in-adme research pcel-x slides

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in-ADME Research Copyright © 2011 in-ADME Research pCEL-X Rev 3.1 Overview 1. Atenolol Caco-2 Refinement 2. Amitriptyline Caco-2 Simulation 3. Amitriptyline in situ brain perfusion Refinement 4. BD Pre-coated PAMPA Plates Leak page 1 Presentation Copyrighted (C) 2011. in-ADME Research. All rights reserved. www.in-ADME.com

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Sample screen shots from pCEL-X program for permeability anlaysis of Caco-2, PAMPA, and BBB

TRANSCRIPT

Page 1: in-ADME Research pCEL-X slides

in-ADME Research Copyright © 2011 

in-ADME ResearchpCEL-X Rev 3.1

Overview1. Atenolol Caco-2 Refinement

2. Amitriptyline Caco-2 Simulation

3. Amitriptyline in situ brain perfusion Refinement

4. BD Pre-coated PAMPA Plates Leak

page 1

Presentation Copyrighted (C) 2011. in-ADME Research. All rights reserved.

www.in-ADME.com

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in-ADME Research Copyright © 2011 

Caco-2 Refinement Example

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Simulation Example

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Refinement of in situ Data

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BD Pre-Coated PAMPA Plates

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Thin Membranes Leak Water & Can’t be Stirred

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Thin Membranes Leak Water & Can’t be Stirred

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Thin Membranes Leak Water & Can’t be Stirred

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Thin Membranes Leak Water & Can’t be Stirred

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