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Prostate Prostate Pathology Pathology Part 1 Part 1 Francisco G. La Rosa, MD Francisco G. La Rosa, MD Associate Professor, Department of Pathology Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado University of Colorado Denver, Aurora, Colorado

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Page 1: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Prostate Prostate PathologyPathology

Part 1Part 1

Francisco G. La Rosa, MDFrancisco G. La Rosa, MDAssociate Professor, Department of PathologyAssociate Professor, Department of Pathology

University of Colorado Denver, Aurora, ColoradoUniversity of Colorado Denver, Aurora, Colorado

Page 2: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

NORMAL ANATOMYNORMAL ANATOMY

Page 3: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Page 4: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

SAGITAL SECTION OF THE PROSTATE GLANDSAGITAL SECTION OF THE PROSTATE GLAND

SeminalVesicle

Central Zone

Bladder

Peri-urethralzone

Anterior ZoneFibro-muscular

PeripheralZone

TransitionZone

Urethra

Page 5: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

3D VIEW OF THE PROSTATE3D VIEW OF THE PROSTATE

Page 6: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

3D VIEW OF THE PROSTATE3D VIEW OF THE PROSTATE

Page 7: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

CROSS SECTION OF THE PROSTATECROSS SECTION OF THE PROSTATE

FIBROMUSCULAR STROMAanterior

PERI-URETHRALSTROMA

EJACULATORY DUCTS

Page 8: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

TRANZITIONALZONE

Seminal Vesicle

Urethra

Page 9: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

CENTRALZONE

Page 10: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Peripheral Zone

Page 11: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Fibro-muscular Stromaanterior

Page 12: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

HISTOLOGYHISTOLOGY

Page 13: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Bad HistologyBad Histology

Page 14: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Peripheral ZonePeripheral Zone

Page 15: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Central ZoneCentral Zone

Page 16: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Central ZoneCentral Zone

Page 17: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Central ZoneCentral Zone

Page 18: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Central ZoneCentral Zone

Page 19: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Central ZoneCentral Zone

Page 20: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

40X40X Seminal VesiclesSeminal Vesicles

Page 21: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

20X Seminal VesiclesSeminal Vesicles

Page 22: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

20X20X Seminal VesiclesSeminal Vesicles

Page 23: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

ParaganglionParaganglion

Page 24: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

NeuronsNeurons40X40X

Page 25: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Benign Benign Lesions Lesions

Page 26: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

InflammationInflammation

Page 27: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Acute InflammationAcute Inflammation

Page 28: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Acute InflammationAcute Inflammation

Page 29: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Acute InflammationAcute Inflammation

Page 30: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Acute InflammationAcute Inflammation

Page 31: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

GranulomaGranuloma

Page 32: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

20X20X Corpora AmylaceaCorpora Amylacea

Page 33: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

20X20X Corpora AmylaceaCorpora AmylaceaCalcifiedCalcified

Page 34: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

200X200X CristalloidCristalloid

Page 35: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

200X200X Stromal NodulesStromal Nodules

Page 36: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

H Y P E R P L A S I AH Y P E R P L A S I A

Page 37: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

PRIMARY NODULAR PRIMARY NODULAR HYPERPLASIAHYPERPLASIA

Page 38: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Cell Type

Mesenchymal

Fibroblast

Smooth Muscle

Basal Cells

Secretory Cells

Special PatternsUsual Patterns

Predominantlystromal

Predominantlyglandular

Mixed

Small CellHyperplasia

LeiomatousHyperplasia

Basal CellHyperplasia

CrybiformHyperplasia

BENIGN NODULAR HYPERPLASIA

Page 39: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

BENIGN NODULAR HYPERPLASIABENIGN NODULAR HYPERPLASIA

Page 40: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

BENIGN NODULAR HYPERPLASIABENIGN NODULAR HYPERPLASIA

Page 41: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

BPH & InflammationBPH & Inflammation

Page 42: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

BPH & InflammationBPH & Inflammation

Page 43: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA

Page 44: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA200X

Page 45: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

200X BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA

Page 46: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

BASAL CELL HYPERPLASIA - HMWCKBASAL CELL HYPERPLASIA - HMWCK

Page 47: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

ATROPHYATROPHY

Page 48: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

20X20X SIMPLE SIMPLE ATROPHYATROPHY

Page 49: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

200X

ATROPHYATROPHY

Page 50: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

40X ATROPHYATROPHY

Page 51: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

10X10X CYSTIC ATROPHYCYSTIC ATROPHY

Page 52: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

PINPIN

Prostatic Intraepithelial NeoplasiaProstatic Intraepithelial Neoplasia

Page 53: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Secretorycells

Lumen

Basal Cells

BasalMembrane

Normal

Dysplasia Carcinoma

Mild Moderate Severe In situ Microinvasive

Low Grade High Grade

Prostatic Intra-epithelial Neoplasia

Prostatic Intraepithelial NeoplasiaProstatic Intraepithelial Neoplasia

Page 54: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia

Page 55: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia

Page 56: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia

Page 57: Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

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