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in-ADME Research Copyright © 2011 Selected Publications A. Avdeef in-ADME Research www.in-ADME.com

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Page 1: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Selected PublicationsA. Avdeef

in-ADME Research

www.in-ADME.com

Page 2: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Page 3: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Page 4: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Page 5: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Page 6: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

J. Pharm. Sci. 2007, 96, 2893-2909

pIONRocheWyethNovartisPfizer

PAMPA “white paper”

Page 7: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Blood-Brain Barrier

pIONAmgen AstraZeneca

Eur. J. Pharm. Sci. 2009, 38, 421-137Pharm. Res. 2011, 28, 337-363Pharm. Res. 2011, 28, 517-530

Page 8: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Caco-2 pH ProfileDrug Disc. Today, 2003, 8, 997Eur. J. Pharm. Sci., 2004, 21,429Eur. J. Pharm. Sci., 2005, 24, 333

pIONKing’s College LondonValencia UnivUppsala Univ

Caco-2 & PAMPA

Page 9: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

pIONAstraZeneca

Pharm. Res. 2010, 27, 480-486J. Med. Chem. 2010, 53, 3566-3584Eur. J. Pharm. Sci. 2011, 43, 109-124

Paracellular

Page 10: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Pharm. Res. 2006,23,2525Pharm.Res.2007,24, 530Eur. J. Pharm. Sci. 2008, 33, 29

Absorption Classification Maps

pIONHoffman-La Roche

Page 11: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

Pharm. Res. 2008, 25, 2613Pharm. Res. 2009, 26, 2093Chem. Biodiv. 2009,11, 1796

Miniaturized Dissolution

(lowering API requirement by 10,000)

pIONpIONpION

Micro-Volume Dissolution

Page 12: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

PAMPA-skin

pIONSemmelweis Univ

Page 13: Research Publications in-ADME Research A. Avdeef

in-ADME Research Copyright © 2011 

pKa at 37oC

pION


Drug Discovery and Development Technology Center Drug Discovery Early-ADME &preformulation Pharmaceutical Nanotechnology Independent Research Centre in

Global ADME-Toxicology Testing Market 2015-2019

1 confidential ADME SOLUTIONS. 2 confidential CORE TECHNOLOGIES/PRODUCTS ADME Line of automated workstations for drug screening in discovery and development

Poster: QuantiGene Plex Analysis of ADME Gene Expression ...€¦ · QuantiGene Plex Analysis of ADME Gene Expression in Primary Human Hepatic 3D Spheroid Culture QuantiGene Plex

Livepoint adme brochure

in-ADME Research pCEL-X slides

ABSORPTION AND - Pharma research Library...ABSORPTION AND DRUG DEVELOPMENT Solubility, Permeability, and Charge State ALEX AVDEEF pION, Inc. A JOHN WILEY & SONS, INC., PUBLICATION

Indication and interpretation of investigation in toxicologytreatment monitoring... · ADME. ADME: Absorption, Distribution, Metabolism, and Excretion • The body has defenses: –

Prodrugs an approach to solve problems related to adme

Book of Abstracts · The Scientific and Organizing Committee: Alex Avdeef, In-ADME Research, USA Elena Boldyreva, Russian Academy of Sciences, Russia Biserka Cetina-Čižmek, PLIVA,

in-ADME Research Unbound-drug Brain Exposure

ADME Tox Market

ADME/Tox support - Thermo Fisher Scientific · ADME/Tox products for drug metabolism and safety ... CYP450 enzymes Gibco Human Microsomes, Single Donor Also available: • BACULOSOMES

MARINE ENGINEERING (ADME)

MARINE ENGINEERING (ADME) · MARINE ENGINEERING (ADME) Page 2 of 31 INTRODUCTION TO THE PROGRAMME & DETAILS ... COMPLEX NUMBER Complex Numbers and its properties, Argand Diagram,

Supplementary materials Molecular Docking, QSAR and ADME/T ... fileSupplementary materials Molecular Docking, QSAR and ADME/T Studies of withanolide analogs against breast cancer Dharmendra

Book of Abstracts · Alex Avdeef, In-ADME Research, USA Christel Bergström, Uppsala University, Sweden Biserka Cetina-Čižmek, PLIVA, Croatia Zoran Mandić, University of Zagreb,

ADME kimed

Personalized Medicine A new challenge for applied human ... - AGAH€¦ · • Expression of ADME enzymes and transporters (reduced/increased) • Inhibition of ADME enzymes and transporters

ADME Model Presentation, September 2011

ADME Health and Wealth Team

Pre-ADME Predictive Screening

Order of Kinetics, ADME

ADME And PHARMACOKINETICS. ADME lecture 1 Contents... What are ADME and Pharmacokinetics? Absorption Distribution

In Vitro ADME & Drug-Drug Interaction Considerations for ...€¦ · In Vitro ADME & Drug-Drug Interaction Considerations for Toxicologists Author: Pallavi Limaye, Ph.D., DABT, SEKISUI

Pharmacokinetics/ADME In Drug Discovery - UAB PK ADME.pdf · PK/ADME in Drug Discovery OiOverview • Pharmacokinetics, absorption, distribution, ... – Reduces the risk of non‐specific,

Development of An Educational Tool to Simulate ADME ... · Development of An Educational Tool to Simulate ADME Processes In Vitro By: Ashadi Ashadi ... Orgchem, 2013

ADME METABOLISM. ADME METABOLISM Strictly – the biological breakdown (catabolism) or synthesis (anabolism) of compounds

MARINE ENGINEERING (ADME) - · PDF filePage 2 of 31 INTRODUCTION TO THE PROGRAMME & DETAILS Name of the Programme : Associate Degree in Marine Engineering (ADME)

ADME/Tox sourcebook - Thermo Fisher

An overview of ADME Studies

Evaluation of the ADME, toxicological analysis and

In vivo kinetics of radiopharmaceuticals - ADME

ADME And Toxicity Optimization Services

Current Approaches for ADME Characterization of …...Current Approaches for ADME Characterization of Antibody-Drug Conjugates IQ- ADC ADME Working Group Feb 19, 2016 Team members: