Recent Results in Cancer Research 160

Managing Editors

P. M. Schlag, Berlin . H.-J. Senn, St. Gallen

Associate Editors

P. Kleihues, Lyon . F. Stiefel, Lausanne B. Groner, Frankfurt· A. Wallgren, Goteborg

Founding Editor

P. Rentchnik, Geneva

Springer Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Tokyo

R. Dummer F. O. Nestle G. Burg (Eds.)

Cancers of the Skin Proceedings of the 8th World Congress

With 41 Figures and 27 Tables

Springer

Prof Dr. Reinhard Dummer PD Dr. Frank o. Nestle Prof Dr. Gunter Burg

University of Zurich Department of Dermatology Gloriastr. 31 8091 Zurich, Switzerland

Indexed in Current Contents and Index Medicus

ISBN-13:978-3-642-63969-2 Springer-Verlag Berlin Heidelberg New York ISSN 0080-0015

Library of Congress Cataloging-in-Publication Data Die Deutsche Bibliothek - CIP-Einheitsaufnahme Cancers of the skin: proceedings of the 8th world congress; with 25 tables 1 [The Eight World Congress on Cancers of the Skin, July 18-21, 2001, Zurich, Switzerland]. R. Dum­mer ... (ed.). - Berlin; Heidelberg; New York; Barcelona; Hong Kong; London; Milan; Paris; Tokyo: Springer, 2002

(Recent results in cancer research; 160) ISBN-13:978-3-642-63969-2 e-ISBN-13:978-3-642-59410-6 DOl: 10.1007/978-3-642-59410-6

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illus­trations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Viola­tions are liable for prosecution under the German Copyright Law.

Springer-Verlag Berlin Heidelberg New York a member of BertelsmannSpringer Science+ Business Media GmbH

http://www.springer.de

© Springer-Verlag Berlin . Heidelberg 2002 Softcover reprint of the hardcover 1st edition 2002

The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature.

Production: PRO EDIT GmbH, 69126 Heidelberg, Germany Typesetting: K+V Fotosatz GmbH, 64743 Beerfelden, Germany Cover design: design&production GmbH, 69121 Heidelberg, Germany

Printed on acid-free paper SPIN 10745806 21/3130ML 5 4 3 2 1 0

Contents

1 Prevention

Public Education in Skin Cancer World-Wide G. Burg

UV Protection and Skin Cancer R. Dummer, T. Maier

2 UV Protection by Clothes

3

7

Role of Clothes in Sun Protection . . . . . . . . . . . . . . . . . . . . . . .. 15 T. Gambichler, P. Altmeyer, K. Hoffmann

Sun Protective Clothing: 5 Years of Experience in Australia . . . . . . .. 26 C. R. Roy, P. H. Gies, A. McLennan

European Standards for Protective Apparel Against UV Radiation 35 J. Laperre, F. Foubert

American Standards for UV-Protective Textiles . . . . . . . . . . . . . . .. 42 K.L. Hatch

Activities of (IE DIV-6 (Photobiology and Photochemistry) in UV Protection and Clothing . . . . . . . . . . . . . . . . . . . . . . . . .. 48

J. P. Cesarini

Comparison of Methods: Determination of UV Protection of Clothing ......•...•...... 55

T. Gambichler, P. Altmeyer, K. Hoffmann

VI Contents

Improving UV Protection by Clothing - Recent Developments . . . . .. 62 U. Osterwalder, H. Rohwer

Dress up for Sun Protection/Creation of Public Awareness P. Cesarini

3 Melanoma

Pathogenesis

70

The Precursors of Malignant Melanoma ..•................. 75 A. N. Crowson, C. M. Magro, I. Sanchez-Carpintero, M. C. Mihm Jr.

Interferon-a Sensitivity in Melanoma Cells: Detection of Potential Response Marker Genes .......... 85

U. Certa, M. Seiler, E. Padovan, G. C. Spagnoli

Molecular Cytogenetics as a Diagnostic Tool for Typing Melanocytic Tumors ......................... 92

B.c. Bastian

Loss of Heterozygosity and Microsatellite Instability in Acquired Melanocytic Nevi: Towards a Molecular Definition of the Dysplastic Nevus .... . . . . . . . . . . . . . . . . . . . . . . . . .. 100

A. Rilbben, I. Bogdan, E. I. GrujJendorf-Conen, G. Burg, R. Boni

Epidemiology

The Changing Incidence and Mortality of Melanoma in Australia . . .. 113 R. Marks

Diagnostic

Why Is Epiluminescence Microscopy Important? . . . . . . . . . . . . . .. 125 K. Wolff

Sentinel Node Biopsy: Not Only a Staging Tool? .............. 133 R. Essner, A. J. Cochran

Therapy

The Impact of Surgery on the Course of Melanoma ............ 151 F. J. Lejeune

Contents VII

Perspectives of Pegylated Interferon Use in Dermatological Oncology 158 H. Pehamberger

Dendritic Cell Vaccination for the Treatment of Skin Cancer ....•.• 165 F. o. Nestle

Gene-based Immunotherapy of Skin Cancers . . . . . . . . . . . . . . . .. 170 Y. Sun, D. Schadendorf

Cytokine-Fusion-Protein-Treatment ....................... 185 D. Schrama, P. thor Straten, E.-B. Bracker, R. A. Reisfeld, J. c. Becker

Cytotoxic T-cell Induction in Metastatic Melanoma Patients Undergoing Recombinant Vaccinia Virus-based Immuno-gene Therapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 195

G. C. Spagnoli, P. Zajac, W. R. Marti, D. Oertli, E. Padovan, C. Noppen, T. Kocher, M. Adamina, M. Heberer

Follow-up

A Rational Approach to the Follow-up of Melanoma Patients ...... 205 C. Garbe

4 Epithelial Skin Tumors

Therapy

Micrographic Surgery of Basal Cell Carcinomas of the Head ....... 219 B. Woerle, M. Heckmann, B. Konz

Repair of Cutaneous Defects After Skin Cancer Surgery M. Hess Schmid, C. Meuli-Simmen, J. Hafner

225

Radiotherapy of Skin Tumors. . . . . . . . . . . . . . . . . . . . . . . . . .. 234 R. Panizzon

Photodynamic Therapy and Fluorescence Diagnosis of Skin Cancers .. 240 R. M. Szeimies, M. Landthaler

Intralesional Interferon in Basal Cell Carcinoma: How Does It Work? .• 246 S. Buchner, M. Wernli, F. Bachmann, T. Harr, P. Erb

VIII Contents

Epithelial Malignancies in Organ Transplant Patients: Clinical Presentation and New Methods of Treatment ......•.... 251

E. Stockfleth, C. Ulrich, T. Meyer, E. Chris top hers

New Treatment Modalities for Basal Cell Carcinoma E. Stockfleth, W. Sterry

5 Lymphoma

Pathogenesis

From Inflammation to Neoplasia: New Concepts in the Pathogenesis

259

of Cutaneous Lymphomas ............................ 271 G. Burg, W. Kempf, A. Haeffner, U. Dobbeling, F. O. Nestle, R. Boni, M. Kadin, R. Dummer

Clinical Presentations

Cutaneous Lymphomas and Pseudo lymphomas: Newly Described Entities ............................. 283

D. Kazakov, G. Burg, R. Dummer, W. Kempf

Clinical Aspects and Pathology of Primary Cutaneous B-Cell Lymphomas ..................................... 294

H. Kerl, R. Fink-Puches, L. Cerroni

Diagnosis

Modern Diagnosis of Cutaneous Lymphoma •..........•..... 303 B. Giannotti, N. Pimpinelli

Therapy

Treatment of Cutaneous T Cell Lymphoma: 2001 .............. 309 E.C. Vonderheid

New Biologic Agents for the Treatment of Cutaneous T-Cell Lymphoma ......................... 321

C. C. Vittorio, J. M. Junkins-Hopkins, M. Shapiro, M. Wysocka, M. H. Zaki, L. E. French, A. H. Rook

Contents IX

6 Mesenchymal Tumors

Etiology and Pathogenesis of Kaposi's Sarcoma ............... 331 B. Nickoloff, K. E. Foreman

Connective Tissue Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 343 B. Zeiger

7 Psychosocial Aspects

How to Identify Patients in Need of Psychological Intervention ..... 351 G. Strittmatter, M. Tilkorn, R. Mawick

Psychotherapeutic Interventions in Melanoma Patients .......... 362 W. Sollner, R. Gross, S. Maislinger

Subject Index ................................... 371

Principal Authors

Boris C. Bastian, MD Comprehensive Cancer Center and Department of Dermatology and Pathology University of California 2340 Sutter Street San Francisco, CA 94115, USA

Jurgen C. Becker, MD Department of Dermatology Julius Maximilians University J osef-Schneider-Str. 2 97080 Wurzburg, Germany

Stanislaw Buchner, MD Department of Dermatology University of Basel Kantonsspital Peters graben 4 4031 Basel, Switzerland

Gunter Burg, MD Department of Dermatology University Hospital of Zurich Gloriastr. 31 8091 Zurich, Switzerland

Ulrich Certa, MD F. Hoffmann-La Roche Ltd. Pharmaceuticals Division Bldg. 93/610 4070 Basel, Switzerland

Jean-Pierre Cesarini, MD CIE Division 6 Laboratoire de Recherche sur les Tumeurs de la Peau Humaine Fondation Adolphe de Rothschild 25, rue Manin 75019 Paris, France

Pierre Cesarini Association Securite Solaire (WHO Collaborating Center) 25, rue Manin 75019 Paris, France

Reinhard Dummer, MD Department of Dermatology University Hospital of Zurich Gloriastr. 31 8091 Zurich, Switzerland

XII Principal Authors

Richard Essner, MD John Wayne Cancer Institute 2200 Santa Monica Blvd. Santa Monica, CA 90404, USA

Thilo Gambichler, MD Department of Dermatology Ruhr University Bochum Gudrunstr. 56 44791 Bochum, Germany

Claus Garbe, MD Department of Dermatology Eberhard Karls University Liebermeisterstr. 25 72076 Tiibingen, Germany

Monika Hess Schmid, MD Department of Dermatology University Hospital of Zurich Gloriastr. 31 8091 Zurich, Switzerland

Kathryn L. Hatch, PhD The University of Arizona Department of Agriculture and Biosystems Engineering College of Agricultural and Life Sciences Shantz 403 PO Box 21 0023 Tucson, AZ 85721-0038, USA

Werner Kempf, MD Department of Dermatology University Hospital of Zurich Gloriastr. 31 8091 Zurich, Switzerland

Helmut Kerl, MD Department of Dermatology University of Graz Auenbruggerplatz 8 8036 Graz, Austria

Rolf-Markus Szeimies, MD Department of Dermatology University of Regensburg Franz-Josef-Strauss-Allee 11 93053 Regensburg, Germany

Jan Laperre, PhD Centexbel, Technical and Scientific Centre of the Belgian Textile Industry Technologiepark 7 9052 Zwijnaarde, Belgium

Ferdy J. Lejeune, MD Centre Pluridisciplinaire d'Oncologie Centre Hospitalier Universitaire Vaudois Rue du Bugnon 46 1011 Lausanne, Switzerland

Robin Marks, MBBS, MPH, FRACP, FACD University of Melbourne Department of Medicine (Dermatology) St. Vincent's Hospital Melbourne Skin & Cancer Foundation of Victoria Fitzroy, Victoria 3065, Australia

Martin C. Mihm Jr., MD Department of Pathology Massachusetts General Hospital Harvard Medical School Warren Building, Room 827 55 Fruit Street Boston, MA 02214, USA

Frank o. Nestle, MD Department of Dermatology University Hospital of Zurich Gloriastr. 31 8091 Zurich, Switzerland

Brian J. Nickoloff, MD, PhD Department of Pathology and Skin Cancer Research Laboratories Cardinal Bernardin Cancer Center, Room 301 Loyola University Medical Center 2160 South First Avenue Maywood, IL 60153, USA

Uli Osterwalder Ciba Speciality Chemicals Klybeckstr. 147 4002 Basel, Switzerland

Renato G. Panizzon, MD Department of Dermatology University Hospital 29 avo Beaumont 1011 Lausanne, Switzerland

Hubert Pehamberger, MD Department of Dermatology University of Vienna Vienna General Hospital Wahringer Giirtel 18-20 1090 Vienna, Austria

Nicola Pimpinelli, MD, PhD Department of Dermatological Sciences University of Florence Medical School Via degli Alfani, 37 50121 Florence, Italy

Alain H. Rook, MD Professor of Dermatology University of Pennsylvania School of Medicine 3600 Spruce Street Philadelphia, PA 19104, USA

Principal Authors XIII

Colin R. Roy, PhD ARPANSA Lower Plenty Road Yallambie VIC 3085 Australia

Albert Riibben, MD Hautklinik Universitatsklinikum der RWTH Aachen Pauwelsstr. 30 52074 Aachen, Germany

Dirk Schadendorf, MD Klinische Kooperationseinheit fUr Dermatoonkologie (DKFZ) an der Universitats-Hautklinik Mannheim Universitat Heidelberg Theodor-Kutzer-Ufer 1 68135 Mannheim, Germany

Wolfgang Sollner, MD Department of Medical Psychology and Psychotherapy University Hospital Sonnenburgstr. 9 6020 Innsbruck, Austria

Giulio C. Spagnoli, MD Department of Surgery Division of Research University Hospital Basel Hebelstr. 20 4031 Basel, Switzerland

Eggert Stockfleth, MD Department of Dermatology Christian Albrechts University Schittenhelmstr. 7 24105 Kiel, Germany

XIV Principal Authors

Gerhard Strittmatter, Dr. rer. medic. Department of Psychosocial Oncology Fachklinik Hornheide Dorbaumstr. 300 48157 Munster, Germany

Eric C. Vonderheid, MD MCP Hahnemann University Mailstop 478, Broad and Vine Streets Philadelphia, PA 19102, USA

Birgit Woerle, MD Department of Dermatology Rheinische Friedrich­Wilhelms-UniversiUit Sigmund-Freud-Str. 25 53105 Bonn, Germany

Klaus Wolff, MD, FRCP Department of Dermatology University of Vienna Vienna General Hospital Wahringer Gurtel 18-20 1090 Vienna, Austria

Bernhard ZeIger, MD Department of Dermatology University of Innsbruck Anichstr. 35 6020 Innsbruck, Austria