remote memory
DESCRIPTION
Remote memory. Hippocampus Neocortex Retrograde amnesia Nongraded amnesia (Spatial memory tasks) Multiple trace theory. methods. Physical studies Pharmacological studies Genetic lesion studies Cellular and temporal precise Optogenetics ( Opsin Genes). - PowerPoint PPT PresentationTRANSCRIPT
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Remote memory
Hippocampus Neocortex
Retrograde amnesiaNongraded amnesia (Spatial memory tasks)
Multiple trace theory
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methods
Physical studiesPharmacological studies
Genetic lesion studies
Cellular and temporal precise
Optogenetics (Opsin Genes)
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Specific Optogenetic Inhibition (OGI)of Excitatory Neurons in Dorsal CA1 Reduces
Neuronal Activity
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A temporally precise, stable and reversible manner
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CA1 OGI Blocks Contextual Fear Acquisition and Retrirval
A real-time involvement of CA1 excitatory cells, during acquisition and recall
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No difference in exploration
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Acquisition and expression of fear denpend on the amygdala
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CA1 OGI Reversibly Interferes with Remote Fear Memory Recall
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Ongoing involvement, default activator of the memory trace
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Disturb only recent but not remoteOPI limits expression of compensatory mechanisms
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Precise but Not Prolonged CA1 OGI Blocks Remote Contextual Fear Recall
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Interrupted in the midst of a behavioral sessionHippocampus participate in remote memory trace maintenance
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Brain-wide Mapping of Circuit Activity Controlled by the Hippocampus during
Remote Recall
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CA1 recruiting brain-wide fear memory activityIncreased activity compensating for hippocampal inactivation
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OGI of Anterior Cingulate Cortex (ACC) Inhibits Remote but Not Recent Contextual Memory
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Olfactory bulbs (OB), no effect
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Point not clear
This result at once demonstrates that a sudden drop in a major source of synaptic input to cortex need not nonspecifically influence recall (without ruling out a contribution from such an effect) and also points to the specificity of ACC in remote memory (consistent with prior work).