remote memory

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Remote memory. Hippocampus Neocortex Retrograde amnesia Nongraded amnesia (Spatial memory tasks) Multiple trace theory. methods. Physical studies Pharmacological studies Genetic lesion studies Cellular and temporal precise Optogenetics ( Opsin Genes). - PowerPoint PPT Presentation

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Page 1: Remote memory
Page 2: Remote memory

Remote memory

Hippocampus Neocortex

Retrograde amnesiaNongraded amnesia (Spatial memory tasks)

Multiple trace theory

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methods

Physical studiesPharmacological studies

Genetic lesion studies

Cellular and temporal precise

Optogenetics (Opsin Genes)

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Specific Optogenetic Inhibition (OGI)of Excitatory Neurons in Dorsal CA1 Reduces

Neuronal Activity

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A temporally precise, stable and reversible manner

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CA1 OGI Blocks Contextual Fear Acquisition and Retrirval

A real-time involvement of CA1 excitatory cells, during acquisition and recall

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No difference in exploration

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Acquisition and expression of fear denpend on the amygdala

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CA1 OGI Reversibly Interferes with Remote Fear Memory Recall

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Ongoing involvement, default activator of the memory trace

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Disturb only recent but not remoteOPI limits expression of compensatory mechanisms

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Precise but Not Prolonged CA1 OGI Blocks Remote Contextual Fear Recall

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Interrupted in the midst of a behavioral sessionHippocampus participate in remote memory trace maintenance

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Brain-wide Mapping of Circuit Activity Controlled by the Hippocampus during

Remote Recall

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CA1 recruiting brain-wide fear memory activityIncreased activity compensating for hippocampal inactivation

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OGI of Anterior Cingulate Cortex (ACC) Inhibits Remote but Not Recent Contextual Memory

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Olfactory bulbs (OB), no effect

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Point not clear

This result at once demonstrates that a sudden drop in a major source of synaptic input to cortex need not nonspecifically influence recall (without ruling out a contribution from such an effect) and also points to the specificity of ACC in remote memory (consistent with prior work).