reward-summation function of the priming effect · reward-summation function pulse frequency (hz)...
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Reward-Summation Function of the Priming Effect
Esthelle Ewusi-Boisvert
Concordia University
October 28th, 2015
Objective
•Examine the effect of priming on motivation
in rats
2
Motivation
3(Kelley & Berridge, 2002)
5
Priming effect
6
Sample RewardEnhancement in
motivation
Priming effect
7
Sample RewardEnhancement in
motivation
Priming effect
8
Sample RewardEnhancement in
motivation
Background
9(Gallistel et al., 1966)
Background
10
Background
11
12
Background
13
14(Sinnamon & Stopford, 1987)
Operant box paradigm
15
Reward-summation function
Pulse Frequency (Hz)
Re
wa
rd-s
ee
kin
g p
erf
orm
an
ce 100
0
0 35016
Reward-summation function
Unprimed
Primed
17(Gallistel et al., 1974)
Pulse Frequency (Hz)
Pe
rfo
rma
nc
e
(ru
nn
ing
sp
ee
d)
100
0
0 350
Reward-summation function
Pulse Frequency (Hz)
Unprimed
Primed
Pe
rfo
rma
nc
e
(ra
te o
f b
ar
pre
sse
s)100
0
0 35018
(Gallistel et al., 1974)
Left shift
Pe
rfo
rma
nc
e (
rate
of
ba
r p
ress
es)
100
0
Pulse Frequency (Hz)0 350
19
Unprimed
Primed
Single pulse frequency
Pe
rfo
rma
nc
e (
rate
of
ba
r p
ress
es) RAT A RAT B
Pulse Frequency (Hz)
0 176 350 0 176 350
Pe
rfo
rma
nc
e (
rate
of
ba
r p
ress
es)
Pulse Frequency (Hz)
100
0
100
0
20
300 200
Our aim
•Using an operant paradigm, we will examine
the effect of electrical priming stimulation on
the reward summation function
21
Method
• Five Long-Evans rats (N=5)
•2x9 within-subjects design
•Counterbalanced conditions
22
Proposed design
23
Pulse Frequencies
Priming
Conditions
PF
1
PF
2
PF
3
PF
4
PF
5
PF
6
PF
7
PF
8
PF
9
Primed
Unprimed
Proposed design
Pe
rfo
rma
nc
e (
rate
of
ba
r p
ress
es)
Pulse Frequency (Hz) 24
Proposed design
Priming/No priming
Setup Lever
Reward
25
Proposed design
Priming/No priming
26
Proposed design
Setup Lever
27
Proposed design
Reward
28
1
2
…
Unprimed Primed … 120min.
29
Primed Unprimed … 120min.
Expected results
Unprimed
Priming
30
Pe
rfo
rma
nc
e (
rate
of
ba
r p
ress
es)
100
0
Pulse Frequency (Hz)0 350
Pulse Frequency (Hz)
Pe
rfo
rma
nc
e
(ru
nn
ing
sp
ee
d) 100
0
0 350
Data analysis
•Repeated measures ANOVA
•Post-hoc tests
31
Data analysis
Pe
rfo
rma
nc
e (
rate
of
ba
r p
ress
es)
Pulse Frequency (Hz) 32
Data Analysis
•Repeated measures ANOVA
•Post-hoc tests
33
Limitations
•Electrode placement
•ESB and specificity
34
Discussion
•Motivation
•Pulse frequency levels
• Implications for substance abuse research
35
Acknowledgements
•Dr. Wayne Brake
•Dr. Peter Shizgal
•Czarina Evangelista
•Kent Conover
• Steve Cabilio
• Sarah Nolan-Poupart
•CSBN
36
Priming and motivation
37(Deutsch et al., 1964)
Neurobiology
38
39
Relapse
40