re: abdulwahed et al.: sensitivity and specificity of ultrasonography in predicting etiology of...

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Handan Cakmakci, M.D. Department of Radiology Dokuz Eylul University Faculty of Medicine Izmir, Turkey References 1. Alaygut D, Soylu A, Kasap B, et al. The relationships between renal compensatory hypertrophy etiologic factors and anthropometric development in the pediatric age group [e-pub ahead of print]. Urology. doi: 10.1016/j.urology.2013.03.024, accessed May 12, 2013. 2. Garg M, Singh V, Sankhwar S, et al. Re: Alaygut D et al.: The relationships between renal compensatory hypertrophy etiologic factors and anthropometric development in the pediatric age group. Urology. 2013;82.:1189-1190. Re: Abdulwahed et al.: Sensitivity and Specicity of Ultrasonography in Predicting Etiology of Azoospermia (Urology 2013;81: 967-971) TO THE EDITOR: We congratulate the authors for describing the ultraso- nographic features of obstructive and functional azoo- spermia. The authors contend that ultrasonography can possibly replace testicular biopsy in some men with azoospermia. However, the authors have used criteria such as evidence of prostatitis, epididymitis, small size prostate, and small size seminal vesicles for differentiating obstructive with functional azoospermia. Most of these criteria are poorly dened in the published data and difcult to evaluate. We would like to know how the sensitivity and spec- icity were calculated. The authors have described multiple ndings on ultrasonography. Which parameter or combinations of nding were taken to calculate these values? We should remember that ultrasonography is an operator-dependant investigation and prone to error. Therefore, it may be difcult to interpret this test result with condence. Apul Goel, M.B.B.S., M.S., M.Ch. (Urology) D.N.B. (Urology) Sagorika Paul, M.B.B.S., M.S. (General Surgery) Ved Prakash Verma, M.B.B.S., M.S. (General Surgery) Department of Urology King Georges Medical University Chowk, Lucknow, Uttar Pradesh, India Reply by the Authors TO THE EDITOR: We agree that sonographic ndings are suggestive rather than diagnostic to pathologic diagnoses such as prostatitis and epididymitis and might be prone to error. In this study, we aimed to demonstrate how close is the diagnostic yield of ultrasound to the more accurate but invasive testicular biopsy in differentiating obstructive from functional azoospermia. Concerning calculation of the sensitivity and speci- city of scrotal and transrectal ultrasound in the present study, the radiologist e who was blinded to the results of biopsy e was asked not only to collect ultrasound ndings but also suggest a diagnosis and the nature of azoospermia whether obstructive or functional in each case on the basis of the ndings of scrotal and transrectal ultrasound separately. Comparing the radiological suggested nature of azoo- spermia e in each ultrasound modality e with the sure results of histopathologic diagnosis of testicular biopsy allows detecting true and false, positive and negative diagnosis, and consequently the sensitivity and specicity of each technique separately. Ehab ElGanainy, M.D. Department of Urology Assiut University Assiut, Egypt Re: Safwat et al.: Percutaneous Suprapubic Stone Extraction for Posterior Urethral Stones in Children: Efcacy and Safety (Urology 2013;82:448-450) TO THE EDITOR: We read the article with interest and appreciate the authors for describing the use of minimally invasive treatment modality in children for posterior urethral stones. We have some comments regarding the study. The authors have mentioned that in 45 of the 54 patients, stone was removed intact with a 3-mm skin incision. The mentioned stone size was ranged from 0.8 to 1.9 cm. It is quite difcult to remove a stone of this size along with anges of hemostat through a 3 mm skin incision, and forceful retrieval will increase the size of incision. In addition, the authors should clarify that either they attempted for intact removal of stones in all patients or they choose any criteria such as stone size or hardness for fragmentation. Discussion about the mean stone size in patients in whom intact removal was possible will give a better idea about the cutoff size of stones for intact removal by this technique. Sometimes, in impacted stones, push back of stones in bladder is not possible and in situ fragmentation might require. In the study by Maheshwari and Shah, 1 in 18 of the 42 patients who presented with symptomatic urethral calculi, attempted push back was failed. 1 They conclude that intracorporeal intraurethral holmium lasertripsy is a feasible, safe, and effective modality for impacted male urethral stones. 1 However, the authorsapproach is a UROLOGY 82 (5), 2013 1191

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Handan Cakmakci, M.D.Department of Radiology

Dokuz Eylul University Faculty of MedicineIzmir, Turkey

References

1. Alaygut D, Soylu A, Kasap B, et al. The relationships between renalcompensatory hypertrophy etiologic factors and anthropometricdevelopment in the pediatric age group [e-pub ahead of print].Urology. doi: 10.1016/j.urology.2013.03.024, accessed May 12, 2013.

2. Garg M, Singh V, Sankhwar S, et al. Re: Alaygut D et al.: Therelationships between renal compensatory hypertrophy etiologicfactors and anthropometric development in the pediatric age group.Urology. 2013;82.:1189-1190.

Re: Abdulwahed et al.: Sensitivity andSpecificity of Ultrasonography in PredictingEtiology of Azoospermia (Urology 2013;81:967-971)

TO THE EDITOR:

We congratulate the authors for describing the ultraso-nographic features of obstructive and functional azoo-spermia. The authors contend that ultrasonography canpossibly replace testicular biopsy in some men withazoospermia. However, the authors have used criteriasuch as evidence of prostatitis, epididymitis, small sizeprostate, and small size seminal vesicles for differentiatingobstructive with functional azoospermia. Most of thesecriteria are poorly defined in the published data anddifficult to evaluate.

We would like to know how the sensitivity and spec-ificity were calculated. The authors have describedmultiple findings on ultrasonography. Which parameteror combinations of finding were taken to calculate thesevalues? We should remember that ultrasonography is anoperator-dependant investigation and prone to error.Therefore, it may be difficult to interpret this test resultwith confidence.

Apul Goel, M.B.B.S., M.S., M.Ch. (Urology)D.N.B. (Urology)

Sagorika Paul, M.B.B.S., M.S. (General Surgery)Ved Prakash Verma, M.B.B.S., M.S. (General Surgery)

Department of UrologyKing George’s Medical University

Chowk, Lucknow, Uttar Pradesh, India

Reply by the Authors

TO THE EDITOR:

We agree that sonographic findings are suggestive ratherthan diagnostic to pathologic diagnoses such as prostatitisand epididymitis and might be prone to error.

UROLOGY 82 (5), 2013

In this study, we aimed to demonstrate how close is thediagnostic yield of ultrasound to the more accurate butinvasive testicular biopsy in differentiating obstructivefrom functional azoospermia.

Concerning calculation of the sensitivity and speci-ficity of scrotal and transrectal ultrasound in the presentstudy, the radiologist e who was blinded to the results ofbiopsy e was asked not only to collect ultrasound findingsbut also suggest a diagnosis and the nature of azoospermiawhether obstructive or functional in each case on thebasis of the findings of scrotal and transrectal ultrasoundseparately.

Comparing the radiological suggested nature of azoo-spermia e in each ultrasound modality e with the sureresults of histopathologic diagnosis of testicular biopsyallows detecting true and false, positive and negativediagnosis, and consequently the sensitivity and specificityof each technique separately.

Ehab ElGanainy, M.D.Department of Urology

Assiut UniversityAssiut, Egypt

Re: Safwat et al.: Percutaneous SuprapubicStone Extraction for Posterior UrethralStones in Children: Efficacy and Safety(Urology 2013;82:448-450)

TO THE EDITOR:

We read the article with interest and appreciate theauthors for describing the use of minimally invasivetreatment modality in children for posterior urethralstones. We have some comments regarding the study.

The authors have mentioned that in 45 of the 54patients, stone was removed intact with a 3-mm skinincision. The mentioned stone size was ranged from 0.8to 1.9 cm. It is quite difficult to remove a stone of thissize along with flanges of hemostat through a 3 mm skinincision, and forceful retrieval will increase the sizeof incision. In addition, the authors should clarifythat either they attempted for intact removal of stones inall patients or they choose any criteria such as stonesize or hardness for fragmentation. Discussion about themean stone size in patients in whom intact removalwas possible will give a better idea about the cutoff sizeof stones for intact removal by this technique.

Sometimes, in impacted stones, push back of stones inbladder is not possible and in situ fragmentation mightrequire. In the study by Maheshwari and Shah,1 in 18 ofthe 42 patients who presented with symptomatic urethralcalculi, attempted push back was failed.1 They concludethat intracorporeal intraurethral holmium lasertripsy is afeasible, safe, and effective modality for impacted maleurethral stones.1 However, the authors’ approach is a

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