), 81

Hr and H2-histamine, pH-de-pendent activity in gallblad-der (guinea pigs), 638

muscaninic cholinergic, interac-tions with neuroleptic me-

tabolites (sheep, rats), 81nicotinic, in colon (rat), 828opiate, blockade, effect on an-

giotensin-induced drinkingand vasopressin release(rats), 630

opioid, agonists, locomotor ac-tivity and antinociception

after (rats), 451

pulmonary J, stimulation byenkephalin-analog (rats), 228

Regenstein, A. C., see Patrick, R.L., 686

Reinke, L. A., Belinsky, S. A., Ev-ans, H. K., Kauffman, F. C.

enkephalin-analog, 228

Sanders, D. B., see Caputy, A. J.,369

Schanberg, S. M., see Kuhn, C.M., 152

Schauf, C. L., see Smith, K. J., 719

Schenker, S., see James, R., 127

in amphibian and mamma-

han peripheral nerve, 719Smith, R. D., Tessman, D. K. and

Kaplan, H. R.: Acute toler-ance to prazosin in conscioushypertensive rats: Involve-

ment ofthe renin-angiotensm

nophylline-induced (rats),215

Stomachperfused, effects of clonidine on

gastric acid secretion in(rats), 121

steric aspects of alpha adreno-

and Thurman, R. G.: Conju-

gation ofp-nitrophenol in theperfused rat liver: The effectof substrate concentrationand carbohydrate reserves,

Schlehuber, C., see Snyder, E. W.,299

Schlitt, S. C., see Olsen, G. D., 278

Scholtholt, J., see Fiedler, V. B.,306

system, 397

Smooth muscle (see Muscle,smooth)

Snyder, E. W., Dustman, R. E.and Schlehuber, C.: Nalox-

receptors of (rabbit), 1Stone, H. L., see Gwirtz, P. A., 92Strandhoy, J. W., see Zook, T. E.,

674Strauss, H. C., see Dohrmann, M.

863

Renin-angiotensin system, in-volvement in tolerance to

Schroeder, D. H., see Butz, R. F.,602

Schuster, C. R., see Killian, A. K.,

one epileptogenesis in mon-keys, 299

Sodium

L., 549Stniatum

brain, effects of amphetamine

prazosin (rats), 397 820 efflux in muscle fibers, effect of on dopamine synthesis in

Reserpineeffects on monoamines and in-

testinal transit (rats), 357

Secretiongastric acid, effects of clonidine

(rats), 121

halothane (barnacle), 248

entry to cerebrospinal fluid, ef-fect ofcarbonic anhydrase in-

(rats), 686haloperidol levels, radioimmu-

noassay for (rabbits, rats),

effect on sensitivity and mem-brane potential of saphenousartery (rabbits), 430

Respiration

aminophylline-induced stimu-lation by activation of dopa-

minergic receptors (rats), 215effect of theophylline and

methadone interaction upon

of growth hormone, maturation

of central nervous systemcontrol of (rats), 152

Seident, L. S., see Lucot, J. B., 738

Seizuresand trace metal status, influ-

ence of D-penidillamine (ba-boons), 138

naloxone (monkeys), 299

hibitors and other drugs on

(rats), 51

Sodium channelsblockage by

(frogs), 416grayanotoxin

(frogs), 812Sodium-potassium pump, sites in

smooth muscle (guinea pigs),

757site of dopamine formation

after L-dopa (rats), 189tyrosine hydroxylase, effects of

y-aminobutyric acid-elevat-ing agents on neuroleptic-in-

duced activation of(rats), 177

Summy-Long, J. Y., Keil, L. C.,

Deen, K., Rosella, L. and(dogs), 278 Sengupta, K., Long, K. J. and Al- 692 Severs, W. B.: Endogenous

Rifkind, A. B. and Petschke, len, D. 0.: Growth hormone Sodium pump, electrogenic, ef- opioid peptide inhibition ofT.: p-Chloro-N-methylani- stimulation of lipolysis and fects of isoproterenol, dibu- the central actions of angio-line demethylase activity in cyclic AMP levels in perfused tyryl-cyclic AMP and theo- tensin, 619liver and extrahepatic tissues fat cells, 15 phylline (rats, baboons, dogs, Summy-Long, J. Y., Keil, L. C.,of the human fetus and in Sensitivity, of saphenous artery, pigs, cats), 26 Deen, K. and Severs, W. B.:chick embryo liver, 572 effect of reserpine (rabbits), Sodium valproate, enhancement Opiate regulation of angio-

Roberts, J. G., see Mather, L. E., 430 of y-aminobutynic acid inhi- tensin-induced drinking and481 Serotonin (see also 5-Hydroxy- bition (rats), 445 vasopressin release, 630

Robinson, R. L., see Abel, P. W., tryptamine) Southren, A. L., see Vittek, J., 411 Supersensitivity, colchicine-in-430 antagonists, dual actions on Spann, J. F., see Borow, K. M., duced, in vas deferens, role of

Rodgers, R. L., see MacLeod, K. dorsal root potentials evoked 566 changes in adrenergic nervesM., 798 by stimulation of raphe nu- Spector, S., see Wurzburger, R. J., for development of (rats), 516

Rollins, D., Larsson, A., Steen, B., clei (cats), 99 757Krishnaswamy, K., Hagen- brain, effects of mazindol and Spielberg, S. P., Gordon, G. B., Tachibana, K., see Ohizumi, Y.,

feldt, L., Mold#{233}us, P. and homologs (rats), 745 Blake, D. A., Mellits, E. D. 475

Rane, A.: Glutathione and y- in brain and small intestine, ef- and Bross, D. S.: Anticonvul- Tam, Y. K., Axelson, J. E., Mc-glutamyl cycle enzymes in fects of reserpine (rats), 357 sent toxicity in vitro: Possible Erlane, B., Ongley, R. and

human fetal liver, 697 levels, brain, effects of p-chlo- role of arene oxides, 386 Price, J. D. E.: Dose-depen-Romano, C.: Nicotine action on roamphetamine (rats), 738 Spike frequency adaption, in neu- dent pharmacokinetics of

rat colon, 828 Serum, haloperidol levels, ra- rons, barbiturate enhance- metoclopramide in rat: An ef-

Rosella, L., see Summy-Long, J. dioimmunoassay for (rabbits, ment of (sea hares), 222 fect of hemoperfusion?, 764

Y., 619 rats), 757 Spinal cord, sympathetic reflexes, Tashjian, A. H., Jr., see Knieger,

Rosenshtraukh, L. V., see Gil- Severs, W. B., see Summy-Long, catecholamine effects on N. S., 586

mour, R. G., Jr., 390 J. Y., 619, 630 (frogs), 170 Temma, K., Akera, T., Brody, T.Ruffolo, R. R., Jr., Waddell, J. E. Seyama, I., see Masutani, T., 812 Spleen, isolated perfused, selec- M. and Kondo, H.: Positive

and Yaden, E. L.: Postsyn- Shader, R. I., see Abernethy, D. tivities of prazocin and WB inotropic action of p-chlo-aptic alpha adrenergic recep- R., 681 4101 in (cats, dogs), 467 romercuribenzoate in iso-tor subtypes differentiated by Shannon, H. E., Cone, E. J. and SQ 14225, effects on metabolism lated guinea-pig heart: Influ-yohimbine in tissues from the Yousefnejad, D.: Physiologic of [3H]benzoyl-phenylalanyl- ence of membrane stabilizingrat. Existence of alpha-2 ad- effects and plasma kinetics of alanyl-proline by pulmonary agents, 708

renergic receptors in rat phenylethanolamine and its angiotensin converting en- Temperatureaorta, 235 N-methyl homolog in the zyme in vivo (rabbits, dogs), body, comparison of effects of

Rusy, B., see Helmer, P., 248 dog, 379 263 phenylethanolamine and N-Rutherford, I., see Pickering, L. Shepperson, N. B., see Mas- Steen, B., see Rollins, D., 697 methyl phenylethanolamine

K., 345 singham, R., 467Shibata, S., see Ohizumi, Y., 475

Stewart, J. J. and Jobe, P. C.:Effects of reserpine on mono-

on (dogs), 379dependence of ethanol depres-

Saito, A., Kasuya, Y. and Goto, Shimizu, M., see Masuda, Y., 805 amines and intestinal transit sion on (mice), 770K.: The role ofmorphological Shinnick-Gallagher, P., see Cole, in the rat, 357 Tephly, T. R., see Eells, J. T., 57and functional changes in ad- A. E., 440 Stimulation Terakawa, M., Tsuchiya, T., Wa-renergic nerves for the devel- Shinnick-Gallagher, P., see Un- electrical, of raphe nuclei, dual tanabe, Y. and Noguchi, H.:opment ofcolchicine-induced desser, E. K., 170 actions of serotonin antago- Renal excretion and distri-

supersensitivity in the rat vas Shiraishi, Y., see Masuda, Y., 805 mats on dorsal root potentials bution of ceftizoxime in rats,deferens, 516 Smiowitz, H., see Cheng, K.-C., evoked by (cats), 99 209

Saline, discrimination (rats), 254 44 of pulmonary J receptors by en- Tessman, D. K., see Smith, R. D.,Sapru, H. N., Willette, R. N. and Smith, K. J. and Schauf, C. L: kephalin-analog (rats), 228 397

Knieger, A. J.: Stimulation of Effects of gallamine triethio- of respiration by activation of Testosterone-5a-reductase, inpulmonary J receptors by an dide on membrane currents dopaminergic receptors, ami- oral tissues, effect of ethanol

INDEX 881

chiriquitoxin

binding site

882 INDEX

(rats), 411Tetracycline, radioimmunoassay

for (rabbits, dogs), 10Tetrodotoxin, comparison with

chinquitoxin (frogs), 416Theophylline

effect on cardiac sarcolemmal

5’-nucleotidase (rats), 489effect upon respiration and yen-

tilation, interaction withmethadone (dogs), 278

relaxation of vascular smoothmuscle by (rats, baboons,dogs, pigs, cats), 26

Thiamine, deficiency, impairmentof behavior and acetylcholinemetabolism in (rats), 537

1-Thiocarbamoyl-2-imidazolidi-

none, formation from nirida-zole in intestine (mice), 363

Thioridazine, comparison of in vi-

tro potency at dopaminergic,alpha adrenergic and mus-

carmnic cholinergic receptorbinding sites (sheep, rats), 81

Thromboxane, release from heartduring hypersensitivity reac-

tions in vitro (guinea pigs),157

Thurman, R. G., see Reinke, L.A., 863

Thyrotropin-releasing hormone,

antagonism of neurotensin-induced antinociception(mice), 645

Tissues

concentration of Na�,K�-aden-osine triphosphatase in heart(guinea pigs), 701

fetal, p-chloro-N-methylani-

lane demethylase activity in(man, chicks), 572

oral, effect of ethanol on testos-terone-5a-reductase in (rats),411

respiratory, response and son-sitivity to histamine, effectsof cyclooxygenase and lipoxy-genase inhibition (guineapigs), 592

Tobramycin, inactivation by azlo-dim, carbenicillin, mecilli-nam, mezlocillin and pipera-cillin (man), 345

Tolerance, to prazosin, involve-ment of renin-angiotensinsystem (rats), 397

Toxicity (see also cytotoxicity)bleomycin, biochemical mark-

ens of (rabbits), 524digitalis, effect of canrenone

(guinea pigs), 784

Trachea, alpha-i and alpha-2 ad-renergic receptors in (dogs),530

Tracy, J. W. and Webster, L. T.,Jr.: The formation of 1-thio-carbamoyl-2-imidazolidinone

from niridazole in mouse in-testine, 363

Transmembrane currents, inatria, effect of aprindine on(frogs), 390

Transmission

cholinergic, effects of/3-bungar-otoxin (guinea pigs, rabbits,rats, mice), 505

neuromuscular, in skeletal mus-cle, comparison of effects ofantibiotics on (rats), 369

neuromuscular, postsynaptic

inhibition by trifluoperazine

(chicks, frogs), 44synaptic, in sympathetic gan-

glia, effects of 5-hydroxytryp-tamine (rabbits), 714

Trifluoperazine, postsynaptic in-

hibition of neuromuscular

transmission by (chicks,

frogs), 44

Trimazosin, effects on coronaryand left ventricular dynamics(dogs), 333

Tsuchiya, T., see Terakawa, M.,209

Tyrosine hydroxylase, striate!, ef-fects of y-aminobutynic acid-elevating agents on neurolep-tic-induced activation of(rats), 177

Umans, J. G., see Ling, G. S. F.,147

Undesser, E. K., Schinnick-Gal-

lagher, P. and Gallagher, J.P.: Catecholamine modula-tion ofspinal sympathetic re-flexes, 170

Uptake, pulmonary amine, effectof bleomycin (rabbits), 524

Uremia, pharmacokinetics of dy-phylline elimination in(man), 340

Urine, volume and electrolytes,central effects of morphine,levorphanol, methadone andendorphins (rats), 579

Urquilla, P. R., see Abel, P. W.,430

Utsui, Y., see Masuda, Y., 805

Valentino, R. J., Herling, S.,Woods, J. H., Medzihradsky,F. and Merz, H.: Quaternarynaltrexone: Evidence for the

central mediation of discrim-inative stimulus effects of

narcotic agonists and antag-onists, 652

Vanadate, renal vascular and tu-bular effects of (rats), 406

van Rhee, J. M., see Plomp, G. J.J., 181

Van Vunakis, H., see Goldstein, S.

A., 36Varma, D. R., see Yue, T. L, 776

Vas deferensactions of ciguatoxin in (guinea

pigs), 475role of changes in adrenergic

nerves for development ofcolchicine-induced supersen-sitivity (rats), 516

smooth muscle, Na�-K�-pumpsite (guinea pigs), 692

Vasopressinrelease, angiotensin-induced,

opiate regulation of (rats),630

release, effects of interactionbetween angiotensin and

opioid peptides (rats), 619Vatner, S. F., see Macho, P., 333Veins, effect of hydralazine, in vi-

tro comparison to arteries(man), 204

Ventilation, effect of theophyllineand methadone interactionupon (dogs), 278

Ventricle, left, dynamics, effectsof tnimazosin (dogs), 333

Vittek, J., Gordon, G. G., South-ren, A. L, Rappaport, S. C.,Munnangi, P. R. and Lieber,C. S.: Effect of ethanol intakeon cellular regulation of tes-tosterone-5a-reductase in ratoral tissues, 411

Vogh, B. P. and Doyle, A. S.: Theeffect of carbonic anhydrase

inhibitors and other drugs on

sodium entry to cerebrospi-nal fluid, 51

Waddell, J. E., see Ruffolo, R. R.,Jr., 235

Wainer, B. H., see Killian, A. K.,

820Walker, L. A. and Fr#{246}lich,J. C.:

Dose-dependent stimulation

of renal prostaglandin syn-thesis by deamino-8-D-argi-nine vasopressin in rats withhereditary diabetes insipidus,87

Wang, L H., see Lee, C-S. C., 340Watanabe, Y., see Terakawa, M.,

209Waters, I. W., see Catravas, J. D.,

350WB41O1, alpha-i adrenoceptor

selectivity of (cats, dogs), 467

Webb, R C. and Bohr, D. F.: Re-laxation of vascular smoothmuscle by isoproterenol, di-

butyryl-cyclic AMP andtheophylline, 26

Webster, L. T., Jr., see Tracy, J.W., 363

Wedlund, P., see Patel, I. H., 555Welch, R. M., see Butz, R. F., 602Westfall, D. P., see Abel, P. W.,

430

White, J. M. and Holtzman, S. G.:Three-choice drug discrimi-nation in the rat: Morphine,cyclazocine and saline, 254

Willette, R. N., see Sapru, H. N.,228

Wilson, S. E., see Levin, J. A., 162

Wilson, W. A., see Zbicz, K. L,222

Wise, W. E., see La Morte, W. W.,

638Withdrawal, of ethanol, sponta-

neous hind leg movements(rats), 666

Woods, J. H., see Valentino, R J.,

652

Woodward, J. K., see Cheng, H.C., 121

Woolverton, W. L. and Balster, R.

L.: Effects of combinations ofphencyclidine and pentobar-bital on fixed-interval per-formance in rhesus monkeys,

611

Wurtman, R. J., see Hefti, F., 189Wurzburger, R. J., Miller, R. L.,

Marcum, E. A., Colburn, W.

A. and Spector, S.: A newradioimmunoassay for halo-

peridol: Direct measurementof serum and striatal concen-trations, 757

Xylamine, actions on central nor-adrenergic neurons (rats),

834

Yaden, E. L., see Ruffolo, R. R.,Jr., 235

Yamamoto, S., Akera, T., Kim,D.-H. and Brody, T. M.: Tis-sue concentration of Na�,K�-adenosine tniphosphataseand the positive inotropic ac-tion of ouabain in guinea-pigheart, 701

Yeoh, P. N., see Kao, C. Y., 416Yohimbine, differentiation of

postsynaptic alpha adrener-gic receptors in tissues by(rats), 235

Yoshida, K., see Masuda, Y., 805

Yousefnejad, D., see Shannon, H.E., 379

Yue, T. L. and Varma, D. R.: In-fluence of protein deficiencyon lysosome stabilizing andpaw edema suppressant ac-tivity ofsteroidal and nonste-roidal anti-inflammatoryagents in rats, 776

Zacharov, S. I., see Gilmour, R.G., Jr., 390

Zbicz, K. L. and Wilson, W. A.:Barbiturate enhancement of

spike frequency adaptation inAplysia giant neurons, 222

Zincinhibition of in vitro histamine

release from basophils (man),292

serum concentrations and sei-zures, influence of D-penicil-lamine (baboons), 138

Zipes, D. P., see Gilmour, R. G.,

Jr., 390Zook, T. E. and Strandhoy, J. W.:

Mechanisms of the natri-

uretic and diuretic effects ofprostaglandins F2,,, 674

Zysset, T. and Bircher, J.: Pref-erential reduction of first-pass elimination by ethanol.Model experiments with do-methiazole in the rabbit, 198

the rnostrS

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December (I) Volume3l5 Numberl 1980

F. Drago, G. Gorgone, F. Spina, G. Panissidi,A. Dal Bello, F. Moro, U. Scapagnini : OpiateReceptors in the Rabbit Iris 1

R. F. Bruns: Adenosine Receptor Activation by

Adenine Nucleotides Requires Conversion of theNucleotides to Adenosine 5

V. Koga, H. Downes, S. M.Taylor: Direct andIndirect Actions of Dopamine on Tracheal SmoothMuscle 15

w, Kobinger, 1. Pichler: Relation BetweenCentral Sympathoinhibitory and Peripheral Pre-and Postsynaptic a-Adrenoceptors as Evaluated byDifferent Clonidine-Like Substances in Rats 21

s.J. Publicover, C.J. Duncan: Stimulation ofthe Frequency of MEPPs at the FrogNeuromuscular Junction by Extracellular EGTA29

H. C. Moises, B. J. Hoffer, D. J. Woodward:GABA Facilitation by Noradrenaline Shows

Supersensitivity in Cerebellum after6-Hydroxydopamine 37

T. Ehara, M. Inazawa: Calcium-Dependent SlowAction Potentials in Potassium- DepolarizedGuinea-Pig Ventricular Myocardium Enhanced byBarium Ions 47

M. Kohlhardt, C. Seifert: Inhibition of Vmax of

the Action Potential by Propafenone and ItsVoltage-, Time- and pH-Dependence inMammalian Ventricular Myocardium 55

M. A. Evans : Effects of Anticonvulsants andMethotrexate on Calcium Disposition 63

T. Kishimoto, N. Urakawa : The Inhibitory Effectof Lithium on High-K Induced Contraction inGuinea-Pig Taenia Coli 69

C.J.Duncan, H. C. Greenaway, J. L. Smith:2,4- Dinitrophenol, Lysosomal Breakdown andRapid Myofilament Degradation in VertebrateSkeletal Muscle 77

Short Communications

J. M#{246}hring, J. Schoun, J. Kintz, R. McNeill:Decreased Vasopressin Content in Brain Stem ofRats with Spontaneous Hypertension 83

N. Rohm, J. Wagner, H. J. SchUmann : TheLack of a Pronounced Preference of Prenalterol forthe Beta-i -Adrenoceptor Subtype 85

Indexed in Current Contents

Springer InternationalNaunyn-Schmiedeberg’s Arch. Pharmacol

�- ISSN 0028-1 298 NSAPCC 31 5(1 ) 1 - 88 (1980)