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Reward-Summation Function of the Priming Effect
Esthelle Ewusi-Boisvert
Concordia University
April 15th, 2016
Objective
•Examine the effect of priming on motivation
in rats
2
Motivation
•Goal-oriented behaviour
•Enhancement in vigor
(Salamone, Correa, Farra, & Mingote, 2007)
Priming effect
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Sample RewardEnhancement in
motivation
Priming effect
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Sample RewardEnhancement in
motivation
Priming effect
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Sample RewardEnhancement in
motivation
(Gallistel et al., 1966)
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(Gallistel, Stellar & Bubis, 1974)
(Gallistel, Stellar & Bubis, 1974)
Operant box paradigm
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Tim
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Pulse Frequency (Hz)0
1
0.5
Research Aim
•Using an operant paradigm, we examined
the effect of electrical priming stimulation on
the reward-summation function
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Method
• Three male Long-Evans rats (N=3)
•2x9 within-subjects design
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High priming/Low
priming
Setup Lever
Reward Lever
Tim
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Pulse Frequency (Hz)
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0
1
0.5
Low
priming
150
trials
High
priming
150
trials
High
priming
150
trials
Low
priming
150
trials
DAY 1
DAY 2
Data Integrity and Analysis
•All data collected was analyzed
•Bootstrapping
•Smoothing spline
Me
an
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Log Pulse Frequency
Subject 1
Log Pulse Frequency
Subject 2
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Subject 3
Log Pulse Frequency
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spo
nse
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d Subject 1
Log Pulse Frequency
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d Subject 2
Log Pulse Frequency
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d Subject 3
Log Pulse Frequency
Limitations
•Variations in vigor
• Small sample size
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Discussion
•Narrow gradations
•Dopamine depletion
•Relapse
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Future Directions
• Increase spacing
• Fixed Ratio Schedule
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Acknowledgements
•Dr. Wayne Brake
•Dr. Peter Shizgal
•Czarina Evangelista
•Kent Conover
• Steve Cabilio
• Sarah Nolan-Poupart
•Dr. Rex Kline
• Jason Payne
• Franz Villaruel
•CSBN28
Relapse
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Me
an
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Log Pulse Frequency
Subject 3